Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Saturday, 24 August 2019

Bromelain Kills Breast Cancer Cells in Vitro

By Kyle J. Norton

Breast cancer is a medical condition characterized by irregular cell growth in the breast tissue due to the alternation of DNA.

Most cases of breast cancer at the early stage start in the cells on the surface of the inner lining of either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At this stage, the patient may first notice as a painless lump in the breast or armpit and most often discovered by herself or her partner.

However, some patients may also experience symptoms of nipple discharge (clear or bloody)
inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and
unusual breast pain or discomfort.

At the advanced stage, besides experiencing symptoms shared commonly with other types of cancer, patients may also notice localized bleeding and severe pain due to the oversize that press on nearby blood vessels and nerves.

According to the U.S. Breast Cancer Statistics, approximately, 1 in 8 U.S. women or 12% will develop invasive breast cancer over the course of her lifetime.

In 2019, an estimated 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer at the early stage is close to 100%.

The causes of breast cancer are not identified. Gender, aging, genetic preposition, family history, never pregnant women and smoking are some breast cancer prevalent risk.

Dr. Bhaskarapillai Binukuma, the lead scientist in the evaluation of diet risk of breast cancer wrote, "Increased consumption of total fat and saturated fat were found to be positively associated with the development of breast cancer".

And, "A moderate inverse association between consumption of n-3 fatty acids and breast cancer risk and a moderate positive association between n-6 fatty acids and breast cancer risk were observed".

In other words, if you are high-fat diet follower, your risk of breast cancer is increased substantially.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient for the treatment of breast cancer, researchers examined the bromelain-functionalized multiple-wall lipid-core nanocapsules (Bro-MLNC-Zn) on breast cancer cell line.

The complex used for the study was formed by a Zn-N chemical bond and a chelate with hydroxyl and carboxyl group.

In human breast cancer cells (MCF-7), the complex at the nanocapsule surface showed an antiproliferative effect by maintaining its proteolytic activity.

Interestingly, Bro-MLNC-Zn showed a reduced dose at 160-folds to exerted a similar effect compared to that of and bromelain solution.

Based on the results, researchers said, "The surface functionalization approach produced an innovative formulation having a much higher antiproliferative effect than the bromelain solution".

In order to reveal more information about bromelain anti-breast cancer activity, researchers investigated the possible synergistic cytotoxic effects of bromelain in combination with cisplatin on MDA-MB-231 human breast cancer cells.

Human MDA-MB-231 cells used in the study were treated with different concentrations (0.24-9.5 µM) of bromelain or cisplatin alone, as well as four different combinations.

According to the results of tested assays, single-agent treatment with cisplatin or bromelain decreases the viability of the MDA-MB-231 cells at 24 and 48 h in a dose- and time-dependent manner.

All combinations displayed synergistic effects against MDA-MB-231 cells at 48 h, particularly with combination 1 (bromelain 2 µM + cisplatin 1.5 µM).

Interestingly, combination 1 also was found to induce breast cancer cells death with a significant decrease in the levels of several apoptotic proteins but an increase of levels of the pro-apoptotic proteins compared with bromelain.

Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast CancerCells (MCF-7) by Oliveira CP1,2, Prado WA3, Lavayen V3, Büttenbender SL3, Beckenkamp A4, Martins BS3, Lüdtke DS3, Campo LF3, Rodembusch FS3, Buffon A4, Pessoa A Jr5, Guterres SS4, Pohlmann AR. (PubMed)
(2) Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro by Pauzi AZ1, Yeap SK2, Abu N1, Lim KL3, Omar AR2, Aziz SA4, Chow AL1, Subramani T1, Tan SG1, Alitheen NB. (PubMed)
(3) Dietary fat and risk of breast cancer by Bhaskarapillai Binukumar

1 and Aleyamma Mathew. (PMC)

Healthy Food Onion ReduceS Risk of Endometrial Cancer

By Kyle J. Norton

The endometrium is the inner lining of the mammalian uterus that is very susceptible to hormone change, particularly in the menstrual cycle.

The endometrium is also a reproductive organ where the implantation takes place. In the absence of periodic hormonal influence, before puberty or following menopause, this tissue has a constant morphology and thickness.

