Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday 11 September 2019

Turmeric Protects the Neurons Against the Risk of Neurological Disease

By Kyle J. Norton

Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.

Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.

Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.

There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.

Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.

According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema,
inflammations, etc.

On finding a potent compound for the treatment of neurological disease, researchers examined Curcuminoids, polyphenol compounds from turmeric (Curcuma longa) effect on Alzheimer's disease (AD).

According to the tested analysis,

* Curcuminoids attenuation of mitochondrial dysfunction-induced neurons oxidative stress and inflammatory responses in patients with AD.

* The bioactive compound inhibited the immune response in the promotion of the production of pro-inflammatory cytokines such as COX-2, and iNOS

* Furthermore, curcuminoids also bind to β-amyloid (Aβ) plaques to inhibit amyloid accumulation and aggregation in the brain of AD patients.

* More importantly, the expression of the toxic Aβ oligomer formation and oligomer-dependent Aβ toxicity were also inhibited by the injection of curcuminoids.

Curcuminoids efficacy of in patients with AD was also found in diseases associated with multiple sclerosis (MS), glaucoma, age-related macular degeneration (AMD), particularly in the prevention α-synuclein aggregation in Parkinson's disease (PD).

Additionally, neurological damage caused by heavy metal poisoning was also attenuated by the injection of curcuminoids.

Based on the results, researchers wrote, " These results demonstrate curcuminoids may be potentially effective therapeutic means to treat neurodegenerative diseases. A bulk of patents discloses methods to improve the bioavailability of curcuminoids for therapeutic development".

Taken altogether, turmeric processed abundantly bioactive compound curcuminoids may be considered supplements for the prevention and treatment of neurological diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Benefits of curcumin in brain disorders by Bhat A1,2, Mahalakshmi AM1,2, Ray B1,2, Tuladhar S1,2, Hediyal TA1, Manthiannem E1, Padamati J1, Chandra R3,4, Chidambaram SB1,2, Sakharkar MK. (PubMed)
(2) Curcuminoids in neurodegenerative diseases by Kim DS1, Kim JY, Han Y. (PubMed)

Carotenoids Reduce Risk of Lung Cancer

By Kyle J. Norton

The lung is one of the vital organs in human located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells need and exhaling carbon dioxide from the bloodstream.

Lung cancer is a chronic and medical condition characterized by abnormal growth of the cells in the lung's tissue.

Most common form of primary lung cancers is derived from epithelial cells.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease and excessive drinking are some prevalent factors associated with lung cancer developing.

According to the statistics provided by the American cancer society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

Lung cancer can be classified into 2 major types

* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably. Most common types of Non-small cell lung cancer lung cancers include

**Squamous-cell carcinoma often is found in an outer area of the lung.

** Large-cell carcinoma is found in the center of the lung by an air tube.

** Adenocarcinoma is found in any part of the lung.

* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage. Most common types of small cell lung cancer include
* Small cell carcinoma is small, round and resemble oats.

*Mixed small cell/large cell carcinoma is found in combining components of small cell lung carcinoma with large cell lung carcinoma.

*Combined small cell carcinoma is found in combining of a component of small cell lung carcinoma with components of non-small cell lung carcinoma.

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

On finding a potential compound for the treatment of lung cancer, researchers to compare the dietary intake and serum levels of some selected carotenoids of lung cancer patients with healthy subjects.

The case-control study included 35 lung cancer patients and 33 healthy people with a daily intake of nutrients estimated by using a semiquantitative food frequency questionnaire and a 3-day 24-h food recall questionnaire.

According to the tested analysis,

* The beta-carotene and lycopene intake of the case subjects was 96% and 195% higher in the lung participants compared to those of control.

* Daily intake of fruits and vegetables in the cancer group was higher compared to control group.

However, the serum concentration of beta-carotene and lycopene were 118% and 60% higher in the control group compared to the lung cancer group.

These results suggested that there must be some unknown mechanisms associated with the reduced levels of beta-carotene and lycopene in the blood of lung cancer patients.

In other words, the intake of beta-carotene and lycopene daily reduces the risk of lung cancer in healthy individuals.

