Herbal Turmeric Protects the Kidneys Against Drugs, Heavy Metals and Substances Toxicity

By Kyle J. Norton


The kidneys are a pair of kidney shape organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.

More than a detoxed organ, the kidneys also maintain the body fluid balance, regulate the production of red blood cell and high blood pressure.

Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.

Chronic kidney disease (CKD)  is a slow and progressive disease which can lead to kidney failure over time.

At the advanced of CKD can cause the dangerous levels of fluid, electrolytes and wastes build up in the body.

According to statistics, approximately 14 percent of the US general population suffer from CKD. Believe it or not, more than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.

Out of many risk factors associated with CKD, some researchers suggested high blood pressure is one most prevalent risk factor found in most patients.

The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"

And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound with the kidney protective property, researchers investigated curcumin, a major phenolic compound the rhizome of the Curcuma species anti kidney toxicity.

In glucose, tartrazine, induced toxicity, curcumin protected the kidney against DNA damage in leucocytes.

In a streptozotocin-induced diabetes rat model, curcumin protected the kidney against overexpression of free radical to cause kidney cell damage through its antioxidant activity.

In the long term heavy metal model,  curcumin inhibited the toxic effect caused by the accumulation of the metal in the induction of kidney cell damage.

In an animal model induced cisplatin-induced acute kidney injury by injection cisplatin, curcumin enhanced the function of cisplatin-resistant cancer cells and decrease its unwanted side effects.

More interestingly, curcumin inhibited the nicotine receptors on kidney cells that link nicotine to accelerated kidney damage in cigarette smokers

In other words. if the kidneys are less able to excrete nicotine, in long term, accumulated of the extracellular fluid and blood volumes increase, that can lead to severe kidney damage.

In other studies, kidney damage caused maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate also reversed by the injection of curcumin, similar to those of the aforementioned substances.

Taken altogether, turmeric and its bioactive compound curcumin may be considered remedies the prevention and treatment of kidney damage, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Protective effects of curcumin against toxic agents-induced renal failure: a review by Farkhondeh T1, Samarghandian S2, Azimi-Nezhad M2, Shahri AMP. (PubMed)
(3) High Blood Pressure and Chronic Kidney Disease by The Natural Kidney Foundation 

Healthy Food Tomato, A Potential and Natural Prevention and Treatment of Cancer

By Kyle J. Norton

Cancer is a class of chronic and medical condition caused by cell growth irregularly in the tissues of the body.

Cancer can be classified into
* Primary cancer or original cancer is a tumor at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

* Secondary metastasis is tumor spread from primary cancer.

Most cases of cancer begin in the cells on the surface of the inner lining of the organs' tissues. For example, breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell growth to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cells growth is necessary to prevent further damage to the body tissues and organs, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors. 

However, in cancer, mutated cells can grow indefinitely by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death, leading to the formation of cell mass or tumor.

The exact causes of cancer are unidentified. Researchers can not explain why people with the same health conditions and family history in the same family, some are prone to cancer development while others do not.

According to the statistic, In 2018, approximately 1,735,350 new cases of cancer were diagnosed in the United States. The diseases also cause the death of 609,640 Americans in the same year.

Believe it or not, cancer mortality is higher among men than women (196.8 per 100,000 men and 139.6 per 100,000 women), according to the National Cancer Institute.

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural ingredient for the prevention and treatment of cancer with no side effects researchers examined several HDACi of natural and dietary origin such as tomatoes against cancer developing.

Where histone deacetylase inhibitors (HDACi) regulated the activity of histone deacetylase enzymes (HDACs) has been used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy.

According to the differential, HDACi exhibited antitumor effect by the activation of cell cycle arrest, induction of apoptosis and autophagy, angiogenesis inhibition.

Furthermore, the cancer inhibition of HDACi is also found in increased reactive oxygen species generation that causes oxidative stress, and mitotic cell death in cancer cells.

In order to reveal more information about tomatoes anti-cancer property, scientists investigated lycopene loaded whey protein isolate nanoparticles (LYC-WPI-NPs) anti-cancer activity.

The percent lycopene entrapment of prepared LYC-WPI-NPs was estimated in the range to 50 and 65%.

The WPI-NPs was found to enhance the oral bioavailability and absorption of lycopene by controlling its release from nano-formulation and lymphatic pathways.

Moreover, lycopene improved the biopharmaceutical attributes of lycopene and demonstrated prophylactic anticancer activity, decrease tumor proliferation and increased the survival rate of treated animals, in the form of loaded protein nanoparticles.

