By Kyle J. Norton
Breast cancer (malignant breast neoplasm) is a type of irregular cell growth that starts either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk in the breast.
There are also rare cases, where breast cancer starts in other areas of the breast.
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone. The risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
The causes of breast cancer are unknown. Researchers do not know, people with the same health conditions and similar family history, some are more susceptible to the onset of the disease, while others do not.
However, an increase in aging, a history of breast conditions, such as previous breast cancer, breast density, use of hormone estrogen therapy, being overweight and obese, and excessive alcohol consumption are some major risk factors that can elevate the development of breast cancer.
Furthermore, genetic mutation of certain inherited from the parent such as genes BRCA1 and BRCA2 are also the prevalent risk factors of breast cancer. There is an estimation that 33% of women who carry a harmful mutation in PALB2 will develop breast cancer by age 70 years.
According to the article posted by the National Institute of Health, " Several different tests are available. Some tests look for a specific harmful BRCA1 orBRCA2 gene mutation that has already been identified in another family member. Other tests check for all of the known harmful mutations in both genes. Multigene (panel) testing uses next-generation sequencing to look for harmful mutations in many genes that are associated with an increased risk of breast and ovarian cancer, including BRCA1 and BRCA2, at the same time".
If you have a family history of genetic mutation involved in breast cancer, please make sure that you have them checked to rule out the possibility.
Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae.
The fruit has been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
Epidemiological studies strongly agree that the consumption of berry fruits, including strawberries has beneficial effects on human health and reduces the risk of chronic diseases, including breast cancer.
The Indian Institute of Science conducted an experiment to examine whether a methanolic extract of strawberry (MESB) fruits processes anticancer activity in leukemia (CEM) and breast cancer (T47D) cell lines ex vivo and its cancer therapeutic and chemopreventive potential in mice models,
* Mice-bearing breast adenocarcinoma with MESB treated by the extract blocked the proliferation of tumor cells in a time-dependent manner.
* Application of the extract also increases lifespan in the cancer-bearing animal model.
* MESB treatment affected tumor cell proliferation by activating apoptosis and did not result in any side effects
* Finally, MESB treatment also induces the intrinsic pathway of apoptosis by activating p73 in breast cancer cells, caused by the mutation of tumor suppressor gene p53.
These results revealed that strawberry fruits possess both cancer-preventive and therapeutic values.
Additionally, in the study to test for anti-breast cancer activity in extracts of six popularly consumed berries--blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry conducted by the University of California, researchers found that strawberry and other berry extracts exert their ability to inhibit the growth of human breast cancer cell line MCF-7 at concentrations ranging from 25 to 200 micro g/mL.
Moreover, researchers also discovered the apoptosis rate of breast cancer cell killing are increased with increasing concentration of the extract. These findings suggested that strawberry extract may have the potential to kill 100% of breast cancer cells in a dose-dependent manner.
In comparison to other extracts, black raspberry, and strawberry extracts showed the most significant pro-apoptotic effects against breast cell lines.
However, due to the limitation of the above studies, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of strawberry anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Extracts of strawberry fruits induce the intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice, by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
Thursday, 11 May 2023
#Lycopene Inhibits the Onset of Chronic Obstructive Lung Diseases, Researchers Show
By Kyle J. Norton
The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.
According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.
In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.
The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, and smoking are some of the most prevalent factors associated with the onset of the disease.
The most common lung diseases in North America include asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.
Symptoms of lung disease are totally depending on the type of disease.
The most common diseases associated with allergic airway inflammation are
* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
*Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US can be classified into
** Emphysema caused by damage to tissues of the air sacs (alveoli) in the lungs is a type of chronic obstructive pulmonary disease (COPD)associated with a long-term and progressive condition caused of shortness of breath but depending on the stage of lung function.
** Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung-induced symptoms of difficulty breathing.
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of asthma researchers examined the effects of ascorbic acid (AA), carotenoids (lutein, zeaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene), retinol and α-tocopherol levels in Japanese patients with chronic obstructive lung diseases (COPD).
Based on the tested analysis, compared to other phytochemicals, plasma AA level was significantly lower in COPD subjects than that in healthy elderly people.
