Phytochemicals Phytic Acid Anti Cancers Potency

By Kyle J. Norton

Phytic acid (Inositol hexaphosphate) may have a potential effect in reducing the risk and treatment of cancers, some scientists suggested.

Cancer is a class of chronic diseases associated with the irregular cells growth that starts in the cells of the inner lining of a tissue or organ caused by DNA alternation.

At the advanced stage, cells of the invasive tumor may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.

Some cancers can be slow-growth such as prostate and colon cancer.

Primary cancer at stage 0 and 1 do not induce any symptoms. However, at the later stage, a larger size tumor can suppress the nearby tissue and nerve cells leading to localized and severe symptoms and pain, depending on the types of cancer.

According to the statistics, in the US, the number of new cases of cancer(cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).

Cancers which are diagnosed in the early stage have a 5 years survival rate closed to 100%. Therefore, the annual examination may be necessary for people who are classified to have a higher risk of cancer development.

The causes of cancer are unknown. researchers cannot explain why people with the same healthy condition, family history in the same family, some are susceptible to the onset of the disease while others do not.

Either they can explain why people who carry some of the risk factors associated with the development of cancer never have cancer, while others having no risk factor are diagnosed with cancer.

Conventionally, treatment of cancers completely depends on the types and grade of cancer. Some people with cancer at the early stage may only need one treatment. But most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.

Phytic acids (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

With an aim to find a natural ingredient for the p[revention and treatment of cancers without inducing side effects, researchers examine the anticancer effects of phytic acid (IP6).

In vitro and in vivo phytic acid (IP6) exerted a strong anticancer activity by inhibiting the tumor growth and cell proliferation in a series of cancer cell lines, including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma and glioblastoma.

The efficacy of IP6 was probably associated with the promoted antioxidant production, improved signal transduction, enhance functions of the NK-cells and exhibited cell cycle arrest and activated proteins associated with cell death programming.

Furthermore, in the finding, the proper role for the treatment of cancer researchers looked into the concentration of IP6 and its lower phosphorylated forms (IP(1-5)),

At the 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) showed a potential activity in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation, similar to those of the previous study.

In vivo and in vitro, exogenously administered IP6 and internalized, IP6 and IP(1-5) inhibited cell growth.

Moreover, researchers found that application of IP6 not only decreased cellular proliferation but also causes differentiation of malignant cells often resulting in a reversion to normal phenotype. 

The results strongly indicated that IP6 inhibits the cancer cell lines through a number of mechanisms, including cell cycle regulatory genes, differentiation genes, and tumor suppressor genes.

Taken all together, phytic acid (IP6) may be considered an anti-cancer bioactive compound for the prevention and treatment of cancer with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) [Phytic acid--anticancer nutriceutic].[Article in Polish] by Nawrocka-Musiał D, Latocha M.(PubMed)
(2) IP6: a novel anti-cancer agent by Shamsuddin AM, Vucenik I, Cole KE.(PubMed)

Phytochemical Allicin, the Potent Anti Osteosarcoma Bioactive Supplement

By Kyle J. Norton

Phytochemical allicin isolated from garlic may be used for the prevention and treatment of osteosarcoma with no side effects, some scientists suggested.

Osteosarcoma is a bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with the genetic syndromes. In other words, the disease is the result of the conditions associated with inherited mutated genes from the parent.

However, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation also use play a major role in many adult cancers.

According to the statistic,  in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are reported each year. and children and teens younger than 20 accounts for half of the numbers.

Dr. James J. Morrow, the lead scientist in the study of genetic risk of osteosarcoma wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life" 

And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)"

These results strongly suggested that young teenagers with the genetic syndrome are more likely to be infected by the disease, compared to others.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find a natural ingredient for the treatment of osteosarcoma with no side effects, researchers at the Wenling City Chinese Medicine Hospital looked into the anti osteosarcoma activity of the main biologically active compound derived from garlic.

The combined treatment significantly suppressed the invasion, motility and colony formation ability and activated the protein associated with a pro-apoptotic activity, compared to the lone treatment group.

Furthermore, in vivo.artesunate and allicin also inhibited the tumor growth and cell proliferation

Dr.Jiang W, the lead scientist said, "artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis".

