Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 15 March 2019

Herbal Artichoke Improves Liver Functioning

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a herbal remedy for improvement of liver functioning, according to studies.

The liver function plays a critical role in filtering blood come from the intestinal before passing them to other organs and tissues. The reddish-brown organ also detoxes toxic chemicals and metabolizes medicine and secrete bile to the intestine for breaking down food and absorbing nutrients.

Additionally, the liver is found to process the ability to secrete proteins such as albumin, fibrinogens, and apolipoproteins into the blood for the regulation of the oncotic pressure, blood clotting, and lipoprotein metabolism, respectively.

There are many factors can disrupt the liver function including viral infection, alcohol use or obesity, leading to scar formation in the liver tissue.

Long-term untreated chronic liver infection that causes the replacement of normal liver tissue by scar tissues eventually lead to cirrhosis, a non-reversible, dangerous condition that can lead to liver failure and cancer.

At the early stage of liver disease, most patients are asymptomatic. However, as the disease progression patients may experience unspecific symptoms of loss of appetite, fatigue, general malaise, gastrointestinal discomforts or weight loss.

At the advanced stage severe on the right side of the abdomen, jaundice, pale stool, harden urine color, spiderlike blood vessels on the skin, redness in the palms of the hands.

Liver damage at this stage may cause loss of period in some women and loss of sex drive, breast enlargement or testicular atrophy in men.

In the severe case, patients also have symptoms of confusion, drowsiness and slurred speech.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

On finding a natural compound for enhancing the liver function, researchers at the Laboratoire de pharmacology examined the liver protective effects of artichoke (Cynara scolymus) leaf extract.

Injection of artichoke extract improved the liver function in the production of bile and liver lipid production and lipid recycling by lowering blood cholesterol.

In animal models, the liquid extracts of the roots and leaves of artichoke also found to demonstrate an ability to protect the liver, with possibly in enhancing liver cells regenerate.

Furthermore, administration of artichoke extract reduced the risk of cardiovascular disease by lowering risk factors associated with liver function in regulating cholesterol and triglycerides.

According to the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH), artichoke improved the function of the liver by improving liver enzymes which were significantly reduced in NASH.

Taken altogether, artichoke may have a strong implication in improving the liver function in many aspects, pending to the validation of larger sample size and multicenter studies.

Thursday, 14 March 2019

Bilberry Cuts Off the Energy Supply to Cancers, Studies Found

By Kyle J. Norton

Bilberry may process a unique function in blocking the formation of the new blood vessels to fuel the tumor growth, according to studies.

Angiogenesis is the development of new blood vessels from the existing vasculature. The process has occurred throughout life in human in forms of health and disease.

Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients,

In a tumor, the availability of nutrients is limited, therefore, for the tumor to survive and to grow continuously, the tumor cells induce the formation a new blood supply from the preexisting vasculature by stimulating the protein associated with the pro-angiogenesis and facilitation of angiogenesis, such as vascular endothelial growth factor.

In other words, if we can cut off the blood vessels that provide nutrients to the tumor, we may cure cancers.

Dr. Adair TH, the lead scientists in the investigation of the angiogenesis in diseases and cancer said, "Stimulation of angiogenesis can be therapeutic in ischemic heart disease, peripheral arterial disease, and wound healing. Decreasing or inhibiting angiogenesis can be therapeutic in cancer, ophthalmic conditions, rheumatoid arthritis, and other diseases".

And, "Capillaries grow and regress in healthy tissues according to functional dem bands. Exercise stimulates angiogenesis in skeletal muscle and heart. A lack of exercise leads to capillary regression. Capillaries grow in adipose tissue during weight gain and regress during weight loss.

The results strongly suggested that by allowing or blocking the growth of new blood vessels, angiogenesis may be used as a primary target for the treatment of chronic diseases and cancers

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound which blocks the progression of cancer examined the anti-angiogenic activity of berry anthocyanins.

Six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry) included in the study were analyzed the anti-angiogenic (the ability to reduce unwanted growth of blood vessels, which can lead to varicose veins and tumor formation) properties.

Formula OptiBerry IH141, including all berries used in the study, demonstrated superior anti-angiogenic properties compared to the other combinations tested.

OptiBerry significantly inhibited free radical and proinflammatory cytokines in the expression of VEGF (Vascular Endothelial Growth Factor) associated with the formation of the new blood vessels.

According to the Matrigel assay using human microvascular endothelial cells, OptiBerry reduced the new blood vessel formation by impairing angiogenesis.

