Herbal butterbur may be considered a functional herb in the protection of neurons against changes in the brain and its surrounding blood vessels in the initiated onset of migraine, some scientists suggested.
Migraine headache is one most common headaches defined as the condition of a chronic neurological disorder of moderate to severe headaches, and nausea that usually develop gradually over 5–20 minutes and last for less than 60 minutes.
According to the statistic, the syndrome affects over 15% of the population in the US. If you are a woman your risk of migraine headaches is 2 times higher in compared to men.
Sadly, 1 in 7 people in the world population will develop migraine headaches at some point in their lifetime, And, chronic migraine affects about 2% of the world population.
Some patients during migraine attacks also suffer symptoms of visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch, and smell, and tingling or numbness in the extremities or face.
Believe it or not, 10% of school-age children also suffer from undiagnosed migraine headaches.
Conventional medicine in reduced symptoms of pain during an attack such as Sumatriptan, Rizatriptan,..and Eletriptan may be effective but they may induce certain side effects, including gastrointestinal discomfort, dizziness, drowsiness,... and muscle weakness.
Please make sure that you discuss these side effects with your doctor before taking them.
Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.
The herb has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.
Although the herb is used as a nutritional supplement in the US, scientific studies suggested that it may be used for the prevention of allergic rhinitis and the treatment of migraine.
In a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine, satisfied the International Headache Society criteria, researchers found that by calculating the migraine attack frequency.
ency per month as a percentage change from baseline over a 4-month treatment period
* Migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), compared to 26% of the placebo group.
* The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05).
* In comparison to the baseline, patients, intake of Petasites 75 mg also expressed a significant effect in reduced migraine at 1, 2, and 3 months.
* Mild adverse effects such as gastrointestinal events, predominantly burping. were also reported.
These results suggest that butterbur Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine.
Furthermore, in the review to confirm the strength of evidence of effectiveness for Petasites hybridus in treating prophylaxis of migraine by searching several databases and other sources to identify randomized-controlled trials, the Headache Center Hirslanden in Zürich, Switzerland found 2 trials totaling 293 patients (60 and 233 patients).
According to the selected trials, orally administrated butterbur extract at a higher dose (150 mg) expressed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months compared to the extract at a lower dose (100 mg) and placebo.
Additional differentiation also found some evidence that higher than the recommended dose may be more effective in treating prophylaxis of migraine.
More profoundly, in the study of 60 patients who received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks, researchers found that
* Oral injection of the capsules Petadolex reduces the frequency of migraine attacks decreased by a maximum of 60 percent compared to the baseline.
* No adverse events were reported. Petasites were exceptionally well tolerated.
Taking all together, herbal butterbur extract may be considered a therapeutic treatment in acute and chronic migraine headaches, however, the exact dose should only be prescribed by an herbalist.
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Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
References
(1) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine by Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A.(PubMed)
(2) An extract of Petasites hybridus is effective in the prophylaxis of migraine by Grossman W, Schmidramsl H.(PubMed)
(3) Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review by Agosti R, Duke RK, Chrubasik JE, Chrubasik S.(PubMed)