Bilberry May Process Depressant-Like Effects

By Kyle J. Norton

Depression is a mood disorder, affecting the patients feel, think, and handle daily activities

Acute depression comes and goes is a normal response formed a part of our daily lives such as a loss of a job, the death of a loved one, and illness.

Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. 

However, chronic depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself. 

Researchers don't know what causes exactly depression. Neither they know why some people are more prone to depression while many do not.

However, according to epidemiological studies, a major illness, culture shock, family history, social and family isolation due to other mental illnesses or other factors, physical, sexual, or emotional abuse, long-term use of medication, such as isotretinoin and genetic preposition can contribute to the risk of developing clinical depression. 

Given to the cultural diversity in Canada, there is no doubt that many immigrants come to the country try to adapt to the change of culturally and socially, some of them may be culturally shocked that can lead to major depression.

Dr. Natali Creglia, in the article "Impact of Cultural Shock on Mental Health" wrote, "According to Analysis of Impact of Culture Shock on Individual Society by Junzi Xia, “When these people lose all familiar signs and symbols of social intercourse, they have to try to adapt themselves to different lifestyles, living conditions and business practices in a new cultural setting. However, this is a long term and difficult process. In this condition, feelings of alienation accumulate sharply because of poor adaptation. Consequentially, culture shock occurs, followed by a series of psychological confusion and emotional discomfort. (Hess, 1994)” (Xia, 2009). Individuals experiencing cultural shock have to adjust to a completely new way of life".

And  "Customs and beliefs of their homeland do not apply in this new area anymore. This is often where the idea of being ‘weird’ or ‘awkward’ originates from. Psychological stress begins to emerge. This stress is the starting point to much deeper psychological problems. “Although not everyone will experience all the symptoms, almost all people will experience some parts. The major symptoms may be described as depression, anxiety and feelings of helplessness (Mio, 1999)” (Xia, 2009) Sense of isolation occurs in most individuals as does a sense that the personal culture has been lost.

These results strongly suggested that immigrants come to Canada who can not adapt to the new cultures may experience psychological confusion and emotional discomfort from time to time, leading to culture shock induced-depression.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the differentiation of natural compound for the treatment of depression, researchers evaluated the antidepressant-like effects of water VBF extract (VBFW) in an animal model.

In a mouse model of chronic restraint stress (CRS), VBFW treatment significantly reduced the immobility time and increased swimming time in forced swim test (FST) without altering the locomotor activity in unstressed mice.

CRS mice treated with VBFW showed a reduction of depression by exhibiting significantly decreased immobility time in FST and serum corticosterone (CORT), increased locomotor activity in the open field test (OFT), and enhanced brain monoamine neurotransmitters.

Futhermore, VBFW ameliorated depression-related behavior and promoted neurogenesis by exhibiting functions of the extracellular signal-regulated kinase (ERK) signaling pathway in the hippocampus and prefrontal cortex (PFC).

Moreover, VBFW also acted as an agonist in neuromodulation against the 5-HT receptor that binds the (5-hydroxytryptamine, 5-HT) in the induction of depression.

Dr. Oh DR the lead scientist said, " Our study provides evidence that antidepressant-like effects of VBFW might be mediated by the regulation of monoaminergic systems and glucocorticoids".

Also, in a mouse model of chronic restraint stress (CRS), CRS-exposed mice treated with VBLW (100 and 200 mg/kg) showed a similar effect of the above study by significantly reduced immobility time and increased swimming and climbing times in the FST, and increased locomotor activity in the OFT.

CRS mice treated with VBLW exhibited the antidepressant-like activity by significantly decreased levels of serum corticosterone (CORT) and adrenocorticotropin hormone (ACTH), but enhanced brain monoamine neurotransmitters.

Increased levels of CORT and ACTH and protein levels of monoamine oxidase A (MAOA) and SERT and decrease tryptophan hydroxylase-2 (TPH2) protein levels, were found in patients with depression.

CRS mice treated with VBLW had dramatically decreased protein levels of MAO-A and serotonin transporter (SERT) but increased TPH2 protein levels in the hippocampus and the PFC.

