#Healthyfood #Avocado in the Promotes of Skin Health, Researchers Find

By Kyle J. Norton

Researchers may have found a whole fruit for the promotion of skin health with no side effects, according to studies.

Skin, a large organ of the body protects our tissue and organs against the invasion of pathogens and fluid loss.

There are many causes of skin damage. Sun exposure is the most common cause of skin damage. Other causes of skin damage include smoking cigarettes, drinking too much alcohol, extreme temperatures, and exposure to toxic chemicals and pollutants in the air outside.

Some researchers suggested that free radicals bombard our bodies daily and are also associated with skin damage in the modern world.

Free radicals are unstable molecules with the unpaired electron on the outer ring. In order for them to become balanced, free radical either donates or intercept an electron from another stable molecule, leading to a chain reaction that can not be stopped until the outer ring election is paired or inhibited by an antioxidant.

In fact, free radical formation occurs continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions, they can be generated by our bodies such as the process of metabolism and exogenous sources such as pollution, alcohol, and tobacco smoke.

Free radicals can affect our skin in different ways, including the alternation of the DNA, damage of lipid membranes, and collagen structures, and inducing photoaging and cancer.


Dr. Borut Poljšak, in the study "Free Radicals and Extrinsic Skin Aging," wrote, "Extrinsic skin damage develops due to several factors: ionizing radiation, severe physical and psychological stress, alcohol intake, poor nutrition, overeating, environmental pollution, and exposure to UV radiation (UVR)". and

"The only protection of our skin is in its endogenous protection (melanin and enzymatic antioxidants) and antioxidants we consume from the food (vitamin A, C, E, etc.)".

These results suggested that although free radicals can induce the early onset of skin damage and aging, providing our body with enough antioxidants from food sources is the best way to counter the process.


Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

In finding a natural ingredient or essential oil that has a potential effect on skin health without inducing any side effects, researchers explored the effects of various avocado oils on collagen metabolism.

In skin rats fed diets containing 10% (w/w) of the tested oils, researchers found the akin protective effects were totally dependent on the types of avocado oil.

Rats fed the unrefined avocado oil extracted with hexane from the intact fruit, including unsaponifiable or avocado seed oil, showed a significant increase in soluble collagen content in the skin, though total collagen content was not affected.


The increased soluble collagen content was attributed to the inhibition of lysyl oxidase activity whose increment is associated with the oxidative stress induced by chronic exposure to skin harmful substances.

The active factor which protects skin health was found to be present in the unrefined avocado oil and probably originated from the avocado seed, observed by the collagen metabolism which is affected only by fractions containing lipids fraction from the seed.

In order to illustrate the effects of avocado oil on skin health, researchers evaluated the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natural, on incisional, and excisional cutaneous wound models in Wistar rats.

On the 14 days of application on the wound, 50% SSFAO or avocado oil demonstrate a significant increase in percentage wound contraction and reepithelialization, compared to the petroleum jelly control.

The treatment group also displayed an increase in anti-inflammatory activity, density of collagen, and tensile strength, compared to control groups.


This efficacy of the 50% SSFAO or avocado oil was attributed to the contents of the bioactive compounds, oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%).

Dr. de Oliveira AP, the lead scientist wrote in the final report, "When used in natural or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process".

In skin exposure to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, reduced significantly UV-induced cellular damage, through increasing cell viability, decreased the secretion of IL-6, a pro-inflammatory cytokine, and PGE(2) in mediated the inflammation process.

Taken altogether, avocado processed abundantly bioactive compounds may be considered a functional food for the promotion of skin health without inducing any side effects


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(4) Free Radicals and Extrinsic Skin Aging by Borut Poljšak 1 and Raja Dahmane. (PMC)

#Honey Inhibits the Risk of #BreastCancer, Studies Suggest

By Kyle J. Norton

Scientists may have found a sweet whole food which processes a strong effect in the prevention and treatment of breast cancer, according to some studies.
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

In the early stage, most patients with breast cancer may experience lumps on the breast or surrounding the breast.

However, breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness, and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.

At the later stage, after colonizing most parts of the breast, the breast cancer cells may travel a distance far the way to infect other healthy cells and tissue.

In Canada, according to the statistic, 11% of women will develop breast cancer by the time they reach 90 years of age.

Just about 20% of breast cancers in Canada are diagnosed in women under 50, while almost 30% are diagnosed in women over 70 years of age.


These results suggested that the most common risk factor to fuel the onset of breast cancer is the increase in age.

