Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Tuesday, 19 February 2019

Phytochemical Allicin, the Anti Colon Cancer Bioactive compound

By Kyle J. Norton

Phytochemicals may be the next potential sources of a new medicine for the treatment of diseases with little or no side effects.

Phytochemical allicin may be the next natural ingredient for the prevention and treatment of colon cancer with no side effects, some scientists suggested.

Colon is a large intestine formed part of the digestive system where water is reabsorbed and waste material is stored as feces before being removed.

Colon cancer is the medical condition characterized by the cell growth irregularly and disorderly due to change of DNA.

Most cases of colon cancer start in the cell on the surface of the inner lining of the colon. However, at the later stage, colon cancer may cause secondary metastasis, leading to cancers forming on other tissues and organs, a distance away through lymph and blood.

According to the statistics, the risk of colon cancer has been rising in younger age groups coincidently with the declining rate in older age groups.

Sadly, the proportion of cases diagnosed in individuals younger than age 50 increased from 6% in 1990 to 11% in 2013. Most of these cases (72%) occur in people who are in their 40s.

The causes of colon cancer are unknown, Some researchers suggested that the widespread colon cancer over the past few decades in the developed world probably is the result of the promotion of the Western diet that leads to obesity.

Dr. E E Frezza, the lead scientist at the Texas Tech University Health Sciences Cente, in the study to examine obesity in the risk colon cancer wrote, "Obesity is a risk factor for many diseases" and "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".

And, "Although WC is better established as a measure of obesity than BMI, the evidence for colon cancer risk is not secure on this point; combining BMI and WC measurements would appear, at present, to be the wisest approach for colon cancer risk assessment".

The finding strongly suggested that obesity is a major risk factor of colon cancer.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find a natural ingredient for the treatment of colon cancer with no side effects, researchers at The Hebrew University of Jerusalem examined the effects of allicin on cell proliferation of colon cancer cell lines HCT-116, LS174T, HT-29, and Caco-2.

Injection of allicin preparation exerted a time- and dose-dependent cytotoxic effect on these cells at concentrations ranging from 6.2 to 310 μM.

Treatment with allicin induced HCT-116 apoptotic cell death through reducing the numbers of the chromosome in the DNA in the cancer cells, increasing the function and proteins associated with cell apoptosis and decreasing the expression of proteins involved cell proliferation and migration.

Futhermore, allicin treatment also induced cell death through cancer cell degradation.

Moreover, allicin application also activated the protein which protects the normal cell against oxidative damage triggered by injury and inflammation and reduces the function of the phytochemicals in the inhibition of the HCT-116 proliferation without affecting the cancer apoptosis.

In vivo and vitro, researchers evaluated the combined effect of allicin and CPT-11 against the human colon cancer cell line LoVo.

Allicin treatment alone inhibited the growth of LoVo cells in a dose and time-dependent manner, with an IC50 value of 32.23, 10.74, 6.58 mg x L(-1) at 24 h, 48 h, and 72 h, respectively.

The apoptosis rate of LoVo cells increased progressively as the cells were treated with increasing concentration of allicin in 24 h, while the apoptosis rate achieved peak value when the cells were treated with allicin at the concentration of 8 mg x L(-1) in 48 h.

These results strongly suggested that low concentrations of allicin (< 4 mg x L(-1)) leads to G2/M cell cycle arrest, and higer concentrations ( > 4 mg x L(-1)) exerts G1 + G2/M cell cycle arrest in 24 h.

Compared with a single use of CPT-11, the combined use of CPT-11 and allicin (4.0, 8.0 mg x L(-1), respectively) showed increasing cytotoxicity on the LoVo cells, with IC50 of 24 h decreasing from 47.5 to 7.4 and 7.2 mg x L(-1), respectively.

Dr. Gao Y, the lead scientist, wrote in the final report, "Allicin has significant anti-proliferation effect on human colon cancer cell line LoVo by induction of apoptosis and arrestment of the cell cycle and can enhance the cytotoxicity of CPT-11 on the colon cancer LoVo cell".

Taken altogether, phytochemical Allicin may be considered a bioactive compound for the prevention and combined with the primary medicine for the treatment of colon cancer, pending to large sample and multicenter human study.

