#Herbal #Dandelion Processes Anti-Inflammatory Activity

By Kyle J. Norton

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.


Any inflammation that lasts more than 3 months is considered chronic inflammation.

Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the formation of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.

However, in people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.

Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, and DNA damage.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin), and other prescription NSAIDs.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of diseases associated with inflammation, scientists examined the mechanisms responsible for the anti-inflammation effects of water extract of T. mongolicum Hand.-Mazz (WETMHM) on lipopolysaccharide (LPS)-induced inflammation in acute lung injury.

Female BALB/c mice selected for the investigation were randomly divided into five groups with 10 mice in each group: (1) control group (saline), (2) LPS group, (3) LPS+dexamethasone (LPS+Dex, 2mg/kg, administered by gavage), (4) LPS+WETMHM (5 g/kg, administered by gavage), (5) LPS+WETMHM (10 g/kg, administered by gavage).

According to the results from the tested analysis, treatment with the WETMHM exhibited a number of mechanisms against LPS-induced inflammation, including the

* Attenuating inflammation cell numbers in the BALF

* Decreasing the protein levels of lung PI3K/Akt/mTOR, and

* Improving the antioxidant activity of SOD.

* Inhibiting MPO activity associated with inflammation

Furthermore, the histological studies also demonstrated that WETMHM substantially inhibited LPS-induced neutrophils in lung tissue.

Based on the results, researchers suggest, " The results indicated that the WETMHM had a protective effect on LPS-induced ALI in mice".

Taken altogether, dandelion may be considered a remedy for the treatment of diseases associated with inflammation, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway by Ma C1, Zhu L1, Wang J1, He H1, Chang X1, Gao J1, Shumin W2, Yan T. (PubMed)

#Onion, the Potential Anticancer #Health #Food

By Kyle J. Norton

Cancer is a group of medical conditions caused by irregular cell growth in the tissues and organs due to the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.

Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body

*The stage of cancer, most often refers to the size and metastasis of cancer.

** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated in deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer on the surface but have invaded into deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage has invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)

**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.

**Stage III
At this stage, cancerous cells have spread to the tissues immediately surrounding the organ.

**Stage IV
Stage IV is the most advanced stage of cancer as cancerous cells have spread to distant parts of the body

In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.

* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

* Certain traits of cancer cells include
** How cancer cell stimulates their own growth

** How cancer cells resist inhibitory signals that stop their growth

** How cancer cells inhibit programmed cell death signaling.

Some researchers also include the age, health of patients, and how patients responded to previous cancer treatment

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

With an aim to find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.

Intake of onion is found inversely associated with the risk of onions or garlic and cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.


More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.

Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.

In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.

In esophageal cancer, the intake of raw garlic/onion at least one time per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.

In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.

Taken altogether, onion may be considered a remedy for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)

The Effects of Field Mustard on Apoptotic and Inflammatory Responses

By Kyle J. Norton

The inflammatory response (inflammation) is the reaction of the immune system to target the tissues injured by trauma, toxins, heat, and pathogens.

Inflammation is a natural immune response that protects our body against the invasion of stimuli and foreign pathogens.

During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.

However, the overproduction of inflammatory cytokines not only can induce fever, swelling, and pain in the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.

Chronic inflammatory diseases are the class of conditions involved in low-grade inflammation to affect tissue or organ. Some researchers suggested that the immune system has evolved over thousands of years to kill off foreign invasive pathogens within a period of time, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.

There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involving the immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.


In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.

However, in children, the elderly, and people with a weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.


On finding a potential plant that improves the apoptotic and inflammatory responses, researchers compared the effects of field mustard polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl4).

According to the results of mice that were treated with CCl4 after the oral administration of BRPs (55, 110, and 220 mg/kg) or bidentate (100 mg/kg) for 7 days, BRP pre-treatment significantly decreased the liver toxic markers MDA, ALT, ALP, and AST in the serum, by increasing the levels of SOD and GSH-Px in the liver.

BRPs pretreatment was found to alleviate hepatocyte injury by inhibiting the expression of proinflammatory proteins and pathways, such as TNF-α, IL-1β, and IL-6, and the CCl4 -induced hepatic tissue apoptosis caspase-3.

