#Herbal #Andrographis Reduces the Risk of Cognitive Impairment Throught Its #Antioxidant Activities, Researchers Show

By Kyle J. Norton

Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, and upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ...
Cognitive impairment is considered an early stage of dementia related to the progression of aging.

Andrographis paniculata (Burm. F.) Wall. Ex Nees (Acanthaceae), the forgotten herbal medicine may have a potential effect in reducing the early brain cell damage in the expression of cognitive impairment, a renowned institute study suggested.

According to the joint study led by the Indian Institute of Technology (Banaras Hindu University),
Andrographolide extracts isolated from the herb exhibited a significant property against diabetes-associated cognitive deficits, increased acetylcholinesterase activity, and deteriorated antioxidative status which can increase the risk of cognitive impairment.

In the study of Streptozotocin-induced diabetic Charles Foster albino rats treated orally with a hydro-methanolic A. paniculata leaf extract (50, 100, and 200 mg/kg/day), or with pure andrographolide (15, 30, and 60 mg/kg/day) for 10 consecutive days, the group treated showed an increased level of antioxidants such as superoxide dismutase (SOD), and catalase (CAT) and decreased lipid peroxidation (LPO) in brain tissues.

Dr. the lead author said, "AP or andrographolide treatments dose-dependently attenuated cognitive deficits, reduced acetylcholinesterase activity, oxidative stress, improved diabetic hyperglycemia, and insulin deficiency".

In the social species, Octodon degus (degu) developed Alzheimer's-like pathology with age, oral administration of (Andrographolide, ANDRO), to aged degus (56-month old) for 3 months in comparison to administrated saline of control groups (young degus: 12 months old and aged degus: 56-month old), showed a strong effect on the recovery of spatial memory and learning performance and protection of brain tissues against plague accumulation in inducing brain neural damage associated with aging processes.

In support of the above analysis, the study of "Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice" suggested that the efficacy of the herbal medicine not only protects the long-term potentiation (LTP) against the damage induced by Aβ oligomers but also prevent the changes in neuropathology in tested subjects.

In fact, ANDRO also reduced the Aβ levels, changing the ontogeny of amyloid plaques, and tau phosphorylation in regulated brain cell survival around the Aβ oligomeric species.

There is no doubt that Andrographis paniculata may have a pharmaceutical value in treating cognitive impairment, further large sample size and multi centers studies are necessary.


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Sources
(1) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus).by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(2) Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats by Thakur AK1, Rai G2, Chatterjee SS3, Kumar V1.(PubMed)
(3) Andrographolide reduces cognitive impairment in young and matures AβPPswe/PS-1 mice by Serrano FG1, Tapia-Rojas C2, Carvajal FJ3, Hancke J4, Cerpa W5, Inestrosa NC6,7,8,9,10,11(PubMed)

#Healthyfood #BlackBean Inhibits the Pro-Inflammatory Cytokines that Cause #Colitis, Researchers Say

By Kyle J. Norton

Black beans with abundant chemical constituents and fiber may be considered functional foods for the prevention and treatment of colitis, a renowned institute indicated.
Colitis is a medical condition of inflammation of the inner lining of the colon.

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was the first domesticated growth in South America.

According to the joint study led by the University of Guelph, in vivo, cooked whole-bean flours, with differing phenolic compound levels and profiles, showing a completed inhibition of colitis in a mouse model.


In C57BL/6 mice fed a 20 % navy bean or black bean flour-containing diet or an isoenergetic basal diet (BD) for 2 weeks before the induction of experimental colitis via 7 d dextran sodium sulfate (DSS, 2 % (w/v) in the drinking water) exposure, coincidentally, both groups exerted similarly beneficial and adverse effects in induced locally and systemically while aggravating colonic mucosal damage with unknown identity and systemic inflammation.

