Herbal Bilberry, the Best Neuro-Protective Functional Remedy, According to Medical Literature

By Kyle J. Norton

Scientists may have found a herbal remedy which processes a neuron-protective effect against brain diseases, according to studies.

Neurological disorders are diseases associated with the brain, spine and nerves. In other words, they are diseases of the central nervous system.

There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetics preposition, and physical injury.

Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidant caused either by overexpression of free radicals or depletion of antioxidants enzymes or both.

Free radicals can be produced internally by normal cellular metabolism or from the external sources such as the air we breathe, smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.

In order for them to maintain stable, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not stop[ed until the outer ring electron is paired or inhibited by antioxidants.

Oxidative stress has been found to be a major risk for the onset of the neurological disorder in the Western world, particularly in North American.

Dr. Carvalho AN, the lead scientist in the assessment of oxidative stress and antioxidants in neurological diseases, said, "Oxidative stress is a pathological feature common to a multitude of neurological diseases. The production of reactive oxygen species (ROS) is the main mechanism underlying this cellular redox imbalance".

And, "overview of the main players in oxidative stress and outline evidence of their involvement in Parkinson's disease, Alzheimer's disease, Huntington's disease, and multiple sclerosis".

The results clearly suggested the impact of oxidative stress in the facilitation of the onset of neurodegenerative diseases.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Scientists on finding a natural ingredient which processes neuroprotective effects evaluated the activity of Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) against retinal damage.

According to the assays, in the retinal ganglion cells (RGCs) induced cell damage and radical activation by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1), injection of VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and free radical activation.

Furthermore, VMA also significantly inhibited the N-methyl-D-aspartic acid (NMDA)-induced morphological retinal damage compared to other derivatives. and increased apoptosis of the damage cells in the ganglion cell layer. 

Moreover, VMA at a concentration-dependently inhibited lipid peroxidation in mouse forebrain homogenates. In other words, VMA prevented the accumulation of lipid peroxidation in the neurons, the major cause of the neuron damage.

The findings suggested that VMA and its anthocyanidins process neuroprotective effects via an anti-oxidation mechanism in vitro and in vivo models of retinal diseases.

Additionally, in order to reveal more information about bilberry neuroprotective activity, researchers examined the antioxidants richly present in bilberry fruits effects on diabetes-related brain dysfunctions.

αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats before fed with an extract of bilberry fruit showed a reduction of swollen and the lengths of the neuronal fibers. 

Interestingly, diabetic rats fed with bilberry fruit showed a αCaMKII-positive nerve fiber significantly longer compared to the groups of diabetic and control rats. 

The results strongly suggested that bilberry fruits influence the morphology of and possibly exhibit beneficial and neuroprotective effects on hippocampal neurons during diabetes through the expression of antioxidants.

Taken altogether, bilberry processed abundantly bioactive compound such as anthocyanidin and its constituents cyanidin, delphinidin, and malvidin may be considered a functional remedy for the prevention and treatment of neuro-diseases, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)
(2) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(3) Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? by Carvalho AN1, Firuzi O2, Gama MJ3, Horssen JV4, Saso L. (PubMed)

Artichoke, The Best Reactive Oxygen Species Inhibitor, Researchers Find

By Kyle J. Norton 

Artichoke may be used as a natural ingredient to inhibit the overexpression of reactive oxygen species (ROS), according to studies.

Reactive oxygen species (ROS) or free radicals are highly reactive chemical species containing oxygen molecules. In other words, free radicals are unstable atoms with an unpaired electron in the outer ring.

Therefore, in order to become stable, free radicals must either donate or steal an electron from other atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.

Believe or not, free radicals in moderate amounts are needed for our body for cell signaling and activation of several transcriptional factors, apoptosis, immunity, and differentiation. However, overexpression of free radicles can cause damage to protein, lipid and cell alternation, leading a number of chronic illness, including cancer.

Free radicals are generated as metabolic by-products by biological systems. Environmental stressors (i.e., the air we breathe, UV, ionizing radiations, pollutants, and heavy metals) and xenochemicals are also found to contribute to the great increase of ROS production.

In a healthy individual, the production of free radicals is balanced by the antioxidant enzymes produced by the body.