Taken altogether, bilberry processed antidepressant-like activity may be considered a herbal remedy for the treatment of depression, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antidepressant-Like Effects of Vaccinium bracteatum in Chronic Restraint Stress Mice: Functional Actions and Mechanism Explorations by Oh DR1,2, Kim Y1, Choi EJ1, Jung MA1, Oh KN1, Hong JA1, Bae D1, Kim K1, Kang H1, Kim J1, Kim YR2, Cho SS3, Choi CY. (PubMed)
(2) Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation by Oh DR1,2, Yoo JS3, Kim Y1, Kang H1, Lee H1, Lm SJ1, Choi EJ1, Jung MA1, Bae D1, Oh KN1, Hong JA1, Jo A1, Shin J1, Kim J1, Kim YR2, Cho SS4, Lee BJ3, Choi CY. (PubMed)
(3) Impact of Cultural Shock on Mental Health By Natali Creglia. (Hastac)

Honey, the Best Natural Remedy for Chronic Otitis Externa With No Side Effects

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a herbal medicine for the prevention and treatment of acute otitis externa, according to studies.

Acute otitis externa is a condition characterized by the inflammation of the ear canal. Most cases of acute cute otitis externa are associated with the infection by Pseudomonas aeruginosa and Staphylococcus aureus due to the improper cleaning.

However, people with seborrhoeic dermatitis caused by inflammation of greasy areas of the skin can also lead to infection of the ears.

Most common symptoms of acute otitis include itching, canal edema, canal erythema, and otorrhea.

Most cases of acute otitis externa are healed within days with proper ear drops. However, there is a rare case that the disease may take weeks or months to recover.

Chronic otitis externa shares the common symptoms of the acute form, accompanied by water retention and severe ear pain and temporary loss of hearing, due to building up thick and dry skin can build up inside the ear canal, leading to narrowing the ear canal.

Untreated of chronic otitis externa can cause deafness.

Besides sharing the risk factors with the acute form, otitis externa can also be caused by infection due to long-term use of hearing aids and earplugs. 

Unlike the acute form, most cases of otitis externa are treated with steroid drops in addition to antibiotics accompanied by oral intake of pain medications such as ibuprofen.

Generally, oral antibiotics are not recommended, however, if the infection has spread beyond the ear canal, oral antibiotics may be applied.

According to the statistics, otitis externa affects 1–3% of people in America a year and 95% of people complaints of the condition are acute.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On the finding a natural ingredient for the treatment of eczematous external otitis, scientists investigated the antibacterial potential of medical honey eardrops as treatment of eczematous external otitis.

15 patients diagnosed with recurrent eczematous external otitis were selected and treated with medical honey eardrops for 2 weeks. 

Honey treatment resulted in less discomfort and itching and decreased signs of eczema with no side effects, according to assays.

Although honey eardrops showed a strong in vitro inhibitory activity against all tested strains, it did not eradicate Staphylococcus aureus infection.

Honey eardrops also reduced the visual analog scale of ear complaints, a score of eczema, and increased the eradication of bacterial infection. Most patients in the study, are satisfied with the use of honey eardrops for the treatment of their eczematous external otitis.

Dr. Henatsch D, the lead scientist, after taking into account co and confounders said, "The results of this preliminary study indicate a possible role of honey eardrops in eczematous ear disease".

Taken altogether, honey may be considered a functional remedy for the treatment of eczematous external otitis, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof-of-Concept Study by Henatsch D1, Nabuurs CH1, van de Goor RM1, Wolffs PF2, Stokroos RJ. (PubMed)
(2) Alternative Treatments for Atopic Dermatitis: An Update by Shi K1, Lio PA. (PubMed)
(2) Acute Otitis Externa: An Update by PAUL SCHAEFER, MD, PhD, and REGINALD F. BAUGH, MD. (AAFP)

Phytochemical Sinigrin, Kills Cancer Cells, Before They Can Spread, According to Studies

By Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound for killing cancer cells before they can spread, according to studies.

