Antioxidants Alliin Inhibits Disease Associated with Chronic Inflammation

By Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the invasion of harmful stimuli and pathogens.

In the acute phase of infection, the immune first line of defense white blood cells, macrophages stimulates the production of proinflammatory cytokines with an aim to destroy all invaders which try to enter the body.

Most cases of acute infection are stopped at this phase and the wound is healed itself quickly.

However, if the wound is too large, then the recovery may take a longer period of time and through 4 overlap recovery stages.

Any interruption in the overlapped recover stage may cause the formation of scars, similar to those of overproduction of pro-inflammatory cytokines.

Diseases associated with chronic inflammation induced by protein, lipid and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.

In other words, prolonged low-grade inflammation caused by continuing the production of proinflammatory cytokines due to an immune response that can not kill off all invaders in a set period between 3-8 weeks can result in serious and chronic diseases.

The results have been found to cause cell death and alternation of cell DNA.

Believe it or not people with low-grade chronic inflammation are prone to psychological stress that links to greater risk for depression, heart disease. particularly the body ability to regulate the inflammatory response and normal defense.

Out of many risk factors involved the onset of chronic inflammatory diseases, some researchers suggested the promotion of a high-fat diet in the Western world may correlate to the rise of the condition.

Dr. Yehui Duan, the lead scientist wrote, "In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has been increasingly viewed as a significant modifiable risk factor for diseases such as diabetes and certain types of cancer".

And, "the recent scientific literature about HFD-induced inflammation and subsequent development of diseases and cancer, with an emphasis on mechanisms involved. Given the expanding global epidemic of excessive HFD intake, understanding the impacts of an HFD on these medical conditions, gaining great insights into possible underlying mechanisms, and developing effective therapeutic strategies are of great importance".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In the urgency to find a natural and potential compound for the treatment of diseases associated with inflammation, researchers examined the active component is alliin (S-allyl cysteine sulfoxide) anti-inflammatory activity.

Before incubated with alliin, lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes showed a significant increase in proteins involved in the production pro-inflammatory cytokines, including IL-6, MCP-1, and Egr-1 in 3T3-L1 adipocytes exposed to 100 ng/mL LPS for 1 hour.

According to the tested assay in lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes incubated for 24 h with 100 μmol/L alliin, the bioactive compound inhibited such increase.

 Furthermore, the overexpression of the phosphorylation of ERK1/2 associated with cell differentiation including cell death caused by LPS-induced inflammation in adipocytes was also decreased following alliin treatment.

Additionally, alliin prevented the expression of inflammation in facilitating the alternation of cell DNA by modulating the gene expressions involved in immune response such as tumor suppressive gene and inhibiting the genes related to cancer.

Dr. Saray Quintero-Fabián, the lead scientist wrote, " The present results have shown that alliin is able to suppress the LPS inflammatory signals by generating an anti-inflammatory gene expression profile and by modifying adipocyte metabolic profile".

Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases associated with inflammation, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes by Saray Quintero-Fabián,1,2 Daniel Ortuño-Sahagún,1 Manuel Vázquez-Carrera,3 and Rocío Ivette López-Roa. (Hindawi)
(2) Inflammatory Links Between High Fat Diets and Diseases by Yehui Duan,1,† Liming Zeng,2,† Changbing Zheng,3 Bo Song,3 Fengna Li,1 Xiangfeng Kong,1and Kang Xu. (PMC)

Phytochemical Betanin Modulates the Production of Reactive Oxidative Species (ROS)

By Kyle J. Norton

Reactive oxidative species or ROS are chemically reactive atoms containing oxygen

In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.

Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stable, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading a domino's effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.

Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid and cellular damage.

Believe it or not, free radical levels in a moderate amount are necessary to enhance the body functioning, including vascular relaxation.

By balancing the ratio of free radicals and antioxidant may be the best way to avoid the development of chronic illness associated with oxidative stress.

However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.

Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".

And, "Further, at adequate free-radical concentrations a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".

The result clearly suggested developing free-radical inhibitor may some days be used for the medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation and also aging. 

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot major components, on ROS production.

In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.

Furthermore, betanin did not affect the activity of caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.

In other words, betanin inhibited the free radical activity in the initiation of cytotoxicity through its antioxidant activity.

Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".

In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.

According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO, restored cellular GSH reservoirs.

Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues through stimulating the production of the antioxidant enzyme from the host.

Dr. Ahmadian E, the lead scientist wrote, "the potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".

Taken altogether, betanin may be considered supplements for the prevention of the overexpression ROS, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)

Healthy Food Turmeric Protects the Kidney Against Renal Dysfunction

By Kyle J. Norton

Renal protection is strategies that protect the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.

Kidneys, a pair of the bean-shaped organ in the human body only filters out blood but also balances the body fluids by eliminating them and remove them through urinary secretion.

Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness

In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.

The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.

Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are assymptomatic.

* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.

*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.

Most patients are assymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.

* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function

* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.

Where eGFR is short for estimated glomerular filtration rate.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential compound with the kidney protective effect against the side effects of Cisplatin, researchers investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage.

The study included selected rats treated by Tetrahydrocurcumin orally every day at a dose of 80 mg/kg body weight for ten days, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) in 0.9 % saline on day four.

According to the tested assays, Cisplatin-induced renal cell damage was significantly reduced by tetrahydrocurcumin treatment.

Tetrahydrocurcumin also suppressed the cisplatin-treated rat in inducing overexpression of the creatinine clearance levels, an indication of kidney dysfunction.

Proinflammatory protein associated with increased oxidative stress in the kidney caused by cancer medicine was also inhibited by tetrahydrocurcumin administration during the experiment.

After taking into account co and confounders, the researcher wrote, "collectively provide therapeutic evidence that tetrahydrocurcumin ameliorates renal damage by regulating inflammation and apoptosis".

In order to reveal more information about turmeric renal protective activity, researchers evaluated the intervening effects of Curcuma aromatica oil on renal interstitial fibrosis rats induced by unilateral ureteral obstruction.

The study included infected rats treated with Curcuma aromatica oil on 3, 7, 14, and 28 days.

According to the Nuclear magnetic resonance (NMR)-based metabonomics combined with clinical chemistry and histopathology examination, Curcuma aromatica oil demonstrated strong kidney protection by inhibiting some metabolic pathways associated with the onset of renal interstitial fibrosis, including lipids metabolism, glycolysis, and methylamine metabolism,

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the protection of kidneys, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of tetrahydrocurcumin against cisplatin-induced renal damage: in vitro and in vivo studies by Song KI1, Park JY2, Lee S3, Lee D2, Jang HJ4, Kim SN3, Ko H5, Kim HY6, Lee JW3, Hwang GS2, Kang KS2, Yamabe N. (PubMed)
(2) Serum metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats by Zhao L1, Zhang H1, Yang Y2, Zheng Y1, Dong M1, Wang Y1, Bai G3, Ye X3, Yan Z3, Gao H. (PubMed)

Cucurbitacin B (CuB) Isolated from Cucumbers (Cucumis sativus), a Natural Antiangiogenic and Antimetastatic Potential Bioactve Compound

By Kyle J. Norton

Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.

Anti-metastasis is an action in which substance or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor. 

Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered process antimetastatic activity.

In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation. 

Angiogenesis is the process by stimulating the growth of new blood vessels from preexisting blood vessels used by the tumor to obtain nutrient in facilitating cancer proliferation.

Anti-angiogenic activity is an action in which substances such as drugs and herbal medicine are used to stop tumors from growing their own blood vessels.

Conventionally, medicines that block the block vascular endothelial growth factor (VEGF) from attaching to the receptors on the cells that line the blood vessels. such as bevacizumab (Avastin). Bevacizumab is considered anti-angiogenic drugs.