Some researchers suggested that an unhealthy diet may also induce overexpression of free radicals through a number of mechanisms.

Dr. Vial G, the lead scientist said, "A high-fat diet results in both a decrease in mitochondrial quinone pool and a profound modification in mitochondrial lipid composition" and,  "These changes appear to play a key role in the resulting inhibition of fatty acid oxidation and of mitochondrial oxidative-phosphorylation associated with an increased mitochondrial ROS production".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural free radical scavenger evaluated the scavenging capacity against the most physiologically relevant reactive oxygen species (ROS) and reactive nitrogen species (RNS) of 3 artichoke extract from the leaves.

According to the tested assays, all extracts of artichoke leaves processed a remarkable capacity to scavenge ROS and RNS with IC50 values in a low μg/mL range (3.4-43μg/mL).

In HUVEC cells, preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 microg/mL for 24 h showed the complete inhibition of ROS generation induced by LPS which process biological effects on hosts infected with Gram-negative bacteria.

Where HUVEC cells are normally used for the study of the function and pathology of endothelial cells derived from the endothelium of veins from the umbilical cord.

Injection of the extracts also inhibited the lipid peroxidation in the tested HUVEC cells.

Artichoke also reduced the cell apoptosis caused by free radicals damage by inhibiting the ROS generation and reducing the function of cytochrome c, a component of the electron transport chain in mitochondria in triggering programmed cell death through apoptosis.

Taken altogether, artichoke may be considered a free radical scavenger for the prevention and treatment of diseases associated with oxidative stress, pending to the result of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynaracardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS by Pistón M1, Machado I1, Branco CS2, Cesio V3, Heinzen H3, Ribeiro D4, Fernandes E4, Chisté RC5, Freitas M. (PubMed)
(2) The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells by Juzyszyn Z1, Czerny B, Pawlik A, Droździk M. (PubMed)
(3) Effects of a high-fat diet on energy metabolism and ROS production in rat liver by Vial G1, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, Athias A, Galinier A, Casteilla L, Leverve XM. (PubMed)

3,3'-Diindolylmethane, the Potential Anti Prostate Cancer Bioactive Compound, According to Researchers

By Kyle J. Norton

Scientists may have found a plan based bioactive compound for the treatment of prostate cancer with no side effects, according to studies.

Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.

The disease often is discovered during the rectum examine annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.

In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, frequent and urged urinary.

In severe cases, prostate cancer can also cause erectile dysfunction.

According to statistic, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.

Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.

Out of many risk factors, unhealthy diet may be one of the major risk factors associated with the onset of the disease.

Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".

" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".

"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).

Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.

Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.

In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cell by targeting the mRNA of miR-150-5p in prostate cancer cells.

Moreover, in order to reveal more information of DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer protective food bioactives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).

Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.

In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.

I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.

Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'. 

The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.

Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.

Intake of DIM in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)

Artichoke Inhibits the Risk and Progression of Hepatic (Liver) Fibrosis, Researchers Reveal

By Kyle J. Norton

Artichoke may be used as a natural remedy for the treatment of hepatic fibrosis with no side effects, according to studies.

Hepatic fibrosis is a chronic liver disease due to liver scars overwhelmingly building up in the connective tissue in the liver.

The severe case of hepatic fibrosis can lead to cirrhosis, affecting the liver function in filtering the blood. In the US, over 4.5 million people are affected by liver cirrhosis, leading to the death 12/100,000 of the population every year.

Most common causes of liver fibrosis are excessive alcohol drinking and infected by the hepatitis virus.

Other risk factors associated with the prevalent risk liver fibrosis are non-alcoholic steatohepatitis and autoimmune liver disease, including autoimmune hepatitis, primary biliary cirrhosis or primary sclerosing cholangitis.

However, the increase in age may also have a strong implication on the disease onset.

Dr. Bénédicte Delire, the lead scientists, in the concern of liver fibrosis in the aging mice population said, "Old mice developed more severe fibrosis compared to young ones as evaluated by Sirius red morphometry" and " While fibrosis resolution occurred in young mice within 96 hours, no significant fibrosis attenuation was observed in old mice".

"Although recruitment of monocytes-derived macrophages was similar in young and old livers, young macrophages had globally a remodeling phenotype while old ones, a pro-fibrogenic phenotype".

