Artichoke, the Mediator for Sex Steroid Hormone Metabolism, According to Studies

By Kyle J. Norton

Artichoke may have a profound and positive effect on sex steroid hormone metabolism with no side effects, according to studies.

The steroid hormones are hormones made mainly by endocrine glands such as the gonads (testis and ovary), the adrenals and (during gestation) by the fetoplacental unit.

In other words, steroid hormones can be grouped into two classes: corticosteroids (typically made in the adrenal cortex, hence cortico-) and sex steroids (made in the gonads or placenta).

Metabolism plays many important roles in steroid hormone action in reaching the target of production and stopping production when the target is reached within the target tissues.

The function of sex steroid hormone is to influence the maintenance and growth of muscles, and the decline in androgens, estrogens, and progesterone due to aging are associated with the loss of muscular function and mass.

In male puberty, testosterone, the sex hormones produced by luteinizing hormone (LH) and follicle-stimulating hormone (FSH), plays an important role in the physical changes associated with puberty, and in testicular maturation.

In female puberty, increased hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) stimulates the production of hormones including estrogen and progesterone, leading to breast change and menstrual period.

In the reproductive function, sex steroid hormones stimulate the development of the maturing ovarian follicle and control ovum production in the female and sperm production in the male.

In the nonreproductive function, receptors for estrogens, progesterone, and androgens are associated with the function of bone, brain, cardiovascular system. The results suggested that sex steroid hormones may play a critical role in the pathophysiology of some diseases (osteoporosis, Alzheimer, atherosclerosis).

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding potential and natural ingredient for the mediation of the sex steroid hormones and metabolic activity examined the effects of a combination botanical supplement on premenopausal women.

The placebo-controlled, parallel-arm, pilot study tested the effects of two naturopathic interventions over five menstrual cycles in 40 healthy premenopausal women.

Participants were given either dietary changes (3 servings/d crucifers or dark leafy greens, 30 g/d fiber, 1-2 liters/d water, and limiting caffeine and alcohol consumption to 1 serving each/wk; n = 10), and placebo (n = 15).

During the early follicular phase, the botanical supplement decreased dehydroepiandrosterone (DHEA), an endogenous steroid hormone(-13.2%; P = 0.02), which has been found to affect how estrogen works. Increased expression of DHEA is associated with the sensitive conditions of breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids and dehydroepiandrosterone-sulfate (-14.6%; P = 0.07).

Compared to placebo, the formula also inhibited the levels of dehydroepiandrosterone-sulfate (DHEA-S), an endogenous androstane steroid that is produced by the adrenal cortex and a possible markers for hypothalamic-pituitary-adrenal (HPA) function in patients with large pituitary adenomas.

Furthermore, the combination reduced the expression of androstenedione, a steroid hormone in a normal range and improved the production of the hormone testosterone and enhanced recovery and growth from exercise, and increased sexual desire and performance. Overexpression of androstenedione has been found to facilitate the growth of endometrial cancer.

Levels of estrone-sulfate a form of estrogen found to alleviate symptoms of menopause as hormone replacement therapy also decreased by the injection of the formula. Increased levels of estrone-sulfate are involved in the onset of Cancers associated with the response to estrogen.

Also compared to placebo, no other trends or statistically significant changes were observed. In other words, comparing dietary changes with placebo, no statistically significant differences were observed other than those mentioned above.

The findings strongly suggested that the formula may have strong activity against the overexpression of certain steroid hormones involved the risk of mammary cancers.

Taken altogether, artichoke used alone or combined with other herbal medicine including Curcuma longa, Rosmarinus officinalis, Schisandra chinensis, Silybum marinum, and Taraxacum officinalis may be considered mediation of steroid hormones against the onset of certain cancers in premenopausal women, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women by Greenlee H1, Atkinson C, Stanczyk FZ, Lampe JW. (PubMed)

Bilberry Promotes Normal Gut Microbiome for Optimizing Overall Health

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a whole fruit for the improvement of the ratio of the gut microbiome, according to studies.

Gut microbiota is the microbe population (tens of trillions) that lives in the intestine.

Gut microbiota plays a critical role in human overall health by assisting nutrient metabolism, xenobiotic and drug metabolism and maintaining the structural integrity of the gut mucosal barrier, immunomodulation, and protecting the gut against pathogens.

