By Kyle J. Norton
Colorectal cancer also known as bowel cancer, is a medical and chronic condition characterized by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix due to the alternation of DNA with unidentified origin.
Colorectal cancer (CRC) is a relatively very common cancer in the Western world. The cancer is considered a slowly growing and progressing cancer in a predictable way.
Bowl is divided into 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food, and the 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Why colorectal cancer is more susceptible to the West than other parts of the world. Some researchers suggested it may be a result of the Western diet. People who a diet with high saturated and trans fats, red meat, processed foods, fewer fruits and vegetables, and whole grains are associated with a substantially higher risk of colorectal cancer, compared to the traditional diet.
Dr. Alan Moss, the lead author in the cancer program at The University of Melbourne, a diet that contains high levels of red meat is associated with the risk of CRC.
The risk of colorectal is increased proportionally to the increased intake of red meat. In other words, the redder consumed the higher the risk of CRC.
And, processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage are also on the list of elevated risk of colorectal cancer.
In the comparison of the “Western” and “prudent” dietary patterns on the incidence of CRC, researchers showed that people who follow the Western diet have a 31% increased risk of the disease onset, compared to a 14% reduced risk of CRC in people who follow the prudent diet with high fruits and vegetables, fewer red meat and processed foods.
These results suggested, regardless to present the colorectal cancer risk, a change of diet pattern today, your risk the cancer is continuously lower, compared to before the change.
Dr, Shafie NH, the lead scientist in the researchers at the cancer program team at the Universiti Putra Malaysia in the examine whether phytic acid, a natural dietary ingredient and an essential component of nutritional diets effect colorectal cancer risk showed that
* Phytic acid exerted a strongly inhibitory colorectal cancer activity by increasing the function of proteins (up-regulation of Bax)associated with program cell death and (down-regulation of Bcl-xl) anti-cancer cell proliferation.
* Furthermore, when exposed to IP6 (phytic acid), the phytochemical up-regulates of caspase-3 and -8 expressions and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells.
Phytic acid, an organic compound found much in healthy food sources may have a potential effect in reducing the risk and treatment of colorectal cancer, some studies suggested.
Foods containing high levels of phytic acid including nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds,...
The results suggested, combined with t rice bran IP6 (phytic acid) induced apoptosis, by regulating the pro- and anti-apoptotic markers.
Moreover, in reaffirming the significant role of phytic acid in the inhibition of colorectal cancer, Dr. Saad N, the team leader, and colleagues launched an investigation of expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence after treatment with rice bran PA by immunocytochemistry.
The experiment includes a total of 72 male Sprague-Dawley rats divided into 6 equal groups with 12 rats in each group.
Cancer induction by two intraperitoneal injections of azoxymethane (AOM) was given at 15 mg/kg body weight over a 2-week period. During the post-initiation phase, two different concentrations of PA, 0.2% (w/v) and 0.5% (w/v) were administered in the diet.
Before treatment with PA, rats-induced cancer showed that β-catenin, a marker of alternation of gene transcription, COX-2 expressions associated with cancer cell proliferation, and cell proliferation of Ki-67 associated with a significant contribution in colonic cancer progression.
And, a significant positive expression and correlation were found between COX-2 expression and proliferation and the total β-catenin also demonstrated a significant positive linear relationship with total COX-2.
After the application of phytic acid, researchers found that the expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence were totally inhibited by rice bran PA.
Taken together, there is no doubt that phytic acid can be considered a functional supplement in the prevention of colorectal cancer and combined with primary therapy for the treatment of the disease without inducing any side effects.
However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of phytic acid anti-colorectal cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Pro-Apoptotic Effect of Rice Bran Inositol Hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells by Shafie NH, Esa NM, Ithnin H, Saad N, Pandurangan AK.(PubMed)
(2) Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice branphytic acid (PA) by Saad N, Esa NM, Ithnin H.(PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations by Alan Moss and Kumanan Nalankilli (Gastroenterology)
Monday, 5 June 2023
#Herbal #Ashwagandha Extract Exerts Cytotoxic and Cytostatic Activities Against Leukemia Cells in Vitro, Studies Show
By Kyle J. Norton
Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
Bone marrow, containing two main types of stem cells is soft tissue inside the hollow center of the major bone, including the spine, pelvis, underarm, and leg. etc. with the main function of generating blood cells.
Believe it or not, the bone marrow produces 200 billion new red blood cells every day, to replace the blood cells that die off, along with white blood cells and platelets.
According to the statistics provided by the leukemia research, leukemia is diagnosed 10 times more often in adults than children. Approximately, each year the disease causes the death of 68,000 Americans.
Acute leukemia is a condition caused by a rapid increase in the number of extremely immature white blood cells which appear in the bloodstream into other parts of the body, including tissue and organs, including acute lymphoblastic leukemia (ALL), acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML).
In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children form of leukemia with about 80% of all cases.
Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells. the condition has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system, including chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of leukemias, researchers explored the antileukemic activity of the dimethyl sulfoxide extract obtained from the roots of W. somnifera (WE).
On a human T-lymphoblastoid cell line, WE exerted a significant cytostatic and cytotoxic activity against the tested cell line observed by the differentiation of the different flow cytometric assays.
Furthermore, WE cytotoxic and cytostatic potential was attributed to the effect involving immunogenic cell death (ICD) observed in dying cancer cells that release damage-associated molecular patterns.
Furthermore, WE also promoted the intracellular Ca(2+) accumulation that alters cancer initiation and the generation of reactive oxygen species to induce cancer cell apoptosis.
In other words, the tested extract processed genotoxic potential. against leukemia cells in vitro.
Based on the findings, researchers said, "Since the use of Withania is suggested in different contexts including anti-infertility and osteoarthritis care, its genotoxicity should be carefully considered for an accurate assessment of its risk-benefit profiles".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of leukemia, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells by Turrini E1, Calcabrini C2, Sestili P3, Catanzaro E4, de Gianni E5, Diaz AR6, Hrelia P7, Tacchini M8, Guerrini A9, Canonico B10, Papa S11, Valdrè G12, Fimognari C. (PubMed)
Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
Bone marrow, containing two main types of stem cells is soft tissue inside the hollow center of the major bone, including the spine, pelvis, underarm, and leg. etc. with the main function of generating blood cells.
Believe it or not, the bone marrow produces 200 billion new red blood cells every day, to replace the blood cells that die off, along with white blood cells and platelets.
According to the statistics provided by the leukemia research, leukemia is diagnosed 10 times more often in adults than children. Approximately, each year the disease causes the death of 68,000 Americans.
Acute leukemia is a condition caused by a rapid increase in the number of extremely immature white blood cells which appear in the bloodstream into other parts of the body, including tissue and organs, including acute lymphoblastic leukemia (ALL), acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML).
In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children form of leukemia with about 80% of all cases.
Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells. the condition has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system, including chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of leukemias, researchers explored the antileukemic activity of the dimethyl sulfoxide extract obtained from the roots of W. somnifera (WE).
On a human T-lymphoblastoid cell line, WE exerted a significant cytostatic and cytotoxic activity against the tested cell line observed by the differentiation of the different flow cytometric assays.
Furthermore, WE cytotoxic and cytostatic potential was attributed to the effect involving immunogenic cell death (ICD) observed in dying cancer cells that release damage-associated molecular patterns.
Furthermore, WE also promoted the intracellular Ca(2+) accumulation that alters cancer initiation and the generation of reactive oxygen species to induce cancer cell apoptosis.
In other words, the tested extract processed genotoxic potential. against leukemia cells in vitro.
Based on the findings, researchers said, "Since the use of Withania is suggested in different contexts including anti-infertility and osteoarthritis care, its genotoxicity should be carefully considered for an accurate assessment of its risk-benefit profiles".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of leukemia, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells by Turrini E1, Calcabrini C2, Sestili P3, Catanzaro E4, de Gianni E5, Diaz AR6, Hrelia P7, Tacchini M8, Guerrini A9, Canonico B10, Papa S11, Valdrè G12, Fimognari C. (PubMed)
#Herbal #Catsclaw Inhibits the Risk of Diseases Associated with Overexpression of Oxidativestress, Scientists Say
By Kyle J. Norton
Herbal Cat'claw may process a potential effect in balancing the ratio of free radicals and antioxidants in the body, some scientists suggested.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative, or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.
The imbalance of the ratio of free radicals and antioxidants linked to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, and certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states, or reduced levels of antioxidant enzymes in the human.
In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence the application of an external source of antioxidants can assist in coping with this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
The results clearly indicated, if our body can not produce the levels of antioxidants to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from foods, herbs, and synthetic sources may be necessary.
Some researchers also suggested that antioxidants from food and herbal sources have been found to exert a significant effect in stimulating the antioxidants produced by the host tissue.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer, and diseases of the urinary tract, etc.
In the aim to reaffirm the traditional use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavonols isolated from the herb.
In vitro, the application of alkaloids and flavonols isolated from the herb demonstrated the significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.
The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.
Oral pretreatment for 3 d with UT protected against indomethacin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis.
This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine
Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).
The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.
From the immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes by over the control value along with a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).
Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.
* The alcoholic preparations exert higher antioxidant activity and total phenolic compounds compared
Although alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.
Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity and may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for the treatment of overexpression of oxidative stress-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
Herbal Cat'claw may process a potential effect in balancing the ratio of free radicals and antioxidants in the body, some scientists suggested.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative, or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.
The imbalance of the ratio of free radicals and antioxidants linked to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, and certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states, or reduced levels of antioxidant enzymes in the human.
In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence the application of an external source of antioxidants can assist in coping with this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
The results clearly indicated, if our body can not produce the levels of antioxidants to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from foods, herbs, and synthetic sources may be necessary.
