Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 30 January 2020

Lycopene Protects the Blood Vessels Against Vascular Complications in Type 2 Diabetics

By Kyle J. Norton

Vascular tissues are tissues with a lot of blood vessels, formed part of the circulatory system that carries blood to nourish the body tissues and organs including veins, arteries, and capillaries in the human body.

Vascular diseases are a group of diseases associated with an abnormal condition of the blood vessels (arteries and veins). In other words, vascular diseases are diseases that affect your circulatory system, such as peripheral artery disease.

Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Most cases of diabetes are either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

The vascular complications of diabetes can be either microvascular that induce

* Diabetic retinopathy, is a diabetic complication caused by damage to the blood vessels of the retina.

* Diabetic nephropathy is the diabetic complication that damages the kidneys.

* Diabetic neuropathy is the diabetic complication that damages nerves in the legs and feet.

Macrovascular diseases that include

* Diabetic coronary artery disease is is the most common type of heart disease associated with the hardening and narrowing arteries that supply blood to the heart muscle.

* Diabetic peripheral disease is a type of heart disease caused by narrowed arteries that reduce blood flow to your limbs.

* Diabetic cerebral vascular disease is a condition that affects the blood vessels of the brain and cerebral circulation.

Most cases of diabetes are the results of longer-term hyperglycemia caused by an unhealthy healthy lifestyle such as uncontrolled diet and physical inactivity. Failure to maintain the right blood glucose over time not only induces vascular complications but also exacerbates the risk of mortality.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a potential compound for the treatment of diabetes complications, researchers examined the effect of lycopene on vascular complications associated with endothelial progenitor cells (EPCs).

Based on the number and the function of EPCs related to the advanced glycation end products (AGEs) generated in DM patients, researchers found that
* Lycopene injection exerted its natural antioxidant activity that protects EPCs under the microenvironment of AGEs from damage.

* At the concentration of 10μg/mL, Lyc improves cell proliferation and has low cytotoxicity in the presence of AGEs.

* Lycopene also protects the vascular cells against the S phase of the cell cycle arrest, apoptosis rate by decreasing autophagic reaction between ROS and mitochondrial membrane potential (MMP) in the promotion of EPC survival associated with the activation of autophagy inhibitors,
3-Methyladenine (3-MA).

The results strongly suggested that Lyc promotes EPCs survival and protect EPCs from apoptosis and oxidative autophagy induced by AGEs against the vascular complications in diabetes subjects.

Dr. Zeng YC, the lead scientist wrote in the final report, "This study provides new insights into Lyc protective mechanism of AGEs-induced oxidative autophagy in EPCs from DM patients and offers a new therapy for DM vascular complications".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention of vascular complications in type 2 diabetics, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Ameliorated Oxidative Stress and Inflammation in Type 2 Diabetic Rats by Zheng Z1, Yin Y1, Lu R1, Jiang Z. (PubMed)

Lycopene Inhibited the Parameters Associated with Onset of Liver Cancer

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays an essential role that filters the blood from the digestive system but also produces bile to build strong cell membranes, produce vitamin D and steroid hormones.

Furthermore, the liver also aids digestive function to absorb nutrients from food intake, and protect the body against free radicals in the body through its antioxidant capacity.

Liver cancer is chronic a condition characterized by out of controlled growth of hepatocellular cells in the liver due to DNA alternation.

Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. According to the statistic, in the US, approximately, 42,030 new cases of liver cancer will be diagnosed in 2019, including 29,480 in men and 12,550 in women.

Sadly, liver cancer also will cause the death of approximately 31,780 people, including 21,600 men and 10,180 women in 2019. Believe it or not, liver cancer death rates have increased by over 2% per year since 2007

Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

The grade of liver cancer is depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancers indicate otherwise.

Out of many risks associated with the onset of liver cancer, some researchers that long-term excessive alcohol drinking may be the culprit which causes the rise of liver cancer in the US.