In the bean treatment group, the efficacy in ameliorated colitis may be a result of the inhibition of pro-inflammatory expressions, such as colonic inflammatory cytokines (IL-6, IL-9, IFN-γ, and IL-17A) and increased anti-inflammatory IL-10.

In mice with colon inflammation triggered by high-fat diet (HD)-induced obesity, injection of black bean expressed significantly decreased the concentrations of lipid and various circulating proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in mice with HD-induced obesity, in attenuated change associated to colon inflammation.

Furthermore, mice treated with black bean also improved antioxidant status in reduced progression
of reactive oxygen species (ROS) in the induction of oxidative stress.

Dr. Yook JS, the lead researcher said, "BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-κB to decrease the production of proinflammatory cytokines".

Taken together, the black bean may be considered a functional diet in reducing the risk of colitis in high-risk healthy subjects and treatment of patients with colitis with little or no adverse effects.


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Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA1.(PubMed)

#Herbal #Cinnamon Exihibits the Statistically Significant Decrease in Levels of Fasting Plasma Glucose in #Diabetes, Clinical Trials Suggest

By Kyle J. Norton

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professionals because of its anti-diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce blood sugar significantly with little or no adverse side effects.

The herb has been used in herbal and traditional medicine as an anti-fungal and bacteria level to improve the reproductive organ, prevent flatulence and intestinal cramping, and treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a reduction significant of blood triglyceride levels even in the low-dose group, after 3 months of oral administration(2)

Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering insulin secretion, through lower triglyceride and increased liver glycogen content, and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed that "the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism"(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomum cassia) indicated an improvement of glucose, insulin, cholesterol, and HbA1c in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose but insisted that a high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

In a randomized clinical trial in which 70 patients with type II diabetes were assigned randomly to two groups (35 in cinnamon and 35 in the placebo group the testing of the effect of cinnamon on the glucose level in the blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

Taken altogether, cinnamon in a low dose may be effective in controlling the levels of blood glucose in a patient with diabetes without altering the insulin level. according to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and a burning sensation in mouth with large amounts. Traditional Chinese medicine also insisted that an Overdose of cinnamon can be toxic and damage the liver(1).


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References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY. (PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ. (PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)

#Healthyfood #Asparagus May be Effective for the Treatment of Immune Diseases, Scientists Say

By Kyle J. Norton

Asparagus may have a profound and potential effect in reducing the risk of infection caused by microorganisms and preventing the overactive immune system to launch an attack on the body tissue, mistakenly, some scientists suggested.

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

In other words, the immunomodulatory activity involved in antimicrobial agents is to modulate the genes involved in immune reactions, or of the neurohormonal system which regulates immune functions and any toxic or immunotoxic effects such as allergic reactions or destruction of immune effectors, that may cause harm to the body or interfere with the body normal function.

Dr. Marie-Thérèse Labro in the study "Immunomodulatory Effects of Antimicrobial Agents. Part I"
with the assessment of the battle against infections, microorganisms are still a threat to mankind. said, "We have now entered the third era of anti-infective strategy, which intends to favor the interplay between active molecules and the immune system. The first part of this review focuses on the potential immunomodulating properties of anti-infective agents, beginning with antibacterial and antiviral agents".

Truly, regardless of hundreds of antibacterial medicine were produced by mankind, the major concerns remain about the emergence of resistant and multidrug-resistant pathogens,


The doctor continued, "(Particularly), the antiviral drug armamentarium is comprised of only a few dozen of compounds which are highly pathogen-specific, and resistance is also a concern".

Therefore, improving the immune function today still is the best method for reducing the risk of infection and autoimmune diseases

Asparagus is a flowering plant, belonging to the species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia.

The plant and food have been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

In the investigation of whether Asparagus racemosus Linn. (Fam. Liliaceae) an ethnopharmacologically acclaimed Ayurvedic medicinal plant processes the immunomodulatory effect against pathogens, researchers at the Centre for Phytochemistry and Pharmacology, by examining the action of an aqueous extract from the plant.