Some researchers also suggested that antioxidants from food and herbal sources have been found to exert a significant effect in stimulating the antioxidants produced by the host tissue.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer, and diseases of the urinary tract, etc.
In the aim to reaffirm the traditional use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavonols isolated from the herb.
In vitro, the application of alkaloids and flavonols isolated from the herb demonstrated the significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.
The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.
Oral pretreatment for 3 d with UT protected against indomethacin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis.
This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine
Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).
The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.
From the immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes by over the control value along with a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).
Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.
* The alcoholic preparations exert higher antioxidant activity and total phenolic compounds compared
Although alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.
Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity and may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for the treatment of overexpression of oxidative stress-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
#Herbal #CascaraSagrada Processes Anti-Bacterial Activities, According to Studies
By Kyle J. Norton
Herbal Cascara sagrada processed with a bioactive compound emodin may have a potential and profound effect on reducing the risk and treatment of bacterial infection, according to studies.
According to the statistic, infectious diseases caused the death of 9.2 million deaths in 2013 worldwide, representing 17% of all deaths.
The bacterial infection is a result of the battle of the immune system against the multiplication of bacteria in some selected tissue or organ by the pathogens after scaping the assault of white blood cells in the first line of immune defense.
Bacterial infection can be caused by the spread through an infected person coughing and sneezing and contact with infected people or contaminated surfaces, food, and water.
However, the most common risk factors of bacterial infection are tissue damage or injury. Believe it or not, most bacteria try to enter the body through wounds that are killed off during the acute phase of infection.
In the early phase, the immune not only stimulates the blood vessel's constriction to produce a palette to cover the wound but also activates the production of proinflammatory cytokines to the site of the damage with an aim to kill off all the micro-invaders.
The most common conventional medicine for the treatment of bacterial infection is an injection of antibiotics.
Due to the overuse of such medication, some bacteria have developed antibiotics resistances, such as Staphylococcus aureus ('golden staph' or MRSA) and Neisseria gonorrhoeae are now resistant to benzylpenicillin.
New antibiotics may be effective, however, they can induce some side effects. Please make sure you discuss the adverse effects with your doctor if you are currently taking some antibiotics for the treatment of infection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural ingredient to treat bacterial infection examined the effects of emodin against Methicillin-resistant Staphylococcus aureus (MRSA), a substantial contributor to morbidity and mortality.
In 17 different strains of the bacterium selected for the study, the combined activity of EM and two antimicrobial agents (AM, OX) against all strains resulted in a fractional inhibitory concentration index (FICI) ranging from 0.37-0.5 and from 0.37-0.75, respectively.
The effect of EM with AM and OX was found to be synergistic or partially synergistic.
Furthermore, EM reduced the minimum inhibitory concentrations of AM and OX. EM against MRSA infection.
In the comparison of the antibacterial effects of aloe-emodin and aloe and its contents of anthraquinone compounds, researchers evaluated the antibacterial activities of the extracts from the outer leaf of Aloe saponaria Haw, aloin and aloe-emodin against three Gram-negative and two Gram-positive bacteria
Anthraquinone and aloin exhibited higher antibacterial activity inhibition diameter > (7. 1 +/- 0.15) mm] than Aloe-emodin.
The antibacterial activity of Aloe was attributed to the concentration of anthraquinone, aloin in a dose-dependent manner.
The results clearly suggested that Aloe-emodin exerts a significant antibacterial effect to a lesser extent compared to levels of anthraquinone, aloin.
Taken altogether, herbal Cascara Sagrada processed with a high amount of emodin may be considered an alternative antibiotic for the treatment of bacterial infection, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References(1) Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.by Lee YS, Kang OH, Choi JG, Oh YC, Keum JH, Kim SB, Jeong GS, Kim YC, Shin DW, Kwon DY.(PubMed)
(2) [Relationship between antibacterial activity of aloe and its anthaquinone compounds].[Article in Chinese] by Tian B, Hua YJ, Ma XQ, Wang GL.(PubMed)
Herbal Cascara sagrada processed with a bioactive compound emodin may have a potential and profound effect on reducing the risk and treatment of bacterial infection, according to studies.
According to the statistic, infectious diseases caused the death of 9.2 million deaths in 2013 worldwide, representing 17% of all deaths.
The bacterial infection is a result of the battle of the immune system against the multiplication of bacteria in some selected tissue or organ by the pathogens after scaping the assault of white blood cells in the first line of immune defense.
Bacterial infection can be caused by the spread through an infected person coughing and sneezing and contact with infected people or contaminated surfaces, food, and water.
However, the most common risk factors of bacterial infection are tissue damage or injury. Believe it or not, most bacteria try to enter the body through wounds that are killed off during the acute phase of infection.
In the early phase, the immune not only stimulates the blood vessel's constriction to produce a palette to cover the wound but also activates the production of proinflammatory cytokines to the site of the damage with an aim to kill off all the micro-invaders.
The most common conventional medicine for the treatment of bacterial infection is an injection of antibiotics.
