Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 13 June 2019

Healthy Legume, Navy Bean Reduces Risk of Breast Cancer

By Kyle J. Norton

The breast is the tissue overlying the chest muscles. in women, breasts are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of the women breast is totally determined by the amount of fat.

Breast cancer is a medical condition associated with alternation of cell DNA located either in the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Most cases of breast cancer start in the cells on the surface of the inner lining tissues of the breast before penetrating into deeper layers to form a tumor through cell cycle division.

According to the statistics provided by the American Cancer Society, in the U.S. approximately, 1 in 8 U.S. women (about 12%) will develop invasive breast cancer over the course of her lifetime.

In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

Most common symptoms of the early stage of breast cancer are lump (mass) in the breast, a lump in the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.

If you experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

The 5 years survival rate of breast cancer diagnosed at the early stage is closed to 100%.

At the advanced stage, patients may also experience additional symptoms of bone pain (Secondary tumors in the bone), shortness of breath (Secondary tumors in the lung), unintentional weight loss and drop in appetite (Secondary tumors in the liver) and headaches, neurological pain or weakness (Secondary tumors in the nervous system).

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

On finding a potential compound for the treatment of breast cancer, researchers evaluated the high dietary fiber intake and breast cancer risk, particularly in hormone receptor‐negative breast cancer.

According to the returned food frequency data of a population‐based case–control study, including 2135 breast cancer cases (1070 Hispanics, 493 African Americans, and 572 non‐Hispanic Whites (NHWs)) and 2571 controls (1391 Hispanics, 557 African Americans, and 623 NHWs), high intake of bean fiber and total bean, including the navy bean reduced risk of breast cancer by 20% compared to those in the low quartile.

Furthermore, high intake of bean fiber and total bean have a strong inverse association with ER‐PR‐ breast cancer. More precisely, the reduced risk of ER-PR breast cancer associated with high intake were ranging from 28 to 36%.

Believe it or not, fiber intake from vegetables and fruits or total intake of vegetables and fruits showed no effects on the reduced risk of the diseases.

In other words, adding a portion or 2 of the navy bean into your daily diet may have a significant effect in the prevention of breast cancer, particularly in hormone-related breast cancer

Based on the finding, researchers wrote in the final report, "A high dietary intake of bean fiber and fiber‐rich foods such as beans and grains may lower the risk of ER‐PR‐ breast cancer, an aggressive breast cancer subtype for which few risk factors have been identified".

Taken altogether, navy bean containing a high amount of fibers may be considered a remedy for the prevention and treatment of hormone-related breast cancer pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Intake of bean fiber, beans, and grains and reduced risk of hormone receptor‐negative breast cancer: the San Francisco Bay Area Breast Cancer Study by Meera Sangaramoorthy, 1 Jocelyn Koo, 1 and Esther M. John. (PMC)
(2) Breast Cancer by Kyle J. Norton

Wednesday, 12 June 2019

Phytochemical Alliin Protects the Liver Cell Integrity and Viability Against Liver Cancer

By Kyle J. Norton

The liver is the largest detoxed internal organ with a function to filter out blood coming from the intestines before passing them to other parts of the body,

Additionally, the liver also produces cholesterol to aid digestion, production of steroid hormones, vitamin D and building strong cell membranes.

Liver cancer is a chronic condition caused by irregular cell growth due to the alternation of liver cell DNA.

Compared to normal liver cells growth which is stopped after a certain stage of division, liver cancer cells can grow indefinitely to form a tumor, leading to reduced function of the liver.

According to the statistics provided by the American Cancer Society, in 2019, about 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed.

Primary liver cancer and intrahepatic bile duct cancer also cause the death of 31,780 people (21,600 men and 10,180 women) in 2019.

In the Western world, non-alcoholic fatty liver disease(NAFLD), a spectrum of hepatic disorders induced by obesity and metabolic syndrome, is a recognized risk factor for liver cancer.

Dr. György Baffy at the Harvard Medical School wrote, "Hepatocellular cancer (HCC) is the fifth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Non-alcoholic fatty liver disease (NAFLD), a spectrum of hepatic disorders associated with obesity and metabolic syndrome, is a recognized risk factor for HCC".

And, "NAFLD that is advanced to cirrhosis carries the highest risk for HCC, but there is an increasing concern that NAFLD-associated HCC may also occur in the non-cirrhotic liver".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential compound for the treatment of liver cancer, researchers examined the bioactive compound alliin isolated from garlic in an animal model, against liver cell DNA damage.

