Herbal Arctostaphylos uva-ursi, the Anti Diabetes Functional Remedy

By  Kyle J. Norton

Scientists may have found a medicinal plant for the treatment of diabetes with no side effects, according to the studies.

Diabetes is a medical and chronic condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes is a result of abnormally and chronically high levels of sugar (glucose) in the blood. Insulin resistance is a hallmark of diabetes. The disease is either caused by cells in pancreas died off or receptor sites clogged up by fat and cholesterol.

Insulin receptors are areas on the outer part of a cell that allow the cell to bind with insulin in the blood. When the receptors are clogged up, the cell can not take glucose (sugar) from the blood and use it for energy.

Researchers do not know what causes insulin resistance in diabetic patients. However, researchers do know that long-term intake of a poor diet with high saturated and trans fat, red meat and processed food is one of many risk factors associated with clogged up the insulin receptors sites, leading to high blood glucose.

Dr. David Hefner in the concern of the Western diet linked to type 2 diabetes, wrote, "The researchers surveyed 42,000 men over a 12-year period. The men's eating habits were divided into two groups: those who followed a Western diet and those who followed a "prudent" diet with fruit, vegetables, whole grain, fish and poultry. "Over the course of the study ... 1,321 new cases of Type 2 diabetes were diagnosed".

These results clearly suggested that by changing to a healthy diet pattern with high fruits and vegetables and reducing the intake of saturated and trans fat, red meat and processed food, diabetes is preventable.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and for the treatment of urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

On finding a natural formula for the treatment of diabetic symptoms that leads to the investigated 7 plants and a herbal mixture used for the traditional treatment of diabetes in streptozotocin diabetic mice conducted by the University of Ulster.

In streptozotocin diabetic mice, the formula was supplied as 6.25% by weight of the diet for 9 days.

The consumption of diets containing bearberry (Arctostaphylos uva-ursi), significantly reduced the excessive hunger and abnormally large intake of solids and excessive thirst or excess water drinking associated with streptozotocin diabetes.

However, other herbal plants in the herbal formula such as bayberry (Cinnamomum tamala), meadowsweet (Filipendula ulmaria), Senna (Cassia occidentalis) and the herbal mixture did not alter these parameters.

Bearberry, mistletoe, and tarragon retarded body weight loss, reduced symptoms of diabetes without significantly altered plasma glucose or insulin concentrations.

The results suggested that only bearberry, goldenseal, mistletoe, and tarragon can counter some of the symptoms of streptozotocin diabetes without affecting glycemic control.

Taken altogether, bearberry (Herbal Arctostaphylos uva-ursi) may be used as a functional remedy for the  treatment of some diabetic symptoms, pending to the confirmation of large sample size and multicenter in a human study




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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR.(PubMed)
(2) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)

Herbal Aloe vera, the Anti Primary Glioblastoma Functional Remedy

By Kyle J. Norton

Aloe vera may process a strong implication in reducing the risk of primary glioblastoma, according to studies.

Primary glioblastoma is considered the most aggressive cancer that begins within the brain. Cancer may arise de novo, meaning they begin as a Grade IV tumor with no evidence.

According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.

Due to the rapid growth of the tumor, patients diagnosed with primary glioblastoma experience brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, and severe headaches and localized symptoms depending on the location of the tumor.

Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery. 

Increased in age, and genetic preposition are the 2 most common risk factors of the diseases. Dr. Athanassios P. Kyritsis, in the concern of the rapid progression of glioblastoma, wrote, "Scientific evidence during the last few years has revealed several constitutive genetic abnormalities that may influence glioma formation".

And, "These germline abnormalities are manifested as either gene polymorphisms or hemizygous mutations of key regulatory genes that are involved either in DNA repair or in apoptosis".

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.


The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.

Researchers on the finding a natural compound for the treatment of cancer examined the anti-brain cancer effect of Aloe-emodin isolated from the leaves of Aloe vera in human U87 malignant glioma cells.

Injection of Aloe-emodin exerted a significant apoptotic activity and induced proliferation in a time- and dose-dependent.

The percentage of viable U87 cells was also deceased substantial via the induction of apoptosis.

