Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 5 July 2019

Turmeric Protects the Neurons Against Amyloid Plaques that Cause the Onset of Alzheimer’s disease

By Kyle J. Norton

Amyloid plaques are the formation of beta-amyloid, which has been found to interfere or disrupt the information transmitted between nerve cells.

Beta-amyloid, the main component of the amyloid plaques found in the brain cells is a hallmark in patients with Alzheimer's disease.

Beta-amyloid formed part of the larger protein called “amyloid precursor protein” (APP) that extends from the inside of brain cells to the outside by passing through the fatty membrane around the cell.

According to the statistics, from Alzheimer’s Disease International, nearly 44 million people worldwide, are living with Alzheimer’s or related dementia.

Sadly, Alzheimer’s and dementia is most common in Western Europe and North America compared to other parts of the world.

A joint study led by the Woosuk University, Wanju suggested that-5 ethanol extract including turmeric may have a therapeutic effect in vitro and in vivo on Aβ-induced AD in mice.

Under normal conditions, APP bind to other proteins on the surface of cells to attach to one another, when they are cut by other proteins. In some circumstances, probably due to DNA alternation or genetic mutation, one of the pieces beta-amyloid is produced. The accumulation of beta-amyloid into microscopic amyloid plaques over time can cause gradual death of the affected brain cell, leading to to the onset of Alzheimer’s disease (AD).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

According to the study, WS-5 exerted a significant inhibitory effect on acetylcholinesterase (AChE). associated with reduced function of neurotransmitters.

Furthermore, WS-5 prevented Aβ oligomerization associated with neurodegeneration in Alzheimer's disease via inhibition of Aβ 1-42 aggregation.

Moreover, according to the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay, WS-5 possessed a high antioxidant activity, observed by the increase of the total antioxidant status (TAS).

Some researchers in the investigated the increased expression of amyloid plaques found in the aging population with AD wrote, "Age is the single greatest risk factor for Alzheimer’s disease with the incidence doubling every 5 years after age 65".

And, "a highly significant correlation between increasing age and slowed amyloid-beta turnover rates (2.5-fold longer half-life over five decades of age). In addition, we found independent effects on amyloid-beta42 kinetics specifically in participants with amyloid deposition. Amyloidosis was associated with a higher (>50%) irreversible loss of soluble amyloid-beta42 and a 10-fold higher amyloid-beta42 reversible exchange rate".

In other words, the genetic preposition that causes the onset of amyloid beta accumulation takes years to form amyloid plaques that destroy the brain neuron.

Additionally, WS-5 also protected the neuron against plaque formation by its anti-inflammatory properties observed by the inhibition of lipopolysaccharide-induced production of nitric oxide and two proinflammatory cytokines, TNF-α and IL-6, similarly to those in elderly AD.

More importantly, memory impairment in mice with Aβ-induced AD was also inhibited by the injection WS-5, according to the Morris water maze and passive avoidance test.

In other words, W-5 protected the neurons against the pathological changes in the hippocampus and cortex region of the mouse brain induced AD by lipopolysaccharide.

More importantly, WS-5 (250 mg/kg) treatment improved learning and suppressed memory impairment as well as reduced Aβ plaque accumulation in Aβ-induced AD.

Collectively, researchers wrote, "WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention of amyloid plaques induced neurodegenerative disorders, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer's Disease by Bukhari SN1, Jantan I. (PubMed)
(2) WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinaleContains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice by Kim JE1, Shrestha AC1, Kim HS1, Ham HN1, Kim JH1, Kim YJ1, Noh YJ1, Kim SJ1, Kim DK1, Jo HK2, Kim DS2, Moon KH3, Lee JH3, Jeong KO3, Leem JY. (PubMed)
(3) Age and Amyloid Effects on Human CNS Amyloid-Beta Kinetics by Bruce W. Patterson, PhD,1 Donald L. Elbert, PhD,2 Kwasi G. Mawuenyega, PhD,3 Tom Kasten, PhD,3 Vitaliy Ovod, MS,3 Shengmei Ma, MS,4 Chengjie Xiong, PhD,4,7 Robert Chott, BS,1Kevin Yarasheski, PhD,1 Wendy Sigurdson, RN, MSN,3,7 Lily Zhang, BS,8 Alison Goate, D. Phil,5,8 Tammie Benzinger, MD, PhD,6,7 John C. Morris, MD,3,7 David Holtzman, MD,3,7,8and Randall J. Bateman, MD. (PMC)