Levels of plasma lycopene and total carotenoid levels associated with levels of antioxidant enzymes such as GSH content produced by the host were significantly lower in COPD subjects compared to those of healthy elderly people without affecting the redox markers such as GSSG, GSH/GSSG ratio associated with the oxidative stress in the lung tissues.
Lycopene and total carotenoid levels did not lower the marker of the levels of urinary 8-OHdG detected in COPD subjects compared to healthy elderly people.
In other words, increased levels of lycopene and total carotenoid levels in the body may have a strong impact on reducing the risk of COPD
Based on the findings, researchers said, "COPD of Japanese patients may develop partly because of oxidative stress derived from a shortage of antioxidant nutrients, especially of AA and lycopene".
Taken altogether, lycopene found in tomatoes may be considered a remedy for the prevention of COPD, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease, asthma-COPD overlap syndrome, and bronchial asthma by Kodama Y1, Kishimoto Y2, Muramatsu Y3, Tatebe J4, Yamamoto Y5, Hirota N3, Itoigawa Y1, Atsuta R1, Koike K1, Sato T1, Aizawa K5, Takahashi K1, Morita T4, Homma S3, Seyama K1, Ishigami A. (PubMed)
The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.
According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.
In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.
The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, and smoking are some of the most prevalent factors associated with the onset of the disease.
The most common lung diseases in North America include asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.
Symptoms of lung disease are totally depending on the type of disease.
The most common diseases associated with allergic airway inflammation are
* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
*Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US can be classified into
** Emphysema caused by damage to tissues of the air sacs (alveoli) in the lungs is a type of chronic obstructive pulmonary disease (COPD)associated with a long-term and progressive condition caused of shortness of breath but depending on the stage of lung function.
** Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung-induced symptoms of difficulty breathing.
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the treatment of asthma researchers examined the effects of ascorbic acid (AA), carotenoids (lutein, zeaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene), retinol and α-tocopherol levels in Japanese patients with chronic obstructive lung diseases (COPD).
Based on the tested analysis, compared to other phytochemicals, plasma AA level was significantly lower in COPD subjects than that in healthy elderly people.
Levels of plasma lycopene and total carotenoid levels associated with levels of antioxidant enzymes such as GSH content produced by the host were significantly lower in COPD subjects compared to those of healthy elderly people without affecting the redox markers such as GSSG, GSH/GSSG ratio associated with the oxidative stress in the lung tissues.
Lycopene and total carotenoid levels did not lower the marker of the levels of urinary 8-OHdG detected in COPD subjects compared to healthy elderly people.
In other words, increased levels of lycopene and total carotenoid levels in the body may have a strong impact on reducing the risk of COPD
Based on the findings, researchers said, "COPD of Japanese patients may develop partly because of oxidative stress derived from a shortage of antioxidant nutrients, especially of AA and lycopene".
Taken altogether, lycopene found in tomatoes may be considered a remedy for the prevention of COPD, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease, asthma-COPD overlap syndrome, and bronchial asthma by Kodama Y1, Kishimoto Y2, Muramatsu Y3, Tatebe J4, Yamamoto Y5, Hirota N3, Itoigawa Y1, Atsuta R1, Koike K1, Sato T1, Aizawa K5, Takahashi K1, Morita T4, Homma S3, Seyama K1, Ishigami A. (PubMed)
#Herbal #Garlic Reduces the Risk and Treatment of Gastric Cancer Potentially, Researchers Suggest
By Kyle J. Norton
Scientists from various respectable institutions suggested that out of many herbs, garlic may be one of the most powerful whole-food medicine in reducing the risk of gastric cancer due to the effects of phytochemicals.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Stomach or Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
Diallyl disulfide(DADS), an antioxidant found in garlic inhibited the proliferation of several tumor cells by interfering in cell cycle arrest. Administrated garlic induced the reduction of 23% of the live gastric adenocarcinoma cell line(AGS) in the G(2)-M phase, after 400 µM DADS treatment for 48 hours.
Dr. Wang X, the lead author in the animal study said,"... Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo, may be partly due to its antioxidant and immunomodulatory effects"
In fact, the effectiveness of garlic in reduced risk and treatment of gastric cancer probably is due to its antioxidants, such as Diallyl disulfide(DADS) and extract in inhibition of cancer cells through the influence of cell cycle division and negation of proinflammatory pathways.
