By Kyle J. Norton
Antioxidants are stable atoms that inhibit oxidation caused by free radicals.
Antioxidants besides being produced by the body, they can also come into the body from dietary sources, including second metabolites found in fruits and vegetables.
Free radical scavengers are types of antioxidants that inhibit free radicals before they can induce a chain of reactions, leading to the onset of oxidative stress.
Oxidative stress associated with chronic disease is caused by a long-term imbalanced ratio of free radicals and antioxidants. Oxidative stress has been found epidemiologically to induce proteins, lipids, and cellular damage, a major cause of heart disease, stroke, and diabetes.
Not all free radicals are bad, in a moderate amount, free radicals are necessary for the body's functioning, including the promotion of heart function in blood circulation.
In a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter the expression of free radicals induced by cell metabolism and the environment such as the air we breathe and the food we eat.
However, for people with a weakened immune system, intake of antioxidants from outside sources such as fruits and vegetables can be helpful.
The most common types of free radical scavengers produced by the human are catalases that protect the cell from oxidative damage by decomposed hydrogen peroxide to water and oxygen, glutathione peroxidase, a cytosolic enzyme produced by the body that dissolves hydrogen peroxide to water and oxygen, and peroxide radicals to alcohols and oxygen, and superoxide dismutase (SOD) that dissolves superoxide radical into either ordinary molecular oxygen or hydrogen peroxide.
Dr. V. Hajhashemi, the lead scientist wrote, "Free radicals are produced continuously in the cells as part of normal cellular function, however, excess production might play a role in the pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity".
And, " Many basic research studies and observational epidemiologic studies in humans suggest that antioxidants can prevent oxidative damage".
Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.
On finding a potent ingredient for the prevention of heart diseases associated with oxidative stress, researchers investigated the effects of beetroot juice (BTJ) and whole beetroot (BF) on high blood pressure.
The randomized, crossover design study included a total of 10 healthy males who consumed either 250 ml of BTJ, 300 g of BF, or a placebo drink.
According to the sample analysis,
* Trolox equivalent antioxidant capacity (TEAC) was 11.4 ± 0.2 mmol/L for BTJ compared to 3.4 ± 0.4 μmol/g of BF.
* Both BTJ and BF contained a number of polyphenols (1606.9 ± 151 mg/GAE/L and 1.67 ± 0.1 mg/GAE/g, respectively)
* Betaxanthins exerted a TEAC of 41.7 ± 0.7 mg/indicaxanthin equivalents/L and 7.5 ± 0.2 mg/indicaxanthin equivalents/100 g, respectively compared to betacyanins of 68.2 ± 0.4 mg/betanin equivalents/L and 19.6 ± 0.6 mg/betanin equivalents/100 g, respectively.
* Betanin contains the highest TEAC in both BTJ (~194 mg) and BF (~66 mg), betanin could not be detected in the plasma at any time point post-ingestion compared to other chemical compounds.
In other words, beetroot juice (BTJ) and whole beetroot (BF) showed high levels of antioxidants associated with increasing plasma NOx bioavailability.
Taken altogether, betaxanthins second to betacyanins may be considered an antioxidant remedy for the inhibition of free radicals, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans by Clifford T1, Constantinou CM2, Keane KM2, West DJ3, Howatson G2,4, Stevenson EJ. (PubMed)
(2) Are antioxidants helpful for disease prevention? by V. Hajhashemi,1,* G. Vaseghi,1 M. Pourfarzam,2, and A. Abdollahi. (PMC)
Monday, 15 May 2023
#Bromelain Maybe a Better Treatment for the #RheumaticDisease with No Side Effects, Compared to #NSAID, According to Studies
By Kyle J. Norton
Rheumatism or rheumatic disorder is a group of medical conditions associated with chronic, often intermittent pain that affects the joints and/or connective tissue.
The most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints, and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.
The most common types of rheumatism are
* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.
* Rheumatoid arthritis (RA) is a chronic disorder associated with inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many elders.
* Gout mostly affected one joint and is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.
* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.
* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of persistent joint swelling, pain, and stiffness
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.
The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combinations to those of nonsteroidal anti-inflammatory drugs (NSAID).
According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995 registered by 380 physicians, both treatments yielded similar results.
However, there was a 50% higher success rate in OE than for NSAID, compared to the initial and treatment situations.
OE also scored higher stratification according to propensity score.
Furthermore, in treatment duration of more than 30 days and joint diseases or fibromyalgia in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients' response compared to those of OE.
Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.
The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs
Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in an example of treatment with non-steroidal anti-inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton
Rheumatism or rheumatic disorder is a group of medical conditions associated with chronic, often intermittent pain that affects the joints and/or connective tissue.
The most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints, and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.
The most common types of rheumatism are
* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.
* Rheumatoid arthritis (RA) is a chronic disorder associated with inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many elders.
* Gout mostly affected one joint and is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.
* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.
* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of persistent joint swelling, pain, and stiffness
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.
The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combinations to those of nonsteroidal anti-inflammatory drugs (NSAID).
According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995 registered by 380 physicians, both treatments yielded similar results.
However, there was a 50% higher success rate in OE than for NSAID, compared to the initial and treatment situations.
OE also scored higher stratification according to propensity score.
Furthermore, in treatment duration of more than 30 days and joint diseases or fibromyalgia in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients' response compared to those of OE.
Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.
The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs
Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in an example of treatment with non-steroidal anti-inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton
#Herbal #Fennel Extract, A Potential Herbal Medicine in Reducing the Onset and Treatment of #ProstateCancer, Scientists Find
By Kyle J. Norton
Fennel may have potential and positive effects in reduced risk, progression, and treatment of prostate cancer, some scientists suggested.
Prostate cancer is a chronic condition characterized by abnormal growth of prostate tissue. At he later stage, the cancerous cells may travel a distance away to infect other healthy cells and tissues.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to investigate the effect of 5 herbal medicine in different quantities in some different formulas represented by FB, FM, PP, HF, and FBL101 on the risk of prostate cancer, including licorice, black cohosh, Dong Quai, false unicorn, and vitex berry root extracts, fennel seed extract, researchers at the National Institute of Health found that FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
In an androgen-independent human prostate cancer cell line CWR22R, all 5 formulas also inhibited the cancer cell proliferation without alternating levels of testosterone.
However, the administration of formula PP and FBL101 showed a significantly reduced VEGF level with function in the stimulated formation of new blood vessels in initiated proliferation in PC3 and CWR22R tumors.
Furthermore, intratumoral microvessel density measurement in the expression of tumor growth with aggressive tumor behavior was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, after taking into account other cofounders said, "Herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
These results demonstrated that fennel extract and other herbal components may be considered as preventive and therapeutic agents for the treatment of prostate cancer without indicating the efficacy of the individual herb.
The above differentiation was supported by the study of Alexandria University in the evaluation of anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, a widely used folk medicine for the treatment of prostate cancer.
According to the experiment, the application of the bioactive compound anethole exerted a strong activity against proliferation, clonal growth, and migration of PC-3 cells, through the generation of ROS in the induction of cytotoxicity through damage to the DNA of the cancer cells.
Additional analysis of the efficacy, the application also stimulated the penetration of essential oil anethole in permeabilization of the mitochondrial and lysosomal membranes of PC3 cancer cells in the induction of cancer cells death, executed by caspase-3 and -9 pathways and PARP cleavage in the induction of apoptosis.
Interestingly, injection of anethole isolated from fennel essential oil also induced elevation of the Bax/Bcl-2 protein ratio, in initiated the onset of prostate cancer cell death through cell cycle arrest.
Further observation of anethole action, researchers found that anethole inhibited prostate cancer cells through cell cycle arrest in the G2/M phase ameliorated by levels of cyclins D1, CDK-4, and c-Myc proteins in promoted cancer cell cycle progression and enhanced production of levels p21 and p27 in exhibited tumor suppressible activity.
Finally, anethole also suppressed NF-κB protein in the activated production of TNF-α in the induction of anti-apoptosis in prostate cancer cells.
Taken together, the findings strongly suggested that long-term intake of fennel and its bioactive anethole may have substantial implications in the prevention and treatment of prostate cancer. But intake of fennel supplement should be taken with care to prevent acute liver toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Anethole Inhibits The Proliferation Of Human Prostate Cancer Cells Via Induction Of Cell Cycle Arrest And Apoptosis by Elkady A(PubMed).
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD. (PubMed)
Fennel may have potential and positive effects in reduced risk, progression, and treatment of prostate cancer, some scientists suggested.
Prostate cancer is a chronic condition characterized by abnormal growth of prostate tissue. At he later stage, the cancerous cells may travel a distance away to infect other healthy cells and tissues.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to investigate the effect of 5 herbal medicine in different quantities in some different formulas represented by FB, FM, PP, HF, and FBL101 on the risk of prostate cancer, including licorice, black cohosh, Dong Quai, false unicorn, and vitex berry root extracts, fennel seed extract, researchers at the National Institute of Health found that FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
In an androgen-independent human prostate cancer cell line CWR22R, all 5 formulas also inhibited the cancer cell proliferation without alternating levels of testosterone.
