By Kyle J. Norton
Beet may have a potential effect as antioxidants in reduced free radical and oxidative stress expression through its chemical constituents, some scientists suggested
Antioxidants are a set of substances with inhibited oxidative function
Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the joint study led by the Istanbul Technical University, fresh red beetroot and beetroots products contain several major antioxidants with efficacy different, depending on total antioxidant capacities (TAC)(total phenolic (TP) and total flavonoid (TF) contents and individual).
In Lactobacillus paracasei 0920 (FBJ) on carcinogen induction of aberrant crypt foci (ACF), the abnormal tube-like glands in the lining of the colon and rectum in rat colon by 2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) administrated intragastrically at a dose of 10 μg/day, every day of the experiment, rats fed with beetroot juice showed a significant improvement of cytotoxic and genotoxic effects through increased the antioxidant status of serum from 40% to 66% depending on the fraction.
In other words, oxidative stress-induced production of toxins and toxic chemical agents which may alternate DNA transcript were inhibited by phytochemicals in beet juice.
2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) is a toxic chemical formed in condensation of creatinine found in muscle meats, with amino acids in high temperature,
Interestingly, the formation of pro-oxidative stress found in the blood of colorectal carcinoma patients. was associated with decreased concentration of antioxidant status together with a lower amount of uric acid in the expression of antioxidants which was found to have a potential effect
in the treatment of diseases associated with oxidative stress.
Furthermore, levels of oxidative stress are also found in the measurement of serum antioxidant status and the level of malondialdehyde, a marker of oxidative stress in the rat's kidneys and liver.
Additionally, in a male Wistar rat model of oxidative stress induced by N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl(4)), the group fed with beetroot juice per os, 8 mL/kg/day for 28 days, and a single i.p. the dose of the xenobiotics: 150 mg/kg NDEA or 2 mL/kg CCl(4) and xenobiotics the only group, the treatment group showed a partial recovery in the activity of glutathione peroxidase and glutathione reductase, by 35% and 66%, respectively.
Glutathione peroxidase (GPx) with peroxidase activity is an antioxidant with a function to protect the organism from oxidative damage.
The activity of glutathione reductase is a cellular antioxidant with a function to protect the organism against xenobiotics.
Particularly, the levels of Superoxide dismutase activity against the oxidative stress-induced formation of inflammation also increased by 3-fold compared to the non-juice treatment group.
Importantly, the treatment group also showed significant inhibition of oxidative stress in protected DNA damage caused by N-nitroso diethylamine (NDEA) and carbon tetrachloride (CCl(4)) by 20%.
These findings showed a remarkable efficacy of beet juice and products in ameliorating free radicals and pro-inflammatory expression through elevated antioxidant status which warrant a human trial for validity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Home-Processed Red Beetroot (Beta vulgaris L.) Products: Changes in Antioxidant Properties and Bioaccessibility by Guldiken B1, Toydemir G2, Nur Memis K3, Okur S4, Boyacioglu D5, Capanoglu E6.(PubMed)
(2) Protective effect of lactofermented red beetroot juice against aberrant crypt foci formation, genotoxicity of fecal water and oxidative stress induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in rats modelm by Klewicka E1, Nowak A, Zduńczyk Z, Juśkiewicz J, Cukrowska B.(PubMed)
Sunday, 4 June 2023
#BlackBean Extracts In Reducing the Risk of Hyperglycemia, Researchers Show
By Kyle J. Norton
Hyperglycemia is a condition of abnormally high blood glucose present in the bloodstream.
Black beans, small roughly ovoid legumes with glossy black shells, genus Phaseolus, and belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was the first domesticated growth in South America.
Black or common beans with abundant fiber may be considered as functional foods in reduced risk of hyperglycemia, the early onset of diabetes, a renowned institute postulated.
In high-fat diet-induced glucose-intolerant obese C57BL/6J mice, black adzuki bean (BAB) extract injection showed an improved function of pancreatic β cells in inhibiting tolerance of the high glucose-induced glucotoxicity at a concentration of 0.2 mg/mL.