However, according to the joint study led by the Asian Institute of Gastroenterology, Asian Healthcare Foundation, these functions in adults may be disrupted by several factors, including the use of antibiotics or antibiotic and diet.

Furthermore, gut microbiota also constitutes a natural defensive barrier to gut infection in a stable condition. Alternation of the gut microbiota due to infection, diet and/or lifestyle has been found to induce diseases, such as inflammatory bowel diseases and cancer.

People with colon cancer were found to associate with gut microbial imbalance (dysbiosis). In other words, many changes in the bacterial composition of the gut microbiota may contribute to the development of colorectal cancer.

Out of the many risk factors involved the alternation of the gut microbiome, some researchers suggested that xenobiotics and toxicological effects may have a  strong impact on human health.

Dr. the lead scientist in the assessment of gut microbiome change on chemical risk said, " it is highly likely that the toxic effects of ingested xenobiotics are significantly enhanced or reduced by the gut microbiota".

And, "Xenobiotic suppression or enhancement of proliferation of specific groups of intestinal microbes may lead to alterations of the composition of the intestinal bacterial population, which in turn is known to affect the permeability of the intestinal epithelium...  It is thus highly likely that the integrity of the gut barrier can be affected by the changes induced by microbiota-disrupting chemicals. This may, in turn, lead to alteration in the uptake of the given chemical, as well as of other toxic and/or beneficial components present in the gut".

The results strongly suggested that injection of xenobiotic can cause a significant change in the ratio gut microbiota homeostasis, a leading cause of a number of chronic diseases.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural remedy which processed a strong effect in the improvement of digestive system examined the bilberry effect on intestinal barrier function and digestive enzyme activity, through regulating the gut microbiota in aging rats.

Aging rats selected to the study were orally injected by a medium-dose bilberry anthocyanin extract (20 mg per kg bw per day) which is considered the optimum amount to regulate the intestinal function.

Injection of the experimental medium-dose bilberry anthocyanin extract showed a significant improvement of the gut/microbiome by allowing the good bacterias to growth and restricting the growth of harmful bacterias in the digestive tract.

Compared to the experimental dose, high-dose bilberry anthocyanin extract consumption altered some intestinally beneficial bacteria in an adverse way.

Furthermore, according to the tested analysis, the promotion of the gut microbiome was correlated with the changes in short-chain fatty acids and the intestinal mucosal barrier in the absorption of nutrients.

Moreover,  the medium-dose bilberry anthocyanin extract also decreased the activity of digestive enzymes in the tested rats.

In other words, the tested dose improved the digestive function through promoting healthy gut/microbiome and nutrients absorption with the needs of low levels of digestive enzymes which have been found in lower levels in the aging population.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a function remedy for the improvement of levels of gut/microbiome for optimal health, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The Seventh Biennial Berry Health Benefits Symposium by Seeram NP 1, Burton-Freeman B. (PubMed)
(2) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X1. (PubMed)
(3) Role of the normal gut microbiota by Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, and D Nageshwar Reddy. (PMC)
(4) Impact of the gut microbiota on chemical risk assessment by Time  Rask Licht and Martin Iain Bahl. (Science Direct)

Honey the Best Natural Treatment of High Blood Pressure with No Side Effects, Scientists Say

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy for normalizing the blood pressure, according to studies.

Hypertension is a chronic condition caused by abnormally high blood pressure.

High blood pressure is a condition of a cluster of metabolic syndrome associated with the increased risk of heart disease and stroke.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

In high blood pressure individuals, due to the elevated blood pressure in your arteries, the heart has to work harder than normal to pump blood through the blood vessels.

In low blood pressure individuals, the reduced blood pressure in the arteries drops can cause the heart to pump blood at a slower rate than normal.

According to the standard guidelines, the levels of blood pressure is normal if it is more than 120 over 80 and less than 140 over 90 (120/80-140/90).

People with blood pressure lower than 120/80 are considered normal without accompanied by symptoms of light-head or dizziness.

According to the statistics provided by the CDC, in the U.S. 29% or 100 millions of the adults have hypertension during 2015–2016 and hypertension prevalence increased with age and was 33.2% among those aged 40–59 and 63.1% among those aged 60 and over.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

Researchers in the course of finding a natural ingredient for the treatment of high blood pressure investigated the safety and effect intrapulmonary administration (by inhalation) of 60 % honey solution, 10% dextrose or distill water in normal or diabetic subjects.