However, the administration of formula PP and FBL101 showed a significantly reduced VEGF level with function in the stimulated formation of new blood vessels in initiated proliferation in PC3 and CWR22R tumors.
Furthermore, intratumoral microvessel density measurement in the expression of tumor growth with aggressive tumor behavior was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, after taking into account other cofounders said, "Herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
These results demonstrated that fennel extract and other herbal components may be considered as preventive and therapeutic agents for the treatment of prostate cancer without indicating the efficacy of the individual herb.
The above differentiation was supported by the study of Alexandria University in the evaluation of anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, a widely used folk medicine for the treatment of prostate cancer.
According to the experiment, the application of the bioactive compound anethole exerted a strong activity against proliferation, clonal growth, and migration of PC-3 cells, through the generation of ROS in the induction of cytotoxicity through damage to the DNA of the cancer cells.
Additional analysis of the efficacy, the application also stimulated the penetration of essential oil anethole in permeabilization of the mitochondrial and lysosomal membranes of PC3 cancer cells in the induction of cancer cells death, executed by caspase-3 and -9 pathways and PARP cleavage in the induction of apoptosis.
Interestingly, injection of anethole isolated from fennel essential oil also induced elevation of the Bax/Bcl-2 protein ratio, in initiated the onset of prostate cancer cell death through cell cycle arrest.
Further observation of anethole action, researchers found that anethole inhibited prostate cancer cells through cell cycle arrest in the G2/M phase ameliorated by levels of cyclins D1, CDK-4, and c-Myc proteins in promoted cancer cell cycle progression and enhanced production of levels p21 and p27 in exhibited tumor suppressible activity.
Finally, anethole also suppressed NF-κB protein in the activated production of TNF-α in the induction of anti-apoptosis in prostate cancer cells.
Taken together, the findings strongly suggested that long-term intake of fennel and its bioactive anethole may have substantial implications in the prevention and treatment of prostate cancer. But intake of fennel supplement should be taken with care to prevent acute liver toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Anethole Inhibits The Proliferation Of Human Prostate Cancer Cells Via Induction Of Cell Cycle Arrest And Apoptosis by Elkady A(PubMed).
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD. (PubMed)
#Turmeric, the Herbal Medicine in Reducing the Risk of #CognitiveDysfunction, Researchers Say
By Kyle J. Norton
Scientists may have found a herbal spice that processed bioactive ingredients for the treatment of neuro-disorder with no side effects, according to studies.
Neuroprotection is an action involved in the use of a natural substance to protect the integrity and viability of neurons against damage or death.
Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease.
The disease has been found to negatively influence the body's functioning, including balance, movement, talking, breathing, and heart function.
There are many risk factors that cause the onset of the progressive death of brain neurons. Genetic preposition, medical condition, such as alcoholism, brain cancer, or a stroke in the brain.
A prolonged period of toxins, and toxic chemicals accumulated that affect brain function also have a strong impact to induce the onset of the disease.
Out of many factors, some researchers suggested that the prevalence of obesity may process some negative implications in stimulating the rise of neurodegenerative disease in older adults in the Western world.
Dr. Daniel Shalev, the lead scientist wrote, "So how does obesity or diabetes contribute to a 50% increase in the risk of dementia?".
And, "Many of the same processes that affect coronary arteries and visceral organs also impact the brain. Inflammation leads to the activation of microglia and astrocytes. This causes the release of cytokines and reactive oxidants, ultimately leading to neuronal dysfunction or death. Critically, this process can unleash a vicious cycle: dying neurons can cause more inflammation, thereby creating a cascade of neurodegeneration".
The findings strongly suggested if you are obese, your risk of dementia is substantially higher compared to non-obese individuals.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound that processes neuroprotective activity, researchers evaluated the neuroprotective effects of extracts from the radix of C. aromatica (ECAs, Turmeric) on free radical damage cells.
The study included the model of oxidative stress damage (H2O2-damaged PC12 cells) induced by injection of 400 µM H2O2.
Compared to ECAs at the same doses, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric showed markedly the increase in the rate of neuron survival and enhancement of the antioxidant enzyme activities via the inhibition of the level of ROS.
In other words, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric exerted better neuron-protective and antioxidant activity than of ECAs.