Monday, 18 February 2019

Honey Improves the sleep Quality Naturally with No Side Effects, Scientists Say

By Kyle J. Norton

Scientists may have found a natural alternative for the improvement of sleep quality with no side effects, according to studies.

Sleep disorders are conditions can be acute or chronic. Most of us experience sleep disturbance sometimes due to some specific and unspecific events. However, chronic sleep disorders are the changes in the way that you sleep.

Most people with chronic sleep disorder experience symptoms of excessive daytime sleepiness, irregular breathing or increased movement during sleep, and difficulty falling asleep.

Sleep quality can be measured by examing the.way that you sleep, including the time period that you need to fall to sleep and how many times you have awakened and drifted back to sleep during night sleep.

According to the statistic provided by the National Sleep Foundation’s inaugural Sleep Health Index, 45 % of Americans have poor or insufficient sleep. that affects their daily activities at least once in the past seven days.

The National Sleep Foundation continued, "...despite sleeping within the recommended number of hours a night, 35 percent of Americans report their sleep quality as “poor” or “only fair.” Twenty percent of Americans reported that they did not wake up feeling refreshed on any of the past seven days".

What causes poor quality of sleep in American? Some researchers suggested these may be results from occupation and occupation stress.

Dr, Eui-Joong Kim, the lead scientists, in examing the stressors' effect on sleep quality said, "It is possible that different types of stressors may bring with them different impacts on sleep" and " (a) some aspect of daily stress (such as job stress) and life events (such as divorce, bereavement), (b) experimentally imposed stressors (laboratory-based studies), and (c) traumatic stressors (such as disasters or PTSD)".

Additionally, " The first and last categories typically involve a longer duration of the stress exposure with varying levels of intensity; the experimental stressors, on the other hand, typically involve a short-term exposure to mild stress".

These results partly explained why over 20% of American suffer from poor quality of sleep.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural compound for the improvement of sleep quality, researchers compared the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or Labiatae honey) to placebo (silan date extract) in children with upper respiratory tract infections (URIs).

The study included 300 children aged 1 to 5 years with URIs, nocturnal cough, and illness duration of ≤ 7 days from 6 general pediatric community clinics.

Eligible children received a single dose of 10 g of eucalyptus honey, citrus honey, Labiatae honey, or placebo administered 30 minutes before bedtime. There was a significant improvement in sleep quality from the night before treatment to the night of treatment in all 3 honey products and the placebo group.

However, the improvement was greater in the honey groups.

Honey products were rated higher than the silan date extract for symptomatic relief of their children's nocturnal cough and sleep difficulty due to URI, According to the survey returned from parents.

Dr. Cohen HA the lead scientist after taking into account co and confounders, said, "Honey may be a preferable treatment for a cough and sleep difficulty associated with childhood URI".

Furthermore, in order to reveal more information of honey effects in cough and sleep difficulty, researchers compared the effects of a single nocturnal dose of buckwheat honey or honey-flavored dextromethorphan (DM) with no treatment on nocturnal cough and sleep difficulty associated with childhood upper respiratory tract infections.

The study included 105 children aged 2 to 18 years with upper respiratory tract infections, nocturnal symptoms, and illness duration of 7 days or less were given a single dose of buckwheat honey, honey-flavored DM, or no treatment administered 30 minutes prior to bedtime.

Honey treatment group demonstrated significant differences in symptom improvement between treatment groups.

In paired comparisons, honey was significantly superior to no treatment for cough frequency and the combined score.

And, according to the survey returned by the parents, honey is most favorable for symptomatic relief of their child's nocturnal cough and sleep difficulty in children with upper respiratory tract infection.

Taken altogether, honey may be considered a functional remedy for the improvement of sleep quality, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study by Cohen HA1, Rozen J, Kristal H, Laks Y, Berkovitch M, Uziel Y, Kozer E, Pomeranz A, Efrat H. (PubMed)
(2) Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents by Paul IM1, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr. (PubMed)
(3) The Effect of Psychosocial Stress on Sleep: A Review of Polysomnographic Evidence by Eui-Joong Kim and Joel E. Dimsdale. (PMC)
(4) LACK OF SLEEP IS AFFECTING AMERICANS, FINDS THE NATIONAL SLEEP FOUNDATION

Honey, the Natural Treatment of Anxiety Disorder with No Side Effects, According to Studies

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of anxiety disorder, according to studies.