The dietary supplementation BAB extract also expressed significantly (P < .05) improved hyperglycemia and homeostasis model, using an insulin resistance index (HOMA-IR).
Furthermore, mice fed with the extract also stimulated gene expression in regulated glucose metabolism and insulin response.
Dr. Kim M, the lead researcher said, "BAB extract ameliorates hyperglycemia and glucose intolerance, and lowers HOMA-IR (assessment) by regulating insulin secretion and response, and by maintaining the integrity of pancreatic β cells exposed to hyperglycemic conditions".
Additionally, in the investigated possible protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE), and a combination of the two (PPE + BBPE) on streptozotocin-induced DM mice, researchers at the Xuzhou Medical College, indicated that black bean fed mice showed different degrees, in decreased blood glucose, increased insulin secretion, pancreas weight index, and antioxidative activity.
Dr. Wang JY, the lead author said, "PPE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress-induced pancreatic damage".
The results of these experiments not only displayed the positive effects of black beans in reduced hyperglycemia risk regardless of types of preparation but also addressed the important issue of the contribution of higher outcomes in risk control.
Promisingly, in the compared glycemic response of bean and rice in traditional meals and rice alone in adults with type 2 diabetes of 17 men and women, group injection of traditional meals showed lower postprandial net glucose values in contrast to the rice control at 90, 120 and 150 minutes.
Collectively, the black bean may be used as a functional food in ameliorating the risk and treatment of hyperglycemia, thus reducing the risk of early onset of diabetes.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet by Kim M1, Kim DK2, Cha YS1.(PubMed)
(2) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)
(3) Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study by Thompson SV1, Winham DM, Hutchins AM.(PubMed)
Hyperglycemia is a condition of abnormally high blood glucose present in the bloodstream.
Black beans, small roughly ovoid legumes with glossy black shells, genus Phaseolus, and belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was the first domesticated growth in South America.
Black or common beans with abundant fiber may be considered as functional foods in reduced risk of hyperglycemia, the early onset of diabetes, a renowned institute postulated.
In high-fat diet-induced glucose-intolerant obese C57BL/6J mice, black adzuki bean (BAB) extract injection showed an improved function of pancreatic β cells in inhibiting tolerance of the high glucose-induced glucotoxicity at a concentration of 0.2 mg/mL.
The dietary supplementation BAB extract also expressed significantly (P < .05) improved hyperglycemia and homeostasis model, using an insulin resistance index (HOMA-IR).
Furthermore, mice fed with the extract also stimulated gene expression in regulated glucose metabolism and insulin response.
Dr. Kim M, the lead researcher said, "BAB extract ameliorates hyperglycemia and glucose intolerance, and lowers HOMA-IR (assessment) by regulating insulin secretion and response, and by maintaining the integrity of pancreatic β cells exposed to hyperglycemic conditions".
Additionally, in the investigated possible protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE), and a combination of the two (PPE + BBPE) on streptozotocin-induced DM mice, researchers at the Xuzhou Medical College, indicated that black bean fed mice showed different degrees, in decreased blood glucose, increased insulin secretion, pancreas weight index, and antioxidative activity.
Dr. Wang JY, the lead author said, "PPE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress-induced pancreatic damage".
The results of these experiments not only displayed the positive effects of black beans in reduced hyperglycemia risk regardless of types of preparation but also addressed the important issue of the contribution of higher outcomes in risk control.
Promisingly, in the compared glycemic response of bean and rice in traditional meals and rice alone in adults with type 2 diabetes of 17 men and women, group injection of traditional meals showed lower postprandial net glucose values in contrast to the rice control at 90, 120 and 150 minutes.