Some researchers suggested using garlic as chemopreventive therapy, as the experiment showed that garlic scavenges free radicals, and inhibits cell proliferation of tumor growth.
Therefore, people who add an additional portion of garlic into their diet may see the risk of gastric cancer development reduced substantially.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line by Lee JE1, Lee RA, Kim KH, Lee JH. (PubMed)
(2) Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). by Yan JY1, Tian FM, Hu WN, Zhang JH, Cai HF, Li N.(PubMed)
(3) Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. by Wang X1, Jiao F, Wang QW, Wang J, Yang K, Hu RR, Liu HC, Wang HY, Wang YS(PubMed).
(4) Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment by Jiang XY1, Zhu XS1, Xu HY1, Zhao ZX1,2,3, Li SY1, Li SZ3, Cai JH3, Cao JM3(PubMed)
(5) The Mechanism in Gastric Cancer Chemoprevention by Allicin by Luo R, Fang D, Hang H, Tang Z1.(PubMed)
Scientists from various respectable institutions suggested that out of many herbs, garlic may be one of the most powerful whole-food medicine in reducing the risk of gastric cancer due to the effects of phytochemicals.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Stomach or Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
Diallyl disulfide(DADS), an antioxidant found in garlic inhibited the proliferation of several tumor cells by interfering in cell cycle arrest. Administrated garlic induced the reduction of 23% of the live gastric adenocarcinoma cell line(AGS) in the G(2)-M phase, after 400 µM DADS treatment for 48 hours.
Dr. Wang X, the lead author in the animal study said,"... Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo, may be partly due to its antioxidant and immunomodulatory effects"
In fact, the effectiveness of garlic in reduced risk and treatment of gastric cancer probably is due to its antioxidants, such as Diallyl disulfide(DADS) and extract in inhibition of cancer cells through the influence of cell cycle division and negation of proinflammatory pathways.
Some researchers suggested using garlic as chemopreventive therapy, as the experiment showed that garlic scavenges free radicals, and inhibits cell proliferation of tumor growth.
Therefore, people who add an additional portion of garlic into their diet may see the risk of gastric cancer development reduced substantially.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line by Lee JE1, Lee RA, Kim KH, Lee JH. (PubMed)
(2) Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). by Yan JY1, Tian FM, Hu WN, Zhang JH, Cai HF, Li N.(PubMed)
(3) Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. by Wang X1, Jiao F, Wang QW, Wang J, Yang K, Hu RR, Liu HC, Wang HY, Wang YS(PubMed).
(4) Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment by Jiang XY1, Zhu XS1, Xu HY1, Zhao ZX1,2,3, Li SY1, Li SZ3, Cai JH3, Cao JM3(PubMed)
(5) The Mechanism in Gastric Cancer Chemoprevention by Allicin by Luo R, Fang D, Hang H, Tang Z1.(PubMed)
#Healthyfood #Papaya Exhibits Anti-Chronic Inflammatory Diseases Properties, Scientists Say
By Kyle J. Norton
In seeking natural therapy with no side effects, scientists may have found a whole fruit for the prevention and treatment of chronic inflammatory diseases, according to studies.
Inflammation is a natural immune response that protects our body against the invasion of stimuli and foreign pathogens.
During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.
However, the overproduction of inflammatory cytokines not only can induce fever, swelling, and pain in the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.
Chronic inflammatory diseases are the class of conditions involved in low-grade inflammation of the affected tissue or organ. Some researchers suggested that the immune system has evolved over thousands of years to kill off foreign invasive pathogens within a period of time, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.
There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involving the immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.
Certain risk factors such as long-term exposure to irritants, such as industrial chemicals or polluted air, the increase in age, being obese or obesity, low sex hormone production, sleep disorder, and diet.
The Karolinska Universitetssjukhuset Solna study suggested that cigarette smoking is emerging as a strong risk factor in the otherwise unknown etiology of chronic inflammatory diseases. The risk of nicotine smokers showed a substantial increase in the risk of chronic inflammatory diseases compared to ever-nonsmokers.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries
With an aim to investigate the therapeutic potential of fruit and vegetables in the inhibition of inflammation, with no side effects and the whole foods additive and synergistic benefits, researchers at the Universiti Putra Malaysia examined the role of papaya in mediating inflammatory responses.
