Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Saturday, 8 June 2019

Bromelain, a Natural Treatment of Pelvic Pain with No Side Effects

By Kyle J. Norton

The pelvic girdle or hip girdle is formed by a single bone which serves as the attachment point for each lower limb.

Pelvic pain is a pain in the lowest part of the abdomen and pelvis.

In women, pelvic pain in most cases is associated with the symptoms arising from the reproductive, urinary or digestive systems.

In women, the most common causes of pelvic pain are

* Adenomyosis is a condition associated with menstrual cramp caused by the inner lining of the uterus that breaks through the muscle wall of the uterus. Adenomyosis has a negative influence on the quality of life of patients.

* Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else instead of the inside of the uterus. Endometriosis also reacts to the women menstrual cycle, leading to severe menstrual pain with maturation with no way to escape.

* Premenstrual syndrome is a faulty function of the ovaries related to the women's menstrual cycle, affecting over 70% to 90% of women in the US. The syndrome also interferes women's physical and emotional states, and daily activities as a result of hormone fluctuation that occurs one to two weeks before menstruation and then declines when the period starts.

* Mittelschmerz is one-sided, lower abdominal pain associated with ovulation occurred in the midway through a menstrual cycle, about 14 days before the next menstrual period.

Conventionally, treatment of pelvic pain is to relieve pain with over-the-counter pain medicine, such as aspirin, ibuprofen (Advil, Motrin IB, others) or acetaminophen (Tylenol, others).

If you are a long-term user of pain relievers, please make sure you know all the side effect for preventive measure.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for the treatment of pelvic pain, researchers evaluated the efficacy of bromelain affected by chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

The study included patients diagnosed with CP/CPPS between January and December 2015 were randomly assigned to receive oral capsules of pollen extract and vitamins (group A) or bromelain (group B) for 3 months.

According to the returned of completed questionnaires from the 65 male patients, 8 of the 33 patients in the bromelain group showed a significant reduction in the NIH-CPSI total score compared to b24 of the 32 patients in group A.

In other words, pollen extract and vitamins (group A) treated group exerted a better outcome after 3 months of treatment.

Furthermore, levels of pro-inflammatory cytokines were significantly lower in group A compared to group B.

In the follow-up visit, group A showed a statistically significant reduction in the levels of IL-8 compared to the enrolment levels, compared to group B.

These results suggested that the efficacy of both pollen extract and vitamins (group A) and bromelain (group B) relief the pelvic pain through their anti-inflammatory activities, particularly in IL-8.

Taken altogether, bromelain may be considered a remedy for the prevention and treatment of pelvic pain, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) The Clinical Efficacy of Pollen Extract and Vitamins on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Is Linked to a Decrease in the Pro-Inflammatory Cytokine Interleukin-8 by Cai T1, Verze P2, La Rocca R2, Palmieri A2, Tiscione D3, Luciani LG3, Mazzoli S4, Mirone V2, Malossini G. (PubMed)

Phytochemical Carotenoids Ameliorates the Risk of /Stomach Cancer

By Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.
Gastric/Stomach cancer is a medical condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric/stomach cancer.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man lifetime is about 1 in 95.

The exact causes of gastric/stomach cancer are unidentified. However, researchers do no certain risk factors are associated with an increased risk of the disease, including

* Age

Most cases of gastric/stomach cancer are found in adult at their fifty.

*Diet
Exposure to certain chemical carcinogens in the foods of the first 20 years of life or over a prolonged period of time may increase the risk of gastric/stomach cancer.

* Bacteria
Researchers found that people with gastric/stomach cancer also contains bacteria Helicobacter pylori in their stomach.

* Hydrochloric acid production
People with the low amount or no of hydrochloric acid produced by the stomach are at risk to develop gastric/stomach cancer

* Long-term inflammation of the stomach
People who have conditions associated with long-term stomach inflammation are at slightly increased risk of gastric/stomach cancer.

* Family history
The risk of gastric/stomach increases if one of the members of your direct family has it.

