Turmeric Processes Anti-Metastatic Activity

By Kyle J. Norton

Cancer is a class of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.

Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

Metastasis is the process to induce the development of secondary malignant growths at a distance from primary cancer.

Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.

According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the prevention of metastasis in cancer, researchers examined the effects of Furanodiene, a bioactive compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin) on tumor metastatic activities.

According to the tested differentiation, low concentrations (5-25μM) of furanodiene inhibited adhesion, migration, and invasion of breast cancer cells, without inducing cytotoxicity, apoptosis and cell cycle arrest.

Furthermore, furanodiene also regulated the parameters such as the integrin αV expression, β-catenin expression, associated with the cell survival, migration, proliferation, differentiation, angiogenesis, and remodeling of the extracellular matrix in the modulation of the tumor metastasis process.

In MDA-MB-231 cells, furanodiene modulated the matrix metalloproteinase 9 (MMP-9) involved in tumor metastasis and cancer markers.

Based on the results Dr. Zhong Z, the lead scientist said, "furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer".

Taken altogether, turmeric processed a high amount of bioactive compound furanodiene may be considered supplements for the prevention of tumor metastasis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro by Zhong Z1, Tan W1, Chen X2, Wang Y. (PubMed)

Chinese Sauerkraut, the Anti Hyperuricemia Functional Food

By Kyle J. Norton

Hyperuricemia is a condition of an excess of uric acid in the blood caused by reduced renal function.

The most common causes of hyperuricemia are genetics, insulin resistance, hypertension, hypothyroidism, obesity, diet, medications such as diuretics, and consumption of excess alcoholic beverages.

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in the blood, inducing joint inflammation.

The causes of gout are the result of high levels of uric acid in the body that can lead to the forming of crystals causes of inflammation due to your body can not get rid of uric acid or have made too much uric acid.

Reduced intake of meats and seafood and foods containing higher levels of uric acid, such as alcoholic beverages, especially beer, and drinks sweetened with fruit sugar (fructose) in patients with gout may be necessary.

According to the New York University School of Medicine/Langone Medical Center, the prevalence of gout and hyperuricemia has increased dramatically during the last several decades, to the point that gout is the most common inflammatory arthritis in the United States, affecting approximately 8 million Americans and contributing to great numbers of hypertension, chronic kidney disease, and cardiovascular disease.

The most common medication for the treatment of gout is Non-steroidal anti-inflammatory drugs (NSAIDs) by reducing pain and inflammation during an attack.

Chinese sauerkraut is a traditional Chinese pickled Chinese cabbage.

Depending on the regions, in Northern China,  Napa cabbages were traditional vegetables of choice to make Chinese sauerkraut.

In Southern China,  thick stalk varieties of Chinese mustard are preferred.

On finding the potential compound for the prevention and treatment of gout, researchers led by the Dalian Medical University investigated fifty-five lactic acid bacteria isolated from Chinese sauerkraut which have the ability to degrade inosine and guanosine, the two key intermediates in purine metabolism.

According to tested analysis, the strains DM9218 showed the best probiotic potential compared with other strains despite its poor bile resistance compared to strain DM9218-A which showed better resistance to 0.3% bile salt.

DM9218 has the highest probiotic activity similarity (99%) to those of Lactobacillus Plantarum WCFS1.

Furthermore, the strain DM9218-A showed a significant effect to inhibit the level of serum uric acid in the hyperuricemic rat.

Moreover, DM9218-A in The preventive treatment caused a greater reduction in serum uric acid concentration in hyperuricemic rats than the later treatment.

Based on the findings, researchers said, "DM9218-A may be a promising candidate as an adjunctive treatment in patients with hyperuricemia during the onset period of the disease. DM9218-A also has potential as a probiotic in the prevention of hyperuricemia in the normal population".

Taken altogether, Chinese sauerkraut processed a high amount of DM9218-A may be used as probiotics for the prevention and treatment of gout, pending to large sample size and multicenter study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Screening and characterization of purine nucleoside degrading lactic acid bacteria isolated from Chinese sauerkraut and evaluation of the serum uric acid-lowering effect in hyperuricemic rats by Li M1, Yang D1, Mei L2, Yuan L3, Xie A1, Yuan J. (PubMed)
(2) The Clinical trials and Studies of musculoskeletal disorders(MSDs) - Gout: The Causes by Kyle J. Norton

Broccoli or Broccoli sprouts Do Not Cause Thyroidial Toxicity Induced-Thyroid Dysfunction or Thyroid Autoimmune Disease

By Kyle J. Norton

Thyroid disease is a medical condition that causes a malfunction of the thyroid.

Hyperthyroidism is a condition in which the thyroid gland is overactive and produces too much thyroid hormones. 