Futhermore, endothelioma cells pretreated with OptiBerry showed a diminished ability to form hemangioma and markedly decreased tumor growth by more than 50% through its anti-angiogenic, and anti-carcinogenic properties.

In order to reveal more information about berries anti-angiogenic activity to prevent and treat cancer, researchers investigated the six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seed, and strawberry) and a grape seed proanthocyanidin extract (GSPE) against the formation of new blood vessels for cancer proliferation.

Wild bilberry and blueberry extracts possessed the highest antioxidant activity observed by the ORAC values compared to other berries.

In other words, wild bilberry and blueberry extracts inhibited the overexpression of free radicals and proinflammatory cytokines in stimulating the production of VEGF (Vascular Endothelial Growth Factor) in enhancing angiogenesis.

Interestingly, these activities of wild bilberry and blueberry extracts were not shared by other antioxidants such as alpha-tocopherol or GSPE but were commonly shared by pure flavonoids.

Taken altogether, bilberry used alone or combined with other berries may be considered functional remedies for the prevention of angiogenesis and treatment of cancer cells proliferation by stimulating the formation of a new blood vessel, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula by Bagchi D1, Sen CK, Bagchi M, Atalay M. (PubMed)
(2) Anti-angiogenic property of edible berries by Roy S1, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. (PubMed)
(3) Chapter 1Overview of Angiogenesis by Adair TH, Montani JP.. (NCBI)

Artichoke, the Potential Anti Thyroid Cancer Herbal Remedy with No Side Effects, Scientists Reveal

By Kyle J. Norton

Scientists may have found a herbal remedy for the treatment of thyroid cancer with no side effect, according to studies.

Thyroid cancer is a chronic and medical condition characterized by irregular cell growth in the thyroid gland due to the alternation of cell DNA.

Most cases of thyroid cancer start in the cells on the surface of the inner lining of the gland, affecting the thyroid function in hormone production in the early stage.

About 45% of thyroid cancer is found in the population over the age of 45. According to the statistic, approximately over 53,000 adults in the United States are diagnosed with thyroid cancer every year.

In other words, the risk of thyroid cancer is about 4% a year, according to the data from 2005 to 2014. Overall, the 5-year survival rate for people with thyroid cancer is 98%.

The exact causes of thyroid cancer are unknown. Epidemiological studies suggested that people who have a family history of goiter, exposure to high levels of radiation, and certain hereditary syndromes are at an increased risk of the incidence.

Some researchers suggested that if you are female, your risk of thyroid cancer is increased substantially compared to the male counterpart.

Dr. Reza Rahbari, the lead scientist in the study to examine the thyroid cancer gender disparity, said, "Thyroid cancer is one of the fastest growing cancer diagnoses worldwide. It is 2.9-times more common in women than men".

And, "Recent studies on estrogen receptor status in thyroid cancer show a difference in the receptor subtypes expressed based on the histology of thyroid cancer. Moreover, the response to estrogen is dependent on the specific estrogen receptor expressed in thyroid cancer cells".

The results clearly suggested that the risk of thyroid cancer is 2.9 higher in the female, probably due to the response to the hormone estrogen.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural chemo compound for the treatment of thyroid cancer examined the antithyroid cancer activity of the sesquiterpene lactone cynaropicrin, a major constituent of the artichoke leaves extracts.

The aim of the study was to investigate the effects of cynaropicrin, a major compound from the sesquiterpenes on the grown of three human thyroid carcinoma cell lines.

Injection of cynaropicrin showed to inhibit the viability of CAL-62, 8505C and SW1736 cells in a dose- and time-dependent way, with an EC50 of about 5 mM observed after 48 h of treatment.

In the cellular growth assays, cynaropicrin inhibited the cell proliferation through the arrest of the cell cycle, mainly in the G2/M phase, observed by the presence of a significant percentage of necrotic cells.

Furthermore, the differentiation after 48 h of treatment with 10 mM of cynaropicrin suggested that the compound induced cell apoptosis also through the inhibition of the proteins associated with cellular survival and cell cycle division.

Moreover, the application also reduced the free radical activity in exhibiting the expression of lipid peroxidation, without any significant effect on the reactive oxygen species production.

These results clearly suggested that cynaropicrin exhibited the function of free radical in exerting the cytotoxic effect against the thyroid cancer without causing harm to the healthy nearby cells through its antioxidant activity.

