By Kyle J. Norton
Scientists may have found a natural contraceptive for the prevention of conception, according to studies.
Anti-fertility is an act with the intention to prevent, reduce or destroy fertility by using substances such as contraceptives, and herbal medicine in under-developing the world.
Contraceptives are a conventional medicine that allows you to enjoy sex without the risk of getting pregnant. The contraceptive pill is the most common contraceptive agent used in the Western world.
Many women also use a contraceptive pill for the treatment of irregular menstruation, painful or heavy periods, endometriosis, acne, and premenstrual syndrome (PMS).
The most common side effects of the contraceptive pill include gastrointestinal discomfort, intermenstrual spotting, breast tenderness, headaches, migraine, mood changes, missed periods, and vaginal discharge.
Some women using the pill also experience symptoms of decreased libido.
Dr. Davis AR, the lead scientist in the examination of the effect of OCs on sexual functioning, wrote, "In 30 original research studies. In the retrospective, uncontrolled studies (n = 17), it was found that most women reported an increase in libido during OC use. In the uncontrolled, prospective studies (n = 4), it was found that most women reported little change in libido during OC use. In the perspective and cross-sectional controlled studies (n = 4), women using OCs reported both increased and decreased libido compared to non-OC users". and " In the most recent and well-conducted trial, a decrease in libido in OC users compared to placebo users was found".
These results strongly suggested that women may react differently to the use of the contraceptive pill, probably due to the based hormones in the body.
Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herbal plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
With an aim to find a natural ingredient with less cost and no side effects for male contraception, researchers at the Jamal Mohamed College examined the anti-fertility of dry leaf powder of A. paniculata in an animal model.
Dry leaf powder of A. paniculata fed orally to male albino rats, at a dose level of 20 mg powder per day for 60 days showed a significant effect on cessation of spermatogenesis, degenerative changes in the seminiferous tubules, regression of Leydig cells.
The antifertility activity also can be observed by the regressive and/or degenerative changes in the epididymis, seminal vesicle, ventral prostate, and coagulating gland.
Furthermore, injection of the powder also reduced the weight and fluid content of the accessory glands.
The results of the treatment also demonstrated the accumulation of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in the testis and alkaline phosphatase in the testis and ventral prostate.
The finding clearly suggested that dry leaf powder of A. paniculata processes an antispermatogenic and/or antiandrogenic effect on the mice.
Moreover, in albino Wistar rats, researchers tested the anti-male fertility of andrographolide, a major bioactive compound found in herbal Andrographis extract.
The testosterone levels and fertility indices in treatment groups were found to be comparable with that of the control indicating no effect on fertility.
Total sperm count and sperm motility were not affected. The testes and epididymides did not show any gross or histopathological changes.
Administering 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating.
The treated groups showed no signs of dose-dependent toxicity. The body weight gain and feed consumption were not affected at any of the dose levels.
The finding clearly suggested that the efficacy of herbal Andrographis in the induction of male infertility is not attributed to a single ingredient but all ingredients in the herbal medicine.
Taken altogether, herbal Andrographis may be considered a natural anti-male fertility or male contraceptive agent with no side effect, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in the male albino rat by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographispaniculata in male Wistar rats, by Allan JJ, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)
(4) Oral contraceptives and libido in women by Davis AR1, Castaño PM. (PubMed)
Tuesday, 6 June 2023
#Healthyfood #CucumberLeaf Extract Inhibits the Neuroprotective Effects by Preventing Neuron Oxidative Damaage , Scientists Say
By Kyle J. Norton
The central nervous system containing the brain and the spinal cord is the complex system of nerve tissues that controls the activities of the human body.
It is the center that controls our thoughts, the interpreter of our external environment, and the body's movement.
Neuroprotection is an action, including the use of substances such as herbal medicines to protect our brain against the loss and death of neurons.
Believe it or not, diseases associated with CNS are including
* Brain and spinal cord trauma, a type of condition can lead paralysis to or mood disorders, depending on the location of the injury.
*CNS Infections caused by micro-organisms and viruses can lead as is meningitis and malaria.
*Diseases associated with neuro-degeneration, include Alzheimer's disease and Parkinson's disease.
* Diseases associated with birth defects include anencephaly.
* Brain tumors are caused by abnormal cell growth in the brain or metastases by primary cancer from other tissues and organs.* Autoimmune disorders are caused by the immune system that attacks mistakenly the brain and spinal cord cells.
* Stroke caused the death of neurons due to the reduced blood supply to the brain.
However, out of many risk factors involved in the onset of neurodegenerative disease, some researchers suggested that the promotion of a high-fat diet may be the major culprit that causes the rise of the incidence in the Western world.
Dr. the lead scientist wrote, "This increase in glial responses was associated with increased plaque burden in the hippocampus. Interestingly, given recent studies highlighting the importance of TREM2 in microglia/monocytes in AD susceptibility and progression, B6 and APP/PS1 mice fed the western diet showed significant increases in TREM2+ microglia/monocytes".
And, " Therefore, an increase in TREM2+ microglia/monocytes may underlie the increased risk from a western diet to age-related neurodegenerative diseases such as Alzheimer’s disease".
