Cranberry, Inhibits the Progression of Chronic Kidney Disease (CKD)

By Kyle J. Norton

The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.

The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.

Futhermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.

Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of  10% do not show signs of kidney dysfunction and symptoms.

In other words, kidney disease often has no symptoms until at a very advanced stage.

Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in high number in patients with diabetes, high blood pressure and other disorders.


Acute kidney dysfunction or acute kidneys failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidneys dysfunction can be cured if the causes are found.

Most cases of acute kidney dysfunction may be associated with toxin accumulated in the kidney organs, leading to the condition of nephrotoxicity.

Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or overdose of certain medications.

Some researchers suggested that people with diabetes are at an increased risk of chronic kidney disease, particularly in those with hyperglycemia.

The National Kidney Foundation wrote, "Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. The strict control of blood sugar levels and reduction of dietary protein intake are also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of renal disease, researchers examined the effect Vaccinium macrocarpon (Dandelion)and Taraxacum officinale (Cranberry) on spontaneous feline chronic kidney disease.

The study included 34 neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) containing 60-80% hydrolyzed proteins, 20-40% minerals and active substances (Lespedeza spp. 0.0588, Vaccinium macrocarpon 0.0371%, and Taraxacum officinale 0.0231%.) for 90 days.

According to tested analysis, both showed a significant effect on the reduced symptoms.

Cats that received the ND exerted a significant decrease of creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase. The elevated levels of the aforementioned parameters have been found persistently in patients with chronic kidney disease.

Furthermore, urine turbidity score, color score, and total proteins associated with the progression of CKD in cats that received the ND were also decreased substantially.

Collectively, researchers after taking other factors into account said, "An ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CKD, particularly in the combination with dandelion and Lespedeza spp, pending to the confirmation of the larger sample size and multicenter human study.


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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Cranberries - potential benefits in patients with chronic kidney disease by de Almeida Alvarenga L 1, Borges NA, Moreira LSG, Resende Teixeira KT, Carraro-Eduardo JC, Dai L, Stenvinkel P, Lindholm B, Mafra D. (PubMed)
(2) A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease by Di Cerbo A1,2, Iannitti T3, Guidetti G4, Centenaro S4, Canello S5, Cocco R. (PubMed)
(3) DIABETES AND CHRONIC KIDNEY DISEASE by The National Kidney Foundation

Broccoli Protects the Pancreatic Tissue Damage Induced by Oxidative Stress

By Kyle J. Norton

Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radical that cannot be stopped.

In other words, overexpression of free radicals and depletion of antioxidants are the major cause of oxidative stress.

More precisely, oxidative stress is a result of a long-term imbalance of the ratio of free radicals and antioxidant produced by the host.

Free radicals are highly reactive atoms with a single unpaired electron in an outermost shell with a function to donate or intercepts an electron from other stable atoms, leading to a chain reaction that induces oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA and RNA,..,

Antioxidants are stable atoms that inhibit oxidation.

Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.

Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.

In a healthy individual, antioxidants produced by the body are good enough to prevent the onset of oxidative stress. However, im people with a weakened immune system, intake of dietary antioxidants such as supplements of antioxidant-rich food may be necessary.

Dr. Biller-Takahashi JD, the lead scientist at the joint study led by the UNESP Univ Estadual Paulista wrote, "short-term supplementation with 0.6 mg Se-yeast kg(-1) reestablished the antioxidative status, allowing the production of innate components which can boost immunity without the risk of oxidative stress".

Broccoli is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

On findings a potent and natural compound to prevention pancreatic tissue damage in diabetes, scientists investigated the potential hypoglycaemic and antioxidant properties of aqueous broccoli extracts (BEs) in diabetic rats.

Rats selected to the study induced diabetes by a single intraperitoneal injection dose of 50 mg/kg body weight of Streptozotocin (STZ) drug were co-administration with or without BEs.

After 8 weeks, based on the blood analysis, diabetic rats without co-administration with BEs showed significantly higher levels of pancreatic cells DNA damage, depletion of levels of antioxidant GSH and impaired antioxidant capacity (TAC) levels, compared to non-diabetics.

