#Bromelain Inhibits the Antibodies Against the Onset of #LungCancer, Researchers Find

By Kyle J. Norton

Lung cancer is a chronic condition characterized by irregular cells in the lung tissues caused by the alternation of cells' DNA.

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream, and exhaling carbon dioxide from the bloodstream.

According to the statistics, in the US, lung cancer is the leading cause of cancer deaths. In n 2007. lung caused the death of 158,683 Americans, including 88,329 men and 70,354 women i

There are several types of lung cancer including
1. Non-small cell lung cancer
Non-small cell lung cancer, the most common type of lung cancer grown and spread methodically and predictably, includes
* Squamous-cell carcinoma often found in an outer area of the lung.

*Large-cell carcinoma found in the center of the lung by an air tube.

* Adenocarcinoma found in any part of the lung.

2. Small cell lung cancer
Small cell lung cancer is an aggressive type of lung cancer. The cells of small cell cancer have been found to spread to distant parts of the body in a relatively early stage.
* Small cell carcinoma in which the cells are small, round, and resemble oats.

* Mixed small cell/large cell carcinoma, the malignant tumor is found in combining components of small cell lung carcinoma with large cell lung carcinoma.

* Combined small cell carcinoma, the malignant tumor is found in combining of a component of small cell lung carcinoma with components of non-small cell lung carcinoma

Out of many risk factors associated with the onset of lung cancer, some researchers suggested smokers are at substantial risk of the disease.

Dr. Ozlü T the lead scientist wrote, "It is estimated that deaths attributable to tobacco use will rise to 10 million by 2025, and one-third of all adult deaths are expected to be related to cigarette smoking".


And, "Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking. The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers".

The results strongly suggested that if you are a smoker, your risk of lung cancer developing is rocketing.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient against lung cancer, researchers examined the effects of the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa on the intravenous model of lung colonization in C57Bl/6 mice.

According to the tested assays, fastuosain showed reduced expression of the marker of cancer progression (CD44) and decreased invasion by inhibiting cancer cell communication and inflammation in tumor cells.

Furthermore, fastuosain also induced cancer apoptosis by blocking the function enzymes associated with cell proliferation.

Interestingly, in green fluorescent protein-chimeric animals, treatment with fastuosain did not change the number of cells that migrated to the lung, compared to PBS-injected control mice, but the number of positive major histocompatibility complex class II cells associated with antigens was increased significantly.

In other words, fastuosain anti-lung cancer activity is mainly involved in the direct effect of the enzyme and elicitation of protective antibodies.

Taken altogether, bromelain may be considered supplements for the prevention and treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa by Guimarães-Ferreira CA1, Rodrigues EG, Mortara RA, Cabral H, Serrano FA, Ribeiro-dos-Santos R, Travassos LR. (PubMed)
(2) Melanoma heterogeneity: differential, invasive, metastatic properties and profiles of cathepsin B, D and L activities in subclones of the B16F10-NEX2 cell line by Freitas ZF1, Rodrigues EG, Oliveira V, Carmona AK, Travassos LR. (PubMed)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)

#Allicin Stimulates the Immune Cells Against the Risk of #PancreaticCancer, According to Researchers

By Kyle J. Norton

Scientists may have found a single ingredient isolated from garlic for the prevention and treatment of pancreatic cancer with no side effects, according to studies.

Cancer of the pancreas or pancreatic cancer is a medical condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably.

Most pancreatic cancers start in the ducts (an exocrine component of the pancreas) that carry pancreatic juices. Pancreatic cancers originating in the glandular tissue account for over 75 - 90% of all cases of exocrine cancers.

At the advanced stage, cancerous cells from the pancreas may travel a distance away to exhibit secondary metastasis.

In Canada, the 5-year net survival including all stages of pancreatic cancer is 8%. In other words, 92% of people diagnosed with pancreatic cancer will die after 5 years.

According to the statistic provided by the American Cancer Society, every year, approximately an estimated 55,000 adults (29,000 men and 26,000 women) in the United States are diagnosed with pancreatic cancer. The incidence rates are 25% higher in black people, compared to white people.

Researchers do not know the causes of the disease. However, age, gender, ethnicity, smoking habit, poor diet, and certain medical condition such as diabetes are associated with the prevalent risks of pancreatic cancer.

Some researchers suggested that pancreatic cancer is also found in high numbers in obese patients and patients with a family history of the disease, compared to others.

Dr. Silverman DT in the assessment of risk factors for pancreatic cancer, in a population-based case-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and ten New Jersey counties from August 1986 through April 1989, including 526 incident cases and 2,153 population controls. wrote, "elevated body mass index and caloric intake had increased risk".