On finding a potential ingredient that processes neuroprotective effect researchers evaluated the protective effect of Cucumis melo var. flexuosus (C. Melo var. flexuosus) leaf extract on the brains of diabetic rats.
The study included dietetic male albino rats induced by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg bw) and .divided into 5 groups of 6 rats each, a normal control group and four diabetic groups.
Additionally, 3/4 other groups were treated with C. Melo var. flexuosus (cucumber) leaf extract at the doses of 30, 60, and 120 mg/kg bw for a period of 30 days compared to the nontreatment of a diabetic group.
Compared to non-treated diabetic rats, treated rats protected the brain neurons by markedly increasing the plasma dopamine, melatonin, and brain vascular endothelial growth factor-A levels, particularly the antioxidant activity in the brain tissues.
In other words, cucumber leaf extract processes a neuroprotective effect by preventing neuron oxidative damage associated with diabetes.
Based on the results, Dr. Ibrahim DS, at Benha University wrote, "It can be concluded that the C. Melo var. flexuosus leaf extract exerts a neuroprotective effect against oxidative damage associated with diabetes".
In order to reveal more information about cucumber neuroprotective property, researchers examined the effect of Cucurbitacins (CuB), a major bioactive compound from cucumber on neuroinflammatory responses that are involved in neuronal injury.
According to the tested results, pretreatment with Cucurbitacins significantly reduced the production of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6 iNOS and COX-2 expression) in microglia, a type of neuroglia (glial cell) located throughout the brain and spinal cord.
Furthermore, CuB also inhibited the proteins and pathways associated with the stimulation of immune response in the activated production of inflammation.
Moreover, the neuroprotective of CuB was also attributed to the bioactive compound in the activation of (Nrf2/ARE pathway) pathways involved in significantly greater resistance to oxidative stress and protein associated with the production of antioxidants and anti-inflammatory cytokines.
Dr. Park SY, the lead scientist said, "Cucurbitacins is a potent activator of the Nrf2/ARE pathway and is therapeutically relevant not only to neuroinflammatory responses of microglia but also neuroinflammation mediated neuronal injury".
Taken altogether, cucumber processed with high levels of CuB may be considered a neuroprotective remedy, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Neuroprotective effect of Cucumis melo Var. flexuous leaf extract on the brains of rats with streptozotocin-induced diabetes by Ibrahim DS. (PubMed)
(2) Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition by Park SY1, Kim YH1, Park G2. (PubMed)
(3) Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease by Leah C. Graham,1,2 Jeffrey M. Harder,1 Ileana Soto,1 Wilhelmine N. de Vries,1,3Simon W. M. John,1,2,3,4 and Gareth R. Howella. (PMC)
The central nervous system containing the brain and the spinal cord is the complex system of nerve tissues that controls the activities of the human body.
It is the center that controls our thoughts, the interpreter of our external environment, and the body's movement.
Neuroprotection is an action, including the use of substances such as herbal medicines to protect our brain against the loss and death of neurons.
Believe it or not, diseases associated with CNS are including
* Brain and spinal cord trauma, a type of condition can lead paralysis to or mood disorders, depending on the location of the injury.
*CNS Infections caused by micro-organisms and viruses can lead as is meningitis and malaria.
*Diseases associated with neuro-degeneration, include Alzheimer's disease and Parkinson's disease.
* Diseases associated with birth defects include anencephaly.
* Brain tumors are caused by abnormal cell growth in the brain or metastases by primary cancer from other tissues and organs.* Autoimmune disorders are caused by the immune system that attacks mistakenly the brain and spinal cord cells.
* Stroke caused the death of neurons due to the reduced blood supply to the brain.
However, out of many risk factors involved in the onset of neurodegenerative disease, some researchers suggested that the promotion of a high-fat diet may be the major culprit that causes the rise of the incidence in the Western world.
Dr. the lead scientist wrote, "This increase in glial responses was associated with increased plaque burden in the hippocampus. Interestingly, given recent studies highlighting the importance of TREM2 in microglia/monocytes in AD susceptibility and progression, B6 and APP/PS1 mice fed the western diet showed significant increases in TREM2+ microglia/monocytes".
And, " Therefore, an increase in TREM2+ microglia/monocytes may underlie the increased risk from a western diet to age-related neurodegenerative diseases such as Alzheimer’s disease".
On finding a potential ingredient that processes neuroprotective effect researchers evaluated the protective effect of Cucumis melo var. flexuosus (C. Melo var. flexuosus) leaf extract on the brains of diabetic rats.
The study included dietetic male albino rats induced by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg bw) and .divided into 5 groups of 6 rats each, a normal control group and four diabetic groups.
Additionally, 3/4 other groups were treated with C. Melo var. flexuosus (cucumber) leaf extract at the doses of 30, 60, and 120 mg/kg bw for a period of 30 days compared to the nontreatment of a diabetic group.
Compared to non-treated diabetic rats, treated rats protected the brain neurons by markedly increasing the plasma dopamine, melatonin, and brain vascular endothelial growth factor-A levels, particularly the antioxidant activity in the brain tissues.
