Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 16 May 2019

Herbal Ginger, A Potent Remedy for the Treatment Alzheimer's disease (AD) in Vivo

By Kyle J. Norton

Scientists may have found a natural aal ingredient used in every kitchen for the treatment of Alzheimer's disease (AD), according to studies.

Alzheimer's disease is a progressive disease caused the gradual loss of the neurons in the affected area.

People with AD experience of symptoms of memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. The severity of symptoms is totally depending on the stage of the disease.

Without proper treatment, Alzheimer's disease can get worse over time, and it is fatal.

According to the statistic, over 1 million people in the US alone are currently afflicted by Alzheimer's disease caused by the generation of the hippocampus and cerebral cortex of the brain where memory, language, and cognition located.

With this mental disorder, brain cells gradually die and generate fewer and fewer chemical signals day by day, leading to diminished functions.

As of today, there is no known cure. Most treatment is to interfere with the progression and improve the quality of the disease in people in the early stage.

Although there are many risk factor associated with the disease onset. However, in the examination of the median age of patients diagnosed with AD. Some researchers suggested that the increase in age may be one of the major risk factors that cause Alzheimer's disease.

Dr. Raymond Y. Lo, said, "Alzheimer's disease (AD) has become a global health issue as the population ages. There is no effective treatment to protect against its occurrence or progression. Some argue that the lack of treatment response is due to delays in diagnosis. By the time a diagnosis of AD is made, neurodegenerative changes are at the stage where very few neurons can be salvaged by medication".

And, " The paradigm of dementia care policy may shift to early diagnosis of AD pathology and comprehensive care for chronic diseases in the elderly population".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) with no side effects investigated the methanolic extract of dry ginger (GE) anti AD through the antioxidant activity, cholinesterase inhibition, anti-amyloidogenic potential, and neuroprotective properties.

The extracts used for the study included18 +/- 0.6 mg/g gallic acid equivalents of total phenolic content and 4.18 +/- 0.69 mg quercetin equivalents/g of dry material.

GE expressed high antioxidant activity with an IC50 value of 70 +/- 0.304 microg/mL, through reducing the expression of neuro oxidative stress in the initiation of AD.

According to the Ellman's assay, GE had an IC50 value of 41 +/- 1.2 microg/mL and 52 +/- 2 microg/mL for inhibition of acetyl- and butyrylcholinesterase association with the formation of β-amyloid (Aβ) plaques, respectively.

Also, GE increased the cell survival against amyloid beta (Abeta) induced toxicity in primary adult rat hippocampal cell culture.

Furthermore, GE effectively prevented the formation of Abeta oligomers and dissociated the preformed oligomers.

Based on the results, Dr. Mathew M, the lead scientist said, "Methanolic GE influences multiple therapeutic molecular targets of AD".

In order to provide more information about the ginger anti incidence of AD, researchers assessed the ability of a traditional Chinese medicinal ginger root extract (GRE) to prevent behavioral dysfunction in the Alzheimer disease (AD) rat model.

Rat AD models used for the study were treated with a one-time intra-cerebroventricular injection of amyloid β-protein (Aβ) and continuous gavage of aluminum chloride every day for 4 weeks before GRE was administered intragastrically.

At day 35, The significant memory deficits were shorter in the group that received OP with a high dose of GRE (HG)(OP+HG) than in the groups that received OP with a low or moderate dose of GRE (LG, MG)(OP+LG, OP+MG).

High dose of GRE (HG)(OP+HG) injection also increased the expression of antioxidant enzymes produced by the host such as superoxide dismutase (SOD) and catalase (CAT) compared to the OP+HG groups (p<0.05).

Also, rat treated high dose of GRE (HG)(OP+HG) also showed reduced levels of pro-inflammatory cytokines and oxidative stress marker.

Dr. Zeng GF, the lead scientist wrote in the final report, "This experiment demonstrates that the administration of GRE reverses behavioral dysfunction and prevents AD-like symptoms in our rat model".

Take all together, ginger processed a high amount of bioactive compounds may be considered a function alternative for the prevention and treatment of AD, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) In vitro evaluation of anti-Alzheimer effects of dry ginger (Zingiber officinale Roscoe) extract by Mathew M, Subramanian S. (PubMed)
(1) Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats by Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. (PubMed)
(3) The borderland between normal aging and dementia by Raymond Y. Lo. (PMC)

Whole Food Tomato Protects Your Heart Against Cardiovascular Diseases,

By Kyle J. Norton

Cardiovascular disease is a group of conditions involved in blood vessels and heart.