On cells of healthy individuals, according to the flow cytometry methods, injection of the fruit significantly inhibited the overexpression of IFN-γ(+), a cytokine that is critical for innate and adaptive immunity and CD4(+), in the activation of the cells of the innate immune system, B-lymphocytes, cytotoxic T cells.
The application also showed to increase the levels of anti-inflammatory cytokines which play a critical role in reducing the risk of inflammation.
These results suggested that papaya suppressed the pro-inflammatory cytokines through its anti-inflammatory response mediated through Tregs, a specialized subpopulation of T cells that act to suppress the immune response.
In other words, papaya modulates the systematic immune response through a set of mechanisms in the acute phase of infection.
Furthermore, in finding a natural ingredient or whole food for the treatment of patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers evaluated the effect of mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya.
The application of mangiferin (MF) was found epidemiologically to attenuate cecal ligation and puncture-induced mortality and acute lung injury (ALI), by reducing systemic and pulmonary inflammatory responses.
In Sepsis patients, pretreatment with MF inhibits sepsis-activated mitogen-activated protein kinases which play a critical role in directing cellular responses to a diverse array of stimuli, and nuclear factor kappa-light-chain-enhancer of activated B cells signaling (NF-κB) associated with the production of pro-inflammatory cytokine for cell survival.
These actions indicated that pretreatment with MF inhibits the production of proinflammatory mediators associated with immune responses.
In the tested animal, MF dose-dependently exhibited the expression and activity of heme oxygenase (HO)-1, a gene that plays a critical role in the prevention of vascular inflammation. in the lung of septic mice.
Dr.Gong X, the lead scientist said, 'MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators", after taking into account co and confounders.
Interestingly, in the evaluated fermented papaya preparation, a functional food supplement, researchers at the Touro College of Pharmacy also found that the fermentation exhibited anti-inflammatory, antioxidant, and immunostimulatory (at the level of the mucous membrane), through a set of bioactive compounds found in the fruit.
Taken altogether, papaya may be considered a functional fruit for the prevention and treatment of diseases associated with chronic inflammation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco, and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papaya increases regulatory T cells and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
(3) Applications and bioefficacy of the functional food supplement fermented papaya preparation by Aruoma OI1, Hayashi Y, Marotta F, Mantello P, Rachmilewitz E, Montagnier L.(PubMed)
(4) Smoking, use of moist snuff, and risk of chronic inflammatory diseases by Carlens C1, Hergens MP, Grunewald J, Ekbom A, Eklund A, Höglund CO, Askling J.(PubMed)
In seeking natural therapy with no side effects, scientists may have found a whole fruit for the prevention and treatment of chronic inflammatory diseases, according to studies.
Inflammation is a natural immune response that protects our body against the invasion of stimuli and foreign pathogens.
During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.
However, the overproduction of inflammatory cytokines not only can induce fever, swelling, and pain in the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.
Chronic inflammatory diseases are the class of conditions involved in low-grade inflammation of the affected tissue or organ. Some researchers suggested that the immune system has evolved over thousands of years to kill off foreign invasive pathogens within a period of time, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.
There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involving the immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.
Certain risk factors such as long-term exposure to irritants, such as industrial chemicals or polluted air, the increase in age, being obese or obesity, low sex hormone production, sleep disorder, and diet.
The Karolinska Universitetssjukhuset Solna study suggested that cigarette smoking is emerging as a strong risk factor in the otherwise unknown etiology of chronic inflammatory diseases. The risk of nicotine smokers showed a substantial increase in the risk of chronic inflammatory diseases compared to ever-nonsmokers.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries
With an aim to investigate the therapeutic potential of fruit and vegetables in the inhibition of inflammation, with no side effects and the whole foods additive and synergistic benefits, researchers at the Universiti Putra Malaysia examined the role of papaya in mediating inflammatory responses.
On cells of healthy individuals, according to the flow cytometry methods, injection of the fruit significantly inhibited the overexpression of IFN-γ(+), a cytokine that is critical for innate and adaptive immunity and CD4(+), in the activation of the cells of the innate immune system, B-lymphocytes, cytotoxic T cells.