* Smoking is associated with gastric/stomach due to cigarette carcinogens.

* Obesity
Researchers found that overweight and obesity are associated with an increased risk of gastric/ stomach cancer. The strength of the association also increases with increasing BMI.

However, most people with some of the aforementioned risk factors have never developed gastric. stomach cancer.

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

On finding a natural pigment for the prevention and treatment of gastric/stomach cancer, researchers examined the effects of carotenoids, the fat-soluble pigments found abundantly in fruits and vegetables including total dietary carotenoids, dietary carotenoid subclasses (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene), and foods contributing to the dietary intake of each carotenoid on the risk of GC.

According to the results of case-control study of 415 cases and 830 controls recruited from the National Cancer Center Hospital in Korea between March 2011 and December 2014,
* Intake of carotenoids exerted a significant inverse association with GC risk among women, with the relative odds ratio (OR) of 0.56.

* A higher intake of dietary lycopene was inversely associated with GC risk overall in the subjects with OR 0.60. In men, the OR was 0.60 compared to women with OR of 0.54.

* In the subgroups of Helicobacter pylori (H. pylori)-positive subjects, dietary lycopene intake demonstration a strong impact on GC risk was also observed in the subgroups of Helicobacter pylori (H. pylori)-positive subjects and ever smokers.

Compared foods containing a high amount of carotenoids and lycopene, consumption of tomatoes and tomato ketchup was inversely associated with GC risk in the overall subjects, men, and women.

Based on the findings. researchers wrote, "Based on our findings, a higher intake of dietary lycopene and contributing foods of lycopene (tomatoes and tomato ketchup) may be inversely associated with the risk of GC".

Taken altogether, carotenoids containing a high amount of compound lycopene may be considered a remedy for the prevention and treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Dietary Carotenoids Intake and the Risk of Gastric Cancer: A Case-Control Study in Korea by Kim JH1, Lee J2, Choi IJ3, Kim YI4, Kwon O5, Kim H6, Kim J. (PubMed)
(2) Stomach Cancer/Gastric Cancer by Kyle J. Norton

Friday, 7 June 2019

Phytochemical 3,3'-Diindolylmethane Protects the Liver Against Hepatic Fibrosis Developing

By Kyle J. Norton

Hepatic fibrosis is a condition caused by scars tissues buildup on the liver which limits the function of the liver.

Most cases of hepatic fibrosis is a result of an imbalance of production and dissolution of collagens in extracellular matrix caused by overproduction of proinflammatory cytokines in the acute phase of infection or interruption in the stages of healing.

Hepatic fibrosis is an early stage of cirrhosis, a leading cause of liver failure and liver cancer.

Patients with hepatic fibrosis are asymptomatic. However, long-term accumulated of liver scar induced cirrhosis can cause symptoms of jaundice, variceal bleeding, ascites, a condition of the accumulation of protein-containing fluid within the abdomen and portosystemic encephalopathy.

According to the statistics provided by the Johns Hopskin Medicine, cirrhosis and other chronic liver diseases are common disease-related causes of death in the U.S. Approximately 31,000 people in the U.S. die each year from cirrhosis.

In hepatitis C virus perspective, approximately 3.5 to 4.6 million people in the U.S. are chronically infected with the virus, leading to the death of 2,000 people annually.

Most cases of the advanced stages of liver fibrosis are treated by liver transplantation. However, according to the University of California in the development of new therapy for the treatment of liver fibrosis, targeting the steps in HSC activation may be a therapeutic target for liver fibrosis.

A list of the targets can be found by clicking the link (2) of the reference area. Please read Fig. 5 Proposed therapies for liver fibrosis.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

With an aim to find a potent natural ingredient for the treatment of hepatic fibrosis with no side effects, scientists evaluated the effects of 3,3'-Diindolylmethane (DIM) on excessive collagen deposition produced by activated hepatic stellate cells (HSCs).

Both HSC-T6 cell line and primary HSCs included in the study were examined for the expression of α-smooth muscle actin and collagen I, after injection of DIM.

