Turmeric, a Natural Prevention and Treatment of Neuro Inflammation

By Kyle J. Norton

The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.

Neuroinflammation is a process of the immune system that responds to harmful pathogens that induced oxidative stress to the brain.

Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.

Inflammation can be acute or chronic. In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of inflammatory cytokines to kill off micro-organisms that affect the function of the brain, leading to symptoms of fever, redness, and swelling.

Most cases of acute neuroinflammatory may be resolved within a few days without causing damage to the brain tissues.  However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic neuroinflammatory diseases.

Neurodegenerative diseases are the most common forms of low-grade chronic neuroinflammation, including Alzheimer's disease, vascular dementia, and dementia with Lewy bodies.

Dr. WEI-WEI CHEN, the lead scientist at the Xuzhou Central Hospital in the investigation of inflammatory cytokines and chronic neuroinflammation wrote, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia"

And, "These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of neurological disease, researchers examined the efficacy of a classical LPS model included aromatic-turmerone on neuroinflammation.

On LPS-induced neuroinflammation mice and BV2 cells, according to the tested analysis, oral administration of aromatic-turmerone not only reversed LPS-induced memory disturbance but also normalized glucose intake and metabolism in the brains.

The application of the aromatic-turmerone also protected the neuron viability by significantly limited brain damage by inhibiting the generation of inflammatory cytokines.associated with neuro-inflammation and activation of microglia involved in the immune system response to the LPS injection.

In vitro, aromatic-turmerone also targeted Toll-like receptor 4 which plays a key role in the innate immune system.in the mediation of downstream signaling associated with the activation of inflammatory mediators.

Based on the results, researchers said, "aromatic-turmerone is effective in preventing brain damage caused by neuroinflammation and may be useful in the treatment of neuronal inflammatory diseases."

Taken altogether, turmeric may be considered supplements for the prevention and treatment of neuronal inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway by Chen M1, Chang YY1, Huang S1, Xiao LH1, Zhou W1, Zhang LY1, Li C1, Zhou RP2, Tang J3, Lin L4, Du ZY1, Zhang K. (PubMed)
(2) Role of neuroinflammation in neurodegenerative diseases (Review) by WEI-WEI CHEN, XIA ZHANG, and WEN-JUAN HUANG. (PMC)

Phytochemical Betaxanthins Processes Anti-Cancer Activity in Vitro

By Kyle J. Norton

Cancer is a group of cell mutated diseases caused by the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At early, most people with cancer are asymptomatic.

At the later, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort and loss of appetite and localized symptoms such as severe pain and bleeding.

The exact causes of cancer are not identified. However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco and excessive alcohol drinking,.. The list goes on and on, depending on the types of cancer.

Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.

Dr. Karen Basen-Engquist, in the evaluation of obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".

And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".

The findings strong indicated the risk of cancer is increased substantially in obese.

Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

On finding a potent ingredient for the treatment of chronic disease, researchers investigated the effects of the green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. Rubra L.) against cancer.

According to the tested analysis, betaxanthins found in red beetroot accompanied by betacyanins comapred to apigenin, vitexin, vitexin-2-O-xyloside, and vitexin-2-O-rhamnoside found in green beetroot showed considerable antiproliferative activities.

Furthermore, Vitexin-2-O-xyloside, in combination with betaxanthins and betacyanins, exerted antiproliferative activity in breast, liver, colon, and bladder cancer cell lines, through both intrinsic and extrinsic apoptotic pathways.

Genes associated with cancer survival were also inhibited by the aforementioned phytochemicals in both green and red beetroots.

Moreover, the combination of Vitexin-2-O-xyloside, betaxanthins and betacyanins and chemo drugs not only increased the drug anticancer activity but also reduce their toxicity and overcome the multidrug resistance of cancer cells.

Taken altogether, betaxanthins combined with other phytochemicals may be considered an anti-cancer remedy,  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

Green Beans Gobbles Up Prostate Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of diseases associated with abnormal cell growth in a specific tissue of an organ, due to the alternation of DNA.

A primary tumor or original tumor is a tumor of the original site where it first arose and the tumor progression began and proceeded to yield a cancerous mass.

Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance of the body and alter the metabolic pathways, leading to disordered and violent cellular behavior.

 At the early stage, due to the small size of the tumor, most patients are asymptomatic.

Prostate cancer is a medical and chronic condition in which the cells of the prostate have become cancerous due to the alternation of the cell's DNA.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissue and organ, leading secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.

Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

Believe it or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.

Dr. Anton Stangelberger,, the lead scientist at the joint study led by the University of Vienna, wrote, "

Due to increasing life expectancy and the introduction of prostate-specific antigen (PSA) screening, a rising number of elderly men are diagnosed with prostate cancer. Besides PSA serum levels and Gleason score, age is considered to be a key prognostic factor in terms of treatment decisions".


