Broccoli' Sulforaphane (SFN), a Natural Chemo-Preventive Phytochemical

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Chemo-drugs are a class of conventional medicine used for the treatment of cancers. including 5-fluorouracil, 6-mercaptopurine, cytarabine, gemcitabine, and methotrexate.

Compared to other treatments, chemotherapy targets cancer's specific genes, proteins, or the tissue environment that contributes to cancer growth and survival.

Chemo drugs have been found to improve the survival rate of cancer patients. However, they also induce significant side effects.

The most common side effects of chemo-drugs are fatigue, hair loss, easy bruising, and bleeding. infection, anemia (low red blood cell counts) nausea and vomiting, appetite changes and constipation.

The side effects of chemo drugs are the results of damage to the healthy blood-forming cells in the bone marrow, hair follicles, and cells in the mouth, digestive tract, and reproductive system.

According to the American Cancer Society, some chemo drugs have also been found to damage cells in the heart, kidneys, bladder, lungs, and nervous system.

Chemoprevention is the use of a medication, vitamin or supplement to prevent the initiation of cancer.

On finding a potential plant for the treatment of cancers, researchers compared the effects of
Brassica family of cruciferous vegetables such as broccoli is a rich source of isothiocyanates, sulforaphane (SFN) as chemopreventive phytochemical.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

According to the differentiation, sulforaphane (SFN) exerted its potent chemopreventive agent based on its ability to target multiple mechanisms within the cell to control carcinogenesis.

More precisely, anti-inflammatory, pro-apoptotic and modulation of histones are some of the more important and known mechanisms by which SFN demonstrates chemoprevention.

Furthermore, The effect of SFN on cancer stem cells is another area of interest that has been explored in recent years and may contribute to its chemopreventive properties.

Based on the results, researchers said, "In this paper, we briefly review structure, pharmacology and preclinical studies highlighting chemopreventive effects of SFN".

Taken altogether, broccoli consists of SFN may be considered a chemopreventive functional food, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review by Bayat Mokhtari R1,2,3,4, Baluch N5, Homayouni TS6, Morgatskaya E6, Kumar S6, Kazemi P6, Yeger H. (PubMed)https://www.ncbi.nlm.nih.gov/pubmed/28735362

Healthy Cynometra Cauliflora, the Anti-Obesity Functional Foods

By Kyle J. Norton

Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obese.

In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.

Similar to other chronic medical conditions including diabetes, cardiovascular disease or high blood pressure, obesity has recently become a serious health problem in the US as nearly 35% of Americans are obese accompanied by a similar percentage of overweight adults.

Obesity and overweight on the U.S. economy have eclipsed $1.7 trillion, equivalent to 9.3 percent of the nation's gross domestic product, according to a new overweight report on chronic diseases.

Dr. Maximilian Tremmel, the lead scientist in a systematic literature review of the economic burden of obesity, wrote, " almost half of the world’s adult population will be overweight or obese by 2030 if the prevalence continues on the current trend [6] and consequently also the costs attributable to obesity will increase"

And, "A useful example for rapidly rising costs attributable to obesity from these selected studies are the two mentioned studies from Germany [44,46]. The results of the two papers together show that total societal costs in Germany due to obesity have increased from €9.8 million to €12.2 million between 2002 and 2008. Therefore, public health interventions should focus on the prevention of obesity as soon as possible, ideally at a young age".

Description

Cynometra cauliflora is a species of the genus Cynometra, native to Malaysia, and found mainly in northern Peninsular Malaysia.

On finding a potential phytochemical for the prevention and treatment of chronic diseases, researchers examined the anti-obesity and lipid-lowering effects of ethanolic extract of C. cauliflora leaves and its major compound (vitexin) in C57BL/6 obese mice induced by high-fat diet (HFD).

The study included male C57BL/6 mice induced obese by feeding with HFD (60% fat) for 16 weeks followed by the treatment that starts during the last 8 weeks of HFD feeding with C. cauliflora leaf extract at 200 and 400 mg/kg/day, orlistat (10 mg/kg) and vitexin (10 mg/kg).

According to the chemical analysis,
* The oral administration of C. cauliflora (400 and 200 mg/kg) and vitexin significantly reduced body weight, adipose tissue and liver weight and lipid accumulation in the liver compared to control HFD group.