Phytochemical isobetanin Protects the Breast Cell integrity and Viability Against Breast Cancer

By Kyle J. Norton

The breast formed part of the women reproductive system is the tissue overlying the chest muscles with a primary function to produce milk for nutrition to the infant and baby.

The size of a women breast is totally depending on the amount of fat accumulation.

Breast cancer is a type of cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

However, at the advanced stage, invasive cancer cells can travel a distance away from the breast to infect other healthy tissue and organ via lymph and blood, leading to secondary metastasis.

According to the joint study led by the Unité Génie Enzymatique et Cellulaire, phytochemical isobetanin may process chemopreventive activity against breast cancer.

Isobetanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...

In MCF-7-treated cells, betanin/isobetanin concentrate exerted anti-cancer activity by significantly decreased cancer cell proliferation and viability.

Betanin/isobetanin concentrates increased the levels of proteins associated with the promotion of apoptosis such as Bad, and p53 and alternated the cancer cells mitochondrial membrane potential that processed energy storage during oxidative phosphorylation.

Betanin/isobetanin treatment also induced autophagic cell death in MCF-7 cancer cell line.

According to the statistics, the lifetime risk of breast cancer of a woman is 12%. In the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in women along with 62,930 new cases of non-invasive (in situ) breast cancer, compared to 2,670 new cases of invasive breast cancer in men in 2019.

Most common symptoms at the early stage of breast cancer are lump (mass) in the breast, in the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.

However, at the advanced stage, patients with breast cancer may also experience additional symptoms of bone pain (secondary tumors in the bone), shortness of breath (secondary tumors in the lung), unintentional weight loss and drop in appetite (secondary tumors in the liver) and headaches, neurological pain or weakness (secondary tumors in the nervous system).

The causes of breast cancer are unknown. Out of many risk factors associated with the risk of breast cancer, aging may be a major factor as most breast cancers are diagnosed after age 50.

Dr. Christopher C. Benz wrote, "early-onset breast cancers largely represent inherited or early life-transforming effects on the immature mammary epithelium, late-onset breast cancers likely follow extended exposures to promoting stimuli of susceptible epithelium that has failed to age normally"

And " late-onset breast cancers grow more slowly and are biologically less aggressive than early-onset breast cancers, even when controlled for hormone receptor (e.g. estrogen receptor, ER) and growth factor receptor (e.g. HER2) expression, supporting the conclusion that the biology of breast cancer is age-dependent".

More precisely, betanin/isobetanin inhibits breast cells toxicity induced breast cancer caused by accumulated of breast tissue damage due to oxidative stress over time.

Based on the finding, researchers said, "Our data bring new insight to consider the betanin/isobetanin mix as a therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors".

Taken altogether, isobetanin combined with betanin/may be considered a remedy for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Phytochemicals in quinoa and amaranth grains and their antioxidant, anti-inflammatory, and potential health beneficial effects: A review by Yao Tang and Rong Tsao (Reseach Gate)
(2) Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells by Nowacki L1,2, Vigneron P2, Rotellini L2, Cazzola H1, Merlier F1, Prost E1, Ralanairina R3, Gadonna JP3, Rossi C1, Vayssade M. (PubMed)
(3) Impact of aging on the biology of breast cancer by Christopher C. Benz. (PMC)

Phytochemicals Lycopene Inhibits Cancer Caused by NADPH Oxidase Induced Overexpression of Free Radicals

By Kyle J. Norton

NADPH oxidases, a multisubunit enzyme comprising membrane and cytosolic components plays a critical role to protect our body against pathogenic microorganism by maintaining the immune function, cell growth, and apoptosis.