Anxiety disorder is a class of medical conditions associated with chronic worries and fear, leading to symptoms of the fast heart rate and shakiness.

Most people with anxiety may experience the feeling of nervousness in responding to events such as a problem at work, before taking a test, or before making an important decision.

According to the statistics, anxiety disorders are the most common mental illness in Canada and approximately 1 in every 8 Canadians is affected by the illness. In other words, over 250,000 people in Canada suffer from anxiety.

Family history, gender (women are more likely diagnosed with the condition compared to men), chronic stress, people with traumatic life experiences and the use of substances are some prevalent risk factors of anxiety.

However, some researchers suggested the widespread anxiety disorder probably is correlated with the onset of obesity over the past few decades. In fact, over 68% of American are either overweight or obese.

Dr. Lykouras L, the lead scientist in the concerns of obesity risk of anxiety disorder wrote, "
Obesity has been associated with anxiety disorders as follows: most of the studies show a positive relationship with panic disorder, mainly in women, with specific phobia and social phobia. Some authors have found a relationship with generalized anxiety disorder but a negative relationship has been also reported. Only a few studies have found the association between obesity and agoraphobia, panic attacks and posttraumatic stress disorder".

And, "Anxiety is also a common trait in personality disorders. There is no single personality type characteristic of the morbidly obese, they differ from the general population as their self-esteem and impulse control is lower. Obese patients present with passive-dependent and passive-aggressive personality traits, as well as a trend for somatization and problem denial".

The finding strongly suggested in some aspects anxiety can be a cause of obesity and vice versa.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural ingredient for the treatment of anxiety disorder with no side effects evaluated the antioxidant and anxiolytic-like effect of Tualang honey in stressed ovariectomized (OVX) rats.

The study included animals divided into 6 groups, (i) nonstressed sham-operated control rats, (ii) sham-operated control rats exposed to stress, (iii) nonstressed OVX rats, (iv) OVX rats exposed to stress, (v) OVX rats exposed to stress and treated with 17 β-oestradiol (E2) (20 μg daily, sc), and (vi) OVX rats exposed to stress and treated with Tualang honey (0.2 g/kg body weight, orally).

Before treatment of Tualang honey, OVX rats showed a significant increased anxiety-like behavior due to increased stress, compared to other groups. Injection of either Tualang honey or E2 significantly decreased anxiety-like behavior.

Honey treatment rats demonstrated reduced levels of malondialdehyde (MDA) and protein carbonyl (PCO) which are biomarkers of oxidative stress.

Furthermore, the levels/activities antioxidant enzymes produced by the rats such as superoxide dismutase (SOD), glutathione S-transferases (GST), glutathione peroxidase (GPx), and glutathione reductase (GR) were significantly increased in the brain homogenates of treated stressed OVX groups compared to untreated stressed OVX.

The finding strongly supported that honey processed the anxiolytic activity in the animal model.

Dr. Badriya Al-Rahbi, the lead scientist after taking into account co and confounders said, "Tualang honey has protective effects against brain oxidative stress and may be useful alternative anxiolytic agent especially for postmenopausal women.

Taken altogether, honey, particularly Tualang honey may be considered functional remedies for the prevention and treatment of anxiety disorder, pending to the confirmation of large samp;e size and multicenter human study.

Honey, the Best Remedy for the treatment of Asthma with No Side Effects

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of asthma, according to studies.

Asthma is a chronic inflammation of the airway of the lung with recurring symptoms. Asthma, attacks triggered by the stimuli can induce airway swollen and inflamed, leading to muscle constriction.

During the asthma attacks, patients may experience symptoms of difficult breathing, and severe wheezing in the breath and coughs that won't stop.

According to the statistic provided by the Centers for Disease Control and Prevention (CDC), 1 in 13 people in the US has asthma.

In other words, more than 26 million Americans have asthma, with half of the patients are children.

