#CruciferousVegetables In the Inhibition of #ChemicalCarcinogens that Cause the Onset of Cancers, According to Studies

By Kyle J. Norton

Cruciferous vegetables rich in phytochemicals may be the food for reduced risk and treatment of chemical carcinogens

According to the Universidade Federal de Ouro Preto, sulforaphane (SFN), the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetables expressed chemopreventive properties involved in detoxification processes of chemical carcinogens.

Dr. de Figueiredo SM, the lead author said, " In a dose-dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells, and presents anti-inflammatory effect acting during the initial of uncontrolled cell proliferation."

Chemical carcinogens are types of cancer caused by chemical toxins in the induction of cellular and chromosome change, DNA damage, etc.

The chemoprotective activity of the vegetable is the result of the significant expression of the antioxidants in cell cycle arrest and apoptosis in cancer cells as well as acting as the post-initiation stages of carcinogenesis, as a 'suppressing' agent involving the ability to modulate the Nrf2 in reduced damage from oxidative damage.

In fact, besides use as a chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN), the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protects normal healthy cells from environmental toxin-induced of cancers.

Furthermore, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, in reduced oxidate stress, and free radicals produced by lipid peroxidation in cells.

In the study of tobacco smoke carcinogens-induced chemical tumors, cruciferous vegetable consumption has been shown to be inversely associated with the development of cancer. In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetables, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function in metabolized potentially toxic compounds.

Taking together, the intake of cruciferous vegetables has potential health benefits against environmental toxins in cancer development, but due to the small size of the sample, further studies are necessary to address its viability.


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Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)

#Herbal #Calendula Inhibits the Excessive Meibomian Gland Secretion.That Causes #ChronicBlepharitis, Researchers Suggest

By Kyle J. Norton

Herbal Calendula may have a potential effect in reducing the risk and treatment of chronic blepharitis, some scientists suggested.
Blepharitis is a condition caused by the eye inflammation of the eyelids or parts of the eyelids as a result of the clogging of tiny oil glands located near the base of the eyelashes, affecting people of all ages.

Blepharitis can be classified into 2 types1. Acute blepharitis is referred to as eyelid infection by bacterial, viral, or parasitic pathogens.

2. Chronic blepharitis or lid inflammation is caused by staphylococcal, seborrheic, and meibomian gland dysfunction (MGD) that lasts more than 3 months.

According to researchers, chronic blepharitis is difficult to treat due to persistently low-grade inflammation.

The most common causes of blepharitis are bacterial infection. However, the condition also can be caused by a skin condition, such as scalp dandruff or rosacea.

If you experience symptoms of itchiness, redness, flaking, and crusting of the eyelids, burning sensation, irritation, tearing, and red eyes, you may have acute blepharitis, please check with your doctor.

Untreated chronic blepharitis can lead to permanent alterations to the eyelid margin or vision loss from superficial keratopathy (abnormality of the cornea), corneal neovascularization, and ulceration.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.


The herb has been used in herbal medicine as spasmolytic, spasmogenic, and inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.


In the findings of the natural ingredient with potential for the treatment of chronic blepharitis without inducing any adverse effects, Dr. Prozornaia LP and Dr. Brzhevskiĭ VV.launched an investigation to examine the herbal Calendula anti-chronic blepharitis activity.

In a total of 110 patients aged from 3 to 42 years old were examined to estimate the efficacy of chronic blepharitis treatment, 50 patients are with chronic blepharitis and dry eye syndrome (DES), 28 are with DES due to computer vision syndrome and 32 are with isolated chronic blepharitis.

All patients received eyelid massage and a complex of hygienic procedures was performed using phytoproducts ("Geltec-Medika", Russia): blepharoshampoo, blepharolotion, blepharogel 1 and 2.


After all the procedures were finished, moist warm pads (with blepharolotion and calendula extraction) were applied to the eyelids of 25 patients.

In comparison to massage, moist warm pad treatment exerts a significant effect in the improved efficacy of background therapy in patients with meibomian gland hypofunction but an insignificant effect in patients with excessive meibomian gland secretion.

These results suggested that Herbal Calendula may be effective in the treatment of chronic blepharitis caused by meibomian gland hypofunction if it is used in conjunction with eyelid hygiene.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) [Efficacy of physiotherapy and hygienic procedures in the treatment of adults and children with chronic blepharitis and dry eye syndrome].[Article in Russian] by Prozornaia LP, Brzhevskiĭ VV.(PubMed)
(2) Interventions for chronic blepharitis by Kristina Lindsley,1 Sueko Matsumura,1 Elham Hatef,2 and Esen K Akpek. (PubMed)

#DriedPeas and #BeanFibers in Attenuating the Risk of #MetabolicSyndrome, According to Studies

By Kyle J. Norton

Intake of dried peas fiber daily and regularly may reduce the risk of metabolic syndrome, some institute studies suggested.