* Both doses of C. cauliflora also significantly (P ≤ 0.05) decreased serum triglyceride, LDL, lipase, IL-6, peptide YY, resistin levels, hyperglycemia, hyperinsulinemia, and hyperleptinemia compared to the control HFD group.

* C. cauliflora significantly up-regulated the expression of adiponectin, Glut4, Mtor, IRS-1 and InsR genes associated with the sustaining weight loss and significantly decreased the expression of Lepr in white adipose tissue involved in stimulating weight gain.

Based on the findings, researchers said, "This study shows interesting outcomes of C. cauliflora against HFD-induced obesity and associated metabolic abnormalities".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of bacterial infectious diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice by Seyedan A1, Mohamed Z2, Alshagga MA3, Koosha S4, Alshawsh MA. (PubMed)
(2) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)

Herbal Ashwagandha, an Adjunct Therapy for Cystic Fibrosis

By Kyle J. Norton

Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in children and young adults, leading to difficulty breathing and coughing up mucus due to frequent lung infections.

However, the condition has also been found in the pancreas, liver, kidneys, and intestine.

According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.

Believe it or not, most cases of CF are diagnosed by age 2.

The most common symptoms are depending on the location of cystic fibrosis including
sinus infections, poor growth, fatty stool, clubbing of the fingers and toes.

In male adults, the condition also induces infertility as a result of the blockage or absence of the sperm canal.

Conventionally, as of today, there is no cure for CF. Most cases of CF caused by lung infection are treated intravenously, inhaled, or by mouth.

In severe cases, a lung transplant may be the only option.

Although most cases of CF are associated with a genetic preposition, environment, lifestyle, and age are also 2 main factors that increase the risk of CF.

According to statistics provided by the Canadian Cystic Fibrosis Foundation, approximately 1 in every 3,600 children born in Canada has CF.

In age perspective,
* 60% of patients are diagnosed in the first year of life, and 90% by 10 years of age.

* More than 47% of all Canadians with CF are over the age of 18 years.

* As of 2002, the median age of survival of Canadians with CF is 37 years of age.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the treatment of diseases associated with genetic disorders, researchers examined the effects of Withaferin A (WFA), a steroidal lactone from the plant Withania Somnifera L. Dunal on cystic fibrosis.

According to the tested analysis, WFA blocks platelet-activating factor (PAF)-induced activation of NFκB in the induction of inflammation through the innate immune cells and inflammatory T cells.

More precisely, WFA inhibited the NFκB activation that leads to a reduction of the increased expression of IL-8 and NFκB subunit p65 translocation involved in inflammation.

In other words, WFA demonstrated anti-inflammatory activity in the cystic fibrosis model.

Based on the evidence, researchers said, "the airways of CF patients can be specifically targeted for delivery of therapeutics, we propose that WFA should be further studied as an anti-inflammatory agent in models of CF-related inflammation mediated by NFκB".

Taken altogether, Ashwagandha processed a high amount of bioactive compound WFA may be considered supplements for the treatment of cystic fibrosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation by Rangan Maitra, Melissa A Porter, Shan Huang & Brian P Gilmour (BMC)

Dandelion(Taraxacum Officinale) Exerts an Inhibitory Activity Against the Risk of Metabolic Syndrome

By Kyle J. Norton  

Metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Cardiovascular diseases refer to heart diseases, affecting millions of people in the world. According to statistic, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors of the diseases.

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Symptoms of signs of metabolic syndrome depending on types of affected conditions and complications.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of cardiovascular diseases, scientists examined the effects of Boldocynara® (Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus) as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome.

According to the tested differentiation, the combination exerted moderate to weak effects on the tested liver enzymes against metabolic syndrome.

In the individual herb analysis, 

* Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml) associated with a metabolic modifier that could reduce the risk of CVD in patients with the metabolic syndrome.

* Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) involved in lipid metabolism disorder.

* Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml) in reducing the risk of CVD.

In other words, all individual herbal medicine work synergistically to induce inhibitory activity against all parameters in inducing the risk of metabolic syndrome.

Based on the results, researchers suggest, " our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders".