NOX family of NADPH oxidases deficiency can cause immunosuppression, leading to the overexpression of intracellular ROS that results in various lethal diseases.

Epidemiologically, diseases associated with NOX family of NADPH oxidases deficiency induced immunosuppression are frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections, inflammation, and infection of internal organs, blood disorders, such as low platelet counts or anemia, digestive problems, such as cramping, loss of appetite, nausea and diarrhea and delayed growth and development, particularly in cancer developing.

The NOX family of NADPH oxidases overexpression caused by a defect of its different subunits produced high levels of ROS in the gastrointestinal tract that causes chronic inflammatory stress; cytokine induction, leading to the formation of digestive cancer such as colorectal cancer.

A recent joint study led by the National Cancer Institute suggested that lycopene may be used for the treatment of cancer that targets the expression of NADPH oxidase 4-5 (NOX4-5).

Cancer is a class of diseases caused by cell growth irregularly and uncontrollably due to the alternation of cell DNA. Over time, cancer cells induced tumor formation to become progressively worse, leading to secondary metastasis.

In patients with chronic pancreatitis, overexpression of free radical has been found to orchestrating pancreatic cancer.

Furthermore, NOX4 overexpression increased the pre-malignant fibrotic states that lead to carcinomas of the lung and liver.

High expression of NOX5 is also found in patients with malignant melanomas, prostate cancer, and Barrett's esophagus-associated adenocarcinomas,

NOX4 and 5 are members of the NOX family of NADPH oxidases.

Furthermore, lycopene administration in vitro and vivo significantly inhibited NOX4 protein expression at 2.5 μM, compared to other concentrations.

The efficacy of lycopene ameliorated the expression of NOX4 protein was attributed to the significant inhibition of the NOX4 mRNA expression associated with the function of NOX in the production of reactive oxygen species.

Dr. Roy K, the lead scientist in the investigation of the risk of cancer in the NOX family of NADPH oxidases wrote, "Over-expression of functional NOX proteins in many tissues helps to explain tissue injury and DNA damage from ROS that accompany pre-malignant conditions, as well as elucidating the potential mechanisms of NOX-related damage that contribute to both the initiation and the progression of a wide range of solid and hematopoietic malignancies".

In SK-Hep-1 cells, intracellular ROS levels were also decreased by the injection of lycopene.

Moreover, the levels of NOX4 protein expression, and NOX activity and the intracellular ROS associated with transforming growth factor β (TGF-β)-induced cancer cell metastasis also were eradicated by the activity of lycopene upon injection.

Other mechanisms such as proteins involved in anti-apoptosis and enhanced cancer cells migration, invasion, and adhesion were also inhibited by the expression of lycopene.

Taken altogether, lycopene may be considered a natural remedy for the prevention of cancer cell metastasis associated with the overexpression of NADPH oxidase, pending to the confirmation of larger sample size and multicenter studies.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Lycopene Inhibits Cholestasis in Pregnancy

By Kyle J. Norton

Cholestasis is a condition associated with an improper secretion of bile by the liver, leading to symptoms of yellowish skin and whites of the eyes, the skin itches, urine is dark urine, and stools with light-colored and smell foul.

Most common cholestasis are caused by the diseases or conditions associated with the liver, bile duct, and pancreas.

More precisely, liver diseases such as acute hepatitis, alcoholic liver disease, primary biliary cholangitis with inflammation and scarring of the bile ducts, cirrhosis due to viral hepatitis B or C are most common causes of cholestasis.

Epidemiologically, long-term use of conventional medicines such as amoxicillin/clavulanate, chlorpromazine, azathioprine is also found to induce the aforementioned condition.