Metabolic syndrome is a biochemical and physiological factor associated with the risk of cardiovascular disease and type 2 diabetes.

The dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with a healthy source of proteins, fibers, vitamins, and minerals.

In the study to investigate the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans, and lentils), compared with counseling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the MetSyn of in 2 groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults, researchers after adjusting to many confounders after 8 weeks of the experiment suggested that
1. Pulse group expressed an HDL and C-peptide increased by 4·5 and 12·3 %, respectively compared to a decrease by 0·8 and 7·6 %, respectively, in the energy-restricted group.
2. Insulin AUC decreased in both females and males on the energy-restricted diet by 24·2 and 4·8 %, respectively, and on the pulse diet, it fell by 13·9 % in females and 27·3 % in males respectively.

Based on the result interpretation, Dr. Mollard RC, the lead author said," Frequent consumption of pulses in an ad libitum diet reduced risk factors of the MetSyn".

C-peptide is a substance produced by the beta cells in the pancreas with the function to connects insulin's A-chain to its B-chain in the insulin molecule.

Insulin AUC is the area under the curve in a 2 dimension coordinate used to measure the insulin concentration in blood insulin vs. time.

Unfortunately, the method used to calculate AUC may affect the interpretation of whether or not an intervention was effective, according to some researchers.

In support of the above study, the Fahan University of Medical Sciences conducted a cross-sectional study of 425 subjects 35 to 55 y of age, using a food-frequency questionnaire. including in the report of blood pressure, waist circumference, glucose, triacylglycerols, and high-density lipoprotein cholesterol to measure the risk of the metabolic syndrome defined based on Adult Treatment Panel III guidelines, after examining the returned questionnaire, researchers found that daily intake of these groups of the population can be classified into 5 patterns, namely,

1. A Western pattern (high in sweets, butter, soda, mayonnaise, sugar, cookies, the tail of a lamb, hydrogenated fat, and eggs)
2. A prudent pattern (high in fish, peas, honey, nuts, juice, dry fruits, vegetable oil, liver and organic meat, and coconuts and low in hydrogenated fat and non-leafy vegetables)
3. A vegetarian pattern (high in potatoes, legumes, fruits rich in vitamin C, rice, green leafy vegetables, and fruits rich in vitamin A),
4. A high-fat dairy pattern (high in high-fat yogurt and high-fat milk and low in low-fat yogurt, peas, and bread),
5. A chicken and plant pattern (high in chicken, fruits rich in vitamin A, green leafy vegetables, and mayonnaise and low in beef, liver, and organic meat)

And in comparison to all 5 groups
1. The western pattern was associated with greater odds of having increased triacylglycerol and blood pressure
2. The prudent pattern was positively associated with a prevalence of low high-density lipoprotein cholesterol levels
3. The vegetarian dietary pattern was inversely associated with a risk of an abnormal fasting blood glucose level

Adult Treatment Panel III guideline is used as a classification of LDL, Total, and HDL Cholesterol (mg/dL).

Dr. Amini M, the lead author emphasized, " Major dietary patterns were significantly associated with the risk of metabolic syndrome".

In other words, there is no specific diet pattern that can be considered a daily diet in reducing the risk of metabolic syndrome. The mix of ingredients of the above diet selectively may be necessary for people who are at higher risk of such syndrome

Interestingly, in the study to develop baked and extruded functional foods from Metabolic Syndrome (MS) specifically designed ingredient mixes with optimum amino acid makeup using key food ingredients with functional properties such as whole cereals, legumes, skimmed milk powder, along with flaxseeds and fenugreek seeds, researchers after taking into account of other confounders suggested that six ingredient mixes from above of bread and four ingredient mixes each of extruded snack and noodles showed a specifically designed for MS patients who had significantly (p ≤ 0.05) higher lysine, crude protein, ash and fiber and low carbohydrates in compare control whole wheat flour products, hence appropriate for MS patients.

Taking all together, dried peas and bean fibers may be used in conjunction vegetarian diet to provide a strong impact in ameliorating the risk and treatment of the metabolic syndrome.


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Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults by Mollard RC1, Luhovyy BL, Panahi S, Nunez M, Hanley A, Anderson GH.(PubMed)
(2) Development of baked and extruded functional foods from metabolic syndromespecific ingredient mix by Miglani N1, Bains K1, Kaur H1.(PubMed)
(3) Relationship between major dietary patterns and metabolic syndrome among individuals with impaired glucose tolerance.
Amini M1, Esmaillzadeh A, Shafaeizadeh S, Behrooz J, Zare M.

The Effects of #Catsclaw on #Parkinson's disease, Scientists Suggest

By Kyle J. Norton

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc...