The results suggested that the elderly are associated with the more severe fibrosis, due to the weakened  immune system

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural compound for the treatment of hepatic fibrosis, before the excessive connective tissue builds up in the liver progressing to chronic liver diseases such as cirrhosis and liver cancer examined the liver protective effect of artichoke against the liver fibrosis.

The study included 12 groups of rats were administered JAT, interferon, and ribavirin either separately or in combination from day one of CCL4 administration until the end of the study.

Observation of the killed animals after 8 weeks, CCL4- induced hepatotoxicity exerted a significant increase level of hepatic protein expression levels associated with cell cycle arrest through the function of tumor suppressive activity.

Furthermore, the levels of enzymes and protein associated with cell apoptosis such as p53, BAX, and TGF-β also were also increased in CCL-4 induced hepatotoxic rat group.

Injection JAT rats not only exerted a strong effect in normalizing the function of proteins and enzymes in the induction of liver cell death but also improved the liver response to ribavirin and interferon used for the treatment of HCV infection.

Dr. Abdel-Hamid NM and colleagues in the final report wrote, "addition of JAT as a supportive regimen to interferon and ribavirin effectively potentiates their anti-fibrotic effects".

Moreover, the observation of four mice groups infected with parasite S. mansoni with the first three groups received ALE, ALE + PZQ and PZQ respectively compared to the 4th and 5th group acted as the positive control and negative control, respectively suggested that ALE caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis. 

The efficacy of ALE was attributed to the increase the hepatic stellate cells (HSCs) recruitment inside granuloma associated with the liver response to infection, inflammation, or the presence of a foreign substance, and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.

However, in spite of the ALE liver protective activity against the formation of liver fibrosis and increased liver functioning, ALE showed no effect against parasite infection.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver fibrosis depending on the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats by Abdel-Hamid NM1, Wahid A, Nazmy MH, Eisa MA. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling by Bénédicte Delire,1 Valérie Lebrun,1 Charlotte Selvais,1 Patrick Henriet,2 Amélie Bertrand,1Yves Horsmans,1,3 and Isabelle A. Leclercq. (PMC)

Can Herbal Alfalfa Be Used for the Prevention and Treatment of Cancers?

By Kyle J. Norton

 Scientists do not agree that herbal Alfalfa can be used alone or combined with other primary medicine for the treatment of cancer, according to study.

Cancer is a class of diseases characterized by the cell growth irregularly and disorderly in the body tissue.

Most cases of cancer start in the cell on the surface of the inner lining of the tissue of the organ. In the early stage, due to the small size of the tumor, most patients do not experience any symptoms.

However, in the advanced stage, most cancer can cause bleeding and serious pain if the large size has pressed on the blood vessels and nearby nerve cells. In this stage, cancerous cells may travel a distance away from the original site to infect other tissue and organs, leading to secondary metastasis.

Researchers do not know what causes cancer? but epidemiological studies suggested that genetic mutation inherited from the parent and acquired genetic alternation due to smoking, radiation, viruses, carcinogens, are associated with the onset of the diseases.

Some researchers also strongly indicated obesity-induced hormones change and, chronic inflammation is a major risk factor involved the development of cancers in the Western world 

Dr. Karen Basen-Engquis, the lead scientist in the cancer team wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity".

And, "Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".

These results clearly suggested reducing weight through diet and exercise or surgery may be the best way for attenuating the risk of cancer onset.

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds have been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc.

North America aboriginal has used Alfalfa seed as food, such as making bread and mush.

It chemical constituents include flavones, isoflavones, sterols, Bichanin A Coumestrol Diadzein Formonetin Genisteincoumarin derivatives, etc.

With an aim to find the natural ingredient or herbal remedy, researchers looked into L-Canavanine, a potentially toxic antimetabolite of L-arginine stored by sprouts, and in ten varieties of the seed of alfalfa, against a number of animal-bearing carcinomas and cancer cell lines.

The young plant exerted the strongest anti-cancer effects measured by the stored appreciable canavanine ranged from 1.3 to 2.4%, compared to that 1.54 of the seed.

Alfalfa seed canavanine content levels were also found in the seeds of other members of the genus Canavalia, which are amongst the more abundant sources of this antimetabolite.