Cancer is a group of diseases characterized by cell growth irregularly in the tissue of the body, including glands and organs due to the alternation of cell DNA.

In normal cells, through the process of mitosis, the new cells are born through the division of one cell into two with an aim to replace cells that have been lost, damaged, or worn out. The cell division cycle is closely regulated and they can give rise to only a limited array of cells.

The characteristics of cancer cell growth are completely different compared to normal cells. The cancer cell can divide indefinitely; They are out of control by the immune system. They don't follow the signals of stop division,.... and they do not have a specific function.

How cancer grows? Most cancers stimulate the production of a new blood vessel for nutrition and the function of producing enzymes that break down normal cells and tissues.

All cancers share the general symptoms of unintended weight loss, loss of appetite, fatigue, and tiredness and gastrointestinal discomforts accompanied by the specific symptoms depending on the location of cancer or the organ that was affected.

Out of a number of risk factors, some researchers suggested the creation of obesity in the modern world may be one of the major risk factor associated with the incidence.

Dr. Nathan A. Berger in the evaluation of obesity and risk of cancer wrote, "Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and worse prognosis for many but not all malignancies".

And, " lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effect of dietary fats and cholesterol as cancer promoters, and the mechanisms by which the intestinal microbiome affects obesity and cancer".

The results showed a relationship between unhealthy diet risk of obesity in the induction of cancer.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on finding a natural compound for the treatment of cancers examined sinigrin, the bioactive ingredient in cruciferous vegetables for their health benefits and cancer prevention properties in vitro against HL60 (human promyelocytic leukemia cell line) systems.

According to the HL60 assays, sinigrin showed the tumoricidal activity of plant samples (IC50 = 0.28 mg·mL(-1)) by breaking down the products of sinigrin hydrolysis.

Sinigrin also exerted a significant effect in the induction of tumor genotoxicity and proliferation with causing harm to the nearby healthy cells.

The finding strongly suggested that the efficacy of cruciferous vegetables in inducing cancer cell death and proliferation was attributed to the presence of bioactive ingredient sinigrin.

Furthermore, in a model of carcinogen-induced hepatotoxicity in rats, injection of sinigrin significantly inhibited the proliferation of liver tumor cells without inducing liver toxicity.

Injection of the compound for a period of 3 months exhibited pro-apoptotic activity against liver cancer by activating the tumor suppressive gene in the rats.

The active bioactive compound also inhibited the cancer cell proliferation through deactivating the production of proteins associated with liver cancer cells differentiation.

The effect of sinigrin against liver cancer is also found to cancer cell cycle arrest in the in G0/G1 phase.

The results clearly suggest that sinigrin processes important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats.

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of cancer, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin by Lozano-Baena MD1, Tasset I2, Obregón-Cano S3, de Haro-Bailon A4, Muñoz-Serrano A5, Alonso-Moraga Á. (PubMed)
(2) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(3) Obesity and cancer pathogenesis by Nathan A. Berger. (PMC)

3,3'-Diindolylmethane, May Be Potent Against Glioblastoma, Scientists Say

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of glioblastoma (GBM) and resistant glioblastoma with no side effects, according to studies.

Glioblastoma is one of the most aggressive cancers that begins within the brain.

According to statistics,  most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients is survived longer than five years.

If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.

The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.

Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that causes the incidence.

Dr. Judith Schwartzbaum, an associate professor of epidemiology and a member of The Ohio State University’s Comprehensive Cancer Center, in the study focused on the relationship between chemical signals from the immune system and the development of brain cancer uncovered the relationship between allergies, the immune system, and brain cancer. It appears that allergies may protect against the development of brain cancer.

She wrote, "It's important to identify the early stages of tumor development if we hope to intervene more effectively. " and "If you understand those early steps, maybe you can design treatments to block further tumor growth".

The results strongly suggested that people with a weakened immune system such as the elderly may be at a higher risk of glioblastoma

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers in the concern of current therapy deficits for treatment glioblastoma due to the limitation of limits the transport of essential drugs to the tumor sites. examined the effects of 3,3'-diindolylmethane by encapsulation in poly (lactic-co-glycolic acid) nanoparticles.