And, " A three-fold risk of pancreatic cancer among first-degree relatives of affected individuals was apparent. Increased risk also was associated with a family history of colon, endometrial, ovary, and breast cancer, suggesting a possible link to hereditary non-polyposis colon cancer".

Allicin is phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

In finding the natural compound for the treatment of pancreatic cancer with no side effects, researchers evaluated the efficacy of combined treatment of the recombinant interleukin-2 (rIL-2) and allicin on pancreatic cancer.

The study includes a total of 60 C57/BL6 nude mice pancreatic cancer xenograft models randomized and assigned into four groups of 15 mice per group: control group, allicin treatment group, rIL-2 treatment group, combined treatment with allicin, and rIL-2 group.

Mice in each group were treated with saline, rIL-2, allicin, or a combination of rIL-2 and allicin by weekly i.v injection for four weeks.

Treatment with the allicin and rIL-2 group significantly suppressed the xenograft growth and prolonged survival time, compared to other groups. Truly, the combined therapy group exerted the most amounts of apoptotic cells.

The combined treatment group anti-pancreatic cancer efficacy was attributed to the activation of levels of CD4+T, in stimulating other immune cells, killing cancer cells, and natural killer cells.

Furthermore, allicin and rIL-2 also increased the levels of Interferon-gamma (IFN-γ), a cytokine produced by a variety of cells involved in the immune response against cancer cells, compared to other groups.

Dr. the lead researcher wrote in the final paper, "Combined treatment with allicin and rIL-2 resulted in suppression of tumor growth and prolonged survival time possibly through activation of CD4+T, CD8+T and NK cell".

Taken altogether, allicin isolated from the garlic may be considered a bioactive ingredient for the prevention and combined with the primary therapy for the treatment of pancreatic cancer.

However, intake of allicin in the form of a supplement should be taken with extreme care in the prevention of overdose toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Effect of combined treatment with recombinant interleukin-2 and allicinon pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogs on cancer cell lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
(3) Risk factors for pancreatic cancer: a case-control study based on direct interviews by Silverman DT1. (PubMed)

#Turmeric In Reducing the Risk of #DiabeticNeuropathy, Researchers Suggest

By Kyle J. Norton

Diabetic neuropathy is a complication of patients with diabetes associated with nerve damage, ranging from pain and numbness in your legs and feet to problems with your digestive system.

Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.

Diabetic neuropathy can be classified into 4 main types, including.
* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.

* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs, and eyes.

* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.

* Mononeuropathy or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso), or leg.

The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage of nerves and blood vessels in the affected area has been found to induce by over time, uncontrolled high blood sugar.

In other words, diabetic neuropathy is preventable by keeping the blood glucose in the healthy range.


Dr. Michael Greger M.D. FACLM in the article "the best diet for diabetic neuropathy" wrote, "
(By examing) people eating different diets found that nine months or more on a strict plant-based diet appeared to remove the trans fat from their bodies (or at least their butts). Their pain, however, didn’t take nine months to get better—it got better in days"

In the explanation of the results, the researcher continued, "More likely, it was due to an improvement in blood flow. “[N]erve biopsies in diabetics with severe progressive neuropathy…have shown small vessel disease within the nerve.” There are blood vessels within our nerves that can get clogged up too. The oxygen levels in the nerves of diabetics were found to be lower than even the levels of oxygenated blood".


Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential ingredient for the treatment of diabetic neuropathy researchers examined the turmeric antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property.

According to the results of the experiment, turmeric inhibited the pathogenesis of diabetic neuropathy by improving the antioxidant in the reduction of the level of oxidative stress associated with the occurrence of the present complication.

Furthermore, turmeric also enhanced the anti-inflammatory and antibacterial activity against the spread of infection.

In other words, turmeric inhibited diabetic neuropathy through a number of mechanisms involved in the antioxidant, anti-inflammatory, and antibacterial activity.

In order to review more information about the turmeric effect, researchers investigated Nishamalaki (NA), a combination of Curcuma longa and Emblica officinalis in the prevention of diabetic neuropathy.

The study included diabetic neuropathy in type 2 diabetic Wistar rats under treatment of 12 weeks.

Selected rats were randomly divided into group I (Control) vehicle-treated consists of 6 rats and
group II-VII Diabetic Control, NA low dose, NA High dose, Glibenclamide, Pioglitazone and Epalrestat respectively.

Diabetes-induced in 36 Wistar rats with Streptozotocin (STZ) (35mg/kg) intraperitoneally followed by a High Fat High Fructose diet. After confirmation of the development of diabetes; rats were divided into six groups as the aforementioned division.