Collectively, the black bean may be used as a functional food in ameliorating the risk and treatment of hyperglycemia, thus reducing the risk of early onset of diabetes.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet by Kim M1, Kim DK2, Cha YS1.(PubMed)
(2) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)
(3) Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study by Thompson SV1, Winham DM, Hutchins AM.(PubMed)
#Herbal #AloeVera Inhibits the Expression of Bacterial Count, According to Clinical Trials
By Kyle J. Norton
A recent study by the renowned institute suggested that Aloe Vera or Aloe Vera supplements may reduce the risk of microbial infection and infectious diseases.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wounds, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
In a total of Sixty students in the age group, 6-12 years selected from an orphanage center, divided into four groups study, oral administration of the Aloe Vera group showed a decrease of the bacterial count by 80.94%.
Dr. Bhati N, the lead author said, "Herbal dentifrices containing A. Vera... can be safely recommended as an alternative to fluoridated dentifrices in terms of antimicrobial efficacy".
In Streptococcus mutant strains, Aloe vera brushing showed a reduced bacteria contamination of Streptococcus mutant strains, without differentiation from the other chemical agents used.
In fact, Aloe vera in the study against pathogenic such as Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Salmonella Typhimurium, Proteus vulgaris, Klebsiella pneumoniae, Escherichia coli, Streptococcus pyogenes and Candida albicans displayed a significantly antimicrobial inhibition rate zones ranging from 6.0 ± 0.57 to 16.6 ± 0.57 mm as the result of the expression of bioactive compounds with high 2,2-diphenyl-1-picrylhydrazyl (DPPH, stable free-radical molecules isolated from the herb), composed of scavenging properties.
Taking together, oral administration of Aloe Vera is found to associate with a reduced risk of microbial infection and infectious diseases, but large amounts of intake should only be prescribed by related field specialists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of antimicrobial efficacy of Aloe vera and Meswak containing dentifrices with fluoridated dentifrice: An in vivo study by Bhati N1, Jaidka S1, Somani R1(PubMed)
(2) Antimicrobial capacity of Aloe vera and propolis dentifrice against Streptococcus mutans strains in toothbrushes: an in vitro study by Bertolini PF1, Biondi Filho O, Pomilio A, Pinheiro SL, Carvalho MS.(PubMed)
(3) Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera by Akinsanya MA1, Goh JK2, Lim SP2, Ting AS3.(PubMed)
A recent study by the renowned institute suggested that Aloe Vera or Aloe Vera supplements may reduce the risk of microbial infection and infectious diseases.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wounds, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
In a total of Sixty students in the age group, 6-12 years selected from an orphanage center, divided into four groups study, oral administration of the Aloe Vera group showed a decrease of the bacterial count by 80.94%.
Dr. Bhati N, the lead author said, "Herbal dentifrices containing A. Vera... can be safely recommended as an alternative to fluoridated dentifrices in terms of antimicrobial efficacy".
In Streptococcus mutant strains, Aloe vera brushing showed a reduced bacteria contamination of Streptococcus mutant strains, without differentiation from the other chemical agents used.
In fact, Aloe vera in the study against pathogenic such as Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Salmonella Typhimurium, Proteus vulgaris, Klebsiella pneumoniae, Escherichia coli, Streptococcus pyogenes and Candida albicans displayed a significantly antimicrobial inhibition rate zones ranging from 6.0 ± 0.57 to 16.6 ± 0.57 mm as the result of the expression of bioactive compounds with high 2,2-diphenyl-1-picrylhydrazyl (DPPH, stable free-radical molecules isolated from the herb), composed of scavenging properties.
Taking together, oral administration of Aloe Vera is found to associate with a reduced risk of microbial infection and infectious diseases, but large amounts of intake should only be prescribed by related field specialists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of antimicrobial efficacy of Aloe vera and Meswak containing dentifrices with fluoridated dentifrice: An in vivo study by Bhati N1, Jaidka S1, Somani R1(PubMed)
(2) Antimicrobial capacity of Aloe vera and propolis dentifrice against Streptococcus mutans strains in toothbrushes: an in vitro study by Bertolini PF1, Biondi Filho O, Pomilio A, Pinheiro SL, Carvalho MS.(PubMed)
(3) Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera by Akinsanya MA1, Goh JK2, Lim SP2, Ting AS3.(PubMed)
#Healthyfood #CruciferousVegetables Inhibits the #OxidativeStress Against the Onset of Cancers, Scientists Show
By Kyle J. Norton
Cruciferous vegetables, rich in phytochemicals may be considered as the functional food for the prevention of cancers caused by chemical carcinogens some studies suggested.
