Friday, 21 February 2020

Onion and Garlic, the Natural Anti-Endometrial Cancer Functional Foods

By Kyle J. Norton

The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particularly to the menstrual cycle.

Endometrial cancer is a late adulthood cancer in which the cells of the endometrial lining of the uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA.  

At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.

Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.

The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity and the use of hormone therapy are some of the major prevalent risk factors associated with endometrial cancer.

It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in the US are diagnosed with the disease.

Women who carry certain mutation genes, such as BRCA1 or the BRCA2 are associated with an increased risk of endometrial cancer.

Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.

The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity and the use of hormone therapy are some of the major prevalent risk factors associated with endometrial cancer.

Depending on the stage and grade of cancer, chemotherapy such as Doxorubicin, Cisplatin. Paclitaxel, Carboplatin, Topotecan may be necessary after surgery with certain side effects. 

On finding a potential plant that processes anti-cancer activity researchers compared the relationship between onion and garlic intake and endometrial cancer, using data from an Italian case-control study.

According to the results of validated and reproducible FFQ of the multi-center case-control study of 454 endometrial cancer cases and 908 controls, who were admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions.

Compared with non-users, the OR of endometrial cancer for successive categories of onion intake were 0.94 (95% CI 0.72, 1.21) for <2 portions/week and 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week.

In other words intake of onion showed a significant inverse trend in the risk of endometrial cancer. The OR for an increment of one portion (i.e. 80 g) of onions per week was 0.81 (95% CI 0.70, 0.95).

Furthermore, the OR of garlic for successive categories of intake were 0.89 (95% CI 0.68, 1.15) for intermediate use and 0.62 (95% CI 0.42, 0.92) for high use, with a significant inverse trend in risk (P = 0.02).

Collectively, researchers said, "Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer".

Taken altogether, garlic and onion may be considered functional foods for the prevention and treatment of endometrial cancer pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Allium vegetables intake and endometrial cancer risk by Galeone C1, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. (PubMed)

Healthy Food Leeks, the Promising Anticancer Veggie

By Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved in the onset of cancer.

However, most people with some of the aforementioned risk factors have never developed cancer.

Cancers are the second leading cause of death worldwide besides heart diseases.

The most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.

Believe it or not, 1/4 of cancers death are due to lung cancer.

Depending on types of cancer, people with cancers may experience general and specific symptoms.
Some researchers suggested that the risk of cancers in obese individuals may correlate to the promotion of the Western diet over the past few decades.

Leek is a genius of Allium, belonging to the vegetable family vegetable Alliacaea, the same as onion and garlic. Leeks are easy to grow from seed and usually reach maturity in the autumn months, and have few pest or disease problems.

On finding a potential plant that processes anti-tumor growth activity researchers compared the anticancer properties various sulfur and organic compounds like S-allyl mercaptocysteine, quercetin, flavonoids, and ajoene found on leek on cancer.

According to the analysis,
* These compounds with various mechanisms such as hindering cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells.

* Similar to garlic and onion, other species such as leeks have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents.

Moreover, the study on anticancer effects of onion and leek extracts on MCF-7 human breast cancer cell cultured in complete media at 37 °C and subjected to different treatments that involved varying concentrations (10, 50, and 100 μg/mL) of onion and leek extracts for 24, 48, and 72 h of incubation suggested that 
* The water leek extract proved to be the most effective extract at 50 μg/mL, whereby it showed a significant inhibition ability due to the presence of entadamide A-β-D-glucopyranoside.

* Both extracts induced cell death probably was also associated with the presence of other bioactive compounds.