Twenty-four healthy subjects, 16 patients with type 1 diabetes mellitus and six patients with hypertension were selected to participate in the study.

Twelve healthy subjects were subjected for distilling water inhalation for 10 min, and after one week they received inhalation of honey solution (60% wt/v) for 10 min. Another 12 healthy subjects received inhalation of 10% dextrose for 10 min.

Honey treatment showed a mild reduction of blood pressure compared to no change in another group.

In time perspective, systolic and diastolic blood pressure was reduced by honey inhalation in hypertensive patients at 60 and 120 min.

After taking into account co and confounders, researchers said, "honey inhalation was safe and effective in reducing...elevated blood pressure in hypertensive patients".

Moreover, in order to obtain more information of honey antihypertensive activity, researchers investigated the aqueous extract obtained from the mixture of the fresh leaf of Persea Americana, stems and a fresh leaf of Cymbopogon citratus, fruits of Citrus medica and honey on ethanol and sucrose-induced hypertension in rats.

Rats included in the study were divided into eight groups of 6 rats each and daily treated for 5 weeks. The control group received distilled water (1 mL/kg) while rats of groups 2, 3 and 4 received ethanol 40 degrees (3 g/kg/day), 10% sucrose as drinking water and the two substances respectively.

The remaining groups received additional sucrose and ethanol, the aqueous extract (50, 100 and 150 mg/kg) or nifedipine (10 mg/kg) respectively.

Group treated with ethanol and sucrose showed a significantly (p < 0.001) increased the blood pressure and the heart rate compared to distilled water treated-rats.

Chronic treatment of ethanol and sucrose also exerted a significantly decreased the activities of antioxidant enzymes produced by the host, observed by the levels of superoxide dismutase (SOD) and catalase (CAT) and elevated levels of oxidative stress observed by the stress marker malondialdehyde (MDA) levels.

However, administration of the aqueous extract or nifedipine prevented all changes caused by chronic ethanol and sucrose, including the hemodynamic, biochemical, oxidative and histological impairments.

The finding clearly suggested that aqueous extract including honey possess antihypertensive activity by the improvement of biochemical and oxidative status, through its antioxidant property.

Taken altogether, honey used alone or combined with other herbs may be considered anti hypertension functional remedies with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intrapulmonary administration of natural honey solution, hyperosmolar dextrose or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: their effects on blood glucose level, plasma insulin and C-peptide, blood pressure and peaked expiratory flow rate by Al-Waili N1. (PubMed)
(2) Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P. (PubMed)

Phytochemical Betanin, Protects the Liver Against Toxicity in Vivo, Scientists Found

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of liver toxicity with no side effects, according to studies.

Acute liver toxicity is a condition characterized by the harmful effects of a substance or organism induced by a single or short-term exposure.

Liver toxicity, on the hand, is caused by long term exposure to a substance or substances, including alcohol inducing the destruction and interruption of liver tissues regeneration, leading to fibrosis and cirrhosis.

The liver is the largest internal organs with the self-regenerative property. It only plays an essential role in the production of bile to aid digestive functioning, but also filters out blood from the digestive system before passing them back to the heart and other parts of the body.

Most common chronic liver diseases in the Western world are non-alcoholic fatty liver disease (NAFLD) and hepatitis C infection.

According to statistics, NAFLD affects 75 to 100 million Americans in 2017.  Approximately 80% of obese and 20% of normal-weight people have NAFLD.

Believe it or not, nearly 2.4 million Americans or 1 percent of the adult population were living with hepatitis C.

A most common cause of acute liver toxicity is Acetaminophen overdose in the United States, leading to acute liver failure.

Dr. Flores YN, the lead scientist in the examination of risk factors for liver disease among Mexican adults in the US and Mexico wrote, "excessive alcohol consumption is a risk factor for liver disease, but only 60% correctly identified hepatitis C, being overweight or obese, or having diabetes as risk factors".

And, " Identifying the specific risk factors, levels of knowledge and prevention activities that affect specific racial/ethnic populations is important in order to effectively target efforts to prevent liver disease".

Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural compound for the protection of liver against toxicity researchers examined the betanin (a natural pigment) mitigated effect in Organophosphates (OP)-induced hepatotoxicity in primary rat hepatocytes.

