Devil's claw (Harpagophytum procumbens) May Induce Interaction with Drugs When Used for the Treatment of Neurological Disorders

By Kyle J. Norton

Neurological disorders are medical conditions characterized by any disorder of the nervous system caused by structural, biochemical or electrical abnormalities.

There are many forms of neurological disorders. The most common types of the disease include neurodegenerative disease, such as Alzheimer's disease (AD) and Parkinson's disease, epilepsy. multiple sclerosis and Migraines.

According to the Medical press, globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy, etc) has increased substantially over the past 25 years.

These may be results of over 25 years of economic expansion that have increased the living standard of billion of people in the Southeast Asian region.

The WHO in the evaluation of neurological disorder wrote, "Neurological disorders contribute to 92 million disability-adjusted life years (DALYs) in 2005 projected to increase to 103 million in 2030 (approximately a 12% increase). While Alzheimer's and other dementias are projected to show a 66% increase from 2005 to 2030".

Where one DALY represents the loss of the equivalent of one year of full health.

Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease and Alzheimer's disease and stroke.

Alzheimer's disease (AD) is a most common neurodegenerative disease in the elderly in the Western world, associated with the worsening of memory, thinking and behavior that severe enough to affect language communication, memory, lifelong hobbies or social life

On finding a natural ingredient for the prevention and treatment of neurodegenerative diseases, scientists examined the neuroprotective effects of Devil's claw.

Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa. 

The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.

According to the active ingredients studied in laboratory and clinical settings, Devil's claw showed a promising natural therapeutics with anti-oxidative and anti-inflammatory salutations in protecting neuron integrity.

However, despite the promising and safe therapeutic benefits of CAM/herbal medicines, including Devil's claw, there exists a possible risk when combining them with prescription drugs.

In other words, Devil's claw may interact with drugs that have shown changes in blood pressure, hepatotoxicity, seizures, etc. when used in a combination.

Based on the results, researchers suggest, "Certainly, extensive work is needed to make sure that patients should take a regimen of protective and restorative therapy under an experienced healthcare professional".

Taken altogether, Devil's claw may be considered a remedy for the treatment of neurological disorders, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Natural or Plant Products for the Treatment of Neurological Disorders: Current Knowledge by Parvez MK. (PubMed)

Herbal Enchinanea Inhibits the Pathogenic E. Coli Infection

By Kyle J. Norton

Bacterias are a class of microorganisms consisted of a single cell with a simple internal structure with a number of different shapes.

Not all bacterias are harmful to humans. Some are essential to human life, with benefits related to improve the digestive function, prevent overexpression of harmful disease-causing bacteria, and the synthesis of essential nutrients and vitamins.

Believe it or not, the human gut contains over 10 trillions of bacterias including at least 1000 different species of known bacteria with more than 3 million genes.

In a healthy individual, the levels of microorganisms in the gut are balanced.

The gut microbiota plays a critical role in breaking down foods that stomach and small intestines cannot digest, stimulating the production of vitamin K and D, protecting the intestinal against damage caused by bad bacteria and increasing the immune functioning.

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.

The most common diseases associated with pathogenic Escherichia coli are cholecystitis, bacteremia, cholangitis, urinary tract infection (UTI), and traveler's diarrhea.

Conventionally, most cases of infectious diseases except those caused by viruses are treated by antibiotics.

Echinacea also is known as purple coneflowers, is a flowering plant of the genus Echinacea, belongings to the family Asteraceae, native to eastern and central North America. The herb has been used in traditional and herbal medicine to treat or prevent colds, flu, infections by stimulating the immune function, etc.

On finding a potential phytochemical for the treatment of infectious diseases, researchers examined the impact of dietary supplementation with Echinacea purpurea (EP) in broiler chickens infected by pathogenic E. coli.

The study included eighty-one-day-old chicks of both sexes, commercial Hubbard chicks, that were divided into 4 groups.
* The first was kept as normal control.
* The second was supplemented by EP (5 mg/kg feed) from the first day to the end.

* The third was infected orally by 1 ml E. coli O78 at 107 CFU intra-crop at 7 days old. 

* The fourth group was supplemented by EP and infected by the E. coli O78 as previously described.

According to the analysis.
* Compared to E. coli-infected chicks that disclosed severe symptoms with mortality 30%, the infected and EP supplemented group showed less clinical symptoms and 15% mortality.
* EP-supplemented groups showed a significant improvement in their body weight compared to the infected group.