During the experiment, DIM inhibited the expression of miR-21 by deactivating the underlying HSC through suppressing the signaling pathway associated with cell differentiation linking to inflammation and autoimmunity.

Where overexpression of microRNA-21 (miR-21) has been found to play a crucial role in the biological functions and diseases, including development, cancer, cardiovascular diseases, and inflammation.

The inhibition of miR-21 overexpression was attributed to the effect of DIM in the modulation of the activity of the transcription factor, AP-1, a transcription factor that plays an essential role in the regulation of gene expression in response to a variety of stimuli, including cytokines, growth factors, stress.

The findings suggested that DIM in vivo process the potential in attenuating liver fibrosis induced by thioacetamide, according to the assessment of the collagen deposition and profiles of profibrogenic markers.

Dr. Zhang Z, the lead scientist wrote in the final report, "DIM shows potential as a therapeutic agent for the treatment of hepatic fibrosis".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of hepatic fibrosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression by Zhang Z1, Gao Z, Hu W, Yin S, Wang C, Zang Y, Chen J, Zhang J, Dong L. (PubMed)
(2) New Developments on the Treatment of Liver Fibrosis by Yukinori Koyama, Jun Xu, Xiao Liu, and David A Brenner. (PMC)

Phytochemical Betacyanins, the Natural Free Radical Scavengers

By Kyle J. Norton

Free radical scavengers are antioxidants that gobble up free radical before they can cause a chain of reaction.

Most common types of free radical scavengers are catalase, glutathione peroxidase, superoxide dismutase (SOD), vitamin A, C, D, and E.

Free radicals are highly unstable molecules. They can be everywhere. Internally, free radicals are produced in our body during the process of cell metabolism. Externally, free radicals can enter our body from the environment sources, such as the air we breathe, the food we eat and the water we drink.

In other words, any chemical compounds or molecules which process oxygen atom can be free radical after chemical interaction.

Oxidative stress is a result of overexpression of free radical-induced by a chain reaction that can not be stopped due to reduced levels of antioxidant enzymes produced by the body.

Why? overexpression of free radicals causes lipid peroxidation by oxidizing the free and ester forms of unsaturated fatty acids and cholesterol through three distinct mechanisms, including free radical-mediated chain reaction, enzyme-mediated oxidation, and nonradical, nonenzymatic oxidation.

Over time, oxidative stress can damage the lipid, and protein and induce the alternation of healthy cell DNA.

How important free radical scavengers to our body? Dr. Milind S Hatwalne in the investigation of the effect of free radical scavengers in anesthesiology and critical care wrote, "Free radicals are highly reactive and unstable compounds. They play a central role in the mechanism of cell injury and cell death".

And, "Free radical scavengers either prevent these reactive species from being formed or remove them before they can damage vital components of the cell" and "Several clinical trials have been performed in order to reduce oxidative stress by supplementation of antioxidants alone or in combination with standard therapies. Antioxidant supplementation at an early stage of illness may lead to improved therapies in the treatment of critically ill patients".

In other words, antioxidants with free radical scavenging activity may protect the body against the damage of various cellular components.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of betacyanins as free radical scavengers.

By analyzing the compound in betacyanins, researchers found that
* Betanin was a weak free radical scavenger in the free radical chain-breaking probably due to kinetic solvent effects on its solubility, stability and reaction rates and partition in lipid bilayers (a thin polar membrane) activity.

* Betanidin also found in betacyanins behaved as a chain terminating antioxidant in the liposomal model,.particualrly in peroxyl radical-scavenging activity

The finding strongly suggested that betacyanins exhibit chemical reaction of betanin and its glycone betanidin towards peroxyl radicals generated from the azo-initiated oxidation.

Additionally, in the peroxyl radical generating system with the presence of AAPH and NO-generating system, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllotactic and betanidin.

According to the tested assays, betacyanins induced peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).

Furthermore, betacyanins also reduced the nitrite-level in the low concentration range of 2.5-20 μM.