Furthermore, diabetes rat without co-administration with BEs also demonstrated significant pancreatic tissues damage.

Diabetes rats with BEs co-administration not only reduced all parameters expression but also protected the pancreatic tissue against histopathological changes.

In other words, BEs reduced the damage of pancreas tissue caused by STZ induced hyperglycemia and oxidative injury by enhancing the production of antioxidant enzymes in the tested rats.

Based on the findings, researchers said, "The used in vivo model confirmed the efficacy of BE as an anti-diabetic herbal medicine and provided insights into the capacity of BE to be used for phytoremediation purposes for human type 2 diabetes".

Taken altogether, broccoli may be considered a functional food for the prevention of oxidative stress-induced pancreatic tissue damage, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli (Brassica oleracea) Reduces Oxidative Damage to Pancreatic Tissue and Combats Hyperglycaemia in Diabetic Rats by Suresh S1, Waly MI1, Rahman MS1, Guizani N1, Al-Kindi MAB2, Al-Issaei HKA2, Al-Maskari SNM3, Al-Ruqaishi BRS3, Al-Salami A. (PubMed)
(2) The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus by Biller-Takahashi JD1, Takahashi LS2, Mingatto FE3, Urbinati EC. (PubMed)

Herbal Ashwagandha Arrests Prostate Cancer In Vitro

By Kyle J. Norton

Cancer is a group of chronic diseases caused by irregular cell growth in the specific tissue of an organ due to DNA alternation.

Most cases of cancer start in the cell of the surface of the inner lining tissue before penetrating into deeper layers to form a tumor.

However, as cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cell can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of an enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction, blood in the urine and blood in the seminal fluid.

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome and genetic proposition are some prevalent factors found in patients with the condition.

Conventionally, treatments of prostate cancer are totally depending on the type, stage, and grade accompanied by the patient overall health, age and life expectancy.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

Researchers on finding a potent and natural ingredient for the treatment of prostate cancer investigated the effects of Withania extracts on highly metastatic, androgen-independent prostate cancer cell line (PC3).

According to the results obtained from tested differentiation, the extracts demonstrated strong inhibitory activity in decreasing the cancer cell viability with a half-maximal inhibitory concentration (IC50) of 10 μg/mL.

The sample of prostate tissue and in PC3 cells also exhibited the predominantly high expression levels of IL-8 associated with the production chemokine produced by macrophages and COX-2 involved in the contribution of immune evasion and resistance to cancer immunotherapy were also suppressed by the lowest dose of W. somnifera in 24 hours.

Furthermore, the extract induced cycle arrest of the cancer cell line at the cell cycle in G2/M phase, observed from the rapid accumulation of PC3 cells significantly.

Moreover, W. somnifera extracts suppressed the PC3 inherent metastatic activity.

Based on the results, researchers wrote, "W. somnifera may be a good therapeutic agent in addition to the existing drugs for PC".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of prostate cancer, pending to the confirmation of larger size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells by Rehman S1, Keefover-Ring K2, Haq IU3, Dilshad E4, Khan MI5, Akhtar N6, Mirza B. (PubMed)
(2) Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression by Setty Balakrishnan A1, Nathan AA1, Kumar M1, Ramamoorthy S2, Ramia Mothilal SK. (PubMed)

Indicaxanthin Inhibits the Gene Associated with Colon Cancer Developing

By Kyle J. Norton

The colon formed part of the digestive system, is the 2nd part of intestines found in the large bowel consisting of the colon and rectum. The colon plays a critical role to absorb water from the small bowel contents and breaks down certain materials in the feces into substances in which some of them are reabsorbed and reused by the body.

Cancer is a class of chronic disease caused by cell DNA alternation in the tissue of a specific organ.
The invasive tumor tends to spread to other nearby healthy tissue compared to a noninvasive and benign tumor.

Colon cancer is a chronic condition characterized by irregular cell growth that starts in the cells in the inner lining the tissues of the colon tissues, after penetrating into deeper layers to form a tumor, through the unlimited cell cycle division.

Colon cancer is relatively very common, slowly growing and progressing in a predictable way.

However, at the advanced stage, colon cancerous cell can travel a distance away to invade other healthy tissue, leading to secondary metastasis.

