Phytochemical 3,3'-Diindolylmethane kills Gastrointestinal Cancer Cells In Vivo and Vitro

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of gastrointestinal cancer with no side effects, according to studies.

Gastrointestinal (GI) cancer is a group of cancers, affecting the digestive system, including esophagus, gallbladder & biliary tract, liver, pancreas, stomach, small intestine, bowel, and anus

The digestive system consists of the gastrointestinal tract and other parts of the accessory organs of digestion including the tongue, salivary glands, pancreas, liver, and gallbladder), involved in the function of breaking down food into smaller and smaller components then absorbed before passing them as nutrients and fluids to the body.

Most cases of gastrointestinal cancer start in the cells on the surface of the inner lining tissues, depending on the location of the affected organs.

At the early stage, most patients are asymptomatic due to the small size of the tumor. However, at the later stage, after penetrating into deeper layers of the organ, cancer cells can travel through blood and fluids circulation to infect other healthy tissues or organs, leading to secondary metastasis.

At this stage, besides sharing the general symptoms of other types of cancer, gastrointestinal cancer also cause symptoms of severe pain and bleeding due to the overgrowth tumor size have suppressed the nearby blood vessels and nerve cells.

The exact causes of gastrointestinal cancer are not identified. However, genetic preposition, unhealthy lifestyle and medical conditions are some of the prevalent risks of the disease.

Some researchers suggested that a poor diet may have a strong implication on the incidence of gastrointestinal cancer.

Dr. Reilly T. Enos, the leads scientist said, "High-fat-diet (HFD) consumption is associated with colon cancer risk".

And, "HFDs with the highest SF content had the greatest concentration of Muc2. Our data suggest that high dietary SF is protective in the AOM/DSS model of colon cancer, which may be due, at least in part, to the ability of SF to maintain intestinal barrier integrity through increased colonic Muc2".

With an aim to find a natural compound for the treatment of gastrointestinal cancers, researchers examined the 3,3'-Diindolylmethane (DIM) activity against effective gastrointestinal cancers.

In vivo and vitro, injection of the DIM acted upon several cellular and molecular processes in gastrointestinal cancer cells.

In cancer cells apoptosis, DIM  initiated production reactive oxygen species (ROS) in generating stress, triggering DNA damage by increasing the cytotoxicity.

In angiogenesis, DIM inhibited the protein associated with the generation of a new blood vessel for cells survival and proliferation.

In cell cycle regulation, DIM deactivated the expression of protein kinases which play the critical roles in the cancer cells division.

Furthermore, DIM triggers cellular endoplasmic reticulum (ER) stress and apoptosis within the cancer cells.

In autophagy, DIM inhibited autophagy that leads to cell death.

In metastasis, DIM  inhibited the growth of human cancer cells by interfering with multiple signaling pathways, involved restraining invasion, migration, and promoting apoptosis.

Furthermore, DIM used combined with conventional chemo drugs or therapeutic chemicals increased the efficacy of other drugs for the treatment of gastrointestinal cancer.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of gastrointestinal cancers, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer by Kim SM. (PubMed)

Herbal Artichoke Promotes Healthy Levels of Free Fatty Acids

By Kyle J. Norton


Free fatty acids found in fats and oils and in cell membranes are the by-products produced in the metabolism of fat in adipose tissues.

In other words, free fatty acids are produced by breaking down fats into fatty acids, which can then be absorbed into the blood.

Fatty acids can be used as fuel for the cells if glucose is not available for energy.

Free fatty acids play a critical role in the maintenance of our body functioning, including
* Cell signaling through the formation of the of eicosanoids, a group of signaling molecules involved in the immune response.

* In metabolism, FFAs play essential roles in the regulation of energy metabolism and mediation of a wide range of metabolic processes.

* In cells, FFAs are used for the formation of cell membrane or wall.

* More importantly, FFAs also have a strong effect on the endothelial function and dysfunction.

Dr. Carmen Gonzalez, the lead scientist in the examination of the role of free fatty acids wrote, "FFARs have been targeted in drug development for the treatment of type 2 diabetes and metabolic syndrome. FFAs upregulate transcription of uncoupling proteins, increasing their expression in brain, cardiac, and skeletal muscle that may be protective or cytotoxic, depending on the cellular energy state".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belongings to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

With an aim to find a natural ingredient for the improvement of healthy levels of free fatty acids (FFAs) in human, researchers examined the artichoke bracts (AB) in an animal model.