In pregnancy, cholestasis has been found to increase symptoms of itchiness and the risk for fetal distress, preterm birth, or stillbirth.

The exact causes of cholestasis in pregnancy are unknown. However, most common risk factors associated with cholestasis pregnancy are personal or family history of cholestasis of pregnancy and history of liver damage.

Conventionally, treatment is depending on the severity of the symptoms induced by the conditions, including, ursodeoxycholic acid, to relieve itching and increase bile flow and menthol creams, to help soothe the itching.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound for the prevention of disease associated with liver oxidative stress, researchers examined the effects of lycopene on the pathogenesis of cholestasis.

Wistar albino rats.selected to the study randomized into 3 groups, including the sham group subjected to a sham operation, the BDL group subjected to bile duct ligation (BDL), and the BDL+L group subjected to BDL and treated with 10 mg/kg body weight of lycopene.

Based on the tested analysis, after 7 days of treatment, administration of lycopene showed a significant amelioration of the liver abnormal function parameters in BDL rats.

The efficacy of lycopene on treating the acute cholestasis involved in the reduction or stoppage of bile flow by the liver was attributed to significantly reduce the levels malondialdehyde, the liver oxidative stress markers, and nitric oxide associated with the overexpression free radicals.

Furthermore, lycopene also enhanced the levels of antioxidants produced by the host observed by the normalization of the levels of glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats.

According to the comet assay, lycopene also protected the cellular integrity against alternation of DNA in the lymphocytes and hepatocytes of the BDL rats.

Based on the findings, researchers wrote, "These results suggest that lycopene might have protective effects on acute cholestasis".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of acute cholestasis, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Phytochemical Alliin, the Potent Antioxidant

By Kyle J. Norton

Antioxidants are stable atoms produced by the host or from the dietary sources with a function that inhibit free radicals.

Free radicals are the unstable atoms with highly reactive nature and single electron on the outermost ring. Therefore, in order for them to become stable, free radicals are ready to intercept or donate an electron to other stable atoms, leading to a chain reaction that can not be stopped until all electrons on the outermost ring are paired or inhibited by antioxidants.

Oxidative stress is a condition associated with overexpression of free radicals compared to low levels of antioxidants in the body. Over time, oxidative can cause protein, lipid, and cellular damage, leading to cells injury and death that facilitate the onset of chronic diseases, including CVD and cancer.

Believe it or not, free radicals at a moderate level are necessary for the body function, including maintaining the heart in the regulation of relaxation and constriction. However, if levels of free radical presented with a large amount, they can cause heart disease.

Most common types of free radical include

* Hydroxyl radical (OH•)
The hydroxyl radical is the neutral form of the hydroxide ion (OH–) produced from the decomposition of hydroperoxides (ROOH) by the reaction of an elevation in energy level above an arbitrary baseline energy state molecular oxygen.

* Superoxide anion radical (O2–•)
A superoxide anion is a compound that possesses an atom or molecule in which the total number of electrons is not equal to the total number of protons, giving it a net positive or negative electrical charge with the chemical formula O2− with one unpaired electron, leading to the generating of superoxide anion free radical.

* Singlet oxygen
Singlet oxygen is the common name used for the diamagnetic form of molecular oxygen (O2), which is less stable than the normal triplet oxygen.

* Hydrogen peroxide
Hydrogen peroxide (H2O2) is the simplest peroxide, a clear liquid, slightly more viscous than water, that appears colorless in dilute solution. It is considered a highly reactive oxygen species because of its strong oxidizing capacity.

* Lipid peroxyl free radical
Lipid peroxidation is a process in which free radicals steal electrons from the lipids in cell membranes, most often affecting polyunsaturated fatty acids, that can lead to cell membrane damage.

* Nitric oxide
Nitric oxide is a chemical compound with chemical formula NO. Even though low levels of NO production are important in protecting the liver from ischemic damage and contributing to proper smooth muscle contraction and growth, but its free radical and toxic nature can cause DNA damage and inflammation.

