Kyle J. Norton
Papaya is found to process anti-acute and chronic inflammatory activity that may be considered an adjunct therapy for the treatment of several chronic diseases, some scientists suggested
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Truly, the main focus of inflammation is to repair damage and injury.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation is also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, and DNA that initiate the development of a number of chronic diseases, such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico several centuries
Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a)
In the reaffirm fruit and vegetables have therapeutic potential as they dampen inflammation with no known side effects, researchers at the Universiti Putra Malaysia launched an evaluation to examine the effect of papaya on the activity of Th1 (IFN-γ(+) CD4(+))/Th2 (IL-4(+)CD4(+)) T cells play in mediating inflammatory responses.
According to the flow cytometry methods. application of papaya exerted a potential effect in down-regulation of IFN-γ(+) CD4(+) (p=0.03, n=13) in the expression of inflammatory markers and up-regulation of IL-4(+) CD4(+) (p=0.04, n=13) T cells, CD3(+) CD4(+) CD25(+) CD127(-) in productiuon of anti inflammatroy sytokines.
Tregs, regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress the immune response in the production of the proteins related to inflammation, which were found after papaya consumption.
In vitro cultures, papaya up-regulates Tregs in male subjects and was significantly associated with suppression of the levels of IL-1β and other inflammatory cytokines.
Dr. Abdullah M., the lead author said, "Papaya consumption may exert an anti-inflammatory response mediated through Tregs and have potential in alleviating inflammatory conditions".
Furthermore, in the reconfirmation of papaya's anti-inflammatory effect in patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers found that pretreatment of mangiferin (MF), a natural glucosyl xanthone found in papaya inhibits sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, the mediators with function in stimulating the production in elevating inflammatory cytokines.
Moreover, MF dose-dependently also up-regulates the expression and activity of heme oxygenase (HO)-1 which plays a critical role in the prevention of vascular inflammation in the lung of septic mice, leading to the elimination of the septic lung injury.
The findings suggested that MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators
Taken together, papaya and its bioactive compound mangiferin (MF) may be an adjunct therapy combined with conventional medicine for the treatment in acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco, and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papaya increases regulatory T cells and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
Monday, 8 May 2023
#Healthyfood #CayennePeppers Process Anti-Metabolic Dysregulation Properties, Researchers Say
Kyle J. Norton
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions. It has been used in traditional medicine to increase metabolism, enhance the circulatory system and stomach and intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, and treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
Metabolic dysregulation refers to abnormal function of the body in the regulation of glucose tolerance, fasting glucose, insulin resistance, and dyslipidemia,...., leading to insulin resistance, type 2 diabetes, and fatty liver disease.
Capsaicin, the major chemical compound used in dietary supplements attenuated metabolic dysregulation in genetically obese diabetic mice by enhancing the expression of modulation of glucose and lipid metabolism involving its receptors.
In obesity-induced inflammation and the development of obesity-related metabolic disorders, cayenne capsaicin suppressed inflammatory responses in inducing glucose intolerance and enhancing fatty acid oxidation in fat tissues, affecting insulin resistance.
The chemical compound involvement in reduced visceral adipose fat, also lowered serum levels of fasting glucose, total cholesterol, and triglycerides, probably through limited fat accumulation in adipose tissues and reduced inflammation, and increased insulin sensitivity.
Dr. Leung FW. said," Clinical evidence supports the role of capsaicin as an anti-obesity agent. Both oral and gastrointestinal exposure to capsaicin increase satiety and reduce energy and fat intake and reduction in visceral abdominal fat" and "Thermogenesis and lipid metabolism-related proteins are altered upon capsaicin treatment in white adipose tissue".
Intake of cayenne for weight loss treatment-induced reduction in visceral abdominal fat may also improve metabolic regulation. Quality doses should only be given by specialists to prevent toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice by Kang JH1, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R.(PubMed)
(2) Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet by Kang JH1, Goto T, Han IS, Kawada T, Kim YM, Yu R.(PubMed)
(3) Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice by Lee GR1, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH, Han IS.(PubMed)
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice by Kang JH1, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R.(PubMed)
(2) Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet by Kang JH1, Goto T, Han IS, Kawada T, Kim YM, Yu R.(PubMed)
(3) Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice by Lee GR1, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH, Han IS.(PubMed)
Sunday, 7 May 2023
#Lycopene Isolated From Tomatoes Inhibits the Onset of Primary Lung Cancer
By Kyle J. Norton
Primary lung cancer is a medical and chronic condition characterized by irregular cell growth in the tissues of the lung.