Dr. Asbaghi S, the lead scientist after taking other factors such as age, gender, smoking habits, weight, body mass index, mean daily energy intake, mean daily fat intake into account wrote, "Despite a higher daily dietary intake of beta-carotene and lycopene by lung cancer patients, serum beta-carotene and lycopene concentrations were significantly lower than the group without cancer".

Taken altogether, carotenoids processed abundantly beta-carotene and lycopene may be considered a remedy for the prevention of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Dietary Intake and Serum Level of Carotenoids in Lung Cancer Patients: A Case-Control Study by Asbaghi S1, Saedisomeolia A, Hosseini M, Honarvar NM, Khosravi A, Azargashb E. (PubMed)
(2) Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF-AICR systematic review of published prospective studies by Abar L1, Vieira AR1, Aune D1,2, Stevens C1, Vingeliene S1, Navarro Rosenblatt DA1, Chan D1, Greenwood DC3, Norat T. (PubMed)
(3) Lung Cancer by Kyle J. Norton

Whole Food Tomatoes, Kills Breast Cancer in Vitro

By Kyle J. Norton

Breast cancer is a medical condition caused by irregular cell growth in the breast tissue.

Breast cancer mostly starts in the cell on the surface of the inner lining of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the later stage, breast cancer can induce secondary metastasis through the circulation of blood and fluids.

Most cases of breast cancer are discovered by the women themselves or their partners.

According to the statistics, In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Today, due to the advanced technology and awareness of the disease, most cases of breast cancer in North American are diagnosed at an early stage.

The 5-year survival rate of breast cancer diagnosed in the local stage is close to 100%.

Most common symptoms at the early stage of breast cancer are lump (mass) in the breast, the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.

In the advanced stage, breast cancer may experience symptoms of bone pain (Secondary tumors in the bone), shortness of breath (Secondary tumors in the lung), unintentional weight loss and drop in appetite, (Secondary tumors in the liver) and headaches, neurological pain or weakness (Secondary tumors in the nervous system).

If you have some of the aforementioned symptoms, please make sure that you check with your doctor to rule out the possibility.

Out of many risk factors associated with breast cancer, some researchers suggested that the promotion of a high-fat diet in inducing the widespread obesity and overweight may have a strong implication on breast cancer.

Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".

And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women and with worse disease outcome for women of all ages".

In other words, if you are obese, your risk of breast cancer increases substantially compared to those who are not.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover a natural chemo remedy for the treatment of breast cancer, researchers examined the InsP 5-ptase fruit extract from tomato effect on breast cancer cells.

According to the Cellular assays, InsP 5-ptase fruit extract was more effective for reducing the proliferation of breast cancer cells compared to wild-type tomato fruit extract.

Breast cancer cells (MCF-7 line) exposed to an extract of transgenic fruits extract inhibited several genes compared to untreated cells or cells treated with wild-type tomato extract, according to the metabolome analysis of InsP 5-ptase.

Researchers after taking into account co and confounders wrote, "Together, this data demonstrates the potential role of the plant-derived metabolites in suppressing cell viability of cancer cells".

In order to reveal more information about tomato anti-breast cancer property, researchers screened and elucidated the potential bioactive lycopene-derived products in breast-cancer and non-cancerous cells.

According to the oxidation products separated from LYC-oxidation as fractions I-III, Fraction II showed higher cytotoxicity (IC50 value of 64.5 μM), cellular uptake, and apoptosis-inducing activity compared to fraction I and III in MCF-7 cells.

ROS exerted cytotoxicity of the fractions are generated by mitochondrial dysfunction in the tested cell line.

Dr. Arathi BP, the lead scientist wrote in the final report, "LYC-oxidation derivatives or metabolites are involved in growth inhibition of cancer cells. Exploration of specific oxidized-carotenoid products will give further insight into the field of nutritional biochemistry".