Administration of betanin (25μM) significantly increased liver cell viability, inhibited the expression of ROS formation and LPO, restored cellular antioxidant levels.

When it was used alone, betanin protected the liver against OPs-induced hepatotoxicity through inhibition of oxidative stress and mitochondrial protection against inflammation.

In order to reveal more information about betanin (from natural pigments) anti-oxidant properties against paraquat-induced liver injury in an animal model.

The study included rats randomly divided into four groups: a control group, a paraquat group, and two groups that received betanin at doses of 25 and 100mg/kg/day three days before and two days after they were administered paraquat.

Paraquat-induced liver toxicity in Sprague-Dawley rats without treatment of betanin showed significant liver toxicity observed by elevated serum aspartate aminotransferase and alanine aminotransferase levels and an increase of enzyme associated with phase I drug metabolism reactions.

In other words, the injection of paraquat led to an unbalanced ratio of free radicals and deleted antioxidant enzymes produced by the host evidenced by levels of oxidative stress.

Injection of betanin not only inhibited the historical change and the aforementioned conditions, but the phytochemical also protected the liver cells against mitochondrial damage and apoptosis-inducing factor protein levels.

Dr. Han J, the lead scientist based on the finding wrote in the final report, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".

Taken altogether, betanin may be considered supplements for the treatment of acute liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(2) Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway by Han J1, Zhang Z2, Yang S2, Wang J2, Yang X2, Tan D. (PubMed)
(3) Risk factors for liver disease and associated knowledge and practices among Mexican adults in the US and Mexico by Flores YN1, Lang CM, Salmerón J, Bastani R. (PubMed)

Ginger, The Best Gastroprotective Functional Pungent Spice

Kyle J. Norton

Ginger may have a significant effect on the prevention and treatment of the gastrointestinal disorder, some scientists suggested.

Gastrointestinal disorders are medical conditions, involving esophagus, stomach, small intestine, large intestine, and rectum.

Most common gastrointestinal disorders are very mild associated with digestive discomforts that can be resolved in a few days.

The gastroprotective effect is an action that protects the gastrointestinal tract against the onset of any disease, including infection and inflammation.

The causes of digestive disorders can be multiple. Most gastrointestinal disorders caused directly by the disorders of the digestive system such as poor diet pattern. However, long-term use of certain medication can also induce gastrointestinal disorders, including Manticholinergic medication, non-steroidal anti-inflammatory drugs, and antibiotics.

In the searching a diet therapy that can reverse and protect the digestive system against gastrointestinal disorder, researchers at the University of Florida, wrote, "Diet therapy through the elimination of offending foods such as wheat gluten or lactose, or inclusion of specialized products such as medium chain triglycerides or elemental formulas, can sustain nutritional status".

And "Dietary components such as insoluble fiber appear to have physiologic effects, while soluble fibers may have metabolic effects important to diabetes and cardiovascular disease".

Additionally, in the differentiation of types of diet may have a direct contribution to reduce the risk of gastrointestinal disorders, the authors continued, "Avoiding offending foods by Crohn's patients is an acceptable practice as long as entire categories of foods are not deleted. Avoiding all foods containing gluten from wheat, rye, barley, and oats, however, is a crucial prerequisite to recovery from celiac disease. Gluten is commonly used as a stabilizer, emulsifier, and extender in the food industry and is not always shown on food labels. Careful consultation with a registered dietitian can identify hidden sources of gluten in the diet.".

These results clearly indicated, depending on types of gastrointestinal disorder, diet therapy with modification could have a strong impact on the prevention of the onset of the disease.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural whole food which processes gastrointestinal protective effects, researchers looked into rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, an important kitchen spice, possessing myriad health benefits.

In laboratory animals., ginger was shown to be effective in preventing gastric ulcers induced by nonsteroidal anti-inflammatory drugs [NSAIDs like indomethacin, aspirin], reserpine, ethanol, and acetic acid and Helicobacter pylori-induced gastric ulcerations.

The gastroprotective efficacy of ginger was attributed to its free radical scavenging, antioxidant; inhibition of lipid peroxidation activities.

Furthermore, in the evaluation of the gastroprotective effect to examine the turmeric (Curcuma longa) and ginger (Zingiber officianale), researchers conducted a study in the ethanol-induced ulcers animal model.

