Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday, 16 June 2019

Whole Food Tomato Balances the Ratio of Intestinal Microbiomes in the Gut

By Kyle J. Norton

Intestinal microbiome is the community of bacteria living in the gut. Under normal conditions, the ratio of good and bad microbiomes are balanced.

Believe it or not, our GI-tract harbors one of the most complex and abundant ecosystems colonized by more than 100 trillion microorganisms, including Firmicutes and Bacteroidetes.

The composition and functions of the microbiome also have been found to influence by a number of factors including genetics, diet, age, and medical treatments such as antibiotics.

Epidemiological studies suggested that unbalanced of the ratio of bacterias in the GI tract due to the aforementioned factors also induce changes in microbiome structure, that links to inflammatory, functional and metabolic disorders such as IBD, IBS, and obesity.

Dr. Ana M Valdes, the lead scientist in the examined the health benefits associated with intestinal microbiome suggested that gut microbes have a strong effect on human health including immune, metabolic and neurobehavioral traits.

More precisely, the intestinal microbiomes

* Interact with the immune function against inflammatory immune disorders.

* Reduce the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Increase nutrient absorption from the diet, thus reducing the risk of obesity and obese complications.

* Control brain insulin signaling and metabolite levels against neurobehaviors.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to discover healthy food for the treatment of intestinal microbiome imbalance, researchers investigated the possibility of a dietary-induced switch to the gut microbiota composition.

The study included Winnie mice induced ulcerative colitis by treatment of chow enriched with 1% Bronze tomato.

According to the tested results, Bronze-enriched chow showed no macroscopic effect on the IBD symptoms after 2 weeks of administration. However, injection of bronze tomato exerted a significant effect in the production of anti-inflammatory cytokines and reduced levels of pro-inflammatory production in the same periods in ulcerative colitis mice.

Furthermore, the analysis of the microbial composition suggested that Bronze enriched diet demonstrated a strong effect on the microbial composition of Winnie and control mice by increasing levels of good bacteria in the gut.

According to the chemical analysis, the effect bronze tomato in improving the ratio of intestinal microbiome composition was attributed to the polyphenol-enriched diets in creating unfavorable conditions for bad bacterial species.

Another study conducted by the University of Arkansas at Little Rock to examined the effect of tomato fruits derived from plants exposed to multi-walled carbon nanotubes (CNTs) on gastrointestinal epithelial barrier integrity and their impact on the human commensal intestinal microbiota, in vitro cell culture and batch human fecal suspension models also suggested that

* At 0.001 μg ml-1 concentration, CNT-containing fruits showed insignificantly activity on the model T-84 human intestinal epithelial cells.

* However, at 10 μg ml-1 concentration, CNTs showed a strong effect in penetrating the cell membrane and change the gene expression profile of exposed tested cells.

Taken altogether, tomato processed multi-walled carbon nanotubes (CNTs) may be considered a dietary supplements for balancing the ratio of intestinal microbiota, pending to large sample size and multicenter human study.

Sources
(1) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions by Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(2) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)

Turmeric Protects Diabetics Against Renal Inflammation that Causes Diabetic Nephropathy (Dn)

By Kyle J. Norton

Diabetic renal inflammation is a condition associated with inflammation in the development of diabetic nephropathy.

Diabetic nephropathy (Dn) is a chronic kidney disease in diabetics, a leading cause of end-stage renal failure.

Epidemiologically, diabetic nephropathy is also associated with cardiovascular disease and increases mortality of diabetic patients.

Metabolic and hemodynamic alterations, oxidative stress, and activation of the renin-angiotensin system are some of the risk factors that have been found in patients with Dn.

Inflammation is a natural defense of the immune system that protects the body against the insult from the foreign invasion.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damage tissues are healed itself after all pathogens are killed off.

However, if the immune system can not completely destroy all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

In diabetes, the presence of chronic low-grade inflammation activated by the innate immune system induced production of pro-Inflammatory cytokines, mainly IL-1, IL-6, and IL-18, as well as TNF-α, are some of the major factors that involved in the development and progression of diabetic nephropathy.