Believe it or not, as of today, there is no anti-metastatic drug on the market,  even over 90 percent of cancer deaths today are due to metastasis formation. Dr. Stock AM, the lead scientist in the examined the targets for anti-metastatic drug development, wrote, "Tumor cell migration is the essential prerequisite for invasion and metastasis formation. It is regulated by signal substances in terms of the grade of activity and in terms of direction (chemotaxis)".

And, "Moreover we provide with the example of beta-blockers, how established drugs in other indications are possibly effective and can be co-opted as such anti-metastatics".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

Scientists in the urgency to find the natural compound for the treatment of cancer examined the effect of Cucurbitacin B (CuB), a plant triterpenoid found abundantly in cucumber against the metastatic and angiogenic potential of breast cancer cells.

During the experiment, CuB showed significant activity in the inhibition of cellular proliferation and induction of apoptosis in the tested cancer cells in a time- and dose-dependent manner.

Furthermore, at the sub-IC50 concentrations, injection of CuB inhibited the migratory and invasive potential of highly metastatic breast cancer MDA-MB-231 and 4T1 cells.

In HUVECs, administration of CubB also inhibited migratory, invasive and tube-forming capacities.

In chick embryo chorioallantoic membrane, CuB exerted a strong anti-angiogenic effect in the prevention of new blood vessels.

According to the tested assay, the efficacy of Cub antimetastatic and angiogenic properties was attributed to the blocking of the matrix and proteins (VEGF/FAK/MMP-9) in signaling the development of new blood vessels from the existing vessels to induce cancer cells proliferation.

Additionally, the anti-angiogenesis was also evidenced by the decreased protein CD31 associated with more than 90% of angiosarcomas.

Dr. Sinha S, the lead scientists said, "Collectively, our findings suggest that CuB inhibited breast cancer metastasis and angiogenesis, at least in part, through the downregulation of VEGF/FAK/MMP-9 signaling".

In non-small cell lung cancer (NSCLC) both in vitro and in vivo, at nanomolar concentrations injection of CuB demonstrated a strong anti-migratory and anti-invasive ability against metastatic NSCLC by blocking the migratory, invasive and tube-forming capacities.

The efficacy of the tested compound in this experiment inhibited metastasis and angiogenesis was attributable to the suppression of proteins (Wnt/β-catenin) associated with pass signals into a cell through cell surface receptors to induce cell proliferation and formation of new blood vessels.

Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis by Sinha S1, Khan S1, Shukla S1, Lakra AD1, Kumar S2, Das G3, Maurya R2, Meeran SM. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Targets for anti-metastatic drug development by Stock AM1, Troost G, Niggemann B, Zänker KS, Entschladen F. (PubMed)

Phytochemical Alliin Inhibits the Onset of High Blood Pressure

By Kyle J. Norton

High blood pressure, a condition characterized by elevated blood pressure in the arteries. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

In other words, the heart has to work harder to circulate blood to the body needs in high blood pressure patients. Long-term d elevate blood pressure raises the pressure of the heart, leading to damage to the heart tissue in facilitating the risk of cardiovascular disease.

According to the statistics provided by the CDC, approximately 54% of adults in the US are living with high blood pressure and half of that have an uncontrol condition.

Believe it or not, in the US, high blood pressure is a major cause of heart disease and stroke and a leading cause of death.

Many factors have been found to increase the risk of high blood pressure, including, tobacco or excessive alcohol drinking, chronic medical conditions such as kidney disease, diabetes and sleep apnea.

Some researchers suggested that the promotion of the Western diet with high consumption of salt may have a strong effect in increasing the prevalence of high blood pressure over the past few decades.

Dr. the lead scientist wrote, "Over the past century, salt has been the subject of intense scientific research related to blood pressure elevation and cardiovascular mortalities".

