Herbal Dandelion(Taraxacum officinale) Treatment of Intestinal Metaplasia (IM) and Atypical Hyperplasia (AH)

By Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.

The stomach plays a critical role in aiding the digestive system by secreting acid and enzymes that digest food induced by the stomach muscles that contract periodically, to churn the food and enhance digestion.

Atypical hyperplasia is a precancerous condition characterized by the accumulation of abnormal cells.

Intestinal metaplasia is a pre gastric cancer condition caused by the change of cells in the stomach.

The exact causes of the condition are unknown. However, some researchers suggested that smoking, and infection caused by H. pylori infection, genetic preposition and environment factors are some risk factors associated with the onset of intestinal metaplasia.

Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.

Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.

Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of gastric diseases, scientists examined the efficacy of Xiao Wei Yan Powder (XWYP) decoction on intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH).

Where  XWYP is a traditional Chinese Medicine formula containing Smilax glabrate, Hedyotis diffusae, Taraxacum mongolicum, Caesalpinia sappan, Paeonia alba, Cyperus rotundus, Bletilla striata, Glycyrrhiza uralensis, etc.

According to the results of 138 cases of intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH) of the gastric mucosa of chronic gastritis that was treated by Xiao Wei Yan Powder (XWYP) orally 5-7g, for a period from 2-4 months, compared to control, the decoction showed a significant effect rate of IM was 91.3% and that of the AH was 92.16% compared to the control group of 21.3% and 14.46% respectively.

More precisely, XWYP not only had marked therapeutic effects for IM and AH but also showed no toxic effects in the animal experiments revealed no toxic effect,

These results strongly suggested that a safety guarantee was provided for its clinical application.

Taken altogether, Dandelion in a combination with other Chinese medicines may be considered a remedy for the treatment of intestinal metaplasia and atypical hyperplasia (AH), pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Treatment of intestinal metaplasia and atypical hyperplasia of gastric mucosa with xiao wei yan powder].[Article in Chinese] by Liu XR1, Han WQ, Sun DR. (PubMed)

Cabbage Processes Immunomodulatory Activity

By Kyle J. Norton

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

In other words, the immunomodulatory activity involved antimicrobial agents is to modulate the genes involved in immune reactions, or of the neurohormonal system which regulates immune functions and any toxic or immunotoxic effects such as allergic reactions or destruction of immune effectors, that may cause harm to the body or interfere with the body normal function.

The overactive immune system is a class of autoimmune diseases or chronic inflammatory diseases caused by the immune system attacking the body's tissue, including rheumatoid arthritis (RA), rheumatoid arthritis, systemic lupus erythematosus,.... and multiple sclerosis.

The widespread chronic inflammatory diseases in modern society are a burden to humans because of life-long debilitating illness, increased mortality and high costs for therapy and care.

The underactive or weakened immune system caused by a primary immune deficiency or acquired immune deficiency.may not protect the body against foreign organisms in initiated infection.

Sometimes, temporarily weaken the immune system may also be caused by the intake of certain conventional medicine, such as chemotherapy or drugs that treat cancer.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings a natural wholefood for the improvement of immune functioning, researchers examined the immunomodulatory effect and mechanism of Lactococcus lactis A17 (A17), isolated from Taiwan fermented cabbage, on ovalbumin (OVA)-sensitized mice.

In live (A17-A) and heat-killed A17 (A17-H) orally administered to OVA-sensitized BALB/c mice effects, researchers found that  live (A17-A) and heat-killed A17 (A17-H) induced allergic effects by increasing the

* B-cell response that was modulated by diminishing IgE production and raising OVA-specific IgG2a production and the T-cell response that was modulated by increasing IFN-γ production and decreasing IL-4 production.

* Furthermore, the mRNA expression of NOD-1, NOD-2, and TLR-4 associated with the expression of inflammation and infection was down-regulated by A17.

In other words, a naïve Lactococcus lactis A17 strain exerted a significant immunomodulatory activity against allergic diseases via oral administration

Based on the results, researchers wrote, "the ameliorative effects of A17 may be caused by modulating NOD-1 NOD-2, and TLR-4 expression".

Taken altogether, cabbage processes immunomodulatory activity, pending to the confirmation of the larger sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALB/c Mice by Mei HC1, Liu YW, Chiang YC, Chao SH, Mei NW, Liu YW, Tsai YC. (PubMed)

Herbal Coltsfoot(Tussilago farfara) Protects the Neurons Against Oxidative Injury

By Kyle J. Norton

Amyloid beta (Aβ or Abeta) is the main component of the amyloid plaques that cause the gradual death of neurons, leading to the onset of Alzheimer's disease.

Alzheimer's disease is a common form of dementia or neurodegenerative disease found in the elderly.

Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

According to the statistics, the disease is most prevalent in the elderly. Approximately 5.7 million Americans of all ages are living with Alzheimer's. 15.9 million family caregivers provide an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.

 Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic preposition. Patients with such mutated genes on chromosomes 21, 14, and 1are virtually guaranteed to develop the disease.

More precisely, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.

Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.

Compared to dementia, neurological disorders are a class of brain disease associated with reduced function of the brain, depending on the region of the neurons that were affected.

Dr. Rudolph E. Tanzi said, "The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD".

And, " These four genes account for 30%–50% of the inheritability of AD".

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of hypercholesterolemia, researchers examined the anti-inflammatory effect against oxidative injury of Tussilagone (TSL), isolated from the flower of buds of Tussilago farfara (Compositae) by examing the quinone reductase cellular detoxification in Hepa1c1c7 cells.

According to the results of the analysis, herbal coltsfoot decreased the activity tert-butyl hydroperoxide(t-BHP), an organic peroxide widely used in a variety of oxidation processes, -induced ROS production and cell death, through its potent antioxidant.

Furthermore, NRF2, that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation showed to upregulate the detoxifying enzymes NAD(P)H quinone dehydrogenase 1(NQO1) and heme oxygenase-1(HO-1) against oxidative stress.

Moreover, (ERK1/2), the mitogen-activated protein kinase superfamily that can mediate cell proliferation and apoptosis was also mediated by the expression of NRF2.

In other words, coltsfoot showed a strong activity to attenuate t-BHP-induced ROS and Nrf2 pathway activation to inhibit the overexpression of reactive oxidative species induced free radical domino's activities against HepG2 cells from oxidative stress and associated damage.

Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with oxidative injury, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury by Lee KM1, Kwon TY1, Kang U2, Seo EK2, Yun JH3, Nho CW3, Kim YS. (PubMed)

Oleanolic Acid, The Antioxidant That Inhibits the Onset of Diabetes in Vivo

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids. 

Traditional Chinese medicine views the pancreas as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Hyperglycemia, a hallmark of diabetes has been found to induce diabetics complications, including neuropathy, nephropathy, and retinopathy). ...

Oleanolic acid is a phytochemical in the subclass of triterpenoid, belongings to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant that processes anti-chronic disease activity researchers examined the hematological effects of oleanolic acid (OA) in streptozotocin- (STZ-) induced diabetic rats.

The study included animals that were separated into five groups; the nondiabetic group (ND), the diabetic control group (DC), and the treatment groups of insulin (170 μg/kg, s.c), metformin (500 mg/kg, p.o), and OA (80 mg/kg, p.o). OA was administered orally twice a day.

According to the results of the analysis,
* Untreated diabetic rats exhibited hyperglycemia, elevated glycated hemoglobin (HbA1c), oxidative stress, and a reduced erythropoietin (EPO) concentration when compared to ND rats.

* The administration of OA attenuated hyperglycemia, HbA1c, and EPO concentrations compared to DC rats.

* Furthermore, OA also decreased the blood glucose concentration, HbA1c, and improved EPO concentrations associated with a notable increase in red blood cell (RBC) count and other RBC indices.

* Moreover, OA increased the antioxidant status of the RBCs with a concomitant decrease in oxidative stress.

Collectively, researchers said, "These findings suggest that OA improves diabetes-induced hematological changes caused by hyperglycemia and attenuates the progression of cardiovascular complications in DM individuals".

Taken altogether, oleanolic acid may be considered a remedy for the prevention and treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers by Baloyi CM1, Khathi A1, Sibiya NH2, Ngubane PS. (PubMed)

Angelica Sinensis, the Natural Anticancer Herbal Remedy

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer".

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The prevalent factors associated with the risk of cancer are age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression.

Cancers are the second leading cause of death worldwide besides heart diseases. Believe or not, 1/4 of cancers death are due to lung cancer.

On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined Radix Angelica Sinensis (Danggui in Chinese) is widely used in traditional Chinese medicine (TCM). N-butylidenephthalide (BP), a bioactive compound in Dangui, is a potential antitumor agent for various cancer types.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the experimental results,

* Danggui users were found to have an increased survival rate when compared with Danggui nonusers (log-rank test p = 0.002).

* The use of Danggui highly associated with decreased mortality (the adjusted hazard ratio (HR) of Danggui user was 0.72 [95 % CI, 0.57-0.92] (p = 0.009).

* The in vitro results showed that BP inhibited gastric cancer cell proliferation, and triggered cellular apoptosis depending on the activation of the mitochondrial apoptotic pathway.
* According to the RNA-seq analysis, BP induced an increase of REDD1 expression that inhibits mTOR signaling, thus inhibiting gastric cancer growth.

* BP suppressed the growth of AGS xenografts tumor in vivo.

Based on the results, researchers suggest, "Danggui can prolong the survival rate of gastric cancer patients in Taiwan. BP caused gastric cancer cell death through the activation of mitochondria-intrinsic pathway and induced the REDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells".

