Herbal Artichoke, the Anti Diabetes Functional Herbal Remedy in Vivo

By Kyle J. Norton


Diabetes is a medical condition caused by not enough insulin entering the bloodstream as a result of the loss of beta cells in the pancreas or insulin receptor sites clogged by plaques that are responsible for the production of insulin.

The insulin receptor sites processed a function that binds the insulin and passes the message into the cell, leading to the transformation of glucose from the blood to energy.

The hallmark of diabetes is insulin resistance. The condition has been found to increase the risk of cardiovascular disease even without the presence of diabetes.

The exact causes of insulin resistance are unknown. However, some researchers suggested that genetic preposition and lifestyle are major risk factors that cause the onset of the syndrome.

According to the statistics, in the US, between 60 to 70 million individuals are affected by insulin resistance. More than 40% of individuals older than 50 years may be at risk of insulin resistance.

Some researchers suggested that the widespread insulin resistance in the US may be a result of the promotion of the Western diet over the past few decades.

Dr. Merat S, in the examination of the Western-type diets in the risk of insulin resistance, said, "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis, but also IR, potentially complicating the interpretation of results".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researcher on the finding a natural therapeutics for the treatment of diabetes investigated the artichoke leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats.

The study included 40 male Wistar rats induced diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)) randomly assigned to orally and daily administrated of ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w).

According to the tested assays, the ethanol extract from leaves of C. scolymus showed the highest antioxidant activity and endowed the powerful inhibition in vitro of α-amylase activity with IC50=72,22 ug/uL.

In vivo, the ethanol extract from the leaves of C. scolymus (200-400 mg/kg) decreased significantly the levels of α-amylase enzymes involved in the digestion of carbohydrates in the serum of diabetic rats.

Furthermore, the administration of ethanol extract improved the anti-oxidative activity demonstrated by the increase of CAT, SOD and GSH activities in liver, kidney, and pancreas of diabetic rats.

Compared to diabetic rats, the ethanol extract from leaves of C. scolymus also decreased blood glucose rate, plasma total cholesterol (T-Ch) and triglyceride (TG) and low-density lipoproteins (LDL-C) after 28 days of treatment.

Researchers after taking into account other factors said, "These observed strongly suggest that ethanol extract from the leaves of C. scolymus has anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects".

In order to reveal additional information about artichoke antidiabetic property, researchers in the joint study lead by the Hallym University examined the Jerusalem artichoke inhibitory activity against α-glucosidase and fasting serum glucose levels.

In a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db) selected for the study, water extract of PJA fermented by L. plantarum, and two strains of Bacillus subtilis injection showed the highest α-glucosidase inhibitory activity in vitro, compared to original Jerusalem artichoke (PJA).

PJA fermentation group significantly lower blood glucose concentration than the control.

At the end 7 weeks, PJA fermentation group also induced higher levels of serum insulin and HDL cholesterol levels and lower the concentrations of triglycerides, non-esterified fatty acids, and total cholesterol.

Additionally, the intestinal α-glucosidase activity was partially inhibited.y the PJA fermentation injection.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats by Ben Salem M1, Ben Abdallah Kolsi R2, Dhouibi R1, Ksouda K1, Charfi S3, Yaich M4, Hammami S1, Sahnoun Z1, Zeghal KM1, Jamoussi K4, Affes H. (PubMed)
(2) Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice by Wang Z1, Hwang SH1, Lee SY2, Lim SS. (PubMed)

Plant-Based Betanin Kills Colon Cancer Cells by Toxicity

By Kyle J. Norton

Colon cancer is a medical and chronic condition caused by the irregular growth of cells in the colon, due to the alternation of cell DNA.

Colon formed part of the digestive tract, including the large intestine with a function to reabsorb fluid before passing them back to the blood and remove waste through the anus.

Colon cancer is one most slow cancer compared to other cancers. In some patients, colon cancer may exist in the colon more than 20 years before it is discovered.

According to the statistic provided by the American Cancer Society, in 2019, approximately, 101,420 new cases of colon cancer will be diagnosed. Colon cancer also causes the death of 51,020 deaths. during 2019.

The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Out of many risk factors involved in the onset of colorectal cancer, aging is one of the major culprits, according to the epidemiological studies.

The median age diagnosed with colon cancer is 68 in men and 72 in women compared to the age of 63 of rectal cancer in both men and women.

However, over the past few decades, the incidence of colon cancer has been found to rise in the younger age groups, probably due to the promotion of a high-fat diet.