Together with rectal cancer, colorectal cancer is the third most commonly diagnosed cancer in Western countries, including the US and Canada.

According to the statistics, the lifetime risk of developing colon cancer is about one in 23. Colon cancer accounts for 71% of all cases of colorectal cancer. The overall 5 years survival rate of localized colon cancer is 90%.

The 5-year survival rate of colon cancer is 90%. Only 39% of patients are diagnosed in the localized stage.

Dr. Bandaru S. Reddy, in examining the types and amount of dietary fat and colon cancer risk wrote, "The role of types of dietary fat, especially saturated fats of animal origin, n−6- and n−3-rich polyunsaturated fatty acids (PUFAs) in the etiology of colorectal cancer has become increasingly apparent".

And, "Epidemiological studies indicate a positive association between the dietary intake of saturated fat and/or animal fat and colon cancer risk and an inverse relationship between the intake of fish and fish oil rich in n−3 PUFAs and colon cancer development".

In other words, if you follow the Western diet, you are at an increased risk of colon cancer.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potent compound for the treatment of cancer, researchers examined the potential influence of consistent dietary concentrations of indicaxanthin on LOVO1, CACO2, HT29, HCT116, and DLD1 cells.

According to the tested analysis, Indicaxanthin exerted a significant anti-proliferative activity in all cell lines but HT29 by inhibiting some methylation-silenced onco-suppressor genes.

In other words, Indicaxanthin normalized the gene expression associated with cancer cells suppression without affecting the function of basally hypermethylated such as SFRP1 and HPP1.

Interesting, indicaxanthin increased the DNA Methyltransferases (DNMT) gene expression but decrease the activity involved in the promotion of varies types of cancer, including colon cancer.

Most importantly, Indicaxanthin also increased the expression of genes involved in DNA demethylation associated with the activity of unwanted DNA methyltransferase induced tumor progression.

Based on the findings, researchers said, "contribute to new knowledge in the field of phytochemicals and specifically suggest dietary indicaxanthin as a potential epigenetic agent to protect colon cells against tumoral alterations".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity by Naselli F1, Belshaw NJ, Gentile C, Tutone M, Tesoriere L, Livrea MA, Caradonna F. (PubMed)
(2) Types and amount of dietary fat and colon cancer risk: Prevention by omega-3 fatty acid-rich diets by Bandaru S. Reddy. (PMC)

Turmeric Gobbles Up Plaques Against the Risk of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a medical condition caused by the plaque accumulated on the arterial wall,  leading to stiffing and hardening arteries.

 The condition is a leading cause of heart disease and stroke, depending on the area of blocking in the arteries.

Arteries are the blood vessels that carry the oxygen-rich blood to the heart and other parts of the body.

Plaque is a combination of cholesterol, calcium, cadmium and other harmful chemical substances found in the blood.

According to statistics, atherosclerosis is the leading cause of 50% of all deaths in Western society. 

The exact causes of atherosclerosis are not identified. However, epidemiological studies suggested, damage or injury of the inner layer of an artery, high blood pressure and cholesterol and medical conditions such as arthritis, lupus or infections, or inflammation of unknown cause are some of the most prevalent factors found in patients with atherosclerosis.

Most common symptoms of atherosclerosis are chest pain or angina, pain in the leg, arm, shortness of breath, fatigue.

If the blockage occurs in the brain, confusion, atherosclerosis may induce neurological symptoms such as confusion, muscle weakness, facial pain, and impaired vision.

Some researchers by examing the formation of plaque associated with high blood cholesterol in patients with atherosclerosis suggested a healthy diet high in polyunsaturated fat may have a strong impact on inducing the risk of atherosclerosis

Dr. William E. Connor and colleagues wrote, "the fat content of seafood is largely polyunsaturated, fish and shellfish are commonly recommended in diets designed to reduce serum cholesterol levels and to treat atherosclerosis in man".
And, " At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".

And, "Eighteen recently published articles and books, without exception, stress the preferential use of fish and shellfish in diets for the treatment of coronary heart disease".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of heart disease, researchers examined the effect of an ethanol-aqueous extract obtained from rhizomes of C. longa on LDL oxidation susceptibility and plasma lipids in atherosclerotic rabbits.