In chemical ingredients differentiation, the IC₅₀ values (μM) of nitrogen radical scavenging activity were 24.48, 17.51 and 6.81 for betanin, phyllocactin and betanidin.

Based on the results, Dr. Taira J, the lead scientist wrote, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".

Taken altogether, betacyanins may be considered free radical scavenger to terminate the oxidative reaction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Free radical scavengers in anesthesiology and critical care by Milind S Hatwalne. (PMC)

Healthy Kitchen Spice Turmeric, a Natural Prevention and Treatment of Liver Cancer

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

Futhermore, the liver produces bile that not only aid the digestive function in food absorption but also builds strong cell membranes, produces vitamin D and steroid hormone.

Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body

Liver cancer is a medical condition characterized by out of controlled growth of hepatocellular cells in the liver. Most cases of liver cancer start in the cells on the surface of the inner lining of the liver tissue, before penetrating into deeper layers to form a tumor.

At the advanced stage, primary liver cancer can also travel a distance away to infect other healthy tissues and organ, leading to secondary metastasis.

Since the liver is an organ with soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer.

According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. In the US, approximately 42,030 new cases including 29,480 in men and 12,550 in women will be diagnosed with liver cancer. The liver cancer also will cause of 31,780 American, including 21,600 men and 10,180 women in 2019.

Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

Most common symptoms of liver cancer are abdominal pain, tenderness, easy bruising or bleeding, enlarged abdomen, jaundice, severe pain, particularly in the later stage and drowsiness and confusion accompanied by the general symptoms shared by other types of cancer.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding potential and natural compound for the treatment of liver cancer, researchers investigated curcumenol and laminarin, the bioactive compounds found in turmeric and kelp respectively.
In vitro, according to the tested assays, the combination of curcumenol and laminarin inhibited the proliferation, migration, and invasion in human hepatoma HepG2 cells.

Furthermore, the combination of curcumenol and laminarin also has a strong effect on the inhibition of HepG2 cell proliferation and metastasis.

In other words, the efficacy of the combination was attributed to the inhibition of the expression of the levels of cystathionine beta-synthase (CBS, an endogenous hydrogen sulfide (H2S) synthetase) level associated with cancer initiation and progression

Where the increased expression of cystathionine beta-synthase has been found in cancer cells of various tissue types.

Moreover, the combined production also blocked the angiogenesis of liver cancer cell by positively regulating the vascular endothelial growth factor (VEGF).

Based on the finding, researchers wrote, " the combination of Curcuma zedoary and kelp could inhibit the proliferation and metastasis of liver cancer cells in vivo and in vitro by inhibiting endogenous H2S production and down-regulating the pSTAT3/BCL-2 (apoptotic) and VEGF (metastatic) pathway".

Additionally, in the examined secondary liver cancer caused by primary gastric cancer (PGC) metastasis, researchers found that injection of curcumin, an active ingredient from the rhizome of the plant Curcuma longa reduces the incidence of metastatic tumor formation in the liver in vivo.

In mice induced primary gastric cancer treated with curcumin treatment, the circulating tumor cells (CTCs) significantly reduced the formation of liver tumor.

More precisely, curcumin also blocked the expression of CXCR4 in primary tumor cells associated with the cancer cells survival, metastasis, and recurrence.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of primary and secondary liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Combination of Curcuma zedoary and kelp inhibits growth and metastasis of liver cancer in vivo and in vitro via reducing endogenous H2S levels by Han H 1, Wang L, Liu Y, Shi X, Zhang X, Li M, Wang T. (PubMed)
(2) Curcumin inhibits liver metastasis of gastric cancer through reducing circulating tumor cells by Gu X1, Zhang Q1, Zhang W2, Zhu L. (PubMed)

Cucumber's Cucurbitacin B (CuB) Blocks the Skin Cancer Proliferation in Vitro

By Kyle J. Norton

Skin cancer is a chronic and medical caused cell growth disorderly and uncontrollably due to the alternation of DNA.

Most cases of skin cancer begin in the cells on the surface of the inner lining, before proliferating to other tissues through cell cycle division.