Due to the overuse of such medication, some bacteria have developed antibiotics resistances, such as Staphylococcus aureus ('golden staph' or MRSA) and Neisseria gonorrhoeae are now resistant to benzylpenicillin.
New antibiotics may be effective, however, they can induce some side effects. Please make sure you discuss the adverse effects with your doctor if you are currently taking some antibiotics for the treatment of infection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural ingredient to treat bacterial infection examined the effects of emodin against Methicillin-resistant Staphylococcus aureus (MRSA), a substantial contributor to morbidity and mortality.
In 17 different strains of the bacterium selected for the study, the combined activity of EM and two antimicrobial agents (AM, OX) against all strains resulted in a fractional inhibitory concentration index (FICI) ranging from 0.37-0.5 and from 0.37-0.75, respectively.
The effect of EM with AM and OX was found to be synergistic or partially synergistic.
Furthermore, EM reduced the minimum inhibitory concentrations of AM and OX. EM against MRSA infection.
In the comparison of the antibacterial effects of aloe-emodin and aloe and its contents of anthraquinone compounds, researchers evaluated the antibacterial activities of the extracts from the outer leaf of Aloe saponaria Haw, aloin and aloe-emodin against three Gram-negative and two Gram-positive bacteria
Anthraquinone and aloin exhibited higher antibacterial activity inhibition diameter > (7. 1 +/- 0.15) mm] than Aloe-emodin.
The antibacterial activity of Aloe was attributed to the concentration of anthraquinone, aloin in a dose-dependent manner.
The results clearly suggested that Aloe-emodin exerts a significant antibacterial effect to a lesser extent compared to levels of anthraquinone, aloin.
Taken altogether, herbal Cascara Sagrada processed with a high amount of emodin may be considered an alternative antibiotic for the treatment of bacterial infection, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References(1) Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.by Lee YS, Kang OH, Choi JG, Oh YC, Keum JH, Kim SB, Jeong GS, Kim YC, Shin DW, Kwon DY.(PubMed)
(2) [Relationship between antibacterial activity of aloe and its anthaquinone compounds].[Article in Chinese] by Tian B, Hua YJ, Ma XQ, Wang GL.(PubMed)
#CommonPeas (#DriedPeas) In the Promotion of Immunomodulating Activity, Researchers Say
By Kyle J. Norton
Intake of common (dried) peas daily and regularly may have a potential effect in enhanced immunomodulating activity, scientists at some renowned institute studies suggested.
The dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with a healthy source of proteins, fibers, vitamins, and minerals.
Immunomodulation is an action with a profound and positive effect on regulated immune response and function through the activation of antibody formation or the inhibition of white blood cell activity.
In the evaluation of 173 LAB strains, including the strain NTM048 isolated from green peas having the ability to induce IgA production using murine Peyer's patch cells, researchers at the Ishikawa Prefectural University, after taking account of other confounders suggested that
1. Strain NTM048 isolated from green peas demonstrated a higher immunomodulating activity in compared to other straits.
2. The green pea strait also is well tolerated in gastrointestinal digestion and produces large amounts of exopolysaccharides, high-molecular-weight polymers that have been used in conventional medicine for the prospect of anticoagulant, antithrombotic, immunomodulation, anticancer and as flocculants.
3. Application of the strait also induced a significant increase in the fecal IgA content and plasma IgA levels in response to the immunogen of BALB/cA mice
Further analysis of the function of the strait isolated from green peas, researchers emphasized that the strait has a significant impact in stimulating immunomodulating activities through regulating the transforming growth factor-β in the secretion of inflammatory cytokines which plays an important role in the control of cell growth, cell proliferation, cell differentiation, and apoptosis.
The action of the strait in the activation of immunomodulating activity was also attributed to stimulating Peyer's patch cells which are aggregated in lymphoid nodules, and formed an important part of the immune system.
The information findings prompted Dr. Matsuzaki C, the lead author to suggest, "Strain NTM048 stimulates Peyer's patch cells to induce an intestinal and systemic immune response, revealing the potential of NTM048 as a probiotic for enhancing the mucosal barrier function".
The collective information of NTM048 as a probiotic may be helpful to reduce symptoms and treatments of people with digestive disorders by including portions of green peas or dried peas in their daily diet.
Additionally, in another field of study, researchers at the University of Ottawa launched an investigation of the immunomodulating activity of enzymatic protein hydrolysates of yellow peas using a murine model indicating that
1. Oral administration of Pea protein hydrolysate, after a 12 h pre-treatment, showed significant inhibition of free radical NO production by activating increased mobile white blood cells by 20%.
The reduction of ROS may be a result of overexpression of antioxidant production in stimulated immunomodulating effect to protect against localized tissue and injure against infection and inflammation caused by foreign pathogens.
2. The injection also showed a strongly inhibited secretion of pro-inflammatory cytokines, TNF-α- and IL-6, in a range of 35 and 80%, respectively.