Endometrial cancer, a late adulthood cancer is a medical condition characterized by irregular cells growth that starts in the cell on the surface of the inner endometrial lining of the uterus due to the alternation of cells DNA.

Endometrial cancer is the fourth most common cancer among women worldwide, after breast, lung, and bowel cancer.

According to the statistics provided by the American Cancer Society, in the US, cancer of the endometrium is the most common cancer of the female reproductive organs. In 2019, approximately 61,000 cases of endometrial cancer will be diagnosed.

Most common types of endometrial cancer are
* Adenocarcinomas
Adenocarcinomas accounted for accounts for over 80% of cases of endometrial cancer that begins with irregular cells growth in the surface cells of the inner lining of the endometrium

Women who have an early onset of symptoms of peri-menopause are at a higher risk of adenocarcinomas.

* Uterine sarcoma
Uterine sarcoma, a rare uterine cancer containing malignant cells of the muscle and connective tissue of the uterus, is accounted for only 2 percent of all uterine cancer, including
** Endometrial stromal sarcomas
Endometrial stromal sarcomas are also endometrial cancers originated in the non-glandular connective tissue of the endometrium, with unknown origin.

* Leiomyosarcomas
Leiomyosarcomas is a form of endometrial cancer originated from the smooth muscles of the uterus. Endometrial cancer has a resistant tendency and not very responsive to chemotherapy or radiation.

* Carcinosarcoma
Carcinosarcoma is a type of cancer caused by both epithelial and connective tissues of the uterus.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of endometrial cancer, researchers examined the relationship between onion and garlic intake on endometrial cancer, using data from an Italian case-control study.

According to the data of a multicentre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, the OR of endometrial cancer for successive categories of onion intake were 0.94 for <2 portions/week compared to garlic of 0.89.

The OR of onion intake was decreased to 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, compared to garlic of 0.62.

In other words, onion and garlic showed a significant inverse trend for the risk of endometrial cancer depending on the quality intake per week.

Furthermore, The OR for an increment of one portion (i.e. 80 g) of onions in the risk of endometrial cancer per week was 0.81.

Based on the finding, researchers said, "Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer".

Taken altogether, onion may be considered a remedy for the prevention and treatment of endometrial cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Odds ratio analysis in women with endometrial cancer by Plagens-Rotman K1, Żak E1, Pięta B. (PubMed)
(2) Allium vegetables intake and endometrial cancer risk by Galeone C1, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. (PubMed)
(3) Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton

Friday, 23 August 2019

Cranberry, Inhibits the Progression of Chronic Kidney Disease (CKD)

By Kyle J. Norton

The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.

The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.

Futhermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.

Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.

In other words, kidney disease often has no symptoms until at a very advanced stage.

Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in high number in patients with diabetes, high blood pressure and other disorders.

Acute kidney dysfunction or acute kidneys failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidneys dysfunction can be cured if the causes are found.

Most cases of acute kidney dysfunction may be associated with toxin accumulated in the kidney organs, leading to the condition of nephrotoxicity.

Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or overdose of certain medications.

Some researchers suggested that people with diabetes are at an increased risk of chronic kidney disease, particularly in those with hyperglycemia.

The National Kidney Foundation wrote, "Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. The strict control of blood sugar levels and reduction of dietary protein intake are also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of renal disease, researchers examined the effect Vaccinium macrocarpon (Dandelion)and Taraxacum officinale (Cranberry) on spontaneous feline chronic kidney disease.

The study included 34 neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) containing 60-80% hydrolyzed proteins, 20-40% minerals and active substances (Lespedeza spp. 0.0588, Vaccinium macrocarpon 0.0371%, and Taraxacum officinale 0.0231%.) for 90 days.

According to tested analysis, both showed a significant effect on the reduced symptoms.

Cats that received the ND exerted a significant decrease of creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase. The elevated levels of the aforementioned parameters have been found persistently in patients with chronic kidney disease.

Furthermore, urine turbidity score, color score, and total proteins associated with the progression of CKD in cats that received the ND were also decreased substantially.