Dr. Robb Bird, the editor at the worldwide health wrote, "Poor diet is associated with about 80 percent of colorectal cancer cases. Even 20 years ago studies were attributing colon cancers to high-fat diets. Colorectal cancer is the third most common cancer in the United States with more than 130,000 cases reported every year. These cancers are a result of a combination of several causes including genetic, epigenetic and environmental causes, such as diet. Hopefully, with more research, the exact pathways by which diet leads to cancer can be discovered. Once discovered, blocking these pathways can hopefully reduce the negative impact of a high-fat diet on colon cancer risk".

Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

Om finding a potential compound for the treatment of continuing colonic inflammation, an important risk factor in the development of colorectal cancer, researchers examined phytochemical compound betanin isolated from beetroot (Beta vulgaris var. rubra) effects against colon cancer.

In patients with inflammatory bowel disease, such as ulcerative colitis (UC) and Crohn's disease (CD), administration of betanin exerted an inhibition against the oxidative DNA damage and induced apoptosis in neutrophils from the blood, compared to those obtained in colon carcinoma-derived Caco-2 cells.

In IBD patients' neutrophils, betanin treatment at the concentration of 100 μM for 24 h modulated the immune function by exerting anti-inflammatory activity, assessed by comet assay.

In Caco-2 cells, injection of H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.

Betanin also exhibited the protein associated with pro-apoptotic function accompanied by the loss of mitochondrial transmembrane potential in the energy transformation.

On other words, betanin promotes the ROS cytotoxicity that leads to colon cancer cell death without harming to the nearby cells through its antioxidant activity.

The findings strongly suggested betanin exerts anti-inflammatory and potentially cancer preventive activity.

Taken altogether, betanin isolated from beetroot may be considered supplements for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High-fat diet found to stimulate cell growth in the colon, increasing the risk of colon cancer by the World Health Net

Healthy Food Ginger Protects the Digestive System Against Indigestion in Human Studies

By Kyle J. Norton


Dyspepsia is another term of indigestion. One of the common symptoms for people with acute and chronic gastrointestinal disorder including gastroesophageal reflux disease (GERD), stomach ulcers, or gallbladder disease.

Some common symptoms of indigestion include persistently recurrent pain or discomfort in the upper abdomen.

Some patients with indigestion may also experience symptoms of digestive tract discomforts such as bloating, belching, nausea and vomiting, acidic taste and a growling stomach.

The onset of indigestion is depending on the underlying causes. Risk factors associated with indigestion may include excessive alcohol drinking, long-term use of certain stomach irritating medicines, people with a stomach ulcer and psychological problems such as anxiety or depression in which the circulation of blood are diverted away from the digestive tract.

Some researchers suggested that people who follow the Western diet which promote high fat intake, red meats, processed foods are at substantial risk of indigestion.

Dr. Duncanson KR, the lead scientist in the evaluated the risk of food and functional dyspepsia, wrote, "Functional dyspepsia (FD) is a debilitating functional gastrointestinal disorder characterized by early satiety, post-prandial fullness or epigastric pain related to meals, which affects up to 20% of western populations". and "Dietary fat was associated with FD in all three studies that specifically measured this association".

Ginger (Zingiber officinale) or ginger root, the second superfood used thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural compound for the treatment of functional dyspepsia with no side effect,  researchers examined the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia compared to those of Western medicines.

The clinical trial included 11 patients with functional dyspepsia were studied twice in a randomized double-blind manner. After an 8-h fast, the patients ingested three capsules containing ginger (total 1.2 g) or placebo, followed after 1 h by 500 mL low-nutrient soup.

According to the tested assays, gastric emptying was more rapid after ginger compared to placebo [median (range) half-emptying time 12.3 (8.5-17.0) min after ginger, 16.1 (8.3-22.6) min after placebo, P≤0.05].

Antral contractions (P=0.06)was found more in the ginger group compared to placebo but fundus dimensions and gastrointestinal symptoms, nor did other parameters associated with dyspepsia.

Dr. the lead scientist wrote, "Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia, but had no impact on gastrointestinal symptoms or gut peptides".

In order to learn more about the effect of ginger against dyspepsia, scientists compared the efficacy of a ginger and artichoke supplementation versus placebo in the treatment of FD.

A prospective multicentre, double-blind, randomized, placebo-controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was performed.with 2 capsules/day were supplied (before lunch and dinner) to 126 FD patients (supplementation/placebo: 65/61) was conducted.

After 14 days of treatment, supplementation group (SG) showed a significant amelioration (SG: α S = +1.195 MCA score units and higher intercept (α) compared to placebo.

In other words, the ginger supplement showed a superior improvement of all parameter in patients with dyspepsia compared to placebo.