In other words, cucumber leaf extract processes a neuroprotective effect by preventing neuron oxidative damage associated with diabetes.
Based on the results, Dr. Ibrahim DS, at Benha University wrote, "It can be concluded that the C. Melo var. flexuosus leaf extract exerts a neuroprotective effect against oxidative damage associated with diabetes".
In order to reveal more information about cucumber neuroprotective property, researchers examined the effect of Cucurbitacins (CuB), a major bioactive compound from cucumber on neuroinflammatory responses that are involved in neuronal injury.
According to the tested results, pretreatment with Cucurbitacins significantly reduced the production of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6 iNOS and COX-2 expression) in microglia, a type of neuroglia (glial cell) located throughout the brain and spinal cord.
Furthermore, CuB also inhibited the proteins and pathways associated with the stimulation of immune response in the activated production of inflammation.
Moreover, the neuroprotective of CuB was also attributed to the bioactive compound in the activation of (Nrf2/ARE pathway) pathways involved in significantly greater resistance to oxidative stress and protein associated with the production of antioxidants and anti-inflammatory cytokines.
Dr. Park SY, the lead scientist said, "Cucurbitacins is a potent activator of the Nrf2/ARE pathway and is therapeutically relevant not only to neuroinflammatory responses of microglia but also neuroinflammation mediated neuronal injury".
Taken altogether, cucumber processed with high levels of CuB may be considered a neuroprotective remedy, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Neuroprotective effect of Cucumis melo Var. flexuous leaf extract on the brains of rats with streptozotocin-induced diabetes by Ibrahim DS. (PubMed)
(2) Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition by Park SY1, Kim YH1, Park G2. (PubMed)
(3) Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease by Leah C. Graham,1,2 Jeffrey M. Harder,1 Ileana Soto,1 Wilhelmine N. de Vries,1,3Simon W. M. John,1,2,3,4 and Gareth R. Howella. (PMC)
The Effects of #Herbal #Chamomile on #Dermatitis, According to Studies
By Kyle J. Norton
Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Dermatitis or eczema is defined as a condition of inflammation of the skin including itchy, erythematous, vesicular, weeping, and crusting patches.
The use of chamomile oil in folk medicine for the treatment of skin disorders may have been found to be effective in modern medicine, according to Howon University, the application of German chamomile oil to alleviating atopic dermatitis, such as reduced serum IgG1 level and significantly lower serum histamine level through influencing of Th2 cell activation(1).
Dr. Dohil MA. in the study of herbal effects on atopic dermatitis and another inflammatory skin disease indicated that there may be a positive effect of herbal medicine, including chamomile through the present recent multicenter and international clinical studies that support their efficacy and safety profile for a variety of inflammatory skin conditions(2). and herbs containing anti-inflammatory activity such as chamomile may be particularly well suited as alternatives to pharmacologic therapies in chronic conditions for which long-term use is required,(3), Dr. Wu J. said.
Although German chamomile may be effective for the treatment of skin disorders, it was found to have an allergic effect in some patients, in external use of chamomile tea or the use of chamomile-containing topical herbal remedies, due to its chemical constituent herniarin(4).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
References
(1) Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.by Lee SH1, Heo Y, Kim YC.(PubMed)
(2) Natural ingredients in atopic dermatitis and other inflammatory skin disease.
Dohil MA.(PubMed)
(3) Anti-inflammatory ingredients by Wu J.(PubMed)
(4) The coumarin herniarin as a sensitizer in German chamomile[Chamomilla recutita (L.) Rauschert, Compositae] by Paulsen E1, Otkjaer A, Andersen KE.(PubMed)
Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Dermatitis or eczema is defined as a condition of inflammation of the skin including itchy, erythematous, vesicular, weeping, and crusting patches.
The use of chamomile oil in folk medicine for the treatment of skin disorders may have been found to be effective in modern medicine, according to Howon University, the application of German chamomile oil to alleviating atopic dermatitis, such as reduced serum IgG1 level and significantly lower serum histamine level through influencing of Th2 cell activation(1).
Dr. Dohil MA. in the study of herbal effects on atopic dermatitis and another inflammatory skin disease indicated that there may be a positive effect of herbal medicine, including chamomile through the present recent multicenter and international clinical studies that support their efficacy and safety profile for a variety of inflammatory skin conditions(2). and herbs containing anti-inflammatory activity such as chamomile may be particularly well suited as alternatives to pharmacologic therapies in chronic conditions for which long-term use is required,(3), Dr. Wu J. said.
Although German chamomile may be effective for the treatment of skin disorders, it was found to have an allergic effect in some patients, in external use of chamomile tea or the use of chamomile-containing topical herbal remedies, due to its chemical constituent herniarin(4).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
References
(1) Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.by Lee SH1, Heo Y, Kim YC.(PubMed)
(2) Natural ingredients in atopic dermatitis and other inflammatory skin disease.