Moreover, in the examined the effects of diallyl sulfide (DAS) derived from allicin in vitro and vivo on the proliferation of human osteosarcoma MG-63 cells, researchers found that in vivo, the nude mice MG-63 cells tumor-bearing model after twenty-one days treatment with DAS inhibit proliferation of MG-63 cells in a time- and concentration-dependent manner.

DSA groups (different concentrations) showed a significantly reduced the expression levels of VEGF mRNA, associated with stimulating the formation of blood vessels. compared with those in the control group.

At the dose of 20 and 40 μg/mL, cells migration was significantly lower in the DAS groups (91.4±8.3 and 81.8±7.4, respectively) compared to the control group (150.4±14.7, both).

Also at the dose of 20 and 40 μg/mL, DAS also decreased the microvessel density (MVD) of MG-63 tumor-bearing tissue.

Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of osteosarcoma.

However, intake of allicin as a form of supplement should be taken with extreme care to prevent overdose toxicity

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo by Jiang W, Huang Y, Wang JP, Yu XY, Zhang LY.(PubMed)
(2) Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells by Hu Y, Chen L, Yi C, Yang F, Chen J.(PubMed)

(3) Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies by James J. Morrowa and Chand Khannab. (PMC)

Ginger, the Potent and Natural Therapy for Rheumatic Diseases

By Kyle J. Norton

Scientists may have found a pungent and kitchen spice for the prevention and treatment of diseases associated with rheumatism, according to studies.

Rheumatism is autoimmune and inflammatory diseases marked by inflammation and pain in the joints, muscles, or fibrous tissue, especially rheumatoid arthritis.

In other words, rheumatic diseases are a medical and chronic condition characterized inflammation that affects your joints tendons, ligaments, bones, and muscles, including a group of diseases associated with arthritis.

Depending on the types of rheumatic diseases, conventional treatment may include medication for reducing the symptoms, physiotherapy and stress management. The aim of the treatment is to alleviate pain and improve the quality of life. Sadly, none of the drugs has been found safe; all are known to produce from mild to serious side-effects.

Most common symptoms of rheumatic diseases are joint pain, reduced motion in a joint, particularly, joints inflammation that induces swelling, redness, on the affected area.

If you experience some of the above symptoms, you may have rheumatic diseases, please make sure you check with your doctor to rule out the possibility.

There is no single cause of rheumatic diseases. Researchers believe groups of factors such as genes and environmental influences may be associated with the onset of the diseases, including the increase in age, gender, family history, exposure to environmental toxic substance and smoking.

However, the most common risk factor of rheumatic diseases in the Western world is obesity. Dr. the lead scientist, in the examination of the risk of obesity for the onset of rheumatic diseases, said, "The growing body of evidence recognizing the adipose tissue (AT) as an active endocrine organ secreting bioactive mediators involved in metabolic and inflammatory disorders, together with the global epidemic of overweight and obesity, rise obesity as a hot topic of current research".

" The chronic state of low-grade inflammation present in the obese condition and the multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of several inflammatory conditions including rheumatic autoimmune and inflammatory diseases".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural ingredient or whole food for the prevention and treatment of rheumatic autoimmune and inflammatory diseases with no side effects, scientists at the Odense University examine the traditional use of ginger against rheumatism.

The study included 56 patients (28 with rheumatoid arthritis, 18 with osteoarthritis and 10 with muscular discomfort) randomly assigned to the use of powdered ginger against their afflictions.

Amongst the arthritis patients more than three-quarters experienced, to varying degrees, relief in pain and swelling. All the patients with muscular discomfort experienced relief in pain.

None of the patients reported adverse effects during the period of ginger consumption which ranged from 3 months to 2.5 years.

Further analysis of the results, researchers found that ginger exerts the similar effects of that of conventional medicine as an important mediator of inflammation.

Dr. Srivastava KC, the lead scientist wrote in the final report, "at least one of the mechanisms by which ginger shows its ameliorative effects could be related to the inhibition of prostaglandin and leukotriene biosynthesis., i.e. it works as a dual inhibitor of eicosanoid biosynthesis".

Additionally, compared to conventional medicine such as non-steroidal anti-inflammatory drugs and corticosteroids which treat rheumatic diseases through inhibiting the cyclooxygenase associated with the symptoms of inflammation and pain, ginger demonstrated the similar effects and improve quality of the life in patients with rheumatic diseases, without inducing any side effects during the course of the experiment.