Furthermore, the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) also attenuated the intracellular Ca2+ overloading in the induction of psychiatric overtones, such as depression, anxiety, cognitive dysfunction and decreased the activation of proteins and matrixes involved cell apoptosis, similar to those of ECAs.
The efficacy of the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) against the degeneration of neurons was attributed to the presence of the active compound diarylheptanoids.
Based on the finding, researchers wrote, "These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica".
In order to reveal more information about turmeric neuroprotective effects, researchers evaluated the effects of curcumin against nicotine-induced apoptosis, oxidative stress, and inflammation in an animal model.
This study included 60 adult male rats divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, and group 2 received 6 mg/kg nicotine. Groups 3, 4, 5, and 6 were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40, and 60 mg/kg i.p. respectively) for 21 days.
According to the Open Field Test (OFT), curcumin-treated groups (40 and 60 mg/kg) reduced nicotine-induced motor activity disturbances.
Before the injection of curcumin nicotine treatment showed an increase in lipid peroxidation observed by the overexpression of ROS, proinflammatory cytokines, and protein associated with neuron apoptosis in the hippocampus.
Furthermore, nicotine also reduced the activity of antioxidant enzymes in the tested rats in the hippocampus.
Injection of curcumin reversed all alternation by attenuating nicotine-induced apoptosis, oxidative stress, and inflammation; and elevating the levels P-CREB and BDNF associated with the improvement of cognitive function,
Taken altogether, turmeric and its bioactive compounds, particularly curcumin may be considered a supplement for the protection of neuron integrity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells by Liu J1, Zhang L1, Liu D1, Li B1, Zhang M. (PubMed)
(2) The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway by Motaghinejad M1, Motevalian M2, Fatima S2, Faraji F2, Mozaffari S. (PubMed)
(3) Metabolism and Memory: Obesity, Diabetes, and Dementia by Daniel Shalev and Melissa R. Arbuckle. (PMC)
Scientists may have found a herbal spice that processed bioactive ingredients for the treatment of neuro-disorder with no side effects, according to studies.
Neuroprotection is an action involved in the use of a natural substance to protect the integrity and viability of neurons against damage or death.
Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease.
The disease has been found to negatively influence the body's functioning, including balance, movement, talking, breathing, and heart function.
There are many risk factors that cause the onset of the progressive death of brain neurons. Genetic preposition, medical condition, such as alcoholism, brain cancer, or a stroke in the brain.
A prolonged period of toxins, and toxic chemicals accumulated that affect brain function also have a strong impact to induce the onset of the disease.
Out of many factors, some researchers suggested that the prevalence of obesity may process some negative implications in stimulating the rise of neurodegenerative disease in older adults in the Western world.
Dr. Daniel Shalev, the lead scientist wrote, "So how does obesity or diabetes contribute to a 50% increase in the risk of dementia?".
And, "Many of the same processes that affect coronary arteries and visceral organs also impact the brain. Inflammation leads to the activation of microglia and astrocytes. This causes the release of cytokines and reactive oxidants, ultimately leading to neuronal dysfunction or death. Critically, this process can unleash a vicious cycle: dying neurons can cause more inflammation, thereby creating a cascade of neurodegeneration".
The findings strongly suggested if you are obese, your risk of dementia is substantially higher compared to non-obese individuals.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound that processes neuroprotective activity, researchers evaluated the neuroprotective effects of extracts from the radix of C. aromatica (ECAs, Turmeric) on free radical damage cells.
The study included the model of oxidative stress damage (H2O2-damaged PC12 cells) induced by injection of 400 µM H2O2.
Compared to ECAs at the same doses, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric showed markedly the increase in the rate of neuron survival and enhancement of the antioxidant enzyme activities via the inhibition of the level of ROS.
In other words, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric exerted better neuron-protective and antioxidant activity than of ECAs.
Furthermore, the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) also attenuated the intracellular Ca2+ overloading in the induction of psychiatric overtones, such as depression, anxiety, cognitive dysfunction and decreased the activation of proteins and matrixes involved cell apoptosis, similar to those of ECAs.
The efficacy of the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) against the degeneration of neurons was attributed to the presence of the active compound diarylheptanoids.
Based on the finding, researchers wrote, "These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica".
In order to reveal more information about turmeric neuroprotective effects, researchers evaluated the effects of curcumin against nicotine-induced apoptosis, oxidative stress, and inflammation in an animal model.