Taken altogether, leeks may be considered a functional food for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparative Study of Onion (Allium cepa) and Leek (Allium ampeloprasum): Identification of Organosulphur Compounds by UPLC-QTOF/MS and Anticancer Effect on MCF-7 Cells by Zamri N1, Hamid HA. (PubMed)
(1) Allium vegetables for possible future of cancer treatment by Asemani Y1, Zamani N2, Bayat M1, Amirghofran Z. (PubMed)

Healthy Foods Broccoli does NOT have a Short Term Benefits on Asthma

By Kyle J. Norton

Respiratory Disease is a medical condition which affects the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove the carbon dioxide and other waste gases from the body.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.

In 2017, 28,600 Canadians were diagnosed with lung cancer, represented 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.

Besides episodes of wheezing, coughing, chest tightness, and shortness of breath, patients with asthma also experience symptoms of reversible airflow obstruction and bronchospasm.

Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.

Asthma in some cases can interfere with daily activities and may lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episode and severity of the attacks.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.

Believe it or not, African-Americans in the U.S. die from asthma at a higher rate than people of other races or ethnicities.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of respiratory diseases, researchers examined the effect of Broccoli sprouts (BS) on airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen.

A double-blind, placebo-controlled, randomized trial to compare the effects of BS with placebo (alfalfa sprouts [AS]) on airway inflammation and markers of OS included 40 adults (aged 18-50 years) who were randomized to eat either (a) 100 g of BS daily or (b) 100 g of AS daily for 3 days.
According to the tested analysis,
* BS ingestion for 3 consecutive days did not reduce FeNO in asthma, despite causing a marked increase in serum SFN concentrations (21 vs 22 parts per billion, P = .76).

* Furthermore, BS administration did not induce cytoprotective antioxidant genes in either PBMCs or nasal epithelial cells, 

* Moreover, BS consumption did not reduce OS and inflammatory markers or improve lung function.

In other words, short term interference of BS showed  no improvement of the symptoms on asthmatic patients


Based on the results, researchers wrote, " Ingestion of the whole BS for 3 days does not appear to improve eosinophilic pulmonary inflammation, inflammatory and OS biomarkers, or clinical features of asthma among atopic adults with asthma despite resulting in a marked increase in serum SFN levels."

And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics by Sudini K1, Diette GB2, Breysse PN3, McCormack MC2, Bull D4, Biswal S5, Zhai S4, Brereton N6, Peng RD7, Matsui EC. (PubMed)

Thursday, 20 February 2020

Potato (Solanum) a Natural Antibacterial Functional Food

By Kyle J. Norton

Infectious diseases are a class of conditions caused by the invasion of pathogenic microorganisms, such as bacteria, viruses, parasites or fungi.

Bacteria is a type of biological cell consisted of a single cell with a simple internal structure.

Out of millions of bacteria presented in this world, only a hundred of them cause infectious diseases. And, most bacteria that cause large-scale disease in human history may be closed to extinction.

In contrast to general belief, most bacteria live as independent cells, they share the basic characteristics of all living things, they breathe, metabolize, produce waste, and maintain a membrane potential.

However, bacteria do not process a nucleus in which their DNA is separated from the rest of the cell.

In the differentiation of bacteria, one must know that not all bacteria are bad. Some bacteria found in the digestive tract have been found to aid digestion and prevent the imbalance of bad and good bacteria. In other words, most bacteria are harmless.

The most common diseases caused by bacteria include strep throat, urinary tract infections, and tuberculosis.

Infection occurs when the bacteria successfully invade the body and start to multiply. Most cases of infectious diseases caused by bacteria are treated with antibiotics.

And, most cases of infectious disease are transmitted by airborne you can get sick if you breathe into the air that carries infectious bacteria in air particles, vector-borne if you are stunk by the insect that the bacteria and vehicle-borne if you are eating food or carrying the materials contaminated by the bacteria.


Potato is a genus Solanum, belongs to the family Solanaceae. It is a good source of protein and according to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potato. It now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.


On finding a potential plant that processes anti-infectious property, researchers evaluated the antibacterial and cytotoxic activity of a new experimental tooth based on Solanum tuberosum "Tocosh" on the cell lines 3T3 and DU145.