The study included rats induced liver cancer by N-nitrosodimethylamine (NDMA) were treated by administration of garlic powders for 2 weeks (5% of the diet).

According to the liver comet assay, injection of different garlic powders demonstrated a significant liver protective effect by a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.

Additional injection of alliin content of the garlic powder showed a strongly proportional decrease in NDMA induced DNA alteration.

Three garlic powders with or without alliin also protected the liver cell against DNA damage induced by aflatoxin B1 in the liver.

However, these decreases were not correlated to the allicin content of the garlic powders.

In other words, additional alliin increased the garlic powder function in the inhibition of liver cancer initiation caused by NDMA while alliin found in the garlic must work with other compounds synergically to induce the same effects.

Taken altogether, alliin may be considered supplements for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention by György Baffy. (PMC)

Cucumber Extract, A Natural Prevention and Treatment of Osteoarthritis

By Kyle J. Norton

Osteoarthritis (OA) is an inflammatory disease mostly caused by work-related occupations and working environment, affecting the muscles, joints, tendons, ligaments, and nerves, over time.

The disease is most prevalent in the US. Approximately 10% in men and 13% in women over the age of 60 years suffer from the condition.

In general population, OA affecting over 25 million people in the United States alone.

And, the numbers are increasing at an alarming rate due to the aging of the population and the obesity epidemic.

Most common symptoms of OA include pain in the joint(s), reduced movement of the joint(s), joint(s) tenderness and stiffness, particularly, the loss of flexibility and bone spurs.

If you have experienced some of the symptoms that do not get better in a short period of time, you may have OA.

Believe it or not, patients with OA are associated with the complications of a rapid, complete breakdown of cartilage, bone death (osteonecrosis) and stress fractures.

As of today, there is no cure for the condition, Treatment of OA conventionally are focusing on reducing the pain and progression of the disease and improving quality of life.

If you are taking medication for the treatment of OA, please make sure that you know all the side effects
Prolonged use of Acetaminophen has been found to cause liver damage.

In the prevention and management of OA, some researchers suggested

* Prevented recurrent injury to damage menisci
The meniscus is an important issue because if its function in shock absorption and load distribution in the healthy knee joint(111). A meniscal tear can lead to knee osteoarthritis (OA), but knee OA can also lead to a spontaneous breakdown of meniscal tear and damage to meniscal structure(112). Meniscus damage or recurrent injury might be considered as a signifying feature of incipient OA in middle-aged and elderly people(113).

*. Take precaution if your occupation is at increased risk of osteoarthritis
Osteoarthritis (OA) is one of the most important diseases as it frequently affects the active age group of the population contributed to the loss of working hours and of disability(114)(115)(117). Compressive, torsional, pulling and angular movements common in certain occupations or sports may result in injuries of soft tissue, thus increasing the development of OA(116).

* Muscle strengthening and aerobic exercises
Enhanced muscle strengthening with neuromuscular electrical stimulation(118), aerobic exercises(119) and exercise(220) are effective in reducing pain and improving physical function in patients with mild to moderate OA of the knee(220).

* Maintain a healthy weight(117)
Increased BMI and obesity are associated with more severe cartilage degeneration(121)(123) as assessed by both morphological and quantitative MRI measurements(122).

*Avoid dehydration
Dehydration has shown to reduce the mobility of collagen amino acid residues and carbon sugar ring structures in glycosaminoglycans, according to University of Michigan(124) of that may affect the functions of cartilage and induce the risk of OA(125), but dehydration effects are reversible, through the restoration of molecular structure and mobility(124).

* Avoid intake of inflammatory foods
Loading up on junk foods and fast foods contains a high amount of trans fat of that increases the risk of inflammation(126) exhibit pro-inflammatory effects(127) causes of osteoarthritis (OA)(128). Red meat, eggs, and wheat products all contain a high amount of arachidonic acid, too much arachidonic acid may be worsen the inflammation process(129), etc.

* Eat your fruits and vegetables
Fruits and vegetables containing high amount of nutrients and antioxidant(130), can enhance immune defense system(131)within the joint through direct influences of transferrin performance for reduction of inflammation(131)(132) as well as suppressing free radicals and the chain of free radicals reaction cause of elevating the swelling and promoting degeneration(133)(134).