* More importantly, E. coli-infected chickens revealed a significant drop in lymphocytes' number with a significant elevation in monocyte and heterophils with non-significant changes in total leucocyte count when matched with group, while the fourth group revealed non-significant changes in total leucocyte with a significant drop in heterophils and monocyte and a significant elevation in the lymphocytes matching with the 3rd group.

* Furthermore, serum biochemical markers of the liver, kidneys, and immunological parameters showed severe adverse alterations associated with E. coli infection.

After talking about other factors into account, researchers said, "Dietary supplementations with Echinacea purpurea improve the final body weight and immune response of non-infected chicks and have a respectable effect for facing E. coli infection".
And "EP improves hematological and serum biochemical adverse effects occurred by E. coli infection. Histopathology of liver, kidneys, intestines, and spleen confirms these alterations".

Taken altogether, herbal Enchinanea may be considered adjunct therapies in the treatment of infectious diseases induced by E. coli, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of dietary supplementation with Echinacea purpurea on growth performance, immunological, biochemical, and pathological finding in broiler chickens infected by pathogenic E. coli by Hashem MA1, Neamat-Allah ANF2, Hammza HEE3, Abou-Elnaga HM. (PubMed)

Dandelion(Taraxacum officinale) Inhibits the Onset of Hyperlipidemia in Vivo

By Kyle J. Norton

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

The condition is normally known as high blood cholesterol in the general population.

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, produces vitamin D and steroid hormones.

High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million American and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

The healthy ratio of low-density lipoprotein (LDL)/high-density lipoprotein (HDL) is ant numbers that are less than 4.

There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.

Some researchers suggested the promotion of a high-fat diet over the past decades may be one of the silent cause of hyperlipidemia in the Western world.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of high blood cholesterol, scientists examined the possible hypolipidemic and antioxidative effects of dandelion root and leaf in rabbits fed with a high-cholesterol diet.

The study included a group of 28 male rabbits that were divided into four subgroups; a normal diet group, a high-cholesterol diet group, a high-cholesterol diet with 1% (w/w) dandelion leaf group, and a high-cholesterol diet with 1% (w/w) dandelion root group.

After the treatment period,  researchers found that dandelion root and leaf positively changed plasma antioxidant enzyme activities and lipid profiles in cholesterol-fed rabbits.

In other words,  dandelion root and leaf exerted potential hypolipidemic and antioxidant effects in animals fed with a high-fat diet.

Furthermore, dandelion root and leaf also protected against oxidative stress linked atherosclerosis and decrease the atherogenic index.

Taken altogether, dandelion may be considered an antioxidant remedy for the prevention of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits by Ung-Kyu Choi,1 Ok-Hwan Lee,2,* Joo Hyuk Yim,3 Chang-Won Cho,3 Young Kyung Rhee,3 Seong-Il Lim,3 and Young-Chan Kim. (PMC)
(2) C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia by Charles Desmarchelier,1 Christoph Dahlhoff,1,2 Sylvia Keller,3 Manuela Sailer,1Gerhard Jahreis,3 and Hannelore Daniel. (PMC)

Coltsfoot(Tussilago farfara) Inhibits the Parameters Associated with the Onset of Sepsis

By Kyle J. Norton

Sepsis is a medical condition caused by chemicals released into the bloodstream to fight the infection that triggers inflammation throughout the body as a result of severe infection. 

According to the study by the University of Utah, the disease is the commonest cause of admission to medical ICUs across the world. 

Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis.

Most common symptoms of sepsis are

* Chilly periphery, fever, jaundice, platelet, and hemoglobin

* Abnormalities of blood pressure, respiration, temperature, and heart rate, and less well-known changes in heart rate variability

* Significantly decreased urine output but accumulative fluid balance had a weak correlation with delta sequential organ failure assessment score (r = 0.32, P = 0.001) and lung injury score (r = 0.13, P = 0.02) and negative correlation with PaO2/FIO2 ratio (r = -0.28, P = 0.001).

* Abrupt change in mental status, difficulty breathing and abnormal blood circulation.

According to the statistics from the CDC, approximately 1.7 million adults in America were infected by sepsis, leading to the death of 270,000 Americans every year.

Sadly, 1 in 3 patients who die in a hospital has sepsis.