Nanoformulation loading of 27-87nm and encapsulation efficiency of 7.2% and 70% respectively showed to induce the glioma cells apoptosis internally.

Furthermore, in vivo, a bio-distribution study revealed the selective accumulation of the nanoformulation into rat brain tumor sites by crossing the blood-brain barrier.

Moreover, the nanoformulation also exhibited the abrogation of epidermal growth factor receptor pathway which has been found to that promote the growth and spread of glioblastoma cells.

Dr. Bhowmik A, the lead scientist after taking into account co and confounders, wrote, "Our novel nano preparation, therefore, shows great promise to serve as a template for targeted delivery of other therapeutics in treating GBM".

In order to reveal more information about the prognosis for glioblastoma patients, researchers examined the 3,3'-diindolylmethane anti glioblastoma activity.

Indole-3-carbinol and related fragments, including 3,3'-Diindolylmethane exerted a potent anti glioblastoma activity with low micromolar activity, particularly resistant glioblastoma cell culture.

The finding clearly suggested that 3,3'-diindolylmethane alone or encapsulated in poly (lactic-co-glycolic acid) nanoparticles induced the glioblastoma cells and resistant glioblastoma cells death through a number of mechanisms.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells by Sherer C1, Tolaymat I2, Rowther F3, Warr T3, Snape TJ. (PubMed)
(2) Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3'-diindolylmethane nanoparticles through blood brain barrier prevents glioma progression by Bhowmik A1, Chakravarti S1, Ghosh A2, Shaw R1, Bhandary S2, Bhattacharyya S3, Sen PC2, Ghosh MK. (PubMed)
(3) Immune System Research May Help Brain Tumor Diagnosis by Health Line

Phytochemical Alliin Protects the Heart Muscles Against Cardiotoxicity

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the prevention and treatment of cardiotoxicity with no side effects, according to studies.

Cardiotoxicity is a medical condition induced by the damage of the heart muscle. The infected heart muscles may reduce the function of the heart in pumping blood, the condition which can lead to heart failure.

Most cases of cardiotoxicity are the results of long-term intake of certain medication such as chemotherapy. However, infected by human immunodeficiency virus (HIV) genetic preposition, a malignant disease associated with the amyloid deposited on your heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some prevalent factors found in patients with cardiotoxicity.

Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating,

Physically, most patients with cardiotoxicity also experience symptoms of enlarged heart muscle examined by the chest X-ray, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.

Conventionally, treatment of cardiotoxicity depending on the cause of the disease may include

* Beta-blockers, for the improvement of the blood flow and reduction of palpitations, arrhythmias, and high blood pressure.

*ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow.

* Diuretics, by getting rid of excess fluids that reduce heart function in blood pumping

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a natural ingredient for the prevention and treatment of cardiotoxicity, researchers evaluated the preventive role of S-allyl cysteine sulphoxide (SACS, alliin) in isoproterenol (ISO)-induced cardiotoxicity in an animal model.

The study included male Wistar rats induced myocardial infarction by subcutaneous injection of isoproterenol (ISO) (150 mg/kg) once a day for 2 days, following by the pretreatment of SACS (40 and 80 mg/kg) orally daily for a period of 35 days using an intragastric tube.

Pretreatment of SACS showed a significantly lowered thiobarbituric acid reactive substances (TBARS) and increased the levels of antioxidant enzymes produced by the host.

The reduced levels of the concentration of reduced glutathione (GSH) in myocardial infarcted rats also increased with the injection of SACS.

SACS pretreatment also increased significantly the levels of mitochondrial phospholipids and decreased the levels of mitochondrial cholesterol, free fatty acids (FFAs), triglycerides (TGs) and calcium, and the activity of xanthine oxidase (XOD) in heart, elevated conditions have been found to induce heart disease. 

Where low levels of mitochondrial phospholipids have been found to involve heart failure.