* Alkoxyl radical
Alkoxyl radical which is an alkyl (carbon and hydrogen chain) group singular bonded to oxygen can result in cellular damage caused by oxyfluorfen, a herbicide.

*Peroxynitrite
Peroxynitrite is the anion with the formula ONOO−reacted quickly with carbon dioxide, leading to forming of carbonate and nitrogen dioxide radicals.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural ingredient for the treatment of diseases associated with oxidative stress, researchers investigation the alliin antioxidant effects.

By comparing four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers found that
* Alliin was the best free radical scavenged superoxide, compared to others phytochemicals.
* Allicin suppressed the formation of superoxide by inhibiting the xanthine/xanthine oxidase system associated with the generation of ROS.

* The antioxidant activity induced by alliin was probably associated with a thiol exchange mechanism, a chemical reaction in which a thiolate group −S− attacks a sulfur atom of a disulfide bond −S−S−.

* Hydroxyl radicals were also inhibited by alliin.

* However, alliin did prevent alliin, allicin microsomal lipid peroxidation.

Based on the findings, researchers wrote, "both alliin and allyl cysteine were hydroxyl scavengers, and allyl disulfide was a lipid peroxidation terminator"

In other words, alliin protects the body against the overexpression of free radicals in the induction of a chain reaction to cause lipid and cellular damage.

Dr, Chung LY again in the summary, said, " our findings indicated that allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage".

Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Turmeric Protects the Liver cells Damage Against the Risk of Liver Disease

By Kyle J. Norton

Liver formed part of the detoxed organs in the human body is the largest internal organ that filters the blood from the digestive tract, before passing them to the rest of the body.

The liver also plays an essential role to produce cholesterol to build a strong cell wall, produce steroid hormones and vitamin D and aid the digestive function in food absorption and detoxify toxic chemicals and metabolizes drugs.

Liver disease is a process of reduced function of the liver acutely or gradually.

Liver cancer is a chronic liver disease associated with irregular cell growth that starts in the cells on the surface of the liver inner lining tissue, before penetrating into deeper layers to form tumor through cell proliferation.

At the advanced stage, the cancerous cell in the primary liver cancer can travel a distance away to infect other nearby healthy tissue or organ, via blood and fluid circulation, leading to secondary metastasis.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some form of liver disease,

Believe it or not, 95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

Most common signs and symptoms of liver disease are jaundice, abdominal pain, and swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, or bloody or tar-colored stool and tendency to bruise easily.

If you have experienced some of the aforementioned symptoms that do not heal in a short period of time, please check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potent compound for the prevention of liver disease, researchers examined the liver protective effect of curcumin.

Curcumin showed a strong antioxidant activity that protects the liver against several mechanisms involved in hepatotoxicity, leading to cell membrane disruption, and initiation of the immune response.

Furthermore, the bioactive ingredient also improved the cellular pathways of drug metabolism and inhibited the accumulation of reactive oxygen species (ROS) that cause liver damage.

Lipid peroxidation that leads to cell death caused by overexpression of free radicals in facilitating the chain reaction has also blocked the presence of curcumin.

Moreover, in various protocols of hepatotoxicity such as acetaminophen, alcohol, lindane, carbon tetrachloride (CCL4), diethylnitrosamine and heavy metals induced hepatotoxicities, injection of curcumin also showed significant efficacy in protecting the liver against damage, observed by reduced liver stress markers.

These results strongly suggested that curcumin is strong anti-oxidant and anti-inflammatory effects and thus it possesses hepatoprotective properties.

Collectively, researchers wrote, "the hepatoprotective effects of curcumin with a focus on its mechanistic insights in various hepatotoxic protocols".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of liver disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Identification of a Quality Marker of Vinegar-Processed Curcuma Zedoaria on Oxidative Liver Injury by Cui H1, Zhang B2, Li G3, Li L4, Chen H5, Qi J6, Liu W7, Chen J8, Wang P9, Lei H. (PubMed)
(2) Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects by Khan H1, Ullah H2, Nabavi SM. (PubMed)

Collard Greens Improves the Build-up of Bone Density Against Osteoporosis

By Kyle J. Norton

Bone density is also known as bone mineral density associated with the amount of bone mineral in bone tissue. The concept of bone density has been used to measure the mass of mineral per volume of bone to identify people in the risk and onset of osteoporosis.

Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone, mostly in the women in the menopause and older adult, leading to symptoms of joint pain, tenderness, and lack of flexibility and stiffness.

Some osteoporotic patient may also experience symptoms of grating sensation and bone spurs.

Aging, genetic preposition, overweight, and obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease. However, occupation with the repetitive movements of the joint has been found to affect people in the industrial world.

Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. The weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.

According to the statistics, approximately, more than 200 million people are suffering from osteoporosis, including 44 million Americans with either osteoporosis or low bone mass and 1 in 3 women over the age of 50 years and 1 in 5 men will experience osteoporotic fractures in their lifetime.

Dr. Jakob F, the lead scientist in the study of the risk of osteoporosis in aging population wrote, "Age is a high-risk factor for osteoporosis. Vitamin D insufficiency and reduced calcium absorption are common in the elderly. Loss of bone and muscle development in a vicious circle of immobilization caused by underlying diseases. In addition deficits in cognition and coordination promote falls and fragility fractures".

And, "Specific medication is indicated if the 10-year fracture risk exceeds 30 %, wherein women > 75 and in men > 85 years of age bone density measurement can be relinquished".

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a natural compound for the treatment of osteoporosis, researchers examined the effects of sulforaphane (SFN) on age-related shifts in anabolic and catabolic responses.

According to the tested differentiation, in both normal and ovariectomized mice that treated with SFN for 5 weeks, sulforaphane (SFN), a naturally occurring in collard greens promotes osteoblast differentiation by epigenetic mechanisms associated with enhancing the production of bone density.

Furthermore, SFN enhanced active DNA demethylation via Tet1 and Tet2 involved in the production of bone cells against the pathogenesis of osteoporosis and promoted pre-osteoblast differentiation by enhancing extracellular matrix mineralization and the expression of osteoblastic markers in the process of making new bone cells.

Where Tet loss has been associated with abnormal osteoclast function.

Moreover, SFN inhibited the expression of the osteoclast activator RANKL in osteocytes associated with bone reabsorption and induced apoptosis in pre-osteoclastic cells through the several mechanisms involved in bone degenerative pathology.

The results suggested that these mechanistic effects not only lowers the rate of bone reabsorption but also accelerates the production of higher bone volume.

More importantly, SFN protected the bone density against the shifts in mineral density distribution observed by quantitative back-scattered electron imaging (qBEI).

Based on the findings, researchers concluded, "Our data indicate that the food-derived compound SFN epigenetically stimulates osteoblast activity and diminishes osteoclast bone resorption shifting the balance of bone homeostasis and favor bone acquisition and/or mitigation of bone resorption in vivo".

Taken altogether, collard green processed a higher amount of sulforaphane (SFN) may be considered supplements for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake sulforaphane (SFN) in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anabolic and anti-resorptive modulation of bone homeostasis by the epigenetic modulator sulforaphane, a naturally occurring isothiocyanate by Roman Thaler1,2, Antonio Maurizi3 , Paul Roschger1 , Ines Sturmlechner1 , Farzaneh Khani2 , Silvia Spitzer1 , Monika Rumpler1 , Jochen Zwerina1 , Heidrun Karlic1 , Amel Dudakovic2 , Klaus Klaushofer1 , Anna Teti3 , Nadia Rucci3*, Franz Varga1*, Andre J. van Wijnen by (JBC Paper in Press)
(2) [Age and osteoporosis. Effects of aging on osteoporosis, the diagnostics and therapy].[Article in German] by Jakob F1, Seefried L, Schwab M. (PubMed)