The formation of apoptotic bodies was observed by the confocal microscope by Annexin V-FITC/PI staining. 

Aloe-emodin inhibits the human U87 malignant glioma cells, was attributed to the arrested the cell cycle in the S phase and promoted the loss of mitochondrial membrane potential in U87 cells.

In order to reveal the inhibitory efficacy mechanisms of Aloe-emodin against human U87 malignant glioma cells, researchers at the University of South Florida, Tampa, examined the effects of the bioactive compound through the aspects of the cell cycle, cell proliferation and protein kinase C (PKC) during glioma growth and development.

In cell cycle arrest, according to the flow cytometry assay, Aloe-emodin delayed the number of cells entering and exiting DNA synthesis (S) phase in both SVG and U-373MG cells, a strong indication that Aloe-emodin may inhibit S phase progression.

In cell viability assay, SVG and U-373MG glioma cell were highly sensitive to the application of Aloe-emodin.

Furthermore, injection of Aloe-emodin-induced decreased proliferation,  sustained at 48-96 hours.

Exposure of SVG and U-373MG glioma cells to aloe-emodin suppressed PKC activity in the promotion of cancer cell proliferation by reduced the protein content of most of the PKC enzymes.

Moreover, Aloe-emodin inhibited cancer growth was also associated with the activation of a protein in programming cell death.

Taken altogether, herbal Aloe vera processed a major bioactive compound Aloe-emodin may be considered a functional remedy for the prevention and combined with primary therapy for treatment of brain cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin by Ismail S, Haris K, Abdul Ghani AR, Abdullah JM, Johan MF, Mohamed Yusoff AA.(PubMed)
(2) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells by Acevedo-Duncan M, Russell C, Patel S, Patel R.(PubMed)
(3) Inherited predisposition to glioma by Athanassios P. Kyritsis, Melissa L. Bondy, Jasti S. Rao, and Chrissa Sioka. (PMC)

Herbal Arctostaphylos uva-ursi, the Potential Anti Gastric/ Stomach Cancer Remedy

By Kyle J. Norton

Scientists may have found a herbal remedy for the prevention and treatment of gastric cancer with no side effects, according to studies.

Gastric cancer or stomach cancer is a condition characterized by the abnormal growth of cells in the stomach tissue.

Most cases of gastric cancer start in the cells on the surface of the inner lining of the stomach tissue.

At stage 0, due to the gastric cancer cells was restricted or completely contained within the innermost layer of the lining, patients may not experience any symptoms.

However, at the later stage, the cancer cells can travel a distance away from the stomach to infect other tissue and organ, leading to secondary metastasis. If the tumor grows large enough, it may suppress the nearby blood vessels and nerve cells, causing blood leaked into the stomach and localized severe pain.

Besides common symptoms of cancers, patients with gastric cancer also experience some specific symptoms such as persistent abdominal (belly) pain., vague discomfort in the abdomen, a sense of fullness in the upper abdomen after eating a small meal and heartburn or indigestion.

If you are having some of the above symptoms, please check with your doctor to rule out the gastric cancer possibility.

Although there are many risk factors involved in the onset of the disease, such as family history, Helicobacter pylori infection, smoking, genetic preposition, certain stomach conditions, previous stomach surgery and type A blood, some researchers suggested that most common cause of gastric cancer in the Western world is the Western diet-related disease.

Dr. Bertuccio P, the lead scientist at the Istituto di Ricerche Farmacologiche Mario Negri, in the concern of diet pattern in the risk of gastric cancer wrote, " An unfavorable role on GC emerged for the 'Western/unhealthy' dietary pattern, with an OR of 1.51 (95% CI: 1.21-1.89)" and "A favorable role on GC emerged for the 'Prudent/healthy', with an odds ratio (OR) of 0.75 [95% confidence interval (CI): 0.63-0.90], for the highest versus the lowest category".

The results strongly indicated the risk of gastric cancer is substantially higher in the Western diet group compared to the lower risk of a healthy diet.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb plant has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

The plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

With an aim to find a natural ingredient or whole food for the treatment of gastric cancer, researchers at the Shanghai University of Traditional Chinese Medicine examined the effects of ursolic acid isolated from bearberry (Arctostaphylos uva-ursi) against the pathogenesis of gastric cancer characterized by excessive proliferation, abnormal differentiation, and reduced apoptosis.