Chemical carcinogens, types of chemical toxins, can induce cellular and chromosome change and DNA damage, causing the mutation of healthy cells, the initial stage of cancer development.
According to the National Toxicology Program 14th Report on Carcinogens “Known to be human carcinogens” provided by the American Cancer Society, there are many different types of chemical carcinogens, including
* Lifestyle factors (nutrition, tobacco use, physical activity, etc.)
* Naturally occurring exposures (ultraviolet light, radon gas, infectious agents, etc.)
* Medical treatments (radiation and medicines including chemotherapy, hormone drugs, drugs that suppress the immune system, etc.)
* Workplace Exposures
* Household exposures
* Pollution
Cancers are a class of medical diseases characterized by cells that multiply disorderly and uncontrollably.
At the advanced stage, most cancers can travel a distance away from the site of origin to infect other healthy cells and tissue via lymph and blood.
According to the Universidade Federal de Ouro Preto, sulforaphane (SFN), the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetables expressed chemopreventive properties involved detoxification processes of chemical carcinogens.
Dr. de Figueiredo SM, the lead author said, " In a dose-dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells, and presents an antiinflammatory effect acting during the initial of uncontrolled cell proliferation."
The chemoprotective activity of the cruciferous vegetable was attributed to the significant expression of the antioxidants in cell cycle arrest and apoptosis of cancer cells.
Furthermore, its phytochemicals also can act as the post-initiation stages of carcinogenesis, 'suppressing' agents involving the ability to modulate the Nrf2 which is a protein with the unique function of regulating the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
In fact, besides using as a chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN), the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin inducing of cancers.
Moreover, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, the unique function of inhibiting oxidate stress, and free radicals produced by lipid peroxidation in cells.
Additionally, in tobacco smoke carcinogens-induced chemical tumors, cruciferous vegetable consumption has been shown to be inversely associated with the development of cancer.
In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetables, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with the function of metabolized potentially toxic compounds.
Taking together, the intake of cruciferous vegetables has a potential health benefit against environmental toxins that initiates the early onset of cancers. But due to the small size of the sample, further studies are necessary to address the veggie's anti cancers possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)
Cruciferous vegetables, rich in phytochemicals may be considered as the functional food for the prevention of cancers caused by chemical carcinogens some studies suggested.
Chemical carcinogens, types of chemical toxins, can induce cellular and chromosome change and DNA damage, causing the mutation of healthy cells, the initial stage of cancer development.
According to the National Toxicology Program 14th Report on Carcinogens “Known to be human carcinogens” provided by the American Cancer Society, there are many different types of chemical carcinogens, including
* Lifestyle factors (nutrition, tobacco use, physical activity, etc.)
* Naturally occurring exposures (ultraviolet light, radon gas, infectious agents, etc.)
* Medical treatments (radiation and medicines including chemotherapy, hormone drugs, drugs that suppress the immune system, etc.)
* Workplace Exposures
* Household exposures
* Pollution
Cancers are a class of medical diseases characterized by cells that multiply disorderly and uncontrollably.
At the advanced stage, most cancers can travel a distance away from the site of origin to infect other healthy cells and tissue via lymph and blood.
According to the Universidade Federal de Ouro Preto, sulforaphane (SFN), the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetables expressed chemopreventive properties involved detoxification processes of chemical carcinogens.
Dr. de Figueiredo SM, the lead author said, " In a dose-dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells, and presents an antiinflammatory effect acting during the initial of uncontrolled cell proliferation."
The chemoprotective activity of the cruciferous vegetable was attributed to the significant expression of the antioxidants in cell cycle arrest and apoptosis of cancer cells.