Taken altogether, tomatoes processed high amounts of lycopene may be considered a functional food for the treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy by Singh AK1, Bishayee A2, Pandey AK. (PubMed)
(2) Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity by Jain A1, Sharma G2, Ghoshal G3, Kesharwani P4, Singh B5, Shivhare US4, Katare OP. (PubMed)

Phytochemical 3,3'-Diindolylmethane Inhibits Parameters Associated with the Onset of Hyperglycemia

By Kyle J. Norton


Hyperglycemia is a condition of abnormally high blood sugar in the bloodstream associated with diabetic complications in patients with type 2 diabetes.

In order words, hyperglycemia is a result of the body which isn't properly using or doesn't make the hormone insulin.

Hyperglycemia is also considered a hallmark of patients with type 2 diabetes. Another hallmark is insulin resistance.

The condition occurs mostly due to poor control and management in patients with diabetes such as
a poor diet, physical inactivity choices, symptoms of medicines intake.

Some patients with diabetes also experience symptoms of hyperglycemia due to skipping not taking enough glucose-lowering medication.

Most common symptoms of hyperglycemia are frequent urination, increased thirst, blurred vision, persistent fatigue, and headache.

If you are having some of the aforementioned symptoms, you may have hyperglycemia. Please make sure you check with your doctor to prevent the longer-term untreated complications.

According to the epidemiological studies, untreated or long term persistently hyperglycemia in patients with diabetes has been found to induce serious symptoms such as shortness of breath,  confusion, and coma.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

With an aim to find a natural ingredient for the treatment of hyperglycemia in patients with type 2 diabetes, researchers examined the effect of the nutritive phytochemicals, indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) on oxidative stress developed in type 2 diabetes mellitus (T2DM).

The study is carried out on the genetically modified mouse (C57BL/6J mice) similar to those of metabolic abnormalities of the human disease after the administration of a high-fat diet (HFD).

Injection of DIM and I3C positively modulated the glucose, insulin, and hemoglobin (Hb), glycated hemoglobin (HbA1c) level, an indication of the hyperglycemically modulatory activities in the tested HFD mice.

Compared to the HFD group, treatment groups showed a decrease in the levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), conjugated dienes (CD associated with oxidative stress in lipid peroxidation.

Futhermore, DIM and I3C also improved the antioxidant enzymes produced by the host observed by the increasing SOD, CAT, GPx levels in the erythrocyte, liver, kidney, and heart.

Levels of free radical scavengers such as vitamin C, vitamin E, and GSH levels are also increased in the plasma, liver, kidney, and heart in diabetic mice.

In other words, DIM and I3C protected diabetic mice against diabetics complications by modulating blood glucose and lipid by balancing the ratio of free radicals and antioxidant in the tested subjects.

Based on the finding, researchers wrote in the final report, "the antioxidant-scavenging action was accelerated in mice treated with DIM than the I3C treatment group which was comparable with the standard drug metformin".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane in C57BL/6J mice by Jayakumar P1, Pugalendi KV, Sankaran M. (PubMed)

Herbal Turmeric Effects on Skin Health

By Kyle J. Norton


Skin, a large external organ in the human body is the outer layer, with a total area of about 20 square feet which protect the internal organs, bones, and tissues against damage.

The skin processes 3 main layers

* Epidermis is the outer most layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.

* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.

* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.

Skin health refers to the use of material or agents, including topical and oral herbal remedies with the function to protect the skin cell against the environment harmful substance, including the sun UV light and microbial infection.

Some researchers suggested that by providing enough nutrition to the skin cells we can maintain healthy skin. In other words, macronutrients including carbohydrates, proteins, and lipids and micronutrients such as vitamins and essential minerals all work together to maintain healthy skin.

More precisely, we can maintain healthy skin by eating a healthy diet accompanied by moderate exercise and avoid exposure of skin to harmful substances.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural compound for the enhancement of skin health, researchers examined the active component of turmeric, curcumin used medically to treat a variety of dermatologic diseases in traditional medicine.

The search involved the relationship between products containing turmeric, curcumin, and skin health in the medical databases of PubMed and Embase databases found a total of 234 articles with only 18 studies met inclusion criteria. 

According to the identified studies, ingestion, topical use, and combined ingestion and topical use showed a statistically significant improvement in skin disease severity in the turmeric/curcumin treatment groups compared with control groups, including conditions of acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo.

Dr. Vaughn AR, the lead scientist after taking into account co and confounder wrote on the final report, "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health".

In order to reveal more information about curcumin in skin protection, researchers investigated the antioxidative, anti-inflammatory, and antibacterial properties against skin diseases.