Taken altogether, tomatoes processed a high amount of lycopene may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells by Alimohammadi M1, Lahiani MH1, McGehee D1, Khodakovskaya M. (PubMed)
(2) Fractionation and Characterization of Lycopene-Oxidation Products by LC-MS/MS (ESI)+ by Elucidation of the Chemopreventative Potency of Oxidized Lycopene in Breast-Cancer Cell Lines by Arathi BP1, Raghavendra-Rao Sowmya P1, Kuriakose GC2, Shilpa S1, Shwetha HJ1, Kumar S3, Raju M4, Baskaran V5, Lakshminarayana R. (PubMed)
(3) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, PhD, 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, PhD. (PMC)

Cucumber Cucurbitacin B, the Chemotherapy Enhancer for the Treatment of Lymphoma

By Kyle J. Norton

Lymphoma is a medical and chronic condition associated with abnormal growth of lymphocytes, a type of white blood cells of the immune system that fight infection.

Lymphocytes included natural killer cells T cells and B cells are found in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body.

The condition can be classified into 2 types

* Non-Hodgkin is the common form of lymphoma found in most patients.

* Hodgkin

According to the statistics, in the US, this year, approximately, 8,000 people will be diagnosed with Hodgkin lymphoma, leading to the death of 1,000 patients with the disease.

Believe it or not, Hodgkin's lymphoma is treatable, especially in its early stages. The 5-year survival rate for all patients diagnosed with Hodgkin's lymphoma is 92%.

Most cases of non-Hodgkin lymphoma are found in adult 65 years of age and over compared to the age of 15 and 40 or older than 55 in Hodgkin lymphoma.

People with a weakened immune system, autoimmunity, viral infectious disease, family history, exposed to benzene and radiotherapy and past history of Hodgkin or non-Hodgkin lymphoma are some of the factors that may increase the risk of the disease.

Some researchers suggested that genetic proposition may have a strong implication with the onset of lymphoma.

Dr. Robert E. Ferrell, the lead scientist wrote, "Hereditary or primary lymphedema is a developmental disorder of the lymphatic system which leads to a disabling and disfiguring swelling of the extremities"

And, " Hereditary lymphedema generally shows an autosomal dominant pattern of inheritance with reduced penetrance, variable expression and variable age at onset".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural and potential compound for the treatment of lymphoma, researchers examined the effect of Cucurbitacin B (CuB) as ATO and STAT3 inhibitor against lymphoma.

Where Arsenic trioxide (ATO) is a chemotherapy drug used for the treatment of acute myeloid leukemia.

And STAT3 is a protein which regulates genes involved in cell growth and division.

Injection of CuB showed to eliminate the apoptosis resistance of Burkitt's lymphoma Ramos cells to ATO synergistically.

In other words, CuB enhanced the drug effects in the inhibition lymphoma, particularly in resistance of Burkitt's lymphoma Ramos cells.

The results were attributed to the bioactive compound in blocking the activation of protein STAT3 associated with cancer cell proliferation and modulating the expression of proteins involved pro and anti-apoptosis.

Interestingly, the combination of CuB and ATO kills cancer cells without causing harm to normal cell lines.

In nude murine lymphoma model, The synergistic effect of the combination of CuB and ATO was once again confirmed which exhibited significant apoptosis induction and tumor growth inhibition.

Dr. Ding X, the lead scientist said, "CuB synergistically enhances the apoptosis-inducing effect of ATO by inhibiting STAT3 phosphorylation in Ramos cells".

Taken altogether, cucumber combined with primary medicine may be used for the treatment of lymphoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells.
Ding X1,2, Chi J1,2, Yang X1,2, Hao J1,2, Liu C1,2, Zhu C1,2, Wang X1,2, Liu X1,2, Niu Y1,2, Ji W3, Chen D4, Wu X. (PubMed)
(2) Hereditary Lymphedema: Evidence for Linkage and Genetic Heterogeneity by Robert E. Ferrell Kara L. Levinson Judith H. Esman Mark A. KimakElizabeth C. Lawrence M. Michael Barmada David N. Finegold. (Oxford Academic)

Tuesday 10 September 2019

Herbal Turmeric, a Natural Prevention and Treatment of Metabolic Syndrome

By Kyle J. Norton

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes, including too much fat around the waist, high blood pressure, triglycerides, and blood sugar, and low HDL cholesterol.