The lungs are a pair of spongy, air-filled organs located on either side of the chest, with the function of inspiration that takes oxygen from incoming air to the blood and releases carbon dioxide.
In other words, the lung exchanges carbon dioxide from the blood to oxygen.
Furthermore, the lung also filters out a small blood clot, balancing the Ph levels in the body, protecting the body from infection as well as speech.
According to the statistics, in the US, approximately 228,000 people in the US will be diagnosed with lung cancer in 2019 or 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime.
About 60% to 65% of all new lung cancer diagnoses are among people who have never smoked or are former smokers.
Most cases of lung cancer at the early stage are asymptomatic due to the very small size of the tumor. However, at the later stage, the oversize of the tumor not only reduces the lung function and presses on the nearby nerve cells and blood vessels, leading to symptoms of lung cancer, accompanied by general symptoms shared by other types of cancer.
The most common symptoms of lung cancer include a persistent cough, cough-up blood with rust-colored sputum (spit or phlegm) due to the oversize tumor that has pressed on nearby blood vessels, chest pain due to the oversize tumor that has pressed on the nerve cells and shortness of breath. Feeling tired or weak.
The other lung, adrenal gland, bones, brain, and liver are most common in primary lung cancer metastasis.
Some researchers suggested lung cancer in the US may be correlated to the rise of obesity.
Dr. Khemayanto Hidayat, the lead scientist said, "Several meta-analyses of observational studies have been performed to examine the association between general obesity, as measured by body mass index (BMI), and lung cancer. These meta-analyses suggest an inverse relationship between high BMI and this cancer. In contrast to general obesity, abdominal obesity appears to play a role in the development of lung cancer".
And, "greater WC was associated with increased lung cancer risk among never smokers (RR 1.11; 95% CI 1.00, 1.23), former smokers (RR 1.12; 95% CI 1.03, 1.22) and current smokers (RR 1.16; 95% CI 1.08, 1.25). The summary RRs for the highest versus lowest categories of WC and WHR were 1.32 (95% CI 1.13, 1.54; I2 = 18.2%, p-heterogeneity = 0.281) and 1.10 (95% CI 1.00, 1.23; I2 = 24.2%, p-heterogeneity = 0.211), respectively".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural compound for the treatment of lung cancer, researchers in the cancer team at Tufts University investigated the effects of tomato's lycopene against tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced lesions in both lungs in an animal model.
The study included elected male ferrets (6 groups, n = 8-10) who were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, NNK-exposure ferrets showed higher incidences of lung tumors, HCC and steatohepatitis, and elevations in bilirubin and AST levels.
Lycopene supplementation treatment at two doses prevented NNK-induced lung toxicity and inflammation. The expression of levels of CYP2E1 in the liver associated with the metabolism of xenobiotics in the liver was also inhibited by the injection of lycopene.
In other words, lycopene prevented the NNK in the induction of lung and liver damage in the tested animals.
Based on the findings, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Furthermore, in a mouse model associated with colon cancer metastatic to the lungs, Dr. Chattopadhyay A, the lead scientist wrote, "adding 0.06% of Tg6F, but not a control tomato concentrate (EV), to standard mouse chow reduced tumor-associated neutrophils by 94 ± 1.1%, and reduced tumor burden by two-thirds".
Taken altogether, cooked tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer by Chattopadhyay A1, Grijalva V1, Hough G1, Su F2, Mukherjee P1, Farias-Eisner R2, Anantharamaiah GM3, Faull KF4, Hwang LH4, Navab M1, Fogelman AM1, Reddy ST. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies by Khemayanto Hidayat,1 Xuan Du,1 Guochong Chen,2 Minhua Shi,3 and Bimin Shi. (PMC)
Primary lung cancer is a medical and chronic condition characterized by irregular cell growth in the tissues of the lung.
The lungs are a pair of spongy, air-filled organs located on either side of the chest, with the function of inspiration that takes oxygen from incoming air to the blood and releases carbon dioxide.
In other words, the lung exchanges carbon dioxide from the blood to oxygen.
Furthermore, the lung also filters out a small blood clot, balancing the Ph levels in the body, protecting the body from infection as well as speech.
According to the statistics, in the US, approximately 228,000 people in the US will be diagnosed with lung cancer in 2019 or 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime.
About 60% to 65% of all new lung cancer diagnoses are among people who have never smoked or are former smokers.
Most cases of lung cancer at the early stage are asymptomatic due to the very small size of the tumor. However, at the later stage, the oversize of the tumor not only reduces the lung function and presses on the nearby nerve cells and blood vessels, leading to symptoms of lung cancer, accompanied by general symptoms shared by other types of cancer.