According to the tested analysis
* Solanum tuberosum (toosh) was not cytotoxic because it only had one CC50 at the concentration of 0.26927 mg/mL and 0.26845 mg/mL for the cell lines 3T3 and DU145, respectively.

* However, tocosh toothpaste (TD) has an antibacterial effect against S. aureus and S. mutans.

In other words,  Solanum tuberosum showed no effects to induce cell death in the tested cancer cell lines but exerted a strong activity against certain oral bacterial strains.

Collectively, researchers said, "This research has great potential for clinical use because this new dentifrice has antimicrobial activity against different oral germs".

Taken altogether, potatoes may be considered a functional food for the prevention and treatment of infectious diseases, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Development of New Experimental Dentifrice of Peruvian Solanum tuberosum (Tocosh) Fermented by Water Stress: Antibacterial and Cytotoxic Activity by Mayta-Tovalino F1, Sedano-Balbin G2, Romero-Tapia P2, Alvítez-Temoche D3, Álvarez-Paucar M4, Gálvez-Calla L5, Sacsaquispe-Contreras S. (PubMed)

Fermented Soy, A Possible Anti-Breast Cancer Functional Food

By Kyle J. Norton

Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, most cases of breast cancer start in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases of breast cancer that start in other areas of the breast

The cause of breast cancer is the result of the alternation of DNA of the cells in the breast.

According to statistic, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone

At the advanced stage, breast cancer cells caused by the alternation of DNA can travel far away from the primary site to infect other healthy tissue and organs.

Most patients at the early may have a lump when touching with no symptoms.

Patients who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.

However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.

According to statistics, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Detection of tumorigenesis through self-observation is still the best approach to discover breast cancer in an early stage.

The risk of getting invasive breast cancer during the lifetime of a woman is 1/8. As of today, there are more than 3.1 million breast cancer survivors in the US.

The 5 years of the survival rate of localized breast cancer are closed to 100%.

The risk factors of breast cancer can be divided into 2 groups
* Preventable risk factors include exposure to ionizing radiation, hormone replacement therapy, use of oral contraceptives, alcohol, being obese and physical inactivity.

* Unpreventable risk factors include family and personal history, age, race, genetic preposition, dense breast, and reproductive history.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant that processes anti-tumor activity researchers examined the effect of fermented soy milk beverage on breast cancer.

According to the results of the analysis,
* Selected fermented soy milk showed a strong impact on breast cancer through its estrogenic and the anti-estrogenic -dependent activity.

Some probiotic strains reportedly release bioactive metabolites through the fermentation of milk, and the released molecules can prevent murine breast tumor growth by stimulating an immune response.

* Fermented soy milk beverage containing Lactobacillus acidophilus, Lactobacillus bulgaricus, Streptococcus lactis, or Bifidobacteria inhibited the growth of estrogen-receptor-positive MCF-7 human breast cancer in mice, associated with cytotoxicity generated by the reactive oxygen species.

* In vivo, the fermentation of soy milk using Bifidobacterium breve increased the content of isoflavone aglycone, and this fermented soy milk beverage inhibited rat mammary carcinogenesis.

Collectively, researchers said, "APPH can, therefore, be considered as an efficient therapeutic agent to ameliorate high-fat diet-related liver damages".

Taken altogether, fermented Soy may be considered a functional food for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Possibility of breast cancer prevention: use of soy isoflavones and fermented soy beverage produced using probiotics by Takagi A1, Kano M2, Kaga C. (PubMed)

Cranberry, the Remedy for Reducing the Risk Treatment of Nonalcoholic Fatty Liver Disease (NAFLD)

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction partly or completely the function of the liver, including liver failure.

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition caused by fat accumulated in the liver over time, in the absence of excessive alcohol use. The disease can be classified into the types of non-inflammatory fatty liver (NAFl) and inflammatory nonalcoholic steatohepatitis (NASH)(1).

Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.