In the Western world, most cases of CVD are related to a process called atherosclerosis, a condition associated with plagues build-up on the wall of arteries that reduces the oxygen-rich blood flow to the heart in facilitating the onset of heart disease and stroke, depending to the affected location.

Heart disease is the condition caused by the plaques disruption that has induced significant heart muscle damage, leading to heart disease associated with symptoms

* Leg cramps during walking

Leg cramps during walking might be an indication of heart disease caused by arteries in your leg being clogged up by cholesterol in the result of not enough oxygen being delivered to the cells in your leg. If this symptom persists, please consult with your doctor.

* Chest pain
Chest pain is caused by blood vessels in the heart temporarily being blocked up by inadequate oxygen supply to the heart muscle. The persistence of chest pain would be an early indication of heart diseases.

* Shortness of breath
Shortness of breath (dyspnea) is the major symptom of the left ventricular insufficiency. People with shortness of breath are four times more likely to die from a heart disease-related cause than individuals without any symptoms.

* Headaches
People see sparkling zigzag lines or loss of vision before a migraine attack may be at particular risk of future cardiovascular problems. Generally, headaches do not cause heart diseases but a sudden, explosive onset of great pain might be.

* Dizziness
Dizziness can have many causes including low blood count, low iron in the bloodstream and other blood disorders, dehydration, and viral illnesses. Since there are many different conditions that can produce these symptoms, anybody experiencing episodes of severe headaches or dizziness ought to be checked by your doctor.

* Palpitations
Palpitations is an extremely common symptom of heart disease. Palpitations are the skips in the heart beats and irregular heartbeats.

* Loss of consciousness
It is a common symptom, most people pass out at least once in their lives. However, sometimes loss of consciousness indicates a dangerous or even life-threatening condition such as heart disease so when the loss of consciousness occurs it is important to figure out the cause.

Stroke is a condition caused either by the reduced blood or rupture of a blood vessel depriving oxygen in the blood that induces the death of neurons.

Symptoms of a stroke attack can be

* Sudden trouble in standing
Sudden trouble in standing is an early symptom of stroke as a result of the circulation of blood that carries oxygen to the brain suddenly deplete caused by narrowing of arteries and high blood pressure.

* Dizziness and loss of balance
The brain coordinates information from the eyes, the inner ear, and the body's sense to maintain balance. If the cells of that part of the brain get damaged in the result of depleted oxygen will cause dizziness and loss of balance.

* Sudden confusion
Sudden onset of confusion means that something is potentially going wrong with the brain. Almost all conditions that affect the brain are life-threatening.

* Having trouble speaking and understanding
Having trouble speaking and understanding occurs when the brain cells in the area of the Broca, Wernicke and angular gyrus in the left hemisphere area begin to die.

*Sudden severe headaches
Headache is a condition of pain in the head, sometimes neck or upper back pain may also be affected. It ranks amongst the most common local pain complaints and may be frequent for many people but sudden severe headaches may be caused by an early symptom of stroke due to the rupture of a brain vessel or depletion of oxygen in some parts of the brain.

* Sudden trouble seeing
This may be an early indication of stroke when the oxygen in the blood supply to the part of the brain is suddenly interrupted, affecting the cells that control the vision area of the cerebral cortex in the brain.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of cardiovascular disease (CVD), researchers examined the effect of consuming tomato products and lycopene on markers of cardiovascular (CV) function.

By searching 3 databases including Medline, Web of science, and Scopus from inception to August 2016, researchers identified 21 fulfilled inclusion criteria included in the meta-analyses.

All publication showed that the interventions supplementing tomato were associated with significant reductions in LDL-cholesterol, production of proinflammatory cytokine I(L-6), and improvements in flow-mediated dilation (FMD).

Compared to tomato, lycopene supplementation reduced systolic-BP (-5.66 mmHg; p = 0.002) without affecting other outcomes significantly.

Based on the results, Dr. Cheng HM, the lead scientist wrote, "The available evidence on the effects of tomato products and lycopene supplementation on CV risk factors supports the view that increasing the intake of these has positive effects on blood lipids, blood pressure, and endothelial function".

In other words, tomatoes processed a potential effect in the inhibition of CVD developing.

In other to review more information about tomato and its bioactive compound lycopene anti CVD activity, researchers examined the clinical trials comparing the efficacy of lycopene supplements with tomato products on intermediate CVD risk factors.

