#Healthyfood #Carrots Protect Prostate Cells' Viability Against the Risk of #ProstateCancer, Researchers Find

By Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk, progression, and treatment of prostate cancer, some scientists suggested.

Prostate cancer is a condition characterized by cell growth disorderly and uncontrollably in prostate tissue. At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

Carrot, a root vegetable with orange color is a sub-spice of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

The study to verify the effect of carrots on the risk of prostate cancer by reviewing the publication of literature in August 2013 of PubMed, EMBASE, Scopus, Web of Science, the Cochrane Register, and the Chinese National Knowledge Infrastructure databases, and the references of the retrieved articles, researchers at the Zhejiang University found that intake of carrot demonstrated a significantly reduced risk of prostate cancer with the odds ratio of .82 in compared to now serving group.

The risk of prostate cancer was decreased by 5% and 6% in intake of a weekly portion of 10 g of carrot increment without precipitating adverse effects.

Dr. Xu X, the lead author suggested that the intake of carrots frequently with limited volume may have a profound effect on reduced prostate cancer risk.

Further analysis of the potential effect of lycopene extract found abundantly in tomato and carrot in decreased risk of onset and treatment of prostate cancer indicated that lycopene inhibited prostate cancer proliferation through modulated the expression of PI3K/Akt pathway prostate cancer cell lines in regulating cancerous cellular functions including metabolism, growth, proliferation.

Dysfunction of the PI3K/Akt pathway was associated with a number of human diseases including cancer, diabetes, cardiovascular disease, and neurological diseases.

Moreover, the application of lycopene also displayed a strong effect in inhibiting the proliferation of androgen-dependent prostateLNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor-gamma (PPARγ) with the function to act as a tumor suppressor in prostate cells due to its activity in the induction of agonist ligands in inhibited growth of prostate cancer cells.

Additionally, the phytochemical also expressed a significant activity in exhibiting the liver X receptor alpha (LXRα) in reducing proliferation of human oral cancer cells by promoting cell cycle arrest through increased expression of the cyclin-dependent kinase inhibitor p27, a tumor suppressor and promoted function of extracellular ATP-binding cassette transporter 1 (ABCA1) pathway in inhibited tumor growth through modulation of macrophage function within the tumor, and in established a link between cholesterol homeostasis and cancer.

Application of lycopene (10 μM) in the presence of a specific antagonist of PPARγ (GW9662) or LXRα (GGPP) exerted a huge effect in reduced liver X receptor α knockdown in the induction of resistance against LXRα in promoted the proliferation of DU145 cells.

Interestingly, lycopene in combination with the LXRα agonist T0901317, a potent chemical compound used in assays, exhibited anti-prostate cell proliferative activity through interaction with protein expression of PPARγ, LXRα, and ABCA1 in initiated cancer cell apoptosis.

In conclusion, Dr. Yang CM, the lead author said, "These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARγ-LXRα-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects".

The result findings strongly suggested that long-term intake of carrots in moderate amounts may have substantial implications in the prevention and treatment of prostate cancer. But Intake of carrot supplements should be taken with care to prevent acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Dietary carrot consumption and the risk of prostate cancer by Xu X1, Cheng Y, Li S, Zhu Y, Xu X, Zheng X, Mao Q, Xie L(PubMed)
(2) The effect of lycopene on the PI3K/Akt signaling pathway in prostate cancer by Chen J, O'Donoghue A, Deng YF, Zhang B, Kent F, O'Hare T(PubMed)
(3) Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway by Yang CM1, Lu YL, Chen HY, Hu ML(PubMed)

#Herbal #Coltsfoot Exhibits Anti-Inflammation Activties by Modulating Inflammatory Conditions, According to Scientists

By Kyle J. Norton

Inflammation is a natural response in which the white blood cells in the first line of defense of the immune system try to destroy the harmful pathogens before they can enter the body to multiply inducing the acute phase of infection.

However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading to abnormal production of collagen ratio in the initiation of scars forming.

Inflammation can be classified into 2 types
*Acute inflammation caused by trauma, microbial invasion, or noxious compounds, is a condition that starts rapidly, and becomes severe in a short time and lasts for a few days.

Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissue damage.

* Chronic inflammation is a slow, long-term inflammation, lasting for months to years caused by the inability of immunity to repair and overcome the damage or injury.

If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.

Long-term low-grade inflammation ultimately leads to tissue and organ damage, inducing a number of chronic illnesses, including diabetes and cardiovascular disease.

Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue, and insomnia as in cancer, depression, anxiety, mood disorders, and gastrointestinal complications such as constipation, diarrhea, acid reflux, unintended weight loss or gain depending on the infected tissues and organs.

