Phytochemical Indole-3-carbinol, the Anti Pancreatic Cancer Cells Plant-Based Bioactive Compound

By Kyle J. Norton

Scientists may have found a bioactive compound for the prevention and treatment of pancreatic cancer, according to studies.

Cancer of pancreas or pancreatic cancer is a condition of a malignant neoplasm of the pancreas.

Most cases of primary pancreatic cancer start in the cells on the surface of the inner lining of the pancreas as a result of irregular cell growth caused by the alternation of DNA.

The pancreatic cancers start in the ducts (an exocrine component of the pancreas) carried pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.

According to the statistic, pancreatic cancer is the fourth leading cause of cancer death in both men and women in the US. The cancer has the poorest prognosis compared to other major types of cancer, with a 5-yr survival rate of approximately 5%.

More precisely,  in the US, the age-adjusted incidence of pancreatic cancer is higher in men compared to women regardless of ethnicity.

Epidemiologically, the increase in age, gender, ethnicity, smoking, being obese and obese and certain medical conditions such as diabetes, family history are associated with an increased risk of pancreatic cancer.

Some researchers suggested that genetic preposition also place the carrier in a greater risk for the onset of the disease.

Dr. Alison P. Klein, in the joint study led by the Johns Hopkins University School of Medicine, Baltimore, Maryland suggested people who carry the mutated gene BRCA2 or PALB2 and genetic variation at the ABO blood group locus are associated with a modest increase risk of pancreatic cancer.
Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

On the finding the natural ingredient for the treatment of pancreatic cancer without inducing chemoresistance due to the overexpression of microRNA-21 (miR-21), researchers at the Seoul National University College of Medicine evaluated the efficacy of indole-3-carbinol (I3C) in suppressing miR-21 expression.

Where miR-21 simultaneously regulates multiple programs that enhance cell proliferation, apoptosis, and tumor invasiveness by targeting the genes associated with cancer proliferation.

In human pancreatic cancer cells (Panc-1), injection of 13C inhibited the expression of miR-21 positively-correlated in a time- and dose-dependent manner.

13C and gemcitabine combination therapy increased cytotoxicity in Panc-1 cells.

The efficacy of 13C was attributed to its activity in promoting cancer cell apoptosis by attenuating miR-21 transfection.

The finding suggested that I3C would be effective for enhancing the sensitivity of pancreatic cancer cells to gemcitabine via the inhibition of the overexpression of miR-21.

Additional experiment in demonstrating the ability of a dietary agent, indole-3-carbinol (I3C), to lower the LD(50) of gemcitabine (Gemzar) in decreasing growth of both male (MiaPaca2) and female (SU86.86) pancreatic cancer cells, researchers found that

* Without an injection of 13C, female pancreatic cancer cells were more resistant to gemcitabine.

* In male MiaPaca2 cells application of 1, 10 or 100 μM of I3C induced apoptosis by reactivating the tumor suppressor gene in pancreatic cancer cells. 

* 13C also protects the healthy pancreas cells by enhancing the activity of tumor suppressor gene.

Moreover, by examing the DNA methylation researchers suggested suppressor tumor gene (p16INK4a) inactivation in the promotion of hypermethylation is considered an early event in pancreatic carcinogenesis.

DNA methylation is a process by which methyl groups are added to the DNA molecule.

These results clearly indicated, I3C, a possible non-toxic hypomethylating agent, combined with the anticancer agent, gemcitabine, to be a powerful strategy for treating pancreatic cancer.

Taken altogether, bioactive compound indole-3-carbinol (I3C) may be used for the prevention and treatment of pancreas cancer, pending to the results of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol by Paik WH1, Kim HR, Park JK, Song BJ, Lee SH, Hwang JH.(PubMed)
(2) Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol. by Lyn-Cook BD1, Mohammed SI, Davis C, Word B, Haefele A, Wang H, Hammons G.(PubMed)
(3) Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreaticcell lines: the role of human equilibrative nucleoside transporter 1 by Wang H1, Word BR, Lyn-Cook BD.(PubMed)
(4) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)

Ginger, The Best for the Treatment of Diabetes and Diabetes Complications With No Side Effect

By Kyle J Norton

Ginger may have a potential and profound effect in regulating the abnormally high blood sugar, some scientists suggested.

Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.

According to the statistic, approximately, 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes. And, hyperglycemia is a hallmark sign of diabetes(both type 1 diabetes and type 2 diabetes) and prediabetes.