Based on the findings, researchers said, "This study demonstrated that BRPs exert hepatoprotective effect against the CCl4 -induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway".

Taken altogether, field mustard may be considered a functional food to enhance the apoptotic and inflammatory responses, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Brassica rapa polysaccharides ameliorate CCl4-induced acute liver injury in mice through inhibiting inflammatory apoptotic response and oxidative stress by Qiuyue L1, Yang H2, Wang W3, Li N2, Zou X2, Li Y3, Zhang Y4, Kuang T5, Gang F. (PubMed)

#Healthyfood #Cranberry Processes Antioxidant Activities

By Kyle J. Norton

Free radicals are highly unstable atoms. Internally, free radicals are produced by our body's cell metabolism. Externally, free radicals can enter our bodies from environmental sources, such as the air we breathe, the food we eat, and the water we drink.

In other words, any chemical compounds or molecules which process an oxygen atom can be free radicals in a chemical reaction with other atoms.

According to epidemiological studies, free radicals are dangerous to human health in excessive amounts. Overexpression of free radicals-induced oxidative stress has been found to damage the lipid, and protein and induce the alternation of healthy cell DNA.

Antioxidants are stable atoms that inhibit oxidation induced by free radicals.

Out of all damages caused by the overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases.

Oxidative stress can either be caused by the overexpression of free radicals or the depletion of antioxidant enzymes produced by the host. The condition has been found to induce cardiovascular disease and type 2 diabetes.

In a healthy person, antioxidants produced by the body are more than enough to counter the expression of free radicals. However, in people with a weakened immune system, the intake of dietary antioxidants regularly can be helpful.


Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.

Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of cranberry (V. macrocarpon) antioxidant activity.

According to studies, * Vaccinium oxycoccos fruit as a whole group is a valuable source of antioxidants and other biologically active substances.
* European cranberry fruit processed strong antioxidant properties due to being rich in polyphenolic compounds anthocyanins (12.4–207.3 mg/100 g fw), proanthocyanins (1.5–5.3 mg/100 g fw), and flavonols, especially quercetin (0.52–15.4 mg/100 g fw).

* Small cranberry showed a significant antioxidant effect against various biological protection including urinary tract protection (proanthocyanidins), antibacterial and antifungal properties (quercetin, proanthocyanidins, anthocyanins), cardioprotective (proanthocyanidins) and anticancer activities (proanthocyanidins).

Based on the findings, researchers said, "Taking into account various beneficial effects of small cranberries on human health, also in folk medicine, the consumption of these fruits and their products is widely recommended.".

Taken altogether, cranberry may be considered a remedy for enhancing antioxidant activity, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos) by Tunde Jurikova,1 Sona Skrovankova,2 Jiri Mlcek,2,* Stefan Balla,1 and Lukas Snopek. (PMC)

#Alliin Processes Anti Liver Cancer Property, Researchers Say

By Kyle J. Norton

Liver cancer is a medical condition caused by irregular cell growth in the liver tissue.

According to the statistics assessed by cancer experts, in 2019, approximately 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with the disease increased by approximately 3% annually.

The most common preventable causes of liver cancer are excessive alcohol drinking over time, chronic infection by hepatitis B and C, and cirrhosis.

Types of liver cancer include

* Hepatocellular carcinoma, the most common type of liver cancer accounts for 75 percent of all cases.

* Cholangiocarcinoma is a cancer of the bile duct, which is the small, tube-like bile ducts in the liver that carry bile to the gallbladder to help with digestion.

* Liver Angiosarcoma is a rare form of liver cancer that develops quickly and

* Hepatoblastoma also is a rare type of liver cancer found in children, particularly in those under age 3.


The most common symptoms of liver cancer are upper abdominal pain., abdominal swelling, jaundice, and white, chalky stools, accompanied by general symptoms shared by other types of cancer including unintended weight loss, gastrointestinal discomfort, loss of appetite, and persistent fatigue.