According to statistics, chronic inflammatory diseases affect approximately 350 million people worldwide and nearly 43 million people in the United States, or almost 20% of the population. The prevalence of the diseases is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and healthcare sector.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native in demagogical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of hypercholesterolemia, researchers examined the anti-inflammatory effect of Tussilagone (TSL), isolated from the flower buds of Tussilago farfara (Compositae).

According to the tested analysis, RAW264.7 cells treated by TSL showed a significant activity to increase HO-1 protein expression associated with anti-inflammatory activity in a dose- and time-dependent manner without the induction of HO-1 mRNA expression.

In other words, TSL-mediated HO induction may be regulated at the translational level involved in the cellular response to stressors, growth cues, and differentiation through its anti-inflammatory properties.

Pro-inflammatory proteins such as nitric oxide (NO), tumor necrosis factor (TNF)-alpha, and prostaglandin E2 (PGE2) were also inhibited by the administration of TSL in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.

Based on the findings, researchers said, "TSL may be an effective HO-1 inducer that has anti-inflammatory effects and a valuable compound for modulating inflammatory conditions.".

Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with inflammatory disease, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages by Hwangbo C1, Lee HS, Park J, Choe J, Lee JH. (PubMed)
(2) Chronic Inflammation by Roma Pahwa, and Ishwarlal Jialal. (NCBI)

#Healthyfood #Ginger-Derived Exosome-Like Nanovesicles (GDENs) and #6Shogaol Process Anti Cancer Properties, Scientists Suggest

By Kyle J. Norton

Scientists may have found a pungent kitchen spice that processes the potency for the prevention and treatment of cancers, some studies found.
Cancer is the class of chronic illness characterized by cell growth disorderly and uncontrollably on some tissue and organs in the body.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.

Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.

At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.

The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, and family history of cancer are some most common prevalent risk factors of cancer.

Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.

According to the statistic, approximately over 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.

Lung, colorectal, breast, and prostate cancer are account for about half of all cancer diagnoses and deaths.

About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.

In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine obesity and cancer risk.

At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".

And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".

These results clearly suggested the risk of cancer is elevated in the obese and overweight population compared to healthy-weight individuals.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural whole food for the treatment of cancer with no side effects, researchers looked into ginger's antiemetic and anticancer activities.

By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol was found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-shogaol can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".

Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibiting anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from the ginger.

The application of ligands from ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.

These results suggested that ligands on ginger-derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.

Taken together, ginger-processed ligands on ginger-derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

#Herbal #AlfalfaExtracts Process Antimicrobial Activities, According to Studies

By Kyle J. Norton

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc. North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.

Alfalfa may be a potential antimicrobial agent used to treat infection or infectious-related diseases.

According to the Via Orabona 4, Università, chemical compound saponins found in the alfalfa family exhibited antimicrobial activities in a selection of medically essential yeasts, Gram-positive and negative bacteria.

Dr. Avato P, the lead author said, "(The antimicrobial) Activity (of alfalfa)was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus, and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae".

Furthermore, in the study of 40 steers fed either a sainfoin (hay or silage) or alfalfa (hay or silage) diet over a 9-week period, in vitro, the alfalfa fed group showed a decline in fecal E. coli numbers marginally.

The study also suggested the result of the decline of anti-E. coli number is due to the presence of phytochemical phenolics in alfalfa.

In fact, Karunya University in the investigation of Antimicrobial of Alfalfa(Medicago sativa) in various bacterial strains showed a positive effect of alfalfa seed extract in inhibition of
five bacterial strains namely Bacillus licheniformis, Pseudomonas aeruginosa, Lactococcus lactis, Klebsiella pneumonia. The efficacy also depends on the concentration of the extracts with the maximum inhibition seen in 300µg/ml.

There is no doubt that the intake of alfalfa regularly may be beneficiary in reducing the risk and treatment of microbial infection and diseases. But further human trials are necessary.


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Sources
(1) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship by Avato P1, Bucci R, Tava A, Vitali C, Rosato A, Bialy Z, Jurzysta M.(PubMed)
(2) Potential to reduce Escherichia coli shedding in cattle feces by using sainfoin (Onobrychis viciifolia) forage, tested in vitro and in vivo by Berard NC1, Holley RA, McAllister TA, Ominski KH, Wittenberg KM, Bouchard KS, Bouchard JJ, Krause DO.(PubMed)
(3) Antimicrobial screening of Alfalfa(Medicago sativa) in various bacterial strains by G.SHEELA JOY1 , and Dr.PHILOMENA GEORGE2 *. *Professor, 1B.Tech. student Department Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India 641114(IJPDA)

#Herbal #Andrographis in the Prevention of the Risk of #GastricUlcers, Researchers Suggest

By Kyle J. Noton

Scientists may have found a natural plant for the prevention and treatment of gastric ulcers with no side effects, according to studies.
Gastric ulcer is a condition of localized tissue erosion in the lining of the stomach.