Early recognition of sepsis and septic shock in children relies on obtaining an attentive clinical history, accurate vital signs, and a physical examination focused on mental status, work of breathing, and circulatory status, according to the study by the University of Colorado School of Medicine.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of life-threatening infection, researchers examined the Tussilagone, extracted from Tussilago farfara inhibitory effects on puncture (CLP)-induced mouse model of sepsis.

According to the tested differentiation, the extracts at 1 mg/kg and 10 mg/kg showed a significant effect on decreased mortality and lung injury in CLP-activated septic mice.

Enzyme and proteins associated with the production of inflammatory expressions such as cyclooxygenase (COX)-2 and TNF-α in tested septic mice were also attenuated by Tussilago administration. 

Furthermore, CLP induced expression of nitric oxide, prostaglandin E2, TNF-α and HMGB 1 associated with inflammatory cytokines in the serum of the septic mice was also suppressed the administration of the extract.

Based on the findings, researchers said, "Overall, Tussilago exhibited protective effects against inflammation and polymicrobial sepsis by suppressing inflammatory mediators possibly via the inhibition of NF-κB activation and the MAP kinase pathway.".

Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with sepsis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Thyroid Disease: Euthyroid sick syndrome as a result of Sepsis - The Symptoms by Kyle J. Norton
(2) Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced Septic
Mice by Kim YK1, Yeo MG2, Oh BK3, Kim HY4, Yang HJ5, Cho SS6, Gil M7, Lee K. (PubMed)

Herbal Angelica May Reduce the Mortality Rate in Patients with Sepsis

By Kyle J. Norton

Sepsis is a condition caused by chemicals released into the bloodstream to fight the infection that triggers inflammation throughout the body as a result of severe infection(a)(b). according to the study by the University of Utah, sepsis is the commonest cause of admission to medical ICUs across the world.

Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis(c).

The most common risk factors associated with the prevalent factors of sepsis, term infants, while very low birth weight (VLBW) and preterm infants, obesity, operative vaginal delivery and age <25 years, elderly, patient in intensive care and with the weakened immune system, invasive devices, and alcoholism.

Diseases associated with Sepsis are

* Staphylococcal infections
Preterm infants are especially susceptible to late-onset sepsis that is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality(24).

* Elevated central venous pressure
Elevated central venous pressure is associated with impairment of microcirculatory blood flow in sepsis(25).

* Neonatal cellulitis
There is a report of a case of late-onset neonatal invasive group A streptococcal disease characterized with rapidly progressing cellulitis and development of sepsis(26).

* Methicillin-resistant Staphylococcus aureus
There is a report of the spectrum of community-acquired S. aureus infections and to compare the patients infected with methicillin-susceptible or methicillin-resistant strains among patients aged <20 years. Overall, 90 cases of community-acquired S. aureus were detected in an 11-year period(27).

* Bladder infection
Bladder bacteria is a common but unique cause for sepsis(28).

* Urinary tract infection
In the study to evaluate the effectiveness of Lactobacillus GG supplementation in reducing the incidence of urinary tract infections (UTIs), bacterial sepsis and necrotizing enterocolitis (NEC) in preterm infants, found that seven days of Lactobacillus GG supplementation starting with the first feed is not effective in reducing the incidence of UTIs, NEC, and sepsis in preterm infants. Further studies are required to confirm our results in lower birth weight populations(29).

On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the effects of Xuebijing injection (XBJ), a Chinese patent medicine on sepsis.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the search of medical literature in Embase, PubMed, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP) and the Wanfang database from inception to June 6, 2017, including relevant RCTs comparing XBJ combined with RT and RT alone for sepsis, 

* 1602 records and 16 RCTs (1144 patients) identified suggested that the combined therapy reduced 28-day mortality and body temperature.

* WBC count improved with combined medication at high dosages (one study included, 40/1144, MD -8.00, 95% CI -10.18 to -5.82) with no reduction at moderate dosages.

* However, moderate-quality evidence indicated positive results with low dosages.

Based on the results, researchers suggest, "This study suggested that supplementation with XBJ in addition to regular treatment may improve the 28-day mortality rate, APACHE Ⅱ scores, WBC count and body temperature of sepsis patients without serious adverse events".