Observation of the immunoreactivity after injecting the extract into the human peripheral blood mononuclear cells (PBMC) isolated from whole blood on a ficoll-hypaque density gradient, showed a dose-dependent in stimulating the immune NK cell activity with a peak increase of 16.9±4.4% at 5.6 μg/ml.

Further differentiation suggested that ARP can achieve a higher stimulatory immune activity of 51.8±1.2% at 25 μg/ml.


These results suggested that A. racemosus processed an immune modulatory effect in potentiating the NK cell activity of the immune system.

Some researchers in the concerns of the current drug efficacies that suppress the immune function during the course of infection, conducted a study with an aim to find a natural compound with similar efficacy but no side effects.

The combination of Asparagus racemosus, an immunomodulatory drug, in combination with cisplatin against Leishmania donovani was used in the testing against parasite-infected BALB/c mice.

According to the final report, infection of A. racemosus at a dose of 650 mg/kg b.wt./day for 15 days, in combination with cisplatin at the dose of 5 mg/kg b.wt./day for 5 days, intraperitoneally exerted a significant effect in enhancing the clearance of parasites as determined by Giemsa-stained liver impression smears.

Moreover, Besides having better killing activity, the combination group achieved increased production of disease-resolving Th-1 response (IFN-gamma, IL-2) that has a function in killing intracellular parasites bacteria and viruses, heightened DTH (delayed-type hypersensitivity) response and augmented levels of antibody IgG2a.

The findings may suggest that A. racemosus in combination with cisplatin in L. donovani-infected BALB/c mice boosted and restored both cellular and humoral immunity.


Importantly, after taking into account co and confounders, Dr. Sachdeva H, the lead author added, "Moreover, A. racemosus in combination with cisplatin not only provided enhanced protective immune response but also resulted in remarkably improved kidney and liver function tests as manifested by normal levels of SGOT, SGPT, alkaline phosphatase, creatinine and urea in blood plasma with normal histological observations as compared to only cisplatin-treated L. donovani infected BALB/c mice".

Taken all together, Asparagus used alone or in combination with cisplatin in L. donovani may be considered primary Immunomodulatory therapy for the treatment of people with immune diseases.

However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of asparagus immunomodulatory possibilities.


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd. by Thakur M, Connellan P, Deseo MA, Morris C, Praznik W, Loeppert R, Dixit VK.(PubMed)
(2) Asparagus racemosus ameliorates cisplatin induced toxicities and augments its antileishmanial activity by immunomodulation in vivo. by Sachdeva H, Sehgal R, Kaur S.(PubMed)

#Healthyfood #Cranberry Inhibits the Risk of #Cancer in Vitro, Researchers Say

By Kyle J. Norton

Cancers are a class of chronic and medical conditions characterized by cells growing irregularly and disorderly in the tissue of a specific organ.
Most cases of cancer start in the cell on the surface of the inner lining of organ tissue caused by the alternation of the cell DNA.

At the early stage, due to the very small size of the tumor, patients may not experience any symptoms. However, as the cancer progresses, cancer cells may penetrate into deeper layers, before colonizing entire organs. At this stage, the primary cancer cells can travel a distance away from the original site to infect other healthy tissue and organ via fluid and blood circulation.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, based on the 2013–2015 data.

In 2017, about 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer. Cancer in the same year also causes the death 1,790 of children and adolescent Americans.

As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.

There are many prevalent factors associated with cancer onset, including an increase in age, excessive alcohol consumption, exposure to chemical toxins and sunlight, and infectious pathogens.

The most common factors that cause the rise of cancer, including colorectal cancer in the Western world according to Dr. Omran S, the led author in the study of "Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals" are dietary patterns, sedentary lifestyle, and other practices.

In CRC risk, the doctor continued, aging with the mean age of 57.0 ± 8.56 years, male gender with less than secondary school formal education.