If you have experienced some of the aforementioned symptoms with no signs of receding, please make sure that you check with your doctor to rule out the possibility.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the treatment of liver cancer with little or no side effects, researchers in the cancer team at the Institut National de la Recherche Agronomique examined the increasing fertilization of soil resulting in an increased alliin content of the powders on liver cancer animal model.

According to the results, of garlic powders administered to rats for 2 weeks (5% of the diet), administration of the different garlic powders demonstrated a 35-60% reduction in DNA damage induced by N-nitroso dimethylamine (NDMA) in rat liver.

In examining the increased alliin content of the garlic powder, researchers found that the presence of alliin was associated strongly with a proportional decrease in NDMA-induced DNA alteration.

Believe it or not, the increased levels of Alliin in the garlic powder content did not have an additional effect on DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon, compared to the efficacy in the liver.

In other words, garlic powders regardless of the levels of alliin did not modify the genotoxic activity which is the direct-acting carcinogen methyl nitrosourea in the colon.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of liver cancer, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats by Le Bon AM1, Vernevaut MF, Guenot L, Kahane R, Auger J, Arnault I, Haffner T, Siess MH.(PubMed)

#Herbal #Bilberry Inhibits Intestinal Cancer Cells in Vivo

By Kyle J. Norton

Intestinal cancer is a medical condition characterized by irregular cell growth in the tissue of the intestines.

Most cases of intestinal cancer start in the cells on the surface of the inner lining of the internal tissue. At the advanced stage, after penetrating deep layers of the intestines, the cancer cells can travel a distance away from the intestine to infect other healthy tissue and organs, leading to secondary metastasis.

Certain factors such as being overweight or obese, physical inactivity, and certain types of diet. smoking excessive alcohol drinking, family and personal history, and the increase in age are associated with an increased risk of intestinal cancer.

Some researchers suggested that the increased incidence of intestinal cancer in the Western world may be associated with the promotion of a high-fat Western diet over the past many decades.

Dr. Manon D. Schulz, the lead scientist in the investigation of the effects of high-fat diet-mediated dysbiosis that promotes intestinal carcinogenesis suggested, "Several aspects common to a Western lifestyle, including obesity and decreased physical activity, are known risks for gastrointestinal cancers. There is substantial evidence suggesting that diet profoundly affects the composition of the intestinal microbiota. Moreover, there is now unequivocal evidence linking dysbiosis to cancer development".

And, "Undoubtedly various factors contribute to the etiology of intestinal cancer, but there are compelling arguments to include high-fat diet (HFD) and composition of the gut microbiota as key risk factors".

The results strongly suggested that the risk of intestinal cancer can be decreased by changing the diet pattern from the Western diet to a traditional diet with higher fruits and vegetables with a lower intake of red meat and saturated and trans fat and processed foods.

Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.


The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of intestinal carcinogenesis examined the
intestinal carcinogenesis--relationship with tissue anthocyanin levels in an animal model.

Selected Apc(Min) mice ingested C3G or Mirtoselect at 0.03, 0.1, or 0.3% in the diet for 12 weeks, and intestinal adenomas were examined.


Where Mirtoselect, is an anthocyanin mixture from bilberry, and isolated cyanidin-3-glucoside (C3G) is the most abundant anthocyanin in the diet.

C3G and Mirtoselect at the highest doses decreased the adenoma numbers by 45% (p < 0.001) or 30% (p < 0.05), respectively, compared to controls.

According to the intestinal mucosa and urinary assays, anthocyanins were found at the analytical detection limit in the plasma and at quantifiable levels.

More precisely, the total anthocyanin levels in mice on C3G or Mirtoselect were 43 ng and 8.1 microg/g tissue, respectively, in the intestinal mucosa, and 7.2 and 12.3 microg/ml in the urine.
These results suggested that C3G and Mirtoselect in the Apc(Min) mouse processed a chemotherapeutic effect for the treatment of intestinal carcinogenesis.


Moreover, in order to reveal more information about berries' anti-intestinal tumorigenesis, researchers examined the different phenolic profiles of intestinal tumorigenesis in multiple intestinal neoplasia/+ mice.