These results clearly suggested that ginger may be considered a functional food for the prevention and treatment of rheumatism with no adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders by Srivastava KC1, Mustafa T. (PubMed)
(2) Ginger (Zingiber officinale) and rheumatic disorders by Srivastava KC1, Mustafa T. (PubMed)
(3) Obesity as a Risk and Severity Factor in Rheumatic Diseases (Autoimmune Chronic Inflammatory Diseases) by Elisa Gremese,1 Barbara Tolusso,1 Maria Rita Gigante,1 and Gianfranco Ferraccioli. (PMC)

Celery, the Best Anti Chronic Inflammatory Disease Functional Veggie

By Kyle J. Norton

Celery may have a profound and positive effect on the prevention and treatment of chronic inflammatory diseases, some scientists found.

Inflammation is a natural reaction to a systematic immune response which protects our body against the stimuli ot invasive pathogens.

Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines with an aim to kill off the microorganism which tries to enter the body through the wound.

Chronic inflammation is a condition of low-grade inflammation adopted by the immunity caused by the immune inability to kill off all invaders in the acute phase of infection.

Some researchers in the examine the immune evolution over thousands of year suggested that the immune system has evolved to destroy the foreigner pathogens after entering in specific time within 3 -8 weeks, otherwise, it will adapt to the change.

Chronic inflammation also is an autoimmune disease caused by the immune system mistakenly attacks the bodily tissue.

Epidemiological studies suggested that aging that causes low production of sex hormone, being obese and obese, and smoking are associated with the early onset of chronic inflammatory diseases.

Some researchers suggested that out of a number of risk factors, a poor diet in long-term is one of the major cause of the chronic inflammatory diseases.

Dr. Anne M. Minihane, the lead author in the examine the risk of low-grade inflammation in diet composition and health said, " the ability of diet to positively modulate inflammation and provide the much-needed evidence to develop research portfolios that will inform new product development and associated health claims".

The statement clearly suggested that people who follow a healthy diet pattern with high fruits and vegetables and whole grain and low saturated and trans fat, red meat and processed food are less likely to be infected by chronic inflammatory diseases.

Celery is a species of Apium graveolens, belong to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

With an aim to find a natural whole food for the prevention and treatment of chronic inflammatory disease, researchers looked into the group of flavones that have reported anti-inflammatory activities, and examined the ability of flavone-rich foods to reduce inflammation.

Celery extracts, with the anti-inflammatory activities and rich in flavone aglycones, was selected for the study.

Celery diets with different glycoside or aglycone contents were formulated and absorption was evaluated in mice fed with 5 or 10% celery diets.

Intake of deglycosylation was found to increase the absorption of dietary flavones in vivo and modulates inflammation by reducing TNF-α, the proinflammatory cytokines and NF-κB, which regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.

The results suggested that celery extract rich in flavones may have a potential for the treatment and prevention of inflammatory diseases.

Additional differentiation of the anti-inflammatory and immunomodulatory activity in-vitro and in-vivo of the compound flavonoids found abundantly in celery, researchers launched an evaluation to examine the effects of the ethanol/water (1:1) extract of the leaves of Apium graveolens var. dulce (celery) on iNOS expression and NO production in a tested macrophage cell line stimulated for 24 h with Escherichia coli lipopolysaccharide (LPS).

Where the inducible nitric oxide synthase (iNOS) is one of the direct consequences of the inflammatory process and overproduction of NO is considered a pro-inflammatory mediator that induces inflammation.

In vitro, treatment of the extract and apiin showed significant inhibitory activity on nitrite (NO) production and iNOS expression observed by the tested cell line assay.

Interestingly, the extract exerted anti-inflammatory activity in-vivo (ID50 730 microg cm(-2)), with a potency seven-times lower than those of indomethacin (ID50 93 microg cm(-2)), the non-steroidal anti-inflammatory drug used as references.

The finding clearly suggested the inhibitory activity of the extract and apiin in-vitro on iNOS expression and nitrite production.