According to the results from the clinical trial, consuming tomato-based foods as a first-line approach to cardiovascular health.

However, compared to the supplement lycopene in blood pressure management, tomato intake provided more favorable results on cardiovascular risk endpoints than did lycopene supplementation.

Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the prevention and treatment of CVD, pending to large sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis by Cheng HM1, Koutsidis G1, Lodge JK1, Ashor A2, Siervo M2, Lara J. (PubMed)
(2) Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors by Burton-Freeman B, Sesso HD. (PubMed)
(3) Heart Diseases- Causes, Symptoms, Types, Preventions & Treatments by Kyle J. Norton
(4) Stroke - Causes, Symptoms The Risk Factors, Types, Preventions and Treatments by Kyle J. Norton

Cucumber and Bioactive Compound Cucurbitacins, The Best Neuroprotective Agents

Kyle J. Norton

The central nervous system containing the brain and the spinal cord is the complex system of nerve tissues that controls the activities of the human body.

It is the center that controls our thoughts, the interpreter of our external environment, and the body movement.

Neuroprotection is an action, including the use of substances such as herbal medicines to protect our bain against the loss and death of neurons.

Believe it or not, diseases associated with CNS are including

* Brain and spinal cord trauma, a type of condition can lead paralysis to mood disorders, depending on the location of the injury.

*CNS Infections caused by micro-organisms and viruses can lead as is meningitis and malaria.

*Disease associated with neuro-degeneration, include Alzheimer's disease and Parkinson's disease.

* Diseases associated with birth defects include anencephaly.

* Brain tumors caused by abnormal cell growth in the brain or metastases by primary cancer from other tissues and organ.

* Autoimmune disorders caused by the immune system that attacks mistakenly the brain and spinal cord cells.

* Stroke caused the death of neuron due to the reduced blood supply to the brain.

However, out of many risk factors involved in the onset of neurodegenerative disease, some researchers suggested that the promotion of a high-fat diet may be the major culprit that causes the rise of the incidence in the Western world.

Dr. the lead scientist wrote, "This increase in glial responses was associated with increased plaque burden in the hippocampus. Interestingly, given recent studies highlighting the importance of TREM2 in microglia/monocytes in AD susceptibility and progression, B6 and APP/PS1 mice fed the western diet showed significant increases TREM2+ microglia/monocytes".

And, " Therefore, an increase in TREM2+ microglia/monocytes may underlie the increased risk from a western diet to age-related neurodegenerative diseases such as Alzheimer’s disease".

On finding a potential ingredient which processes neuroprotective effect researchers evaluated the protective effect of Cucumis melo var. flexuosus (C. Melo var. flexuosus) leaf extract on the brains of diabetic rats.

The study included dietetic male albino rats induced by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg bw).divided into 5 groups of 6 rats each, a normal control group and four diabetic groups.

Additionally, 3/4 other groups were treated with C. Melo var. flexuosus (cucumber) leaf extract at the doses of 30, 60 and 120 mg/kg bw for a period of 30 days compared to nontreatment of a diabetic group.

Compared to non treated diabetic rats, treated rat protected the brain neurons by markedly increasing the plasma dopamine, melatonin, brain vascular endothelial growth factor-A levels, particularly the antioxidant activity in the brain tissues.

In other words, cucumber leaf extract processes neuroprotective effect by preventing neurons oxidative damage associated with diabetes.

Based on the results, Dr. Ibrahim DS, at the Benha University wrote, " it can be concluded that the C. Melo var. flexuosus leaf extract exerts a neuroprotective effect against oxidative damage associated with diabetes".

In order to reveal more information about cucumber neuroprotective property, researchers examined the effect of Cucurbitacins (CuB), a major bioactive compound from cucumber on neuroinflammatory responses are involved in the neuronal injury.

According to the tested results, pretreatment with Cucurbitacins significantly reduced the production of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6 iNOS and COX-2 expression) in microglia, a type of neuroglia (glial cell) located throughout the brain and spinal cord.

Furthermore, CuB also inhibited the proteins and pathways associated with the stimulation of immune response in the activated production of inflammation.

Moreover, the neuroprotective of CuB was also attributed to the bioactive compound in the activation of (Nrf2/ARE pathway) pathways involved in significantly greater resistance to oxidative stress and protein associated with the production of antioxidants and anti-inflammatory cytokines.

Dr. Park SY, the lead scientist said, "Cucurbitacins is a potent activator of the Nrf2/ARE pathway and is therapeutically relevant not only to neuroinflammatory responses of microglia but also neuroinflammation mediated neuronal injury".