The study included a total of 120 rabbits aged 38 days divided into three groups fed with different isonitrogenous and isocaloric diets supplemented with AB at 0%, 5%, and 10%.

At 96 days of age, after observing the carcasses of 12 rabbits slaughtered in an experimental slaughterhouse without fasting, researchers found that the levels of α-linolenic acid proportion were decreased with the injection of AB supplementation from 3.58% to 2.59% in the LD muscle and from 4.74% to 3.62% in the perirenal fat.

Furthermore, the meat ether extract (FFAs) content also was increased from 0.68% to 0.94% on fresh matter basis by the injection of AB supplementation.

The levels of n-6/n-3 ratio increased significantly with increasing AB inclusion from 7.15 to 10.20 in the LD muscle and from 6.68 to 9.35 in the perirenal fat.

The results suggested that artichoke has a strong impact on improving quality and fatty acid composition.

Moreover, in order to reveal additional information about artichoke on fatty acids, researchers launched an investigation of Nigella sativa, lupin and artichoke seed oils' fatty acids (FA, as methyl esters) using gas chromatographic analysis (GLC).

At the end of the experiment, researchers found that three seed oils are rich in FFAs including oleic and linoleic acid content.

According to the results from the high-pressure liquid chromatography (HPLC) assay, artichoke oil was unique in having a high content of 5-stigma-, 7-stigma-, and avenasterol compared to those of Nigella sativa, Lupin, particularly in levels of FSG and ASG.

The findings lead us to say that artichoke seed oil can be recommended as healthy oils and folk medicine, according to Dr. M Hassanein MM, the lead scientist at the National Research Centre, Fats, and Oils Dept, Egypt.

Taken altogether, artichoke (seed oils) may be considered a healthy choice of free fatty acids for reducing the risk of diseases associated with high blood pressure, insulin resistance, high triglycerides, and low “good” HDL cholesterol levels, pending to the validation of larger sample size and multicenter human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Dried artichoke bracts in rabbits nutrition: effects on the carcass characteristics, meat quality and fatty-acid composition by Dabbou S1, Gasco L1, Gai F2, Zoccarato I1, Rotolo L1, Dabbou Fekih S3, Brugiapaglia A1, Helal AN3, Peiretti PG. (PubMed)
(2) Investigation of lipids profiles of Nigella, lupin and artichoke seed oils to be used as healthy oils by M Hassanein MM1, El-Shami SM, El-Mallah MH. (PubMed)
(3) Role of Free Fatty Acids in Physiological Conditions and Mitochondrial Dysfunction by Zbigniew K. Binienda, Sumit Sarkar, Sonia Silva-Ramirez, Carmen Gonzalez. (Scientific Research)

Plant-Based 3,3'-Diindolylmethane (DIM), the Best for the Treatment of Radiation Induced Intestinal Injury in Vivo

By Kyle J. Norton


Intestinal injury of small bowel, colon, or rectum can be due to blunt or penetrating trauma, and irradiation.

Intestinal injury can be minor which can be healed by its own or devascularization for blunt injuries and small perforations which may require surgery.

Most common symptoms of intestinal injury are totally depending on the severity of the damage, including abdominal tenderness or distention, mild, moderate or severe abdominal pain,  forceful bowel movements, the urge to have a bowel movement.

Patients may also experience symptoms of blood in the stool and mental confusion.

If you have some of the aforementioned symptoms, please see your doctor immediately.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding a natural compound for the treatment of intestinal injury, researchers examined 3,3'-Diindolylmethane (DIM), a potent antioxidant agent in the amelioration of hematopoietic injury in a murine model of total body radiation injury.

In abdominal irradiation-induced intestinal injury in mice, administration of DIM ameliorated crypt-villus structural and functional injury of the small intestine.

DIM also protected the mice against whole abdominal irradiation (WAI)-induced lethality and weight loss. 

Furthermore, MIC was found to promote the small intestine repair following WAI exposure.