Ursolic acid, extracted from traditional Chinese medicine bearberry, inhibited gastric cancer cell proliferation and induced apoptosis.

Further assessment of anti-gastric cancer, researchers discovered that ursolic acid exhibited apoptotic activity through cancer cell degradation observed in the gastric cancer BGC-823 cells.

In other words, the efficacy is associated with a translocation of cofilin-1 protein that activates the function of cytochrome c in program cell death from the mitochondria to the cytoplasm.

These results suggested that ursolic acid activated the function of proteins (the caspase cascade) associated with the cell death and apoptotic pathway.

Where Mitochondria are the major organelles involved in the biochemical execution of apoptosis

Dr. the lead scientist, after taking into account co and confounders said, "mitochondrial translocation of cofilin-1 might play a crucial role in the promotion of apoptosis and might be a key target for future treatment of human gastric cancer".

Taken altogether, Bearberry (herbal Arctostaphylos uva-ursi) processed a major compound of ursolic acid may be considered a functional remedy for the prevention and combined with other primary medicine for the treatment of gastric cancer, pending to the confirmation of large sample size and multicenter human study.

However, intake of ursolic acid as a supplement should be taken with extreme care to prevent overdoses acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid by Tang Q, Ji Q, Tang Y, Chen T, Pan G, Hu S, Bao Y, Peng W, Yin P.(PubMed)
(2) Dietary patterns and gastric cancer risk: a systematic review and meta-analysis by Bertuccio P1, Rosato V, Andreano A, Ferraroni M, Decarli A, Edefonti V, La Vecchia C. (PubMed)

Herbal Aloe Vera Improves the Function of Immune System with No Side Effects

By Kyle J. Norton

Scientists may have found a natural ingredient for the enhancement of the immune system with no side effects, according to studies.

The immune system is the set of cells associated with the activity against antigens or infectious agents.
It is one of the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

Immune dysfunction is a chronic condition, depending on the parts of the immune system affected.

There are 2 types of immune dysfunction. The underactive immune system is also known as weakened immune system  People with the underactive immune system are susceptible to infection, recurrent infections, autoimmune disorders, damage to heart, lungs, nervous system or digestive tract, increased risk of cancer, malnutrition, and death from serious infection.

On the other hand, the active immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system attacks the body tissue.

Immunomodulation is a process in which an immune response is altered to the desired level. In other words, under the immunomodulatory effect, the immune system is responding correctly to the desire of the body, regardless of types of immune dysfunction.

Dr. Jeffrey A. Bluestone, the lead scientist in the study "Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases" wrote, "Considerable progress has been made in the immunomodulation of autoimmune diseases and the understanding of the complex molecular and cellular pathways targeted by novel treatments".

And "... a number of immunotherapies have become the standard of care and greatly improved the clinical outcome and quality of life of patients with some autoimmune diseases".

These results strongly suggested that immunomodulation can be used for the prevention and treatment of under and overactive immune function.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.

The herbal plant has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.


With an aim to find the pharmacological potential of Aloe arborescens Miller leaf components against the immune dysfunction, researchers examined the to immune modulatory effects on the Sparus aurata fibroblast cell line SAF-1.

According to the application of Aloe extract at different concentrations (1.2-4.8 mg ml(-1)) for various times (24-72 h) for the treatment of the cells, the lowest concentration did not provoke any cellular damage observable by SEM and did not affect ATP amounts after 24 and 48 h, while even induced a significant increase over controls after 72 h.

However, the Aloe extract at a concentration of 1.2 mg ml(-1)) exerted a powerful immune stimulation in exhibiting an effect on interconnected genes in the SAF-1 cells involved in different aspects of the immune responses.

Researchers at the end of the experiment wrote, "A. arborescens to prevent or oppose bacterial and viral fish diseases and to face, as an alternative strategy based on natural plant extracts, the growing unwillingness to rely upon standard solutions involving antibiotics or antimicrobial chemicals".

Further, the investigation of the effect of an aloe polymannose multi-nutrient complex (APMC) formula on cognitive and immune functioning over 12 months among adults diagnosed with AD.