The most common symptoms of hyperthyroidism are excessive sweating, heat intolerance, increased bowel movements, shaking, nervousness, agitation, anxiety, rapid heart rate, palpitations, irregular heart rate, weight loss, fatigue, weakness...

Hypothyroidism is a condition in which the thyroid gland is underactive and produces very little thyroid hormones.

Symptoms of hypothyroidism are depended on the severe stage of the disease. as it progresses slowly over years such as weight gain and fatigue, vitiligo and alopecia areata, chronic constipation, urticaria and puffiness of hands and feet, yellow ivory skin, coarse rough dry skin, alopecia periorbital edema, amenorrhea, dyspareunia, PCO, PMS and breast tenderness, menstrual irregularities and infertility,...

Thyroid toxicity that affects the function of the thyroid gland not only causes thyroid dysfunction but also induce thyroid autoimmune disease.

According to Dr. Catherine Sutcliffe, the lead scientist in the study of "Endocrine Disruption of Thyroid Function" wrote, "The common factor in the direct thyroid toxicity mechanisms so far outlined is the reduction of thyroid hormone production and secretion. The reduction of thyroid hormones (T4 or T3) results in compensatory increased secretion of TSH due to the concomitant diminution of feedback control (see Figure 11.3)".

And, "It is important to note that increased TSH stimulation of the thyroid produces the same histopathological effects irrespective of the mechanism by which TSH is increased including thyroid growth evidenced by increased size and weight".

There are a number of causes of thyroid toxicity including short and long term intake of some medications (sunitinib has been found to cause thrombocytopenia and hypoglycemia in 62 patients) and xenobiotics.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding the thyroidal toxicity.of sulforaphane, a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout, researchers examined the effect of the phytochemical sulforaphane effect on Nrf2 (NFE2-related factor 2) that leads to thyroid dysfunction or thyroid autoimmune disease.

According to the results of the biochemical measures of thyroid function and thyroid autoimmunity in 45 female participants in a randomized clinical trial at baseline and after 84 days of beverage administration, researchers found that

* Broccoli sprout-derived products shows promising activity for the prevention of oxidative stress-related diseases.

* Sulforaphane did not affect the serum levels of thyroid-stimulating hormone, free thyroxine, and thyroglobulin.

* More importantly, sulforaphane does not affect thyroid autoimmunity status.

Based on the findings, researchers said, "These results provide evidence in favor of the safety of chemoprevention strategies that target the activation of Nrf2 to protect against environmental exposures and other oxidative stress-related pathologies".

Taken altogether, Broccoli sprouts may is safe for the prevention and treatment of oxidative stress-related diseases without causing thyroidal toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial by Chartoumpekis DV1, Ziros PG2, Chen JG3, Groopman JD4, Kensler TW1, Sykiotis GP. (PubMed)
(2) Thyroid Toxicity (Science Direct)

Collard Greens Process Thrombolytic Activity

By Kyle J. Norton

Platelet aggregation is a condition characterized by platelets clumping together in the blood. The process also is necessary for the recovery of vascular injury. However, overexpression of platelet counts in the blood is problematic to human health.

In other words, the production of blood platelets is to protect tissue injury against infection.
Furthermore, platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including

* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds and bleeding in the mouth and gums.

* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.

* Disorder of platelet secretion is a condition that causes the slows down normal platelet adhesion, aggregation, and repair of the blood vessel.

* Disorder of platelets procoagulant activity, also know as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.

Conventionally, certain medications with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.

Dr. Wolberg AS in the examination of fibrinolysis in the changes on the local concentrations of pro- and anti-coagulants and cellular activities may affect the clot-forming wrote, "patterns of abnormal thrombin generation produce clots with altered fibrin structure and that these changes are associated with an increased risk of bleeding or thrombosis".

These results strongly outline the importance of fibrin in the formation of a blood clot in the presence of thrombin that converts fibrinogen to fibrin.

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

On finding a potential plant that process thrombolytic activity researchers compared the effects of
the clot lysis effect of the crude extracts and fractions of five Bangladeshi plant viz., Trema Orientalis L., Bacopa monnieri L., Capsicum frutescens L., Brassica oleracea L. and Urena sinuata L.
The study was conducted in vitro thrombolytic model with streptokinase as a positive control and water as a negative control.

Family of Brassica oleracea showed a range of clot lysis activity of 30.24 ± 0.95% compared to 46.44 ± 2.44% in T. Orientalis, 48.39 ± 10.12% in B. monnieri, 36.87 ± .27% in C. frutescens, and 47.89 ± 6.83% in U. sinuata, compared with positive control on standard streptokinase (80.77 ± 1.12%) and negative control on sterile distilled water (5.69 ± 3.09%).