TNF-α, Tumor necrosis factor is a protein with function in initiated response in the acute phase of inflammation
IL-6 (Interleukin 6) secreted by the immune system to stimulate an immune response, is an interleukin with duo functions in promoting either pro and anti-inflammatory cytokines respectively.
The inhibition of the pro-inflammatory substance of the pea protein may have a potential effect in reduced symptoms and complications such as reddened, swollen, hot, and often painful in the location of injury or infection.
3. The protein also stimulated the gut mucosal immune response.
The gut mucosal immune response against harmful intestinal organisms has a strong impact in reducing the risk of digestive disorders, by regulating the function of lymphoid tissue located in the mucosa.
According to the article on mucosal immunology, "the mucosal immune system provides protection against pathogens but maintains a tolerance towards non-harmful commensal microbes and benign environmental substances".
4. The immunomodulating effect is also found in an increased number of IgA+ cells in the small intestine lamina propria accompanied by an increase in the number of IL-4+, IL-10+, and IFN-γ+ cells.
In this case, the immunomodulating effect through the expression of the production of IgA+ cells in
protected the intestine lamina propria(based membrane) from pathogens, toxins, and food antigens in the basement remembrance of the intestine by increasing the numbers of interleukin IL-4+, and IL-10+ in inhibited production of pro-inflammatory cytokines as well as the increased function of IFN-γ+ cells in stimulating innate and adaptive immunity against viral, some bacterial and protozoal infections.
Further differentiation also suggested that the enhanced IL-6 secretion of small intestine epithelial cells (IEC) by the Pea protein hydrolysate in stimulation IgA-secretion, probably associated with a number of mechanisms, particularly in TLR2 and TLR4 function in pathogen recognition and activation of innate immunity.
Taking all together, green peas or common peas may be considered a therapeutic treatment in enhanced immunomodulating activity, particularly for aging adults and people with a history of weakened immunity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Immunomodulating activity of exopolysaccharide-producing Leuconostoc mesenteroides strain NTM048 from green peas by Matsuzaki C1, Kamishima K, Matsumoto K, Koga H, Katayama T, Yamamoto K, Hisa K.(PubMed)
(2)Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds by Ndiaye F1, Vuong T, Duarte J, Aluko RE, Matar C.(PubMed)
(3) Mucosal immunology by Nature.com
Intake of common (dried) peas daily and regularly may have a potential effect in enhanced immunomodulating activity, scientists at some renowned institute studies suggested.
The dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with a healthy source of proteins, fibers, vitamins, and minerals.
Immunomodulation is an action with a profound and positive effect on regulated immune response and function through the activation of antibody formation or the inhibition of white blood cell activity.
In the evaluation of 173 LAB strains, including the strain NTM048 isolated from green peas having the ability to induce IgA production using murine Peyer's patch cells, researchers at the Ishikawa Prefectural University, after taking account of other confounders suggested that
1. Strain NTM048 isolated from green peas demonstrated a higher immunomodulating activity in compared to other straits.
2. The green pea strait also is well tolerated in gastrointestinal digestion and produces large amounts of exopolysaccharides, high-molecular-weight polymers that have been used in conventional medicine for the prospect of anticoagulant, antithrombotic, immunomodulation, anticancer and as flocculants.
3. Application of the strait also induced a significant increase in the fecal IgA content and plasma IgA levels in response to the immunogen of BALB/cA mice
Further analysis of the function of the strait isolated from green peas, researchers emphasized that the strait has a significant impact in stimulating immunomodulating activities through regulating the transforming growth factor-β in the secretion of inflammatory cytokines which plays an important role in the control of cell growth, cell proliferation, cell differentiation, and apoptosis.
The action of the strait in the activation of immunomodulating activity was also attributed to stimulating Peyer's patch cells which are aggregated in lymphoid nodules, and formed an important part of the immune system.
The information findings prompted Dr. Matsuzaki C, the lead author to suggest, "Strain NTM048 stimulates Peyer's patch cells to induce an intestinal and systemic immune response, revealing the potential of NTM048 as a probiotic for enhancing the mucosal barrier function".
The collective information of NTM048 as a probiotic may be helpful to reduce symptoms and treatments of people with digestive disorders by including portions of green peas or dried peas in their daily diet.
Additionally, in another field of study, researchers at the University of Ottawa launched an investigation of the immunomodulating activity of enzymatic protein hydrolysates of yellow peas using a murine model indicating that
1. Oral administration of Pea protein hydrolysate, after a 12 h pre-treatment, showed significant inhibition of free radical NO production by activating increased mobile white blood cells by 20%.
The reduction of ROS may be a result of overexpression of antioxidant production in stimulated immunomodulating effect to protect against localized tissue and injure against infection and inflammation caused by foreign pathogens.
2. The injection also showed a strongly inhibited secretion of pro-inflammatory cytokines, TNF-α- and IL-6, in a range of 35 and 80%, respectively.