If you experience symptoms of a cough which often worse at night or early in the morning, wheezing in your breath, accompanied with chest tightness and shortness of breath, you may be at the early stage of asthma. Please check with your doctor to rule out the possibility.

Genetic and environmental factors are the most common risk factors associated with the onset of asthma. Some researchers suggested that the widespread obesity over the past few decades may also have a strong implication on the onset of the disease.

Dr. David A. Beuthe r, the lead scientist in the concern of the association of asthma and obesity said, "Cross-sectional and prospective cohort studies of humans have shown a modest overall increase in asthma incidence and prevalence in the obese, although body mass index does not appear to be a significant modifier of asthma severity".

And, "Studying the obesity-asthma relationship in large cohorts, in which self-reports are frequently used to ascertain the diagnosis of asthma, has been complicated by alterations in pulmonary physiology caused by obesity, which may lead to dyspnea or other respiratory symptoms but do not fulfill accepted physiologic criteria for asthma".

These results strongly suggested that if you are obese, your risk of asthma is increased substantially.

The study included 40 New Zealand white rabbits sensitized twice with a mixture of OVA and aluminum hydroxide on days 1 and 14.

Honey treatments were given from day 23 to day 25 at two different doses (25% (v/v) and 50% (v/v) of honey diluted in sterile phosphate buffer saline.

During the study, aerosolized honey treatment group restored the epithelium, mucosa, and submucosal regions of the airway infected by the application of OVA.

Futhermore, aerosolized honey treatment also found to reduce the number of airway inflammatory cells presented in bronchoalveolar lavage fluid and inhibit the goblet cell hyperplasia, an indication of airway remodeling in asthma.

The findings strongly suggested that aerosolized honey has a significant effect on the treatment and management of asthma in animal models.

Additional differentiation of the modulatory effect of honey, royal jelly, and propolis extract on peripheral blood leukocytes and lung inflammation in a mouse conalbumin-induced asthma model in mice model divided into

* The mice in group I that were not sensitized or treated; they were kept as controls.

* The mice in group II that were sensitized and challenged with conalbumin. Twenty-four hours after the first challenge with antigen.

* The mice in group III received 0.5 mg/kg of dexamethasone intraperitoneally per day for 18 consecutive days and kept as positive controls.

* The mice in groups IV, V, and VI received 650, 1000, and 30 mg/kg of honey, royal jelly, and propolis (aqueous and ethanolic extract), respectively, once per day for 18 consecutive days.

At the end of the experiment, by comparing the blood sample before and after treatment, researchers showed
* The groups treated with propolis extract exhibited considerable ameliorative effects against asthma, probably due to the expression of flavonoids and phenolics that exert antioxidative effects.

* Honey- or royal jelly-treated groups exhibited an increased incidence of asthma cascade events due to increased inflammatory cells, probably due to the antagonist to bronchial asthma cases.

The results clearly indicated that not all honey is the same. Some can be used for asthma while others can not, probably due to types of chemicals compounds found in the pollen

Taken altogether, honey and other bee products may be considered functional remedies for the prevention and treatment of asthma, pending to the confirmation of the types of honey in a large and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma by Kamaruzaman NA, Sulaiman SA, Kaur G, Yahaya B1.(PubMed)
(2) Evaluation of propolis, honey, and royal jelly in amelioration of peripheral blood leukocytes and lung inflammation in mouse conalbumin-induced asthma model by El-Aidy WK1, Ebeid AA1, Sallam Ael-R1, Muhammad IE2, Abbas AT3, Kamal MA4, Sohrab SS. (PubMed)
(3) Obesity and Asthma by David A. Beuther, Scott T. Weiss, and E. Rand Sutherland. (PMC)

Honey, the Best for the Treatment of Ocular Demodex and Dry-Eye with No Side Effects

By Kyle J. Norton

Scientists may have found a natural alternative for the treatment of Ocular Demodex and Dry-Eye, according to studies.

Believe or not, the Demodex in eyelashes that cause the severity of ocular discomfort is quite common in the US. According to the US Federal Science, over 70% of American suffer from the presence of Demodex without even noticing.