The concern of the increasing number of studies indicates that the strength and even direction the association between breast cancer and established risk factors differ according to the woman's age when she develops the disease, Dr. Tryggvadóttir L, the lead scientist. according to the result of the study of a cohort of 80.219 women attending population-based cervical and breast cancer screening in Iceland, 1120 cases were identified, aged 26-90 years at diagnosis, and 10,537 controls, individually matched to the cases on birth year and age when attending wrote at the final report, "age at diagnosis should be taken into account when studying the effects of breast cancer risk factors".

Sadly to let you know that 60% of women who carry the genetic mutation of gene BRCA1 and 2 have breast cancer developed before the age of 70.

Other risk factors associated with the onset of breast cancer are reproductive history having a dense breast, personal and family history, previous intake of the drug diethylstilbestrol (DES), previous radiotherapy.

Regardless of all risk factors, women's breast self-examinations are still the most important methods to have breast cancer diagnosed early and increase the years of survival.

According to worldwide statistics, the 5 survival rate of the early stage of breast cancer is 100%.


Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener many people.

In finding natural compounds in cancer therapy, researchers at the United Arab Emirates University conducted an experiment to test the underlying mechanism and molecular targets of manuka honey (MH) on proliferation, invasiveness, and angiogenic potential were investigated using two human breast cancer cell lines, the triple-negative MDA-MB-231 cells and estrogen receptor-positive MCF-7 cells, and the non-neoplastic breast epithelial MCF-10A cell line.

Infection of MH at concentrations of 0.3-1.25% (w/v) induced a dose-dependent inhibition of the proliferation of MDA-MB-231 and MCF-7, but not MCF-10A, cells.

At higher concentrations (>2.5%), MH was found to be generally deleterious to the growth of all three cell lines.

MH induced apoptosis of MDA-MB-231 cells through activation of proteins associated with the cell death programming and cancer cells apoptosis correlated with a loss of proteins associated with cancer cell proliferation.

Furthermore, low concentrations of MH (0.03-1.25% w/v) induced a rapid reduction in tyrosine-phosphorylated STAT3 (pY-STAT3) involved in cell growth and division in MDA-MB-231 and MCF-7 cells.

The maximum inhibition of pY-STAT3 was observed at 1 h with a loss of >80% and coincided with decreased interleukin-6 (IL-6) production.


These results suggested manuka honey (MH) inhibits breast cancer cell lines through many different mechanisms

A total of 50 nulliparous female Sprague-Dawley rats were grouped as follows: Group 0 (healthy normal rats control), Group 1 (negative control; untreated rats), Groups 2, 3, and 4 received daily doses of 0.2, 1.0, and 2.0 g/kg body weight of TH, respectively. The rats in groups 1, 2, 3, 4 were induced with 80 mg/kg of 1-methyl-1-nitrosourea (MNU) to examine the effects of Tualang honey (TH) against breast cancer.

The TH-treated rats showed a reduction of tumor progression (mean 75.3 days versus 51.5 days) compared to control.

The incidence (mean 76.6% versus 100%); the multiplicity (mean 2.5 versus 4 tumor masses per rat); the size of tumor mass (mean 0.41 cm versus 1.47 cm [p < 0.05]) and the weight of the tumor mass (mean 1.22 g versus 3.23 g; [p < 0.05]) also lower in the TH treated rats compared to control.

The grade of breast cancer is lower (I and II) compared to control (Grade III),

The efficacy of TH treatment in reducing the expression of breast cancer was attributed to the lower anti-apoptotic proteins (E2, ESR1, and Bcl-xL) expression and a higher pro-apoptotic proteins (Apaf-1 and Caspase-9) expression at serum and on the cancer tissue level.


The breast cancer size breast in the TH-treated groups was smaller mean tumor size (≤ 2 cm3) compared to Controls (≤ 8 cm3). The number of cancers developing in TH-treated groups was also significantly lower.

More importantly, an increasing trend of the apoptotic index (AI) was found in TH-treated groups with an increasing dosage of Tualang Honey compared to control.

Taken altogether, adding a portion of honey into a women's diet may have a potential effect in reducing the risk of breast cancer.

And honey may be considered an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells by Aryappalli P1, Al-Qubaisi SS1, Attoub S2, George JA1,3, Arafat K2, Ramadi KB1, Mohamed YA1, Al-Dhaheri MM1, Al-Sbiei A1, Fernandez-Cabezudo MJ3, Al-Ramadi BK. (PubMed)
(2) The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study by Ahmed S1,2, Othman NH. (PubMed)
(3) Inhibitory effects of Tualang Honey on experimental breast cancer in rats: a preliminary study by Kadir EA1, Sulaiman SA, Yahya NK, Othman NH. (PubMed)
(4) Breast cancer risk factors and age at diagnosis: an Icelandic cohort study by Tryggvadóttir L1, Tulinius H, Eyfjord JE, Sigurvinsson T. (PubMed)

#Herbal #Chastetreeberry Processes Anti-Hyperprolactinemia Potentially Associated with Premenstrual Syndrome, Researchers Suggest

 By Kyle J. Norton

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

Hyperprolactinemia is a condition of elevated serum of prolactin which is the hormone in regulated
breast development and lactation during puberty and pregnancy, respectively.