Selected rats were given 100, 500 and 1000 mg/kg body weight orally.

Application of TEO and GEO inhibited ulcer caused by injection of ethanol by 84.7% and 85.1%, respectively, as seen from the ulcer index.

The reduced antioxidant enzymes such as GPx, SOD, catalase and GSH produced by alcohol administration were significantly (p<0.001) increased by simultaneous administration of TEO and GEO.

Ethanol-induced lesions such as necrosis, erosion, and hemorrhage of the stomach wall were significantly reduced after oral administration of essential oils.

These results strongly suggested, turmeric and ginger exerted a significant gastroprotective effect against gastrointestinal lesions with no side effects.

Taken altogether, ginger may be considered a functional for the prevention and combined with primary medicine for the treatment of gastrointestinal disorders,

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe) by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Gastroprotective activity of essential oils from turmeric and ginger by Liju VB, Jeena K, Kuttan R. (PubMed)
(3) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats by Ko JK1, Leung CC. (PubMed)
(4) Dietary therapy in gastrointestinal disease by Anderson CR1, Cerda JJ. (PubMed)

Celery, the Potent Anti Hypertension Functional Food with No Side Effects

By Kyle J. Norton

Celery, the tasty vegetable may be used for the prevention and treatment of hypertension, some scientists suggested.

Hypertension is the most common syndrome in the Western world caused by abnormally high blood pressure.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.

The veggie can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

There is no single cause of hypertension. Epidemiological studies suggested an unhealthy lifestyle such as a diet with high saturated and trans fat, red meat and processed food and low fruits and vegetables, smoking, overweight and obesity contributes to the onset of hypertension.

In the differentiate the correlation between the Western diet which had been promoted by the industries over the last many decades and the risk of hypertension, researchers indicated, the Western diet is one of major culprit associated to the rise of high blood pressure incidence in the adults of the Western world.

In other words, if you follow the Western diet, you will have chronic high blood pressure developed in some points during your lifetime. Luckily, if you make a change to a healthy diet, your risk of high blood pressure is reduced.

Dr. Hojhabrimanesh A, the lead scientists in the metabolic team at the Shiraz University of Medical Sciences in the classification of dietary risk of hypertension wrote, " three major dietary patterns were identified, among which only the Western pattern (abundant in soft drinks, sweets and desserts, salt, mayonnaise, tea and coffee, salty snacks, high-fat dairy products, French fries, and red or processed meats) had a significant association with BP".

And " After adjusting for potential confounders in the analysis of covariance models, multivariable adjusted means of the systolic and mean BP of subjects in the highest tertile of the Western pattern score were significantly higher than those in the lowest tertile".

With an aim to find a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Mashhad University of Medical Sciences assessed the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP).

In animal study, elected rats were induced hypertension by the injection of deoxycorticosterone acetate.

The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally to examine the tested animal antihypertensive effects on BP and heart rate (HR), compared to the spironolactone as a diuretic and positive control.

Application of all extracts decreased BP and increased the HR in hypertensive rats, with no effect on normotensive rats.

In volume analysis, administration of 300 mg/kg of hexanic, methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the celery seed caused 38, 24, and 23 mmHg reduction in BP and 60, 25, and 27 beats per minute increase in the HR, respectively.

The effects of celery seed extracted were found to process high amounts of n-butylphthalide (NBP), which has been proven epidemiologically an antihypertensive constituent.

According to the HPLC analysis data revealed that the hexanic extract demonstrated the greatest effect in normalizing the high blood pressure due to the containing the 3.7 and 4 times NBP greater than that of the methanolic and aqueous-ethanolic extracts.

Dr. Moghadam MH, the lead scientist wrote in the final report, " celery seed extracts have antihypertensive properties, which appears to be attributable to the actions of its active hydrophobic constitutes such as NBP" and, "can be considered an antihypertensive agent in the chronic treatment of elevated BP".

Additionally, in the study to evaluate the inverse associations of overall vegetable intake to blood pressure (BP); whether such relations prevail for both raw and cooked vegetables, researchers launched a review of the report of the cross-sectional associations of vegetable intakes with BP for 2195 Americans ages 40-59 in the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP).

According to the multiple linear regression assay, intakes of both total raw and total cooked vegetables considered separately were inversely related to BP in multivariate-adjusted models.