Taken altogether, cucumber processed high levels of CuB may be considered a neuroprotective remedy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Neuroprotective effect of Cucumis melo Var. flexuosus leaf extract on the brains of rats with streptozotocin-induced diabetes by Ibrahim DS. (PubMed)
(2) Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition by Park SY1, Kim YH1, Park G2. (PubMed)
(3) Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease by Leah C. Graham,1,2 Jeffrey M. Harder,1 Ileana Soto,1 Wilhelmine N. de Vries,1,3Simon W. M. John,1,2,3,4 and Gareth R. Howella. (PMC)

Phytochemical Betanin, a Natural Plant-Based Antioxidant that Prevents Oxidative Stress Developing

By Kyle J. Norton

Oxidative stress is a condition caused by an imbalance of the ratio of free radical and antioxidant in the body.

In other words, oxidative stress is either caused by overexpression of free radical or depletion of antioxidant enzymes in the body.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Long-term oxidative stress presented in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.

More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.

The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".

In other words, oxidative stress may be preventable by following a diet with rich in antioxidants such as a diet with higher fruits and vegetable consumption accompanied by moderate exercise and reducing intake of saturated and trans fat and processed foods.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the prevention of diseases associated with oxidative stress, researchers examined the effects of natural pigment betanin on oxidative stress in the kidney of paraquat-treated rat.

Paraquat injected intraperitoneally induce renal damage rats were randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.

Betanin treated rats showed strong activity in alleviating the paraquat-incurred acute kidney injury, observed by the improvement, reduced serum and urine markers that indicate a kidney injury.

Betanin also decreased oxidative stress elicited by paraquat by increasing the expression of antioxidant enzymes produced by the host accompanied by inhibiting the levels of free radicals.

These results suggested that betanin protects the tested rats against kidney damage due to oxidative stress in the induction of chronic inflammation.

In streptozotocin (STZ) induced diabetes (DN) in rats, researchers examined the betanin anti-fibrotic mechanisms in rat kidney.

Betanin at a dose of 25, 50 and 100mg/kg/day and lisinopril (5mg/kg/day, reference compound) orally administered for 8 weeks after the induction of DN, not only significantly inhibited proteinuria, blood glucose, serum creatinine and blood urea nitrogen (BUN) levels involved in kidney injury, but also restored antioxidant enzyme activities in kidney tissue.

Additionally, betanin treatment also protected the kidney integrity by reducing the glomerular surface area, glomerulosclerosis and tubulointerstitial fibrosis.

In other words, betanin demonstrated the kidney protective activity against streptozotocin (STZ) induced diabetes (DN) in rats through regulation of transforming growth factor beta (TGF-β) in facilitating anti-oxidative and anti-inflammatory activity.

Taken altogether, betanin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2.(PubMed)
(3) Oxidative Stress, From Liver Pathophysiology, 2017. (Science Direct)

Wednesday, 15 May 2019

Herbal Turmeric Protects the Stomach Against Gastritis Developing

By Kyle J. Norton

Gastritis is a group of conditions associated with the inflammation of the lining of the stomach caused by infection of the bacterium, leading stomach ulcers developing.

A stomach ulcer is an open sore in the lining of the stomach. In most cases, it is a result of bacterial infection that leads to the erosion of the gastric lining by stomach acid.

Other causes of gastritis are long term excessive alcohol consumption and use of certain medication such as aspirin.

There are 2 types of gastritis
* Acute gastritis occurs suddenly as a result of inflammation or swelling in the lining of the stomach. and only affects the stomach and induce nausea or vomiting,

* Chronic gastritis is a condition that develops slowly due to chronic inflammation or damage of stomach lining that has not healed.

Patients with chronic gastritis if untreated were found to have a substantial risk of stomach cancer.
Most common symptoms of gastritis are burning sensation or pain in the upper abdomen, nausea, vomiting and abnormal feeling of fullness in the upper abdomen after eating.

Out of many risk factors involved in the onset of the condition, some researchers in the observation of the correlation of high-fat diet induced obesity over the past few decades, in the risk of gastritis wrote, "Obesity has become a major concern among gastroenterologists due to its large influence on gastrointestinal and hepatic diseases: reflux esophagitis, pancreatitis, gallstone disease, liver fibrosis, and neoplastic tumors of the esophagus, pancreas, and colon".