Further analysis of each parameter, researchers found that SG processes a significant advantage in nausea epigastric fullness, epigastric pain, and bloating.

Dr. the lead scientist, after taking other factors into account, wrote, "The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease".

Take all together, ginger may be considered a functional alternative for the treatment of dyspepsia, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Effect of ginger on gastric motility and symptoms of functional dyspepsia by Hu ML1, Rayner CK, Wu KL, Chuah SK, Tai WC, Chou YP, Chiu YC, Chiu KW, Hu TH. (PubMed)
(2) The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial by Giacosa A1, Guido D2, Grassi M2, Riva A3, Morazzoni P3, Bombardelli E3, Perna S4, Faliva MA4, Rondanelli M4. (PubMed)

Herbal Artichoke Protects the Blood Vessels Against the Risk of CVD

By Kyle J. Norton


Vasoprotection is a term characterized by protecting your blood vessel against the onset of heart disease and stroke.

Blood vessel formed part of the vascular or circulation system that transports the oxygen and nutrients blood to the body tissue and removes unnecessary waste products.

The circulation system also plays an essential role in transporting hormones to the body needs.

The most common cause of abnormal vascular system is the accumulation of plaque on the arterial wall due to the deposit blood cholesterol and other substances such as calcium and cadmium, leading to hardening and narrowing the arteries over time.

Atherosclerosis is a disease associated with plaque builds up inside the arteries, a major cause of heart disease and stroke.

Vascular disease can be serious. Blood clots can clog vessels and block blood flow to the heart or brain.

Some researchers suggested that widespread vascular disease in the Western world probably is associated with the promotion of the Western diet over the past few decades.

Dr. Rachel P Ogilvie, the lead scientist, in the examination of the Western diet in the risk of vascular disease, wrote, "Peripheral arterial disease (PAD) is a costly source of morbidity and mortality among older persons in the United States. Dietary intake plays a role in the development of atherosclerotic cardiovascular disease".

And, "...greater meat consumption was associated with a higher risk".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researcher on the finding a natural therapeutic with vasoprotective activity investigated investigate the effects of artichoke on iNOS expression in human coronary artery smooth muscle cells (HCASMC).

The study included HCASMC incubated with a cytokine mixture to induce nitric oxide synthases (iNOS) mRNA expression.

Application of an artichoke leaf extract (1-100 µg/mL, 6 h or 24 h) inhibited the levels of iNOS in concentration- and time-dependent manner.

By inhibiting the expression of iNOS, the artichoke leaf extract also reduced proinflammatory cytokine activation by iNOS.

Where nitric oxide synthases are a family of enzymes involved in the production of nitric oxide from L-arginine.

And, Nitric oxide (NO) induces anti-inflammatory effect under normal physiological conditions. However, under abnormal conditions, NO is considered a pro-inflammatory mediator-induced inflammation.

Additional analysis of the extract against NO in the induction of vascular inflammation and intimal hyperplasia, researchers found that the vasoprotection of the extract was attributed to the four well-known artichoke compounds including cynarin, cyanidin, luteolin, and cynaroside.

In other words, artichoke contains both endothelial nitric-oxide synthase (eNOS-exhibition and iNOS-inhibition compounds.

Where eNOS- is a critical regulator of cardiovascular homeostasis.

Furthermore, in order to reveal more information about nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature, researchers examined the effect of artichoke extract incubated with human umbilical vein endothelial cells (HUVECs),

According to the luciferase reporter gene assay, artichoke leaf extract (ALE) increased the activity of the human eNOS promoter in EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs).

By comparing the application of different doses used in the experiment, researchers found organic subfraction from ALE was more potent in this respect than the crude extract, whereas an aqueous subfraction of ALE was without effect in EA.hy 926 cells.

Futhermore, injection of ALE and the organic subfraction increased eNOS mRNA expression and eNOS protein expression both in EA.hy 926 cells and HUVECs.

Interestingly, the flavonoids luteolin and cynaroside increased eNOS promoter activity and eNOS mRNA expression, compared to no effect of caffeoylquinic acids cynarin and chlorogenic acid.

In other words, artichoke increased eNOS gene transcription for the protection of cardiovascular profile was also attributed additionally by the lipid-lowering and antioxidant properties.

Taken altogether, artichoke may be considered a functional remedy for the protection of blood vessels against the risk of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells by Xia N1, Pautz A1, Wollscheid U1, Reifenberg G1, Förstermann U1, Li H. (PubMed)
(2) Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells by Li H1, Xia N, Brausch I, Yao Y, Förstermann U. (PubMed)
(3) Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study by Rachel P Ogilvie, Pamela L Lutsey, Gerardo Heiss Aaron R Folsom, and  Lyn M Steffen (Oxford)

Herbal Ginger, the Best Anti- Neuroinflammation Functional Food

By Kyle J. Norton

Scientists may have found a kitchen spice for the treatment of neuroinflammation in the initiation of a gradual loss of neurons, according to studies.