Furthermore, its phytochemicals also can act as the post-initiation stages of carcinogenesis, 'suppressing' agents involving the ability to modulate the Nrf2 which is a protein with the unique function of regulating the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
In fact, besides using as a chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN), the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin inducing of cancers.
Moreover, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, the unique function of inhibiting oxidate stress, and free radicals produced by lipid peroxidation in cells.
Additionally, in tobacco smoke carcinogens-induced chemical tumors, cruciferous vegetable consumption has been shown to be inversely associated with the development of cancer.
In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetables, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with the function of metabolized potentially toxic compounds.
Taking together, the intake of cruciferous vegetables has a potential health benefit against environmental toxins that initiates the early onset of cancers. But due to the small size of the sample, further studies are necessary to address the veggie's anti cancers possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)
#Antioxidant #Betacyanins Exhibit Free Radical Scavenger Activities Against the Onset of #OxidativeStress, Researchers Reveal
By Kyle J. Norton
Oxidative stress is a medical condition caused the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.
In fact, free radicals exist everywhere including the air we breathe, the thing we eat, and the environment we contact, particularly, cell metabolism in the body.
Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.
Other diseases such as hypertension, dyslipidemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity are also found in patients with oxidative stress.
In spite of free radicals' harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.
Free radicals are unstable atoms with an unpair of electrons on the out ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules which inhibit free radicals.
Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.
Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, for people with weakened immune systems intake of dietary antioxidants or antioxidant supplements may be necessary.
Dr. Pignatelli P. the lead scientist in the investigation of the relationship between oxidative stress and antioxidants in CVD wrote, " 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress".
In other words, by understanding the interaction of free radicals and antioxidant, diseases associated with oxidative stress may be preventable.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllocactin and betanidin.
According to the test from the peroxyl radical generating system, betacyanins exerted a significant peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).
In chemical analysis, betanidin, betanin, and phyllotactic demonstrated antioxidant capacity at the order of 10.70, 3.31, and 2.83 mol-TEA/mol-compound respectively.
The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin and betanidin.was 24.48, 17.51 and 6.81, respectively.
In other words, betanidin was the strongest antioxidant that exerted radical scavenging activity compared to those betanin, and phyllocactin.
Furthermore, the expression of free radical NO was reduced by the administration of betacyanin in the low concentration range of 2.5-20 μM.
Based on the results, researchers said, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".
And, "This study demonstrated that the betacyanins will be useful as natural pigments to provide defense against oxidative stress".
Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Oxidative stress and cardiovascular disease: new insights by Pignatelli P1, Menichelli D, Pastori D, Violi F. (PubMed)
Oxidative stress is a medical condition caused the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.
In fact, free radicals exist everywhere including the air we breathe, the thing we eat, and the environment we contact, particularly, cell metabolism in the body.
Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.
Other diseases such as hypertension, dyslipidemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity are also found in patients with oxidative stress.
In spite of free radicals' harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.
Free radicals are unstable atoms with an unpair of electrons on the out ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules which inhibit free radicals.
Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.
Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, for people with weakened immune systems intake of dietary antioxidants or antioxidant supplements may be necessary.
Dr. Pignatelli P. the lead scientist in the investigation of the relationship between oxidative stress and antioxidants in CVD wrote, " 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress".
In other words, by understanding the interaction of free radicals and antioxidant, diseases associated with oxidative stress may be preventable.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllocactin and betanidin.
According to the test from the peroxyl radical generating system, betacyanins exerted a significant peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).
In chemical analysis, betanidin, betanin, and phyllotactic demonstrated antioxidant capacity at the order of 10.70, 3.31, and 2.83 mol-TEA/mol-compound respectively.
The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin and betanidin.was 24.48, 17.51 and 6.81, respectively.
In other words, betanidin was the strongest antioxidant that exerted radical scavenging activity compared to those betanin, and phyllocactin.