Dohil MA.(PubMed)
(3) Anti-inflammatory ingredients by Wu J.(PubMed)
(4) The coumarin herniarin as a sensitizer in German chamomile[Chamomilla recutita (L.) Rauschert, Compositae] by Paulsen E1, Otkjaer A, Andersen KE.(PubMed)
#Phytochemical #Isothiocyanates In the Prevention of #CardiovascularDisease #CVD and Strokes, Scientists Say
By Kyle J. Norton
Bioactive dithiolthiones found in cruciferous vegetables may be the next-generation ingredient for the prevention and treatment of cardiovascular disease, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Cardiovascular disease is a class of conditions associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of the heart and blood vessels.
According to the CVD statistics, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
There are many causes of cardiovascular disease. Most CVD is caused by high blood pressure which contributes to the hardening of the arteries.
Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot, a major cause of CVD.
Other risk factors associated with the onset of cardiovascular disease include an unhealthy diet, lack of exercise, being overweight, and smoking.
Dr. Haskell W, Stanford University, School of Medicine in the examine the lifestyle change in the risk of CVD indicated that there is a strong relationship between the way a person or population lives and their risk for developing or dying from cardiovascular disease (CVD).
He wrote, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program"/
For people with higher-risk CVD, the doctor continued, "medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia".
With an aim to find a natural ingredient or whole food with a cardioprotective effect, researchers examined whether sulforaphane protects the heart against I/R injury.
Sprague-Dawley rats selected to the study were given sulforaphane (500microg/kg/day) or vehicle intraperitoneally for 3 days and global ischemia was performed using isolated perfused Langendorff hearts.
Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts.
Sulforaphane markedly decreased the infarcted size and attenuated the increased lactate dehydrogenase level in the effluent during reperfusion, similar to that of 5-hydroxy decanoic acid (5-HD).
Application of sulforaphane also attenuated the post-ischemia increased the concentration of atrial natriuretic peptide in coronary effluent and decreased levels of free radicals produced during and after injury.
Particularly, sulforaphane also protected the heart cell against damage and apoptosis by promoting heart cell cycle division.
The finding clearly indicated the cardioprotective effect of the sulforaphane against acute I/R injury.
In order to understand the therapeutic effect of sulforaphane protecting the myocardium from ischaemic reperfusion injury, researchers compared the cardio effects among cooked and fresh broccoli.
The study included two groups of rats fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given a vehicle only for the same period of time.
At the end of the study, by examing the 30 min ischemia followed by 2 h of reperfusion, researchers surprisingly found that both cooked and steamed broccoli display significantly improved post-ischemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control, but steamed broccoli showed superior cardioprotective abilities compared with the cooked broccoli.
These results were attributed to the broccoli effect in enhancing the levels of proteins associated with cell survival, increasing the levels of antioxidants, and decreasing the levels of proteins associated with cell damage and apoptosis.
More importantly, the expressions of redox proteins (the thioredoxin (Trx)) associated with the reduction of oxidative stress were enhanced only in the steamed broccoli group.
Dr. Mukherjee S, the lead scientist said, "The present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx"
Taken altogether, Isothiocyanates or sulforaphane may have a potential effect on the prevention and treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. by Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH. (PubMed)
(2) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(3) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE .(PubMed)
(4) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)
Bioactive dithiolthiones found in cruciferous vegetables may be the next-generation ingredient for the prevention and treatment of cardiovascular disease, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Cardiovascular disease is a class of conditions associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of the heart and blood vessels.
According to the CVD statistics, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
There are many causes of cardiovascular disease. Most CVD is caused by high blood pressure which contributes to the hardening of the arteries.
Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot, a major cause of CVD.
Other risk factors associated with the onset of cardiovascular disease include an unhealthy diet, lack of exercise, being overweight, and smoking.
Dr. Haskell W, Stanford University, School of Medicine in the examine the lifestyle change in the risk of CVD indicated that there is a strong relationship between the way a person or population lives and their risk for developing or dying from cardiovascular disease (CVD).
He wrote, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program"/
For people with higher-risk CVD, the doctor continued, "medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia".
With an aim to find a natural ingredient or whole food with a cardioprotective effect, researchers examined whether sulforaphane protects the heart against I/R injury.
Sprague-Dawley rats selected to the study were given sulforaphane (500microg/kg/day) or vehicle intraperitoneally for 3 days and global ischemia was performed using isolated perfused Langendorff hearts.
Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts.
Sulforaphane markedly decreased the infarcted size and attenuated the increased lactate dehydrogenase level in the effluent during reperfusion, similar to that of 5-hydroxy decanoic acid (5-HD).
Application of sulforaphane also attenuated the post-ischemia increased the concentration of atrial natriuretic peptide in coronary effluent and decreased levels of free radicals produced during and after injury.
Particularly, sulforaphane also protected the heart cell against damage and apoptosis by promoting heart cell cycle division.
The finding clearly indicated the cardioprotective effect of the sulforaphane against acute I/R injury.
In order to understand the therapeutic effect of sulforaphane protecting the myocardium from ischaemic reperfusion injury, researchers compared the cardio effects among cooked and fresh broccoli.
The study included two groups of rats fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given a vehicle only for the same period of time.