Inflammation is a natural response of the immune system against the invasion of foreign pathogens.

In the acute phase of infection, immune system after receiving the message from the CNS stimulates the production of blood platelet to cover up the wound and proinflammatory cytokines to the site of infection with an aim to kill off all stimuli or pathogens before entering to the body.

Some anti-inflammatory cytokines normally produced to counteract the inflammation in the body under normal condition also switch off to produced proinflammatory cytokines instead.

Most microorganisms try to enter the body through damaged tissue or wound are destroyed in this phase of infection. However, overproduction of proinflammatory has seen to damage or death of the nearby healthy cells and tissue, leading to the abnormal formation of scars.

Our immune system has evolved over thousands and thousands of year by killing off all new and transformed microorganisms or adapting to the new change if foreigners cannot be eradicated within 3 to 8 weeks, causing low-grade inflammation in the facilitation of the onset of various chronic illness.

In other words, chronic inflammation or chronic low-grade inflammation is the diseases associated with the inability of the immune system to destroy all foreign invaders in the acute phase of infection.

Neuroinflammation is a condition caused by inflammation of the nervous tissue due to infection, traumatic brain injury, toxic metabolites, or autoimmunity.

Similar to the immune response to the aforementioned macrophage, neuroinflammation is associated with the microglia, the innate immune cells of the central nervous system (CNS) that mediates these neuroinflammatory responses.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of neuroinflammation with no side effects investigated 6-shogaol, a bioactive compound found in ginger anti-inflammatory effects against oligomeric forms of the Aβ (AβO) in animal brains.

Administration of 6-shogaol significantly reduced microgliosis, an intense reaction of CNS microglia to pathogenic insults and astrogliosis, an abnormal increase in the number of astrocytes due to the destruction of nearby neurons in intrahippocampal AβO-injected mice.

 6-gingerol also ameliorated AβO and scopolamine-induced memory impairment and elevated production of pro-inflammatory cytokines and pre- and post-synaptic marker, an indication of cognitive decline in the hippocampus.

Based on these results, researchers said, "All these results suggest that 6-shogaol may play a role in inhibiting glial cell activation and reducing memory impairment in animal models of dementia".

Additionally, in order to reveal more information about ginger anti neuroinflammation, researchers examined the bioactive compounds of ginger by using lipopolysaccharide (LPS)-activated BV2 microglia culture model.

Except for zingerone and all gingerols and shogaols compounds at a concentration of 20 μM inhibited the production of pro-inflammatory cytokines in the brain, including nitric oxide, IL-1β, IL-6, and TNF-α by blocking the protein associated with the activation.

Furthermore, the ginger bioactive compound also inhibited the mRNA levels in LPS-activated BV2 microglia. 

Moreover, the fresh ginger extract exhibited a significant anti-neuroinflammatory capacity due to the presence of 10-gingerol.

Take all together, ginger processed a high amount of bioactive compounds may be considered a functional alternative for the prevention and treatment of neuroinflammation, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
-
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia by Moon M1, Kim HG2, Choi JG3, Oh H4, Lee PK5, Ha SK6, Kim SY7, Park Y7, Huh Y8, Oh MS. (PubMed)
(2) Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol by Ho SC1, Chang KS, Lin CC. (PubMed)

3,3'-Diindolylmethane, the Anti Colitis Bioactive and Natural Ingredient, According to Studies

By Kyle J. Norton

Colitis is a class of conditions characterized by inflammation of the inner lining of the colon, including Crohn's disease, ulcerative colitis, ischemic colitis.

Most cases of colitis are caused by infection, chronic inflammation.

Most common colitis can be classified into

* Ulcerative colitis is a chronic disease that causes inflammation and ulcers within the inner lining of your large intestine. Most cases of ulcerative colitis start in the rectum and spread to the colon.

* Pseudomembranous colitis (PC) is a type of inflammation caused by the overgrowth of the bacterium Clostridium difficile. Most cases of PC are associated with the use of antibiotics that causes the imbalance of the ratio of bacterias in the digestive tract.

* Ischemic colitis (IC) is a type of inflammation of the large intestine or colon caused by interruption of blood flow in the colon. Most cases of IC occur in older adults over 60 years of age.

Most of the common symptoms of colitis are total depending on the causes of the disease including abdominal pain, cramping, diarrhea, and blood in the stool.