MIC protected the intestinal cell against apoptosis caused by the injection of WAI by stimulating the production of proteins which protect the cells against oxidative damage triggered by injury and inflammation. 

In other words, DIM protected human intestinal epithelial cell-6 (HIEC-6) against ionizing radiation, leading to increase cell vitality by protecting the cell DNA against damage caused by radiation.

The efficacy of the protective activity in the depth analysis was found to associate with the reduction of reactive oxygen species (ROS) levels and promotion of the production of antioxidant enzymatic in tested HIEC-6 cells.

Based on the results, researchers suggested DIM restores the WAI-shifted gut bacteria composition in mice in the exhibition of intestinal injury.

Dr. the lead scientists after taking other factors into accounts said, "the beneficial properties of DIM mitigate intestinal radiation injury, which provides a novel strategy for improving the therapeutic effects of irradiation-induced intestinal injury".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection and treatment of intestinal injury, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Amelioration of whole abdominal irradiation-induced intestinal injury in mice with 3,3'-Diindolylmethane (DIM) by Lu L1, Jiang M2, Zhu C2, He J2, Fan S. (PubMed)

Herbal Artichoke Modulates the Glycemic Responses Against Elevated Level of Glucose After A Meal

By Kyle J. Norton


Glycemic response is a change in blood glucose after consuming a carbohydrate-containing food compared to Glycemic Index (GI) which is a ranking of carbohydrate-containing foods according to their effect on blood glucose levels.

Some researchers suggested that the glycemic response is the change of blood glucose after the intake of a food or meal.

Most healthy individual has normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period of time.

According to the epidemiological studies, by controlling the glycaemic response with the healthy range, the glycaemic response can reduce the risk of type 2 diabetes.

Including additional fiber into a meal or food may have a strong implication in reducing the levels of glucose shortly after intake.

Dr. Jenkins DJ, the lead scientists in the examination of adding fiber into a meal effect in glycemic response wrote, "Addition of purified fiber to carbohydrate test meals has been shown to flatten the glycemic response in both normal and diabetic volunteers, reduce the insulin requirement in patients on the artificial pancreas and in the longer term reduce urinary glucose loss and improve diabetes control".

And, " More recently it has become clear that many aspects of carbohydrate foods (food form, antinutrients, etc.) in addition to fiber may influence the rate of digestion and has led to a classification especially of starchy foods in terms of glycemic index to define the degree to which equicarbohydrate portions of different foods raise the blood glucose".

The results strongly suggested people with abnormal levels of glycemic responses should always add some fiber to their diet to prevent the fluctuation of blood glucose before and after a meal.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutic for the control of postprandial glycemic responses investigated the extracts from Phaseolus vulgaris and Cynara scolymus and their 1:2 combination effect on postprandial glycemia after food intake.

The study included rats given access to regular food and water, regular food, water, and a chocolate-flavored beverage, or infused with a starch bolus.

According to test assays, injection of P. vulgaris extract and the combination produced comparable reductions in intake of regular food and chocolate-flavored beverage.

Furthermore, P. vulgaris and C. scolymus extracts additively contributed to the reduction of the glycemic rise.

The finding suggested that the combination is more favorable over single extract for the treatment of postprandial glycemic responses.

Dr. the lead scientist after taking into account co and confounders said, " recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia".

Taken altogether, artichoke combined with kidney bean may be considered a functional formula for the treatment of patients with elevated postprandial glycemic responses with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymusextracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA. (PubMed)
(2) Dietary fiber and the glycemic response by Jenkins DJ, Jenkins AL. (PubMed)

Herbal Bilberry Protects Your Gum Against Gingival Inflammation.

By Kyle J. Norton


Gingivitis or gingival inflammation is a condition of inflammation of the gum caused by overexpression of plaques accumulated on your teeth that irritate the gingiva. Over times, the gum of infected person has become swollen and bleed easily.

In severe cases, the condition can lead to periodontal disease, inducing tooth decay or loss of the tooth.

Most of the cases of gingivitis are associated with poor hygiene, particularly in people who smoke.

Patients can reverse gingivitis if they follow a good oral health habit, including brushing at least twice a day, flossing daily and getting regular dental checkups.