The increase in age, patients with conjunctival papillary hypertrophy, are some most common Demodex risk factors.

Furthermore, methicillin-resistant Staphylococcus aureus (MRSA) was detected more often on eyelids with Demodex.

The finding strongly suggested that Demodex plays a pathogenic role in the ocular discomfort linked with aging.

Dry eye happened mostly in the older adults is a condition in which a person doesn't have enough quality tears to clean and nourish the eye, leading to a chronic vision problem.

Dry eye in most cases is caused by the inadequate amount of tears due to lower than normal amount of tear production or tears evaporate too quickly from the eyes and poor quality of tears.

People with dry eye may experience symptoms of irritation, gritty, scratchy or burning eyes; a feeling of something in their eyes; excess watering; and blurred vision.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers with an aim to find a natural source for the treatment of vision problem compared the Manuka honey and tea tree oil against ocular Demodex.

The study included 53 viable Demodex mites acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Then, the viable mites were randomized to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment.

Compared to the results of four treatments, researchers found that the survival probabilities are lowest with 100% tea tree oil, and highest with cyclodextrin-complexed and uncomplexed Manuka Honey.

The finding clearly suggested that the efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex.

In order to reveal more information about honey anti-dry eye effects, researchers evaluated
the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia).

The study included 24 participants aged 20 to 55 years with contact lens-related dry eye randomized to two treatment groups with 20 completed the study.

One group was received Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks while the other group completed the treatments in the reverse order.

The Optimel treatment exerted an improvement of Dry eye symptoms significantly and patients with more severe symptoms at baseline showed a greater improvement in symptoms.

Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.

However, due to the short duration of treatment, there were no significant differences observed in the objective signs of a dry eye.

Researchers at the ean of the experiment wrote in the final report, "Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use".

Taken altogether, honey, particularly Tualang honey may be considered functional remedies for the prevention and treatment of ocular Demodex and dry-eye, pending to the confirmation of larger sample size and multicenter human study.

Whole Food Avocado, the Natural Sources of Antioxidants Against Lipids, Proteins and Cells DNA Damage

By Kyle J. Norton

In the search of natural therapy for the prevention and treatment of diseases involved oxidative stress, scientists may have found a dietary whole fruit with the efficacy compared to that of conventional medicine, according to studies.

Antioxidants are stable atoms which inhibit free radical and stop the free radicals chain reaction.

Free radicals on other hand are unstable and highly reactive molecules with a single or unpaired electron on the outer ring. In order to maintain the balance, free radicals are ready either to donate or intercept an electron from another stable atom, leading to domino's effect which can not be stopped until the electron is paired or inhibited by an antioxidant.

Overexpression of free radicals and suppressed levels of antioxidants cause oxidative stress, leading to the damage cell structure, protein and lipid and alternation of cell DNA.

Every day, the human body is bombarded by the invasion of free radicals. Some foods we eat, the polluted air we breathe, the use of the toxic chemical substances and the body metabolism all contribute to the expression of free radicals in our body.

Luckily, for a healthy individual, our body antioxidant enzymes are good enough to maintain the balance ratio, regardless of the levels of free radicals produced.

However, for the people with suppressed antioxidant enzymes in the body, dietary sources of antioxidants from fruits and vegetable can be very helpful.

Researchers at the Karolinska Institutet suggested that a high intake of fruit and vegetables is related to low oxidative stress.

Dr. Rikard Åsgård, the lead scientist said, "Fruit and vegetable intake was inversely related to oxidative stress" and " An increased intake of fruit and vegetables can, therefore, be beneficial for patients with type 2 diabetes since these patients are documented to have raised oxidative stress and inflammation".

The results clearly encouraged that people who suppress antioxidant produced by the body should add some portions of fruits and vegetables into their diet.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B.

With an aim to find natural ingredients with significant antioxidant effects against bacterial infection in the induction of oxidative stress, researchers examine the thyl acetate, containing 70% acetone, and 70% methanol extracts of the peel, pulp, and seed from two avocadi (Persea Americana Mill) against Gram-positive bacteria.

Peels and seeds were found to possess higher amounts of phenolics and had a more intense in vitro antioxidant potential, compared to the pulp.