The participants were given to 4 teaspoons of the formula per day. The results were assessed at baseline and 12 months.

The formula demonstrated a significantly improved at 9 and 12 months compared to baseline, and 46% of our sample showed clinically-significant improvement (≥4-point change) from baseline to 12 months, according to the mean ADAS-cog cognition score.

Participants showed a significant decrease in protein associated with immune response in the activation of proinflammatory cytokines with few, temporary adverse reactions.

In other words, the formula displayed strong immune modulatory effects in regulating the immune responses on patients with AD.

Taken altogether, herbal Aloe vera mMedical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Healthay be considered a functional remedy in regulation and adjustment of the immune system against stimuli, including allergens, infectious pathogens with no side effect.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(3) The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. by Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R, Ferro VA.(PubMed)
(4) Immune modulatory effects of Aloe arborescens extract on the piscine SAF-1 cell line. by Picchietti S, Bernini C, Belardinelli MC, Ovidi E, Taddei AR, Guerra L, Abelli L, Fausto AM.(PubMed)
(5) The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease. by Lewis JE, McDaniel HR, Agronin ME, Loewenstein DA, Riveros J, Mestre R, Martinez M, Colina N, Abreu D, Konefal J, Woolger JM, Ali KH.(PubMed)
(4) Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases by Jeffrey A. Bluestone and Hélène Bour-Jordan. (PMC)

Herbal Aloe Vera, the Potential Anti Prostate Cancer Functional Remedy

By Kyle J. Norton

Herbal Aloe vera may be used for the prevention and treatment of prostate cancer with no side effects, some scientists suggested.

Prostate cancer is slow-growing cancer characterized by irregular cell growth in the prostate tissue.

Most cases of prostate cancer start in the cells on the surface of the inner lining tissue. However, at
the advanced stage, cancerous prostate cells can travel a distance away to infect other healthy tissue and organs, causing the secondary metastasis. Most often, prostate cancer spreads to the bones or lymph nodes.

Most prostate cancers may be detected during the physical (rectum) exams.

According to the statistic, 1 man in 9 will be diagnosed with prostate cancer during his lifetime. 6 cases in 10 are diagnosed in men aged 65 or older and the average age at the time of diagnosis is about 66.

The 5-year survival rate for most men with stage 0 and 1 prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years.

These results strongly indicated that men who are at a higher risk of prostate cancer due to family history and genetic proposition should have a prostate exam taken every year.

Besides aging, other most common risk factors of prostate cancer include family history, ethnicity, genetic preposition, exposure to agent orange and eating habits.

Dr. Wambui G. Gathirua-Mwangi, the lead author in the cancer team in the joint study led by the Indiana University, wrote, "Epidemiologic studies have overall showed that the habitual consumption of a diet high in saturated fat, well-done meats, and calcium is associated with an increased risk of advanced prostate cancer".

And, "measure the nutrients and their biochemical indicators, the risk of advanced prostate cancer, which is fatal and thus clinically significant, may be reduced by dietary modification or chemoprevention".

The finding strongly indicated a healthy diet high in fruits and vegetables and whole grain and low in

saturated and trans fat, red meat and processed foods have a decreased risk of prostate cancer.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.


The ten main areas of chemical constituents of Aloe vera include Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

On finding a natural compound or ingredient for the treatment of prostate cancer with no side effects, researchers at the Korea Research Institute of Bioscience and Biotechnology evaluated phytochemical Aloe-emodin, a bioactive compound isolated from the Aloe vera against prostate cancer on the protein

Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells. 

The efficacy of the inhibited was found to involve proteins that exhibit androgen-refractory prostate cell proliferation and anchorage-independent growth through cancer cell metabolism.

Furthermore, Aloe-emodin demonstrated a significant effect against the activation of a protein (mTORC2) in stimulating the cancer cell proliferation and migration.

Interestingly, researchers also found that Aloe-emodin also inhibits the gene associated with tumor promoter, namely Protein kinase C alpha (PKCα).  

Expression of protein kinase C alpha (PKCα) has a strong implication in cancer metastasis and poor prognosis.