Dr. Juan F. Navarro-González, the lead scientist in the examined the effect of inflammatory cytokines in the risk of Dn wrote, "When considering the role of cytokines in pathophysiological processes underlying disease, it is necessary to take into account the fact that the activities of these molecules are very complex, as reflected by important features, including their pleiotropic actions—and thus a cytokine may trigger several different cellular responses depending on diverse factors, such as cell type, timing, and context".

And, "Cytokines share receptor subunits; act synergistically in many contexts, and, therefore, the association of two cytokines can markedly amplify their effects; cytokines stimulate the cells that produce them, or adjacent cells, or even can intervene through direct cell-cell interaction; and, finally, cytokines induce the expression of other cytokines and cytokine receptors".

In other words, diabetic renal inflammation is the main culprit that causes the development of Dn.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential compound for the treatment of renal inflammation, researchers examined the effect of Curcumolide, a novel sesquiterpenoid isolated from Curcuma wenyujin for the control of diabetic retinopathy.

According to the experiment results, treatment with curcumolide alleviated retinal inflammatory activities both in vitro and in vivo in an STZ-induced diabetic rat model and in TNF-α-stimulated HUVECs.

Furthermore, curcumolide alleviated retinal vascular permeability by blocking the quality of a material or membrane that causes it to allow liquids or gases to pass through it, and leukostasis that causes elevated blast cell count and symptoms of decreased tissue perfusion in the retinas.

Moreover, curcumolide attenuated the overexpression of TNF-α and ICAM-1associaed with the production of pro-inflammatory cytokines in diabetic retinas through activation of NF-κB is a protein complex and p38 MAPK.

Based on the findings, researchers wrote, "These data suggest potential treatment strategies against diabetic retinopathy, particularly in the early stages of the disease".

Taken altogether, turmeric processed abundantly bioactive compound curcumolide may be considered supplements for the prevention and treatment of renal inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling by Cai Y1, Li W1, Tu H1, Chen N1, Zhong Z1, Yan P1, Dong J. (PubMed)
(2) The Role of Inflammatory Cytokines in Diabetic Nephropathy by Juan F. Navarro-González and Carmen Mora-Fernández. (JASN)

Saturday, 15 June 2019

Bromelain Protects the Cardiac Muscle in Blood Circulation

By Kyle J. Norton

Cardiac muscle or heart muscle or myocardium is a type of muscle that helps the heart to pump blood to nourish the entire body by performing the coordinated contractions.

Damage of heart muscle can lead to cardiomyopathy, or heart muscle disease, leading to abnormally heart enlarged, thickened, and/or stiffened.

In other words, cardiomyopathy reduced the heart muscle ability to pump blood, causing heart failure and the backup of blood into the lungs or the rest of the body.

Most common types of cardiomyopathy are

* Dilated cardiomyopathy is a condition caused by the enlarged and weakened the left ventricle.

* Hypertrophic cardiomyopathy is a result of the thickening of the heart muscle, at the septum between the ventricles, below the aortic valve.

* Ischemic cardiomyopathy is the condition caused by narrow arteries that affect the supply blood to the heart muscle.

* Restrictive cardiomyopathy is a condition that the walls of the lower chambers of the ventricles are too rigid to expand

Most common symptoms of cardiomyopathy are associated with reduce blood flow due to reduced function of heart muscle including general weakness and fatigue, shortness of breath, particularly during exertion or exercise, lightheadedness, and dizziness, chest pain, heart palpitations, fainting attacks, high blood pressure, edema, or swelling, of your feet, ankles, and legs.

If you have experienced some of the aforementioned symptoms, please check with your doctor to rule out the possibility of cardiomyopathy.

Out of many factors associated with the risk of cardiomyopathy, some researchers suggested that long-term alcoholism may be the major culprit.

Dr. B. Maisch wrote, " Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke".

However, "More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites".

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential ingredient for the improvement of cardiovascular circulation, researchers examined the effect of bromelain on ischemia/reperfusion (IR) injury is characterized by the production of oxygen-free radicals leading to disturbances in vasomotility (microvascular constriction) and microvascular permeability (interstitial edema formation).

The study included a rabbit hindlimb model of I/R (2.5/2 h) were given Phlogenzym, containing rutin, trypsin, and bromelain enterally (60 mg/kg body weight) 30 min prior to ischemia (Ph group).