This study included 60 adult male rats divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, and group 2 received 6 mg/kg nicotine. Groups 3, 4, 5, and 6 were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40, and 60 mg/kg i.p. respectively) for 21 days.
According to the Open Field Test (OFT), curcumin-treated groups (40 and 60 mg/kg) reduced nicotine-induced motor activity disturbances.
Before the injection of curcumin nicotine treatment showed an increase in lipid peroxidation observed by the overexpression of ROS, proinflammatory cytokines, and protein associated with neuron apoptosis in the hippocampus.
Furthermore, nicotine also reduced the activity of antioxidant enzymes in the tested rats in the hippocampus.
Injection of curcumin reversed all alternation by attenuating nicotine-induced apoptosis, oxidative stress, and inflammation; and elevating the levels P-CREB and BDNF associated with the improvement of cognitive function,
Taken altogether, turmeric and its bioactive compounds, particularly curcumin may be considered a supplement for the protection of neuron integrity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells by Liu J1, Zhang L1, Liu D1, Li B1, Zhang M. (PubMed)
(2) The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway by Motaghinejad M1, Motevalian M2, Fatima S2, Faraji F2, Mozaffari S. (PubMed)
(3) Metabolism and Memory: Obesity, Diabetes, and Dementia by Daniel Shalev and Melissa R. Arbuckle. (PMC)
#Healthyfood #Strawberries In inhibting the Risk of #HeartDiseases, According to Studies
By Kyle J. Norton
Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
Besides cancer, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease. There are many causes of heart disease.
Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
Besides cancer, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease. There are many causes of heart disease.
Most heart diseases are caused by high blood pressure contributes to the hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of an uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin
Anthocyanin-rich foods, blueberries, and strawberries intake are found to be the potential in preventing myocardial infarction (MI) in young and middle-aged women, according to studies, as it is associated with a decreased risk of MI in comparison to those consuming >3 servings a week and those with lower intake.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin
Anthocyanin-rich foods, blueberries, and strawberries intake are found to be the potential in preventing myocardial infarction (MI) in young and middle-aged women, according to studies, as it is associated with a decreased risk of MI in comparison to those consuming >3 servings a week and those with lower intake.
In other studies, the water-soluble pigments, Anthocyanins display a wide range of biological activities including antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic activities and a variety of effects on blood vessels, platelets, and the risk of coronary heart diseases. In fact, Dietary intakes of flavanones, anthocyanidins, and certain foods rich in flavonoids were associated with reduced risk of death due to CHD, CVD, and all causes.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women by Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB. (PubMed)
(2) Anthocyanins and heart health by Mazza GJ. (PubMed)
(3) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. by Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr.(PubMed)
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women by Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB. (PubMed)
(2) Anthocyanins and heart health by Mazza GJ. (PubMed)
(3) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. by Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr.(PubMed)
#GreenBean, The #Healthyfood in the Prevention of #CardiovascularDiseases (#CVD), Researchers Find
By Kyle J. Norton
Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle.
Depending on the types of blood vessel damage or blocked, and heart muscle damage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart or a stroke caused by reducing oxygen supply to the brain cells.
Heart disease is a class of conditions associated with blood vessels and heart muscle that affect heart functioning, including coronary artery disease; heart rhythm problems (arrhythmias); and heart defects.
Coronary artery disease is a condition in most cases associated with an inflammatory cholesterol-containing plaque in the arteries.
A stroke can be caused by reduced blood flow or small blood vessel bleeding, leading to the death of neurons that affect parts of the brain's functioning.
Heart failure, a major health problem associated with the reduced function of the heart affects more than 6.5 million Americans, a leading cause of hospitalization in people older than age 65.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.
Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.
There are many prevalent factors associated with cardiovascular disease including family history, age ethnicity, gender, and medical conditions such as cholesterol high blood pressure, and diabetes.
Some researchers suggested overconsumption of carbohydrates over the long term may be one major condition that causes the onset of CVD.
Dr. Norman J. Temple in the examination of the effect of fat, sugar, whole grains in the risk of heart disease wrote, " The evidence linking carbohydrate-rich foods with CHD has been steadily strengthening. Refined carbohydrates, especially sugar-sweetened beverages, increase the risk of CHD. Conversely, whole grains and cereal fiber are protective. An extra one or 2 servings per day of these foods increases or decreases risk by approximately 10% to 20%.".
In other words, the intake of a high amount of carbohydrates is associated with an increased risk of CVD.
Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belongs to the family Fabaceae, and is native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.
In finding a portent compound for the prevention of cardiovascular disease, researchers compared
the antithrombotic activity in participants in central Chile.