There is no difference among commonly consumed individual raw and cooked vegetable in reducing high blood pressure, particularly in cooked celery.


Taken altogether, celery, cooked or raw processed high amounts of n-butylphthalide (NBP) is considered a functional food for the prevention and treatment of high blood pressure with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) Relations of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study by Chan Q1, Stamler J, Brown IJ, Daviglus ML, Van Horn L, Dyer AR, Oude Griep LM, Miura K, Ueshima H, Zhao L, Nicholson JK, Holmes E, Elliott P(PubMed)
(3) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
(4) A Western dietary pattern is associated with higher blood pressure in Iranian adolescents by Hojhabrimanesh A1, Akhlaghi M1,2, Rahmani E2, Amanat S2, Atefi M2, Najafi M2, Hashemzadeh M2, Salehi S2, Faghih S. (PubMed)

Herbal Cascara Sagrada (Rhamnus purshiana), the Potent Anti-Prostate Cancer Functional Herb, Researcher Suggested

By Kyle J. Norton

Scientists may have found a herbal medicine for the prevention and treatment of prostate cancer with no side effects, according to the studies.

Prostate cancer is a condition characterized by abnormal cells growth in prostate tissue.

Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Contrary to popular belief, as of today, prostate cancer no long is a disease of aging male, it has a tendency to affect the younger age population, particularly to that of age group 20 -40.

According to the statistic, most men diagnosed with prostate cancer survival or died due to another disease instead of prostate cancer. In the US, approximately over 2.9 million men in who have been diagnosed with prostate cancer at some point are still alive today.

Also, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and the disease is the most common cancer in American men.

Researchers do not know the exact causes of prostate cancer. Epidemiological studies suggested age, family history, being obesity or obese, genetic preposition, particularly a poor diet with high saturated and trans fat, red meat and processed food and low fruits and vegetables and whole grain are associated to the onset of prostate cancer.

Some researchers suggested ethnicity is a predictor involved the development of the disease due to a number of genetic mutations.

Dr. P Kheirandish said, "It is recognized that the risk of prostate cancer is higher in black men than in white men worldwide" and "...Compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries".

The results clearly proposed if you are black men, you are associated with a substantially higher risk of prostate cancer. However, if you follow a healthy diet and lifestyle, your risk of the prostate can be reduced compared to other men in the same race group.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.

The herbal medicine bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmitin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

The Korea Research Institute of Bioscience and Biotechnology, in the concern of mTOR Complex 2, a protein complex that regulates cellular metabolism may involve in the stimulation of the onset of prostate cancer, examined the effect of Aloe-emodin natural compound found in Cascara Sagrada and Aloe effect in prostate cancer cell line PC3.

Treatment of Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells through a number of mechanisms, including the regulation of cellular metabolism, proliferation, and migration.as well as tumor-promoting.

Furthermore, in vivo in an athymic nude mouse model, injection of Aloe-emodin also exhibited tumor suppression effects.

The finding strongly suggested Aloe-emodin suppresses prostate cancer progression by targeting mTORC2, a protein complex which plays an important role in prostate cancer development.

The examination of the Emodin (ED), an anthraquinone derivative found in Cascara Sagrada effect in inhibiting the proliferation, induce apoptosis, suppress angiogenesis, impede metastasis, and enhance chemotherapy, researchers investigated the mechanism of ED related to the regulation of gene expression that affects cellular migration and invasion in prostate cells.

In CXCR4/CXCL12 gene expression, involved in promoting invasion and metastasis in prostate tumor, injection of ED reduced the cancer proliferation and metastasis through inhibiting the CXCR4 expression.

Futhermore, researchers discovered, ED also reduced the expression of HER2 without affecting cell viability in tumor cells. 

Moreover, The suppression of CXCR4 expression by ED was found to correlate with the inhibition of CXCL12-induced migration and invasion of DU145, a human prostate cancer cell line.

Additional differentiation of the efficacy of ED, researchers also found the inhibition of the expression of CXCR4 was associated with the mRNA expression through a protein (NF-κB ) which controls the transcription of DNA, cytokine production and cell survival.

Dr.Ok S, the lead researcher wrote in the final report, "ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer".

Taken altogether, Herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive compound Aloe emodin and emodin may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of prostate cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Ethnic differences in prostate cancer by P Kheirandish1,2,* and F Chinegwundoh. (PubMed)