Herbal #Alfalfa Inhibits the Risk of Type 2 Diabetes, Researchers Reveal

By Kyle J. Norton

Scientists may have found a whole herb that processes anti-diabetes property, some scientists suggested.

Diabetes is a chronic condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as a result of either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

In some cases, diabetes may also be caused by allergic reactions of cells in the immune system.
The actual causes of diabetes inflammatory conditions are debatable.

Some researchers also do not know why some people without genetic mutations are susceptible to type 2 diabetes while others do not.

However, certain risk factors such as overweight and obesity (overexpression of fatty tissue that causes insulin resistance), physical inactivity, family history, race,,,,, and age. ...

Women who developed gestational diabetes, polycystic ovary syndrome,.... and high blood pressure is also some major risk factors associated to increase risk of type 2 diabetes.

The first line of medicine used for the treatment of type 2 diabetes is metformin which processes a significant effect in improving the body tissue sensitivity to insulin. In other words, metformin improves the body's use of insulin more effectively. and lowers glucose production in the liver.

In the stage of prediabetes, patients may not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may increase the risk of cataracts and glaucoma, foot damage.

In the advanced stage, untreated diabetes can also cause nerve damage or poor blood flow to the feet which in turn, increases the risk of various foot complications.

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding.

The leaves, sprouts, and seeds to make medicine that has been used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorders, kidney, and urinary tract infections, etc. North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.

Ingredients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11. Vitamin E
12. Vitamin K

Its chemical constituents include flavones, isoflavones, sterols, Bichanin, Coumestrol, Diadzein, Formonetin, Genistein,.... and coumarin derivatives.

In the study to examine the Lucerne (alfalfa) effect by orally administrating of the herbal extract through diet (62.5 g/kg) and drinking water (2.5 g/l) in reducing the hyperglycemia of streptozotocin-diabetic mice, researchers found
* Application of an aqueous extract of lucerne exerts a significant stimulation of insulin secretion from the pancreatic B-cell line.

* Application of aqueous extract of lucern also promotes insulin-like activity in inhibited overexpression glucose.

* The sequential extraction with solvents revealed .higher insulin-releasing activity in both methanol and water fractions compared to one extract constituent.

Further analysis also suggested that the activity of the extract was found to be heat stable and enhanced by exposure to acid and alkali (0.1 M-HCl and NaOH).

Dr. Gray AM, the lead author of the final report wrote, "The results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Medicago sativa".

Additionally, in the study to reaffirm the effect of herbal alfalfa against the onset of diabetes researchers launched a study to compare alfalfa with other herbal medicine including dried leaves of agrimony (Agrimonia eupatoria), blackberry (Rubus fruticose), celandine (Chelidonium majus), eucalyptus (Eucalyptus globulus), lady's mantle (Alchemilla vulgaris), and lily of the valley (Convallaria majalis); seeds of coriander (Coriandrum sativum); dried berries of juniper (Juniperus communis); bulbs of garlic (Allium sativum) and roots of licorice (Glycyrhizza glabra).

In mice administrated by streptozotocin (200 mg/kg i.p.) to induce the development of hyperphagia, polydipsia, body weight loss, hyperglycemia, and hypoinsulinemia, researchers found that

* Herbal alfalfa exerts a strong effect in reducing the level of hyperglycemia during the development of streptozotocin diabetes compared to others herbs.

* Herbal alfalfa reduced polydipsia and a reduced rate of body weight loss.

* Alfalfa initially countered the hyperinsulinaemic effect of streptozotocin, without affecting the fall in plasma insulin.

Dr. said, after taking into account other co and confounders, " The results suggest that certain traditional plant treatments for diabetes, namely alfalfa,.......can retard the development of streptozotocin diabetes in mice".

Taking all together, herbal alfalfa may be considered a functional herb for the prevention and treatment of type 2 diabetes.

However, additional data collection on large example size and multi-center clinical studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of alfalfa anti-type 2 diabetes possibilities.