The application also showed to increase the levels of anti-inflammatory cytokines which play a critical role in reducing the risk of inflammation.
These results suggested that papaya suppressed the pro-inflammatory cytokines through its anti-inflammatory response mediated through Tregs, a specialized subpopulation of T cells that act to suppress the immune response.
In other words, papaya modulates the systematic immune response through a set of mechanisms in the acute phase of infection.
Furthermore, in finding a natural ingredient or whole food for the treatment of patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers evaluated the effect of mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya.
The application of mangiferin (MF) was found epidemiologically to attenuate cecal ligation and puncture-induced mortality and acute lung injury (ALI), by reducing systemic and pulmonary inflammatory responses.
In Sepsis patients, pretreatment with MF inhibits sepsis-activated mitogen-activated protein kinases which play a critical role in directing cellular responses to a diverse array of stimuli, and nuclear factor kappa-light-chain-enhancer of activated B cells signaling (NF-κB) associated with the production of pro-inflammatory cytokine for cell survival.
These actions indicated that pretreatment with MF inhibits the production of proinflammatory mediators associated with immune responses.
In the tested animal, MF dose-dependently exhibited the expression and activity of heme oxygenase (HO)-1, a gene that plays a critical role in the prevention of vascular inflammation. in the lung of septic mice.
Dr.Gong X, the lead scientist said, 'MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators", after taking into account co and confounders.
Interestingly, in the evaluated fermented papaya preparation, a functional food supplement, researchers at the Touro College of Pharmacy also found that the fermentation exhibited anti-inflammatory, antioxidant, and immunostimulatory (at the level of the mucous membrane), through a set of bioactive compounds found in the fruit.
Taken altogether, papaya may be considered a functional fruit for the prevention and treatment of diseases associated with chronic inflammation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco, and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papaya increases regulatory T cells and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
(3) Applications and bioefficacy of the functional food supplement fermented papaya preparation by Aruoma OI1, Hayashi Y, Marotta F, Mantello P, Rachmilewitz E, Montagnier L.(PubMed)
(4) Smoking, use of moist snuff, and risk of chronic inflammatory diseases by Carlens C1, Hergens MP, Grunewald J, Ekbom A, Eklund A, Höglund CO, Askling J.(PubMed)
Wednesday, 10 May 2023
#Healthyfood #Ginger, the Potential Anti-#Cancer Functional Food, Scientists Say
By Kyle J. Norton
Scientists may have found a pungent kitchen spice that processes the potency for the prevention and treatment of cancers, some studies found.
Cancer is a class of chronic illness characterized by cell growth disorderly and uncontrollably in some tissue and organs in the body.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.
Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.
At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.
The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, and family history of cancer are some most common prevalent risk factors of cancer.
Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.
According to the statistic, approximately 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.
Lung, colorectal, breast, and prostate cancer account for about half of all cancer diagnoses and deaths.
About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine obesity and cancer risk.
At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".
These results clearly suggested the risk of cancer is elevated in the obese and overweight population compared to healthy-weight individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural whole food for the treatment of cancer with no side effects, researchers looked into ginger's antiemetic and anticancer activities.
By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-shogaol can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".
Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibiting anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from ginger.
The application of ligands from ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.
These results suggested that ligands on ginger-derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.
Taken together, ginger-processed ligands on ginger-derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Scientists may have found a pungent kitchen spice that processes the potency for the prevention and treatment of cancers, some studies found.
Cancer is a class of chronic illness characterized by cell growth disorderly and uncontrollably in some tissue and organs in the body.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.
Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.
At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.
The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, and family history of cancer are some most common prevalent risk factors of cancer.
Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.
According to the statistic, approximately 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.
Lung, colorectal, breast, and prostate cancer account for about half of all cancer diagnoses and deaths.
About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine obesity and cancer risk.
At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".
These results clearly suggested the risk of cancer is elevated in the obese and overweight population compared to healthy-weight individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural whole food for the treatment of cancer with no side effects, researchers looked into ginger's antiemetic and anticancer activities.
By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-shogaol can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".
Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibiting anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from ginger.
The application of ligands from ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.
These results suggested that ligands on ginger-derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.