The study included a total of 18 rabbits fed for 7 weeks on a diet containing 95.7% standard chow, 3% lard and 1. 3% cholesterol, to induce atherosclerosis then divided into groups, two of which were also orally treated with turmeric extract at doses of 1.66 (group A) and 3.2 (group B) mg/kg body weight, respectively and control.

According to the tested analysis, the low dosage of turmeric extract showed much higher efficacy in decreasing the susceptibility of LDL to lipid peroxidation compared to that of higher dosages.

However, both curcumin extracts doses demonstrated lower levels of total plasma cholesterol compared to the control group.

Furthermore, compared to the higher dose, the lower dosage not only lowered the lower levels of cholesterol but also levels of phospholipids and triglycerides in LDL.

In other words, curcumin protected the arteries against the plaques accumulated on the wall to initiate the risk of atherosclerosis.

After taking others into account, Dr. Ramírez-Tortosa MC, wrote in the final report, " The use of this extract could be useful in the management of cardiovascular disease in which atherosclerosis is important.".

Taken altogether, turmeric may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis by Ramírez-Tortosa MC1, Mesa MD, Aguilera MC, Quiles JL, Baró L, Ramirez-Tortosa CL, Martinez-Victoria E, Gil A. (PubMed)
(2) Effects of the antioxidant turmeric on lipoprotein peroxides: Implications for the prevention of atherosclerosis by Ramirez Bosca A, Carrión Gutierrez MA, Soler A, Puerta C, Diez A, Quintanilla E, Bernd A, Miquel J. (PubMed)
(3) Production of Hypercholesterolemia and Atherosclerosis in Rabbits by a Diet Rich in Shellfish by William E. Connor, M.D., F.A.C.P.; Jay J. Rohwedder, M.D.; John C. Hoak, M.D. (ACP)

Lycopene Protects the Ovarian Function in Diabetes

By Kyle J. Norton

Type I diabetes is also known as juvenile diabetes or insulin-dependent diabetes associated with not enough or no insulin produced by the pancreas due to the die-off or gradual die-off the insulin-producing beta cells.

The exact causes of type I diabetes are not identified. However, the condition is a result of the body's own immune system that mistakenly destroys the insulin-producing cells in the pancreas.

Type II diabetes is a chronic acquired medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.

The disease is either caused by cells in pancreas die-off or receptor sites clog-up by fat and cholesterol induced by long-term poor diet.

Diabetes complications are caused by long-term poor management of hyperglycemia. Mismanaged diabetes can result in dangerous complications.

Hyperglycemia is a hallmark of type 2 diabetes characterized by an abnormally high level of glucose in the blood. The other hallmark of diabetes is insulin resistance.

The ovary formed part of the reproductive gland held by a membrane beside the uterus on each side of the lower abdomen. The left and right ovary take a turn to release an age each month.

Ovarian dysfunction associated with diabetics triggers abnormal ovarian morphology has been found in diabetics.

Dr. Yanqing Wu and colleagues wrote, "(in mice fed with high-fat-diet-induced diabetes) Elevated markers of DNA damage, ER stress, and apoptosis of GCs were observed in ovaries from HFD for 20 weeks.

And, "Additionally, diabetes significantly suppressed ovarian angiogenesis with the evidence of down-regulation of CD31 via inhibiting HIF1α-VEGF signaling pathway in time-dependent".

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On findings a potential compound for the treatment of diabetes, researchers examined the protective role of lycopene in experimental diabetes-induced with 50 mg÷kg streptozotocin.

The study included rats that were randomly divided into four groups, as follows: control + corn oil, control + lycopene, diabetes + corn oil and diabetes + lycopene.

Based on the tested differentiation, the formation of vacuoles within or adjacent to cells, of the corpus luteum, hydropic degeneration in the interstitial regions, and the number of corpora lutea were increased in the ovary in diabetes rats.

The diameter of the corpora lutea in diabetic rats was also decreased.

Additionally, the levels of ovarian stress markers such as malondialdehyde levels and the number of apoptotic cells in the granulose layers of the large antral follicles were increased in diabetic rats.