The most common symptoms of lung cancer include a persistent cough, cough-up blood with rust-colored sputum (spit or phlegm) due to the oversize tumor that has pressed on nearby blood vessels, chest pain due to the oversize tumor that has pressed on the nerve cells and shortness of breath. Feeling tired or weak.
The other lung, adrenal gland, bones, brain, and liver are most common in primary lung cancer metastasis.
Some researchers suggested lung cancer in the US may be correlated to the rise of obesity.
Dr. Khemayanto Hidayat, the lead scientist said, "Several meta-analyses of observational studies have been performed to examine the association between general obesity, as measured by body mass index (BMI), and lung cancer. These meta-analyses suggest an inverse relationship between high BMI and this cancer. In contrast to general obesity, abdominal obesity appears to play a role in the development of lung cancer".
And, "greater WC was associated with increased lung cancer risk among never smokers (RR 1.11; 95% CI 1.00, 1.23), former smokers (RR 1.12; 95% CI 1.03, 1.22) and current smokers (RR 1.16; 95% CI 1.08, 1.25). The summary RRs for the highest versus lowest categories of WC and WHR were 1.32 (95% CI 1.13, 1.54; I2 = 18.2%, p-heterogeneity = 0.281) and 1.10 (95% CI 1.00, 1.23; I2 = 24.2%, p-heterogeneity = 0.211), respectively".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural compound for the treatment of lung cancer, researchers in the cancer team at Tufts University investigated the effects of tomato's lycopene against tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced lesions in both lungs in an animal model.
The study included elected male ferrets (6 groups, n = 8-10) who were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, NNK-exposure ferrets showed higher incidences of lung tumors, HCC and steatohepatitis, and elevations in bilirubin and AST levels.
Lycopene supplementation treatment at two doses prevented NNK-induced lung toxicity and inflammation. The expression of levels of CYP2E1 in the liver associated with the metabolism of xenobiotics in the liver was also inhibited by the injection of lycopene.
In other words, lycopene prevented the NNK in the induction of lung and liver damage in the tested animals.
Based on the findings, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Furthermore, in a mouse model associated with colon cancer metastatic to the lungs, Dr. Chattopadhyay A, the lead scientist wrote, "adding 0.06% of Tg6F, but not a control tomato concentrate (EV), to standard mouse chow reduced tumor-associated neutrophils by 94 ± 1.1%, and reduced tumor burden by two-thirds".
Taken altogether, cooked tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer by Chattopadhyay A1, Grijalva V1, Hough G1, Su F2, Mukherjee P1, Farias-Eisner R2, Anantharamaiah GM3, Faull KF4, Hwang LH4, Navab M1, Fogelman AM1, Reddy ST. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies by Khemayanto Hidayat,1 Xuan Du,1 Guochong Chen,2 Minhua Shi,3 and Bimin Shi. (PMC)
#Herbal #Dandelion Processes Anti-Inflammatory Activity
By Kyle J. Norton
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the formation of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
However, in people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.
Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, and DNA damage.
Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.
Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin), and other prescription NSAIDs.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of diseases associated with inflammation, scientists examined the mechanisms responsible for the anti-inflammation effects of water extract of T. mongolicum Hand.-Mazz (WETMHM) on lipopolysaccharide (LPS)-induced inflammation in acute lung injury.
Female BALB/c mice selected for the investigation were randomly divided into five groups with 10 mice in each group: (1) control group (saline), (2) LPS group, (3) LPS+dexamethasone (LPS+Dex, 2mg/kg, administered by gavage), (4) LPS+WETMHM (5 g/kg, administered by gavage), (5) LPS+WETMHM (10 g/kg, administered by gavage).
According to the results from the tested analysis, treatment with the WETMHM exhibited a number of mechanisms against LPS-induced inflammation, including the
* Attenuating inflammation cell numbers in the BALF
* Decreasing the protein levels of lung PI3K/Akt/mTOR, and
* Improving the antioxidant activity of SOD.
* Inhibiting MPO activity associated with inflammation
Furthermore, the histological studies also demonstrated that WETMHM substantially inhibited LPS-induced neutrophils in lung tissue.
Based on the results, researchers suggest, " The results indicated that the WETMHM had a protective effect on LPS-induced ALI in mice".
Taken altogether, dandelion may be considered a remedy for the treatment of diseases associated with inflammation, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway by Ma C1, Zhu L1, Wang J1, He H1, Chang X1, Gao J1, Shumin W2, Yan T. (PubMed)
Saturday, 6 May 2023
#Onion, the Potential Anticancer #Health #Food
By Kyle J. Norton
Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.
Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body
*The stage of cancer, most often refers to the size and metastasis of cancer.
** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated in deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer on the surface but have invaded into deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage has invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)
**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.
**Stage III
At this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
**Stage IV
Stage IV is the most advanced stage of cancer as cancerous cells have spread to distant parts of the body
In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.
* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
* Certain traits of cancer cells include
** How cancer cell stimulates their own growth
** How cancer cells resist inhibitory signals that stop their growth
** How cancer cells inhibit programmed cell death signaling.
Some researchers also include the age, health of patients, and how patients responded to previous cancer treatment
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.
Intake of onion is found inversely associated with the risk of onions or garlic and cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.
More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.
Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.
In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.
In esophageal cancer, the intake of raw garlic/onion at least one time per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.
In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.
Taken altogether, onion may be considered a remedy for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)
The Effects of Field Mustard on Apoptotic and Inflammatory Responses
By Kyle J. Norton
The inflammatory response (inflammation) is the reaction of the immune system to target the tissues injured by trauma, toxins, heat, and pathogens.
Inflammation is a natural immune response that protects our body against the invasion of stimuli and foreign pathogens.
During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.
However, the overproduction of inflammatory cytokines not only can induce fever, swelling, and pain in the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.
Chronic inflammatory diseases are the class of conditions involved in low-grade inflammation to affect tissue or organ. Some researchers suggested that the immune system has evolved over thousands of years to kill off foreign invasive pathogens within a period of time, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.
There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involving the immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.
In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.
However, in children, the elderly, and people with a weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.
On finding a potential plant that improves the apoptotic and inflammatory responses, researchers compared the effects of field mustard polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl4).
According to the results of mice that were treated with CCl4 after the oral administration of BRPs (55, 110, and 220 mg/kg) or bidentate (100 mg/kg) for 7 days, BRP pre-treatment significantly decreased the liver toxic markers MDA, ALT, ALP, and AST in the serum, by increasing the levels of SOD and GSH-Px in the liver.
BRPs pretreatment was found to alleviate hepatocyte injury by inhibiting the expression of proinflammatory proteins and pathways, such as TNF-α, IL-1β, and IL-6, and the CCl4 -induced hepatic tissue apoptosis caspase-3.
Based on the findings, researchers said, "This study demonstrated that BRPs exert hepatoprotective effect against the CCl4 -induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway".
Taken altogether, field mustard may be considered a functional food to enhance the apoptotic and inflammatory responses, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Brassica rapa polysaccharides ameliorate CCl4-induced acute liver injury in mice through inhibiting inflammatory apoptotic response and oxidative stress by Qiuyue L1, Yang H2, Wang W3, Li N2, Zou X2, Li Y3, Zhang Y4, Kuang T5, Gang F. (PubMed)
The inflammatory response (inflammation) is the reaction of the immune system to target the tissues injured by trauma, toxins, heat, and pathogens.
Inflammation is a natural immune response that protects our body against the invasion of stimuli and foreign pathogens.
During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.
However, the overproduction of inflammatory cytokines not only can induce fever, swelling, and pain in the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.
Chronic inflammatory diseases are the class of conditions involved in low-grade inflammation to affect tissue or organ. Some researchers suggested that the immune system has evolved over thousands of years to kill off foreign invasive pathogens within a period of time, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.
There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involving the immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.
In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.
However, in children, the elderly, and people with a weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.
On finding a potential plant that improves the apoptotic and inflammatory responses, researchers compared the effects of field mustard polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl4).
According to the results of mice that were treated with CCl4 after the oral administration of BRPs (55, 110, and 220 mg/kg) or bidentate (100 mg/kg) for 7 days, BRP pre-treatment significantly decreased the liver toxic markers MDA, ALT, ALP, and AST in the serum, by increasing the levels of SOD and GSH-Px in the liver.
BRPs pretreatment was found to alleviate hepatocyte injury by inhibiting the expression of proinflammatory proteins and pathways, such as TNF-α, IL-1β, and IL-6, and the CCl4 -induced hepatic tissue apoptosis caspase-3.
Based on the findings, researchers said, "This study demonstrated that BRPs exert hepatoprotective effect against the CCl4 -induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway".