And, the commonest risk factors for CRC among the participants were overweight or obesity (76.1 %), lack of exercise (71.6 %), limited consumption of vegetables (70.8 %), smoking (60.6 %), over-consumption of red meat (56.3 %), and diabetes mellitus (24.1 %)".

However, most people with some of the aforementioned risk factors have never developed cancer.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound that processes chemopreventive activity, researchers assessed the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines.

According to the results of AW13516 (poorly to moderately differentiated squamous cell carcinoma of the tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assays, the CHX efficacy of 80.15% & 95.7% of growth inhibition against AW13516 & KB cell line respectively.

* Administration of CE (80µg/ml) showed no anti-cancer properties against the AW13516 cell line.

*However, CE inhibited 70.6% growth against the KB cell line.

Furthermore, both CHX and CE were less potent than the positive control drug Adriamycin, at the values of GI50, TGI, and LC50.

Based on the findings, researchers said, "CHX exhibited better anti-cancer properties than CE for both the oral cancer cell lines".

In other words, CE exerted anti-cancer activity depending on the types of primary cancer cells.

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cancer, depending on the types of primary cancer cells, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anticancer activity of chlorhexidine and cranberry extract: an in-vitro study by Khairnar MR1, Wadgave U1, Jadhav H2, Naik R. (PubMed)
(2) Cranberry and its phytochemicals: a review of in vitro anticancer studies by Neto CC. (PubMed)

#Healthyfood #CarrotJuices In Reducing the Risk #ColonCancer, Researchers Say

By Kyle J. Norton

Carrots may have a profound and positive effect on reduced risk, progression and treatment of colon cancer, some scientists suggested.

Colon cancer is a chronic condition characterized by irregular cell growth in the colon tissue. At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue and organs.

As of today, researchers do not know what causes colon cancer. However, certain risk factors, such as genetic mutations that induce healthy DNA change are associated to increase the risk of cancer.

Some researchers suggested that an unhealthy diet and lifestyle such as an American diet with a high intake of red meat, low intake of fiber, low intake of calcium, cigarette smoking,.... and obesity are the prevalent risk factors of colon cancer(4).

And increase consumption of a wide variety of fruit and vegetable, particularly, dark-green leafy, cruciferous, deep-yellow on tones, and fiber are convincing preventive factors(5).

Dr. Corrêa Lima MP, the lead author at the Mato Grosso Federal University said, "Lifestyle modification including proper diets such as the ones rich in vegetables and poor in red meat and fat, regular physical activity and maintaining an appropriate body weight and avoiding the use of tobacco and alcohol may lead to reduce colorectal cancer risk"(5).

Patients with early-stage colon cancer may experience gastrointestinal symptoms of changes in bowel habits, and constipation. diarrhea or alternating diarrhea and constipation. Some patients may also develop symptoms of from rectal bleeding or blood in their stool, abdominal bloating,.... and cramps or discomfort.

Truly, some chronic conditions and medicine used for treatments also were found to increase the risk of colon cancer, including diabetes, acromegaly, a growth hormone disorder,,,, and radiation treatment for other cancers.

In the US, colorectal cancer is the third most common cancer diagnosed in both men and women.
According to the statistic of the American Cancer Society, in 2018, approximately, 97,220 new cases of colon cancer. and 43,030 new cases of rectal cancer. are diagnosed in the US. Colorectal cancer also causes the death of 50,630 in 2018(6).

Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

According to the study to determine the anticancer activity of the pentane fraction (F1) and the 1:1 pentane:diethyl ether fraction (F2) isolated from Daucus Carota oil extract (DCOE) against human colon adenocarcinoma cell lines (HT-29 and Caco-2), application of various concentration of both extracts exerted significant inhibitory effect against the proliferation and induced apoptosis through numbers of factors.


The observation by Western blot revealed that the activity of F1 and F2 constrict the expansion of the tumor through activation of caspase-3, the key protein facilitators with function to execute apoptosis or program cell death and PARP cleavage, with function in stimulated various pathological cell death processes.