And long-term multiple dietary supplement consumption of a broad array of vitamin/mineral, herbal, and condition-specific dietary supplements on a daily basis should consult with their doctors or related field specialist before applying.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne) by Gray AM, Flatt PR. (PubMed)
(2) Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. (PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)

#Healthyfood #Cabbages Reduce the Risk of Mitochondrial Dysfunction Induced by Oxidative Stress

By Kyle J. Norton

Mitochondria are the cell that converts food molecules into energy for the body tissues' needs. Mitochondria produce 90 percent of the energy for body functioning.

Mitochondrial dysfunction is a condition affecting the organelles that generate energy for the cell.

The genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people. Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer.

Acquired mitochondrial dysfunction caused by the long-term use of certain medications such as Metformin, medical conditions such as mitochondrial encephalomyopathy or infection, and environmental influences, such as xenochemicals, can lead to less and less energy generated within the cells.

The most common symptoms of mitochondrial dysfunction include poor growth
muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, and mental retardation depending on the location of the infected cells.

Diseases associated with mitochondrial dysfunction include Autism, autism-like features Heart, liver, or kidney diseases, gastrointestinal disorders, diabetes, neurological problems, thyroid, and respiratory (breathing) problems, and dementia.

Conventionally, treatments for mitochondrial dysfunction are totally depending on the causes of the disease.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem which is crowded with a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find natural food for the protection of mitochondrial function, researchers examined the effects of cabbage extract on oxidative stress in H9c2 cardiomyoblasts.
According to the tested differentiation,
* Cabbage extract protected against H2O2-induced cell death and did not elicit any cytotoxic effects.

* Cabbage extract suppressed ROS production and increased expression of antioxidant proteins (SOD-1, catalase, and GPx).

* Cabbage extract also inhibited apoptotic responses and activation of MAPK proteins (ERK1/2, JNK, and p-38) in oxidative stress-exposed H9c2 cells.


Precisely, cabbage extract preserved mitochondrial functions upon oxidative stress.

Taken altogether, cabbage may be considered a remedy for the protection of mitochondrial dysfunction, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cabbage (Brassica oleracea var. capitata) Protects against H2O2-Induced Oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2Cardiomyoblasts by Yang DK. (PubMed)

#Healthyfood #Honey Exhibits Anti Hypertensive Property with No Side Effects

By Kyle J. Norton

In seeking a natural therapy with no side effects, scientists may have a herbal remedy for normalizing blood pressure, according to studies.

Hypertension is a chronic condition caused by abnormally high blood pressure.

High blood pressure is a condition of a cluster of metabolic syndrome associated with the increased risk of heart disease and stroke.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

In high blood pressure individuals, due to the elevated blood pressure in your arteries, the heart has to work harder than normal to pump blood through the blood vessels.

In low blood pressure individuals, the reduced blood pressure in the arteries drops can cause the heart to pump blood at a slower rate than normal.


According to the standard guidelines, the levels of blood pressure is normal if it is more than 120 over 80 and less than 140 over 90 (120/80-140/90).


People with blood pressure lower than 120/80 are considered normal without being accompanied by symptoms of light-head or dizziness.

According to the statistics provided by the CDC, in the U.S. 29% or 100 million of adults have hypertension during 2015–2016 and hypertension prevalence increased with age and was 33.2% among those aged 40–59 and 63.1% among those aged 60 and over.


Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

Researchers in the course of finding a natural ingredient for the treatment of high blood pressure investigated the safety and effect of intrapulmonary administration (by inhalation) of 60 % honey solution, 10% dextrose, or distilled water in normal or diabetic subjects.

Twenty-four healthy subjects, 16 patients with type 1 diabetes mellitus, and six patients with hypertension were selected to participate in the study.

Twelve healthy subjects were subjected to distilling water inhalation for 10 min, and after one week they received inhalation of honey solution (60% wt/v) for 10 min. Another 12 healthy subjects received inhalation of 10% dextrose for 10 min.

Honey treatment showed a mild reduction of blood pressure compared to no change in another group.

From a time perspective, systolic and diastolic blood pressure was reduced by honey inhalation in hypertensive patients at 60 and 120 min.


After taking into account co and confounders, researchers said, "Honey inhalation was safe and effective in reducing...elevated blood pressure in hypertensive patients".