And, " Not every man who is diagnosed with prostate cancer will develop the clinically significant disease. This has led to the concept of expectant management for screen-detected, small-volume, low-grade disease, with the intention of providing therapy for those men with disease progression.".

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belongings to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent compound that processes chemopreventive activity, researchers examined BN999, a fermentation product of soybean, black bean, and green bean mixture in the inhibition of the growth of human prostate cancer.

The application of the mixed product showed a significant effect on inhibiting the growth of prostate adenocarcinoma PC-3 cells without causing obvious side effects.

Furthermore, BN999 induced apoptosis in colon cancer cells without affecting the healthy cells.

Based on the findings, researchers after taking into account co and confounder wrote, "these data suggest that BN999 has the potential to be used as cancer chemoprevention or therapeutic agent".

Taken altogether, green beans used combined with fermentation products of soybean, the black bean may be used as an adjunct therapy for the prevention of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB. (PubMed)
(2) Prostate Cancer in Elderly Men by Anton Stangelberger, MD,* Matthias Waldert, MD,* and Bob Djavan, MD, Ph.D. (PMC)

Antioxidant Lycopene in the Prevention and Treatment of Esophagitis

By Kyle J. Norton

Esophagitis or heartburn or gastroesophageal reflux disease (GERD). is a condition characterized by the going back up of acidic stomach contents to the esophagus.

Most cases of esophagitis are happened immediately after eating causing a burning sensation or pain in the lower chest area.

According to the statistics, in the US, approximately, 20% of people with acid reflux will develop esophagitis.

 More than 65% of people who suffer from acid reflux are 40 years old or older. And, 15 to 30 5 of the U.S. population has esophagitis

There is no single cause of esophagitis. Epidemiologically, eating large meals or lying down right after a meal, snacking close to bedtime, smoking, being overweight or obese, overeating certain foods such as citrus, tomato, chocolate, mint, garlic, onions, or spicy or fatty foods are some prevalent factors associated with the risk of esophagitis

First-time pregnancy women may also experience esophagitis caused by increasing levels of hormones combined with pressure from the growing fetus.

Furthermore, long-term intake of certain medications such as bronchodilators for asthma, progestin for birth control or to treat abnormal menstrual bleeding, sedatives for insomnia and anxiety, calcium channel blockers for high blood pressure.

Dr. Zeynel Mungan and colleagues in examing the medication risk of esophagitis wrote, "Gastroesophageal reflux disease (GERD), which is common in many communities, is associated with structural factors, eating habits, and the use of certain drugs".

And, "The use of such drugs can lead to the emergence of GERD and can also exacerbate existing reflux symptoms. These drugs can contribute to GERD by directly causing mucosal damage, by reducing lower esophageal sphincter pressure (LESP), or by affecting esophagogastric motility".


Therefore, if you currently taking some of the aforementioned medication, please make sure that you know all the side effects for preventive measures.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of esophagitis, researchers examined the role of lycopene (L) on radiation-induced acute esophageal toxicity in an animal model.

60 Wistar albino rats.selected to the study were divided into five groups: control, L, radiotherapy (RT), L before RT (L + RT), and L before and after RT (L + RT + L). 6 mg/kg bw/day with L administered 7 days in the L group, 7 days before RT in the L + RT group, and 7 days before and after in the L + RT + L group.

According to the tested analysis, L levels were significantly higher in the L receiving groups, comapred to RT group.

Esophagitis was significantly worse in the RT group than in the none-RT groups. Injection of lycopene in the L + RT and the L + RT + L groups showed better results than the RT group.

Compared to RT group, grade 2-3 degenerative changes-necrosis and vacuole formation were significantly lesser in the L + RT and the L + RT + L groups.

Furthermore, subepithelial bulla formation and inflammation in the L + RT and the L + RT + L groups were also significantly decreased compared to the RT group.

Moreover, L + RT + L groups exerted the highest decrease to regeneration-mitosis compared to a moderate decrease in the L + RT group, comapred to RT groups.

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of esophagitis, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene in the Prevention of Radiation-Induced Esophagitis by Coskun H1, Andic F1, Daglıoglu YK2, Doran F3, Sahin K4, Tunalı C1, Kucuk O. (PubMed)
(2) Which drugs are risk factors for the development of gastroesophageal reflux disease? by Mungan Z, Pınarbaşı Şimşek B. (PubMed)

Turmeric, a Natural Prevention and Treatment of Chronic Lymphocytic Leukemia

By Kyle J. Norton

Cancer is a class of chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of the specific organ.

Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of organs before penetrating into deeper layers to form a tumor.

At the advanced stage, most cancers can travel through blood and fluid circulation to infect other healthy tissue and organ a distance away from the original site.

Leukemia is a medical condition caused by the abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. 

Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, and leg.