People who have 3 or more aforementioned conditions are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed cardiovascular disease (CVD) and diabetes.

Most common symptoms of metabolic symptoms are depending totally on the clustered conditions, including thirst and urination, fatigue, and blurred vision due to high blood glucose. However, in patients with no condition of hyperglycemia, metabolic syndrome is asymptomatic.

Epidemiologically, aging, ethnicity, obesity, medical condition such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are most risk factors found in patients with the syndrome.

Conventionally, treatment of metabolic syndrome is totally depending on the cluster of condition. People with fat around the waist or obese are recommended to lose weight in a weight management program accompanied by diet change.

Some researchers suggested that the promotion of the Western diet in the US over the past few decades may have a strong effect in inducing the widespread metabolic syndrome.

Dr. Drake I, the lead scientist wrote, "The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up".

And, " In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables, and high-fiber foods is associated with detrimental effects on cardio-metabolic health".

The results clearly suggested if you are following a traditional diet with high fruits and vegetable and fewer in processed food, saturated and trans fat, and red meat accompanied with moderate exercise daily, your risk metabolic syndrome can be decreased substantially.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound which processes an anti metabolic syndrome activity, researchers examined the Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).

The double-blind-randomized-controlled trial included a total of 250 healthy males with MetS randomized to either Black seeds (1.5g/day), Turmeric (2.4g/day), its combination (900mg Black seeds and 1.5g Turmeric/day) or placebo for 8 weeks.

Based on the analysis, compared to the baseline, at 4 weeks, Black seed and Turmeric alone showed improvement the parameters associated with the risk of MetS including the body-mass-index (BMI), waist circumference (WC), and body-fat-percent (BF%).

Furthermore, also at week 4, the combination improved all parameters involved in the risk of MetS, except HDL-cholesterol with lower fasting blood glucose (FBG) and LDL-cholesterol, compared to placebo.

Moreover, at 8 weeks, Black seeds reduced lipids and FBG, whereas turmeric reduced LDL-cholesterol and CRP, compared to placebo.

More importantly, the combination group with 60% dose of the individual herbs showed an improvement in all parameters from baseline, compared placebo.

In other words, the combination showed complete inhibition of all parameters associated with the onset of metabolic syndrome compared the selected inhibition of individual herbal medicine. Black seeds + Turmeric showed much better efficacy than the use of Black seed and Turmeric alone.

Based on the results, researchers said, " The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be used alone or combination with Black seed for the prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial by Amin F1, Islam N2, Anila N3, Gilani AH. (PubMed)
(2) Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats by Amin F1, Gilani AH, Mehmood MH, Siddiqui BS, Khatoon N. (PubMed)
(3) A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome by Drake I1, Sonestedt E1, Ericson U1, Wallström P2, Orho-Melander M. (PubMed)

Coltsfoot (Tussilago farfara) In Reducing the Risk and Progression of Lung Cancer In Vitro

By Kyle J. Norton

Cancer is a class of diseases caused by cells growth and multiplication disorderly and uncontrollably due to the alternation of the DNA.

After colonizing the entire tissues of the specific organ, the oversize tumor cell can travel a distance away from the originated site to invade other healthy tissues, via lymph or blood.

Most advanced stage of cancer may result in the death of the patients.

The lung is a vital organ located near the backbone on either side of the heart with major functions to inhale oxygen from the air to the bloodstream that nourishes the body cells and exhale carbon dioxide from the bloodstream.

Lung cancer is a chronic condition characterized by cell growth irregularly and disorderly in the lung tissue.

Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.

At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to the secondary metastasis.

According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.

Smoking although is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.

Some researchers suggested that lung cancer in many incidences are associated with oxidative stress as found in advanced lung cancer patients.

Dr. Filaire E the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".

And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of lung disease, researchers examined the effects of purified a polysaccharide, TFPB1, from the flower buds of Tussilago farfara on lung cancer.

In vitro, TFPB1 not only inhibited cell proliferation but also induced cancer cell apoptosis in of A549 cells.