Futhermore, SACS also increased the enzyme activity of oxidative phosphorylation in the mitochondrial fraction of the heart.

Moreover, oral administration of SACS for a period of 35 days protected the heart function in the myocardial infarction without affecting the heart function in the normal control rats.

The findings strongly suggested the protective role of SACS against cardiotoxicity caused by subcutaneous injection of medication.

Dr. Sangeetha T, the leads scientist wrote in the final report, "The effect at a dose of SACS 80 mg/kg was more effective than the dose 40 mg/kg. The results of the study conclude that SACS protect the mitochondria of the ISO-induced myocardial-infarcted rats".

Taken altogether, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cardiotoxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol-induced cardiotoxicity in male Wistar rats: a histopathological study by Sangeetha T1, Darlin Quine S. (PubMed)

Ginger, the Magic Pungent Spice for the Treatment of Muscle Pain

By Kyle J. Norton

Scientists may have found a natural ingredient for the treatment of muscle pain with no side effects, according to study.

Muscle pain is the condition of pain originated from the muscle. Muscle pain may be caused by injury or overexertion, infections of soft tissues, or inflammatory conditions.

Systemic muscle pain is the pain throughout the body, often induced by an infection, an illness or a side effect of long-term intake of certain medication, such as cholesterol medications.

There are many risk factors associated with muscle pain, including
1. Physical activity (PA) that requires the intensity, duration, and repetitiveness of muscular activity.

2. Occupations often involved static load, repetitive movements, and high peak forces, occurring for the prolonged duration are also some risk factors that causally relate to muscle pain development.

3. Overtraining in physical exercise.

Most muscle pains can be treated with over counter painkillers. If you are currently taking them for the treatment of muscle pain, please make sure you know all the side effects for preventive measure.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of muscle pain quickly examined the effects of 11 days of raw (study 1) and heat-treated (study 2) ginger supplementation on muscle pain.

Study 1 and 2 were identical double-blind, placebo-controlled, randomized experiments with 34 and 40 volunteers, respectively

Also, participants consumed 2 grams of either raw (study 1) or heated (study 2) ginger or placebo for 11 consecutive days and participants performed 18 eccentric actions of the elbow flexors to induce pain and inflammation.

According to the assays, ginger showed a significant pain reduction in 24 hours after eccentric exercise compared to placebo.

There was no significant difference between both types of ginger and placebo on other measures.

Daily supplementation with ginger reduced muscle pain caused by eccentric exercise, and this effect was not enhanced by heat treating the ginger.

Dr. and colleagues wrote, "daily consumption of raw and heat-treated ginger resulted in moderate-to-large reductions in muscle pain following exercise-induced muscle injury".

In order to reveal additional information about ginger in treating muscle pain, researchers evaluated the acute effects of ginger on muscle pain, inflammation, and dysfunction induced by eccentric exercise.

The double-blind, cross-over design, included 27 participants performed 24 eccentric actions of the non-dominant elbow flexors and ingested a 2 g dose of ginger or placebo 24 h and 48 h after exercise.

Before ginger treatment, eccentric exercise caused moderate arm pain (39 ± 20 mm; mean ± SD) and dysfunction (14% decrease in ROM) and an increase in volume (1.8%).

Ginger consumption demonstrated no effect on muscle pain, dysfunction, or metabolic rate compared with placebo before 24 hours.

However, after 24 hours, arm pain was reduced (13%, -5.9 ± 8.8 mm) the following day, 48 h after exercise.

Based on the finding, researchers said, "a single 2 g dose of ginger does not attenuate eccentric exercise-induced muscle pain, inflammation or dysfunction 45 min after ingestion. However, ginger may attenuate the day-to-day progression of muscle pain".