Taken altogether, Dandelion used in a combination with other herbs may be considered a formula for the prevention of metabolic syndrome, pending to the conirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome by Villiger A1, Sala F1, Suter A2, Butterweck V. (PubMed)

Omega-3 Fatty Acids Promotes Neuro-Functioning After Ischemic Stroke

By Kyle J. Norton


Cardiovascular diseases refer to heart diseases and stroke, affecting millions of people in the world.

According to statistic, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors of the diseases.

In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagic, due to bleeding.

A stroke is a medical emergency. Early intervention is most cases can minimize brain damage and potential complications.

Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.

Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.

There is a general belief that stroke is an accumulation over a long period of the unhealthy diet with red meat and processed meats in the induction of artery-clogging.

Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow and decreased the chance of blood clots.

Sadly, stroke is one of the most common causes of death worldwide.

In the US, according to statistics, approximately 800,000 people suffer a stroke in which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

According to the statistics, in the US, stroke is the leading cause of serious, long-term disability.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the effects of mega-3 polyunsaturated fatty acids (n-3 PUFAs) in alleviating ischemic brain injury in young adult rodents.

The study included aged (18-month-old) mice which were administered n-3 PUFA-enriched fish oil in daily chow for 3 months before and up to 8 weeks after 45 minutes of transient middle cerebral artery occlusion (tMCAO).

According to the results of differentiation,
* Mice receiving dietary supplementation of n-3 PUFAs for 3 months showed significant increases in brain ratio of n-3/n-6 PUFA contents.

* Furthermore, the administration of dietary supplementation of n-3 PUFAs for 3 months also markedly reduced long-term sensorimotor deficits and chronic ischemic brain tissue loss after tMCAO.

* Moreover, n-3 PUFAs robustly promoted post-ischemic angiogenesis and neurogenesis to enhance the brian neuron activity and enhanced white matter integrity after tMCAO.

* Most importantly, the enhancement of neurogenesis and white matter integrity were both correlated positively with the improvement of sensorimotor activities after tMCAO.

Collectively, researchers said, "prophylactic dietary supplementation of n-3 PUFAs effectively improves long-term stroke outcomes in aged mice, perhaps by promoting post-stroke brain repair processes such as angiogenesis, neurogenesis, and white matter restoration".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the improvement of long-term stroke outcomes, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids by Cai M1, Zhang W1, Weng Z2, Stetler RA1,2,3, Jiang X2, Shi Y2,3, Gao Y1,2, Chen J. (PubMed)
(2) Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts by Saber H1, Yakoob MY1, Shi P1, Longstreth WT Jr1, Lemaitre RN1, Siscovick D1, Rexrode KM1, Willett WC1, Mozaffarian D. (PubMed)

Herbal Angelica May Be Prescribed for The Treatment of Ovulatory Infertility

By Kyle J. Norton

Infertility is a reproductive disease characterized by the failure to produce a pregnancy after 12 regular unprotected sexual intercourse, including pregnancy that can not be carried to term.

Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).

Believe it or not, only a very small number of such groups are seeking help from the professionals.

In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.

In women, certain risk factors including age, excessive, or very low, body fat, medical conditions such as diabetes, hormone imbalance, previous miscarriage and unhealthy lifestyle, such as smoking, excessive alcohol consumption may affect the ovulation of a woman.

The leading cause of female infertility, that affects nearly 25 percent of infertile couples, is a problem with ovulation, also known as an ovulatory disorder.

The ovaries are oval-shaped ovum-producing reproductive organ formed part of women reproductive system that connects to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary take a turn to release an egg every month.

Painful ovulation is a condition caused by a small leakage of blood from the ovary occurring at the time of ovulation, leading to irritation of the abdominal wall that results in cramps and pain in either left or right side of the abdomen depending on which side of ovaries is responsible for the development of follicles.

Ovulatory infertility is a condition of infertility associated with ovulatory problems including irregular or infrequent ovulation or no ovulation at all.

According to statistics, 25% of female infertility is involved in ovulatory infertility.