Some researchers suggested that people who are living under prolonged periods of stress due to chronic illness or stress are associated with a higher risk of high blood sugar.

Other suggested that an unhealthy diet such as high in saturated and trans fat, red meat, and processed food and lack of physical exercise have many folds increased the risk for the onset of hyperglycemia.

In fact, shift workers accompanied by an unhealthy lifestyle are the joint association with the risk of type 2 diabetes.

Dr. Shan Z, in the concerns of the rotating night shift work and lifestyle factors in the risk of diabetes using the data of Nurses' Health Study (1988-2012) and Nurses' Health Study II (1991-2013) and comparing to the 143 410 women without type 2 diabetes, cardiovascular disease, or cancer at baseline, said, " The multivariable-adjusted hazard ratios for type 2 diabetes were 1.31 (95% confidence interval 1.19 to 1.44) per five year increment of duration of rotating night shift work and 2.30 per unhealthy lifestyle factor (ever smoking, low diet quality, low physical activity, and overweight or obesity)".

"For the joint association of per five-year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes, the hazard ratio was 2.83 (2.15 to 3.73) with a significant additive interaction (P for interaction <0.001)".

How severe of the diabetes risk in nurses in the rotating shift accompanied by an unhealthy diet. According to the team, during 22-24 years of follow-up, 10 915 cases of incident type 2 diabetes occurred.

The risk of type 2 diabetes is even higher if each individual factors are also included.

These results clearly suggested, the onset of diabetes is not caused by a single factor but associated with a group set of risk factors.

Luckily, most people with some of above risk factors do not develop hyperglycemia or type 2 diabetes.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient and whole food for the treatment of diabetes and diabetes complications, researchers examine the action of ginger in the diabetic population.

Selected mice fed by either high fat diet or standard diet for a period of 17weeks were given phloretin isolated from apple and [6]-gingerol isolated from ginger supplemented at two different doses.

Application of phloretin and [6]-gingerol inhibited the formation of AGEs by suppressing the receptor for advanced glycation end products (RAGE).

Where Advanced glycation end products are proteins or lipids that become glycated as a result of exposure to sugars. The products can substantially worsen certain chronic diseases such as diabetes.

Phloretin or [6]-gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs, and insulin levels and enhanced GSH/GSSG ratio.

These results suggested that phloretin or [6]-gingerol supplementation not only inhibited the oxidative stress that causes abnormally high blood glucose but also improved the insulin resistance against the onset of diabetes complications in mice fed with high-fat diet.

Futhermore, the assessment of the effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus with the consumption of 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks, also found that ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with placebo group (p < 0.05).

Ginger improved fasting glucose and parameters associated with the onset of insulin resistance without inducing any side effects.

Dr. Arablou T after taking into account co and confounders said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered an effective treatment for the prevention of diabetes complications".

Taken altogether, ginger may be considered a functional food for the prevention and treatment of diabetes and diabetes complication induced by abnormally high blood glucose.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M. (PubMed)
(2) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(3) Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats by Tzeng TF1, Liou SS2, Tzeng YC3, Liu IM. (PubMed).
(4) Rotating night shift work and adherence to an unhealthy lifestyle in predicting the risk of type 2 diabetes: results from two large US cohorts of female nurses by Shan Z1,2, Li Y2, Zong G2, Guo Y3,4, Li J2,3, Manson JE3,5, Hu FB2,3,6, Willett WC2,3,6, Schernhammer ES3,6,7, Bhupathiraju SN2, (PubMed)

Phytochemical Allicin, Gobbles Up Endometrial Cancer Cells in Vitro

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of endometrial cancer with no side effects, according to studies.

The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particularly to the menstrual cycle.

Endometrial cancer is a late adulthood cancer characterized by the cell growth irregularly and uncontrollably in the endometrial tissue.

The cause of endometrial cancer is an alternation of call DNA in the endometrium.

Most cases of endometrial cancer start in the cells on the surface of the inner lining of the endometrium. After penetrating deeper into the organ tissue, the cancerous cell may induce secondary metastasis through lymph and blood.

Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer. The average age diagnosed with endometrial cancer is 60.

According to the statistic provided by the American Cancer Society, every year, approximately,
63,000 new cases of cancer of the body of the uterus (uterine body or corpus) will be diagnosed.
Endometrial cancer causes the death of 11,350 women,, every year.