If you experience some of the above symptoms, please make sure to check with your doctor to rule out the possibility.

Although there are a number of risk factors associated with the onset of colitis, an unhealthy diet may be one of the major cause in the Western worlds coincidently with the promotion of such diet overpass few decades.

According to the University of Chicago Medical Center in the study of "Western diet changes gut bacteria and triggers colitis in those at risk" in vitro, wrote in the final report, "Certain saturated fats that are common in the modern Western diet can initiate a chain of events leading to complex immune disorders in those with a genetic predisposition".

And, "This is the first plausible mechanism showing step-by-step how Western-style diets contribute to the rapid and ongoing increase in the incidence of inflammatory bowel disease."

The results provide an explanation of the Western diet risk of inflammatory bowel disease, one many forms of colitis.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers in the concerns of the chronic inflammation in ulcerative colitis (UC) associated with the risk of colon cancer (CAC) examined the effects DIM in inhibiting the microRNAs (miRNAs) expression against CAC pathogenesis.

Where MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression including inflammation and angiogenesis.

The study included the use of 3,3'-diindolylmethane (DIM) to activate aryl hydrocarbon receptor (Ahr) in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CAC in mice.

Where aryl hydrocarbon receptor is a transcription factor associated with the regulation of gene expression. 

Application DIM inhibited miR-132 expression and alleviated CAC severity by suppression of macrophage infiltration and pro-inflammatory cytokines.

 DIM improved anti-inflammatory activity by suppressing the expression of the inflammatory cytokines, including the production of TNF-α, IL-1β, and IL-6. 

Futhermore, before the injection of DIM, azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CAC mice abrogated the cholinergic anti-inflammation and exacerbated CAC through silencing miR-132 in vivo.

In other words, the injection of TCDD on AChE also is found to exhibit miR-132 in vitro in CD4+ cells and macrophages, leading to the production of inflammatory cytokines.

Dr. Alzahrani AM and colleagues wrote in the final report, "miR-132 mediates the ameliorating effects of TCDD on CAC, suggesting miR-132 as a promising therapeutic candidate to control autoimmune inflammation and tumorigenesis in CAC patients".

Taken altogether, DIM may be considered a supplement to inhibit the progression colitis (UC) in the induction of the onset of colon cancer, pending to the confirmation of larger sample size and multicenter human study.

Intake DIM in a form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Enhancing miR-132 expression by aryl hydrocarbon receptor attenuates tumorigenesis associated with chronic colitis by Alzahrani AM1, Hanieh H2, Ibrahim HM2, Mohafez O3, Shehata T4, Bani Ismail M2, Alfwuaires M. (PubMed)
(2) Western diet changes gut bacteria and triggers colitis in those at risk. (Science Daily)

Herbal Bilberry Inhibits Oral Candida Biofilms Naturally and Effectively

By Kyle J. Norton


Candida is a class of yeasts that cause fungal infections worldwide.

Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract. 

Under normal circumstances, Candida albicans do not cause harmful effects, but overgrowth results in candidiasis.

Oral candidiasis is an oral condition infected by the fungal C. albicans found mostly in people with a weakened immune system including patients who are taking the immune suppressive medicine.

Biofilms are microbial communities in which cells stick to each other and often also to a surface.

Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.

 If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.

There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.

Some researchers suggested aging may be one of the major risk factors that cause Candida overgrowth 

Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".

And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

On finding a potential herbal medicine against oral Candida biofilms., researchers examined the efficacy of cranberry fruit (Vaccinium macrocarpon Aiton) and two other red fruits (Vaccinium myrtillus L. and Malpighia punicifolia L.) on Candida albicans and Candida glabrata yeasts.

According to the low concentration added to the culture medium, the combined extract displayed significant anti-adhesion activity against Candida spp.

Furthermore, the pretreatment of surfaces with the extract also exerted a strong anti-adhesion activity mainly against C. glabrata yeasts and antibiofilm activity against C. albicans.

These results suggested that the extract inhibitory activity was dependent on concentration, species, and strain.

Moreover, observed the activity of three subfractions enriched in pro-anthocyanidins, researchers found that the components showed an anti-adhesion activity at low concentrations.

In other words, crude extracts of cranberry and Vaccinium myrtillus L. and Malpighia punicifolia L.) and their fractions process potential in the prevention of biofilms of C. glabrata.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanidins may be considered a functioning remedy against oral Candida biofilms, pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Promising results of cranberry in the prevention of oral Candida biofilms by Girardot M1, Guerineau A, Boudesocque L, Costa D, Bazinet L, Enguehard-Gueiffier C, Imbert C. (PubMed)