* Replace regular beverage with green tea
Epigallocatechin-3-gallate, a green tea polyphenol(135)(136), was found to be effective in reducing inflammatory cytokines induced inflammatory diseases(137)(138).

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural compound for the treatment of osteoarthritis (OA), age-related disease researchers compared the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber; CSE) against GC in the management of moderate knee OA.

The randomized double-blind, parallel-group clinical trial included 122 patients (56 males and 66 females) aged between 40 and 75 years with moderate knee OA took place in three different centers

Participants were divided evenly into 2 groups (n= 61) the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally10 mg twice daily of CSE in a 180-day intervention.

According to the results from the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), the WOMAC score of CSE group was decreased by 22.44% and 70.29% on Days 30 and 180, respectively, compared to a 14.80% and 32.81% to the decrease in the GC group.

Similarly, the GC also showed a decrease of pain score compared to the CSE group without inducing any adverse effect.

Based on the finding, researchers said, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".

In order to reveal additional information about the anti-inflammatory properties of cucumber, researchers examined the antioxidant effect on cucurbitacins (Cub), a major compound found in the fruit.

Compared to grape-seed extract, wheat, alfalfa, and ginkgo biloba extracts, CuB showed a broad spectrum radical-scavenging capacity.

CuB exerted a similar activity to that of the aforementioned study by inhibiting the expression of TNF in macrophages and lymphocytes and the expression of pro-inflammatory mediators such as nitric-oxide synthase-2 and cyclooxygenase-2.

Collectively, Dr. Adebowale Bernard Saba, the lead scientist wrote," It is general knowledge among researchers working with natural medicinal products that any of the cucurbitacins have the attributes or the potential to become fully patented as anti-inflammatory...drug".

Taken altogether, cucumber processed abundantly amount of CuB may be used for the treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Search for a novel antioxidant, anti-inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba and Olayinka Oridupa. (R esearch Gate)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Do and do not’s list by Kyle J. Norton.

Herbal Turmeric Protects the Kidneys Against Renal Toxicity

By Kyle J. Norton

Renal toxicity or nephrotoxicity in most cases is toxicity in the kidneys caused by toxic chemicals and medications.

The kidneys, a pair of bean-shaped organs on either side of your spine are the second detoxed organ after liver by removing wastes or toxins in the blood come from the normal breakdown of active muscle and from the food you eat.

Most common symptoms of renal toxicity may cause reduced kidney function in eliminating toxins, leading to a reduced amount of urine. swelling of your legs, ankles, and feet from retention of fluids.
In a serious case, the condition can also result in unexplained shortness of breath. excessive drowsiness or fatigue. persistent nausea. confusion. pain or pressure in your chest.

Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.

* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.

Depending on the severity of kidney damage, kidney disease can range from mild to severe, including kidney failure.

Conventionally, most cases of the renal toxicity are treated with cisplatin often associated with an acute kidney injury. Long-term intake of the aforementioned drugs has been found to elevate the risk of nausea and vomiting, kidney toxicity, hearing loss, ringing in the ears particularly blood abnormalities of low levels of magnesium, calcium, and potassium.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of renal toxicity scientists investigated the nephroprotective effect of essential oils from Nigeria ginger and turmeric rhizomes in cadmium-treated rats.

Injection of essential oils from ginger and turmeric rhizomes exerted a significant anti-inflammatory effect by preventing alterations of renal function markers induced by cadmium.

Futhermore, the combination also inhibited the levels of cytokines such as IL-6, IL-10, and TNF-Alpha) levels in Cd-treated rats.

Moreover, renal adenosine deaminase (ADA) activity. in Cd-treated rats also decreased by the injection of the combined essential oils from ginger and turmeric rhizome.

Based on the finding, researchers write in the final report, "inhibition of ADA activity and modulation of inflammatory cytokines could be suggested as the possible mechanism of action by which essential oils from ginger and turmeric rhizomes exert their nephroprotective activities".

Furthermore, in 1,350 participants selected to the study were randomly divided into either curry intake group with the consumption of a curry dish more than once a month over the previous year, or a non-curry intake group (n = 747), researchers found that according to the heavy metal analysis, the curry intake group showed significantly lower heavy metal blood concentrations (Pb, Hg, and Cd).

However, the levels of heavy metals in the patients with hypertension were significantly lower in curry intake group compared to the nonhypertension group.