Most cases of gastric ulcer are associated with the infection with the bacterium Helicobacter pylori (H. pylori) and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).

If you are experiencing the persistent symptoms of dull pain in the stomach, nausea or vomiting bloating, acid reflux heartburn, a burning sensation in the chest pain that may improve when you eat, drink and black color of stool due to bleeding, you may have a gastric ulcer. Please check with your doctor to rule out the possibility.

In serious cases, patients may also develop anemia and vomit blood.

According to the statistic, Peptic ulcer disease (PUD) is a very common disorder in the US, affecting over 4 million people each year.

In the study compared the bacterial infection in patients with duodenal ulcers and gastric ulcers, researchers showed the prevalence of H. pylori in antral mucosa was higher in patients with duodenal ulcers (81.5%) than in patients with gastric ulcer and non-ulcer dyspepsia (56% and 52.8%) (P<0.05) and the detection of gastric ulcer is lower compared to duodenal ulcers.

Furthermore, Among patients with antibody to H. pylori, H. pylori were detected in 85.7% of patients with duodenal ulcers, 62.5% of patients with gastric ulcers, and 22.2% of patients with non-ulcer dyspepsia(p<0.05).

These results clearly suggested that bacterial H. pylori are the main culprit to ulcers in the digestive system, an indication of adaptive immune defenses against infection and inflammation.

Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herbal plant has been used in traditional Siddha and Ayurvedic for the treatment of the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chickenpox, etc.

In order to find an effective natural compound for treating gastric cancer with no side effects, researchers evaluated the gastroprotective property of andrographolide, a chief component of the leaves of Andrographis paniculata in terms of the ulcer preventive effect in rats.

The dose-responsive study was conducted in rats pretreated with andrographolide (1, 3, and 5 mg/kg) for a period of 30 days, prior to ulcer induction by administering ethanol, aspirin, or pyloric ligation.

During the experiment, researchers found the LD(50) value was found to be 48 mg/kg b. wt and the effective dose was found to be 3 mg/kg.

The application of andrographolide showed an increasing level of pH and a decrease in titrable acidity observed in the gastric fluid of rats pretreated with the test drug.

Andrographolide reduced the expression of the gastric tissue H(+)-K(+) ATPase, an enzyme that functions to acidify the stomach. and myeloperoxidase activities that were elevated in ulcer-induced animals.

Furthermore, the antioxidants and mucin levels were significantly maintained in the gastric tissue of drug-pretreated animals. No toxicity was found in the tested rats.


After taking into account co and confounders, researchers wrote in the final report, "the ulcer preventive efficacy of andrographolide may probably due to its antioxidant, cytoprotective, and antiacid secretory effects"

Additionally, in a study pretreated with HAEAP (100,200,500mg/kg b. wt for 30 days) and then gastric ulcers were induced by ethanol, aspirin, pylorus ligation, and cold restraint stress models firmly supported the use of a hydroalcoholic extract of Andrographispaniculata (HAEAP) for treatment of gastric ulcers.

Also, the ulcer score was found to be low in HAEAP-pretreated rats, particularly at the dose of 200 mg/kg b.wt. and the tested drug significantly reduced the acidity, pepsin concentration, myeloperoxidase, and H(+)K(+)ATPase activities in ethanol-administered rats as of that in the previous study.

More importantly, the tested drug also normalized the elevated TBARS, formed as a byproduct of lipid peroxidation, overexpression of free radicals, and decreased glutathione (GSH), the antioxidant enzymes produced by the host and mucin levels.

Taken altogether, herbal Andrographis may be considered a functional remedy for the prevention and treatment of gastric ulcers, pending the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. by Saranya P, Geetha A, Selvamathy SM.(PubMed)
(2) A biochemical study on the gastroprotective effect of hydroalcoholic extract of Andrographis paniculata in rats. by Panneerselvam S, Arumugam G.(PubMed)
(3) Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats. by Wasman SQ, Mahmood AA, Chua LS, Alshawsh MA, Hamdan S.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)

#Healthyfood #Cucumber in the Management of Moderate Knee #Osteoarthritis, Clinical Trials Suggest

By Kyle J. Norton

Osteoarthritis (OA) is a chronic condition affecting the joints in the hands, knees, hips, and spine mostly occurring in older adults.
More precisely, OA is a result in which the protective cartilage on the ends of your bones wears down over time due to repetitive movement of the same joints that cause the thinning cartilage, leading to bone rubbing on bone.

According to the statistics, in the US, over 25 million people are living with OA.

The precisive characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest(8).

Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).

Believe it or not, other causes of OA also include
1. Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints(34) and is often associated with the senescence of invertebrates. arising from long term wear and tear, heavy long-term use or specific injuries(35).