Linda Carroll wrote on the NBC news." Severe alcohol-related liver disease is on the rise, a new study suggests. Experts say the increase may be due to heavy binge drinking, especially in young adults.

And, "...while there has been little change in the rate of people developing alcoholic fatty liver disease, there appears to be an increase in those who are at greater risk of cirrhosis, liver cancer, and death, according to the study published in JAMA"

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound for the prevention of liver cancer, researchers examined the effects of lycopene extracted from tomatoes (LycT) on N-Nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis.

In a study of female BALB/c mice randomly divided into four groups, the Control, NDEA (200 mg NDEA/kg b.w. given i.p.), LycT (5 mg/kg b.w. given orally on alternate days) and LycT + NDEA group, researchers found that

* Lycopene treament inhibited the uncontrolled proliferation in the liver of NDEA associated with the high expression of cell-proliferation (P ≤ 0.001) in NDEA mice observed by the increased expression of genes (PCNA, Cyclin D1, and p21) associated with tumorigenesis compared to control.

* Furthermore, elevated expression of parameters associated with cancer expression in NDEA mice were also inhibited by the injection of lycopene extract compared to control.

* The aforementioned parameters correlated to the alterations in hepatic ultrastructure in the NDEA group were also inhibited by the lycopene extract.

* Moreover, according to the hepatic electron micrographs, LycT + NDEA group showed also increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma (HCC), compared to undifferentiated HCC observed in the NDEA treated group.

Based on the findings, researchers said, "This study demonstrates that dietary supplementation with LycT has a multidimensional role in preventing HCC development".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention of liver cancer pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinomawith Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes by Xia H#1, Liu C#1, Li CC#1, Fu M2, Takahashi S2, Hu KQ1, Aizawa K1,2, Hiroyuki S2, Wu G3, Zhao L3, Wang XD. (PubMed)
(2) Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma by Gupta P1, Bhatia N1, Bansal MP1, Koul A. (PubMed)
(3) Severe alcohol-related liver disease on the rise, study finds by Linda Carroll (NBC News)

Devil's claw (Harpagophytum procumbens), the Anti-Inflammatory Remedy

By Kyle J. Norton

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Diseases associated with low-grade inflammation include diabetes and cardiovascular.

Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.

On finding a natural ingredient for the prevention and treatment of liver diseases, scientists investigated the prepared an extract of Euphrasia officinalis, a traditional folk medicine, to synthesize gold nanoparticles (EO-AuNPs) anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.

Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa.

The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.

According to tested analysis, the successful synthesis of AuNPs by E. officinalis showed significant anti-inflammatory activities detected by a model of LPS-induced upregulation of inflammatory mediators and cytokines.

More precisely, AuNPs by E. officinalis inhibited the levels of nitric oxide (NO), nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), IL-1β, and IL-6 in RAW 264.7 cells.

Furthermore, EO-AuNPs exhibited little cytotoxicity in RAW 264.7 cells at 100 µg/mL concentration after 24 hours.

Pretreatment with EO-AuNPs also significantly reduced the phosphorylation and degradation of inhibitor kappa B-alpha and inhibited the nuclear translocation of NF-κB p65 involved the production of pro-inflammatory cytokines.

Additionally, EO-AuNPs suppressed LPS-stimulated inflammation by blocking the activation of JAK/STAT pathway associated with cytokines and growth factors.

Based on the results, researchers suggest, "The synthesized EO-AuNPs showed anti-inflammatory activity in LPS-induced RAW 264.7 cells, suggesting they may be potential candidates for treating inflammatory-mediated diseases".

Taken altogether, Dandelion may be considered an anti-inflammatory remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages by Liu Y1, Kim S2, Kim YJ1,2, Perumalsamy H2, Lee S3, Hwang E4, Yi TH. (PubMed)

Herbal Cleaver(Galium aparine), inhibits the Melanoma Cell Metastasis in Vitro

By Kyle J. Norton

Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.

Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.