The 5-year survival rate for women with uterine cancer is 81%. However, the 5 years mortality rate in black women is substantially higher, compared to white women.

Most common risk factors of endometrial cancer are associated with hormone change due to menopause, use of birth control pills, and tamoxifen pregnancy,  ovarian tumors, and polycystic ovarian syndrome.

Some researchers suggested that obesity is one major cause of hormone change associated with the onset of endometrial cancer.

Dt. Evan L. Busch, the lead scientists analyzed the endometrial cancer risk factors, said, " Compared with not being obese, obesity increased the odds of having an ER-positive tumor at cut points of 0% to 20% [maximum OR, 2.92; 95% confidence interval (CI), 1.34–6.33] as well as the odds of having a PR-positive tumor at cut points of 70% to 90% (maximum OR, 2.53; 95% CI, 1.36–4.68)".


And, " Obesity may be associated with greater endometrial tumor expression of ER and PR. Adding either marker does not appear to improve mortality prediction beyond the standard predictors".

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find the ingredient for the treatment of endometrial cancer, researchers determined whether pure allicin exhibits the antiproliferative effect reported for garlic in vitro models.

Treatment of allicin, but not its precursor alliin, inhibited proliferation of human endometrial (Ishikawa) cancer cells (50% inhibitory concentration = 10-25 microM).

Furthermore, the pure allicin and water extract of garlic powder with equivalent allicin concentrations displayed a similar potency.

The result strongly suggested that allicin is responsible for the antiproliferative effect of the extract.

Allicin treatments inhibited the levels of antioxidants produced by the cancer cell line and the extent of the decrease in glutathione (GSH) levels correlated well (r = 0.75) with the growth inhibitory activity of allicin.

However, the magnitude and kinetics of which significantly varied depending on cancer cell type.

Dr. Hirsch K, the lead scientist said, allicin plays a major role in the antiproliferative effect of water-soluble garlic preparations and that this effect may be attributed to the ability of allicin to transiently deplete the intracellular GSH level.

Moreover, treatment of allicin also induces cancer cell death through activating proteins associated with cell apoptosis and cell death programming.

Also, the efficacy of allicin also was attributed to the function of bioactive compound stimulating the protein involved "on" or "off" switch of cell apoptosis, as well as inhibiting the antioxidant enzymes produced by the cancer cells.

Taken altogether, phytochemical allicin may be considered a bioactive compound for reducing risk and combined with the primary medicine for the treatment of endometrial cancer.

However, intake of allicin in form of supplement should be taken with extreme care as acute toxicity was reported in a number of cases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. (PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH. (PubMed)
(3) Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction by Evan L. Busch, Marta Crous-Bou, Jennifer Prescott, Maxine M. Chen, Michael J. Downing, Bernard A. Rosner, George L. Mutter and Immaculata De Vivo. (AACR)

Bilberry Protects Your Vision Against Eye Strain (Asthenopia), According to Studies

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a whole fruit for the prevention and treatment of asthenopia (eye strain), according to studies.

Asthenopia is a condition characterized by nonspecific symptoms such as fatigue, pain in or around the eyes, blurred vision, headache, and occasional double vision.

Symptoms occur mostly in the people who have spent a long time in the visual task focusing, such as prolonged reading on the screen or newspaper.

Some researchers suggested by giving the eye some rest such as looking on a distant object at least once an hour can be helpful in alleviating the problem.

Mechanically, eye muscle imbalance or uncorrected vision can also cause asthenopia. 

Symptoms of asthenopia include sore or irritated eyes dry or watery eyes,  blurred or double vision and increased sensitivity to light.

Some people may also experience symptoms of trouble focusing and pain in the neck, shoulder, and neck.

If you experience some of the above symptoms, you may have asthenopia, please make sure you check with your doctor for preventive measure.

Some researchers suggested that asthenopia may also be a symptom in people with a chronic headache.

Dr. Vincent AJ, the lead scientist in the investigation of a chronic headache asthenopia wrote, "Sensitivity to light in the absence of a headache was reported by 27.8% of controls and 44.7% of headache sufferers (p less than 0.05)" and "The latter figure increased to 71.3% when a headache was actually present (p less than 0.001)".

These results indicated a strong correlation between a chronic headache and asthenopia.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.