Before treatment with Phlogenzym, two hours after reperfusion, potassium levels were significantly elevated in IR compared to the Ph group.

Application of Phlogenzym inhibited the enhanced lipid peroxidation, apparent by increased plasma malondialdehyde levels in the Ph group, particularly, in the reduction of blood flow.

Furthermore, Phlogenzym treatment also prevented microvascular constriction and mollified interstitial edema

In other words, Phlogenzym protects the cardiac muscle in blood circulation against damage caused by ischemia/reperfusion (I/R) injury.

Based on the findings, researchers wrote, "Phlogenzym had a protective effect on skeletal muscle during I/R injury expressed by prevention of no-reflow and preservation of muscle tissue".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the protection of heart muscle, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
Bromelain Osteoarthritis
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) The result of dosage and individual predisposition. Alcoholic cardiomyopathy by B. Maisch. (PMC)

Healthy Food Navy Bean Promotes Colon Health through Modulating Microbiome Metabolism

By Kyle J. Norton

The colon formed part of the digestive system plays a critical role to absorb water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colon health is the process to enhance the function of the colon through many mechanisms, particularly, in the improvement of the ratio of gut microbiota.

Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.

Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.

In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.

The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.

Epidemiological studies suggested overweight and obese people show a dysbiosis characterized by a lower diversity. Imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.

Some researchers suggested that we can optimize our colon health by manipulating the gut microbiota through diet by increasing the intake fiber, prebiotic and probiotic foods.

Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".

And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

On finding a natural compound for the improvement of colon health, researchers evaluated the effect of navy beans in the modulation of the host microbiome metabolism.

The 4-week, randomized-controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily, containing 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18).

According to the assessment of the impact on the human stool metabolome, which includes the presence of navy bean metabolites,

* 26 significantly different metabolites were found at day 28 in navy bean group compared to the participants' baseline (p ≤ 0.05) and to the control group.

* Additionally, of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites identified in the stool of participants consuming navy beans.

* Most importantly, the stool relative abundance of ophthalmic increased 5.25-fold for navy bean consumers strongly suggested that navy bean in the glutathione regulation and cancer control were attributed to detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis.

More precisely, navy-bean protects the colon cells integrity by exciting detoxed, antioxidant, anti-proliferation, and anti-apoptotic activity.

Based on the findings, researchers said, "These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merits further investigation for improving colonic health after long-term consumption".

Taken altogether, navy-bean may be considered a remedy for the improvement of colon health, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen. (PMC)

Healthy Food Onion Protect the Liver cells Against Alcoholic Cytotoxicity

By Kyle J. Norton

The liver is the largest organ in the human body that not only filters out blood coming from the digestive system but also secretes bile to aid digestion, produce vitamin D and steroid hormone and build strong cell walls.

The liver also detoxes the drug and environmental toxicity before they can cause damage to the human body.

Alcoholic cytotoxicity is a condition that excessive alcohol that induces healthy cell DNA alteration or cell death.

Excessive alcohol drinking epidemiologically is a major cause of alcoholic liver disease. Over time, the formation of liver scars not only promote the onset of cirrhosis also enhances the risk of liver cancer.

Some researchers suggested, there is a possible link associated with cytotoxicity of ethanol on the cells lining the tissues in direct contact with alcoholic beverages that solves the initiation of local carcinogenesis.

According to the recent study posted on the PubMed, short-term exposures (2-3 s) to ethanol concentrations between 10% and 15% have facilitated the cytotoxic effect on human epithelial keratinocytes in a concentration-dependent manner.

In other words, long-term injection of alcoholic beverages containing cytotoxic concentrations of ethanol, or diluting ethanol to cytotoxic concentrations can increase the risk of cancer, particularly to those of oral cavity, pharynx, larynx, and esophagus.

Diseases associated with alcoholic cytotoxicity are preventable by changing the way of drinking and replace alcoholic beverages containing non-cytotoxic concentrations of ethanol or diluting ethanol to non-cytotoxic concentrations.