Collectively, researchers after taking other factors into account said, "An ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CKD, particularly in the combination with dandelion and Lespedeza spp, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberries - potential benefits in patients with chronic kidney disease by de Almeida Alvarenga L 1, Borges NA, Moreira LSG, Resende Teixeira KT, Carraro-Eduardo JC, Dai L, Stenvinkel P, Lindholm B, Mafra D. (PubMed)
(2) A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease by Di Cerbo A1,2, Iannitti T3, Guidetti G4, Centenaro S4, Canello S5, Cocco R. (PubMed)
(3) DIABETES AND CHRONIC KIDNEY DISEASE by The National Kidney Foundation

Broccoli Protects the Pancreatic Tissue Damage Induced by Oxidative Stress

By Kyle J. Norton

Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radical that cannot be stopped.

In other words, overexpression of free radicals and depletion of antioxidants are the major cause of oxidative stress.

More precisely, oxidative stress is a result of a long-term imbalance of the ratio of free radicals and antioxidant produced by the host.

Free radicals are highly reactive atoms with a single unpaired electron in an outermost shell with a function to donate or intercepts an electron from other stable atoms, leading to a chain reaction that induces oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA and RNA,..,

Antioxidants are stable atoms that inhibit oxidation.

Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.

Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.

In a healthy individual, antioxidants produced by the body are good enough to prevent the onset of oxidative stress. However, im people with a weakened immune system, intake of dietary antioxidants such as supplements of antioxidant-rich food may be necessary.

Dr. Biller-Takahashi JD, the lead scientist at the joint study led by the UNESP Univ Estadual Paulista wrote, "short-term supplementation with 0.6 mg Se-yeast kg(-1) reestablished the antioxidative status, allowing the production of innate components which can boost immunity without the risk of oxidative stress".

Broccoli is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

On findings a potent and natural compound to prevention pancreatic tissue damage in diabetes, scientists investigated the potential hypoglycaemic and antioxidant properties of aqueous broccoli extracts (BEs) in diabetic rats.

Rats selected to the study induced diabetes by a single intraperitoneal injection dose of 50 mg/kg body weight of Streptozotocin (STZ) drug were co-administration with or without BEs.

After 8 weeks, based on the blood analysis, diabetic rats without co-administration with BEs showed significantly higher levels of pancreatic cells DNA damage, depletion of levels of antioxidant GSH and impaired antioxidant capacity (TAC) levels, compared to non-diabetics.

Furthermore, diabetes rat without co-administration with BEs also demonstrated significant pancreatic tissues damage.

Diabetes rats with BEs co-administration not only reduced all parameters expression but also protected the pancreatic tissue against histopathological changes.

In other words, BEs reduced the damage of pancreas tissue caused by STZ induced hyperglycemia and oxidative injury by enhancing the production of antioxidant enzymes in the tested rats.

Based on the findings, researchers said, "The used in vivo model confirmed the efficacy of BE as an anti-diabetic herbal medicine and provided insights into the capacity of BE to be used for phytoremediation purposes for human type 2 diabetes".

Taken altogether, broccoli may be considered a functional food for the prevention of oxidative stress-induced pancreatic tissue damage, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli (Brassica oleracea) Reduces Oxidative Damage to Pancreatic Tissue and Combats Hyperglycaemia in Diabetic Rats by Suresh S1, Waly MI1, Rahman MS1, Guizani N1, Al-Kindi MAB2, Al-Issaei HKA2, Al-Maskari SNM3, Al-Ruqaishi BRS3, Al-Salami A. (PubMed)
(2) The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus by Biller-Takahashi JD1, Takahashi LS2, Mingatto FE3, Urbinati EC. (PubMed)

Herbal Ashwagandha Arrests Prostate Cancer In Vitro

By Kyle J. Norton

Cancer is a group of chronic diseases caused by irregular cell growth in the specific tissue of an organ due to DNA alternation.

Most cases of cancer start in the cell of the surface of the inner lining tissue before penetrating into deeper layers to form a tumor.

However, as cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cell can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of an enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction, blood in the urine and blood in the seminal fluid.

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome and genetic proposition are some prevalent factors found in patients with the condition.

Conventionally, treatments of prostate cancer are totally depending on the type, stage, and grade accompanied by the patient overall health, age and life expectancy.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

Researchers on finding a potent and natural ingredient for the treatment of prostate cancer investigated the effects of Withania extracts on highly metastatic, androgen-independent prostate cancer cell line (PC3).