According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world(2). However, due to the economic prosperity of Southeast Asian(3), the disease also was found in a large population in the cities, causing concerns of many scientists in the region(4)(6).

According to the joint assessment of the prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the US, led by the Stanford University School of Medicine, "The prevalence of NAFLD in the United States (U.S.) has risen from 18% in 1988–1991 to 31% in 2011–2012. Estimates of NAFLD prevalence for adults in Western countries are 20–30%, with much higher prevalence in adults with obesity (80–90%), diabetes (30–50%), and hyperlipidemia (90%)"(5).

The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications(8), genetic preposition(8), insulin resistance(8), high cholesterol(8) and triglycerides(8) in the blood, polycystic ovary syndrome(8), metabolic syndrome(8), obesity(8), and type 2 diabetes(8) are associated with the onset of the disease.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the prevention and treatment of liver diseases, researchers investigated cranberry effects on metabolic profiles, including that during the progression of non-alcoholic fatty liver disease (NAFLD), in a high-fat diet (HFD)-fed C57BL/6 mice.

According to the results of the experiment, the application of cranberry reduced the levels of oxidative stress in mice that were fed HFD diets with supplementation of 1 and 5% cranberry powder, compared to HFD-fed control mice.

1 week after beginning the diets to the end of the study, the body weight of mice in the cranberry-treatment groups was significantly lower, compared to mice in the HFD-fed control group.

Furthermore, during the early treatment phase, the injection of cranberry suppressed the elevation of serum triglycerides, leading to the smaller of the adipocytes in the adipose tissues in HFD-fed mice compared to the cells in HFD-fed control mice. 

More importantly, the nonalcoholic fatty liver disease (NAFLD) characteristics of the levels of lipid-droplet formation and hepatocyte ballooning in the liver were drastically decreased in cranberry-supplemented-HFD-fed mice relative to the levels in HFD-fed control mice.

Based on the findings, researchers said, " Cranberry ameliorates HFD-induced metabolic disturbances, particularly during the early treatment stage, and exhibits considerable potential for preventing the progression of NAFLD.".

Taken altogether, cranberry may be considered a functional food for the treatment of  NAFLD, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry Attenuates Progression of Non-alcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice by Shimizu K1, Ono M2, Imoto A1, Nagayama H1, Tetsumura N1, Terada T1, Tomita K2, Nishinaka T. (PubMed)
(2) Non-alcoholic Fatty Liver Disease (NAFLD)Treatment in Phytochemicals Perspective by Kyle J. Norton

Wednesday, 19 February 2020

Cruciferous Vegetables Inhibit the Onset of Glioblastoma, in Vitro

By Kyle J. Norton

Glioblastoma or glioblastoma (also called GBM) caused mostly by the abnormal astrocytic cells and dead cells (necrosis) is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.

In other words, primary glioblastoma may arise as a Grade IV tumor with no evidence.

Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.

Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.

Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.

In the US, the median age of glioblastoma diagnosed is 64 years and the incidence of the disease onset is 1.6 times higher in males compared to females.

Furthermore, the condition is 2 times higher in Caucasians compared to Africans and Afro-Americans.

GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.

According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.

If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.

The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.

On finding a potential plant that process neuro-protective researchers compared the effects of
Sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables on glioblastoma.

According to the differentiation, 
* SFN can rapidly cross the BBB and accumulate in the CNS after i.p. administration [76,77] to exert its anti-cancer activity.

* Furthermore, the application of SFN induces apoptosis and inhibits both growth and invasion of GBM cells.

SFN can overcome the chemoresistance of tumor cells.

More precisely, the effects of SFN inhibited the profession by focusing on pro-apoptotic, anti-invasion, anti-proliferative, and anti-chemo/radioresistance activities.


Taken altogether, cruciferous vegetables consisting of SFN may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment by Sita G1, Hrelia P2, Graziosi A3, Morroni F. (PubMed)