Low-value clot lysis activity of the Family of Brassica oleracea was found associated with a lack of bio-active components and/or insufficient quantities in the extract.

According to the clot lysis results, chloroform soluble phytochemicals from these plants were found to contribute to the activity of thrombolysis.

Therefore, chloroform soluble phytochemicals isolated from these plants including the Family of Brassica oleracea may be incorporated as a thrombolytic agent for the improvement of the patients suffering from atherothrombotic diseases.

Taken altogether, collard green consists of chloroform soluble phytochemicals that may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis by Emran TB1,2, Rahman MA3, Uddin MM4, Rahman MM5, Uddin MZ6, Dash R7, Layzu C. (PubMed)

Herbal Ashwagandha, the Anti Male Infertility Functional Remedy

By Kyle J. Norton

Fertility is a natural process to ensure the survival of human species. Through natural selection, we produce many offsprings when the reproductive system works at its peak in a suitable environment.

In other words, female fertility is the ability of women to conceive a biological child before menopause compared to male fertility which generally relies on the quantity and quality of the sperms.

But regardless of all factors, most women are capable of conceiving during their menstrual cycle before reaching the stage of menopause.

Infertility is a condition characterized by the inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to term.

The condition affects over 5 millions couples alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seek help from a professional specialist.

Male infertility is a medical condition associated with the male's inability to cause pregnancy in a fertile female. 

Male infertility accounts for 40–50% of all cases of infertility, affecting over 7% of all men. 

Most cases of male infertility are the results of deficiencies in the semen, and semen quality that lead to reduced function of male fecundity.

The exact causes of male infertility are not identified. However, abnormal sperm production or function due to genetic defects, and medical conditions such as diabetes, or infectious diseases such as chlamydia, gonorrhea, mumps are some of the prevalent factors that are involved in the increased risk of male infertility.

Believe it or not, stress caused by a number of health problems, including heart disease, asthma, obesity, and depression may lead to reduce sperm and semen quality in male fertility.

Dr. Nargund VH said, "Psychological stress can be defined as any uncomfortable 'emotional experience' accompanied by predictable biochemical, physiological and behavioral changes or responses. Many clinical studies looking at the effects of psychological stress on male fertility have shown that stress is associated with reduced paternity and abnormal semen parameters".

And, "psychological stress could severely affect spermatogenesis, mainly as a result of varying testosterone secretion. The hypothalamic-pituitary-adrenal axis has a direct inhibitory action on the hypothalamic-pituitary-gonadal (HPG) axis and Leydig cells in the testes. The newly discovered hormone, gonadotropin-inhibitory hormone (GnIH), also has an inhibitory effect on the HPG axis. Inhibition of the HPG axis results in a fall in testosterone levels, which causes changes in Sertoli cells and the blood-testis barrier, leading to the arrest of spermatogenesis".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potential compound for the improvement of male fertility, researchers examined the efficacy and safety of W. somnifera treatment in infertile men.

The evidence-based systematic review and meta-analysis were conducted by searching the database of medical literature PubMed/MEDLINE, EMBASE, Scopus, the Cochrane Library, and DHARA. Grey literature was assessed from the WHO International Clinical Trials Registry Platform (http://apps.who.int/trialsearch/) and the US National Institutes of Health (https://clinicaltrials.gov/).

According to the the 4 clinical trials (comprising 5 publications: observational, n = 4; randomized controlled trial [RCT], n = 1) only one RCT were included in the analysis, W. somnifera treatment significantly improved semen parameters including semen volume: mean difference [MD], 0.28  ml; sperm concentration: MD, 13.57 million/ml; sperm motility: MD, 8.50%

Furthermore, W. somnifera administration also improve the fertility rate in normozoospermic men by 14%

Moreover, according to the results of meta-analysis, W. somnifera treatment also exerted a significant improvement in serum hormonal profile, oxidative biomarkers and antioxidant vitamins in seminal plasma.

No adverse effects were reported during the study.

In other words, W. somnifera enhances all parameters associated with sperm integrity and viability in the promotion of conception without inducing any side effects.

Based on the findings, researchers after taking other factors into account wrote, "Due to a small number of eligible studies, the available data, though promising, are too limited to provide novel and sufficiently robust evidence of the benefits of W. somnifera in male infertility. Additional RCTs of high quality with a larger sample size are warranted to further strength clinical use of W. somnifera in treating male factor infertility".