Dr. Guillén-Mancina E in the evaluation of the cytotoxic concentrations of ethanol in the risk of cancer wrote, "Alcohol consumption is a known risk factor for cancer. Almost 6% of all cancers worldwide are attributable to alcohol use. Approximately half of them occur in tissues highly exposed to ethanol, such as the oral cavity, pharynx, upper larynx and esophagus".

And "However, since ethanol is not mutagenic and the mutagenic metabolite of ethanol (acetaldehyde) is mainly produced in the liver".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of liver cancer, researchers examined the effects of 3,4-dihydroxyphenylacetic acid (DOPAC), one of the major colonic microflora-produced catabolites of quercetin glycosides derived from the onion.

In murine hepatoma Hepa1c1c7 cells used in the study of the regulation of chemoprotective enzymes, administration of DOPAC exerted a significant activity in the modulation of the aldehyde dehydrogenase (ALDH) catalyzed oxidation.

Furthermore, the cytotoxicity induced by the acetaldehyde-induced cytotoxicity in vitro also was inhibited by the expression of DOPAC.

Moreover, in the modulation of the activity of the enzyme ALDH, DOPAC also enhanced the gene expression of ALDH1A1, ALDH2, and ALDH3A1 in a concentration-dependent manner.

In other words, the DOPAC protects the Hepa1c1c7 cells against alcohol-induced oxidative stress in the induction cytotoxicity that has been found to cause protein, lipid and cell damage.

The results strongly suggested that DOPAC isolated from onion inhibited the expression of alcoholic influence that leads to the damage of normal liver cells.

Based on the findings, researchers said, "DOPAC acts as a potential ALDH inducer to prevent the alcohol-induced abnormal reaction".

Taken altogether, onion may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) 3,4-Dihydroxyphenylacetic acid is a potential aldehyde dehydrogenase inducer in murine hepatoma Hepa1c1c7 cells by Liu Y1,2, Kurita A1, Nakashima S1, Zhu B2, Munemasa S1, Nakamura T1, Murata Y1, Nakamura Y. (PubMed)
(2) Avoiding the ingestion of cytotoxic concentrations of ethanol may reduce the risk of cancer associated with alcohol consumption by Guillén-Mancina E1, Calderón-Montaño JM1, López-Lázaro M. (PubMed)

Turmeric Inhibits the Infectious Disease Caused by Respiratory Syncytial Virus (RSV)

By Kyle J. Norton

Infectious diseases are disorders induced by organisms, including bacteria, viruses, fungi or parasites.

Out of trillions organism present on the earth, only a few hundreds have been known to cause diseases.

Most infectious diseases are passed from person to person through direct or indirect contact with the infected patient. Others can be transmitted by insects or animals.

However, infectious disease, the most prevalence in the third world countries are acquired by ingesting contaminated food or water.

Infectious diseases share the common symptoms of fever, diarrhea, muscle aches, coughing, fatigue similar to those of influenza. Other symptoms are totally depending on the types of organisms including bacteria, and virus.

In conventional medicine, except for viral infection, organisms induced infection can be treated with

antibiotics. If you are taking antibiotics for the treatment of chronic infection, please make sure that you know all the side effects for preventive measure.

Believe it or not, most cases of the infectious disease were stopped in the acute phase of infection. In which the immune system activated the first line of defense by destroying the pathogen before they have the chance of multiplication.

However, people with a weakened immune system such as the elderly and immature immune system such as the infants are prone to infectious disease.

Dr. Mouton CP, the lead scientist in the analysis of the immune system and disease associated with infection in the elderly wrote, "Infectious diseases account for one-third of all deaths in people 65 years and older... A change in mental status or decline in function may be the only presenting problem in an older patient with an infection. An estimated 90 percent of deaths resulting from pneumonia occur in people 65 years and older" and "Mortality resulting from influenza also occurs primarily in the elderly".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

In the urgency to discover a natural antiviral infection for the treatment of infectious diseases, researchers examined the effect of β-cyclodextrin (CD) functionalized graphene oxide (GO) composite, against the respiratory syncytial virus (RSV), which is considered as the major viral pathogen of the lower respiratory tract of infants.

According to the results from the tissue culture infectious dose assay and immunofluorescence assay, curcumin loaded functional GO exerted a significant activity in the inhibition for RSV infection.