At the end of the study, by examing the 30 min ischemia followed by 2 h of reperfusion, researchers surprisingly found that both cooked and steamed broccoli display significantly improved post-ischemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control, but steamed broccoli showed superior cardioprotective abilities compared with the cooked broccoli.
These results were attributed to the broccoli effect in enhancing the levels of proteins associated with cell survival, increasing the levels of antioxidants, and decreasing the levels of proteins associated with cell damage and apoptosis.
More importantly, the expressions of redox proteins (the thioredoxin (Trx)) associated with the reduction of oxidative stress were enhanced only in the steamed broccoli group.
Dr. Mukherjee S, the lead scientist said, "The present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx"
Taken altogether, Isothiocyanates or sulforaphane may have a potential effect on the prevention and treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. by Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH. (PubMed)
(2) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(3) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE .(PubMed)
(4) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)
#Healthyfood #Garlic Inhibits the Parameters that Cause the Onset of #LungCancer, Researchers Suggest
By Kyle J. Norton
Many researchers have raised questions about the quality of the herbs because geographic differences, time of growth and harvest, etc. may affect their's potency. I do believe, these questions can only be answered by experienced herbalists.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In the Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistics.
A recent study suggested that garlic may be used as a chemoprevention and treatment of lung cancer.
According to the study by the Medical Research Center, College of Medicine allyl sulfur compounds and garlic extract found in garlic exhibited anti nonsmall cell lung cancer cell line effects through interference on tumor cell division and tumor cell proliferation.
Benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, oil-soluble organosulfur compounds in garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage, after administration.
The examination of the association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that compared with no intake, raw garlic intake is associated with a lower risk of development of lung cancer with a dose-response pattern.
In fact, the Epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.
Dr. Yang GQ, the lead researcher at the 107th Hospital of the People's Liberation Army said, "Black garlic extract (BGE) could have a significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in the G2/M stage".
Whole-food garlic in reduced the risk and treatment of lung cancer probably due to the effect of its phytochemicals. Adding a portion of garlic to your diet is beneficiary for increased protection against lung cancer development.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in nonsmall cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)
Many researchers have raised questions about the quality of the herbs because geographic differences, time of growth and harvest, etc. may affect their's potency. I do believe, these questions can only be answered by experienced herbalists.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In the Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistics.
A recent study suggested that garlic may be used as a chemoprevention and treatment of lung cancer.
According to the study by the Medical Research Center, College of Medicine allyl sulfur compounds and garlic extract found in garlic exhibited anti nonsmall cell lung cancer cell line effects through interference on tumor cell division and tumor cell proliferation.
Benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, oil-soluble organosulfur compounds in garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage, after administration.
The examination of the association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that compared with no intake, raw garlic intake is associated with a lower risk of development of lung cancer with a dose-response pattern.
In fact, the Epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.
Dr. Yang GQ, the lead researcher at the 107th Hospital of the People's Liberation Army said, "Black garlic extract (BGE) could have a significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in the G2/M stage".
Whole-food garlic in reduced the risk and treatment of lung cancer probably due to the effect of its phytochemicals. Adding a portion of garlic to your diet is beneficiary for increased protection against lung cancer development.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in nonsmall cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)
#Herbal #Catsclaw Processes Anti-Cancer Activities, Scientists Say
By Kyle J. Norton
Cat's claw found in the tropical jungles of South and Central America may have a potential effect in reducing the risk and treatment of the early onset of irregular cell growth, some scientists suggested.
Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where the cancer begins.
As of today, researchers do not know what are the exact causes of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.
Genetic mutation of BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and the alternation of gene PTEN.that suppress the growth of tumors also increases the risk of cancers.
Dr. N Parsa in the study "Environmental Factors Inducing Human Cancers" wrote, "(Environment toxins cause) genetic mutations that would eventually alter the normal pathway of cellular proliferation and differentiation. Genetic mutations in four groups of genes; (Oncogenes, Tumor suppressor genes, Apoptosis genes, and DNA repair genes) play a vital role in altering the normal cell division" and " Inhibition of carcinogenic exposures wherever possible should be the goal of cancer prevention programs to reduce exposures from all environmental carcinogens".
The statement illustrated that environmentally induced genetic alternation at the cellular levels can initiate the early onset of cancer.
According to the World Cancer Research Fund UK What you eat can have a big impact on your risk of developing cancer. eating too much fat and sugar and less of fruits and vegetables are the most prevalent risk factors of cancers.
Truly, "Cancer is a Preventable Disease that Requires Major Lifestyle Changes", Dr. Preetha Anand, the lead scientist in the medical literature said, "Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle" and "cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups".
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer, and diseases of the urinary tract, etc...
In the study of the anti-cancer effect of the preparation of Cat's claw in several cancer cell lines to determine the IC (50) values with different quantitative and qualitative oxindole alkaloid composition: B/W(37) --bark extracted in water at 37 °C, B/W(b)--bark extracted in boiling water, B/50E(37) --bark extracted in 50% ethanol at 37 °C, B/E(b)--bark extracted in boiling 96% ethanol, B/96E(37) --bark extracted in 96% ethanol at 37 °C and B/SRT--bark extracted in water and dichloromethane researchers found that
* A high correlation between the total oxindole alkaloid content (from 0.43% to 50.40% d.m.) and the antiproliferative activity of the preparations (IC(50) from >1000 μg/ml to 23.57 μg/ml).