Further analysis also suggested that F1 and F2 inhibited the cell death processes through increased levels of Bax expression in initiated pro-apoptosis involved in a wide variety of cellular activities and p53 in the regulated cell cycle as a tumor suppressor.

Together, both injections also decreased levels of Bcl-2 with function in inhibited tumor cells apoptosis.


Moreover, treatment of HT-29 cells with either fraction markedly also induced cell adhesion, cell cycle progression, cell migration, and cell apoptosis through decreased levels of both phosphorylated Erk and Akt.

Activation of oncogenic signaling proteins AKT and ERK by phosphorylation has an established role in the development of certain types of cancer(7).

Additionally, in mice model, β-2-himachalen-6-ol (HC) isolated from the Daucus carota oil extract st the concentration of 1, 5, 10, and 25 μg/ml, were also found to inhibit number of cancers, including colon cell progression.

In SW1116 colon cancer cell lines, injection of β-2-himachalen-6-ol (HC) demonstrated significant inhibitory activity in a dose-dependent in decreased cell survival with an IC50 of 18 and 14.5 μg/ml after 24 and 48 h respectively.
According to the Flow cytometry analysis, at a concentration of 10 μg/ml, HC increased the number of tumor cells undergoing necrosis by 18.05% and 58.01% and late apoptosis by 15.66% and 30.47%, respectively.

These results suggested that β-2-himachalen-6-ol (HC) induced cancer cell apoptosis and cancer growth restriction, linearly in doses dependent manner.

Additional differentiation also suggested the application exerted anti colon cancers cell line effect through similar proteins and pathways as mentioned in the first study.

Most importantly, β-2-himachalen-6-ol (HC) inhibited colon cancer cell line through cytotoxicity in the cell cycle arrested without causing harm to the nearby healthy cells.

The above illustration was also supported by the investigation of beta-carotene and lycopene, a bioactive phytochemicals found in carrots in a modify luminal process relevant to colon carcinogenesis conducted by the Technical University of Munich.

According to the randomized cross-over trial of twenty-two, healthy young men on a low-carotenoid diet consumed 330 ml tomato or carrot juice per d for 2 weeks, consumption of carrot juice led to a marked increase of beta-carotene and alpha-carotene in fecal water with high dose-dependent cytotoxic and antiproliferative effects on colon adenocarcinoma cells (HT29).

Taken together, carrots and their bioactive compounds may be considered a functional food in ameliorating risk and increasing the efficacy of conventional medicine for the treatment of colon cancer.

However, further data collection on large example size and multi centers studies performed with human consumption of the carrot and its bioactive phytochemicals, during the course of the disease will be necessary to complete the picture of their anti-colon cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shebaby WN1, Bodman-Smith KB1, Mansour A2, Mroueh M3, Taleb RI4, El-Sibai M4, Daher CF4. (PubMed)
(2) Effects of carrot and tomato juice consumption on fecal markers relevant to colon carcinogenesis in humans by Schnäbele K1, Briviba K, Bub A, Roser S, Pool-Zobel BL, Rechkemmer G.(PubMed)

(3) Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways by Daaboul HE1, Daher CF2, Bodman-Smith K1, Taleb RI2, Shebaby WN2, Boulos J2, Dagher C3, Mroueh MA4, El-Sibai M5.(PubMed)
(4) Lifestyle Factors and Their Combined Impact on the Risk of Colorectal Polyps by Zhenming Fu, Martha J. Shrubsole, Walter E. Smalley, Huiyun Wu, Zhi Chen, Yu Shyr, Reid M. Ness, and Wei Zheng(PMC)
(5) Colorectal cancer: lifestyle and dietary factors by Corrêa Lima MP1, Gomes-da-Silva MH(PubMed)
(6) Key Statistics for Colorectal Cancer by American Cancer Society
(7) ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing by Crosbie PA1, Crosbie EJ2, Aspinall-O'Dea M3, Walker M3, Harrison R4, Pernemalm M5, Shah R6, Joseph L7, Booton R8, Pierce A3, Whetton AD(PubMed)

