Herbal Angelica, Processes Apoptotic and Anti Proliferative Function in Vitro

By Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.

In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.

In the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.

A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.

In the programmed cell death gene, such as BCL-2 induce cell death by either inducing apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.

In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of cancer, researchers examined the effects of Angelica phytochemical (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone from A. purpuraefolia on cell proliferation and apoptotic cell death.

In 4 breast (MDA-MB-231, MCF-7, HS578T, and T47D), three cervical (HeLa, SiHa, and C33A) cancer cell lines, and NIH 3T3 normal cells used for the experiment, researchers found that
* (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone treatment suppresses the growth and proliferation of cancer cells at a relatively low concentration (<10 μg/ml).

* The phytochemical also induces cancer cell apoptosis at a high concentration (>50 μg/ml).

* At the concentration of 10 μg/ml, the chemical compounds also exerted a strong cell cycle arrest in the S/G2 phase.

Furthermore, according to the Western blot analysis, the concentration higher than 50 μg/ml of (+)-4'-decanoyl-cis-khellactone increased the large percentage of apoptotic cells in a time-dependent manner.

Interestingly, while the (+)-4'-decanoyl-cis-khellactone using both extrinsic and intrinsic pathways to induce apoptosis, the but (+)-3'-decanoyl-cis-khellactone uses only an intrinsic pathway for the same results.

In other words, the (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone also inhibited the in vitro proliferation of six other human breast and cervical cancer cell lines with different pathways.

Based on the evidence, researchers said, "Our data strongly suggest that (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone act as an anti-cancer supplement particularly against breast and cervical cancers by inducing cell cycle arrest in the S/G2 phase and caspase-dependent apoptosis at relatively low and high concentrations, respectively".

Taken altogether, Herbal Angelica processes anti-proliferative activity against cancer, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effect and mechanism on antiproliferation of khellactone derivatives from herbal suitable for medical or food uses by Jung S1, Li C, Lee S, Ohk J, Kim SK, Lee MS, Moon HI. (PubMed)

Herbal Coltsfoot(Tussilago farfara) Processes Anti Cancer and Bacterial Infections Activity

By Kyle J. Norton

Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.

At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of cancer.

Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.

According to the statistic provided by the American Cancer Society, in the US 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results of cancer.

Furthermore, in the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

Bacterial infections are a class of diseases caused by harmful bacteria.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.

On finding a potential compound for the treatment of malignant tumors and diseases associated with bacterial infections, scientists examined the Sesquiterpenoids from the flower bud extract of Tussilago farfara as a reducing agent for eco-friendly synthesis of silver and gold nanoparticles for the treatment of cancer and infectious diseases.

Where the silver and gold nanoparticles had a characteristic surface plasmon resonance at 416 nm and 538 nm, respectively.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

According to the tested analysis, the silver nanoparticles showed a significantly better activity (two- to four-fold enhancement) on both Gram-positive and Gram-negative bacteria, compared to the extract.

The gold nanoparticles exerted a strong anti-cancer cytotoxic activity compared to those of silver nanoparticles.

Furthermore, both gold and silver nanoparticles. demonstrated the highest cytotoxicity on human pancreas ductal adenocarcinoma cells.

Based on the results, researchers said, "Therefore, both nanoparticles synthesized with the sesquiterpenoids from T. farfara flower bud extract can be applied as drug delivery vehicles of anticancer or antibacterial agents for future nanomedicine applications".

Taken altogether, coltsfoot may be considered a remedy for the treatment of bacterial infections and cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities by Lee YJ1, Song K2, Cha SH3, Cho S4, Kim YS5, Park Y. (PubMed)

Broccoli Enhances Xenobiotic Metabolism Against the Risk of Cancer

By Kyle J. Norton

Xenobiotic metabolism is an action that protects the host against chemicals that affect normal metabolism.

Other common metabolisms may include

* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, also has been found to protect the gut mucosal barrier in preserving the ability to absorb nutrients.

* Drug metabolism is the process to alter chemical of a drug that may cause harm to the body

The gut microbiota plays a critical role in regulating the systemic metabolism of the host including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile by interacting with other organs such as intestine, liver, brain, and other organs through the host-microbiota and co-metabolism structure to form an ametabolic axis.

More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of the dietary nutrients of the digestive system

* Gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.

* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

Imbalanced of the ratio of gut microbiota may have a negative impact on human health and diseases.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects sulforaphane (SF), the isothiocyanate derived from 4-methyl-sulphinyl butyl glucosinolate in broccoli induce-xenobiotic metabolizing.

The study included 16 subjects randomized, into 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.

According to the results of the trial, consumption of high glucosinolate broccoli showed a strong effect in the improvement of several xenobiotics metabolizing genes, including thioredoxin reductase, Aldo-keto reductases, and glutamate-cysteine ligase modifier subunit.

Furthermore, the affected genes also have been found to be improved after exposure to SF, in cell and animal models.

Compared to phytochemical sulforaphane (SF) and sulforaphane (SF), only 1 such gene was affected in the consumption of standard broccoli.