High levels of prolactin have been found to associate with elevated symptoms in premenstrual syndrome women. Administration of herbal Chaste tree berries may ease the symptoms and treatment of mild and serve cases of PMS.

According to the Second Military Medical University, in the induced hyperprolactinemia SD rat models by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d), injection of casticin, a flavonoid isolated from Vitex rotundifolia in the treatment group, exhibited the reduction of (10, 20, and 40 mg/kg, ip, for 7 d) serum prolactin levels by 33.9%, 54.3%, and 64.7%,.compared untreated control group.

Dr. YE Q, the lead author in the study said, casticin ameliorated the stimulation of pituitary cells with 17β-Estradiol (E2), a female sex hormone in prolactin secretion.

The study also found that casticin at doses of 0.1, 1, and 10 micromol/L, significantly inhibited the prolactin release stimulated by 17β-Estradiol (E2) in a concentration-dependent manner., through regulating the DNA expression of estrogen receptors inactivated sex hormone for the secretion of porcelain.

In the review of pharmacology and clinical indications of the effectiveness of chaste tree berries in PMS women. the University of Göttingen found that

1. The herbal extract consisted of a beneficial influence on most common premenstrual symptoms, indicated by double-blind placebo-controlled studies.

2. Numerous less rigidly controlled studies indicated that AC extracts reduced premenstrual mastodynia by inhibiting levels of prolactin through suppressed stimulation of the mammary gland in response to stressful situations and during deep sleep phases.

Dr. Wuttke W said" The search for the chemical identity of the dopaminergic compounds resulted in the isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects" and "dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome".

Taking together, Chaste tree berries may be beneficial in reducing symptoms for women with PMS during the menstrual cycle, especially in hyperprolactinemia-induced premenstrual breast pain and discomfort.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Sources
(1) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP. (PubMed)

(2) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)

#Healthyfood #Strawberries Gobble Up #BreastCancer Cells in Vivo and Vitro, Scientists Say

By Kyle J. Norton

Breast cancer (malignant breast neoplasm) is a type of irregular cell growth that starts either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk in the breast.
There are also rare cases, where breast cancer starts in other areas of the breast.

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone. The risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

The causes of breast cancer are unknown. Researchers do not know, people with the same health conditions and similar family history, some are more susceptible to the onset of the disease, while others do not.

However, an increase in aging, a history of breast conditions, such as previous breast cancer, breast density, use of hormone estrogen therapy, being overweight and obese, and excessive alcohol consumption are some major risk factors that can elevate the development of breast cancer.

Furthermore, genetic mutation of certain inherited from the parent such as genes BRCA1 and BRCA2 are also the prevalent risk factors of breast cancer. There is an estimation that 33% of women who carry a harmful mutation in PALB2 will develop breast cancer by age 70 years.

According to the article posted by the National Institute of Health, " Several different tests are available. Some tests look for a specific harmful BRCA1 orBRCA2 gene mutation that has already been identified in another family member. Other tests check for all of the known harmful mutations in both genes. Multigene (panel) testing uses next-generation sequencing to look for harmful mutations in many genes that are associated with an increased risk of breast and ovarian cancer, including BRCA1 and BRCA2, at the same time".


If you have a family history of genetic mutation involved in breast cancer, please make sure that you have them checked to rule out the possibility.

Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae.

The fruit has been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Epidemiological studies strongly agree that the consumption of berry fruits, including strawberries has beneficial effects on human health and reduces the risk of chronic diseases, including breast cancer.

The Indian Institute of Science conducted an experiment to examine whether a methanolic extract of strawberry (MESB) fruits processes anticancer activity in leukemia (CEM) and breast cancer (T47D) cell lines ex vivo and its cancer therapeutic and chemopreventive potential in mice models,
* Mice-bearing breast adenocarcinoma with MESB treated by the extract blocked the proliferation of tumor cells in a time-dependent manner.

* Application of the extract also increases lifespan in the cancer-bearing animal model.