TNF-α, Tumor necrosis factor is a protein with function in initiated response in the acute phase of inflammation
IL-6 (Interleukin 6) secreted by the immune system to stimulate an immune response, is an interleukin with duo functions in promoting either pro and anti-inflammatory cytokines respectively.
The inhibition of the pro-inflammatory substance of the pea protein may have a potential effect in reduced symptoms and complications such as reddened, swollen, hot, and often painful in the location of injury or infection.
3. The protein also stimulated the gut mucosal immune response.
The gut mucosal immune response against harmful intestinal organisms has a strong impact in reducing the risk of digestive disorders, by regulating the function of lymphoid tissue located in the mucosa.
According to the article on mucosal immunology, "the mucosal immune system provides protection against pathogens but maintains a tolerance towards non-harmful commensal microbes and benign environmental substances".
4. The immunomodulating effect is also found in an increased number of IgA+ cells in the small intestine lamina propria accompanied by an increase in the number of IL-4+, IL-10+, and IFN-γ+ cells.
In this case, the immunomodulating effect through the expression of the production of IgA+ cells in
protected the intestine lamina propria(based membrane) from pathogens, toxins, and food antigens in the basement remembrance of the intestine by increasing the numbers of interleukin IL-4+, and IL-10+ in inhibited production of pro-inflammatory cytokines as well as the increased function of IFN-γ+ cells in stimulating innate and adaptive immunity against viral, some bacterial and protozoal infections.
Further differentiation also suggested that the enhanced IL-6 secretion of small intestine epithelial cells (IEC) by the Pea protein hydrolysate in stimulation IgA-secretion, probably associated with a number of mechanisms, particularly in TLR2 and TLR4 function in pathogen recognition and activation of innate immunity.
Taking all together, green peas or common peas may be considered a therapeutic treatment in enhanced immunomodulating activity, particularly for aging adults and people with a history of weakened immunity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Immunomodulating activity of exopolysaccharide-producing Leuconostoc mesenteroides strain NTM048 from green peas by Matsuzaki C1, Kamishima K, Matsumoto K, Koga H, Katayama T, Yamamoto K, Hisa K.(PubMed)
(2)Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds by Ndiaye F1, Vuong T, Duarte J, Aluko RE, Matar C.(PubMed)
(3) Mucosal immunology by Nature.com
#Kale #Supplement in the Prevention of #Hypertension, According to Clinical Trials
By Kyle J. Norton
Hypertension or high blood pressure, a condition associated with the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and changes constantly depending on activity. However, persistent hypertension due to poor management over time can lead to cardiovascular disease.
According to the statistics provided by the American Heart Association., nearly half of all adults in the United States are living with high blood pressure, or 1 in 3 Americans are hypertensive.
Hypertension is the leading risk factor of heart disease and stroke in the US.
Cardiovascular diseases (CVD) including heart disease and stroke are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.
According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015 were in men, comapred to women.
Believe it or not, more than 63,000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.
Most common prevalent factors associated with the hypertension onset are family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet and medical condition such as chronic kidney disease.
Excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.
Depending on the levels of blood pressure, most people with mild hypertension are asymptomatic. However, unmanaged high blood pressure can induce complications of heart attack or stroke, heart failure, weakened and narrowed blood vessels, metabolic syndrome, and trouble with memory or understanding,
Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications has caused many side effects such as damaging the kidney.
Some researchers suggested by making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
Dr. L. J. Beilin wrote, "Lifestyle factors are critical determinants of blood pressure levels operating against a background of genetic susceptibility. Excess body fat is a predominant cause of hypertension with additive effects of dietary salt, alcohol, and physical inactivity."
And "Controlled trials in hypertensives show blood pressure lowering effects of supplemental potassium, fiber, n-3 fatty acids, and diets rich in fruit and vegetables and low in saturated fats".
With an aim to find a natural food for the prevention and treatment of hypertension, researchers examined the effect of daily supplementation of kale juice can modulate blood pressure (BP).
The study included 84 subclinical hypertensive patients with systolic BP over 130 mmHg or diastolic BP over 85 mmHg who received 300 ml/day of kale juice for 6 weeks.
According to the blood samples obtained on 0-week and 6-week, kale supplements showed a significantly decreased systolic and diastolic blood pressure in all patients regardless of their GSTM1 or GSTT1 polymorphisms.
According to the joint study led by the Isfahan University of Medical Sciences, GSTT1 and GSTM1 gene increases the arterial pressure; hence, it can predict the susceptibility to cardiovascular disease.
In other words, kale supplements inhibited the hyperactive parameters without being affected by the gene expression of GSTM1 or GSTT1 polymorphisms.
Furthermore, kale supplement exerted no effect on plasma lipid profiles of patients with GSTM1-null and GSTM1-present genotypes.
More importantly, the supplement also increased plasma HDL-C and lowered LDL-C in the GSTT1-present type, while blood glucose was decreased only in the GSTT1-null genotype.