Taken altogether, the consequences of these results suggest that the broccoli process the potential anticarcinogenic activity by upregulating the gene associated with xenobiotic metabolism, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Consuming broccoli does not induce genes associated with xenobioticmetabolism and cell cycle control in human gastric mucosa by Gasper AV1, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barrett DA, Mithen RF. (PubMed)

Dandelion (Taraxacum officinale), the Best Antioxidant Functional Herbal Medicine

By Kyle J. Norton

Antioxidants are stable atoms that inhibit oxidation caused by free radicals.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.

Believe it or not, free radicals also play a critical role in maintaining a certain body function. The Journal of Physiology showed that free radicals act as signal substances that cause the heart to beat with the correct force.

In healthy individuals, antioxidant enzymes produced by the liver are good enough to balance the free radical produced by the cell metabolism and external sources such as the air we breathe and the food we eat.

However, in people with a weakened immune system such as infants, children and the elderly, dietary sources from supplements, fruits and vegetables may be needed.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world.

The herbal medicine has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined in vitro and in vivo the antioxidant effects of 70% ethanol-water (v/v) leaf and root extracts of T. officinale (TOL and TOR, respectively).

The study included organ homogenate samples from Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats, treated by leaf extracts of TOL (500 mg/kg/day) and TOR (500 mg/kg/day) for 21 days.

Based on the results from the experiment, the antioxidant contents of ) polyphenol (4.35 ± 0.15 compared to 1.14 ± 0.01) and flavonoid (23.17 ± 0.14 compared to 3 ± 0.05) of TOL are significantly higher compared to TOR.

TOL exerted a significantly higher free radical scavenging activity (EC50 0.37 compared to 1.34 mg/mL) and total antioxidant capacities (82.56% compared to 61.54% ABTS, and 156 ± 5.28 compared to 40 ± 0.31 FRAP) compared to TOR.

Furthermore, both extracts inhibited the oxidative stress marker MDA levels and increased the total antioxidant capacity (TAC) without inducing toxicity with LD50 > 5000 mg/kg).

Collectively, T. officinale leaf extract possesses significant anti-oxidant effects that conferred significant in vivo antioxidant protection against free radical-mediated oxidative stress in L-NAME-induced hypertensive rats.

Taken altogether, dandelion may be considered a remedy for enhancing the antioxidant capacity against oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats by Aremu OO1, Oyedeji AO2, Oyedeji OO3, Nkeh-Chungag BN4, Rusike CRS, (PubMed)

Turmeric Protects the Heart Cells Against Cardio-Oxidative Stress

By Kyle J. Norton

Oxidative stress occurs when the levels of free radical compared to the antioxidant enzymes in the body is imbalanced.

Oxidative stress is either associated with the overexpression of free radicals or reduced levels of antioxidants or both.

Free radicals can be everywhere in the environment such as the air we breathe, the foods we eat. They can also be produced by cell metabolism in the body.

Overexpression of free radicals is harmful to the body. However, in a moderate amount, free radicals are necessary for our body to function, including NO for muscle relaxation.

Epidemiologically, oxidative stress has been found to induce lipid and protein oxidation and cell DNA damage, a leading cause of various chronic diseases such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke.

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels by providing the body with oxygen and nutrients and removal of metabolic wastes.

In the heart, cardio-oxidative stress causes heart muscle damage, leading to dilated cardiomyopathy and heart failure.

Dr. Dhalla NS, the lead scientist, in the examination of the risk of oxidative stress in cardiovascular disease, wrote, "Oxidative stress in cardiac and vascular myocytes describes the injury caused to cells resulting from the increased formation of ROS and/or decreased antioxidant reserve. The increase in the generation of ROS seems to be due to the impaired mitochondrial reduction of molecular oxygen, secretion of ROS by white blood cells, endothelial dysfunction, auto-oxidation of catecholamines, as well as exposure to radiation or air pollution"

And "On the other hand, depression in the antioxidant reserve, which serves as a defense mechanism in cardiac and vascular myocytes, appears to be due to the exhaustion and/or changes in gene expression".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of heart disease, researchers examined The mechanism of curcumin on cardiotoxicity-induced production of excess intracellular ROS.

In vivo myocardial injury model in mice and primary cardiomyocytes in vitro, the bioactive compound showed significant activity against the Dox-induced injury to the myocardium by elevating the protein expression of 14-3-3γ in total protein and Bcl-2 expression on mitochondria associated with oxidative stress.

Furthermore, the anti cardio oxidative stress induced by Dox was also inhibited by the injection curcumin by activating Bad (S112) phosphorylation against cell death and, reducing the heart rate, ST-segment, low-density lipoprotein (LDH) and creatine kinase (CK) activities found in the serum.

In other words, curcumin decreased cardiotoxicity by protecting the heart muscle cells' integrity through many mechanisms, including proteins associated with oxidative stress in the induction of apoptosis.