According to the statistics, approximately 176,200 people in the US will be diagnosed with leukemia, lymphoma or myeloma in 2019, accounting for 10% of all new cases of cancer diagnosed in the US.

Chronic lymphocytic leukemia (CLL), type of leukemia associated with a condition of slow growth and spreading of a group of abnormal white blood cells called B-cell lymphocytes, which fight against infection in our body by produced antibodies. 

In CLL, B-cell lymphocytes have become abnormal and grow out of control. They appear less immature in the bloodstream.

Besides the general symptoms shared by all types of leukemia, the most common specific symptoms of CLL are

*Abnormal bruising
It is normally occurred in the later stage of CLL due to immature white blood cells that affect the levels of platelets.

*Enlarged lymph nodes, spleen
In CLL, lymph nodes can swell more than 1cm in children and 2 cm in adult.

* Become too full easily
One of the specific symptoms of CLL due to enlarged lymph nodes or spleen pressing onto the abdomen.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of leukemia, researchers examined the effect of turmeric and the green tea extract epigallocatechin-3-gallate (EGCG) effects on the apoptotic machinery in chronic lymphocytic leukemia (CLL).

According to the tested assays, curcumin induced B-CLL cells apoptosis is associated with a dose-dependent.

Curcumin was more sensitive to its cytotoxic effects than B-CLL cells compared to normal B lymphocytes.

Furthermore, curcumin inhibited the protein (PARP) from doing its repair work in cancer cells and the cell dies in B-CLL cells by activating the programmed cell death gene.

Moreover, curcumin-induced B-CLL cells apoptosis also by the release of cytochrome c from the mitochondrial membrane.

Additionally, the inhibition of B-CLL cells of curcumin was also found in the inhibition of the activation of pro-survival pathways, including STAT3, Akt, and NF-κB.

Interestingly, Co-culture of B-CLL cells with stromal cells, curcumin-induced apoptosis at lower curcumin doses, but not at higher doses (20μM) (2). 

Based on these findings, researchers strongly believed that curcumin alone may be a less effective treatment for B-CLL due to incomplete apoptotic responses. 

In other words, curcumin enhanced the effectiveness of a variety of compounds for the treatment of B-CLL.

Taken altogether, turmeric processed abundantly bioactive compound curcumin combined with conventional medicine or other phytochemicals for the prevention and treatment of chronic lymphocytic leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evidence for and Against Green Tea and Turmeric in the Management of Chronic Lymphocytic Leukemia by Bange E1, Timlin C1, Kabel C2, Svoboda J1, Roeker L2, Mato AR. (PubMed)
(2) Turmeric and green tea: a recipe for B-Chronic Lymphocytic Leukemia by Laura S. Angelo and Razelle Kurzrock. (PMC)
(3) Lymphoblastic leukemia - Chronic lymphocytic leukemia (CLL) by Kyle J. Norton

Cranberry, the Anti Cardiovascular Disease Remedy

By Kyle J. Norton

Cardioprotection is an action that contributes to the protection of heart and blood vessels integrity against damage or injury, including heart diseases, and stroke.

In other words, cardioprotection is a process in which substances or medicines are used including an herbal remedy to protect heart muscle tissues against ischemic insult and deoxygenation injury.

Cardiovascular diseases (CVD) are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.

According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015 were in men, comapred to women.

Believe it or not, more than 63),000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.

On another hand, stroke is a medical condition caused by poor blood flow to the brain, leading to brain cell death in the affected region.

Most common types of stroke are ischemic stroke associated with the obstruction of a blood vessel supplying blood to the brain and hemorrhagic stroke associated with small blood vessel ruptures. Most common cause of stroke is unmanaged high blood pressure.

The US statistics indicated that stroke is the leading cause of long-term disability in the United States. Each year, more than 79o,000 people suffer a stroke, inclduing 600,000 of first attacks, and 185,000  recurrent attacks.

Coronary artery disease caused by narrowing of the arteries, heart attack, abnormal heart rhythms, or arrhythmias and stroke is the most common type of cardiovascular disease found in the Western world.

Most common symptoms of CVD include persistent fatigue, shortness of breath, irregular heartbeat, chest pain, and fainting.

If you have some of the aforementioned symptoms, please make sure that you check with your doctor to rule out the CVD possibility.

The exact causes of cardiovascular diseases are unidentified. However, according to epidemiological studies, the most prevalent factors that cause the increased risk of CVD are an unhealthy lifestyle correlated to the promotion of the Western diet. 

Dr. Oikonomou E and colleagues in the joint study led by the National and Kapodistrian University of Athens wrote, "... Western dietary pattern (increased intake of fat, red meat, and carbohydrates and minimal consumption of fruits and green leafy vegetables) was predictive of severe CAD (area under the curve: 0.73, 95% confidence intervals: 0.64-0.83, P < .001)".