The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers with an aim of finding a natural ingredient for the treatment of asthenopia examined the effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans.

A double-blind, randomized, parallel-group and the placebo-controlled trial was conducted by the Human Life Science R&D Center,
* In the Active group, eleven subjects were given a supplement containing omega-3 fatty acid-rich fish oil (docosahexaenoic acid 783 mg/day, eicosapentaenoic acid 162 mg/day), bilberry extract (anthocyanidin 59 mg/day), and lutein (17.5 mg/day) in soft gel capsule form, every day for 4 weeks.

* In the Placebo group, nine subjects were received placebo capsules.

According to the questionnaires taking before and after the experiment, researchers found that
* Asthenopia symptoms such as "stiff shoulder, low back pain", "frustration", "dry-eye", and "stuffy head" were improved in the Active group compared to the placebo.

* Subjected received the supplement also demonstrated a significant improvement od mental symptoms such as fatigue after 4 weeks.

No side effects were reported in the active group at the 2 and 4 weeks of supplemental injection, according to the return questionnaires.

The results strongly supported the use of dietary supplementation with the combination of omega-3 fatty acid-rich fish oil, bilberry extract, and lutein for the treatment of asthenopia.

Taken altogether, bilberry used alone or combined with other supplements may be considered functional remedies for the prevention and treatment of asthenopia with no side effects, pending to the validation of larger sample size and multicenter human study.

Taken altogether, bilberry processed abundantly bioactive compounds may be considered a natural remedy for the treatment of dry eye with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans by Kawabata F1, Tsuji T. (PubMed)
(2) A controlled study of visual symptoms and eye strain factors in chronic headache by Vincent AJ, Spierings EL, Messinger HB. (PubMed)

Artichoke May Cure Non Alcoholic Liver Disease (NAFLD), Human Studies Suggest

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a herbal remedy for the prevention and treatment of nonalcoholic liver disease (NAFLD), according to studies.

Nonalcoholic liver disease is a chronic condition caused by fat accumulated over time in the liver, affecting people who drink little to no alcohol.

In other words, if you have fat that makes up over 5% of the liver, you are considered to have fatty liver disease.

Nonalcoholic liver disease can be classified into noninflammatory fatty liver and inflammatory liver steatohepatitis.

Most patients with nonalcoholic fatty liver disease are asymptomatic. However,  in the later stage, patients may experience symptoms of enlarged liver, persistent fatigue and pain in the upper right abdomen, depending on the formation of scars.

According to the statistics provided by the Canadian Liver Foundation, more than 50% of Canadians are overweight and 75% of obese individuals are at risk of developing a simple fatty liver, including 23% of them will develop fatty liver with inflammation sometimes during their lifetime.

According to the epidemiological studies, patients with nonalcoholic liver disease have elevated levels of liver enzymes gamma-glutamyl transferase (GGT), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) which are the markers used to predict the severity of liver disease including fatty liver.

A blood test is required if your doctor suspects you might develop fatty liver disease, including NAFLD.

Other tests for diagnosis of liver fatty disease may include ultrasound, computed tomography (CT), proton magnetic resonance spectroscopy (H-MRS), and magnetic resonance imaging (MRI).

The exact causes of nonalcoholic fatty liver disease are not identified. However, some researchers suggested unhealthy diet-induced obesity may be a major cause of the widespread NAFLD in the Western world.

Dr. Al-Dayyat HM, the lead scientist in the examination of the non-alcoholic fatty liver disease and associated dietary and lifestyle risk factors, said, "Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide with a reported prevalence ranging 20-30% depending on the studied populations".

And, "The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity, unhealthy dietary pattern, and sedentary lifestyle. NAFLD patients are at increased risk of cardiovascular and liver-related mortality".

The findings strongly suggested if you are obese, you are at a substantially higher risk of fatty liver disease, compared to healthy weight individuals.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

In the course od finding a herbal remedy for the treatment of nonalcoholic liver disease (NAFLD), researchers evaluated the potential to attenuate lipid disturbances of Jerusalem artichoke (JA).

Selected Wistar rats included in the study were fed a control diet, a 60 % fructose-enriched diet (FRU), or an FRU with 10 % JA (n 6-7) for 4 weeks.

According to liver samples collected for biochemical and global gene expression analysis, pretreatment of dietary JA supplementation showed strong activity against hepatic TAG accumulation induced by the FRU.