The improper repair process of injuring of joints can also result in symptoms of Osteoarthritis (OA)(36) in old age(37), according to TCM.

2. Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA)(35)(38), such as vitamin D.


On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA)(38).

3. Cartilage
Cartilage is a flexible connective tissue cushioned the ends of bones in your joints and allowed the joints to move smoothly. Rough or wears down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone(39)(40).

In other words, osteoarthritis (OA) may also be the result of injury (35), overuse(15)(16), Rheumatoid Arthritis(41), etc.

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a potential compound for the treatment of osteoarthritis, researchers evaluated the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber; CSE) against glucosamine-chondroitin (GC) in the management of moderate knee OA.

The randomized double-blind, parallel-group clinical trial took place in three different centers. included 122 patients (56 males and 66 females) aged between 40 and 75 years and diagnosed with moderate knee OA assigned to 2 groups (n= 61).

Among the groups, the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally 10 mg twice daily of CSE.

According to the assays, on days 30, 60, 90, 120, 150, and 180 compared to the baseline (Day 0), the WOMAC score in the CSE group was decreased by 22.44% and 70.29% on days 30 and 180, respectively, compared to a 14.80% and 32.81% respectively decrease in the GC group.

The pain scores also showed similar trends in flavor to the CSE group. There was no adverse effect on the course of the experiment.

In other words, CSE is more effective for the treatment of OA compared to that of GC.

Dr. the lead scientists wrote, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".

Taken altogether, cucumber extract may be used for the treatment of OA, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton

#Healthyfood #Eggplants In the Inhibition of the #Acute and #ChronicInflammatoryDiseases, According to Studies

By Kyle J. Norton

Eggplant may be used as a therapeutic and positive anti-inflammatory functional food without alternating the immune activity in the acute phase of infection, some scientists opinionated.
Eggplant with deep purple color is a species of S. Melongena, belongs to the family Solanaceae cultivated in southern and eastern Asia since prehistory, and is native to India.

Inflammation is a natural expression by the immune system in the induction of white blood cells to protect our body against infection caused by foreign invasion.

In the differentiation of water extract of Solanum melongena L. (Solanaceae) effect in the induction of antioxidant, analgesic, hypolipidemic, and antiallergic activity in mice induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hind paw scientists found that oral administration of the extract at doses of 5, 10, and 100 mg/kg displayed a strong effect in inhibition of both paw edema and vascular permeability.

Further analysis also showed that the highest dose injection of 10 mg/kg expressed the greatest activity compared to the others in significantly inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity in stimulated immune function activated pro-inflammatory cytokines and tumor necrosis factor (TNF)-alpha expression to precipitate inflammation in response to the acute phase of infection.

After taking into account other confounders, Dr. Umamageswari MS suggested that water extract of the S. Melongena (SMWE) inhibits PAR2 agonist-induced mouse paw edema, through its anti-inflammatory expression.


According to the investigated the inflammatory activities of aqueous extract of leaves of Solanum melongena Linn in carrageenan-induced paw edema, in comparison to standard medicine aspirin, oral application of Solanum melongena L. in different doses of 100mg/kg, 200mg/kg, 400mg/kg at 1(st) h, 3(rd) h, and 5(th) after injection revealed a significant effect in reduced inflammation linearly induced by carrageenan toxicity in a dose-dependent manner.

Additional differentiation, also suggested that the doses of 200mg/kg and 400 mg/kg of aqueous extract of S. Melongena L showed a percentage of inhibition of 42.62% which is less than the standard drug aspirin which showed 64.5% inhibition.

In the free radical perspective, the investigation of 4 our new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10) isolated from the roots of Solanum melongena L. also demonstrated significant activity in inhibitions of inflammatory From effect From caused by free radical species nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages through their antioxidant effect.

Interestingly, the study also found that not all compounds extracted from the roots expressed the same levels of antioxidant properties in reduced inflammation induced by ROS. In comparison to other compounds, compound 1 exerted an antioxidant effect without inhibiting free radical nitric oxide production.

The findings suggested that eggplant may be used as a functional food in reducing the risk of inflammation in acute infection and as an adjunct therapy in combination with the standard treatment of chronic inflammatory diseases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) The aqueous extract of Solanum melongena inhibits PAR2 agonist-induced inflammation by Han SW1, Tae J, Kim JA, Kim DK, Seo GS, Yun KJ, Choi SC, Kim TH, Nah YH, Lee YM.(PubMed)
(2) Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals by Umamageswari MS1, Maniyar YA2.(PubMed)
(3) Anti-inflammatory lignanamides from the roots of Solanum melongena L by Sun J1, Gu YF1, Su XQ1, Li MM1, Huo HX1, Zhang J1, Zeng KW2, Zhang Q3, Zhao YF3, Li J4, Tu PF5.(PubMed)