Taken altogether, angelica used combined with other herbal medicines may be considered a remedy for the treatment of sepsis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials by Li C1, Wang P2, Zhang L3, Li M4, Lei X5, Liu S6, Feng Z7, Yao Y8, Chang B9, Liu B10, Shang H. (PubMed)
(2) Thyroid disease: Euthyroid sick syndrome as a result of Sepsis - Diseases associated with Sepsis by Kyle J. Norton

Cranberry, a Natural Gingipain Inhibitor

By Kyle J. Norton

Periodontitis is a severe stage of gingivitis that damages the soft tissue and destroys the bone that supports your teeth, leading to teeth loosen or tooth loss.

Systemic diseases are a group of condition that affects other parts of the body, or even the whole body.

The most common symptomatic disorders are high blood pressure that affects the brain and diseases associated with the circulatory system or systemic disease flu that affects the entire body.

An infection in the bloodstream is called a systemic infection.

Most common systemic diseases are

* Rheumatoid arthritis 

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1). According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions. 

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation. 

 * Atherosclerosis

Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

* Sickle cell anemia

Sickle cell anemia (SCD), a genetic preposition form of anemia is a condition associated with not enough healthy red blood cells to carry adequate oxygen throughout your body.

The red blood cells in sickle cell anemia patines are rigid and sticky with the shapes of sickles or crescent moons.

The normal red blood cells live for about 120 days compared to the sickle cells that die in 10 to 20 days. In other words, the inability of the body to replace the cell that dies rapidly with new blood cells is a cause of sickle cell anemia. 

Other systemic diseases may include diseases of the heart, malignant neoplasms, cerebrovascular diseases, chronic obstructive pulmonary disease, pneumonia, influenza, diabetes mellitus, trauma, Alzheimer's disease, renal diseases, septicemia, and liver diseases.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases that affect part or whole body, researchers investigated the cranberry and rice extracts effect on gingipains associated with
periodontitis and systemic diseases.

According to the tested results, the administration of cranberry and rice extracts interfere with gingipain activity and prevent the growth and biofilm formation of periodontopathogens.

In other words, the tested extract showed a gingipain inhibition that represents a novel approach to treat and prevent periodontitis. 

The cranberry rice extract as a gingipain inhibitor may also help treat systemic disorders that are associated with periodontitis, including cardiovascular disease, rheumatoid arthritis, aspiration pneumonia, pre-term birth, and low birth weight.

Taken altogether, cranberry combined with other herbal medicine may be considered a remedy for the treatment of systemic diseases in patients with periodontitis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)
(2) The Holistic Prevention, Management and Treatment of Rheumatoid Arthritis back by Research and Studies of Renowned Institutions by Kyle J. Norton

Herbal Cramp Bark (Viburnum opulus), the Potential Acetylcholinesterase Inhibitor

By Kyle J. Norton

The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).

Acetylcholinesterase (AChE) is the primary enzyme that hydrolyzes the neurotransmitter acetylcholine to choline and acetate.

Altered levels of ACh in the nervous system have been found to induce several neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington, depending on the affected areas.

Butyrylcholinesterase (BuChE) enzyme plays a minor role in regulating brain acetylcholine (ACh) levels.

A cholinergic neuron is a nerve cell which mainly is used by  the neurotransmitter acetylcholine (ACh) to send its messages

Impairment of the cholinergic neuronal system in the brain was involved in the underlying event of cognitive impairment.

Cholinesterase inhibitors (ChEI) has been used for the treatment of Alzheimer's disease (AD).

Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.

On finding a potential herbal medicine for the prevention and treatment of associated with neurodegenerative diseases, researchers examined ethyl acetate, methanol, and water extracts prepared from the branches, leaves, and fruits of Viburnum opulus and Viburnum lantana along with salicin on acetylcholinesterase (AChE) inhibitory and antioxidant activities.

In vitro, according to the results from an enzyme-linked immunosorbent assay, the leaf methanol extract of V. opulus displayed a significantly high inhibitory effect against AChE at 50, 100, and 200 μL/mL concentrations of 57.63%, 87%, and 93%, respectively compared to other extracts.

In other words, the leaf methanol extract of V. opulus showed the highest protective activity against the disruption of neuron in the induction of neurodegenerative diseases linearly in a doses dependent-manner.

Compared to Viburnum opulus, the extracts of V. lantana exerted higher antioxidant activity.

Taken altogether, cramp bark(Viburnum opulus) leaves may be considered a functional acetylcholinesterase inhibitor herb medicine for the prevention and treatment of neurodegenerative diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents by Erdogan-Orhan I1, Altun ML, Sever-Yilmaz B, Saltan G. (PubMed)