The efficacy of the peels and seeds against Gram-positive bacteria were associated with the rich in catechins, procyanidins, and hydroxycinnamic acids, whereas the pulp was particularly rich in hydroxybenzoic and hydroxycinnamic acids and procyanidins.

The results indicated that avocado displays moderate antimicrobial effects against Gram-positive bacteria.

Furthermore, injection of the extracts (70% acetone) from avocado peels and seeds as inhibitors of oxidative reactions in meat patties, researchers also found that avocado extracts protected meat lipids and proteins against oxidation with the effect on lipids being dependent on the avocado variety.

Moreover, in the examine the antioxidant activity of other compounds such as monounsaturated fatty acids, tocopherols, carotenes, acetogenins and sterols found in avocado researchers once again confirmed the antioxidant property by comparing the lipophilic AOC of the pulp and the fruit hydrophilic AOC.

According to the chemical assay of oxygen radical absorbance capacity (ORAC), the highest antioxidant activity of lipophilic AOC was attributed to the presence of high levels of acetogenins, compared to other compounds.

The findings showed that the presence of emulsifying agents which are soluble in both fat and water could serve as novel lipophilic antioxidants in a food matrix.

Interestingly, the University of California in the study "the effect of harvest date on nutritional compounds and antioxidant activity (AOC) in avocado (Persea Americana Mill. cv Hass) fruit" , suggested that AOC in early harvested fruit after storage for 35 days was much higher antioxidant contents than that in late-harvested fruit after storage for 21 days.

Taken altogether, there is no doubt that whole fruit avocado processed a strong antioxidant property may be considered a functional food for the prevention and treatment of oxidative stress-related diseases

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties by Rodríguez-Carpena JG1, Morcuende D, Andrade MJ, Kylli P, Estévez M.(PubMed)
(2) Activity-guided identification of acetogenins as novel lipophilic antioxidants present in avocado pulp (Persea americana) by Rodríguez-Sánchez D1, Silva-Platas C, Rojo RP, García N, Cisneros-Zevallos L, García-Rivas G, Hernández-Brenes C.(PubMed)
(3) Effect of harvest date on the nutritional quality and antioxidant capacity in 'Hass' avocado during storage by Wang M1, Zheng Y, Khuong T, Lovatt CJ.(PubMed)
(4) High intake of fruit and vegetables is related to low oxidative stress and inflammation in a group of patients with type 2 diabetes by Rikard Åsgård,1 Elisabet Rytter,2 Samar Basu,2 Lilianne Abramsson-Zetterberg,3Lennart Möller,1 and Bengt Vessby. (PMC)

Celery, The Potential Anti High Blood Cholesterol with No side Effects

By Kyle J. Norton

Scientists may have found a whole vegetable for the prevention and treatment of high blood cholesterol comparable to that of conventional medicine without inducing any side effects, according to studies.

High blood cholesterol is a medical condition of abnormally high levels of cholesterol in the blood.

There are 2 types of cholesterols in the human body, the low-density lipoproteins, and high-density lipoproteins.

The low-density cholesterol plays an important role in building cell membranes, inducing the production of bile, steroid hormones and vitamin. However, long-term accumulation of cholesterol in the bloodstream not only impedes the blood flow of the arteries but also increases the risk of plaque built up on the arterial walls.

The high-density lipoprotein removes cholesterol from the blood and returns them to the liver. However, if the low-density lipoprotein in the bloodstream was found in high amounts, compared to high-density lipoprotein, then some bad cholesterols may be left in the arteries, causing the onset of high blood cholesterol.

The healthy ratio of blood cholesterol is lower than 4 (levels of low-density lipoprotein)/ 1(levels of high-density cholesterol).

What causes high blood cholesterol? Epidemiological studies suggested that a poor diet with rich in saturated and trans fat, red meat and processed foods and few in fruits and vegetables are the most common risk factors that cause the onset of high blood cholesterol in the Western world.

According to the statistic, in Australia, over 1 million of the population have high blood cholesterol. The highest prevalent group is those between 55 to 64 year age group.

Sadly, one in five Australians aged 18 to 34 also has high total cholesterol.