Dr, Watanabe K, and colleagues in the examining anti-colon cancer effect of dietary alfalfa, pectin, and wheat bran in female inbred F344 rats by given at 7 weeks of age, a dose of azoxymethane (AOM) of 8 mg/kg body weight/week for 10 weeks or methylnitrosourea (MNU) intrarectally at a dose rate of 2 mg/rat twice a week for 3 weeks.sugegsted

Examine the results from the autopsies at the 40 weeks and the MNU-treated group 30 weeks after the first injection of the carcinogen, showed no tumors in the colon or other organs of untreated rats fed the various diets. 

The animals fed the alfalfa diet and treated with MNU had a higher incidence of colon tumors than did those fed the control diet or the diets containing pectin or wheat bran. 

The incidence of MNU-induced colon tumors did not differ between the animals fed the control diet or the diets containing pectin or wheat bran.

The incidence of AOM-induced colon tumors in rats fed diets containing pectin or wheat bran was lower than that in rats fed the control diet or the alfalfa diet. 

These results clearly suggested that the effect of fiber in colon carcinogenesis depends on the type of fiber and, possibly, the fiber's mode of action.

Taken altogether, the conflict results indicated that further studies are necessary before herbal Alfalfa can be used for the prevention and combined with other therapy for the treatment of cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The natural abundance of L-canavanine, an active anticancer agent, in alfalfa, medicago sativa (L.). by Rosenthal GA, Nkomo P.(PubMed)
(2) Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. by Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D.(PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

Bilberry Modulates the Expression of Energy Metabolism, According to Scientists

By Kyle J. Norton

Bilberry may be the next potential target by the pharmaceutical companies to extract a single ingredient medicine for improvement of energy metabolism, according to studies.

Energy metabolism is a process to generate energy from protein, fat and carbohydrate or fat already stored in the body.

Although carbohydrates and fat are considered the major sources of energy in the diet, protein is necessary for all kinds of biological processes but less in the direct production of energy purposes.

Energy metabolism alterations are found associated with a large number of diseases including mitochondrial diseases, acute coronary syndrome, chronic kidney disease, asthma or even cancer. 

And, energy metabolism alternation can also affect all organs and tissues functioning.

Certain factors can increase and decrease the rate of energy metabolism, such as the immune cells require energy to maintain cellular viability and to perform specific immune functions, including

* Body size such as weight and heigh

* Body composition: fat tissue has a lower metabolic activity than muscle tissue.

* Aging: decrease muscle mass decrease energy metabolism.

* Gender women have a slow rate of energy metabolism compared to men.

Dr. Prabhakar, the lead scientist in the investigation of the energy metabolism on obesity, said, "Energy used by the body is described in terms of the metabolic rate underlying passive and active conditions which are further correlated to body weight".

And, "Energy metabolism and the role of carbohydrates, lipids, and protein in foods are areas of emerging research with a therapeutic approach against obesity and related biological disorders". of e

The results strongly suggested that if you are obese, you are at higher risk of diseases associated with decreased rate of energy metabolism, such as insulin resistance.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding the natural ingredient for the improvement of energy metabolism investigated the bilberry activity in genes expressed in the intestinal mucosa which is responsible for nutrient absorption and waste secretion.

Injection of bilberry improved the intestinal barrier functioning by enhancing the balance of gut microbiota, thus increasing the nutrients absorption.

Furthermore, male C57BL/6J mice (n = 52) selected to the study received a control low-fat diet (LFD; 10 kcal% fat) for 6 weeks followed by 24 weeks of either LFD (n = 13) or high-fat diet (HFD; 45 kcal% fat; n = 13) or HFD supplemented with 0.1% w/w of the flavanol compound epicatechin (HFD+E; n = 13) or an anthocyanin-rich bilberry extract (HFD+B; n = 13), researchers found that

* The switch from an LFD to an HFD increases the plasma cholesterol and hepatic lipid content in non-anthocyanin-rich bilberry extract treatment group.

* The polyphenol compounds in the HFD supplemented with 0.1% w/w of the flavanol compound epicatechin could not prevent HFD-induced systemic rise of inflammatory levels compared to the bilberry treatment group.