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

Parkinson's disease is a type of dementia caused by nerve cell dysfunction that produces dopamine in the brain, affecting muscle rigidity, tremors, and changes in speech and gait.

Uncaria tomentosa may be one of the medicinal plants used for reduced symptoms and treatment of Parkinson's disease.

According to a recent study, AC11 (a standardized aqueous extract of Uncaria tomentosa) exhibited scavenging several types of free radicals, decreased lipid peroxidation level and reduced α-synuclein aggregation by 40%.


Dr. Cosentino C. the lead researcher at the Instituto de Ciencias Neurological, said, "Uncaria tomentosa (UT),,... reversed worsening of motor signs in a patient with Parkinson's disease after oral intake"

Further study of Cat's Claw (Uncaria tomentosa) also found that the medical plant enhanced DNA repair and immunity in model systems with the capability of generating neuroprotective effects in neurons.

Although the therapeutic intervention of Cat's claw may exhibit properties against Parkinson's disease, using the medicinal plant should be taken with care.



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Sources
(1) Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model byShi Z1, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B.(PubMed)
(2) Reversible worsening of Parkinson's disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw) by Cosentino C1, Torres L.(PubMed)
(3) Quinic acid could be a potential rejuvenating natural compound by improving the survival of Caenorhabditis elegans under deleterious conditions by Zhang L1, Zhang J, Zhao B, Zhao-Wilson X.(PubMed)

#Betanin Protects the Digestive Tract DNA Against Damages that Cause Inflammatory Bowel Disease, Researchers Say

By Kyle J. Norton

Inflammatory bowel disease (IBD) is a class of chronic conditions associated with the inflammation of the gastrointestinal tract, including
* Ulcerative colitis is a chronic inflammation and ulcers found in the innermost lining of the colon and rectum.

* Crohn's disease. is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.

The most common symptoms of IBD are severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.


If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.

The causes of IBD are unknown. However, some researchers suggested that the promotion of a high-fat diet over the past few decades that cause the alternation of the ratio of gut microbiota may be the major culprit in facilitating the onset of IBD.

The research of Case Western Reserve University, wrote, "A high-fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation -- a major discovery for patients suffering from Crohn's disease, research indicates. Crohn's disease, a type of inflammatory bowel syndrome, causes debilitating intestinal swelling, cramping, and diarrhea".

Betanin is a phytochemical in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a treatment for inflammatory bowel disease (IBS), researchers examined the effect of beetroot (Beta vulgaris var. Rubra) products and their major component betanin on the reactive oxygen species (ROS) production and DNA damage in vitro.

In neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), injection of betanin at 100 μM for 24 h increased DNA damage, according to the comet assay.

However, in Caco-2 cells. injection of betanin at 100 μM for 24 h showed a lesser pronounced stimulation of DNA damage.

Treatment of Caco-2 cells with H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.

In other words, betanin exerted a cytotoxic effect against the DNA-alternated cells but inhibited the free radical expression in the induction of DNA damage in normal cells.

More precisely, betanin led to the release of ROS and apoptotic cell death.

Based on the findings, researchers wrote, " betanin may exert anti-inflammatory and potentially cancer-preventive activity".

Taken altogether, betanin may be considered a supplement for the prevention and treatment of inflammatory bowel disease, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High fat diet reduces gut bacteria, Crohn's disease symptoms by Case Western Reserve University. (Science Daily)

#Herbal #Catnip in the Inhibition of the Risk and Progression of #LungCancer, Researchers Say

By Kyle J. Norton

Catnip may have a potential and substantial effect in reducing the risk and treatment of lung cancer, some scientists suggested.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia, used in herbal medicine as an insect repellant and to treat digestive disorders, children's restlessness and nervousness, fevers, colds, and flu, skin irritations stimulate sweating, promote menstruation, etc...

Ingredients
Terpenoid nepetalactone, α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc...

Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistics, In 2015, approximately 26,600 Canadians will be diagnosed with lung cancer and 20,900 will die of it.

According to the investigation of the anti-cancer effect of extracts isolated from catnip containing sub-fractions (ND-1-ND-15) of ND using human lung cancer cells (A-549) experiment, the selected sub-fractions of the chloroform extract demonstrated significant activity in reduced the cell viability of A-549 cells, through alternated the cancer cell structures and arrangement in a concentration-dependent manner.

In a classification of the effect of each individual subfraction, researchers found that the ND-10 fraction induces the greatest cytotoxicity in the lowest dose compared to other fractions with ND-1 does not cause any cytotoxicity even at higher concentrations.

In comparison to other cancer cell lines, human lung cancer cells (A-549) were found to be more sensitive to the application of the extracts.