Taken altogether, Dandelion may be considered anti-cancer activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition by Liao KF1,2, Chiu TL3,4, Huang SY5, Hsieh TF3,6, Chang SF7, Ruan JW8, Chen SP9, Pang CY10,11, Chiu SC. (PubMed)

Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation

By Kyle J. Norton

Cancer is a class of diseases associated with irregular cell growth on the tissue of the specific organ.

Most cases of invasive cancer can spread to other organs in the body via lymph or blood.

According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).

The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.

In cancer cells, due to the alternation of DNA, can grow indefinitely.

Cancer cell metastasis is the process that cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

Through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interactions.

In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines to the site of the damage. The inflammatory cytokines not only play a critical role in stopping the stimuli from entering into the body but also speeds up the wound healing through growth factors.

The innate immune system also can destroy the damaged cells such as cancer cells through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53.

Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding natural food for the prevention and treatment of cancer proliferation, researchers examined the anti-metastatic activities of polysaccharides in broccoli, including BCE-I mainly consisted of galactose and arabinose, whereas BCE-II mainly consisted of galacturonic acid and rhamnose, and BCE-III mainly consisted of rhamnose and galactose.

According to the results of the analysis, 

* BCE-I showed the greatest enhancement the pro-inflammatory proteins such as tumor necrosis factor-α, interleukin (IL)-12, and IL-6 secretion by stimulating murine peritoneal macrophages in the immune response.

* Furthermore, intravenous (i.v.) administration of BCE-I enhanced the lethal activity on YAC-1 tumor cells significantly and dose-dependently in an ex vivo by exhibiting the natural killer (NK) cells.

* On lung metastasis of Colon26-M3.1 carcinoma cells, prophylactic i.v. and oral administration of BCE-I significantly and dose-dependently inhibited lung metastatic activity.

In other words, the inhibitory activity of BCE-1 on lung metastasis are depending on the NK cell function in GM1 activity.

Based on the results, researchers wrote, " BCE-I has potent antitumor metastatic activity, and that its anti-metastatic activity has relevance to the stimulation of NK and other immune cells".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the inhibiting the cancer cell metastasis, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Rhamnogalacturonan-I-Type Polysaccharide Purified from Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation by Kwak BS1, Hwang D2,3, Lee SJ1, Choi HJ4, Park HY5, Shin KS. (PubMed)

Herbal Eyebright ( Euphrasia) Protects the Human Corneal Cell Integrity

By Kyle J. Norton

Human Corneal Epithelial Cells (HCEpC) isolated from the epithelium of the Human Cornea have been used in a wide range of basic ocular studies involving problems associated with the cornea.

The corneal epithelium is the barrier function that plays a critical role to defend against many types of injury, trauma, or infection.
The cornea accounting for approximately two-thirds of the eye's total optical power covers,
* The iris

the iris (plural: irides or irises) is a thin, circular structure in the eye that controls the diameter and size of the pupil to allow the amount of light reaching the retina.
* The pupil
The pupil is a black hole located in the center of the iris that allows light to reach the retina
* The anterior chamber
The anterior chamber (AC) is space in the eye that is behind the cornea and in front of the iris.

In other words, the cornea, with the anterior chamber and lens, refracts light, with the cornea

Corneal disease happened mostly in the aging population, is a medical condition that can cause clouding, distortion, scarring and eventually blindness.

Other common causes of corneal diseases are infection, cataract, genetic proposition, use of contact lense, eye injury, and diseases, including retinitis pigmentosa, retinopathy of prematurity, and vernal keratoconjunctivitis, Ehlers-Danlos syndrome, and Down syndrome.

On finding a natural ingredient for the prevention and treatment of eye inflammation, scientists examined the protective effects of eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells.

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe. 

The plant has been used in traditional and herbal medicine to treat eye infection and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

According to the tested analysis of HCEC-12 cells exposed to UVB radiation and treated with the eye drops at various concentrations,
* The administration of eye drops protect corneal epithelial cells from UVB-induced cell death and ameliorated the wound healing.

* The eye drops exhibited a strong antioxidant activity in the inhibition of ROS expression and protein and lipid oxidative damage.

* Furthermore, the eye drops also exerted anti-inflammatory activities by decreasing the proteins in activating the pro-inflammatory cytokines such as COX-2, IL-1β, iNOS expression,

* Moreover, the eye drops counteracted UVB expression by inducing antioxidants expression of glutathione synthetase (GSS) and superoxide dismutase 2(SOD-2) expression and restoring the HO-1 levels to control levels.

Based on the results, researchers suggest, "These findings suggest that an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts exerts positive effects against UVB induced oxidative stress and inflammation and may be useful in protecting corneal epithelial cells from UVB exposure".

Taken altogether, Dandelion may be considered a remedy for the protection of human corneal cells, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pharmacological activities of an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells by Bigagli E1, Cinci L1, D'Ambrosio M1, Luceri C2. (PubMed)