Most common symptoms of gingivitis including swollen gums with dusky red or dark red color and bleeding easily when brush or floss, particularly breath-breath. 

According to the statistics provided by the CDC, smoking is an important cause of severe gum disease in the US.

Dr. Fouad H. Al-Bayaty, the lead scientist in the study of "The Influence of Cigarette Smoking on Gingival Bleeding and Serum Concentrations of Haptoglobin and Alpha 1-Antitrypsin" wrote,
"Duration of smoking (years) and the cotinine level in serum showed a significant correlation with plaque index. The present analysis demonstrated that the duration of smoking in years, but not the number of cigarettes smoked per day, was associated with reduced gingival bleeding in smokers".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a natural source for the treatment of gingival inflammation, researchers investigated the effect of bilberry consumption on the outcome of routine dental clinical parameters such as inflammation, bleeding on probing (BOP)and biomarkers of inflammation.

The study included individuals who did not receive standard of care treatment allocated to either a placebo group or to groups that consumed either 250 or 500 g bilberries daily over seven days compared to placebo group consumed an inactive product (starch).

During the study, The mean of the groups that consumed either 250 or 500 g of bilberries/day showed a reduction in BOP before and after consumption of test product over 1 week was 41% and 59% compared to 31% in the placebo group, and 58% in the standard of care reference group.

The group that consumed 500 g of bilberries/day also showed a significant reduction of the pro-inflammatory cytokine levels compared to consumed 250 g of bilberries/day group.

The results strongly suggested that bilberry inhibited proinflammatory proteins linearly in dose dependent-manner observed by the reduction of levels of IL-1b, IL-6, and VEGF.

Based on the findings, researchers wrote, " It appears that berry intake has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care".

Taken altogether, bilberry may be considered a functioning remedy for the treatment of gingival inflammation, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Consumption of bilberries controls gingival inflammation by Widén C1, Coleman M2, Critén S3, Karlgren-Andersson P4, Renvert S5,6,7, Persson GR. (PubMed)
(2) The Influence of Cigarette Smoking on Gingival Bleeding and Serum Concentrations of Haptoglobin and Alpha 1-Antitrypsin by Fouad H. Al-Bayaty,1 NorAdinar Baharuddin,2 Mahmood A. Abdulla,3 Hapipah Mohd Ali,4 Magaji B. Arkilla,5 and Mustafa F. ALBayaty. (Hindawi)

Herbal Ginger, the Natural and Effective Treatment of Menorrhagia ( Heavy Menstrual Bleeding) with No Side Effects in Human Studies

By Kyle J. Norton

Scientists may have found a kitchen pungent spice for the treatment for women with the condition of excessive menstrual bleeding during menstruation with no side effects, according to studies.

Menorrhagia is a condition of excessive bleeding in the menstruation phase of the menstrual cycle in the reproductive age woman, caused by the disruption of normal hormonal regulation of periods or disorders of certain reproductive organs.

The heavy loss of blood has been found to interfere with the woman daily normal activities.

In traditional Chinese medicine, menorrhagia can be caused by a combination of spleen qi deficiency, liver blood deficiency, damp accumulation.

Depending on the differentiation, treatments may include tonifying spleen qi, nourishing the blood, and/or resolving dampness. 

In TCM, the same disease can be treated with different formula and difference diseases may be treated with the same formula, depending on the diagnosis.

Similar to those of dysmenorrhea,, menorrhagia also can be classified into 2 types

* Primary menorrhagia is the heavy menstrual bleeding disorder with no underlined causes.

* Secondary menorrhagia is the heavy menstrual bleeding disorder due to damage of reproductive organs such as adenomyosis, dysfunction of the ovaries, and uterine fibroids.

Aging is one of the most common causes of menorrhagia. Women who are at the age of 40 - 50 may be experience abnormal menstrual cramps and pain and heavy than a normal period as a result of approaching the menopause stage. 

And, girls in their first 2 years of menstruation may experience the adnominal cramp and pain and heavy period due to the immature of the reproductive organs. 

Conventionally, most cases of menorrhagia are treated with ethamsylate, non-steroidal anti-inflammatory drugs (NSAIDs) and birth control.