Futhermore, JA also demonstrated significant inhibition of inflammation-inducing the expression of proteins associated with liver fatty acid synthesis, and development of liver fibrosis.

The results suggested that JA processes beneficial effects in the prevention of non-alcoholic fatty liver disease in molecular levels.

In order to collect more information about artichoke anti-non-alcoholic fatty liver disease, scientists investigated the artichoke leaf extract (ALE) potential hepatoprotective activity in patients with NAFLD.

100 subjects with ultrasound-diagnosed NAFLD randomized to either ALE 600 mg daily or placebo for a 2-month period were included in the randomized double-blind placebo-controlled parallel-group trial. 

According to the results from 90 patients completed the study (49 ALE and 41 placeboes), intake of ALE did not exert any side effects.

ALE at the end of experiment displays a liver protective effect by increasing the hepatic vein flow reducing portal vein diameter (p < .001) and liver size (p < .001).

Injection of ALE also inhibited the liver damage and oxidative stress markers.

Moreover, the artichoke leaf extract also is found to reduce the levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations, according to the assays.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of non-alcoholic liver disease, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References

(1) Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats by Chang WC1, Jia H2, Aw W2, Saito K2, Hasegawa S3, Kato H. (PubMed)
(2) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial by Panahi Y1, Kianpour P2, Mohtashami R3, Atkin SL4, Butler AE5, Jafari R6, Badeli R7, Sahebkar A. (PubMed)

Honey Detoxes the Liver Against Toxicity in Vivo, According to Scientists

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy which detoxes the liver toxicity, according to studies.

The liver is a large organ in the human body that processes a number of function, including producing bile to aid digestion, detoxifying metabolites, synthesizing proteins, and filtering blood from the digestive tract before passing them to other parts of the body.

Symptoms of liver toxicity include gastrointestinal discomforts such as nausea, vomiting, and jaundice. Some patients with liver toxicity also experience the symptom of right upper quadrant abdominal pain.

If you have some of the aforementioned symptoms, please check with your doctor immediately. Acute liver toxicity may be life-threatening.

Most common causes of liver toxicity in the Western world are excessive alcohol drinking and long term use of certain medications and overdoses of herbal supplements.

Dr. Victor Navarro, M.D. in the examination of the herbal and dietary supplement in risk liver toxicity wrote, "Herbal and dietary supplements (HDS) -induced liver injury now accounts for 20% of cases of hepatotoxicity in the United States based on research data".

And, "The major implicated agents include anabolic steroids, green tea extract, and multi-ingredient nutritional supplements (MINS)".

The results strongly suggested if you are currently using some of the herbal and dietary supplements, please make sure that you follow the direction and guideline set out in the products to prevent unnecessary live toxicity.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding the natural and potential ingredient for the prevention of liver toxicity, researchers investigated the honey protective effect against toxic materials.

The study included 24 male rabbits allocated into four groups six rabbits each given daily during 24 days of experimentation; group 1: control group, received distilled water (0.1 ml / kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily).

Injection of lead group induced hepatic injury and caused anemia during three weeks of the exposure.

Treatment with honey in the lead group not only prevented liver lead toxicity and but also ameliorated lead-induced anemia.

The results clearly suggested that honey has a protective effect against lead-induced blood, hepatic and toxic effects.

Furthermore, in order to reveal more information about honey liver protective activity, researchers examined the Manuka and Talh honey against cisplatin (CISP)-induced hepatotoxicity in a rat model.

Before injection of Manuka and Talh honey, rats treated with CISP induced liver dysfunction observed by liver toxicity.

Administration of Manuka honey prevented CISP-induced histopathological changes observed in the rat liver but not in the kidney.

Manuka and Talh honey also reduced the oxidative stress in the liver by stimulating the production of antioxidant enzymes from the treated rats.

In other words, both honey inhibited the expression of proinflammatory cytokines including COX-2 and NF-κB by the cisplatin (CISP)-induced hepatotoxicity.