According to the results obtained from tested differentiation, the extracts demonstrated strong inhibitory activity in decreasing the cancer cell viability with a half-maximal inhibitory concentration (IC50) of 10 μg/mL.

The sample of prostate tissue and in PC3 cells also exhibited the predominantly high expression levels of IL-8 associated with the production chemokine produced by macrophages and COX-2 involved in the contribution of immune evasion and resistance to cancer immunotherapy were also suppressed by the lowest dose of W. somnifera in 24 hours.

Furthermore, the extract induced cycle arrest of the cancer cell line at the cell cycle in G2/M phase, observed from the rapid accumulation of PC3 cells significantly.

Moreover, W. somnifera extracts suppressed the PC3 inherent metastatic activity.

Based on the results, researchers wrote, "W. somnifera may be a good therapeutic agent in addition to the existing drugs for PC".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of prostate cancer, pending to the confirmation of larger size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells by Rehman S1, Keefover-Ring K2, Haq IU3, Dilshad E4, Khan MI5, Akhtar N6, Mirza B. (PubMed)
(2) Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression by Setty Balakrishnan A1, Nathan AA1, Kumar M1, Ramamoorthy S2, Ramia Mothilal SK. (PubMed)

Indicaxanthin Inhibits the Gene Associated with Colon Cancer Developing

By Kyle J. Norton

The colon formed part of the digestive system, is the 2nd part of intestines found in the large bowel consisting of the colon and rectum. The colon plays a critical role to absorb water from the small bowel contents and breaks down certain materials in the feces into substances in which some of them are reabsorbed and reused by the body.

Cancer is a class of chronic disease caused by cell DNA alternation in the tissue of a specific organ.
The invasive tumor tends to spread to other nearby healthy tissue compared to a noninvasive and benign tumor.

Colon cancer is a chronic condition characterized by irregular cell growth that starts in the cells in the inner lining the tissues of the colon tissues, after penetrating into deeper layers to form a tumor, through the unlimited cell cycle division.

Colon cancer is relatively very common, slowly growing and progressing in a predictable way.

However, at the advanced stage, colon cancerous cell can travel a distance away to invade other healthy tissue, leading to secondary metastasis.

Together with rectal cancer, colorectal cancer is the third most commonly diagnosed cancer in Western countries, including the US and Canada.

According to the statistics, the lifetime risk of developing colon cancer is about one in 23. Colon cancer accounts for 71% of all cases of colorectal cancer. The overall 5 years survival rate of localized colon cancer is 90%.

The 5-year survival rate of colon cancer is 90%. Only 39% of patients are diagnosed in the localized stage.

Dr. Bandaru S. Reddy, in examining the types and amount of dietary fat and colon cancer risk wrote, "The role of types of dietary fat, especially saturated fats of animal origin, n−6- and n−3-rich polyunsaturated fatty acids (PUFAs) in the etiology of colorectal cancer has become increasingly apparent".

And, "Epidemiological studies indicate a positive association between the dietary intake of saturated fat and/or animal fat and colon cancer risk and an inverse relationship between the intake of fish and fish oil rich in n−3 PUFAs and colon cancer development".

In other words, if you follow the Western diet, you are at an increased risk of colon cancer.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potent compound for the treatment of cancer, researchers examined the potential influence of consistent dietary concentrations of indicaxanthin on LOVO1, CACO2, HT29, HCT116, and DLD1 cells.

According to the tested analysis, Indicaxanthin exerted a significant anti-proliferative activity in all cell lines but HT29 by inhibiting some methylation-silenced onco-suppressor genes.

In other words, Indicaxanthin normalized the gene expression associated with cancer cells suppression without affecting the function of basally hypermethylated such as SFRP1 and HPP1.

Interesting, indicaxanthin increased the DNA Methyltransferases (DNMT) gene expression but decrease the activity involved in the promotion of varies types of cancer, including colon cancer.

Most importantly, Indicaxanthin also increased the expression of genes involved in DNA demethylation associated with the activity of unwanted DNA methyltransferase induced tumor progression.