Taken altogether, celery may be considered a functional food for the prevention and treatment of acute and chronic inflammatory diseases without inducing any side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Flavone deglycosylation increases their anti-inflammatory activity and absorption by Hostetler G1, Riedl K, Cardenas H, Diosa-Toro M, Arango D, Schwartz S, Doseff AI. (PubMed)
(2) An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties by Mencherini T1, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G.(PubMed).
(3) Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products by Whitehouse MW1, Butters DE. (PubMed)
(4) Low-grade inflammation, diet composition and health: current research evidence and its translation by Anne M. Minihane, 1 ,* Sophie Vinoy, 2 Wendy R. Russell, 3 Athanasia Baka, 4 Helen M. Roche,5 Kieran M. Tuohy, 6 Jessica L. Teeling, 7 Ellen E. Blaak, 8 Michael Fenech, 9 David Vauzour, 1Harry J. McArdle, 3 Bas H. A. Kremer, 10 Luc Sterkman, 11 Katerina Vafeiadou, 12Massimo Massi Benedetti, 13 Christine M. Williams, 14 and Philip C. Calder. (PMC)

Avocado, the Best Fruit for Skin health

By Kyle J. Norton

Researchers may have found a whole fruit for the promotion of skin health with no side effects, according to studies.

Skin, a large organ of the body protects our tissue and organs against the invasion of pathogens and fluid loss.

There are many causes of skin damage. Sun exposure is the most common cause of skin damage. Other causes of skin damage include smoking cigarettes, drinking too much alcohol, extreme temperatures, and exposure to toxic chemicals and pollutants in the air outside.

Some researchers suggested that free radicals bombard our body daily are also associated with skin damage in the modern world.

Free radicals are unstable molecules with the unpaired electron on the outer ring. In order for them to become balanced, free radical either donates or intercept an electron from another stable molecule, leading to a chain reaction that can not be stopped until the outer ring election is paired or inhibited by antioxidant.

In fact, free radical formation occurs continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions, they can be generated by our bodies such as the process of metabolism and exogenous sources such as pollution, alcohol, tobacco smoke.

Free radicals can affect our skin in different ways, including the alternation of the DNA, damage of lipid membrane, collagen structures, and inducing photoaging and cancer.

Dr. Borut Poljšak, in the study "Free Radicals and Extrinsic Skin Aging" wrote, "Extrinsic skin damage develops due to several factors: ionizing radiation, severe physical and psychological stress, alcohol intake, poor nutrition, overeating, environmental pollution, and exposure to UV radiation (UVR)". and 

"The only protection of our skin is in its endogenous protection (melanin and enzymatic antioxidants) and antioxidants we consume from the food (vitamin A, C, E, etc.)".

These results suggested that although free radical can induce the early onset of skin damage and aging, providing our body with enough antioxidants from the food sources is the best way to counter the process.

Avocado is commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

On finding a natural ingredient or essential oil which has a potential effect on skin health without inducing any side effects, researchers explored the effects of various avocado oils on collagen metabolism.

In skin rats fed diets containing 10% (w/w) of the tested oils, researchers found the akin protective effects were totally depended on the types of avocado oil.

Rats fed the unrefined avocado oil extracted with hexane from the intact fruit, including unsaponifiables or the avocado seed oil, showed a significant increase in soluble collagen content in skin, though total collagen content was not affected.

The increased soluble collagen content was attributed to the inhibition of lysyl oxidase activity whose increment is associated with the oxidative stress induced by chronic exposure to skin harmful substances.

The active factor which protects the skin health was found to be present in the unrefined avocado oil and probably originated from the avocado seed, observed by the collagen metabolism which is affected only by fractions containing lipids fraction from the seed.

In order to illustrate the effects of avocado oil on skin health, researchers evaluated the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natural, on incisional and excisional cutaneous wound models in Wistar rats.

On the 14 days of application on the wound, 50% SSFAO or avocado oil demonstrate a significant increase in percentage wound contraction and reepithelialization, compared to the petroleum jelly control.

The treatment group also displayed the increase in anti-inflammatory activity, density of collagen, and tensile strength, compared to control groups.

This efficacy of the 50% SSFAO or avocado oil was attributed to the contents of the bioactive compounds, oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%).

Dr. de Oliveira AP, the lead scientist wrote in the final report, "When used in natural or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process".