And, "the effects of obesity on endoscopic gastritis in subjects undergoing health check-up examination, and demonstrated that adiponectin, a bioactive molecule released from visceral fat, could be a protective factor of endoscopic gastritis".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of gastric inflammation, researchers examined the effect of diterpenoid C extracted from radix curcumae on Helicobacter pylori (H. pylori)-infected inflammation, intestinal metaplasia.

The study included human gastric epithelial gastric epithelium cell line (GES-1) infected by I-type H. pylori treated with radix curcumae (RC)-derived diterpenoid C of different concentrations (5, 10, 20 μg/mL) and amoxicillin.

According to the MTT assay, IC5 of RC-derived diterpenoid C and amoxicillin of 5 μg/mL inhibited the progression rate of GES-1.

The combination also inhibited the production of pro-inflammatory cytokines and exhibited the production of anti-inflammatory cytokines associated with injection of I-type H. pylori in the GES-1,
particularly, at 12, 24, 48, 72 h points.

In other words, the combination protecting the stomach against gastric inflammation by blocking the activation of a protein involved in the stimulation of pro-inflammatory cytokines.

Based on the findings, researchers wrote, "RC-derived diterpenoid C can block NF-κB signal pathway, effectively reducing the secretion of H. pylori-induced proinflammatory cytokine and increasing the secretion of anti-inflammatory cytokine".

In Helicobacter pylori infection of the lining of the stomach induces an array of inflammatory cytokine production that leads to gastritis and peptic ulcer disease, researchers at the Uttaradit Hospital conducted an experiment to to investigate the effect of curcumin on the production of interleukin (IL)-8, IL-1beta, tumor necrosis factor (TNF)-alpha and cyclooxygenase (COX)-2 in gastric mucosa from H. pylori-infected gastritis patients.

Selected patients were randomly assigned to receive either OAM (Omeprazole, Amoxicillin, and Metronidazole) treatment and/or a course of curcumin.

According to the tested assays, curcumin alone may have a limited anti-bactericidal effect on H. pylori, and on the production of inflammatory cytokines compared to those of the OAM group.

However, curcumin group showed significant relieving symptoms with a lower rate in the eradication rate of H. pylori and no decreased cytokine production.

Precisely, curcumin used alone has limit efficacy compared to that of the combination in reducing the gastric inflammation.

Taken altogether, turmeric processed abundant bioactive ingredient curcumin may be combined with other conventional medicines for the prevention and treatment of gastric inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways by Huang X1, Lv B, Zhang S, Dai Q, Chen BB, Meng LN. (PubMed)
(2) Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients by Koosirirat C1, Linpisarn S, Changsom D, Chawansuntati K, Wipasa J. (PubMed)
(3) Is obesity a new risk factor for gastritis? by Yamamoto S1, Watabe K, Takehara T. (PubMed)

Whole Food Ginger, the Best Functional Food to Protect Yourself Against Radiation

By Kyle J. Norton

Scientists may have found a kitchen spice for the inhibition of the side effects induced by radiation, according to studies.

Radiation is a technique used to emit energy in the form of waves or particles through space or through a medium. In medical, using radiation is a type of diagnosis and treatment to detect and treat certain medical conditions such as hyperthyroidism and bone cancer.

However, exposure to such radiation has been found to have a negative impact on human health, including acute health effects such as skin burns and radiation syndrome.

Most cases of low levels of radiation exposure in the environment do not cause immediate health effects but it has been found to contribute to our overall cancer risk, including X-ray.

Long-term exposure is associated with cancer and cardiovascular disease.

Dr. Ananya Mandal, MD, in the article "Radiation Exposure Prevention" wrote, "Increasing the distance of an individual from the source of radiation can, therefore, reduce the dose of radiation they are exposed to... The time spent exposed to radiation should be limited as much as possible. The longer an individual is subjected to radiation, the larger the dose from the source will be".

And, "Potassium iodide (KI) can be given orally immediately after exposure to radiation. This helps protect the thyroid from the effects of ingesting radioactive iodine if an accident occurs at a nuclear power plant... Shielding refers to the use of absorbent material to cover a reactor or other source of radiation so that less radiation is emitted in the environment where humans may be exposed to it".

In short, you can protect yourselves from radiation, by increasing distance from the radiation site, limiting the time exposure, shielding yourself from the exposure and taking potassium iodide (KI).

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers in the concerns about the use of ionizing radiation compromised by the side effects that result from radiation-induced damage to normal tissue investigated ginger radiation protective property.