* The findings strongly supported the use of supplementation of HFD with an anthocyanin-rich bilberry extract for the beneficial effects on the systemic early inflammatory response associated with HFD-induced obesity.

Dr. the leads scientist wrote, "On the tissue level, long-term treatment with bilberry attenuated TNF-α expression in adipose tissue".

In other words, the intake of anthocyanin-rich bilberry extract lowers the level of systemic inflammation in the adipose tissue against the onset of metabolic syndrome-associated chronic pathologies.

Taken altogether, bilberry may be considered a functional remedy to improve the intestinal barrier functioning in energy metabolism by reducing the intestinal inflammation and promoting healthy adipocytes.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M8. (PubMed)
(2) Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity. by van der Heijden RA1, Morrison MC2, Sheedfar F3, Mulder P4, Schreurs M5, Hommelberg PP6, Hofker MH7, Schalkwijk C8, Kleemann R2, Tietge UJ5, Koonen DP7, Heeringa P. (PubMed)
(3) 6 - Protein, Carbohydrates, and Fats: Energy Metabolism by Prabhakar Singh, Rajesh K.Kesharwani, Raj K.Keservani. (Science Direct)

Honey, the Best Remedy for the Prevention and Treatment of Reflux Esophagitis

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of reflux esophagitis, some studies found.

Acid Reflux or heartburn is a condition characterized by the going back up of acidic stomach contents to the esophagus. Most cases of acid reflux are happened immediately after eating causing a burning sensation or pain in the lower chest area.

According to the statistics, in the US, approximately, 20% of people with acid reflux will develop gastroesophageal reflux disease (GERD). More than 65% of people who suffer from acid reflux are 40 years old or older. And, 15 to 30 5 of the U.S. population has GERD.

Too much tea, coffee, and alcohol smoking pregnancy, obesity, eating habits such as eating close to bedtime, eating a large meal, eating fatty and fried foods are some of the risk factors that initiate to the early onset of acid reflux, according to the epidemiological studies.

Believe it or not, long-term intake of certain medication such as bronchodilators for asthma, progestin for birth control or to treat abnormal menstrual bleeding, sedatives for insomnia and anxiety, calcium channel blockers for high blood pressure.

Dr. Zeynel Mungan and colleagues in examing the medication risk of GERD wrote, "Gastroesophageal reflux disease (GERD), which is common in many communities, is associated with structural factors, eating habits, and the use of certain drugs".

And, "The use of such drugs can lead to the emergence of GERD and can also exacerbate existing reflux symptoms. These drugs can contribute to GERD by directly causing mucosal damage, by reducing lower esophageal sphincter pressure (LESP), or by affecting esophagogastric motility".

Therefore, if you currently taking some of the aforementioned medication, please make sure that you know all the side effects for preventive measure.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Scientists on the finding a natural remedy for the treatment of acid reflux investigated the honey effect on reflux oesophagitis (RE).

Injection honey displayed a strong effect on reflux oesophagitis through inhibiting the free radical expression which has been found to be mediators in the generation of RE.

Furthermore, besides inhibiting the over expression of free radicals, honey also promoted the production of antioxidants enzymes in the host, leading to the balanced ratio of free radical and antioxidant in the body. 

Moreover, honey injection also reduced the levels of inflammation by inhibiting the nitric oxide and prostaglandin E2 production associated with free radical and inflammation, respectively.

The effects of honey against RE also attributed to the nature of high density, high viscosity, and low surface tension, that make them stay longer in the esophagus as a coating on the mucous membrane.

Additionally, researchers also found that the anti-RE activity of honey was also due to its nonperoxide antibacterial activity.

The findings suggested honey inhibits the onset of progression RE through a number of mechanisms, including proteins associated with the production of pro-inflammatory cytokines and antioxidant enzymes produced by the honey and the host.

Taken altogether, honey may be considered a functional remedy for the prevention and combined with the primary therapy for the treatment of reflux esophagitis.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Honey - A nutrient with medicinal property in reflux oesophagitis by Mahantayya V. Math,* Rita M. Khadkikar, and Yashoda R. Kattimani. (PubMed)
(2) Which drugs are risk factors for the development of gastroesophageal reflux disease?  by Zeynel Mungan, Binnur Pınarbaşı Şimşek. (University School of Medicine and İstinye University School of Medicine)