* B/96E(37) and B/SRT were the most cytotoxic preparations
* B/96E(37) are most active against Lewis lung carcinoma (LL/2) [IC(50) =25.06 μg/ml], cervical carcinoma (KB) [IC(50) =35.69 μg/ml], and colon adenocarcinoma (SW707) [IC(50) =49.06 μg/ml].
* B/SRT was especially effective in inhibiting the proliferation of cervical carcinoma (KB) [IC(50) =23.57 μg/ml], breastcarcinoma (MCF-7) [IC(50) =29.86 μg/ml], and lung carcinoma (A-549) [IC(50) =40.03 μg/ml].
* In animal studies on mice bearing Lewis lung carcinoma showed significant inhibition of tumor growth by B/W(37) administered for 21 days at daily doses of 5 and 0.5 mg (p=0.0009).
* There are no adverse effects in all preparations.
The results suggested that Cat's claw is effective against cancer through its cytotoxicity, however, the cancer cell inhibition is totally depending on the dose of concentrations.
Furthermore, in the study to reaffirm the traditional use of the preparations from Uncaria tomentosa, a South American Rubiaceae, for the treatment of infective, inflammatory, and tumoral processes, researchers launched an investigation to test whether the pentacyclic oxindole alkaloid mitraphylline isolated from the dried inner bark of this plant species has a similar anti-cancer effect in human Ewing's sarcoma MHH-ES-1 and breast cancer MT-3 cell lines.
Administration at the IC (50) +/- SE values of17.15 +/- 0.82 microM for MHH-ES-1 and 11.80 +/- 1.03 microM for MT-3 for 30 hours exerted a clinically significant inhibition of the human sarcoma and breast cancer cell line in a dose-dependent manner.
The finding suggested that Cat's claw may have a chemotherapeutic effect in the prevention and treatment of cancer without inducing any adverse effects.
However, due to the limitation of the above studies, additional data collection large example size and multi-center studies performed with human consumption of the preparations during the course of the disease will be necessary to complete the picture of Cat's claw anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Topical plant database (Rain tree)
(2) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition by Pilarski R, Filip B, Wietrzyk J, Kuraś M, Gulewicz K.(PubMed)
(3) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines, by García Giménez D, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(4) Environmental Factors Inducing Human Cancers by N Parsa. (PMC)
(5) Cancer is a Preventable Disease that Requires Major Lifestyle Changes by Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar,Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal. (PMC)
Cat's claw found in the tropical jungles of South and Central America may have a potential effect in reducing the risk and treatment of the early onset of irregular cell growth, some scientists suggested.
Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where the cancer begins.
As of today, researchers do not know what are the exact causes of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.
Genetic mutation of BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and the alternation of gene PTEN.that suppress the growth of tumors also increases the risk of cancers.
Dr. N Parsa in the study "Environmental Factors Inducing Human Cancers" wrote, "(Environment toxins cause) genetic mutations that would eventually alter the normal pathway of cellular proliferation and differentiation. Genetic mutations in four groups of genes; (Oncogenes, Tumor suppressor genes, Apoptosis genes, and DNA repair genes) play a vital role in altering the normal cell division" and " Inhibition of carcinogenic exposures wherever possible should be the goal of cancer prevention programs to reduce exposures from all environmental carcinogens".
The statement illustrated that environmentally induced genetic alternation at the cellular levels can initiate the early onset of cancer.
According to the World Cancer Research Fund UK What you eat can have a big impact on your risk of developing cancer. eating too much fat and sugar and less of fruits and vegetables are the most prevalent risk factors of cancers.
Truly, "Cancer is a Preventable Disease that Requires Major Lifestyle Changes", Dr. Preetha Anand, the lead scientist in the medical literature said, "Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle" and "cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups".
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer, and diseases of the urinary tract, etc...
In the study of the anti-cancer effect of the preparation of Cat's claw in several cancer cell lines to determine the IC (50) values with different quantitative and qualitative oxindole alkaloid composition: B/W(37) --bark extracted in water at 37 °C, B/W(b)--bark extracted in boiling water, B/50E(37) --bark extracted in 50% ethanol at 37 °C, B/E(b)--bark extracted in boiling 96% ethanol, B/96E(37) --bark extracted in 96% ethanol at 37 °C and B/SRT--bark extracted in water and dichloromethane researchers found that
* A high correlation between the total oxindole alkaloid content (from 0.43% to 50.40% d.m.) and the antiproliferative activity of the preparations (IC(50) from >1000 μg/ml to 23.57 μg/ml).
* B/96E(37) and B/SRT were the most cytotoxic preparations
* B/96E(37) are most active against Lewis lung carcinoma (LL/2) [IC(50) =25.06 μg/ml], cervical carcinoma (KB) [IC(50) =35.69 μg/ml], and colon adenocarcinoma (SW707) [IC(50) =49.06 μg/ml].