Based on the findings, researchers said, "contribute to new knowledge in the field of phytochemicals and specifically suggest dietary indicaxanthin as a potential epigenetic agent to protect colon cells against tumoral alterations".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity by Naselli F1, Belshaw NJ, Gentile C, Tutone M, Tesoriere L, Livrea MA, Caradonna F. (PubMed)
(2) Types and amount of dietary fat and colon cancer risk: Prevention by omega-3 fatty acid-rich diets by Bandaru S. Reddy. (PMC)

Thursday, 22 August 2019

Turmeric Gobbles Up Plaques Against the Risk of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a medical condition caused by the plaque accumulated on the arterial wall, leading to stiffing and hardening arteries.

The condition is a leading cause of heart disease and stroke, depending on the area of blocking in the arteries.

Arteries are the blood vessels that carry the oxygen-rich blood to the heart and other parts of the body.

Plaque is a combination of cholesterol, calcium, cadmium and other harmful chemical substances found in the blood.

According to statistics, atherosclerosis is the leading cause of 50% of all deaths in Western society.

The exact causes of atherosclerosis are not identified. However, epidemiological studies suggested, damage or injury of the inner layer of an artery, high blood pressure and cholesterol and medical conditions such as arthritis, lupus or infections, or inflammation of unknown cause are some of the most prevalent factors found in patients with atherosclerosis.

Most common symptoms of atherosclerosis are chest pain or angina, pain in the leg, arm, shortness of breath, fatigue.

If the blockage occurs in the brain, confusion, atherosclerosis may induce neurological symptoms such as confusion, muscle weakness, facial pain, and impaired vision.

Some researchers by examing the formation of plaque associated with high blood cholesterol in patients with atherosclerosis suggested a healthy diet high in polyunsaturated fat may have a strong impact on inducing the risk of atherosclerosis

Dr. William E. Connor and colleagues wrote, "the fat content of seafood is largely polyunsaturated, fish and shellfish are commonly recommended in diets designed to reduce serum cholesterol levels and to treat atherosclerosis in man".
And, " At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".

And, "Eighteen recently published articles and books, without exception, stress the preferential use of fish and shellfish in diets for the treatment of coronary heart disease".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of heart disease, researchers examined the effect of an ethanol-aqueous extract obtained from rhizomes of C. longa on LDL oxidation susceptibility and plasma lipids in atherosclerotic rabbits.

The study included a total of 18 rabbits fed for 7 weeks on a diet containing 95.7% standard chow, 3% lard and 1. 3% cholesterol, to induce atherosclerosis then divided into groups, two of which were also orally treated with turmeric extract at doses of 1.66 (group A) and 3.2 (group B) mg/kg body weight, respectively and control.

According to the tested analysis, the low dosage of turmeric extract showed much higher efficacy in decreasing the susceptibility of LDL to lipid peroxidation compared to that of higher dosages.

However, both curcumin extracts doses demonstrated lower levels of total plasma cholesterol compared to the control group.

Furthermore, compared to the higher dose, the lower dosage not only lowered the lower levels of cholesterol but also levels of phospholipids and triglycerides in LDL.

In other words, curcumin protected the arteries against the plaques accumulated on the wall to initiate the risk of atherosclerosis.

After taking others into account, Dr. Ramírez-Tortosa MC, wrote in the final report, " The use of this extract could be useful in the management of cardiovascular disease in which atherosclerosis is important.".

Taken altogether, turmeric may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis by Ramírez-Tortosa MC1, Mesa MD, Aguilera MC, Quiles JL, Baró L, Ramirez-Tortosa CL, Martinez-Victoria E, Gil A. (PubMed)
(2) Effects of the antioxidant turmeric on lipoprotein peroxides: Implications for the prevention of atherosclerosis by Ramirez Bosca A, Carrión Gutierrez MA, Soler A, Puerta C, Diez A, Quintanilla E, Bernd A, Miquel J. (PubMed)
(3) Production of Hypercholesterolemia and Atherosclerosis in Rabbits by a Diet Rich in Shellfish by William E. Connor, M.D., F.A.C.P.; Jay J. Rohwedder, M.D.; John C. Hoak, M.D. (ACP)