Furthermore, the expression of free radical NO was reduced by the administration of betacyanin in the low concentration range of 2.5-20 μM.
Based on the results, researchers said, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".
And, "This study demonstrated that the betacyanins will be useful as natural pigments to provide defense against oxidative stress".
Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Oxidative stress and cardiovascular disease: new insights by Pignatelli P1, Menichelli D, Pastori D, Violi F. (PubMed)
#Antioxidant #Carotenoids Reduce Risk of #LungCancer, According to Clinical Trials
By Kyle J. Norton
The lung is one of the vital organs in humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a chronic medical condition characterized by abnormal growth of the cells in the lung's tissue.
The most common form of primary lung cancer is derived from epithelial cells.
The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease, and excessive drinking are some prevalent factors associated with lung cancer developing.
According to the statistics provided by the American cancer society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 women in the same year.
Lung cancer can be classified into 2 major types
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably. The most common types of Non-small cell lung cancer lung cancers include
**Squamous-cell carcinoma often is found in an outer area of the lung.
** Large-cell carcinoma is found in the center of the lung by an air tube.
** Adenocarcinoma is found in any part of the lung.
* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage. The most common types of small cell lung cancer include
* Small cell carcinoma is small, round, and resembles oats.
*Mixed small cell/large cell carcinoma is found in combining components of small cell lung carcinoma with large cell lung carcinoma.
*Combined small cell carcinoma is found in combining a component of small cell lung carcinoma with components of non-small cell lung carcinoma.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
In finding a potential compound for the treatment of lung cancer, researchers compared the dietary intake and serum levels of some selected carotenoids of lung cancer patients with healthy subjects.
The case-control study included 35 lung cancer patients and 33 healthy people with a daily intake of nutrients estimated by using a semiquantitative food frequency questionnaire and a 3-day 24-h food recall questionnaire.
According to the tested analysis,
* The beta-carotene and lycopene intake of the case subjects was 96% and 195% higher in the lung participants compared to those of the control.
* Daily intake of fruits and vegetables in the cancer group was higher compared to the control group.
However, the serum concentration of beta-carotene and lycopene were 118% and 60% higher in the control group compared to the lung cancer group.
These results suggested that there must be some unknown mechanisms associated with the reduced levels of beta-carotene and lycopene in the blood of lung cancer patients.
In other words, the intake of beta-carotene and lycopene daily reduces the risk of lung cancer in healthy individuals.
Dr. Asbaghi S, the lead scientist after taking other factors such as age, gender, smoking habits, weight, body mass index, mean daily energy intake and mean daily fat intake into account wrote, "Despite a higher daily dietary intake of beta-carotene and lycopene by lung cancer patients, serum beta-carotene and lycopene concentrations were significantly lower than the group without cancer".
Taken altogether, carotenoids processed abundantly beta-carotene and lycopene may be considered a remedy for the prevention of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Intake and Serum Level of Carotenoids in Lung Cancer Patients: A Case-Control Study by Asbaghi S1, Saedisomeolia A, Hosseini M, Honarvar NM, Khosravi A, Azargashb E. (PubMed)
(2) Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF-AICR systematic review of published prospective studies by Abar L1, Vieira AR1, Aune D1,2, Stevens C1, Vingeliene S1, Navarro Rosenblatt DA1, Chan D1, Greenwood DC3, Norat T. (PubMed)
(3) Lung Cancer by Kyle J. Norton
The lung is one of the vital organs in humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a chronic medical condition characterized by abnormal growth of the cells in the lung's tissue.
The most common form of primary lung cancer is derived from epithelial cells.
The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease, and excessive drinking are some prevalent factors associated with lung cancer developing.
According to the statistics provided by the American cancer society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 women in the same year.
Lung cancer can be classified into 2 major types
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably. The most common types of Non-small cell lung cancer lung cancers include
**Squamous-cell carcinoma often is found in an outer area of the lung.
** Large-cell carcinoma is found in the center of the lung by an air tube.
** Adenocarcinoma is found in any part of the lung.
* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage. The most common types of small cell lung cancer include
* Small cell carcinoma is small, round, and resembles oats.