Taken together, ginger-processed ligands on ginger-derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)#Healthyveggie #Cabbage Kills Endometrial Cancer Cells in Vivo, Researchers Say
By Kyle J. Norton
The endometrium is the inner lining of the mammalian uterus and is very susceptible to hormone change, particularly in the menstrual cycle.Endometrial cancer is a chronic condition characterized by the irregular cell in the tissue of the endometrium.
It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
Most cases of endometrial cancer start on the cells on the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.
Endometrial cancer has metastasized to the rectum, bladder, pelvic and para-aortic lymph nodes and vagina.
The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity, and the use of hormone therapy are some of the major prevalent risk factors associated with endometrial cancer.
Some researchers indicated that hormonal changes in women's bodies, such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic.
In the US, endometrial cancer is the most common cancer of the female reproductive organs. Every year, approximately About 63,000 new cases of uterus cancer are diagnosed, causing the death of 11,000 women.
The 5-year survival rates for white and black women with the disease are 84% and 62% respectively.
At the invasive stage, the survival rate is 16%.
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In findings of natural cancer treatment, researchers examined the effects of 3,3'-Diindolylmethane (DIM), a major in vivo product of indole-3-carbinol (I3C), is a promising anticancer agent derived from vegetables of the Brassica genus including cabbage on the endometrial cancer cell line.
According to the results of the tested analysis,* DIM induced cytotoxic activity by increasing the level of TGF-alpha transcripts by approximately 4-fold within 24 h of indole treatment in the tested cancer cells.
* DIM also induced a 4-fold increase in the activity of the estrogen response marker, alkaline phosphatase (AP), the cancer markers.
In other words, DIM increased the maximum stimulatory effect of estrogen on the TGF-alpha expression to induce cancer cell death.
* DIM alone treatment stimulated levels of secreted TGF-alpha protein by >10-fold. More precisely, the elevated addition of TGF-alpha inhibited the growth of Ishikawa cells, whereas incubation with a TGF-alpha antibody partially reversed the growth-inhibitory effects of DIM.
Based on the results, researchers wrote, " ligand-independent estrogen receptor agonist activity of DIM, and uncover an essential role for the stimulation in TGF-alpha expression and the TGF-alpha activated signal transduction pathway in the potent cytostatic effects of DIM in endometrial cancer cells".
Taken altogether, cabbage may be considered a functional food for the treatment of endometrial cancer pending the confirmation of the large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for a Shorty award over the last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression by Leong H1, Firestone GL, Bjeldanes LF. (PubMed)
Herbal #Bilberry in the Risk of Neuro-Toxicity
By Kyle J. Norton
Neuro-toxicity is a condition of brain damage caused by exposure to toxic substances.
The toxic condition was found to reduce the brain function in transmitting and processing signals to other parts of the nervous system.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
According to the statistics provided by the University of Ibadan, in the United States, for instance, out of 63 million youths under 18 years of age, about 10% have diagnosable neurobehavioural problems with only 20% receiving therapy and the magnitude affected by neurotoxicity is unknown.
The University continued, "The adverse effects of neurotoxicity are among the most feared ill health in humans because they adversely affect the quality of life", and "Undoubtedly, the magnitude and potential severity of neurotoxicity problems make it imperative to invest in resources required to strengthen the basis for preventive intervention, the forerunner of which is the development of biomarkers for neurotoxicity at the individual and population levels".
In other words, out of millions of people who have neurobehavioural problems, researchers do not know how many of them are actually caused by toxicity.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
In the analysis of natural compounds with neuroprotective effects in patients with diabetes, researchers examined the antioxidants richly present in bilberry fruits' effects on diabetes-related brain dysfunctions.
The study included the differentiation of the expression patterns of αCaMKII in hippocampal neurons from non-diabetic, diabetic, and diabetic rats fed with an extract of bilberry fruit.
Where Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) plays a significant role in cognitive processes.
Diabetic rat's hippocampal neurons immunoreactive (ir) to αCaMKII were swollen and the lengths of the neuronal fibers were reduced compared to the significantly longer αCaMKII-positive nerve fibers in diabetic rats fed with bilberry fruit.
Injection of bilberry fruit also induced significant changes in the average larger diameter of αCaMKII-ir hippocampal neurons.