Taken altogether, Ashwagandha may be considered a remedy for the treatment of male infertility, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of Withania somnifera (Ashwagandha) in the management of male infertility by Sengupta P1, Agarwal A2, Pogrebetskaya M3, Roychoudhury S4, Durairajanayagam D5, Henkel R. (PubMed)
(2) Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis by Durg S1, Shivaram SB2, Bavage S. (PubMed)
(3) Effects of psychological stress on male fertility by Nargund VH. (PubMed)

Lycopene Inhibits Asthma-COPD Overlap Syndrome (ACOS)

By Kyle J. Norton

Lung protection is an action in which substances, including herbal remedies, are used to protect the lung against injury or damage.

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove the carbon dioxide and other waste gases from the body.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.

In 2017, 28,600 Canadians were diagnosed with lung cancer, represented 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, smoking are some of the most prevalent factors associated with the onset of the disease.

Most common lung diseases in North America including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.

Asthma is a medical and chronic condition characterized by the long-term inflammation of the airways of the lungs.

Most common symptoms of asthma are episodes of wheezing, coughing, chest tightness, and shortness of breath, and reversible airflow obstruction and bronchospasm.

Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.

Asthma not only interferes with daily activities and also can lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episode and severity of the attacks.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.

Chronic obstructive pulmonary disease (COPD) is a type of lung disease associated with long-term breathing problems and poor airflow, leading to shortness of breath and cough with sputum production.

COPD is a progressive disease and the third leading cause of death in the United State. Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of asthma researchers examined the effects of ascorbic acid (AA), carotenoids (lutein, zeaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene), retinol and α-tocopherol levels in patients with allergic asthma compared to healthy elderly in Japanese.

Based on the tested analysis, comapred to other phytochemicals, plasma AA level was significantly lower in of allergic asthma subjects than that of healthy elderly people. 

Levels of plasma lycopene and total carotenoid levels and levels of antioxidant enzymes such as GSH content produced the host was significantly lower in COPD subjects comapred to those of healthy elderly people.

However, levels of plasma lycopene and total carotenoid levels showed no effects in the redox markers such as GSSG, GSH/GSSG ratio associated with the oxidative stress in the lung tissues.

In other words, there is no difference between the redox markers such as GSSG, GSH/GSSG ratio in both groups.

Furthermore, lycopene and total carotenoid levels did not lower the marker of the levels of urinary 8-OHdG detected between ACOS and BA subjects compared to healthy elderly people.

Increased the levels of lycopene and total carotenoid levels in the body do not have a significant impact in reducing the risk of ACOS and BA

Based on the findings, researchers said, "COPD of Japanese patients may develop partly because of oxidative stress derived from a shortage of antioxidant nutrients, especially of AA and lycopene as well as GSH while this may not be the case in both ACOS and BA.".

Taken altogether, lycopene found in tomato may not be considered a remedy for the prevention of overlap syndrome (ACOS) and/or bronchial asthma (BA), pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary lycopene supplementation suppresses Th2 responses and lungeosinophilia in a mouse model of allergic asthma by Hazlewood LC1, Wood LG, Hansbro PM, Foster PS. (PubMed)

Herbal Ashwagandha Modulates the Immune Response

By Kyle J. Norton

The immunomodulatory effect is a process in which the immune function is modulated to the needs of the body.

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.

* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.

In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

Most common symptoms of acute inflammation occurred with a short period of time such as hours is a pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.

Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".

And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for enhancing immune functioning, researchers examined the effects of ashwagandha root extract consumption on the differentially modulated immune response on BALB/c mice.

The study included three selected Withania somnifera chemotypes designated as NMITLI 101R, NMITLI 118R, and NMITLI 128R administered 10-100 mg/kg orally to BALB/c mice once daily for 14 days.

According to the tested assays, all three selected Withania somnifera chemotypes exerted immunomodulatory consequences in the humoral immune response on delayed-type hypersensitivity reaction.

Furthermore, the applications also inhibited the proliferation of T and B cells, intracellular and secreted Th1 and Th2 cytokines along with modulation in ROS production.

Moreover, peritoneal macrophages associated with anti-inflammatory expression was also exhibited by the lower doses (3-30 mg/kg/day) of these three chemotypes injection.

Compared to other chemotypes, the NMITLI 101R has been found to be most effective in the expression of the aforementioned parameters in the immunomodulatory activity.

Based on the findings, researchers said, "it may, therefore, be concluded that there was distinct modulation in the immune response exhibited by the three chemotypes of Withania somnifera and NMITLI 101R appeared to possess a better immunostimulatory activity than the other chemotypes at lower doses.".

Taken altogether, Ashwagandha may be considered an immunomodulatory herb, pending to the result of larger sample size and multicenter study


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S1, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C. (PubMed)
(2) Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs by generating strong IFN-γ and IL-12 mediated immuneresponses in Leishmania donovani infected hamsters by Tripathi CD1, Kushawaha PK2, Sangwan RS3, Mandal C4, Misra-Bhattacharya S1, Dube A. (PubMed)