And, "The World Health Organization (WHO) strongly recommended reducing dietary salt intake as one of the top priority actions to tackle the global non-communicable disease crisis and has urged member nations to take action to reduce population-wide dietary salt intake to decrease the number of deaths from hypertension, cardiovascular disease, and stroke".

In other words, by following a healthy diet and moderate exercise, high blood pressure is preventable.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin)on blood pressure.

The study included rats fed either by a 2% high cholesterol diet with and without aqueous garlic powder extract given orally to rats on a daily basis for 6 weeks or control rats fed a normal diet.

Compared to elevated levels of cholesterol in the rat fed with cholesterol diet without garlic extract, rats fed with a high cholesterol diet mixed with garlic powder showed a significant reduction in their serum cholesterol levels.

The high blood pressure of rats induced by cholesterol diet was also inhibited by garlic powder.

In other words, the blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to other groups without affecting levels of glucose and protein.

Based on the results, researchers after taking other factors into account wrote, " garlic is beneficial in reducing...systolic blood pressure in hypercholesterolemic rats".

And, "Our experimental results show that garlic may beneficially affect two risk factors for... and hypertension".

Moreover, the Tel Aviv University study in the comparison of the effects of a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril and alliin and captopril suggested CPSSA in high dose significantly decreased blood pressure, triglycerides, and homocysteine concentrations compared to alliin with a slight effect on SBP and Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.

More precisely, Dr. Oron-Herman M, the lead scientist wrote, " the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".

Taken altogether, alliin may be considered supplements for the prevention and treatment of hypertension, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(3) Dietary Salt Intake and Hypertension by Sung Kyu Ha, M.D. (PMC)

Betacyanins, the Anti Liver Steatosis Phytochemical

By Kyle J. Norton

The liver is the largest internal organ that not only filters the blood coming from the intestinal system but also protects our body against chemical and drug toxicity.

Additionally, the liver also produces cholesterol that plays an essential role to aid digestion, produce vitamin D and steroid hormone and build strong cell membranes.

Believe it or not, the liver also produces antioxidant enzymes which inhibit free radical oxidation and interact with the hormone insulin to store glucose in the form of glycogen.

Hepatic steatosis is a condition caused by the accumulation of fat in the liver. Liver steatosis can be classified into 2 types

* Alcoholic liver steatosis is caused by over-consumption of alcohol over time.

* Non-Alcohol Steatosis (NASH) is a condition of accumulation of excess fat in the liver in people who drink little or no alcohol. ... Non-Alcohol Steatosis is considered a major cause of liver scarring and cirrhosis.

Most common symptoms of liver steatosis are jaundice, abdominal swelling (ascites), enlarged blood vessels just beneath the skin's surface, enlarged breasts in men, enlarged spleen and red palms.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

Conventionally, there is no effective treatment for liver steatosis. Weight loss and weight management through a combination of a healthy diet and exercise are the most recommendations.

Some researchers suggested that the rise of liver steatosis in the US may be correlated to the promotion of a high-fat diet over the past few decades.

Dr. Arisqueta L, the lead scientist wrote, "High-fat diet (HFD) feeding or leptin-deficient mice are extensively used as models resembling features of human nonalcoholic fatty liver disease (NAFLD)".

And, "The concurrence of experimental factors as fat content and source or total caloric intake leads to prominent differences in the development of the hepatic steatosis and related disturbances".

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment for the prevention and treatment of liver steatosis, researchers examined whether betanin (from natural pigments, a member of betacyanins) anti-oxidant properties against paraquat-induced liver injury in Sprague-Dawley rats.

Paraquat injected intraperitoneally into rats to induce liver toxicity randomly assigned to 4 groups: a control group, a paraquat group, and two groups received betanin at doses of 25 and 100mg/kg/day three days before and two days after administered paraquat.

Administration of betanin inhibited the elevated serum aspartate aminotransferase and alanine aminotransferase levels of the paraquat rats.