* B/SRT was especially effective in inhibiting the proliferation of cervical carcinoma (KB) [IC(50) =23.57 μg/ml], breastcarcinoma (MCF-7) [IC(50) =29.86 μg/ml], and lung carcinoma (A-549) [IC(50) =40.03 μg/ml].
* In animal studies on mice bearing Lewis lung carcinoma showed significant inhibition of tumor growth by B/W(37) administered for 21 days at daily doses of 5 and 0.5 mg (p=0.0009).
* There are no adverse effects in all preparations.
The results suggested that Cat's claw is effective against cancer through its cytotoxicity, however, the cancer cell inhibition is totally depending on the dose of concentrations.
Furthermore, in the study to reaffirm the traditional use of the preparations from Uncaria tomentosa, a South American Rubiaceae, for the treatment of infective, inflammatory, and tumoral processes, researchers launched an investigation to test whether the pentacyclic oxindole alkaloid mitraphylline isolated from the dried inner bark of this plant species has a similar anti-cancer effect in human Ewing's sarcoma MHH-ES-1 and breast cancer MT-3 cell lines.
Administration at the IC (50) +/- SE values of17.15 +/- 0.82 microM for MHH-ES-1 and 11.80 +/- 1.03 microM for MT-3 for 30 hours exerted a clinically significant inhibition of the human sarcoma and breast cancer cell line in a dose-dependent manner.
The finding suggested that Cat's claw may have a chemotherapeutic effect in the prevention and treatment of cancer without inducing any adverse effects.
However, due to the limitation of the above studies, additional data collection large example size and multi-center studies performed with human consumption of the preparations during the course of the disease will be necessary to complete the picture of Cat's claw anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Topical plant database (Rain tree)
(2) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition by Pilarski R, Filip B, Wietrzyk J, Kuraś M, Gulewicz K.(PubMed)
(3) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines, by García Giménez D, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(4) Environmental Factors Inducing Human Cancers by N Parsa. (PMC)
(5) Cancer is a Preventable Disease that Requires Major Lifestyle Changes by Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar,Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal. (PMC)
#Healthyfood #Carrot Gobbles Up Pathogenic Microorganisms in Initiated Cell Infection, Scientists Reveal
By Kyle J. Norton
Carrots may have a profound and positive effect in gobbling up foreign microbial organisms before they can cause infection and damage to the host tissue, some scientists suggested.
The results of the veggie inhibition of micro-bacterial expression in an increased risk of infection were demonstrated by respectable institutes, including Iowa State University and Université de Monastir.
Infectious tissue caused by microbial organisms can induce transmissible disease or communicable diseases through the production of toxins.
The most common symptoms of infection are a fever. This is the result of the reaction of the immune response in stimulated overproduction of pro-inflammatory cytokines to protection the damage or injuries against micro pathogens.
However, over-repression of pro-inflammatory factors can also induce tissue damage and forming of scars.
Other common symptoms also include chills and sweats, cough, sore throat, nasal congestion,....and burning or pain with urination
Some researchers suggested that most people with a balance of antioxidants, produced by tissue enzymes and free radicals are normally performed quite well against microorganisms during the time of infection.
Unluckily, people with a weakened immune system caused by reduced levels of antioxidant enzymes may need to gobble up some anti-inflammatory agents to speed up their recovery.
Conventional antibiotics may be helpful, however, they can cause severe adverse effects.
Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
In the investigation the effect of essential oils extracted from Daucus carota L. (Apiaceae) seeds inhibited the spread of microbial organisms through comparison of 4 volatile compounds β-bisabolene (mean content of 39.33%), sabinene (8.53%), geranyl acetate (7.12%), and elemicin (6.26%), researchers found that application of all compounds exerts strong activity in inhibited expression of Gram-positive (Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Salmonella typhimurium).
The result of efficacy probably was due to carrot seed extract's protection of cell membrane against microorganisms in initiated cell infection
Normally, infectious agents invade the cell membrane as the entry point to alternate DNA of the healthy cells.
In vitro, injection of all major compounds also showed a potential effect against Candida albicans, a pathogenic yeast.
Furthermore, the essential oil of carrot seed extract also exerted a similar antibacterial and antifungal activity compared to the individual compound.
Some researchers suggested that antioxidants may also have a profound effect on the initiated expression of free radical cytotoxicity in facilitated damage and death of microorganisms, particularly in infectious cells.
Interestingly, the precipitated cytotoxicity induced by reactive oxygen species and carrot antioxidants did not cause harm to healthy cells.
Also, the expression of antioxidants in the found compound ameliorated the immune response to protect our body against the stimulation of microorganisms in initiated production of inflammatory cytokines without reduced immune activity.
Overexpression of proinflammation is not only associated with increased symptoms of swelling, pain, and fever but also increased risk of cell damage and apoptosis in the site of infection, leading to abnormal healing skin.