Mice selected for the study were fed a high-fat AIN93-G diet (Con) or AIN93-G diet containing 10% (w:w) freeze-dried bilberry, lingonberry (LB), or cloudberry (CB) for 10 wk.

All 3 berries significantly inhibited the formation of intestinal adenomas as indicated by a 15-30% reduction in tumor numbers.

According to Western blotting and immunohistochemistry, all 3 berries inhibited the levels of decreased levels of proteins associated with cell cycle division.


Additionally, all 3 berries exerted early protection of the cells in the intestine against the alternation of cell DNA to facilitate the onset of the disease.


The findings strongly suggested the use of berries as chemopreventive components for the treatment of intestinal carcinogenesis.


Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of
intestinal cancer, pending the confirmation of a large sample size and multicenter study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels by Cooke D1, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ, Marczylo TH. (PubMed)
(2) Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinalneoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa by Misikangas M1, Pajari AM, Päivärinta E, Oikarinen SI, Rajakangas J, Marttinen M, Takayama H, Törrönen R, Mutanen M. (PubMed)
(3) High-fat diet-mediated dysbiosis promotes intestinal carcinogenesis independent of obesity by Manon D. Schulz,1,* Çigdem Atay,1,* Jessica Heringer,1,* Franziska K. Romrig,1Sarah Schwitalla,1 Begüm Aydin,2 Paul K. Ziegler,3,4,5 Julia Varga,3,4,5 Wolfgang Reindl,6Claudia Pommerenke,7 Gabriela Salinas-Riester,7 Andreas Böck,8 Carl Alpert,9 Michael Blaut,9Sara C. Polson,10 Lydia Brandl,11 Thomas Kirchner,11 Florian R. Greten,3,4,5Shawn W. Polson,10 and Melek C. Arkan. (PMC)

#Healthyfood #GreenBeans Protect the Liver Against Liver Oxidative Stress Markers

By Kyle J. Norton

Oxidative stress is a condition characterized by overexpression of free radicals in the body.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.

A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radicals readily donate or intercept an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

Antioxidants are stable atoms with a function to inhibit oxidation, come either from dietary sources or are produced by the body.

In contrast to general belief, free radical is also needed in a moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

In a healthy person, oxidative stress is harmful because it not only induces cell's lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.

Ozone, certain pesticides, cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.

Liver stress markers such as serum MDA refer to oxidative stress in the liver tissues caused by the overexpression of free radicals or reduced levels of antioxidant enzymes in the liver.


Dr. Halina Cichoż-Lach, the lead scientist said, "Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases.".

And, "Hepatocytic proteins, lipids, and DNA are among the cellular structures that are primarily affected by ROS and reactive nitrogen species. The process results in structural and functional abnormalities in the liver".

In other words, liver oxidative stress over the long-term induced damage of proteins, and lipid and alternation of cell DNA can lead to liver diseases, including cancer.

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belonging to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a natural compound for the prevention of liver stress, researchers examined the effect of cabbage, green beans, or seeds from sunflowers grown either on municipal sewage sludge-amended soil or soil alone fed to male and female Coturnix quail, as 50% of a complete diet, for 5 weeks.


Green beans fed male and female Coturnix quail exhibited liver GST activities significantly lower compared to those fed with sludge-grown cabbage.


Compared to the levels of liver glutathione S-transferase (GST) soil-grown cabbage demonstrated a two-fold activity increase in birds fed the other plants.

More precisely, the levels of glucosinolates present in the cabbage, are 3040 and 9253 ppm (dry basis) in the sludge-grown and soil-grown cabbage, respectively.

In other words, green beans showed a significant reduction of liver stress markers lesser than those of cabbage, regardless of soil cultivation.

Taken altogether, green beans may be considered a liver-protective veggie, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Changes in liver glutathione S-transferase activities in Coturnix quail-fed municipal sludge-grown cabbage with reduced levels of glucosinolates by Stoewsand GS, Anderson JL, Lisk DJ. (PubMed)
(2) Oxidative stress as a crucial factor in liver diseases by Halina Cichoż-Lach and Agata Michalak (PMC)