Taken altogether, artichoke processed abundantly bioactive compound sesquiterpene lactone cynaropicrin may be considered a functional remedy for the prevention and treatment of thyroid cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1)Antiproliferative effects of cynaropicrin on anaplastic thyroid cancer cells by Lepore SM1, Maggisano V1, Lombardo GE1, Maiuolo J1, Mollace V1, Bulotta S1, Russo D1, Celano M. (PubMed)
(2) Thyroid cancer gender disparity by Reza Rahbari,1 Lisa Zhang,1 and Electron Kebebew. (PMC)

3,3'-Diindolylmethane, the Phytochemical Which Gobbles Up Liver Cancer Cells

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of liver cancer with no side effects, according to studies.

The liver is the largest internal organs in the human body which plays a critical role for maintaining the integrity of cells wall, production of vitamin D and steroid hormone and aiding the digestive system in absorption of nutrients, through the production of cholesterol.

Additionally, the liver also filters out waste from the blood coming from the digestive system before passing them to the other parts of the body.

Liver cancer is a medical condition caused by irregular cell growth in the tissues of the liver.

Most cases of liver cancer start in the cells on the surface of the inner lining of the liver tissues before penetrating into deeper layers of the liver.

At the early stage due to the small size of the tumor and lack of nerve tissues, most patients are asymptomatic.

However, at the advanced stage, cancer cells can travel a distance away from the liver to infect other healthy tissues and organs, leading to secondary metastasis.

Patients at this stage may experience the general symptoms of cancers such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue accompanied by the symptoms of persistent upper abdominal pain, abdominal swelling, jaundice, and chalky stools.

If you have some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility of liver cancer.

Out of many risk factors associated with the onset of liver cancer, some researchers suggested that people who carry hepatitis viral may have a substantially higher risk of the disease.

Dr. Marc Ringehan, the lead researcher said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause of HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year".

And, "The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease".

Scientists in seeking potential and bioactive compounds for the treatment of liver cancer examined 3'3-Diindolylmethane (DIM, the major product of the acid-catalyzed oligomerization of indole-3-carbinol anti-liver cancer properties.

In two HCC cell lines SMMC-7721 and MHCC-97H, injection of DIM inhibited the proliferation, migration, and invasion of cancer cells.

In nude mice, DIM significantly decreased the volumes of SMMC-7721 orthotopic liver tumor and suppressed lung metastasis.

Furthermore, DIM decreased the level of phospho-FAK (Tyr397) which is found elevated in both vitro and in vivo.

The DIM anti-cancer cells efficacy on proliferation, migration, and invasion are probably due to the inhibition of the expression of matrixes (MMP2-9) associated with the promotion of cancer cells growth and invasion.

Dr. Li WX, the lead scientist wrote, "These results demonstrated that DIM blocks HCC cell metastasis by suppressing tumor cell migration and invasion".

Moreover, in order to reveal more information about DIM anti-liver cancer activity, researchers investigated whether diindolylmethane effect on HA59T cells.

At concentrations of 10-75 μM, diindolylmethane killed cells in a concentration-dependent manner, particularly, in diindolylmethane (25-50 μM) induced apoptosis in a concentration-dependent manner.

The cytotoxic effect of diindolylmethane against the tested liver cancer cell line was not reversed by chelating cytosolic Ca(2+).

Where Calcium (Ca2+) ions are important for cellular signaling. Its flow plays an essential role in regulating several secondary messenger systems in neural adaptation for visual, auditory, and the olfactory system.

The results suggested that DIM inhibited the onset and progression of liver cancer through a number of mechanisms, including proteins involved in anti-cell proliferation and migration, and promotion of apoptosis.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling by Li WX1, Chen LP2, Sun MY1, Li JT1, Liu HZ1, Zhu W. (PubMed)
(2) Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells by Cheng JS1, Shu SS, Kuo CC, Chou CT, Tsai WL, Fang YC, Kuo LN, Yeh JH, Chen WC, Chien JM, Lu T, Pan CC, Cheng HH, Chai KL, Jan CR. (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)

Phytochemical Sinigrin Protects the Neuron Against Toxicity

By Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound for the treatment of neuro-toxicity, according to studies.

Neuroprotection is anything used or intake for the protection of neurons in the brain.

Neurotoxicity is a condition in which the structure or function of the central and/or peripheral nervous system have been damaged due to the presence of biological, chemical or physical toxins.

Neurons are the cells in the brain with a unique function in which the information is being received processed, and transmitted from cell to cell, muscle, or gland cells.

Neuron toxicity can occur to any parts of the brain, depending on the types of neurotoxin. Symptoms of neurotoxicity are also depending on the neurons specific functions, the neurotransmitters affected.

According to the Integrative Psychiatry, symptoms may include

* Brain fog – loss of mental focus, ADD, ADHD, impaired memory, poor decision making;

* Insomnia – difficulty falling asleep, staying asleep, or both

* Pain – migraines, fibromyalgia.