Compared to other treatment groups, Nishamalaki (NA) not only controlled hyperglycemia and reduced lipid levels but also effectively prevented the development of diabetic neuropathy.

Taken altogether, turmeric used alone or combined with other herbal medicine may be considered supplements for the prevention of diabetic neuropathy, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy by Grover M1, Shah K2, Khullar G3, Gupta J1, Behl T. (PubMed)
(2) Evaluation of Effect of Nishamalaki on STZ and HFHF Diet-Induced Diabetic Neuropathy in Wistar Rats by Dawane JS1, Pandit VA2, Bhosale MS3, Khatavkar PS. (PubMed)(3) Best Diet for Diabetic Neuropathy. Written By Michael Greger M.D. FACLM on January 1st, 2019

#Tomato In Reducing the Risk of #CardiovascularDiseases in #Diabetics, Scientists Show

By Kyle J. Norton

Oxidative stress is an imbalanced ratio of free radicals and antioxidant enzymes produced by the host.
In other words, diseases associated with oxidative stress such as cardiovascular diseases [CVDs],

 chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer are results of the prolonged period of overexpression of free radicals compared to reduced levels of antioxidants.

Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order to become stable, free radicals readily steal or donate an electron from other molecules, leading to a free radical cascade that cannot be stopped until all outer ring electrons are paired or inhibited by antioxidants.

Antioxidants are stable molecules that inhibit oxidation.

Diabetes is a chronic condition of insufficient insulin entering the bloodstream, caused either by the gradual died-off of the beta cells in the pancreas or insulin receptors clogged up by cholesterol.

In our body, free radicals induced by cell metabolism for the body to function normally are inhibited by the antioxidant either produced by the body or the intake of antioxidant chemical compounds from dietary sources.

Free radicals can enter our body from environmental factors, such as the air we breathe, and the foods we eat.

Some researchers suggested that the reduced levels of antioxidants against the overexpression of free radicals most likely occurred in people with a weakened immune system such as the elderly due to aging.

Dr. Viviana I Pérez, the lead scientist said, "Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level".

And, "While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging".

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural compound for the treatment of diabetes with no side effect, researchers examined the beneficial effect of tomatoes in diabetics.

Participants with a type-II diabetic group (n=40) and an age-matched control group (n=50 are included in the study.

Before treatment, the type-II diabetic group showed significantly lower levels of antioxidant enzymes and a very high lipid peroxidation rate compared to the control group.

According to the analysis of the short term supplementation, tomatoes (cooked) showed a significant improvement in antioxidant enzyme levels and decreased lipid peroxidation rate in the diabetic group for a period of 30 days.


Once again, in the total of 90 subjects included type 2 diabetic group (n = 40) and an age-matched control group (n = 50), researchers once against investigated the anti-diabetes activity of lycopene.

Patients with type 2 diabetes have significantly lower levels of antioxidant enzymes and very high lipid peroxidation, as well as higher levels of lipid profile and glycated hemoglobin (HbA1c), compared to controls before the application of lycopene.

Long-term tomato supplementation in diabetes mellitus showed a significant improvement in the levels of antioxidant enzymes and decreased lipid peroxidation rate (p < 0.001), with no effect on lipid profile and glycated hemoglobin HbA1c levels.

In other words, long term tomato injection protects diabetics against complications associated with abnormally high levels of high blood glucose and lipid, through its antioxidant activity.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Effect of short-term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type-II diabetes by Subhash K1, Bose C, Agrawal BK. (PubMed)
(2) Effect of long-term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile, and glycated hemoglobin in Type 2 diabetes mellitus by Bose KS1, Agrawal BK. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)

#Strawberries in the Reducing the Risk and Management of #Hyperglycemia and #Hypertension with No Side Effects

By Kyle J. Norton

Strawberry is a genius of Fragaria × ananassa belonging to the family Rosaceae.
The tasty fruits have been grown all over the world in a suitable climate for commercial profits and for health benefits.

The major chemical compounds of strawberries include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Hypertension is a condition of abnormally high blood pressure.

High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress.

Sometimes it can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.

Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.

Dr. Duangtep Y, the lead scientist in the team on heart disease and stroke at the District Health Office, Mae Fah Luang in the examine the risk of an unhealthy lifestyle and hypertension wrote, "Multiple logistic regression analysis shows the factors associated with hypertension among the hill tribe people studied were smoking, no or irregular exercise, being overweight, having obesity, and having a high-frequency intake of fatty foods".

These results strongly indicated that by following a healthy lifestyle, hypertension is preventable.