Compared to normal cells with a limit of cycle division, the cancer cell can divide indefinitely. Some tumor can also stimulate the production of the new vessels to provide them with additional energy from the preexist vessel.

Most common types of skin cancer are

* Basal cell cancer
It is the most common type of skin cancer as a result of abnormal growth of the cells in the lowest layer of the epidermis, accounting more than 90% of all skin cancer in the U.S.

* Squamous cell cancer
Squamous cell cancer arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.

* Melanoma
Melanoma is a result of malignancy of melanocytes, which are the cell produced dark pigment for your skin.

Most common symptoms of skin cancer are abnormal skin patches, such as flat, scaly, brown or flesh-colored patches, a white, waxy scar-like sore, scaly red skin lesion, skin bump or lump, sore that won't heal, unintentional weight loss and non-healing ulcer, especially on lip or ears.

If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound which processes anti-skin cancer property, researchers investigated cucurbitacin B (CuB) effect, a major compound found in cucumber on cutaneous squamous cell carcinoma (CSCC).

According to the tested analysis, CuB inhibited 50% growth (ED50) of the CSCC cell lines (SRB1, SRB12, SCC13, COLO16) in liquid culture at 4 x 10(-7)-10(-5) M.

At 10(-7) M, CuB inhibited nearly all of the CSCC clonogenic cells used in the study through cell cycle arrest.

Interestingly, injection of Cub exerted cancer cell morphologic changes within 60 min. Moreover, Cub (10(-8)-10(-6) M, 3-24 h) was effective in inhibiting the proteins associated with SRB1 and SRB12 cell lines proliferation by disrupting the cell cycle division.

The migration of SRB1 and SRB12 cells was also suppression by the injection of 10(-7) M CuB.

Most importantly, CuB exerted the synergistic potentiation of the anti-proliferative effect of cisplatin in CSCC.

In other words, CuB suppressed the cancer cell progression linearly in a dose-dependent manner through its G2/M cell cycle arrest

Based on the findings, researchers wrote, "CuB has a prominent anti-proliferative activity on CSCC cells".

Taken altogether, cucumber processed a high amount of CuB may be used for the treatment of skin cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines by Chen W1, Leiter A, Yin D, Meiring M, Louw VJ, Koeffler HP. (PubMed)

Thursday, 6 June 2019

Phytochemical Alliin Inhibits the Onset of Hypercholesterolemia

By Kyle J. Norton

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

In other words, the condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).

Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.

Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. In patients with familial hypercholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people hypercholesterolemia are getting treatment.

Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that the widespread obesity due to the promotion of a high-fat diet over the past few decades may have a strong impact in the increased the incidence in the US.

Dr. Jeannie Chan, the lead scientist wrote, "ApoE deficient mice, generated by gene targeting, have a lipoprotein profile similar to humans in that most of the plasma cholesterol is carried on VLDL and IDL particles rather than HDL particles as in non-genetically modified mice. ApoE-/- mice have elevated levels of plasma cholesterol even on a chow diet and develop atherosclerotic lesions spontaneously. Advanced lesions with plaque rupture that resemble those in humans have frequently observed in apoE-/- mice fed an HCHF diet, and these mice are used for developing drugs to reduce atherosclerosis".

In other words, a high-fat diet promoted the genes associated with cholesterol secretion.

With an aim to find a potential ingredient for the treatment of hypercholesterolemia, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.

New Zealand rabbits selected to the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.

According to the Western blot analysis, WGLL protected the heart by improving aortic and coronary flow.

WGLL was also found to inhibit the atherosclerotic plaque coverage.

Furthermore, WGLL also reduced the risk of hypercholesteremia by significantly reducing the plasma levels of low-density lipoprotein.

Based on the findings, researchers said, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".

Taken altogether, alliin may be considered supplements for the prevention and treatment of heart disease associated with hypercholesterolemia, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Animal Models of Diet-induced Hypercholesterolemia By Jeannie Chan, Genesio M. Karere, Laura A. Cox and John L. VandeBerg.