* Obesity – metabolic syndrome, insulin resistance, and diabetes.

These results clearly suggested that neurotransmitters imbalance can cause a wide range of diseases.

Researchers on finding a natural compound which processes neuroprotective effects examined the Allyl isothiocyanate (AITC), presented in Wasabia japonica (wasabi), and an aliphatic isothiocyanate derived from the precursor sinigrin on neurotoxicity.

Pretreatment with AITC significantly inhibited the production of free radical NO induced by nitric oxide synthase (iNOS) and protein (COX-2) associated with inflammation.

Injection of AITC decreased the expression of proinflammatory cytokines such tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2) during the acute phase of infection.

Furthermore, AITC inhibited the nuclear factor NF-κB induced the oxidative stress and the pathway involved in directing cellular responses.

Moreover, AITC also protected the microglia damage induced by overexpression of pro-inflammatory cytokine TNF-α.

The results strongly suggested that AITC exerts anti-neuroinflammatory effects on microglial cells, which may have clinical significance in neurodegeneration.

Taken altogether, sinigrin a bioactive ingredient may be considered a functional supplement for the prevention and treatment of neuro-toxicity, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

Wednesday, 13 March 2019

Bilberry May Process Depressant-Like Effects

By Kyle J. Norton

Depression is a mood disorder, affecting the patients feel, think, and handle daily activities

Acute depression comes and goes is a normal response formed a part of our daily lives such as a loss of a job, the death of a loved one, and illness.

Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.

However, chronic depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

Researchers don't know what causes exactly depression. Neither they know why some people are more prone to depression while many do not.

However, according to epidemiological studies, a major illness, culture shock, family history, social and family isolation due to other mental illnesses or other factors, physical, sexual, or emotional abuse, long-term use of medication, such as isotretinoin and genetic preposition can contribute to the risk of developing clinical depression.

Given to the cultural diversity in Canada, there is no doubt that many immigrants come to the country try to adapt to the change of culturally and socially, some of them may be culturally shocked that can lead to major depression.

Dr. Natali Creglia, in the article "Impact of Cultural Shock on Mental Health" wrote, "According to Analysis of Impact of Culture Shock on Individual Society by Junzi Xia, “When these people lose all familiar signs and symbols of social intercourse, they have to try to adapt themselves to different lifestyles, living conditions and business practices in a new cultural setting. However, this is a long term and difficult process. In this condition, feelings of alienation accumulate sharply because of poor adaptation. Consequentially, culture shock occurs, followed by a series of psychological confusion and emotional discomfort. (Hess, 1994)” (Xia, 2009). Individuals experiencing cultural shock have to adjust to a completely new way of life".

And "Customs and beliefs of their homeland do not apply in this new area anymore. This is often where the idea of being ‘weird’ or ‘awkward’ originates from. Psychological stress begins to emerge. This stress is the starting point to much deeper psychological problems. “Although not everyone will experience all the symptoms, almost all people will experience some parts. The major symptoms may be described as depression, anxiety and feelings of helplessness (Mio, 1999)” (Xia, 2009) Sense of isolation occurs in most individuals as does a sense that the personal culture has been lost.

These results strongly suggested that immigrants come to Canada who can not adapt to the new cultures may experience psychological confusion and emotional discomfort from time to time, leading to culture shock induced-depression.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the differentiation of natural compound for the treatment of depression, researchers evaluated the antidepressant-like effects of water VBF extract (VBFW) in an animal model.

In a mouse model of chronic restraint stress (CRS), VBFW treatment significantly reduced the immobility time and increased swimming time in forced swim test (FST) without altering the locomotor activity in unstressed mice.

CRS mice treated with VBFW showed a reduction of depression by exhibiting significantly decreased immobility time in FST and serum corticosterone (CORT), increased locomotor activity in the open field test (OFT), and enhanced brain monoamine neurotransmitters.

Futhermore, VBFW ameliorated depression-related behavior and promoted neurogenesis by exhibiting functions of the extracellular signal-regulated kinase (ERK) signaling pathway in the hippocampus and prefrontal cortex (PFC).

Moreover, VBFW also acted as an agonist in neuromodulation against the 5-HT receptor that binds the (5-hydroxytryptamine, 5-HT) in the induction of depression.

Dr. Oh DR the lead scientist said, " Our study provides evidence that antidepressant-like effects of VBFW might be mediated by the regulation of monoaminergic systems and glucocorticoids".