Taken altogether, field mustard may be considered a functional food to enhance the apoptotic and inflammatory responses, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Brassica rapa polysaccharides ameliorate CCl4-induced acute liver injury in mice through inhibiting inflammatory apoptotic response and oxidative stress by Qiuyue L1, Yang H2, Wang W3, Li N2, Zou X2, Li Y3, Zhang Y4, Kuang T5, Gang F. (PubMed)
Friday, 5 May 2023
#Healthyfood #Cranberry Processes Antioxidant Activities
By Kyle J. Norton
Free radicals are highly unstable atoms. Internally, free radicals are produced by our body's cell metabolism. Externally, free radicals can enter our bodies from environmental sources, such as the air we breathe, the food we eat, and the water we drink.
In other words, any chemical compounds or molecules which process an oxygen atom can be free radicals in a chemical reaction with other atoms.
According to epidemiological studies, free radicals are dangerous to human health in excessive amounts. Overexpression of free radicals-induced oxidative stress has been found to damage the lipid, and protein and induce the alternation of healthy cell DNA.
Antioxidants are stable atoms that inhibit oxidation induced by free radicals.
Out of all damages caused by the overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases.
Oxidative stress can either be caused by the overexpression of free radicals or the depletion of antioxidant enzymes produced by the host. The condition has been found to induce cardiovascular disease and type 2 diabetes.
In a healthy person, antioxidants produced by the body are more than enough to counter the expression of free radicals. However, in people with a weakened immune system, the intake of dietary antioxidants regularly can be helpful.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.
Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of cranberry (V. macrocarpon) antioxidant activity.
According to studies, * Vaccinium oxycoccos fruit as a whole group is a valuable source of antioxidants and other biologically active substances.
* European cranberry fruit processed strong antioxidant properties due to being rich in polyphenolic compounds anthocyanins (12.4–207.3 mg/100 g fw), proanthocyanins (1.5–5.3 mg/100 g fw), and flavonols, especially quercetin (0.52–15.4 mg/100 g fw).
* Small cranberry showed a significant antioxidant effect against various biological protection including urinary tract protection (proanthocyanidins), antibacterial and antifungal properties (quercetin, proanthocyanidins, anthocyanins), cardioprotective (proanthocyanidins) and anticancer activities (proanthocyanidins).
Based on the findings, researchers said, "Taking into account various beneficial effects of small cranberries on human health, also in folk medicine, the consumption of these fruits and their products is widely recommended.".
Taken altogether, cranberry may be considered a remedy for enhancing antioxidant activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos) by Tunde Jurikova,1 Sona Skrovankova,2 Jiri Mlcek,2,* Stefan Balla,1 and Lukas Snopek. (PMC)
Free radicals are highly unstable atoms. Internally, free radicals are produced by our body's cell metabolism. Externally, free radicals can enter our bodies from environmental sources, such as the air we breathe, the food we eat, and the water we drink.
In other words, any chemical compounds or molecules which process an oxygen atom can be free radicals in a chemical reaction with other atoms.
According to epidemiological studies, free radicals are dangerous to human health in excessive amounts. Overexpression of free radicals-induced oxidative stress has been found to damage the lipid, and protein and induce the alternation of healthy cell DNA.
Antioxidants are stable atoms that inhibit oxidation induced by free radicals.
Out of all damages caused by the overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases.
Oxidative stress can either be caused by the overexpression of free radicals or the depletion of antioxidant enzymes produced by the host. The condition has been found to induce cardiovascular disease and type 2 diabetes.
In a healthy person, antioxidants produced by the body are more than enough to counter the expression of free radicals. However, in people with a weakened immune system, the intake of dietary antioxidants regularly can be helpful.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.
Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of cranberry (V. macrocarpon) antioxidant activity.
According to studies, * Vaccinium oxycoccos fruit as a whole group is a valuable source of antioxidants and other biologically active substances.
* European cranberry fruit processed strong antioxidant properties due to being rich in polyphenolic compounds anthocyanins (12.4–207.3 mg/100 g fw), proanthocyanins (1.5–5.3 mg/100 g fw), and flavonols, especially quercetin (0.52–15.4 mg/100 g fw).
* Small cranberry showed a significant antioxidant effect against various biological protection including urinary tract protection (proanthocyanidins), antibacterial and antifungal properties (quercetin, proanthocyanidins, anthocyanins), cardioprotective (proanthocyanidins) and anticancer activities (proanthocyanidins).
Based on the findings, researchers said, "Taking into account various beneficial effects of small cranberries on human health, also in folk medicine, the consumption of these fruits and their products is widely recommended.".
Taken altogether, cranberry may be considered a remedy for enhancing antioxidant activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos) by Tunde Jurikova,1 Sona Skrovankova,2 Jiri Mlcek,2,* Stefan Balla,1 and Lukas Snopek. (PMC)
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