Based on the findings, researchers suggested, kale processes a strong effect in lowering blood pressure through other mechanisms, regardless of GSTT1 and GSTM1 gene types.
Taken altogether, kale juice may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of glutathione S-transferase M1 and T1 polymorphisms on blood pressure, blood glucose, and lipid profiles following the supplementation of kale (Brassica oleracea acephala) juice in South Korean subclinical hypertensive patients by Han JH1, Lee HJ1, Kim TS2, Kang MH. (PubMed)
(2) Association of GSTT1 and GSTM1 polymorphisms with blood pressure: A Bayesian modeling of continuous data by Laleh Rafee, Mahsa Abedini,1 Shaghayegh Haghjooy Javanmard, Nizal Sarrafzadegan,2 and Marjan Mansourian. (PubMed)
(3) Lifestyle and hypertension by L. J. Beilin, I. B. Puddey, V. Burke. (the American Journal of Hypertension)
Hypertension or high blood pressure, a condition associated with the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and changes constantly depending on activity. However, persistent hypertension due to poor management over time can lead to cardiovascular disease.
According to the statistics provided by the American Heart Association., nearly half of all adults in the United States are living with high blood pressure, or 1 in 3 Americans are hypertensive.
Hypertension is the leading risk factor of heart disease and stroke in the US.
Cardiovascular diseases (CVD) including heart disease and stroke are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.
According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015 were in men, comapred to women.
Believe it or not, more than 63,000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.
Most common prevalent factors associated with the hypertension onset are family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet and medical condition such as chronic kidney disease.
Excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.
Depending on the levels of blood pressure, most people with mild hypertension are asymptomatic. However, unmanaged high blood pressure can induce complications of heart attack or stroke, heart failure, weakened and narrowed blood vessels, metabolic syndrome, and trouble with memory or understanding,
Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications has caused many side effects such as damaging the kidney.
Some researchers suggested by making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
Dr. L. J. Beilin wrote, "Lifestyle factors are critical determinants of blood pressure levels operating against a background of genetic susceptibility. Excess body fat is a predominant cause of hypertension with additive effects of dietary salt, alcohol, and physical inactivity."
And "Controlled trials in hypertensives show blood pressure lowering effects of supplemental potassium, fiber, n-3 fatty acids, and diets rich in fruit and vegetables and low in saturated fats".
With an aim to find a natural food for the prevention and treatment of hypertension, researchers examined the effect of daily supplementation of kale juice can modulate blood pressure (BP).
The study included 84 subclinical hypertensive patients with systolic BP over 130 mmHg or diastolic BP over 85 mmHg who received 300 ml/day of kale juice for 6 weeks.
According to the blood samples obtained on 0-week and 6-week, kale supplements showed a significantly decreased systolic and diastolic blood pressure in all patients regardless of their GSTM1 or GSTT1 polymorphisms.
According to the joint study led by the Isfahan University of Medical Sciences, GSTT1 and GSTM1 gene increases the arterial pressure; hence, it can predict the susceptibility to cardiovascular disease.
In other words, kale supplements inhibited the hyperactive parameters without being affected by the gene expression of GSTM1 or GSTT1 polymorphisms.
Furthermore, kale supplement exerted no effect on plasma lipid profiles of patients with GSTM1-null and GSTM1-present genotypes.
More importantly, the supplement also increased plasma HDL-C and lowered LDL-C in the GSTT1-present type, while blood glucose was decreased only in the GSTT1-null genotype.
Based on the findings, researchers suggested, kale processes a strong effect in lowering blood pressure through other mechanisms, regardless of GSTT1 and GSTM1 gene types.
Taken altogether, kale juice may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of glutathione S-transferase M1 and T1 polymorphisms on blood pressure, blood glucose, and lipid profiles following the supplementation of kale (Brassica oleracea acephala) juice in South Korean subclinical hypertensive patients by Han JH1, Lee HJ1, Kim TS2, Kang MH. (PubMed)
(2) Association of GSTT1 and GSTM1 polymorphisms with blood pressure: A Bayesian modeling of continuous data by Laleh Rafee, Mahsa Abedini,1 Shaghayegh Haghjooy Javanmard, Nizal Sarrafzadegan,2 and Marjan Mansourian. (PubMed)
(3) Lifestyle and hypertension by L. J. Beilin, I. B. Puddey, V. Burke. (the American Journal of Hypertension)
#Healthyfood #Cranberry Inhibits #LungCancer Cells Proliferation Through Cell Cycle Arrests, Researchers Find
By Kyle J. Norton
The lung-formed part of the respiratory system is a vital organ located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream and exhaling carbon dioxide from the bloodstream.
Lung diseases are a class of conditions associated with reduced function of the lung, including lung cancer.
Lung cancer is a medical condition associated with abnormal growth of the cells in the lung's tissue that begins in the cells on the surface of the inner lining tissues of the lung due to the alternation of cell DNA.
The most common form of primary lung cancer is derived from epithelial cells.