Dr. Henry N. Ginsberg, the lead scientist in the cardiovascular disease team in examining the risk of high blood cholesterol and diet cholesterol in young and healthy men said, "Fasting plasma total cholesterol concentrations increased by 1.47 mg/dL (0.038 mmol/L) for every 100 mg dietary cholesterol added to the diet (P <.001). Low-density lipoprotein (LDL) cholesterol increased in parallel." and " increases in dietary cholesterol resulted in linear increases in fasting total and LDL cholesterol in young, healthy men".

These results suggested that short-term intake of high cholesterol diet does not have an effect on postprandial plasma lipids or an increased atherogenic potential of postprandial serum. In other words, high blood cholesterol is a condition caused by long-term high cholesterol diet that takes years to develop.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

With an aim to find a natural ingredient or whole food which processes anti-high blood cholesterol activity with no side effects, researchers at the National University of Singapore looked into the antihyperlipidemic property of aqueous celery extract.

The study included 2 groups of Wistar rats fed a high-fat diet for eight weeks to induce hyperlipidemia. One group was supplemented with aqueous celery extract in the diet while the other group served as control.

At the end of the experiment, treatment group exerted a significant reduction in the serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) concentrations, compared to control.

The concentration of hepatic TG was significantly higher in the celery-treated group than in the control group. However, the hepatic triacylglycerol lipase (HL) activity was found to be significantly lower in the celery-treated rats observed for the hepatic microsomal P450 content which is an indication of individual hepatic clearance.

Surprisingly, researchers discovered that aqueous extract of celery does not contain 3-n-butylphthalide (BuPh), a unique compound in celery. This result suggested that the efficacy of celery probably is associated with other major unknown compound compounds.

Futhermore, in the examining other compounds processed the anti-high blood cholesterol activity, researchers explored the antihyperlipidemic effect of ethanolic extract of seeds of Apium graveolens L. (celery) and its chloroform and aqueous basic fraction in olive oil induced hyperlipidemic rats.

The antihyperlipidemic activity of Apium graveolens has been found in the previous study was effective as of those of standard drug Atorvastatin (50mg/kg).

The study included the ethanolic extract and its fractions administered orally at doses of 200 and 400 mg/kg body weight in rats following by the Olive oil (5ml/kg oral dose) administered 30 min after treatment.

The ethanolic extract and its fractions of celery at a dose-dependently inhibited the total cholesterol (TC) triglycerides (TG), low-density lipoproteins (LDL) level, and significantly increased high density lipoprotein (HDL) level.

The inhibition of high blood cholesterol was attributed to the major compounds terpenoid, tannin, alkaloid, glycoside, flavonoid, and sterols.

Taken altogether, celery containing high amounts of bioactive compounds may be considered a functional food for the prevention and treatment of high blood cholesterol with no side effects

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet by Tsi D1, Das NP, Tan BK.(PubMed)
(2) Effect of chloroform and an aqueous basic fraction of ethanolic extract from Apium graveolens L. in experimentally-induced hyperlipidemia in ratsm by Iyer D1, Patil UK(PubMed)
(3) Hypolipidemic and antioxidant activity of mountain celery (Cryptotaenia japonica Hassk) seed essential oils by Cheng MC1, Lin LY, Yu TH, Peng RY.(PubMed)
(4) The mechanism underlying the hypocholesterolaemic activity of aqueous celery extract, its butanol and aqueous fractions in genetically hypercholesterolaemic RICO rats by Tsi D1, Tan BK.(PubMed)
(5) Effects of celery extract and 3-N-butylphthalide on lipid levels in genetically hypercholesterolaemic (RICO) rats by Tsi D1, Tan BK.(PubMed)
(6) A Dose-Response Study of the Effects of Dietary Cholesterol on Fasting and Postprandial Lipid and Lipoprotein Metabolism in Healthy Young Men by Henry N. Ginsberg, Wahida Karmally, Maliha Siddiqui, Steve Holleran, Alan R. Tall, Steven C. Rumsey, Richard J. Deckelbaum, William S. Blaner, and Rajasekhar Ramakrishnan. (PMC)