In other words, Aloe-emodin displays significant anti-prostate cancer properties by inhibiting cancer cell proliferation, migration through binging to proteins associated with them.

In vivo, Aloe-emodin also exhibited tumor suppression effects in an athymic nude mouse model.

Dr. Liu K after taking into account co and confounders said, "aloe-emodin suppresses prostate cancer progression by targeting mTORC2".

Taken altogether, herbal Aloe vera may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of prostate cancer with no side effect, pending to the confirmation of large sample size and multicenter human study.

Intake of supplement Aloe-emodin should be taken with extreme care to prevent overdoses induced acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)

Herbal Aloe Vera, the Anti Skin Aging Functional Remedy with NO Side Effects, According to Studies

By Kyle J, Norton

Scientists may have found a natural and potent herbal plant used for the delay of skin aging, according to the studies.

Skin aging is a natural and biological process of the human which can be stopped.

Long-term free radical damage to the skin through oxidative stress is the major cause of skin aging.

Exposure to the sun (photoaging) and pollution, and loss of subcutaneous support (fatty tissue between your skin and muscle) are some of the risk factors associated with the skin aging.

Some researchers suggested that skin expression may be considered as a refect of the general health of an individual. An unhealthy skin due to skin nutritional deficiency has been a target by the dermatology and cosmetic industries.

Dr.Silke K. Schagen in the study that links between nutrition and skin aging, said, "Vitamins, carotenoids, tocopherols, flavonoids and a variety of plant extracts have been reported to possess potent antioxidant properties and have been widely used in the skin care industry either as topically applied agents or oral supplements in an attempt to prolong youthful skin appearance".

The results strongly suggested that by providing enough nutrition to the skin needs, extrinsic causes of skin aging can be delayed

In skin wrinkle, according to the results of the studies by the Monash University, Melbourne, a high intake of certain food groups are associated with the speeding up of wrinkle, including meat, dairy, and butter. High intake of vegetables, legumes and olive oil appeared to be protective against cutaneous actinic damage.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.


The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

With an aim to find a natural ingredient or whole food for the delay of skin aging researchers at the Seoul National University Boramae Hospital examined the effect of aloe gel on the clinical signs and biochemical changes of aging skin.

The experiment included 30 healthy female subjects over the age of 45 given 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days with their baseline status as a control.

Aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group.

The injection of the gel also increased the skin photoprotection and the type I procollagen mRNA levels in controlling the rate of procollagen synthesis.

The results were accompanied by the matrix (MMP-1) mRNA levels associated with the breaking down the interstitial collagens, types I, II, and III, particularly in the higher-dose group.

Type I procollagen was substantially increased throughout the dermis in Aloe treatment of the group.

Dr. Cho S, the lead scientist said, "Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression".

The Kyung Hee University Global Campus in the investigation of the effects of Aloe vera on ultraviolet (UV) irradiation induces photo-damage of the skin, which in turn causes depletion of the dermal extracellular matrix and chronic alterations in skin structure.

By the comparison of the baby Aloe shoot extract (BAE, immature aloe extract), which is from the one-month-old shoots of Aloe vera, and adult aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, protective effect on UVB-induced skin photoaging in normal human dermal fibroblasts (NHDFs). researchers found that NHDF cells treated UVB-irradiation suppressed the matrixes associated with the breaking down the interstitial collagens, types I, II, and III, and the levels of inflammatory cytokines similar to that of the above study, compared to the AE-treated cells.

BAE treatment elevated type I procollagen which was reduced in photodamaged skin. mediated by the increasing levels of TGF-β1 levels which is a multifunctional cytokine.