Unfortunately, according to the statistics, approximately 75 million American adults (32%) have high blood pressure. In other words, high blood pressure affects 1 in every 3 adults in the US.

In the differentiation of the association of high blood pressure in the contribution to cardiovascular disease and stroke, some scientists indicated these results overwhelmingly suggested hypertension has become a global burden and a growing public health problem worldwide.

On finding a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Universidade de São Paulo assessed with the fruit extracts of different strawberry cultivars for their potential to inhibit hypertension.

According to the DPPH radical scavenging assay, the fruit extracts inhibited alpha-amylase, alpha-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potentially managing hyperglycemia and hypertension.

The Strawberries' high alpha-glucosidase and angiotensin I-converting enzyme (ACE) inhibitory activity were attributed to the presence of ellagic acid, quercetin, and chlorogenic acid.

Water extracts of Jewel and Ovation cultivars strawberry had moderated ACE inhibition compared to low inhibition observed in other cultivars.

In vitro, strawberry fruit extracts inhibited the expression of angiotensin-1-converting enzyme (ACE) activity correlated to phenolic content and antioxidant activity.

These results suggested that strawberries could be considered a potential dietary source with anti-hyperglycemic and antihypertensive potential.

Dr. Cheplick S, the lead author said, "Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension".

Furthermore, by examing the potential health benefits of purified ellagitannins from strawberries in relation to the antiproliferative activity and in vitro inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) relevant to the potential management of hyperglycemia and hypertension in patients with type 2 diabetes, researchers found that purified ellagitannins isolated from the strawberry have high α-amylase and ACE inhibitory activities.

However, these compounds had low α-glucosidase inhibitory activity.

In the final report of the experiment, Dr. Pinto Mda S, wrote, "The ellagitannins and ellagic acid have good potential for the management of hyperglycemia and hypertension linked to type 2 diabetes".

Taken altogether, adding a portion of strawberries to a daily diet may have a profound effect in reducing the risk and treatment of high blood pressure.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria × ananassa Duch.) using in vitro models, by Pinto Mda S, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K(PubMed)
(2) Phenolic-linked variation in strawberry cultivars for the potential dietary management of hyperglycemia and related complications of hypertension. Cheplick S, Kwon YI, Bhowmik P, Shetty K.(PubMed)
(3) Functionality of bioactive compounds in Brazilian strawberry (Fragariax ananassa Duch.) cultivars: evaluation of hyperglycemia and hypertension potential using in vitro models. by da Silva Pinto M, Kwon YI, Apostolidis E, Lajolo FM, Genovese MI, Shetty K.
(PubMed)
(4) Association between an unhealthy lifestyle and other factors with hypertension among hill tribe populations of Mae Fah Luang District, Chiang Rai Province, Thailand by Duangtep Y1, Narksawat K, Chongsuwat R, Rojanavipart P. (PubMed)

#Antioxidant #Betacyanins Inhibit the Risk and Treatment of #BladderCancer, Scientists Suggest

By Kyle J. Norton

Cancer is a group of medical and chronic conditions characterized by irregular cell growth in the tissue of a specific organ in the body.

Most cases of cancer start in the cell on the surface of the inner lining tissue of an organ. After penetrating deeper layers and colonizing the entire organ, the cancerous cells can spread to the healthy tissue of other organs through lymph and blood.

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer occurs when cell mass in the inner lining of the bladder forms a malignant growth or tumor. Bladder cancer developed in the bladder lining has also been found to spread through the bladder wall to nearby organs such as the prostate gland in men or the uterus in women.

Bladder cancer can be classified depending on its proliferation
* Superficial types of bladder cancer
The most recurrent type of bladder cancer has a characteristic of noninvasive. These types of bladder cancer can be controlled or removed by regular cystoscopy.

* Invasive types of bladder cancer
Invasive types of bladder cancer tend to spread after beginning in cells in the lining of the bladder. These types of cancer often require surgery by removing part or the whole bladder.

The exact causes of bladder cancer are not identified. However, smoking has been found to induce a substantial risk of bladder cancer incidence.

Dr. Neal D Freedman, the lead scientist wrote, "...the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".

And, "Compared to a pooled estimate of US data from cohorts initiated between 1963 and 1987, relative risks for smoking in the more recent NIH-AARP cohort were higher, with population attributable risks for women compared to those for men".

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment for the prevention and treatment of cancer, researchers examined Betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) tested, alone or in combination with vitexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L. in the proliferation rate in T24 bladder cancer cells.

According to the tested analysis,* Combination of BC and XVX exhibited a synergistic effect that inhibits proliferation in T24 cancer cells at 24 and 48 h but not after 72 h of incubation.