Moreover, in order to obtain more information on honey antihypertensive activity, researchers investigated the aqueous extract obtained from the mixture of the fresh leaf of Persea Americana, stems, and a fresh leaf of Cymbopogon citratus, fruits of Citrus medica, and honey on ethanol and sucrose-induced hypertension in rats.

Rats included in the study were divided into eight groups of 6 rats each and daily treated for 5 weeks. The control group received distilled water (1 mL/kg) while rats of groups 2, 3, and 4 received ethanol 40 degrees (3 g/kg/day), 10% sucrose as drinking water, and the two substances respectively.

The remaining groups received additional sucrose and ethanol, the aqueous extract (50, 100, and 150 mg/kg) and nifedipine (10 mg/kg) respectively.

The group treated with ethanol and sucrose showed a significant (p < 0.001) increased blood pressure and heart rate compared to distilled water-treated rats.

Chronic treatment of ethanol and sucrose also exerted a significantly decreased the activities of antioxidant enzymes produced by the host, observed by the levels of superoxide dismutase (SOD) and catalase (CAT) and elevated levels of oxidative stress observed by the stress marker malondialdehyde (MDA) levels.

However, administration of the aqueous extract or nifedipine prevented all changes caused by chronic ethanol and sucrose, including hemodynamic, biochemical, oxidative, and histological impairments.

The finding clearly suggested that aqueous extract including honey possesses antihypertensive activity through the improvement of biochemical and oxidative status, through its antioxidant property.

Taken altogether, honey used alone or combined with other herbs may be considered anti-hypertension functional remedies with no side effects, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intrapulmonary administration of the natural honey solution, hyperosmolar dextrose, or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: their effects on blood glucose level, plasma insulin, and C-peptide, blood pressure and peaked expiratory flow rate by Al-Waili N1. (PubMed)
(2) Antihypertensive potential of the aqueous extract which combines the leaf of Persea americana Mill. (Lauraceae), stems and a leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P. (PubMed)

Phytochemical Beta-Sitosterol Processes Anti-Hyperglycemia and Anti-Diabetes Activity

By Kyle J. Norton

Diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Latent autoimmune diabetes in adults (LADA), similar to type 1 diabetes, is a slow-progressing form of autoimmune diabetes. The disease is caused by the pancreas' inability to produce enough insulin, because of slowly die-off of insulin-producing cells in the pancreas.

LADA is also known as type 1.5 diabetes because the disease has characteristics of both type 1 (autoimmune in nature) and type 2 diabetes.

Unlike type 2 diabetes, patients with LADA do not respond well to seems to lifestyle and medication as in type-2 diabetes in the long term. Medicine used for the treatment of type 2 diabetes does not halt or slow the progression of loss of pancreas beta cells.

 Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Although hyperglycemia is a hallmark in patients with diabetes, the condition can also occur in people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly and can be controlled by the following diabetes guidance. 

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention of diseases involved in high blood sugar, researchers evaluated the antioxidant potential of β-sitosterol (BS), a phytosterol from Solanum surat-tense, using an experimental model for diabetes-induced oxidative damage.

According to the results from the study of 21 days of treatment with BS (10, 15, and 20 mg/kg, p.o.) on blood, serum, in control and streptozotocin-induced diabetic rats that were divided into 9 experimental groups, including a control group, a diabetic group, and BS- and glibenclamide-treated diabetic groups.

All application doses dependently showed a decrease of glycated hemoglobin, serum glucose, and nitric oxide, with concomitant increases in serum insulin levels.

In other words, β-sitosterol (BS), exerted anti-hyperglycemic activity to protect the diabetics against complications caused by improper management of high blood glucose in a dose depending manner.

Moreover, treatment with BS doses also increased pancreatic antioxidant levels against the pancreatic oxidative stress-induced the death of beta cells with a concomitant decrease in thiobarbituric acid-reactive substances.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of diabetes, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia by Gupta R1, Sharma AK, Dobhal MP, Sharma MC, Gupta RS. (PubMed)

Phytochemical Quercetin Found in Onion in the Inhibition of Angiogenesis, Researchers Say

By Kyle J. Norton

Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.

In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.

Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumor proliferation and metastasis.