The findings clearly suggested that herbal Aloe vera may be considered an anti-aging functional remedy with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH. (PubMed)
(2) A Comparative Study of Baby Immature and Adult Shoots of Aloe Veraon UVB-Induced Skin Photoaging in vitro. by Hwang E, Kim SH, Lee S, Lee CH, Do SG, Kim J, Kim SY. (PubMed)
(3) Innovations in natural ingredients and their use in skin care.
(4) Discovering the link between nutrition and skin aging by Silke K. Schagen, † Vasiliki A. Zampeli,  † Evgenia Makrantonaki,  and Christos C. Zouboulis. (PMC)
(5) Skin wrinkling: can food make a difference? by Purba MB1, Kouris-Blazos A, Wattanapenpaiboon N, Lukito W, Rothenberg EM, Steen BC, Wahlqvist ML. (PubMed)
(6) Prevalence of Helicobacter pylori Infection in Patients with Peptic Ulcer Diseases and Non-Ulcer Dyspepsia by Hyo Rang Lee, M.D., Ki Soo Han, M.D., Byung Chul Yoo, M.D., and Sill Moo Park, M.D. (PMC)

Herbal Aloe Vera, the Promising Topical Wound Healing Functional Remedy, Researchers Say

By Kyle J. Norton

Herbal aloe vera may be used for speeding up the skin wound healing with no side effects, some researchers suggested.

Wound healing is the natural process of repair of skin damage and injury.

The process of skin healing in human is gone through several stages. First, the immune system after sensing the skin wound activates the immune first line defense stimulating the constriction of the blood vessel to reduce blood flow, activate platelets, and many different clotting factors to cover the wound area.

Then, the white blood cells also up-regulate the proteins associated with the production of proinflammatory cytokines to the site of infection to kill off all the invasive organisms.

In most cases, due to overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.

Furthermore, the production of pro-inflammatory cytokines in some case can cause the death of nearby healthy cells, leading to the formation of irreversible scars, as seen in the liver.

After the inflammatory phase, the new blood vessels are formed and the new granulation tissues are built.

The final phase of the wound healing is involved in the remodeling of collagen from type III to type I cellular activity reduces.

If the process of skin healing is interrupted, it may lead to abnormal cell membrane repair, a major cause of skin scars.

MG53 is a protein involved in tissue repair and regeneration and also considered a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing. The defection and down-regulation of MG53 protein may delay wound healing and abnormal scarring.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.

It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

On finding the natural compound or remedy for speeding up the treatment of wound healing, researchers examined the efficacy of aloe vera through searching the data of online medical literature.

Only controlled clinical trials for burn healing were included. There were no restrictions on any language of publication. Only 4 Four with a total of 371 patients were included in this review.

According to the meta-analysis using the duration of wound healing as an outcome measure, the healing time of the aloe vera group was 8.79 days shorter than those in the control group.

The cumulative evidence support that aloe vera can be an effective intervention used in burn wound healing for first to second-degree burns.

Furthermore, in order to maximize the effect of Aloe vera in wound healing, researchers examined the formulate and optimize a herbal gel of Aloe vera extract containing Carbopol 934 as a gelling agent.

During the observation of differences in wound healing between the various treatments when compared to the control group. researchers found that tissue hyperplasia was lower in the control group compared to the other treated groups.

In animals group treated with gel, exerted an 80.14% healing up to 14(th) day compared to the untreated group I (control) animals of showed 52.68%.

Control group animals also showed inflammation and pus formation up to 5(th) day of study, compared to none in the treatment group.

These results supported the use of topical application of Carbopol 934 gel containing Aloe vera extract on the healing of skin wounds.

Taken altogether, herbal Aloe vera may be considered a functional topical remedy for the treatment of skin wound, pending to the confirmation of large sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The efficacy of aloe vera used for burn wound healing: a systematic review by Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)
(2) Aloe vera for treating acute and chronic wounds. by Dat AD, Poon F, Pham KB, Doust J.(PubMed)
(3) Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study, by Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O.(PubMed)
(4) Formulation development, optimization and evaluation of aloe vera gel for wound healing by Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J.(PubMed)
(5)

Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair  by Haichang Li,‡,1,2 Pu Duann,‡,1 Pei-Hui Lin,‡ Li Zhao,‡§ Zhaobo Fan,¶ Tao Tan,‡§ Xinyu Zhou,‡Mingzhai Sun,‡ Minghuan Fu,¶ Matthew Orange,‖ Matthew Sermersheim,‡ Hanley Ma,‡**Duofen He,‡‡ Steven M. Steinberg,‡ Robert Higgins,‡ Hua Zhu,‡ Elizabeth John,§Chunyu Zeng,‡‡ Jianjun Guan,¶ and Jianjie Ma. (PMC)