The study included extract samples of 19 fruits and 26 vegetables from the local diet. Prepared from each sample included an aqueous (juice or pressed solubles) and/or methanol-soluble fraction.
According to the results of differentiation, green beans and tomato extracts inhibited the platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner.
However, green beans and tomato extracts showed a lesser effect compared to the methanolic extracts of grapes on prolonged prothrombin time (PT), and diluted prothrombin time (dPT).
Moreover, extracts of raspberry are more effective in prolonged activated partial thromboplastin time (APTT), and fibrinolytic activity compared to the green beans extracts.
Taken altogether, green beans used combined with tomato may be considered a remedy for the prevention of cardiovascular diseases, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables by Torres-Urrutia C1, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I. (PubMed)
(2) Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion by Norman J. Temple (PMC)
Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle.
Depending on the types of blood vessel damage or blocked, and heart muscle damage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart or a stroke caused by reducing oxygen supply to the brain cells.
Heart disease is a class of conditions associated with blood vessels and heart muscle that affect heart functioning, including coronary artery disease; heart rhythm problems (arrhythmias); and heart defects.
Coronary artery disease is a condition in most cases associated with an inflammatory cholesterol-containing plaque in the arteries.
A stroke can be caused by reduced blood flow or small blood vessel bleeding, leading to the death of neurons that affect parts of the brain's functioning.
Heart failure, a major health problem associated with the reduced function of the heart affects more than 6.5 million Americans, a leading cause of hospitalization in people older than age 65.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.
Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.
There are many prevalent factors associated with cardiovascular disease including family history, age ethnicity, gender, and medical conditions such as cholesterol high blood pressure, and diabetes.
Some researchers suggested overconsumption of carbohydrates over the long term may be one major condition that causes the onset of CVD.
Dr. Norman J. Temple in the examination of the effect of fat, sugar, whole grains in the risk of heart disease wrote, " The evidence linking carbohydrate-rich foods with CHD has been steadily strengthening. Refined carbohydrates, especially sugar-sweetened beverages, increase the risk of CHD. Conversely, whole grains and cereal fiber are protective. An extra one or 2 servings per day of these foods increases or decreases risk by approximately 10% to 20%.".
In other words, the intake of a high amount of carbohydrates is associated with an increased risk of CVD.
Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belongs to the family Fabaceae, and is native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.
In finding a portent compound for the prevention of cardiovascular disease, researchers compared
the antithrombotic activity in participants in central Chile.
The study included extract samples of 19 fruits and 26 vegetables from the local diet. Prepared from each sample included an aqueous (juice or pressed solubles) and/or methanol-soluble fraction.
According to the results of differentiation, green beans and tomato extracts inhibited the platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner.
However, green beans and tomato extracts showed a lesser effect compared to the methanolic extracts of grapes on prolonged prothrombin time (PT), and diluted prothrombin time (dPT).
Moreover, extracts of raspberry are more effective in prolonged activated partial thromboplastin time (APTT), and fibrinolytic activity compared to the green beans extracts.
Taken altogether, green beans used combined with tomato may be considered a remedy for the prevention of cardiovascular diseases, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables by Torres-Urrutia C1, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I. (PubMed)
(2) Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion by Norman J. Temple (PMC)
#Antioxidant #Cucurbitacin B (CuB) Isolated from #Cucumber (Cucumis sativus)Exhibits the Anti-#Melanoma Effects on Vitro, According to Studies
By Kyle J. Norton
Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.
Melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin usually brown or pink color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body besides the kidney and liver.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light colored skin, and personal and family history of skin cancer are associated with the onset of melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, have been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cells.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration, and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to the control.
Furthermore, the injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved in the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additionally, CuB inhibited the proliferation of the cell line and was found to be in a dose-dependent manner, involving the induction of autophagy and exhibiting the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitivity to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine's side effects.
Taken altogether, cucumber processed with a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending the confirmation of a larger sample size and multicenter human study
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.
Melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin usually brown or pink color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body besides the kidney and liver.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light colored skin, and personal and family history of skin cancer are associated with the onset of melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, have been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cells.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration, and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to the control.
Furthermore, the injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved in the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additionally, CuB inhibited the proliferation of the cell line and was found to be in a dose-dependent manner, involving the induction of autophagy and exhibiting the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitivity to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine's side effects.
Taken altogether, cucumber processed with a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending the confirmation of a larger sample size and multicenter human study
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
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