More precisely, the angiogenesis process function as a double sword, on one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.

Dr. Papetti M continued, "tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"

Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".

Based on the findings some researchers suggested, by inhibiting the process of blood vessels formation of the tumor, cancer may be curable.

Dr. Dai X, the lead researcher in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".


The onion is a plant in the genus Allium, belongings to the family Alliaceae, which a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

On finding a potent ingredient that processes anti-cancer activity researchers studied the antiangiogenic activity of quercetin isolated from onion, using ex vivo, in vivo, and in vitro models.

According to the tested differentiation, quercetin at non-toxic concentrations significantly inhibited the microvessel sprouting associated with cancer cell proliferation.

Furthermore, the activity of cancer cell migration, invasion, and tube formation of endothelial cells is involved in the process of angiogenesis.was also significantly decreased by the administration of quercetin.

Quercetin treatment inhibited ex vivo angiogenesis observed by chicken egg chorioallantoic membrane assay (CAM) and matrigel plug assay.

Moreover, quercetin suppressed vascular endothelial growth factor (VEGF) which has been found to induce the formation of a blood vessel for the progression of the tumor.

Additionally, downstream pathways associated with the promotion of survival and growth in response to extracellular signals that induce angiogenesis were also inhibited by quercetin in HUVECs.

Quercetin at the concentration of 20 mg/kg/d significantly reduced the volume and the weight of solid tumors in a prostate xenograft mouse model by targeting angiogenesis.

Quercetin was also found to inhibit cancer cell viability and induced apoptosis in prostate cancer cells.

In other words, quercetin inhibits tumor growth and angiogenesis by targeting the proteins and signaling pathways that initiate the growth of new blood vessels.


Taken altogether, onion processed with a higher amount of quercetin may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways by Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, and Xianglin Shi. (Plos One)
(2) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Dai X1,2, Jiang P2, Ji Y3, Zhu X2, Sun X. (PubMed)

Phytochemical Beta-Sitosterol Inhibits the Multi-Factorial Drug-Resistant cancer cells

By Kyle J. Norton

Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.

At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of the cancer.

Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.

Some cancers can be slow-growth, including prostate and colon cancer. Primary cancer at stages 0 and 1 may not induce any symptoms. However, at the later stage, a larger size tumor can induce specific symptoms depending on the affected organ accompanied by some general symptoms found in all types of cancer.

According to the statistic provided by the American Cancer Society, in the US in 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths as are the result of cancer.

The multifactorial nature of tumor drug resistance refers to the limited ability of cancer drugs to penetrate tumor tissue and reach tumor cells in a potentially lethal concentration to induce toxicity.

In other words, cancer cell resistance to chemo drugs contributes to significantly low efficacy of cancer therapy with often reoccurrence.

Dr. Solyanik GI, in the study of chemo drug resistance, wrote, "Tumor drug resistance (TDR) remains a major obstacle for successful treatment of cancer. Till the ninetieth years of the past century, the resistance of tumors to anticancer drugs was most often ascribed to gene mutations, gene amplification, or epigenetic changes that influence the uptake, metabolism or export of drugs from single cells".

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the treatment of cancer, researchers examined the cytotoxic effects of the crude extract (FTB), fractions (FTBa-d), and compounds isolated from the bark of Fagara tessmannii, namely lupeol (1), fagaramide (2), zanthoxyline (3), hesperidin (4), nitidine chloride (5), fagaridine chloride (6), and β-sitosterol-3-O-β-D-glucopyranoside (7) on multi-factorial drug-resistant cancer cells.

The compound 6, β-sitosterol-3-O-β-D-glucopyranoside showed a strong effect in inducing cytotoxicity on 9 tested cancer cell lines in a doses-depending manner, depending on the types of cancer.

Furthermore, compound 6 demonstrated anticancer activity with 1.69 µM against CCRF-CEM cells and 22.06 µM against HepG2 hepatocarcinoma cells, compared to 0.02 µM against CCRF-CEM cells to 122.96 µM against CEM/ADR5000 cells for doxorubicin.

Moreover, compound 6 also induced apoptosis mediated by caspases activation associated with cell death programming, MMP alteration in enhancing the ROS production to induce cancer cell cytotoxicity.