The results suggested that bilberry fruits exerted a neuroprotective effect on hippocampal neurons in diabetes through its antioxidants activity.
Furthermore, in order to find more information about the bilberry effect on the brain, researchers examined it's anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) neuroprotective effect against retinal damage in vitro and in vivo.
In RGC cultures, VMA and all three anthocyanidins protected the brain against SIN-1 (chloride) toxicity and inhibited lipid peroxidation in mouse forebrain homogenates through the antioxidant property and NMDA-induced morphological retinal damage by allowing high levels of calcium ions (Ca2+) to enter the cells.
Moreover, VMA and all three anthocyanidins also protected the retinal damage by increasing the TUNEL-positive cells in the ganglion cell layer.
Dr. Matsunaga N, the lead scientist said, "VMA and its anthocyanidins have neuroprotective effects (exerted at least in part via an anti-oxidation mechanism) in these in vitro and in vivo models of retinal diseases".
Taken altogether, bilberry may be considered a functional food for the prevention and treatment of neurological diseases associated with neurotoxicity, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
(3) Environmental Chemicals and Human Neurotoxicity: Magnitude, Prognosis, and Markers by Anetor J. I. 1, Anetor G.O. 2, Iyanda AA1, Adeniyi FAA. (the University of Ibadan)
Neuro-toxicity is a condition of brain damage caused by exposure to toxic substances.
The toxic condition was found to reduce the brain function in transmitting and processing signals to other parts of the nervous system.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
According to the statistics provided by the University of Ibadan, in the United States, for instance, out of 63 million youths under 18 years of age, about 10% have diagnosable neurobehavioural problems with only 20% receiving therapy and the magnitude affected by neurotoxicity is unknown.
The University continued, "The adverse effects of neurotoxicity are among the most feared ill health in humans because they adversely affect the quality of life", and "Undoubtedly, the magnitude and potential severity of neurotoxicity problems make it imperative to invest in resources required to strengthen the basis for preventive intervention, the forerunner of which is the development of biomarkers for neurotoxicity at the individual and population levels".
In other words, out of millions of people who have neurobehavioural problems, researchers do not know how many of them are actually caused by toxicity.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
In the analysis of natural compounds with neuroprotective effects in patients with diabetes, researchers examined the antioxidants richly present in bilberry fruits' effects on diabetes-related brain dysfunctions.
The study included the differentiation of the expression patterns of αCaMKII in hippocampal neurons from non-diabetic, diabetic, and diabetic rats fed with an extract of bilberry fruit.
Where Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) plays a significant role in cognitive processes.
Diabetic rat's hippocampal neurons immunoreactive (ir) to αCaMKII were swollen and the lengths of the neuronal fibers were reduced compared to the significantly longer αCaMKII-positive nerve fibers in diabetic rats fed with bilberry fruit.
Injection of bilberry fruit also induced significant changes in the average larger diameter of αCaMKII-ir hippocampal neurons.
The results suggested that bilberry fruits exerted a neuroprotective effect on hippocampal neurons in diabetes through its antioxidants activity.
Furthermore, in order to find more information about the bilberry effect on the brain, researchers examined it's anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) neuroprotective effect against retinal damage in vitro and in vivo.
In RGC cultures, VMA and all three anthocyanidins protected the brain against SIN-1 (chloride) toxicity and inhibited lipid peroxidation in mouse forebrain homogenates through the antioxidant property and NMDA-induced morphological retinal damage by allowing high levels of calcium ions (Ca2+) to enter the cells.
Moreover, VMA and all three anthocyanidins also protected the retinal damage by increasing the TUNEL-positive cells in the ganglion cell layer.
Dr. Matsunaga N, the lead scientist said, "VMA and its anthocyanidins have neuroprotective effects (exerted at least in part via an anti-oxidation mechanism) in these in vitro and in vivo models of retinal diseases".
Taken altogether, bilberry may be considered a functional food for the prevention and treatment of neurological diseases associated with neurotoxicity, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
(3) Environmental Chemicals and Human Neurotoxicity: Magnitude, Prognosis, and Markers by Anetor J. I. 1, Anetor G.O. 2, Iyanda AA1, Adeniyi FAA. (the University of Ibadan)
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