In skin exposure to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, reduced significantly UV-induced cellular damage, through increasing cell viability, decreased the secretion of IL-6, a pro-inflammatory cytokine, and PGE(2) in mediated the inflammation process.

Taken altogether, avocado processed abundantly bioactive compounds may be considered a functional food for the promotion of skin health without inducing any side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(4) Free Radicals and Extrinsic Skin Aging by Borut Poljšak 1 and Raja Dahmane. (PMC)

Allyl isothiocyanate, the Potential Anti Liver Cancer Bioactive Ingredient

By Kyle J. Norton

Scientists may have discovered a bioactive compound isolated from horseradish for the prevention and treatment of liver cancer, according to the studies.

Liver cancer is a medical condition caused by irregular cell growth in the liver. Most cases of primary liver cancer start in the cells on the surface of the inner lining of the liver. At the early stage of liver cancer, the patient may not experience any symptoms.

However, at the later stage, the overgrowth of tumor in the liver may suppress the nearby tissue and nerve cells, leading to localized symptoms and severe pain.

According to the world standard statistics, the onset of liver cancer rate is 10.1 per 100,000 people (15.3 in males and 5.3 in females). 

The highest mortality rates occurred observed in the East Asian countries probably due to the high incidence of hepatitis virus. 

The world standardized mortality rate for liver cancer is 9.5 per 100,000 people (14.3 in males and 5.1 in females).

The most common risk factor of liver cancer is associated with the hepatitis viral infection. People with chronic infection with HBV or HCV are found in the high percentage of patients with liver cancer.

Dr. Marc Ringehan, in the concern of the high percentage of hepatitis viral carriers in the risk of liver cancer said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC)" and "Owing to its high incidence and resistance to treatment, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases".

" (Particularly, hepatitis B virus infection can promote HCC development without prior end-stage liver disease".

These results clearly reaffirmed the risk of liver cancer in population carrying the hepatitis B and C.

In fact, people who are chronically infected with hepatitis B have a 25% to 40% lifetime risk of developing liver cancer.

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

With an aim to find a natural compound for the prevention and treatment of liver cancer, researchers looked into Allyl isothiocyanate (AITC), a bioactive ingredient and N-acetylcysteine (NAC) conjugate anti-liver cancer effects through the SK-Hep1 cells line.

Application of AITC exerted a significant activity in the inhibition of genes and proteins associated with suppressing tumor cell migration and activating cytokines and chemokines to regulate tissue remodeling.

At 25% for 10 micros, AITC suppressed SK-Hep 1 cell proliferation in a dose-dependent manner.

At 0.1-5 microM, AITC inhibited a significant MMP-2/-9 expression in SK-Hep1 cells compared with controls associated with the decrease of MMP-2/-9 messenger RNA levels.

However, AITC inhibited cancer cell adhesion and invasion much less potently compared to NAC-AITC.

Dr. Hwang ES and colleagues at the Seoul National University, said, "NAC-AITC at 5 microM caused excellent inhibition of cell migration for 48 hrs. These results demonstrate the potential of AITC and NAC-AITC as chemopreventive agents".

Taken altogether, Phytochemical Allyl isothiocyanate may be used for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells by Hwang ES1, Kim GH. (PubMed)
(2) Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells by Hwang ES1, Lee HJ. (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)

Phytochemical Sulforaphane (Dithiolthiones) Kills Cervical Cancer Cells, According to Studies

By Kyle J. Norton

Scientists may have found a bioactive compound isolated from cruciferous vegetables for the prevention and treatment of cervical cancer with no side effects, according to studies.

The cervix is an opening passage in the center of the ectocervix, that connects the uterus to the vagina in female reproductive organs. Cervix acts as a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.

Cervical cancer is a medical condition caused by irregular and disordered cell growth in the tissue of the cervix.

Most cases of cervical cancer start in the cells on the surface of the inner lining the cervix. At the early stage, most patients do not experience any symptoms.

However, at the later stage, the overgrowth tumor may suppress the nearby blood vessels and nerve tissue, leading abnormal bleeding and severe abdominal pain.

At this stage, cancerous cells from cervix also can travel a distance away to infect other healthy tissue and organ, through lymph and blood circulation, causing the secondary metastasis.