Further differentiation of the Nepeta cataria L. anti-cancer treatment effect was recorded in the Chinese Pharmacopoeia of version 2015 and belongs to one of the Traditional Chinese medicine (TCM). Microfluidic chip technology, researchers at the joint study led by the Liaoning University of Traditional Chinese Medicine conducted a study based on total flavonoid extracted from Nepeta cataria L. (TFS) on the risk of human lung cancer cell line A549 using the microfluidic device and Flow Cytometry assays, suggested that the bioactive chemicals exert a significant activity in inhibited cancer cell proliferation and tumor progression and invasion through mRNA expression of MicroRNA-126 (miR-126) which plays an important role involved in post-transcriptional regulation of gene expression in inhibition of human cancer progression, regulating apoptosis of cancer cells.

Additionally, the anti-lung cancer expression was attributed to ameliorating the vascular endothelial growth factor (VEGF), a potent angiogenic factor with the function to trigger the development of new blood vessels to supply nutrients and oxygen to ignite cancer cell proliferation and inhibited the expression of the PI3K signaling pathway which is correlated to the cancer aggression and invasive malignancy.

Researchers also indicated that according to the Flow Cytometry assay, the phytochemicals also exhibit the expression of PTEN (phosphatase and tensin homolog deleted on chromosome 10) PTEN gene in initiated tumor suppressible activity through expression PI3K-AKT pathway in induced cell cycle arrest or apoptosis in human cancer cells

Dr. Jiaxin Fan, the lead author, after taking into account other confounders said, " Taking all these results into consideration we can draw a conclusion that TFS may be used as a novel therapeutic agent for NSCLC in the near future".

The information findings postulated that herbal catnip with abundant bioactive compounds may be considered a functional food in reduced risk and treatment of human lung cancer, depending on further differentiation.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Anticancer Activity of Chloroform Extract and Sub-fractions of Nepeta deflersiana on Human Breast and Lung Cancer Cells: An In vitro Cytotoxicity Assessment by Al-Oqail MM1, Al-Sheddi ES1, Siddiqui MA2, Musarrat J2, Al-Khedhairy AA2, Farshori NN1.(PubMed)
(2) Mechanism of modulation through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer by Jiaxin Fan,#1 Yongrui Bao,#1,2,3,4 Xiansheng Meng,1,2,3,4 Shuai Wang,1,2,3,4 Tianjiao Li,1,2,3,4 Xin Chang,1 Guanlin Yang,1 and Tao Bo4(PMC)

#Healthyfood #Broccoli Inhibits the #OxidativeStress that Promotes #NeurodegenerativeDiseases (NDDs), According to Studies

By Kyle J. Norton

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, and medical conditions, such as alcoholism, brain cancer, or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.

Another risk factors associated with the disease prevalence are the increase in age, the most consistent risk factor for developing a neurodegenerative disease, especially AD or PD, as the disease has been found in over 60% of the population aged 65 and beyond compared to another group.

A prolonged period of toxins and toxic chemicals accumulated that affect brain function also has a strong impact to induce the onset of the disease.

The progressive loss of neurons induced neurological and neuropsychological signs and symptoms have also been found in comparison to the stage of disease onset of patients.

Dementia is a condition of deterioration of the cognitive ability of memory, thinking, language, judgment, and behavior, gradually.

The loss of mental ability in patients with dementia in most cases is severe enough to interfere with people's every life. Alzheimer's disease is the most common type of dementia in aging people.

According to the statistics, about 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years and above that age.


Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

According to the WHO, neurological disorders, ranging from epilepsy to Alzheimer's disease, from stroke to headache, affect up to one billion people worldwide.

On finding a potential plant that treats age-related diseases, researchers examined the effects of sulforaphane (SF), derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, anti-neuroprotective effects


The study included 16 subjects randomized, into a 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.

According to the results of the trial,
* Sulforaphane (SF) inhibited the oxidative stress that results from an imbalance of pro-oxidant/antioxidant homeostasis associated with abnormal production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the damage of neurons-induced neurodegenerative diseases (NDDs).

* In a neonatal hypoxia/ischemia brain injury model, SF significantly increased Nrf2 and HO-1 expression involved in the production of antioxidants enzymes in the host against oxidative stress accompanied by reduced infarct volume.

* In a rat model of traumatic brain injury (TBI), the postinjury administration of SF reduced the BBB impairment and cerebral edema after TBI.


* In chronic degenerative diseases, SF inhibited the increase of oxidative stress, the impaired protein-folding function of the endoplasmatic reticulum, and deficient proteasome- and autophagic-mediated clearance of damaged proteins accelerated the accumulation of Aβ peptides and Tau protein in AD.

Taken altogether, the consequences of these results suggest that the broccoli process abundantly SF may be considered a functional food for the prevention and treatment of neurodegenerative diseases (NDDs), pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases by Andrea Tarozzi, 1 Cristina Angeloni, 1,* Marco Malaguti, 1 Fabiana Morroni, 2 Silvana Hrelia, 1and Patrizia Hrelia. (PMC)