In vitro, ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae) and its phytochemicals dehydrozingerone, zingerone have shown to possess radioprotective effects in laboratory animals and in cultured cells.

Furthermore, injection of the hydroalcoholic extract of ginger rhizome administered either through intraperitoneal or oral route was effective in protecting against gamma radiation-induced sickness and mortality.

In an animal study, the phytochemicals dehydrogingerone and zingerone present in ginger are also shown to protect mice against radiation-induced sickness and mortality.

In tumor-bearing mice, ginger has also shown that zingerone selectively protects the normal tissues against the tumoricidal effects of radiation.

Mechanistically, the efficacy of ginger against radiation was attributed to the free radical scavenging, antioxidant effects, anti-inflammatory, and estrogenic effects.

In order to know more information about ginger anti-radiation activity, researchers Kasturba Medical College examined the radioprotective effect of the hydroalcoholic extract of ginger rhizome.

The study included mice given 10 mg/kg ZOE intraperitoneally once daily for five consecutive days before exposure to 6-12 Gy of gamma radiation and monitored daily up to 30 days postirradiation for the development of symptoms of radiation sickness and mortality.

During the experiment, pretreatment of ZOE mice reduced the severity of radiation sickness and the mortality at all doses.

The ZOE treatment protected mice from GI syndrome as well as bone marrow syndrome with the optimum protective dose of 10 mg/kg ZOE was 1/50 of the LD50 (500 mg/kg).

Radiation-induced lipid peroxidation and depletion of GSH on day 31 are also reduced by the injection ZOE.

Take all together, ginger may be considered a functional alternative for prevention and treatment of acute radiation side effects, pending to the confirmation of large sample size and multicenter human study.

Radiation
(1) Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future by Baliga MS1, Haniadka R, Pereira MM, Thilakchand KR, Rao S, Arora R. (PubMed)
(2) Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation by Jagetia GC1, Baliga MS, Venkatesh P, Ulloor JN. (PubMed)
(3) Radiation Exposure Prevention by Dr. Ananya Mandal, MD (News, Medical Life sciences)

Phytochemical 3,3'-Diindolylmethane, Protects Your Bone Against Osteoporosis

By Kyle J. Norton

Osteoporosis is a medical condition characterized by loss of bone density over time, caused by overexpression of bone loss compared to bone made.

In other words, osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time, leading to an increased risk of fracture.

Most common fractures occurred in patients with OP are the hip, spine, wrist, and shoulder.
Most people with a risk of fracture do not know they have osteoporosis until the disease has advanced to the advanced stage.

Researchers do not know the exact causes of osteoporosis. Neither they know why some people with the same health condition in the same family, some are prone to the condition, while others do not.

However, according to the epidemiological studies, young age at diagnosis, male sex, aging, race, family history, body size, decreased lean mass, smoking and use of growth hormone replacement are some of the prevalent factors found in most patients with osteoporosis.

Most common symptoms of osteoporosis are lost of height over time, back pain, a stooped posture, neck, and low back pain, particularly bone break easily.

Recently, some scientists suggested that osteoporosis may also be associated with long term consumption of a poor diet.

Dr. Seon-Joo Park in the investigation of dietary patterns and osteoporosis risk wrote, "Three major dietary patterns were identified using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread)".

And, ".., Western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".

These results strongly suggested if you are Western diet follower, your risk of osteoporosis is increased substantially compared to other healthy diet pattern followers.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding the natural compound for the treatment of osteoporosis, researchers investigated the effect DIM on bone mass in mice under physiological and pathological conditions.

The study included 8-week-old female mice received injections of a vehicle or 0.1mg/g of DIM, twice a week for four weeks.

According to the dual-energy X-ray absorptiometry (DEXA) and micro-computed tomography (μCT) analysis, DIM treatment significantly increased bone mass.

Interestingly, treatment od DIM was found to significantly reduce bone resorption parameters but did not increase bone formation parameters.

In ovariectomized (OVX)-induced osteoporotic mouse model, administration of DIM effectively prevented OVX-induced bone loss resulting from increased bone resorption.

In other words, DIM increased bone mass by suppressing osteoclastic bone resorption in bone metabolism under both physiological and pathological conditions.

The results strongly suggested that DIM protect the bone integrity against the onset of osteoporosis in vivo and vitro.

Dr. Yu TY, the lead researcher, after taking other factors into account said, "DIM may be of value in the treatment and the possible prevention of bone diseases characterized by bone loss, such as postmenopausal osteoporosis".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic boneresorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PubMed)