On finding a natural ingredient for the prevention and treatment of infertility in females scientists analyzed Professor Ma Kun's collected medication in treating anovulatory infertility, her prescriptions for treating anovulatory infertility in 2012-2015.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the differentiation of a total of 684 prescriptions and 300 kinds of herbs were screened out, with a total frequency of 11 156 times,
* The top three frequently used herbs by effect were respectively tonic herb, blood circulation promoting herb, and Qi-circulation promoting herb.

* The top three tastes were sweetness, bitterness and pungent flavor. The results showed 28 herbs with a high frequency of ≥100.

Compared to the top 10 frequent use herbal medicine for the treatment of ovulatory infertility, Angelica Sinensis Radix is the most frequently used herb compared to Cyperi Rhizoma, Chuanxiong Rhizome, Paeoniae Radix Rubra, Cyathulae Radix, Taxilli Herba, Cuscutae Semen, Codonopsis Radix, Ligustri Lucidi Fructus, Paeoniae Alba, and Paeoniae Radix Alba. 

In other words, herbal angelica process the properties that were used by professor Ma for the treatment of anovulatory infertility, because of the herbal effects in nourishing the kidney and activating blood throughout the treatment course and attached the importance to the relationship between Qi and blood and the regulation of liver, spleen, and kidney.

Taken altogether, herbal angelica used alone or in a combination with other herbal remedies may be used for the treatment of ovulatory infertility, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Features of Professor Ma Kun's medication in treating ovulatory infertility].[Article in Chinese] by Tong YJ1, Zhang HX1, Chen YX1, Dong ML1, Ma K. (PubMed)

Cruciferous Vegetables Gobbles Up Melanoma Cells in Vitro

By Kyle J. Norton

Skin diseases are conditions of skin damage and classified according to each pathogenic cause.

Most cases of skin disease are involved in allergens, irritants. However certain medical conditions such as irritable bowel disease, autoimmune diseases, and genetic preposition can also cause r skin diseases.

Recent studies suggested that a poor diet is also associated with the onset of skin diseases such as the dermatological disease may be linked to systemic disease, and dietary changes may affect health outcomes, as in psoriasis.

Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.

Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.

The most common sites of melanoma metastasis are the lung and breast.

According to the statistic, melanoma skin cancer is increasing and anticipated to continue to rise. In the United States, approximately 70,230 new cases of melanoma were diagnosed, causing the death of 8,790.

The causes of melanoma skin cancer are associated with the alternation of the pigment cells in the skin. Why some people are susceptible to the onset of the disease while others do not even share similar health conditions, family history, and ethnicity.

However, according to the epidemiological studies, genetic mutation inherited from the parent, exposure to the environmental toxins and sun UV rays are the most common associated with the increased risk of melanoma skin cancer. 

On finding a potential plant that processes anti-cancer activity researchers investigated the effects of indole-3-carbinol (I3C), a natural anti-cancer phytochemical derived from cruciferous vegetables such as cabbage and broccoli, as a new chemical scaffold of small molecule enzymatic inhibitors of NEDD4-1 on human cancer cell lines.

Where NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN, a tumor suppressor that plays a critical regulator for multiple cellular processes. The gene is mutated or deleted frequently in various human cancers.

According to the tested assays,

*  I3C's stable synthetic derivative 1-benzyl-I3C showed to directly inhibit NEDD4-1 ubiquitination activity.

* Furthermore, compared to I3C, which has an IC50 of 284μM, 1-benzyl-I3C was a significantly more potent NEDD4-1 enzymatic inhibitor with an IC50 of 12.3μM.

* The compounds 2242 and 2243, (the two indolecarbinol analogs with added methyl groups) result in a more nucleophilic benzene ring π system, further enhanced potency with IC50s of 2.71μM and 7.59μM, respectively.

* Most importantly, the indolecarbinol compounds inhibited human melanoma cell proliferation in a manner that generally correlated with their effectiveness as NEDD4-1 enzymatic inhibitors.


Based on the findings, researchers said, " I3C analogs represent a novel set of anti-cancer compounds for the treatment of human melanomas and other cancers that express indolecarbinol-sensitive target enzymes".

Taken altogether, cruciferous vegetables consisting of indole-3-carbinol (I3C) and five novel synthetic analogs may be considered a functional food for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells by Quirit JG. (PubMed)