* MESB treatment affected tumor cell proliferation by activating apoptosis and did not result in any side effects

* Finally, MESB treatment also induces the intrinsic pathway of apoptosis by activating p73 in breast cancer cells, caused by the mutation of tumor suppressor gene p53.

These results revealed that strawberry fruits possess both cancer-preventive and therapeutic values.

Additionally, in the study to test for anti-breast cancer activity in extracts of six popularly consumed berries--blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry conducted by the University of California, researchers found that strawberry and other berry extracts exert their ability to inhibit the growth of human breast cancer cell line MCF-7 at concentrations ranging from 25 to 200 micro g/mL.

Moreover, researchers also discovered the apoptosis rate of breast cancer cell killing are increased with increasing concentration of the extract. These findings suggested that strawberry extract may have the potential to kill 100% of breast cancer cells in a dose-dependent manner.

In comparison to other extracts, black raspberry, and strawberry extracts showed the most significant pro-apoptotic effects against breast cell lines.

However, due to the limitation of the above studies, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of strawberry anti-breast cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Extracts of strawberry fruits induce the intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice, by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)

#Lycopene Inhibits the Onset of Chronic Obstructive Lung Diseases, Researchers Show

By Kyle J. Norton

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.
According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.

In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, and smoking are some of the most prevalent factors associated with the onset of the disease.

The most common lung diseases in North America include asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.

Symptoms of lung disease are totally depending on the type of disease.

The most common diseases associated with allergic airway inflammation are
* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.

*Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US can be classified into
** Emphysema caused by damage to tissues of the air sacs (alveoli) in the lungs is a type of chronic obstructive pulmonary disease (COPD)associated with a long-term and progressive condition caused of shortness of breath but depending on the stage of lung function.

** Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung-induced symptoms of difficulty breathing.

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of asthma researchers examined the effects of ascorbic acid (AA), carotenoids (lutein, zeaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene), retinol and α-tocopherol levels in Japanese patients with chronic obstructive lung diseases (COPD).

Based on the tested analysis, compared to other phytochemicals, plasma AA level was significantly lower in COPD subjects than that in healthy elderly people.

Levels of plasma lycopene and total carotenoid levels associated with levels of antioxidant enzymes such as GSH content produced by the host were significantly lower in COPD subjects compared to those of healthy elderly people without affecting the redox markers such as GSSG, GSH/GSSG ratio associated with the oxidative stress in the lung tissues.

Lycopene and total carotenoid levels did not lower the marker of the levels of urinary 8-OHdG detected in COPD subjects compared to healthy elderly people.

In other words, increased levels of lycopene and total carotenoid levels in the body may have a strong impact on reducing the risk of COPD

Based on the findings, researchers said, "COPD of Japanese patients may develop partly because of oxidative stress derived from a shortage of antioxidant nutrients, especially of AA and lycopene".

Taken altogether, lycopene found in tomatoes may be considered a remedy for the prevention of COPD, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease, asthma-COPD overlap syndrome, and bronchial asthma by Kodama Y1, Kishimoto Y2, Muramatsu Y3, Tatebe J4, Yamamoto Y5, Hirota N3, Itoigawa Y1, Atsuta R1, Koike K1, Sato T1, Aizawa K5, Takahashi K1, Morita T4, Homma S3, Seyama K1, Ishigami A. (PubMed)

#Herbal #Garlic Reduces the Risk and Treatment of Gastric Cancer Potentially, Researchers Suggest

By Kyle J. Norton

Scientists from various respectable institutions suggested that out of many herbs, garlic may be one of the most powerful whole-food medicine in reducing the risk of gastric cancer due to the effects of phytochemicals.

Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Stomach or Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

Diallyl disulfide(DADS), an antioxidant found in garlic inhibited the proliferation of several tumor cells by interfering in cell cycle arrest. Administrated garlic induced the reduction of 23% of the live gastric adenocarcinoma cell line(AGS) in the G(2)-M phase, after 400 µM DADS treatment for 48 hours.

Dr. Wang X, the lead author in the animal study said,"... Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo, may be partly due to its antioxidant and immunomodulatory effects"

In fact, the effectiveness of garlic in reduced risk and treatment of gastric cancer probably is due to its antioxidants, such as Diallyl disulfide(DADS) and extract in inhibition of cancer cells through the influence of cell cycle division and negation of proinflammatory pathways.

Some researchers suggested using garlic as chemopreventive therapy, as the experiment showed that garlic scavenges free radicals, and inhibits cell proliferation of tumor growth.