Based on the findings, researchers said, "Cur protected the myocardium against Dox-induced injury via upregulating 14-3-3γ expression, thereby promoting the translocation of Bcl-2 to mitochondria, suppressing oxidative stress, and improving mitochondrial function".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of heart diseases associated with cardio-oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ by He H 1, Luo Y, Qiao Y, Zhang Z, Yin D, Yao J, You J, He M. (PubMed)
(2) Assessment of herb-drug synergy to combat doxorubicin-induced cardiotoxicity by Jain A1, Rani V. (PubMed)
(3) Role of oxidative stress in cardiovascular diseases by Dhalla NS1, Temsah RM, Netticadan T. (PubMed)

Herbal Angelica in the Prevention and Treatment of Ulcerative Colitis

By Kyle J. Norton

Colitis is a condition of inflammation of the large intestine, including the colon, caecum, and rectum.

There is a number of causes of the disease, including infection, inflammatory bowel disease, and allergic reactions.

Ulcerative colitis is a condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.

More precisely, ulcerative colitis is a chronic disease that causes inflammation and ulcers within the inner lining of your large intestine. Most cases of ulcerative colitis start in the rectum and spread to the colon.

Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus, persistently abdominal pain, rectal pain, and bleeding, particularly the inability to defecate despite the urgency.

Some patients with UC may also have symptoms of weight loss, fatigue fever.

According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.

Depending on the location, most common types of UC can be classified into * Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, fever.
* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.

* Proctosigmoiditis is an Inflammation involved in the rectum and sigmoid colon (lower end of the colon).

The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.

The most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention of colitis, researchers examined the decursin and decursinol angelate-rich Angelica gigas Nakai (AGNE) on dextran sulfate sodium (DSS)-induced murine ulcerative colitis (UC) in a mouse model.

In mice with DSS-induced UC, treatment with the AGNE at 10, 20, and 40 mg/kg exerted strong colonic protection and activity by alleviating decreased disease activity index scores, and reduced colon shortening and weight loss.

Levels of pro-inflammatory cytokines were also decreased in serum and colon tissue with the administration of AGNE.  

Furthermore, AGNE also improved the colon movement by increasing the production of PGE2 in colon tissue and suppressed the increased expression of COX-2 and HIF-1α in the increased intestinal mucosa of UC mouse.

Finally, the histological damage of the colon was also alleviated by AGNE treatment.

Collectively, researchers said, "The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC".

Taken altogether, herbal Angelica may be considered a  remedy dor the treatment of UC, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis by Oh SR1, Ok S1, Jung TS1, Jeon SO1, Park JM1, Jung JW2, Ryu DS. (PubMed)

Broccoli In the Prevention of Colitis

By Kyle J. Norton

Colitis is a medical condition of inflammation of the large intestine, including the colon, caecum, and rectum.

Types of colitis according to the Catholic University of the Sacred Heart, are including
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.

There is no exact cause of colitis. Certain risk factors such as colon infection, inflammatory bowel disease (Crohn's disease, ulcerative colitis), ischemic colitis, allergic reactions, and microscopic colitis have been found to increase the risk of the onset of the condition.

The most common symptoms of colitis are totally depending on the types, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

The most common risk factors associated with the onset of colitis are Medical conditions such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation aging, genders, smoking, depression, and psychosocial stress and family history.

Other risk factors may also contribute to the incidence of colitis, according to the study by Service d'Epidémiologie et de Santé Publique, in a multivariate model are familial history of inflammatory bowel disease (odds ratio (OR) 4.3 (95% confidence interval 2.3-8)), breastfeeding (OR 2.1 (1.3-3.4)), bacille Calmette-Guerin vaccination (OR 3.6 (1.1-11.9)), and history of eczema (OR 2.1 (1-4.5)), disease during pregnancy (OR 8.9 (1.5-52)), and bedroom sharing (OR 7.1 (1.9-27.4)).

Conventionally, besides treating colitis with antibiotics, certain medications also are prescribed to improve the symptoms and quality of life of the patients, including anti-diarrheal medications.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that process anti-colitis activity researchers compared the effects of broccoli-derived nanoparticle (BDN) and SFN on three mouse colitis models.

According to the data collected from the experiment, orally given nanoparticles isolated from broccoli extracts protected mice against colitis by-mediating the activation of 5'-adenylic acid-activated protein kinase (AMPK) associated with cellular energy homeostasis.

In the immune analysis, BDN prevented the dendritic cells (DCs) to act as messengers between the innate and the adaptive immune systems in dextran sulfate sodium (DSS)-induced colitis in C57BL/6 (B6) mice by targeting dendritic cells (DCs) activation and inducing DC tolerance.

Compared to BND, DCs pre-pulsed with SFN also prevented DSS-induced colitis in B6 mice,, similar to those of BND.

Taken altogether, broccoli derived nanoparticle (BDN) or SFN isolated from broccoli may be considered a functional food for the prevention and treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase by Deng Z1, Rong Y1, Teng Y1, Mu J1, Zhuang X1, Tseng M2, Samykutty A1, Zhang L1, Yan J1, Miller D1, Suttles J1, Zhang HG. (PubMed)
(2) Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study by Baron S1, Turck D, Leplat C, Merle V, Gower-Rousseau C, Marti R, Yzet T, Lerebours E, Dupas JL, Debeugny S, Salomez JL, Cortot A, Colombel JF. (PubMed)