Additionally, in the analysis of the carrot essential oil from flowers and roots of Daucus carota L. ssp. Mauritius obtained by hydrodistillation, researchers at the Université de Monastir reported that out of thirty-two and six compounds were identified in flower and root oils, phenolic derivatives (76.3%), myristicin (31; 29.7%), and dillapiole (32; 46.6%) constituted to main fraction demonstrated most protective effect in the inhibition of a series of common human pathogenic bacteria.
According to the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assays, the found chemical compound also inhibited some clinically and environmentally isolated strains.
The evidence suggested that carrots with abundant bioactive compounds may be used as a functional food for reduced risk and treatment of micro bacterial infection.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Variation of the chemical composition and antimicrobial activity of the essential oils of natural populations of Tunisian Daucus carota L. (Apiaceae) by Rokbeni N1, M'rabet Y, Dziri S, Chaabane H, Jemli M, Fernandez X, Boulila A.(PubMed)
(2) Flower and root oils of the tunisian Daucus carota L. ssp. maritimus (Apiaceae): integrated analyses by GC, GC/MS, and 13C-NMR spectroscopy, and in vitro antibacterial activity by Jabrane A1, Jannet HB, Harzallah-Skhiri F, Mastouri M, Casanova J, Mighri Z.(PubMed)
Carrots may have a profound and positive effect in gobbling up foreign microbial organisms before they can cause infection and damage to the host tissue, some scientists suggested.
The results of the veggie inhibition of micro-bacterial expression in an increased risk of infection were demonstrated by respectable institutes, including Iowa State University and Université de Monastir.
Infectious tissue caused by microbial organisms can induce transmissible disease or communicable diseases through the production of toxins.
The most common symptoms of infection are a fever. This is the result of the reaction of the immune response in stimulated overproduction of pro-inflammatory cytokines to protection the damage or injuries against micro pathogens.
However, over-repression of pro-inflammatory factors can also induce tissue damage and forming of scars.
Other common symptoms also include chills and sweats, cough, sore throat, nasal congestion,....and burning or pain with urination
Some researchers suggested that most people with a balance of antioxidants, produced by tissue enzymes and free radicals are normally performed quite well against microorganisms during the time of infection.
Unluckily, people with a weakened immune system caused by reduced levels of antioxidant enzymes may need to gobble up some anti-inflammatory agents to speed up their recovery.
Conventional antibiotics may be helpful, however, they can cause severe adverse effects.
Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
In the investigation the effect of essential oils extracted from Daucus carota L. (Apiaceae) seeds inhibited the spread of microbial organisms through comparison of 4 volatile compounds β-bisabolene (mean content of 39.33%), sabinene (8.53%), geranyl acetate (7.12%), and elemicin (6.26%), researchers found that application of all compounds exerts strong activity in inhibited expression of Gram-positive (Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Salmonella typhimurium).
The result of efficacy probably was due to carrot seed extract's protection of cell membrane against microorganisms in initiated cell infection
Normally, infectious agents invade the cell membrane as the entry point to alternate DNA of the healthy cells.
In vitro, injection of all major compounds also showed a potential effect against Candida albicans, a pathogenic yeast.
Furthermore, the essential oil of carrot seed extract also exerted a similar antibacterial and antifungal activity compared to the individual compound.
Some researchers suggested that antioxidants may also have a profound effect on the initiated expression of free radical cytotoxicity in facilitated damage and death of microorganisms, particularly in infectious cells.
Interestingly, the precipitated cytotoxicity induced by reactive oxygen species and carrot antioxidants did not cause harm to healthy cells.
Also, the expression of antioxidants in the found compound ameliorated the immune response to protect our body against the stimulation of microorganisms in initiated production of inflammatory cytokines without reduced immune activity.
Overexpression of proinflammation is not only associated with increased symptoms of swelling, pain, and fever but also increased risk of cell damage and apoptosis in the site of infection, leading to abnormal healing skin.
Additionally, in the analysis of the carrot essential oil from flowers and roots of Daucus carota L. ssp. Mauritius obtained by hydrodistillation, researchers at the Université de Monastir reported that out of thirty-two and six compounds were identified in flower and root oils, phenolic derivatives (76.3%), myristicin (31; 29.7%), and dillapiole (32; 46.6%) constituted to main fraction demonstrated most protective effect in the inhibition of a series of common human pathogenic bacteria.
According to the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assays, the found chemical compound also inhibited some clinically and environmentally isolated strains.
The evidence suggested that carrots with abundant bioactive compounds may be used as a functional food for reduced risk and treatment of micro bacterial infection.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Variation of the chemical composition and antimicrobial activity of the essential oils of natural populations of Tunisian Daucus carota L. (Apiaceae) by Rokbeni N1, M'rabet Y, Dziri S, Chaabane H, Jemli M, Fernandez X, Boulila A.(PubMed)
(2) Flower and root oils of the tunisian Daucus carota L. ssp. maritimus (Apiaceae): integrated analyses by GC, GC/MS, and 13C-NMR spectroscopy, and in vitro antibacterial activity by Jabrane A1, Jannet HB, Harzallah-Skhiri F, Mastouri M, Casanova J, Mighri Z.(PubMed)
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