Therefore, people who add an additional portion of garlic into their diet may see the risk of gastric cancer development reduced substantially.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Sources
(1) Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line by Lee JE1, Lee RA, Kim KH, Lee JH. (PubMed)
(2) Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). by Yan JY1, Tian FM, Hu WN, Zhang JH, Cai HF, Li N.(PubMed)
(3) Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. by Wang X1, Jiao F, Wang QW, Wang J, Yang K, Hu RR, Liu HC, Wang HY, Wang YS(PubMed).
(4) Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment by Jiang XY1, Zhu XS1, Xu HY1, Zhao ZX1,2,3, Li SY1, Li SZ3, Cai JH3, Cao JM3(PubMed)
(5) The Mechanism in Gastric Cancer Chemoprevention by Allicin by Luo R, Fang D, Hang H, Tang Z1.(PubMed)

#Healthyfood #Papaya Exhibits Anti-Chronic Inflammatory Diseases Properties, Scientists Say

By Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have found a whole fruit for the prevention and treatment of chronic inflammatory diseases, according to studies.
Inflammation is a natural immune response that protects our body against the invasion of stimuli and foreign pathogens.

During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.

However, the overproduction of inflammatory cytokines not only can induce fever, swelling, and pain in the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.

Chronic inflammatory diseases are the class of conditions involved in low-grade inflammation of the affected tissue or organ. Some researchers suggested that the immune system has evolved over thousands of years to kill off foreign invasive pathogens within a period of time, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.

There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involving the immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.

Certain risk factors such as long-term exposure to irritants, such as industrial chemicals or polluted air, the increase in age, being obese or obesity, low sex hormone production, sleep disorder, and diet.

The Karolinska Universitetssjukhuset Solna study suggested that cigarette smoking is emerging as a strong risk factor in the otherwise unknown etiology of chronic inflammatory diseases. The risk of nicotine smokers showed a substantial increase in the risk of chronic inflammatory diseases compared to ever-nonsmokers.


Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries

With an aim to investigate the therapeutic potential of fruit and vegetables in the inhibition of inflammation, with no side effects and the whole foods additive and synergistic benefits, researchers at the Universiti Putra Malaysia examined the role of papaya in mediating inflammatory responses.


On cells of healthy individuals, according to the flow cytometry methods, injection of the fruit significantly inhibited the overexpression of IFN-γ(+), a cytokine that is critical for innate and adaptive immunity and CD4(+), in the activation of the cells of the innate immune system, B-lymphocytes, cytotoxic T cells.

The application also showed to increase the levels of anti-inflammatory cytokines which play a critical role in reducing the risk of inflammation.

These results suggested that papaya suppressed the pro-inflammatory cytokines through its anti-inflammatory response mediated through Tregs, a specialized subpopulation of T cells that act to suppress the immune response.

In other words, papaya modulates the systematic immune response through a set of mechanisms in the acute phase of infection.

Furthermore, in finding a natural ingredient or whole food for the treatment of patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers evaluated the effect of mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya.


The application of mangiferin (MF) was found epidemiologically to attenuate cecal ligation and puncture-induced mortality and acute lung injury (ALI), by reducing systemic and pulmonary inflammatory responses.

In Sepsis patients, pretreatment with MF inhibits sepsis-activated mitogen-activated protein kinases which play a critical role in directing cellular responses to a diverse array of stimuli, and nuclear factor kappa-light-chain-enhancer of activated B cells signaling (NF-κB) associated with the production of pro-inflammatory cytokine for cell survival.

These actions indicated that pretreatment with MF inhibits the production of proinflammatory mediators associated with immune responses.

In the tested animal, MF dose-dependently exhibited the expression and activity of heme oxygenase (HO)-1, a gene that plays a critical role in the prevention of vascular inflammation. in the lung of septic mice.

Dr.Gong X, the lead scientist said, 'MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators", after taking into account co and confounders.

Interestingly, in the evaluated fermented papaya preparation, a functional food supplement, researchers at the Touro College of Pharmacy also found that the fermentation exhibited anti-inflammatory, antioxidant, and immunostimulatory (at the level of the mucous membrane), through a set of bioactive compounds found in the fruit.

Taken altogether, papaya may be considered a functional fruit for the prevention and treatment of diseases associated with chronic inflammation.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco, and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papaya increases regulatory T cells and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
(3) Applications and bioefficacy of the functional food supplement fermented papaya preparation by Aruoma OI1, Hayashi Y, Marotta F, Mantello P, Rachmilewitz E, Montagnier L.(PubMed)
(4) Smoking, use of moist snuff, and risk of chronic inflammatory diseases by Carlens C1, Hergens MP, Grunewald J, Ekbom A, Eklund A, Höglund CO, Askling J.(PubMed)