Taken altogether, honey, particularly Manuka and Talh honey may be considered function remedies for the prevention and treatment of liver toxicity, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway by Neamatallah T 1, El-Shitany NA , Abbas AT , Ali SS , Eid BG. (PubMed)
(2) Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity by Fihri AF1, Al-Waili NS, El-Haskoury R, Bakour M, Amarti A, Ansari MJ, Lyoussi B. (PubMed)
(3) Liver Injury from Herbal and Dietary Supplements by Victor Navarro, M.D.,1 Ikhlas Khan, Ph.D.,2 Einar Björnsson, M.D., Ph.D.,3 Leonard B. Seeff, M.D.,1 Jose Serrano, M.D., Ph.D.,4 and Jay H. Hoofnagle, M.D.(PMC)

Phytochemical Isothiocyanates as Antioxidants

By Kyle J. Norton 

Scientists may have found a bioactive compound Dithiolthiones isolated from the cruciferous vegetables for the prevention and treatment of oxidative stress-related diseases, according to the studies.

According to the oxidative stress theory, aging and cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancers are most common conditions associated with oxidative stress.

Antioxidants are stable molecules which play a critic role to protect our body against oxidation.

There are 2 types of antioxidants, antioxidants produced by the host are called antioxidant enzymes and antioxidant came from dietary intake.

Under normal conditions, antioxidants produced by the host are good enough to keep the levels of free radicals in check.

Oxidative stress, a major cause of many chronic ailments is a result of overexpression of free radical in the body that overwhelms the levels of antioxidants enzymes. In other words, free radicals have started a chain oxidative reaction that has not been stopped, leading to oxidative stress.

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.

They may have positive, negative or zero charges. The unpaired electrons cause free radicals to be highly chemically reactive to induce oxidative stress that damage the cell structures, protein and lipid and the alternation of DNA.

According to the study by the Heinrich-Heine-Universität Düsseldorf, Universitätsstr in the examination of the risk oxidative stress in Alzheimer disease, "The protective role of antioxidants against the development of several diseases and conditions recognized as risk factors for Alzheimer's disease (AD)" and "A variety of health behaviors, including an adequate supply of antioxidant micronutrients with the diet might help preventing AD directly, or indirectly through the mitigation of pathologic conditions associated with AD, such as vascular disease and diabetes".

Therefore, by enhancing antioxidant status in the body through regular physical activity and intake of fruits and vegetables which contain a high amount of dietary antioxidant to offset the free radical toxic effects, the risk of oxidative stress can be reduced substantially

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

In the concern of oxidative stress disorder that leads to age-related and gradual loss of corneal endothelial cells resulting in corneal edema and loss of vision. researchers at the Harvard Medical School, Boston investigated the antioxidant activity of sulforaphane (SFN) and D3T by targeting Nrf2-ARE in Fuchs endothelial corneal dystrophy (FECD).

Where Nuclear factor-like 2 (Nrf2-ARE) is a transcription factor which regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.

In human corneal endothelial cell lines (CEC) induced oxidative stress with tert-Butyl hydroperoxide (tBHP), injection of SFN decreased CEC apoptosis by 55% in the control group and by 43% in tBHP-treated specimens.

SFN enhanced nuclear translocation of Nrf2 in FECD specimens and decreased p53 gene in the cancer cells line under oxidative stress.

Where p53 is a protein that regulates the cell cycle and hence functions as a tumor suppression.

Futhermore, application of SFN protected the cell integrity and viability against injection of tert-Butyl hydroperoxide (tBHP), causing overexpression of free radicals in the initiation of oxidative stress.

These results clearly suggested SFN significantly promoted major ARE-dependent antioxidants and ameliorated oxidative stress-induced apoptosis in FECD.

Dr. Ziaei A said, " targeting Nrf2-ARE pathway may arrest degenerative cell loss seen in FECD".

Most importantly, in the review the anti-oxidant properties of isothiocyanates (ITCs), researchers found that The ITCs induces Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibits antitumor activity at post-initiation phase,

In other words, ITCs inhibited the substances which can cause cancers and cancers in the early and late stages.

In a dose-dependent manner, ITCs inhibit the cell viability of human cancer cell lines through its antioxidant activity.

The review showed support to the use of isothiocyanates such as sulforaphane for cancer and cardiovascular diseases treatments.

Taken altogether, there is no doubt that bioactive compound Isothiocyanates processed a significant antioxidant property may be used for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of large sample size and multicenter human study.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.Reference
(1) Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment by Ziaei A1, Schmedt T, Chen Y, Jurkunas UV.(PubMed)
(2) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(3) Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression by Prawan A1, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN.(PubMed)
(4) Oxidative stress and risk factors for Alzheimer's disease: clues to prevention and therapy by Polidori MC. (PubMed)