More precisely, TFPB1 kills lung cancer cells by inhibiting the expression of kinase and proteins such as phosphorylation of Akt and Bcl-2 expression involved in multiple cellular processes including apoptosis and exhibiting the protein associated with caspase involved in pro-apoptosis such as Bax expression.

Based on the findings, researchers aid, "TFPB1 exhibited anti-proliferative and anti-apoptotic effect partly depending on the suppression of Akt signaling pathway." and "These findings provided us a potential chemotherapeutic strategy for the treatment of human non-small cell lung cancer".

Taken altogether, coltsfoot may be considered a remedy for the treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Structural characterization of a polysaccharide from the flower buds of Tussilago farfara, and its effect on proliferation and apoptosis of A549 human non-small lung cancer cell line by Qu H1, Yang W2, Li J. (PubMed)
(2) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)

Beans, the Best Antioxidants Against Diseases Associated with Oxidative Stress

By Kyle J. Norton

Antioxidants are stable atoms which inhibit oxidation induced by free radicals.

Free radicals are highly unstable atoms. Internally, free radicals are produced by body cell metabolism. Externally, free radical can enter our body from the environment, such as the air we breathe, the food we eat and the water we drink.

In other words, any chemicals compounds or molecules which process an oxygen atom can be free radicals in a chemical reaction with other atoms.

Oxidative stress can either be caused by overexpression of free radicals or depletion of antioxidant enzymes produced by the host.

According to the epidemiological studies, free radicals are dangerous to human health in excessive amount. Overexpression of free radicals induced oxidative stress has been found to damage the lipid, and protein and induce the alternation of healthy cell DNA, inducing the pathogenesis of various disorders and diseases.

Some researchers suggested that by balancing the ratio of free radicals and antioxidants in the body, diseases associated with oxidative stress can be preventable.

Dr. Monica H Carlsen wrote, "A plant-based diet protects against chronic oxidative stress-related diseases. Dietary plants contain variable chemical families and amounts of antioxidants".

And, "there are several thousand-fold differences in antioxidant content of foods. Spices, herbs, and supplements include the most antioxidant-rich products in our study, some exceptionally high. Berries, fruits, nuts, chocolate, vegetables, and products thereof constitute common foods and beverages with high antioxidant values".

Beans are seeds of several genera of the flowering plant family Fabaceae, including the common bean, green bean, and French bean.

On finding a potent veggie for the prevention of diseases associated with oxidative stress, researchers investigated the effects of bean extracts antioxidant activity.

According to the tested differentiation on chemical analysis, polyphenols, such as gallic acid, chlorogenic acid, epicatechin, myricetin, formononetin, caffeic acid, and kaempferol found in the beans exerted a significant antioxidant activity (AA) against to the activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 50% (EC50) ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg.

Furthermore, the extracts also inhibited the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2) cells, human breast cancer cells MCF-7, and A549 NSCLC cell line through its cytotoxic activity without affecting the nearby healthy cells.

Moreover, cooking beans has been found to reduce antioxidant activity only marginally.

Most importantly, all tested beans showed no significant differences in the biological activities within the same variety, before and after cooking.

Based on the findings, researchers said, " Qualitative and quantitative differences in phenolic composition between the groups of beans influenced the biological activities".

In other words, the antioxidant efficacy of beans was attributed by all chemical compounds that work synergistically to inhibit the diseases involved in oxidative stress.

Taken altogether, beans may be used as an adjunct therapy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L.) Endemic Ecotypes of Southern Italy before and after Cooking by Maria Neve Ombra,1 Antonio d’Acierno,1 Filomena Nazzaro,1 RiccardoRiccardi,2 Patrizia Spigno,2 Massimo Zaccardelli,3 Catello Pane,3 MenaMaione,1 and Florinda Fratianni. (Hindawi)
(2) The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide by Carlsen MH1, Halvorsen BL, Holte K, Bøhn SK, Dragland S, Sampson L, Willey C, Senoo H, Umezono Y, Sanada C, Barikmo I, Berhe N, Willett WC, Phillips KM, Jacobs DR Jr, Blomhoff R. (PubMed)