If you are currently taking one of the aforementioned drugs, please make sure you know all the side effects for preventive measure.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of the heavy menstrual bleeding disorder, with no side effects, evaluated the effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) as complementary treatments for heavy menstrual bleeding (HMB) among women of reproductive age.

The randomized, placebo-controlled, clinical trial based on the data provided by the gynecology outpatient clinics included patients with HMB (n = 102) randomly assigned to three groups.

All patients received ibuprofen (200 mg) and either frankincense (300 mg), ginger (300 mg), or a placebo.

According to the assays, ginger exerted a significant effect in reduced the duration of menstrual bleeding similar to those of frankincense group, compared to no reduction in the placebo group.

Ginger and frankincense groups showed a statistically significant improvement of the QOL compared to the placebo group.

Dr. the lead scientist said, "Ginger and frankincense seem to be effective complementary treatments for HMB".

Furthermore, in order to reveal more information about ginger effects on HMB, researchers at the Iran University of Medical Sciences investigated the effect of ginger (Zingiber officinale) in high school girls.

The study included 92 young women who experienced HMB were evaluated for six consecutive menstrual cycles and randomly allocated to two study groups to receive either ginger or placebo capsules.

According to the assessment, the ginger-receiving group displayed a reduction in the level of menstrual blood loss dramatically during the three intervention cycles.

The decrease of blood loss in the ginger-receiving group was significant and remarkable compared to that of participants receiving a placebo.

Adverse effects were reported by a minimum number of participants.

Take all together, ginger may be considered a functional alternative for the prevention and treatment of the heavy menstrual bleeding disorder, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial by Kashefi F1, Khajehei M, Alavinia M, Golmakani E, Asili J.(PubMed)
(2) The effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) on heavy menstrual bleeding: A randomized, placebo-controlled, clinical trial by Eshaghian R1, Mazaheri M2, Ghanadian M3, Rouholamin S4, Feizi A5, Babaeian M. (PubMed)

Topical Turmeric, the Best for the Prevention and Treatment Vitiligo

By Kyle J. Norton

Vitiligo is a condition of skin discolor disease caused by the destruction of pigment cells and melanocytes of the skin.

The condition in most cases is localized. However, in some patients, the disease also can affect several different areas on the body.

Symptoms of vitiligo are associated with the loss of skin color, or white, and patches of skin.

The exact cause of vitiligo is unknown, however, some researchers suggested that the disease may be caused by the immune overreaction that mistakenly attacks and destroys certain cells within the body.

Epidemiologically, people in the younger age group before the age of 40 are at most risk of vitiligo.

According to the statistics, over 50% of vitiligo are found in patients who are 20 and younger.

The condition has been found to induce emotional and psychological issues to patients, even the condition does not cause pain or health problems.

As of today, researchers do not know how to prevent disease onset. Most medications for the treatment of vitiligo including creams that control inflammation, combining psoralen and light therapy are focusing on reducing the severity of the condition and improve the quality of life.

If all noninvasive treatments fail, surgery may be necessary.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of vitiligo, researchers examined the curcumin effect on the pigment cells of the skin, melanocytes.

Injection of Cucumis melo extract showed to exhibit the production of antioxidant by the host in blocking the effect of free radical in the induction of skin oxidative stress.

Topical preparation, containing Cucumis melo superoxide dismutase (SOD) and catalase, demonstrated a potential effect in the treatment of vitiligo.

Natural UV or artificial narrowband UVB treatment or phototherapy displayed significant protection against pigment damage, similar to those of turmeric topical preparation.

Additionally, the topical gel according to the repigmentation rate recorded exerted a similar effect compared to the patients treated only with the phototherapy with adverse effects.

Moreover, the topical formulation, containing phenylalanine, Cucumis melo extract, and acetylcysteine showed a more promising result combined with nb - UVB target phototherapy.


Based on the findings, turmeric used along with or combined with other conventional medicine may be considered remedies for the prevention and treatment of vitiligo pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Herbal Compounds for the Treatment of Vitiligo: A Review by Serena Gianfaldoni,1,* Uwe Wollina,2 Michael Tirant,3 Georgi Tchernev,4 Jacopo Lotti,5Francesca Satolli,6 Miriam Rovesti,6 Katlein França,7 and Torello Lotti. (PMC)