And, "an unhealthy Western type of diet is associated with the severity of coronary artery lesions in patients with stable CAD. These findings highlight the role of dietary patterns when estimating cardiovascular risk for the management of patients with CAD".

The results strongly suggested by lifestyle change have a strong implication in the prevention of CVD.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of heart disease and stroke, researchers examined the efficacy of cranberry supplementation on cardiovascular disease metabolic risk factors in adult populations.

The systematic review is conducted by searching the databases of PubMed, Scopus, Web of Science and Google Scholar up to June 2018, to identify randomized controlled trials investigating the effect of cranberry supplementation on cardiovascular metabolic risk factors.

According to the results from the review of the pooled effect size, cranberry administration decreased the risk of CVD by significantly reducing systolic blood pressure and body mass index.

However, other parameters associated with the metabolic risks such as triacylglycerol, total cholesterol, low-density lipoprotein, high-density lipoprotein, fasting plasma glucose, fasting insulin, homeostasis model assessment of insulin resistance, diastolic blood pressure, waist circumference, C-reactive protein, and intercellular adhesion molecule were not changed much after cranberry administration.

Furthermore, the most reduction of SBP was more pronounced in patients with age ≥50 comapred to the younger age group.

Moreover, comapred to no change in supplemental administration, there was also a significant increase in high-density lipoprotein concentrations in subgroups with subjects <50 mean age and triacylglycerol levels in subsets with cranberry administered in juice form.

Based on the findings, researchers concluded. " cranberry supplementation may be effective in managing systolic blood pressure, body mass index and high-density lipoprotein in younger adults. Further high-quality studies are needed to confirm these results.".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CVD, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of cranberry on cardiovascular metabolic risk factors: A systematic review and meta-analysis by Pourmasoumi M1, Hadi A2, Najafgholizadeh A3, Joukar F4, Mansour-Ghanaei F. (PubMed)
(2) Western Dietary Pattern Is Associated With Severe Coronary Artery Disease by Oikonomou E1, Psaltopoulou T2, Georgiopoulos G1, Siasos G1,3, Kokkou E1, Antonopoulos A1, Vogiatzi G1, Tsalamandris S1, Gennimata V1, Papanikolaou A1, Tousoulis D. (PubMed)

Herbal Ashwagandha Modulates the Immunomodulatory Effects on Colon Cancer Developing

By Kyle J. Norton

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.

Most common symptoms of the underactive immune system are infection including frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections and Inflammation and infection of internal organs.

However, blood disorders, such as low platelet counts or anemia and digestive dysfunction are also some of the common symptoms found in patients with the underactive immune system.

* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.

Dust, mold, pollen, and food over-reaction are some of the most common symptoms of patients with an overactive immune system. However, in severe cases, over the active immune system can attack the body tissues, leading to chronic diseases such as rheumatoid arthritis, systemic lupus erythematosus (lupus), inflammatory bowel disease (IBD), multiple sclerosis (MS) and type I diabetes.

According to the BC health link, autoimmune tests may include anti-dsDNA, anti-RNP, anti-Smith (or anti-Sm), anti-Sjogren's SSA and SSB, anti-scleroderma or anti-Scl-70, anti-Jo-1, and anti-CCP. Antibody against cardiolipin also may be tested depending on the type of symptoms.

In other words, if your tested results showed that you have several of these antibodies in high amounts, you may have an autoimmune disease.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of cancer, researchers examined the effects of Withania somnifera (Ashwagandha) on immunomodulation was tested in experimental azoxymethane-induced colon cancer in an animal model.

The study included Swiss albino mice induced colon cancer by Azoxymethane 15 mg/kg body weight was injected intraperitoneally once a week for 28 days before treatment of Withania somnifera.

According to the tested analysis, Azoxymethane induced the appearance of aberrant crypt foci (ACF) in the colons of the experimental mice. Furthermore, the biomarker and expression of ACF were found to correlate to the development of colon tumors.

Application of 400 mg/kg body weight of W. somnifera extracts once a week for four weeks on orally Azoxymethane induced colon cancer mice showed a significant effect on immunomodulatory activity by significantly altering the level of leucocytes, lymphocytes, neutrophils, immune complexes, and antibody immunoglobulins (Ig) A, G, and M.

In other words, the azoxymethane-induced colon cancer and immune dysfunction were controlled by the application of W. somnifera. 

Based on the findings, researchers said, " These results suggested that the immunomodulatory effects of W. somnifera could be useful in the treatment of colon cancer".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of colon cancer through its immunomodulatory effects, pending to the result of larger sample size and multicenter study



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory effects of Withania somnifera on azoxymethane induced experimental colon cancer in mice by Muralikrishnan G1, Dinda AK, Shakeel F. (PubMed)
(2) Autoimmune Disease Tests. Test Overview by Healthlink BC