The levels of blood concentrations of heavy metals induced toxicity associated with the induction of hypertension were significantly lower compared to the placebo.

In other words, turmeric has a potential effect on reducing renal toxicity.

In order to obtain more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac toxicity in rats.

According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced nephrosis.

Additionally, turmeric extract inhibited the DOX-induced increase in plasma creatine kinase (CK) associated with the increased risk of kidney disease.

Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the renal.....toxicities".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of kidney toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nephroprotective Effect of Essential Oils from Ginger (Zingiber officinale) and Turmeric (Curcuma longa) Rhizomes against Cadmium-induced Nephrotoxicity in Rats. by Akinyemi AJ1, Faboya OL2, Paul AA3, Olayide I1, Faboya OA4, Oluwasola TA. (PubMed)

(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)

Bromelain Promotes and Removes Eschar In Burn Wounds, Human Trials Show

By Kyle J. Norton

Eschar is a dry, dark scab of dead skin associated with a certain skin condition.

Most cases of eschar are associated with burning or cauterizing that stop bleeding, or prevent the spread of infection.

Most common causes of eschar are burned, a condition that causes severe skin damage. Burn wound can recover without serious health consequences in a few days or weeks depending on the size of the burns.

Burns depending on the severity can be classified into
* First-degree burns affect only the epidermis or outer layer of the skin accompanied by the symptoms of is red, painful, dry, and with no blisters on the affected site.

* Second-degree burns affect the epidermis and part of the dermis layer of the skin accompanied by the symptoms of red, blistered, and swollen and painful on the affected site.

* Third-degree burns not only to destroy the epidermis and dermis but also damage the underlying bones, muscles, and tendons accompanied by no symptoms due to completely damage of the nerves in the area.

Believe it or not, 10 percent burns of a child's body and 15 to 20 percent burns of an adult's body are considered to be major injuries and require medical attention and hospitalization.

Most common types of burns are

* Thermal burns caused by external heat sources.

* Radiation burns caused by prolonged exposure to ultraviolet rays of the sun or radiotherapy.

* Chemical burns caused by acids, alkalies, detergents, or solvents.

* Electrical burns caused by electrical current.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of diabetic foot burns, researchers examined the effect of bromelain-based enzymatic debridement with Nexobrid® (Mediwound) on surgical tangential excision of deep dermal and full thickness burns.

According to the retrospective case series that identified four patients with diabetic foot burns,
Nexobrid® debridement showed significant activity in the development of further eschar and deepening of their wounds a few days after NexoBrid was applied.

In other words, Nexobrid® debridement protects the skin against the formation of dry, dark scab or falling away of dead skin due to surgical tangential excision of deep dermal and full thickness burns.

Based on the finding, Dr. Berner JE, the lead scientist said, "We would recommend judicious use of this new product in patients with diabetic foot wounds".

Moreover, the joint study led by the University of Heidelberg based on the mutual experience of applying enzymatic debridement in more than 500 adult and pediatric patients by the consensus panelists suggested that the degree of consensus was remarkably high, with a unanimous consensus in 88.2% of statements, and the lowest degree of consensus of 70% in only 3 statements.

More precisely, most patients support the use of Nexobrid® debridement for the treatment of removed eschar in burn wounds and reduced blood loss.

After taking other factors into account, Dr. Hirche C, the lead researcher wrote, "This consensus document may serve as a preliminary guideline for the use of enzymatic debridement with user-oriented recommendations until further evidence and systematic guidelines are available".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of eschar in burn wounds, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Limitations to the use of bromelain-based enzymatic debridement (NexoBrid®) for treating diabetic foot burns: a case series of disappointing results by Berner JE1,2, Keckes D1, Pywell M1, Dheansa B. (PubMed)
(2) Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus by Hirche C1, Citterio A2, Hoeksema H3, Koller J4, Lehner M5, Martinez JR6, Monstrey S3, Murray A7, Plock JA8, Sander F9, Schulz A10, Ziegler B11, Kneser U. (PubMed)
(3) Burn Stages and Types of burn by the Stanford Health Care

Monday, 10 June 2019

Herbal Bilberry, the Natural Remedy that Prevents and Slows Progression of Parkinson's disease (PD)

By Kyle J. Norton

Parkinson's disease (PD) is a chronic and medical condition that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.