Based on the results, researchers said, "... (compound) 6 revealed considerable cytotoxicity and may be suitable candidates deserving to be further explored to develop new anticancer drugs to combat sensitive and resistant phenotypes".

Taken altogether, beta-Sitosterol may be considered a functional food for the prevention and treatment of multi-factorial drug-resistant cancers, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxicity of the crude extract and constituents of the bark of Fagara tessmannii towards multi-factorial drug resistant cancer cells by Mbaveng AT1, Damen F2, Çelik İ3, Tane P2, Kuete V4, Efferth T. (PubMed)
(2) Multifactorial nature of tumor drug resistance by Solyanik GI. (PubMed)

Elevated Levels of Alpha Tocopherols May Contribute to the Risk of Uterine Fibroids

By Kyle J. Norton


A fibroid is a benign tumor that grows in, on, or outside of the wall of the uterus. If it grows big enough, it may interfere with the implantation of the embryo in the uterus, leading to premature delivery, miscarriage, and increasing the risk of infertility, if they grow near the opening of both Fallopian tubes and distort the shape of uterine captivity.

According to the statistic from National Uterine Fibroid Foundations, approximately 80% of all women have uterine fibroids with the majority usually having no symptoms. Every 10 minutes, 12 hysterectomies are performed in the United States alone.

Uterine fibroids are benign tumors that originate in the uterus (womb).

Abnormal uterine bleeding is the most common symptom of a fibroid. If the mass of the fibroids is near the uterine lining or interferes with the blood flow to the lining, they can cause heavy periods, painful periods, prolonged periods, or spotting between menses.

According to the statistics from the information on government of women's health, approximately 20 percent to 80 percent of women develop fibroids by the time they reach age 50.

Fibroids are the most common reproductive diseases in women in their 40s and early 50s. Some women with fibroids are asymptomatic.

The common symptoms of uterine fibroids are
* Abnormal vaginal bleeding
Vaginal bleeding between periods within inappropriate amounts of blood flow should be checked with the doctor as soon as possible. It may be caused by the expansion of overgrowth of pre-cancer uterine lining cells infection or breaking off the endometrial capillaries or blood vessels.

*Increased amount of vaginal discharge
An increase in the amount of vaginal discharge accompanied by abnormal odor or pain, itching, or burning sensation may be caused by infection or inflammation.

* Painful urination
Painful urination, most of the time is caused by an infection of the urinary tract that affects the bladder emptying, but sometimes it can be caused by infectious diseases and may be an indication of pre-endometrial cancer.

* Pain during sex
Most of the time is caused by vestibulitis and vaginismus sex, but in some cases, it can be caused by cancer or other reproductive diseases.

* Pain in the abdomen
There are many reproductive diseases that can cause pain in the pelvis, such as appendicitis, salpingitis, uterine descensus, etc. but it can be caused by the early stage of endometrial cancer.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of diseases associated with reproductive organs in women, researchers examined the effects of tocopherols on uterine fibroids (UFs).

A total of 162 patients who participated in the study were divided into 2 groups: with UFs and controls.

According to the UFs confirmed on ultrasound and controls, the levels of AT serum concentrations were 11.66 ± 4.97 μg/ml and 7.83 ± 3.13 μg/ml (medians 10.56 μg/ml and 7.42 μg/ml).

In other words, high levels of alpha-tocopherol (AT) are associated with an increased risk of UFs.

Higher BMI, positive family history, and low parity were found to be major risk factors for UFs.

Based on the findings, researchers said, "Elevated serum AT concentration might be an important risk factor for UFs in Caucasian women. Further research in this area is necessary".

Taken altogether, alpha tocopherols may induce uterine fibroids, pending the confirmation of the larger sample size and multicenter human study.

Intake of alpha tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alpha-Tocopherol Serum Levels Are Increased in Caucasian Women with Uterine Fibroids: A Pilot Study by Ciebiera M1, Szymańska-Majchrzak J2, Sentkowska A3, Kilian K3, Rogulski Z4, Nowicka G5, Jakiel G1, Tomaszewski P6,7, Włodarczyk M. (PubMed)