#Healthyfood #Ginger Inhibits the Expression of #ProinflammatoryCytokines Against the Onset of Nonalcoholic Hepatic Steatosis (#FattyLiver), According to Researchers

By Kyle J. Norton

Ginger may have a profound effect in reducing the risk and treatment of hepatic steatosis, the early stage of liver disease, some scientists suggested.
Hepatic steatosis or fatty liver is a condition that caused excess fat to accumulate in the liver.

At the early stage of hepatic steatosis, the patient may not experience any symptoms. However, at the condition of progress, the condition induces liver inflammation, which may progress to scarring and irreversible damage. Patients at this stage can have symptoms of abdominal swelling, enlarged blood vessels in the skin and spleen accompanied by jaundice.

The most common risk factors are the increase in age, (older than 45 years of age). overweight and obesity and ethnicity.

However, some researchers suggested the coincidence of widespread obesity and the onset of hepatic steatosis might indicate a close correlation between these 2 conditions.

Dr. Festi D, the lead author in the finding the relation between obesity and hepatic steatosis causes a wide spectrum of liver damage as simple steatosis may progress to advanced fibrosis and to cryptogenic cirrhosis through steatohepatitis launched an investigation to examine the risk of hepatic steatosis in obese patients.
After taking into account co and confounders wrote, "Obesity is the most significant single risk factor for the development of fatty liver, both in children and in adults; obesity is also predictive of the presence of fibrosis, potentially progressing to advanced liver disease".

The risk of a fatty liver may be associated with insulin resistance in obese patients that play a central role in the accumulation of triglycerides within the hepatocytes and in the initiation of the inflammatory cascade.

Although conventional treatment with insulin-sensitizing agents, anti-oxidants or cytoprotective drugs may be useful, however, they are no randomized clinical trials to support the efficacy.

As of today, there is no direct treatment of hepatic steatosis but relieves the symptoms.

Some researchers suggested modifications in lifestyle (e.g. diet and exercise) to reduce obesity remain the mainstay of prevention and treatment of a disease,


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In finding a natural whole food that may have a potent to prevent and treat nonalcoholic fatty liver, researchers at the Tajen University, Yanpu Township investigate the effects of [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanoate) in experimental models of the non-alcoholic fatty liver.

[6]-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells.

In the study of male golden hamsters were dosed orally with [6]-gingerol (25, 50 or 100 mg/kg/day) once daily for 8 weeks after being fed a high-fat diet (HFD) for 2 weeks, injection of [6]-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed plasma markers of metabolic syndrome in HFD-fed hamsters.

[6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.

These results indicated a significant effect of [6]-Gingerol in the attenuation of HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.

Additionally, in the concern of widespread Nonalcoholic fatty liver disease (NAFLD) may reach epidemic proportions, Dr. Sahebkar A. launched a study to evaluate the ginger effect at the "two-stage hypothesis" proposed for the pathophysiology of NAFLD, insulin resistance, oxidative stress and pro-inflammatory cytokines among the key promoters of the disease.

The application of ginger prevents NAFLD or blunts its progression via several mechanisms, such as sensitizing insulin effects, and down-regulates pro-inflammatory cytokines.

Ginger promoted considerable antioxidant effects and antidyslipidemic properties and reduced hepatic triglyceride content which can prevent steatosis.

All these mechanisms suggested that ginger possesses interesting potential for serving as a natural supplement for the prevention and treatment of NAFLD.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(2) Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease by Sahebkar A. (PubMed)
(3) Hepatic steatosis in obese patients: clinical aspects and prognostic significance by Festi D1, Colecchia A, Sacco T, Bondi M, Roda E, Marchesini G.(PubMed)