These results strongly suggested that streptozotocin-induced significant damage and injury of the ovary in the experimental rats, leading to reduced function of the ovaries.

Administration of lycopene increased the expression of connexin-43 associated with the ovarian cell communication between cells to regulate cell integrity and viability in the secondary and large antral follicles in the ovaries of diabetic animals.

More precisely, lycopene inhibited the ovairan change in diabetic rats.

Based on the findings, researchers said, "The changes caused by diabetes in the ovaries and the protective role of lycopene in some but not all parameters were revealed".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention of ovarian damage and injury, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Changes in rat ovary with experimentally induced diabetes and the effects of lycopene on those changes by Yildiz M1, Sandikci M. (PubMed)
(2) Protective effect and mechanism of lycopene on endothelial progenitor cells (EPCs) from type 2 diabetes mellitus rats by Zeng YC1, Peng LS2, Zou L3, Huang SF4, Xie Y5, Mu GP6, Zeng XH7, Zhou XL1, Zeng YC. (PubMed)
(3) Diabetes Induces Abnormal Ovarian Function via Triggering Apoptosis of Granulosa Cells and Suppressing Ovarian Angiogenesis by Yanqing Wu,Yi Yang Li, Xinghui Liao, Zhengchao Wang, Rui Li, Shuang Zou, Ting Jiang, Bingbing Zheng, Ping Duan, and Jian Xiao. (PMC)

Healthy Food Onion, the Potent Antioxidants

By Kyle J. Norton

Antioxidants are stable molecules that inhibit oxidation.

Antioxidant enzymes either produced by the host body or from the dietary sources plays a critical role in the prevention of oxidative stress by balancing the expression of free radicals.

Free radicals are everywhere.  Any chemical containing oxygen molecules including environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.

Free radical internally are produced during the course of cell metabolism.

Oxidative stress is caused by overexpression of free radicals compared to the low levels of antioxidant enzymes produced by the host. Over time, oxidative stress can induce proteins, lipids, and cell damage, leading to the facilitation of heart diseases, diabetes, stroke, cancer...

In other words, the chain reaction of free radical that cannot be stopped is a leading cause of oxidative stress-induced chronic disease.

More precisely, if the antioxidant enzymes no longer can perform the function to balance the free radicals in the body, oxidative stress occurs.

Some researchers suggested the rise of oxidative stress in the US may be correlated to the promotion of the Western diet over the past few decades.

Dr. Ildiko Erdelyi wrote, "WD induces inflammatory changes, expression profiles of a broad spectrum of inflammatory proteins were performed and numbers of lamina propria macrophages were determined with semiquantitative morphometry".

And, "WD significantly alters the local colonic immune response. Collectively, these data suggest that consumption of a WD interferes with networks of related biological response pathways involving colonic lipid metabolism, oxidative stress, and the immune response".

The results strongly suggested that by maintaining the healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a potential and natural compound for the prevention and treatment diseases associated with oxidative stress, researchers examined the effect of conventional, organic, and mixed cultivation practices on the content of total phenolics, total flavonoids and antioxidant activity in two varieties of onion grown over 4 years in a split-plot factorial systems comparison trial.

According to the experiment, levels of total phenolics and total flavonoids were significantly different between organic and conventional production systems.

Levels of antioxidants such as levels of total phenolics, total flavonoids are significantly higher under fully organic growth compared to conventional growth.

In other words, if you are looking for the best onion with antioxidant activity, organic cultivation onion is a better choice

Based on the findings, researchers said, "organic cultivation practices resulted in significantly higher levels of potentially bioactive compounds in onion".

Taken altogether, onion may be considered a remedy for the prevention and treatment of diseases associated with oxidation, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
(2) Evaluation of polyphenolic content and antioxidant activity in two onion varieties grown under organic and conventional production systems by Ren F1,2, Reilly K1, Gaffney M1, Kerry JP2, Hossain M1, Rai DK. (PubMed)
(3) Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer by Ildiko Erdelyi,4 Natasha Levenkova,5 Elaine Y. Lin,8 John T. Pinto,9 Martin Lipkin,4Fred W. Quimby,6 and Peter R. Holt. (PMC)