Also, in a mouse model of chronic restraint stress (CRS), CRS-exposed mice treated with VBLW (100 and 200 mg/kg) showed a similar effect of the above study by significantly reduced immobility time and increased swimming and climbing times in the FST, and increased locomotor activity in the OFT.

CRS mice treated with VBLW exhibited the antidepressant-like activity by significantly decreased levels of serum corticosterone (CORT) and adrenocorticotropin hormone (ACTH), but enhanced brain monoamine neurotransmitters.

Increased levels of CORT and ACTH and protein levels of monoamine oxidase A (MAOA) and SERT and decrease tryptophan hydroxylase-2 (TPH2) protein levels, were found in patients with depression.

CRS mice treated with VBLW had dramatically decreased protein levels of MAO-A and serotonin transporter (SERT) but increased TPH2 protein levels in the hippocampus and the PFC.

Taken altogether, bilberry processed antidepressant-like activity may be considered a herbal remedy for the treatment of depression, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antidepressant-Like Effects of Vaccinium bracteatum in Chronic Restraint Stress Mice: Functional Actions and Mechanism Explorations by Oh DR1,2, Kim Y1, Choi EJ1, Jung MA1, Oh KN1, Hong JA1, Bae D1, Kim K1, Kang H1, Kim J1, Kim YR2, Cho SS3, Choi CY. (PubMed)
(2) Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation by Oh DR1,2, Yoo JS3, Kim Y1, Kang H1, Lee H1, Lm SJ1, Choi EJ1, Jung MA1, Bae D1, Oh KN1, Hong JA1, Jo A1, Shin J1, Kim J1, Kim YR2, Cho SS4, Lee BJ3, Choi CY. (PubMed)
(3) Impact of Cultural Shock on Mental Health By Natali Creglia. (Hastac)

Honey, the Best Natural Remedy for Chronic Otitis Externa With No Side Effects

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a herbal medicine for the prevention and treatment of acute otitis externa, according to studies.

Acute otitis externa is a condition characterized by the inflammation of the ear canal. Most cases of acute cute otitis externa are associated with the infection by Pseudomonas aeruginosa and Staphylococcus aureus due to the improper cleaning.

However, people with seborrhoeic dermatitis caused by inflammation of greasy areas of the skin can also lead to infection of the ears.

Most common symptoms of acute otitis include itching, canal edema, canal erythema, and otorrhea.

Most cases of acute otitis externa are healed within days with proper ear drops. However, there is a rare case that the disease may take weeks or months to recover.

Chronic otitis externa shares the common symptoms of the acute form, accompanied by water retention and severe ear pain and temporary loss of hearing, due to building up thick and dry skin can build up inside the ear canal, leading to narrowing the ear canal.

Untreated of chronic otitis externa can cause deafness.

Besides sharing the risk factors with the acute form, otitis externa can also be caused by infection due to long-term use of hearing aids and earplugs.

Unlike the acute form, most cases of otitis externa are treated with steroid drops in addition to antibiotics accompanied by oral intake of pain medications such as ibuprofen.

Generally, oral antibiotics are not recommended, however, if the infection has spread beyond the ear canal, oral antibiotics may be applied.

According to the statistics, otitis externa affects 1–3% of people in America a year and 95% of people complaints of the condition are acute.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On the finding a natural ingredient for the treatment of eczematous external otitis, scientists investigated the antibacterial potential of medical honey eardrops as treatment of eczematous external otitis.

15 patients diagnosed with recurrent eczematous external otitis were selected and treated with medical honey eardrops for 2 weeks.

Honey treatment resulted in less discomfort and itching and decreased signs of eczema with no side effects, according to assays.

Although honey eardrops showed a strong in vitro inhibitory activity against all tested strains, it did not eradicate Staphylococcus aureus infection.

Honey eardrops also reduced the visual analog scale of ear complaints, a score of eczema, and increased the eradication of bacterial infection. Most patients in the study, are satisfied with the use of honey eardrops for the treatment of their eczematous external otitis.

Dr. Henatsch D, the lead scientist, after taking into account co and confounders said, "The results of this preliminary study indicate a possible role of honey eardrops in eczematous ear disease".

Taken altogether, honey may be considered a functional remedy for the treatment of eczematous external otitis, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof-of-Concept Study by Henatsch D1, Nabuurs CH1, van de Goor RM1, Wolffs PF2, Stokroos RJ. (PubMed)
(2) Alternative Treatments for Atopic Dermatitis: An Update by Shi K1, Lio PA. (PubMed)
(2) Acute Otitis Externa: An Update by PAUL SCHAEFER, MD, PhD, and REGINALD F. BAUGH, MD. (AAFP)