In other words, Parkinson's disease is a progressive central nervous system disorder that affects neurons in transmitting messages in controlling the movement.

Some patients in the very early stage of PD may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.

Researchers do not know why the neurons in the brain in some people are susceptible to gradually break down or die while others do not even they have similar health conditions and from the same family.

However, they do know, according to the epidemiological study, aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the risk factors found in patients with PD.

Please note that most people process some of the conditions have never developed Parkinson's disease.

Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink caffeine found in coffee, tea and cola are less likely to get Parkinson's disease compared to those who don't.

Dr. Prediger RD at the Universidade Federal de Santa Catarina wrote, "Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population older than 60 years".

And, "The available data also suggest that caffeine can improve the motor deficits of PD and that adenosine A2A receptor antagonists such as istradefylline reduces OFF time and dyskinesia associated with standard 'dopamine replacement' treatments".

The results strongly suggested if you drink caffeinated beverages, your risk of PD is decreased substantially.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a natural ingredient which processes neuroprotective effects against Parkinson's disease, researchers examined the Anthocyanin-rich preparations of Vaccinium species, including bilberry against the oxidative damage in dopaminergic neurons.

V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins showed a significant neuron protection activity by inhibiting oxidation caused by the chain reaction of reactive oxygen species (ROS).

The application was found to be 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.

According to the analysis of the chemical constituents, the neuroprotective effects were attributed to the presence of bioactive compounds anthocyanins and total cyanidins found abundantly in bilberry, but not quercetin or myricetin.

The results suggested that the high potency of anthocyanins processes a potentially neurotoxic reaction against the onset of Parkinson's disease.

Dr. Yao Y, the lead scientist wrote, "(the findings) provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of Parkinson's disease, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease--phagocyte influx to the brain is promoted by bilberry-enriched diet by Virel A1, Rehnmark A1, Orädd G2, Olmedo-Díaz S1, Faergemann E1, Strömberg I. (PubMed)
(2) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(3) Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms by Prediger RD. (PubMed)

Phytochemical Betacyanins Kills Bladder Cancer Cells In Vitro

By Kyle J. Norton

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women. Usually, bladder cancer starts from cells on the surface of the inner lining of the bladder caused by several types of malignant growths of the urinary bladder cells.

Depending on the cancer cell originated bladder cancer can be classified into

* Transitional cell carcinoma
Transitional cell carcinoma starts on the innermost tissue layer of the bladder. More than 90 percent of bladder cancers begin in the transitional cells

* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin squamous cells.

* Adenocarcinoma
Cancer begins originates in glandular tissue of the bladder, including the surface layer of skin, glands and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.

According to the statistics, most cases (90%) of bladder cancer are diagnosed in people older than 55, and the average age people are diagnosed with bladder cancer is 73 worldwide.

Believe it or not, bladder cancer will cause the death of 12,870 in men and 4,800 in women. Among men, bladder cancer is the eighth most common cause of cancer death.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With the aim to find a potential compound for the treatment of bladder cancer, researchers examined the effect betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) alone or in combination with vitexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L.on T24 bladder cancer cells.

According to the tested differentiation, the combination of BC and XVX exhibited a synergistic effect on the inhibition of proliferation in T24 cancer cells at 24 and 48 h but not after 72 h of incubation.

Furthermore, according to the observation of the means of fluorescence activated cell sorting (FACS) analysis, the combined treament induced cancer cell apoptosis through activating the protein associated with cell death signaling.

In cell death analysis, the combination promoted the expression of genes involved in pro-apoptosis and inhibited the genes associated with anti-apoptosis in bladder cancer cell lines.

Moreover, the combined treatment also demonstrated strong activity in the induction of cytotoxicity against bladder cancer cells without affecting the normal human skin NCTC 2544 keratinocytes.

Based on the finding, Dr. Emanuele Salvatore Scarpa, the lead scientist wrote, "These results demonstrated the efficacy and the mechanisms of the action of BC and XVX, extracted from edible plants, and suggested that a diet or a nutrition supplement, enriched with these bioactive molecules, could be used in the prevention of human bladder cancer".

Taken altogether, betacyanins used alone or combined with herbal remedy may be considered a remedy for the prevention and treatment of bladder cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Emanuele Salvatore Scarpa, Monica Emanuelli, Alessandra Frati, and Valentina Pozzi (Research Gate)
(2) Bladder Cancer by Kyle J. Norton