Most common cervical metastasis includes the vagina, the uterus, the uterus, the tissue nearby lymph nodes in the pelvis, back of the abdomen tissue and ligaments around the cervix and uterus  

According to the statistic, cervical cancer is most often diagnosed between the ages of 35 and 44 and only 15% of cervical cancers are diagnosed in women over age 65.

The five years survival rate of invasive cervical cancer is 92% if diagnosed in the early stages.

What causes cervical cells DNA alternation? Researchers do not know. But researchers do know that immune system deficiency, smoking, the increase in age, long-term use of oral contraceptives and exposure to diethylstilbestrol are some of the prevalent risk factors associated with the onset of the disease.

Some researchers also suggested women who have several sexual partners or often change of sexual partners are at increased risk of infected by the Human papillomavirus (HPV), one of the major cause of cervical cancer.

Dr. Diane Cooper, the lead scientist in the cancer researcher in the examine the sexual activity in the risk of cervical cancer of among South African women wrote, "cervical cancer risk is associated with increased sexual activity. Initiatives to encourage later commencement of sex, and limiting the number of sexual partners would have a favorable impact on the risk of cancer of the cervix and other sexually transmitted infections".

These results clearly suggested that women who are sexually active and have a number of sexual partners should take extreme precautions to protect themselves against HPV infection.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

On finding natural chemoprevention which holds great potential for cancer management as lower, clinically tolerable doses of individual agents for the treatment of cervical cancer, the cancer team at the Manipal University examined the effect of combination treatment of sulforaphane (SFN) and eugenol on HeLa cells.

Injection with variable dose combinations of SFN and eugenol showed a significant effect in inducing cell cytotoxicity and apoptosis at the lower and synergistic effect at higher sub-lethal doses to the cancer cells.

Futhermore, application of chemo drugs gemcitabine combined with the low- and high-dose of SFN combinations showed no significant cell death at lower doses compared to that of cell cytotoxicity in gemcitabine alone.

These results clearly suggested that SFN can only elevate the efficiency and lower the dose of certain chemo drugs which act on certain pathways in inducing cytotoxicity and cell death with decreasing side effects.

Additional examination of the effect of SFN and eugenol combinations researchers found that SFN significantly inhibits the expression of the proteins associated with cell proliferation and production of inflammatory cytokines.

Dr. Hussain A, the lead scientists in the final report wrote, "2 (or more) chemopreventive agents can act antagonistically or synergistically necessitating elucidation of possible mechanistic interactions for favorable and reliable outcomes of dietary components in the field of cancer prevention".

Compared to chemo drugs, injection of sulforaphane alone exerted a strong effect in inducing dose-dependent selective cytotoxicity in HeLa cells without causing harm to the to normal cells.

The finding emphasized that the bioactive compound processes a safe cytotoxicity profile compared to conventional chemo medicine.

Also, sulforaphane alone was found to expresse its efficacy through analysis of genes similar to that of SFN and eugenol combination.

In human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells, SFN inhibited the viability of both HeLa and HepG2 cells by inducing apoptosis, observed by the formation of apoptotic bodies and the accumulation of the sub-G1 phase.

In-depth differentiation of SFN activity, researchers discovered that SFN not only induces cell death through the cancer cells cycle arrest but also activates the genes associated with the programming cell death and cell apoptosis by blocking the expression of cell proliferative proteins.

Taken altogether, sulforaphane SFN may be considered a chemo and natural medicine for the prevention and combined with certain primary medicine for the treatment of cervical cancer with a reduced side effect through lowering the dose of the applied chemo drug.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Concurrent sulforaphane and eugenol induces differential effects on human cervical cancer cells by Hussain A1, Priyani A, Sadrieh L, Brahmbhatt K, Ahmed M, Sharma C.(PubMed)
(2) Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells by Sharma C1, Sadrieh L, Priyani A, Ahmed M, Hassan AH, Hussain A.(PubNed)
(3) Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3 by Park SY1, Kim GY, Bae SJ, Yoo YH, Choi YH.(PubMed)
(4) Determinants of sexual activity and its relation to cervical cancer risk among South African Women by Diane Cooper,1 Margaret Hoffman,1 Henri Carrara,1 Lynn Rosenberg,2 Judy Kelly,2Ilse Stander,3 Lynnette Denny,4 Anna-Lise Williamson,5,6 and Samuel Shapiro. (PMC)