Betanin treated group also enhanced the production of antioxidant enzymes that counter the overexpression of free radicals induced oxidative stress.

Furthermore, betanin treated group also increased the expression of an enzyme associated with detoxification.

Moreover, liver mitochondrial damage caused by paraquat injection also was reduced by the administration of betanin.

In other words, all parameters associated with the onset of liver damage that causes steatosis developing were decreased substantially in the animals treated with betanin than in those who received paraquat alone.

Based on the results, researchers after taking other factors into account wrote, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".

Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Red pitaya betacyanins protect from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice by Song H1,2, Chu Q1, Yan F1, Yang Y1, Han W1, Zheng X. (PubMed)
(2) White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet-Induced Obese Mice by Song H1,2, Zheng Z1, Wu J1, Lai J1, Chu Q1, Zheng X. (PubMed)
(3) High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice by Arisqueta L1, Navarro-Imaz H2, Labiano I3, Rueda Y2, Fresnedo O. (PubMed)

Whole Food Tomato Balances the Ratio of Intestinal Microbiomes in the Gut

By Kyle J. Norton

Intestinal microbiome is the community of bacteria living in the gut. Under normal conditions, the ratio of good and bad microbiomes are balanced.

Believe it or not, our GI-tract harbors one of the most complex and abundant ecosystems colonized by more than 100 trillion microorganisms, including Firmicutes and Bacteroidetes.

The composition and functions of the microbiome also have been found to influence by a number of factors including genetics, diet, age,  and medical treatments such as antibiotics.

Epidemiological studies suggested that unbalanced of the ratio of bacterias in the GI tract due to the aforementioned factors also induce changes in microbiome structure, that links to inflammatory, functional and metabolic disorders such as IBD, IBS, and obesity. 

Dr. Ana M Valdes, the lead scientist in the examined the health benefits associated with intestinal microbiome suggested that gut microbes have a strong effect on human health including immune, metabolic and neurobehavioral traits.

More precisely, the intestinal microbiomes

* Interact with the immune function against inflammatory immune disorders.

* Reduce the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Increase nutrient absorption from the diet, thus reducing the risk of obesity and obese complications.

*  Control brain insulin signaling and metabolite levels against neurobehaviors.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to discover healthy food for the treatment of intestinal microbiome imbalance, researchers investigated the possibility of a dietary-induced switch to the gut microbiota composition.

The study included Winnie mice induced ulcerative colitis by treatment of chow enriched with 1% Bronze tomato.

According to the tested results, Bronze-enriched chow showed no macroscopic effect on the IBD symptoms after 2 weeks of administration. However, injection of bronze tomato exerted a significant effect in the production of anti-inflammatory cytokines and reduced levels of pro-inflammatory production in the same periods in ulcerative colitis mice.

Furthermore, the analysis of the microbial composition suggested that Bronze enriched diet demonstrated a strong effect on the microbial composition of Winnie and control mice by increasing levels of good bacteria in the gut.

According to the chemical analysis, the effect bronze tomato in improving the ratio of intestinal microbiome composition was attributed to the polyphenol-enriched diets in creating unfavorable conditions for bad bacterial species.

Another study conducted by the University of Arkansas at Little Rock to examined the effect of tomato fruits derived from plants exposed to multi-walled carbon nanotubes (CNTs) on gastrointestinal epithelial barrier integrity and their impact on the human commensal intestinal microbiota, in vitro cell culture and batch human fecal suspension models also suggested that

* At 0.001 μg ml-1 concentration, CNT-containing fruits showed insignificantly activity on the model T-84 human intestinal epithelial cells.

* However, at 10 μg ml-1 concentration, CNTs showed a strong effect in penetrating the cell membrane and change the gene expression profile of exposed tested cells.

Taken altogether, tomato processed multi-walled carbon nanotubes (CNTs) may be considered a dietary supplements for balancing the ratio of intestinal microbiota, pending to large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions by Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(2) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)