* The combination-induced apoptosis of T24 bladder cancer cells observed by means of fluorescence-activated cell sorting (FACS) analysis by increasing the expression in caspases associated with cell death programming.

The inhibition of the bladder cancer cell line was found to enhance the expression levels of the pro-apoptotic gene and inhibit anti-apoptotic and survival proteins.

Extrinsically, the administration of BC increased the activity of caspase 8, a protein associated with the induction of apoptosis.

Interestingly, the XVX, BC, and their combination induced cancer cell death without exhibiting a cytotoxic effect on normal and healthy human cells.

Based on the findings, Dr. Scarpa ES, the lead scientist said, "the efficacy and the mechanisms of the action of BC and XVX, extracted from edible plants, and suggested that a diet or a nutrition supplement, enriched with these bioactive molecules, could be used in the prevention of human bladder cancer".

Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of bladder cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Scarpa ES1, Emanuelli M2, Frati A1, Pozzi V2, Antonini E1, Diamantini G1, Di Ruscio G3, Sartini D3, Armeni T3, Palma F1, Ninfali P. (PubMed)
(3) Bladder Cancer by Kyle J, Norton
(4) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)

#Antioxidant #Alliin Inhibits the Risk of #ChronicInflammation, Researchers Suggest

By Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the invasion of harmful stimuli and pathogens.

In the acute phase of infection, the immune first line of defense white blood cells, macrophages stimulates the production of proinflammatory cytokines with an aim to destroy all invaders which try to enter the body.

Most cases of acute infection are stopped at this phase and the wound is healed quickly.

However, if the wound is too large, then the recovery may take a longer period of time and through 4 overlap recovery stages.

Any interruption in the overlapped recovery stage may cause the formation of scars, similar to those of overproduction of pro-inflammatory cytokines.

Diseases associated with chronic inflammation induced by protein, lipid, and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.

In other words, prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines due to an immune response that can not kill off all invaders in a set period between 3-8 weeks can result in serious and chronic diseases.

The results have been found to cause cell death and alternation of cell DNA.

Believe it or not, people with low-grade chronic inflammation are prone to psychological stress that links to a greater risk for depression, and heart disease. particularly the body's ability to regulate the inflammatory response and normal defense.

Out of many risk factors involved in the onset of chronic inflammatory diseases, some researchers suggested the promotion of a high-fat diet in the Western world may correlate to the rise of the condition.

Dr. Yehui Duan, the lead scientist wrote, "In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has been increasingly viewed as a significant modifiable risk factor for diseases such as diabetes and certain types of cancer".

And, "the recent scientific literature about HFD-induced inflammation and subsequent development of diseases and cancer, with an emphasis on mechanisms involved. Given the expanding global epidemic of excessive HFD intake, understanding the impacts of an HFD on these medical conditions, gaining great insights into possible underlying mechanisms, and developing effective therapeutic strategies are of great importance".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In the urgency to find a natural and potential compound for the treatment of diseases associated with inflammation, researchers examined the active component is alliin (S-allyl cysteine sulfoxide) anti-inflammatory activity.


Before incubated with alliin, lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes showed a significant increase in proteins involved in the production of pro-inflammatory cytokines, including IL-6, MCP-1, and Egr-1 in 3T3-L1 adipocytes exposed to 100 ng/mL LPS for 1 hour.

According to the tested assay in lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes incubated for 24 h with 100 μmol/L alliin, the bioactive compound inhibited such increase.

Furthermore, the overexpression of the phosphorylation of ERK1/2 associated with cell differentiation including cell death caused by LPS-induced inflammation in adipocytes was also decreased following alliin treatment.

Additionally, alliin prevented the expression of inflammation in facilitating the alternation of cell DNA by modulating the gene expressions involved in immune responses such as tumor-suppressive genes and inhibiting the genes related to cancer.

Dr. Saray Quintero-Fabián, the lead scientist wrote, " The present results have shown that alliin is able to suppress the LPS inflammatory signals by generating an anti-inflammatory gene expression profile and by modifying adipocyte metabolic profile".


Taken altogether, alliin may be considered a supplement for the prevention and treatment of diseases associated with inflammation, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes by Saray Quintero-Fabián,1,2 Daniel Ortuño-Sahagún,1 Manuel Vázquez-Carrera,3 and Rocío Ivette López-Roa. (Hindawi)
(2) Inflammatory Links Between High Fat Diets and Diseases by Yehui Duan,1,† Liming Zeng,2,† Changbing Zheng,3 Bo Song,3 Fengna Li,1 Xiangfeng Kong,1and Kang Xu. (PMC)