Furthermore, curcumin loaded functional GO improved greatly the biocompatibility to the host cells.

In other words, the composite inhibited the infection caused by the respiratory syncytial virus (RSV) without causing harm to the healthy cell in the tested cells.

Dr. the leads scientist after taking into account co and confounders wrote, "the composite could prevent RSV from infecting the host cells by directly inactivating the virus and inhibiting the viral attachment, and possessed prophylactic and therapeutic effects towards the virus.

Taken altogether, turmeric may be considered a supplement for the prevention and combined with chemical compound for the treatment of viral infection, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin as an Adjunct Drug for Infectious Diseases by Padmanaban G1, Rangarajan PN. (PubMed)
(2) Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection by Yang XX1, Li CM, Li YF, Wang J, Huang CZ. (PubMed)
(3) Common infections in older adults by Mouton CP1, Bazaldua OV, Pierce B, Espino DV. (PubMed)

Friday, 14 June 2019

Bilberry Protects the Arteries Against the Risk of Atherosclerosis in Vivo

By Kyle J. Norton

Atherosclerosis, one of the major cause of the cardiovascular disease is a medical condition caused by the accumulation of plaque on the arterial wall. Over time, the condition can lead to narrowing the arteries or blocked arteries, leading to reduce oxygenated blood flow to the heart and other parts of the body.

Arteries are blood vessels carried the oxygen-rich blood to the heart before passing them to the tissues and organs.

Plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact to induce plaque accumulation.

People at the early stage of atherosclerosis are asymptomatic. However, over time, the continued buildup of plaque on the arterial wall can cause symptoms of chest pain or angina shortness of breath. fatigue. confusion, due to a blockage or reduce blood flow.

Although there are many risk factors associated with the onset of atherosclerosis, an unhealthy lifestyle, particularly in people who follow the pattern of the Western diet has been found in many patients with the disease.

Dr. Matthias Nahrendorf, the lead scientist wrote, "Diet, exercise, stress, and sleep are receiving attention as environmental modifiers of chronic inflammatory diseases, including atherosclerosis, the culprit condition of myocardial infarction and stroke".

And, "Accumulating data indicate that psychosocial stress and a high-fat, high-cholesterol diet aggravate the cardiovascular disease, whereas regular physical activity and healthy sleeping habits help prevent it".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

On finding a potential compound for the treatment of atherosclerosis researchers evaluated a nutritional supplementation with a bilberry anthocyanin-rich extract (BE) in the atherosclerotic lesion development in apolipoprotein E-deficient (apoE⁻/⁻) mice.

On the early stage of atherosclerosis development in tested mice, BE significantly improved hypercholesterolemia associated with plaques built-up without affecting the plasmatic antioxidant status.

According to the nutrigenomic analysis, BE modulated the expression of the gene involved in different cellular processes such as oxidative stress, inflammation, transendothelial migration, and angiogenesis, that lead to atherosclerosis development/protection.

In other words, BE enhanced the mechanisms involved in the preventive action of bilberry anthocyanin-rich extract against atherosclerosis.

On the development of atherosclerosis in apolipoprotein E-deficient mice (apo E(-/-)). Apo E(-/-) mice, researchers compared the efficacy of two bilberry extracts, one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE).

According to the 16 weeks a diet supplemented with 0.02% of either BE or FBE, both bilberry extracts led to significant inhibition of plaque development, without affecting the levels of oxidative stress parameters or lipid profiles.

These results strongly suggested that bilberry extract inhibited plaque development through other unknown mechanisms.

By comparative tests, fermentation generates new bioactive compounds FBE are more effective in attenuating progression of the atherosclerotic lesions compared to those of BE.

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of atherosclerosis, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice by Mauray A1, Felgines C, Morand C, Mazur A, Scalbert A, Milenkovic D. (PubMed)
(2) Atheroprotective effects of bilberry extracts in apo E-deficient mice by Mauray A1, Milenkovic D, Besson C, Caccia N, Morand C, Michel F, Mazur A, Scalbert A, Felgines C. (PubMed)
(3) Lifestyle effects on hematopoiesis and atherosclerosis by Matthias Nahrendorf and Filip K. Swirski. (PMC)