*Mixed small cell/large cell carcinoma is found in combining components of small cell lung carcinoma with large cell lung carcinoma.
*Combined small cell carcinoma is found in combining a component of small cell lung carcinoma with components of non-small cell lung carcinoma.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
In finding a potential compound for the treatment of lung cancer, researchers compared the dietary intake and serum levels of some selected carotenoids of lung cancer patients with healthy subjects.
The case-control study included 35 lung cancer patients and 33 healthy people with a daily intake of nutrients estimated by using a semiquantitative food frequency questionnaire and a 3-day 24-h food recall questionnaire.
According to the tested analysis,
* The beta-carotene and lycopene intake of the case subjects was 96% and 195% higher in the lung participants compared to those of the control.
* Daily intake of fruits and vegetables in the cancer group was higher compared to the control group.
However, the serum concentration of beta-carotene and lycopene were 118% and 60% higher in the control group compared to the lung cancer group.
These results suggested that there must be some unknown mechanisms associated with the reduced levels of beta-carotene and lycopene in the blood of lung cancer patients.
In other words, the intake of beta-carotene and lycopene daily reduces the risk of lung cancer in healthy individuals.
Dr. Asbaghi S, the lead scientist after taking other factors such as age, gender, smoking habits, weight, body mass index, mean daily energy intake and mean daily fat intake into account wrote, "Despite a higher daily dietary intake of beta-carotene and lycopene by lung cancer patients, serum beta-carotene and lycopene concentrations were significantly lower than the group without cancer".
Taken altogether, carotenoids processed abundantly beta-carotene and lycopene may be considered a remedy for the prevention of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Intake and Serum Level of Carotenoids in Lung Cancer Patients: A Case-Control Study by Asbaghi S1, Saedisomeolia A, Hosseini M, Honarvar NM, Khosravi A, Azargashb E. (PubMed)
(2) Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF-AICR systematic review of published prospective studies by Abar L1, Vieira AR1, Aune D1,2, Stevens C1, Vingeliene S1, Navarro Rosenblatt DA1, Chan D1, Greenwood DC3, Norat T. (PubMed)
(3) Lung Cancer by Kyle J. Norton
#Phytochemical #Betanin Protects the #HeartFunctiong by Normaling High Blood Pressure, According to Studies
By Kyle J. Norton
Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart's function in pumping blood to the body.
Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and type 2 diabetes
Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.
Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, shortness of breath, early signs of heart disease, and stroke.
According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.
Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taken into account.
Sadly, only half of the people with high blood pressure in the US are under control.
There are 2 types of hypertension, including primary hypertension which takes years to develop, and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.
Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.
Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".
And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".
The results strongly suggested the high-fat diet-induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.
The study included animals divided into six main groups with each group containing 5 animals.
* Group I received the vehicle,
* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,
* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,
* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,
* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and
* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.
At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to the Dexamethasone group.
According to the tested assays, Dexamethasone treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), and vascular reactivity changes to Catecholamine, compared to the control group.
Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone-administered rats significantly (p<0.05) demonstrated a significant reversal of such change.
Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".
In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)
Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart's function in pumping blood to the body.
Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and type 2 diabetes
Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.
Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, shortness of breath, early signs of heart disease, and stroke.
According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.
Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taken into account.
Sadly, only half of the people with high blood pressure in the US are under control.
There are 2 types of hypertension, including primary hypertension which takes years to develop, and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.
Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.
Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".
And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".
The results strongly suggested the high-fat diet-induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.
The study included animals divided into six main groups with each group containing 5 animals.
* Group I received the vehicle,
* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,
* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,
* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,
* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and
* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.
At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to the Dexamethasone group.
According to the tested assays, Dexamethasone treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), and vascular reactivity changes to Catecholamine, compared to the control group.
Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone-administered rats significantly (p<0.05) demonstrated a significant reversal of such change.
Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".
In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)
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