The most common sites of melanoma metastasis are the lung and breast.

The most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.

The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.

* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.

* Lentigo malignant melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.

* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.

Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.

Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.

On finding a potential compound for the treatment of skin diseases, researchers investigated the Gallic acid (GA) found in herbal Cleaver in the inhibition of the growth of human cancer cells in vitro and in vivo.

GA decreases the expression of MMPs MMPs mRNA levels in A375.S2 human melanoma cells in stimulating the cancer cell metastasis.

Furthermore, GA processed antimetastatic potential by decreasing the invasiveness of cancer cells.

Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways with function to communicate a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell to induce the inhibition of MMP-2 associated with cancer spreading in A375.S2 human melanoma cells.

Based on the findings, researchers said, " These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells".

Taken altogether, Comfrey may be considered a remedy to inhibit cancer call spreading, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras by Lo C1, Lai TY, Yang JS, Yang JH, Ma YS, Weng SW, Lin HY, Chen HY, Lin JG, Chung JG. (PubMed)

Wednesday, 29 January 2020

Common Fig or Fig (Ficus carica) Gobbles Up Triple-Negative Invasive Breast Cancer in Vitro

By Kyle J. Norton

The women's breasts are made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a women's breast is totally determined by the amount of fat.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. There are also rare cases that breast cancer starts in other areas of the breast.

At the advanced stage, after colonizing the entire breast the adance stage, malignant cancers can travel a distance away to infect other healthy cells and tissue.

The exact causes of breast cancer are unknown.

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.

Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.

In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone or genetic preposition.

More importantly, triple-negative breast cancer was found to infect women under the age of 40 and women of African or Asian ancestry in the US, compared to breast cancer in the White.

Particularly, according to the epidemiological study, younger women and in women of African ancestry are susceptible to a higher risk of basal-like triple-negative breast cancers.

Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive which can grow and spread quickly to other tissues and organs through lymph and blood.

Also compared to other breast cancers, with decreased risk after 5 years, triple-negative breast cancers have a substantial higher recurrent rate within 5 years after treatment.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding a natural compound or whole food for the treatment of cancer, researchers investigated the effects of Ficus carica leaves on triple-negative breast cancer MDA-MB-231 cells.

According to the tested differentiation, the application of Ficus carica leaves promoted the gene expressions associated with apoptosis.

Furthermore, Ficus carica leaves also demonstrated significant activity in the induction of S phase cell cycle arrest by changing the expression of cyclin-dependent kinases involved in the cancer cell cycle division.

The cell mobility associated with metastasis. in the cells was also inhibited by the application.

Most importantly, 2 chemical compounds bergapten and psoralen found in the F. Carica leaves also had similar anticancer effects as F. Carica leaf extracts.

Based on the results, researchers wrote, "F. Carica leaves might be a good source to develop drugs for suppressing cancer-cell growth and migration to treat triple-negative breast cancers".

Taken altogether, common fig or fig (Ficus carica) may be considered a remedy for the prevention and treatment of triple-negative breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells by Yu Zhang,1 Youzhong Wan,1,2 Bo Huo,1 Boyuan Li,1 Yue Jin,1 and Xin Hu. (PMC)

Broccli Processes Anti Nasopharyngeal Cancer Activity

By Kyle J. Norton

Cancers are a class of chronic and medical conditions characterized by cells growth irregularly and disorderly in the tissue of a specific organ.

Most cases of cancer start in the cell on the surface of the inner lining of organ tissue caused by the alternation of the cell DNA.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, based on the 2013–2015 data.

In 2017, about15,270 children and adolescents ages 0 to 19 were diagnosed with cancer. Cancer in the same year also causes the death 1,790 of children and adolescents Americans.
The nasopharynx is the upper part of the pharynx, connecting with the nasal cavity above the soft palate that allows a person to breathe through the nose.

Nasopharyngeal cancer is a medical condition characterized by cells growth irregularly and disorderly in the tissues of the nasopharynx.