Take all together, ginger may be considered a functional alternative for the treatment of muscle pain after 24 hours, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise by Black CD1, Herring MP, Hurley DJ, O'Connor PJ. (PubMed)
(2) Acute effects of dietary ginger on muscle pain induced by eccentric exercise by Black CD1, O'Connor PJ. (PubMed)
(3) Physical Activity as Cause and Cure of Muscular Pain: Evidence of Underlying Mechanisms by Karen Søgaard and Gisela Sjøgaard. (PMC)

Artichoke, the Mediator for Sex Steroid Hormone Metabolism, According to Studies

By Kyle J. Norton

Artichoke may have a profound and positive effect on sex steroid hormone metabolism with no side effects, according to studies.

The steroid hormones are hormones made mainly by endocrine glands such as the gonads (testis and ovary), the adrenals and (during gestation) by the fetoplacental unit.

In other words, steroid hormones can be grouped into two classes: corticosteroids (typically made in the adrenal cortex, hence cortico-) and sex steroids (made in the gonads or placenta).

Metabolism plays many important roles in steroid hormone action in reaching the target of production and stopping production when the target is reached within the target tissues.

The function of sex steroid hormone is to influence the maintenance and growth of muscles, and the decline in androgens, estrogens, and progesterone due to aging are associated with the loss of muscular function and mass.

In male puberty, testosterone, the sex hormones produced by luteinizing hormone (LH) and follicle-stimulating hormone (FSH), plays an important role in the physical changes associated with puberty, and in testicular maturation.

In female puberty, increased hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) stimulates the production of hormones including estrogen and progesterone, leading to breast change and menstrual period.

In the reproductive function, sex steroid hormones stimulate the development of the maturing ovarian follicle and control ovum production in the female and sperm production in the male.

In the nonreproductive function, receptors for estrogens, progesterone, and androgens are associated with the function of bone, brain, cardiovascular system. The results suggested that sex steroid hormones may play a critical role in the pathophysiology of some diseases (osteoporosis, Alzheimer, atherosclerosis).

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding potential and natural ingredient for the mediation of the sex steroid hormones and metabolic activity examined the effects of a combination botanical supplement on premenopausal women.

The placebo-controlled, parallel-arm, pilot study tested the effects of two naturopathic interventions over five menstrual cycles in 40 healthy premenopausal women.

Participants were given either dietary changes (3 servings/d crucifers or dark leafy greens, 30 g/d fiber, 1-2 liters/d water, and limiting caffeine and alcohol consumption to 1 serving each/wk; n = 10), and placebo (n = 15).

During the early follicular phase, the botanical supplement decreased dehydroepiandrosterone (DHEA), an endogenous steroid hormone(-13.2%; P = 0.02), which has been found to affect how estrogen works. Increased expression of DHEA is associated with the sensitive conditions of breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids and dehydroepiandrosterone-sulfate (-14.6%; P = 0.07).

Compared to placebo, the formula also inhibited the levels of dehydroepiandrosterone-sulfate (DHEA-S), an endogenous androstane steroid that is produced by the adrenal cortex and a possible markers for hypothalamic-pituitary-adrenal (HPA) function in patients with large pituitary adenomas.

Furthermore, the combination reduced the expression of androstenedione, a steroid hormone in a normal range and improved the production of the hormone testosterone and enhanced recovery and growth from exercise, and increased sexual desire and performance. Overexpression of androstenedione has been found to facilitate the growth of endometrial cancer.

Levels of estrone-sulfate a form of estrogen found to alleviate symptoms of menopause as hormone replacement therapy also decreased by the injection of the formula. Increased levels of estrone-sulfate are involved in the onset of Cancers associated with the response to estrogen.

Also compared to placebo, no other trends or statistically significant changes were observed. In other words, comparing dietary changes with placebo, no statistically significant differences were observed other than those mentioned above.

The findings strongly suggested that the formula may have strong activity against the overexpression of certain steroid hormones involved the risk of mammary cancers.

Taken altogether, artichoke used alone or combined with other herbal medicine including Curcuma longa, Rosmarinus officinalis, Schisandra chinensis, Silybum marinum, and Taraxacum officinalis may be considered mediation of steroid hormones against the onset of certain cancers in premenopausal women, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women by Greenlee H1, Atkinson C, Stanczyk FZ, Lampe JW. (PubMed)