In the US, lung cancer is the leading cause of cancer deaths. According to the statistics from the American Cancer Society, in 2019, about 228,150 new cases of lung cancer, including 116,440 in men and 111,710 in women will be diagnosed in the US.
Sadly, lung cancer also causes the death of 142,670 American death, including 76,650 in men and 66,020 in women in the same year.
The lifetime risk of lung cancer in a man is 6.7% compared to 5.9% in a woman.
The exact causes of lung cancer are not known. However, epidemiologically, smoking tobacco, second-hand smoke, radon, asbestos, occupational exposure to certain chemicals, personal or family history of lung cancer and lung disease and exposure to radiation are some major factors found in patients with lung cancer.
Dr. Ozlü T, the lead scientist wrote, " Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers. Environmental cigarette smoke exposure and different types of smoking have been shown to cause pulmonary carcinoma. DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the protection of lung cell integrity, researchers examined the effect of the efficacy of proanthocyanidin-rich cranberry fraction (PAC) on lung cancer.
According to the tested analysis, NCI-H460 human lung cancer cells treated with 50 µg/mL PAC or vehicle for 6 hours, PAC exerted a significant activity in the regulation of apoptosis, regulation of programmed cell death, positive regulation of cell death, positive regulation of apoptosis, and apoptotic mitochondrial changes.
Moreover, also NCI-H460 human lung cancer cells treated with 50 µg/mL PAC showed a strong effect on cancer cell metabolism, protein modifications, and cell cycle by inhibiting the M phase of the mitotic cell cycle, mitosis, M phase, cell cycle checkpoint, and regulation of cell cycle process.
More precisely, PAC-induced lung cancer cell apoptosis and anti-proliferative activity through cell cycle arrest.
Furthermore, PAC treatment also enhanced the levels of glutathione S-transferases associated
with blocking cancer cell metastasis.
PAC treatment also down-regulated DNA metabolism, cell cycle, meiosis, mitosis, and interestingly oncogenesis signaling.
PAC treatment also inhibited the alternation of ErbB receptors and signaling pathways and mTOR signaling pathways mutated in lung tumors, involved in cancer development and progression
Taken altogether, cranberry used in conjunction with other remedies may be considered a remedy for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis by Kresty LA1, Howell AB, Baird M. (PubMed)
(2) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
The lung-formed part of the respiratory system is a vital organ located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream and exhaling carbon dioxide from the bloodstream.
Lung diseases are a class of conditions associated with reduced function of the lung, including lung cancer.
Lung cancer is a medical condition associated with abnormal growth of the cells in the lung's tissue that begins in the cells on the surface of the inner lining tissues of the lung due to the alternation of cell DNA.
The most common form of primary lung cancer is derived from epithelial cells.
In the US, lung cancer is the leading cause of cancer deaths. According to the statistics from the American Cancer Society, in 2019, about 228,150 new cases of lung cancer, including 116,440 in men and 111,710 in women will be diagnosed in the US.
Sadly, lung cancer also causes the death of 142,670 American death, including 76,650 in men and 66,020 in women in the same year.
The lifetime risk of lung cancer in a man is 6.7% compared to 5.9% in a woman.
The exact causes of lung cancer are not known. However, epidemiologically, smoking tobacco, second-hand smoke, radon, asbestos, occupational exposure to certain chemicals, personal or family history of lung cancer and lung disease and exposure to radiation are some major factors found in patients with lung cancer.
Dr. Ozlü T, the lead scientist wrote, " Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers. Environmental cigarette smoke exposure and different types of smoking have been shown to cause pulmonary carcinoma. DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the protection of lung cell integrity, researchers examined the effect of the efficacy of proanthocyanidin-rich cranberry fraction (PAC) on lung cancer.
According to the tested analysis, NCI-H460 human lung cancer cells treated with 50 µg/mL PAC or vehicle for 6 hours, PAC exerted a significant activity in the regulation of apoptosis, regulation of programmed cell death, positive regulation of cell death, positive regulation of apoptosis, and apoptotic mitochondrial changes.
Moreover, also NCI-H460 human lung cancer cells treated with 50 µg/mL PAC showed a strong effect on cancer cell metabolism, protein modifications, and cell cycle by inhibiting the M phase of the mitotic cell cycle, mitosis, M phase, cell cycle checkpoint, and regulation of cell cycle process.
More precisely, PAC-induced lung cancer cell apoptosis and anti-proliferative activity through cell cycle arrest.
Furthermore, PAC treatment also enhanced the levels of glutathione S-transferases associated
with blocking cancer cell metastasis.
PAC treatment also down-regulated DNA metabolism, cell cycle, meiosis, mitosis, and interestingly oncogenesis signaling.
PAC treatment also inhibited the alternation of ErbB receptors and signaling pathways and mTOR signaling pathways mutated in lung tumors, involved in cancer development and progression
Taken altogether, cranberry used in conjunction with other remedies may be considered a remedy for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis by Kresty LA1, Howell AB, Baird M. (PubMed)
(2) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
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