According to the tested assays, curcumin exerted protective effects against skin damage caused by chronic ultraviolet B radiation.

Curcumin application also has a strong effect on the protection against skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer.

Taken altogether, turmeric may be considered a supplement for skin health with no side effect, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence by Vaughn AR1, Branum A2, Sivamani RK. (PubMed)
(2) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review by Panahi Y1, Fazlolahzadeh O2, Atkin SL3, Majeed M4, Butler AE5, Johnston TP6, Sahebkar A. (PubMed)

Herbal Bilberry Protects the Skin Against Allergic Contact Dermatitis.

By Kyle J. Norton


Contact dermatitis is a skin condition with symptoms of a red, itchy rash caused by direct contact with a substance or an immune overreaction against contact allergens.

Many chemicals and nonchemicals substances have been found to induce such abnormal reactions, including cosmetics, fragrances, jewelry, and plants.

Most cases of contact dermatitis are nonlife-threatening, however, the condition can induce certain discomforts, particularly in people with an allergic reaction to other conditions.

Contact dermatitis can be healed within a week or 2. The condition can be preventable if the cause is identified.

Besides the common symptoms of a red, itchy rash on the skin, some people may experience more serious symptoms including crusting swelling, burning or tenderness skin.

Dr. Imbesi S, the lead scientist in the explanation of the immune involvement of the allergic contact dermatitis wrote, " an inflammatory skin condition due to pro-inflammatory and toxic factors able to activate the skin innate immunity (irritant contact dermatitis) or caused by a T-cell- mediated hypersensitivity reaction (allergic contact dermatitis)".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency to find a natural ingredient for the treatment of chronic allergic contact dermatitis with no side effects, researchers examined the bilberry extract (Bilberon-25) in the alleviation of pruritus in a mouse model of chronic allergic contact dermatitis.

The study involved BALB/c mice with chronic allergic contact dermatitis induced by 3 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) following by the administration of Bilberon-25 orally for 3 weeks after sensitization with TNCB.

During the experiment, administered Bilberon-25 orally significantly attenuated the TNCB-induced increase in scratching behavior, compared to that of dexamethasone.

Both Bilberon-25 and dexamethasone inhibited the ear swelling.

Additional differentiation of the Bilberon-25 efficacy, the action of the herbal remedy inhibited symptoms of chronic allergic contact dermatitis by alleviating T helper cell type 2 (Th2) predominance of the lesional skin.

Based on the findings, researchers wrote in the final report, "Anthocyanins from bilberry might be beneficial for the treatment of chronic pruritus which can occur in patients with inflammatory skin diseases such as atopic dermatitis".

In order to reveal more information about anthocyanins activity against chronic allergic contact dermatitis, researchers at the Chiba Univ compared the anti-pruritic effect of anthocyanin-rich quality-controlled bilberry extract and anthocyanidin-rich degraded extract in a mouse model of allergic contact dermatitis.

Once again, BALB/c mice with allergic contact dermatitis induced by 4 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) following by administration of Bilberon-25 orally for 4 weeks.

Compared with nonheated Bilberon-25, the proportion of anthocyanins in heated Bilberon-25 decreased, and the proportion of anthocyanidins was increased in heated-time dependent manner.

Treatment with non-heated Bilberon-25 significantly attenuated the TNCB-induced increased scratching behavior, whereas treatment with 2 h-heated Bilberon-25 did not.

Particularly, 300 μg/mL nonheated Bilberon-25 showed significant inhibition of degranulation in RBL-2H3 mast cells.

The results suggested that the anthocyanin-rich but not anthocyanidin-rich bilberry extract inhibited the skin diseases involving pruritic symptoms, such as chronic allergic contact dermatitis, atopic dermatitis, and rhinitis.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the treatment of symptoms in patients with chronic allergic contact dermatitis, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis by Yamaura K1, Shimada M, Ueno K. (PubMed)
(2) Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation by Yamaura K1, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K. (PubMed)
(3) Allergic contact dermatitis: immune system involvement and distinctive clinical cases by Imbesi S1, Minciullo PL, Isola S, Gangemi S. (PubMed)

Herbal Turmeric Inhibits Parameters Associated with β-thalassemia

By Kyle J. Norton

Anemia is a health condition in which our body do not have enough red blood cells or less than the normal quantity of hemoglobin in the blood that carries the function of delivering oxygen and nutrient to the tissues.

Patients with Beta- thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.

 Beta thalassemia can be classified into 

* Thalassemia minor, the mild case of anemia. is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the loss of red blood cells.

* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in heart and other organs, resulting in heart failure.

Most common symptoms of beta thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.

If you have experienced persistently the aforementioned symptoms, please make sure that you check with your doctor for preventive measure.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural treatment of anemia, researchers examined the effects of curcumin, the active polyphenol in turmeric, on iron overload, hepcidin level, and liver function in β-thalassemia major patients.

The double-blind randomized controlled clinical trial was conducted on 68 β-thalassemia major patients, randomly divided into 2 groups to receive either 500 mg curcumin capsules (total: 1,000 mg) twice daily or placebo for 12 weeks.

Based on the observation of the tested assays, curcumin group showed a significant decrease in levels of nontransferrin bound iron (NTBI), aminotransferase (ALT) and Aspartate aminotransferase (AST) compared to the placebo group. 

In other words, turmeric protects the integrity of the red blood by reducing the cellular oxidative stress and inhibiting the iron toxicity in the β-thalassemia major patients without affecting the levels of hepcidin and other variables.

Based on the results, researchers wrote, " Curcumin administration alleviated the iron burden and liver dysfunction by reducing NTBI, ALT, and AST levels in patients with β-thalassemia major".

Additionally, according to the evaluation of the Mahidol University on 10 β-thalassemia/Hb E patients treated with 500 mg curcuminoids daily for 12 months, injection of the supplement showed significantly decreased intensity in thalassemic plasma, compared to those of normal subjects, including increased levels of plasma levels of proteins associated with the condition and reduced levels of oxidative damage.

More precisely, serum non-transferrin bound iron associated with iron overload, platelet factor-3 like activity, oxidative stress parameters and antioxidant enzymes were also improved after curcuminoids treatment.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of β-thalassemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial by Mohammadi E1, Tamaddoni A2, Qujeq D3, Nasseri E4, Zayeri F5, Zand H6, Gholami M7, Mir SM. (PubMed)
(2) Role of curcuminoids in ameliorating oxidative modification in β-thalassemia/Hb E plasma proteome by Weeraphan C1, Srisomsap C, Chokchaichamnankit D, Subhasitanont P, Hatairaktham S, Charoensakdi R, Panichkul N, Siritanaratkul N, Fucharoen S, Svasti J, Kalpravidh RW. (PubMed)

Bromelain Inhibits Knee Pain in Human Trials

By Kyle J. Norton

Knee pain or pain on the knee is a common complaint of people of all ages, particularly in the older population.

Causes of knee pain may be a result of ruptured ligament or torn cartilage and medical conditions such as arthritis, gout, and infections.

Acute knee pain is a condition that recovers itself in a short period of time.

Chronic knee pain is a medical condition that lasts more than 3 months. 

Compared to the acute knee pain, the most common causes of chronic knee pain are low-grade inflammation caused by repeated overuse or injury of the knee, that lead to damaged cartilage under the kneecap.

Chronic knee pain is also associated with patients with gout caused by the buildup of uric acid.

According to the statistics, approximately, 100 million Americans suffer from chronic pain. Knee pain is the second most common cause of chronic pain

In the gender perspective, between 15 and 20% of all men are afflicted with knee pain, compared to the overall prevalence of knee pain of roughly 20% in women.

Most common symptoms of knee pain are swelling and stiffness, particularly in the morning, redness and warmth to the touch, weakness, and instability and Inability to fully straighten the knee.

Conventionally, the immediate treatment for acute knee pain caused by occupation is rest, ice, and compression and pain relievers and anti-inflammatory drugs are prescribed to ease inflammation and pain.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for pain relief, researchers examined the effects of bromelain on patients with acute knee pain of fewer than 3 months duration in healthy adults.

Participants in the open, dose-ranging postal study were recruited through newspaper and magazine articles and received either 200 mg or 400 mg per day for one month.

According to the tested assays and questionnaire returned by 77 subjects who completed the study, both treatment groups showed a significant improvement of all WOMAC symptom dimension scores, particularly, in total symptom score.

Compared to the low dose intervention, treatment with 400 mg bromelain per day demonstrated a better of total symptom score (P = 0.036) and the stiffness (P = 0.026) and physical function (P = 0.021).

However, compared to the baseline, overall psychological well-being was significantly improved in both groups.

Based on the findings, researchers wrote, "We conclude that bromelain may be effective in ameliorating physical symptoms and improving general well-being in otherwise healthy adults suffering from mild knee pain in a dose-dependent manner".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute knee pain, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults by Walker AF1, Bundy R, Hicks SM, Middleton RW. (PubMed)