Most cases of nasopharyngeal cancer start in the cells on the surface of the inner lining of the nasopharynx.

According to the statistics provided by the American cancer society, nasopharyngeal cancer (NPC) is quite rare in the United States). The risk of cancer is less than one case for every 100,000 people.

Epidemiologically, some patients at this stage may also experience symptoms of frequent ear infections, hearing loss and headaches.

The exact causes of nasopharyngeal cancer are unknown. Gender, family history, ethnicity, where you live, poor diet, infected by the Epstein-Barr virus are some of the prevalent factors of nasopharyngeal cancer.

On finding a potential plant that processes anti-cancer activity researchers compared the effects investigate the role of miRNAs from broccoli in human nasopharyngeal cancer (NPC).

Where microRNAs (miRNAs), a small non-coding RNA molecule found in plants, animals and some viruses have been documented as having an important role in the development of cancer.

According to the analysis of a total of 84 conserved miRNAs and 184 putative novel miRNAs in broccoli by sequencing technology, the most abundant miR156a mimic inhibited the EMT of NPC cells in vitro.

The molecular genetics 3' UTR of Junctional adhesion molecule A (JAMA) associated with cancer cell migration and tight junctions was inhibited by the miR156a mimic on the tested EMT of NPC.

Collectively, researchers said, "These miRNA profiles of broccoli provide a fundamental basis for further research. Moreover, the discovery of miR156a may have clinical implications for the treatment of patients with NPC".

Taken altogether, broccoli which consists of microRNAs may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) miR156a Mimic Represses the Epithelial-Mesenchymal Transition of Human Nasopharyngeal Cancer Cells by Targeting Junctional Adhesion Molecule A by Tian Y1, Cai L1, Tian Y2, Tu Y1, Qiu H1, Xie G1, Huang D1, Zheng R1, Zhang W. (PubMed)

Cranberry Inhibits Herpes simplex virus 1 and 2 (HSV-1, 2) Infection

By Kyle J. Norton

Herpes simplex virus 1 (HSV-1) primarily causes oral herpes, including cold sores and fever blisters around the mouth and on the face.

Herpes simplex virus-2 (HSV-2) primarily causes genital herpes and genital herpes outbreaks

Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulates the production of blood palette to the cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.

However, overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damage to the nearby healthy cells, leading to the formation of scars.

In most cases in a healthy individual, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.

Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, and diarrhea, short term joint or muscle pain, fever, headache, skin rash and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.

In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.

Most cases of infection except those of viral infection are treated by topical antibiotic cream and/or oral antibiotics.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of skin infection, researchers investigated the effects of cranberry (Vaccinium macrocarpon Ait.) extracts Oximacro(®) against Herpes simplex type 1 (HSV-1) and type 2 (HSV-2) infections.

In vitro, the novel cranberry extract Oximacro(®) and its purified A-type proanthocyanidins (PACs-A) inhibited HSV-1 and HSV-2 replication.

Furthermore, Oximacro(®) prevented the adsorption of HSV-1 and HSV-2 to target cells.

Moreover, Oximacro(®) and its PACs-A targeted the viral envelope glycoproteins gD and gB to enter cells, thus resulting in the loss of infectivity of HSV particles.

Most importantly, Oximacro(®) completely exerted continuously its anti-HSV activity even at acidic pHs (3.0 and 4.0) and in the presence of 10% human serum proteins, and conditions that mimic the physiological properties of the vagina.

Based on the findings, researchers said, "Oximacro(®) as an attractive candidate for the development of novel microbicides of natural origin for the prevention of HSV infections".

Taken altogether, cranberry may be considered immune-modulatory remedy, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Inhibition of herpes simplex type 1 and type 2 infections by Oximacro(®), a cranberry extract with a high content of A-type proanthocyanidins (PACs-A) by Terlizzi ME1, Occhipinti A2, Luganini A3, Maffei ME4, Gribaudo G. (PubMed)