Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday, 13 January 2019

Herbal Arctostaphylos uva-ursi, the Anti Endometrial Cancer Functional Remedy

By Kyle J. Norton

Scientists may have found a medicinal plant for the prevention and treatment of endometrial cancer with no side effects, according to the study

The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particularly in the menstrual cycle.

Endometrial cancer is a late adulthood cancer characterized by cells growth irregularly in the tissue of the endometrium.

Most cases of endometrial cancer start in the cells on the surface of the inner lining of the endometrium. At the 0 stage, due to the small size of the tumor, most patients do not experience any symptoms.

However, at the later stage, the large tumor can suppress to the nearby blood vessels and nerve cells, leading to bleeding and severe localized pain.

At this stage, cancer cells in the endometrium can also travel a distance away from the endometrium to infect other healthy tissue and organs, leading to a secondary metastasis. According to statistic, endometrial cancer metastasizes to the lungs 20–25% of the time, more than any other gynecologic cancer.

The cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer. However, in the US, endometrial cancer is the most common cancer of the female reproductive organs. Every year, approximately over About 63,000 new cases of uterus cancer are diagnosed, causing the death of 11,000 women.

The 5-year survival rates for white and black women with the disease are 84% and 62% respectively.

At the invasive stage, the survival rate is 16%.

Epidemiological studies suggested the increase in age, family history, certain medical conditions such as diabetes, diagnosed with breast or ovarian cancer and endometrial hyperplasia in the past are associated with the onset of the diseases.

Some researchers suggested that a poor diet is a critical risk factor of endometrial cancer. Dr. Fulvio Ricceri and colleagues in the review of diet and endometrial cancer, wrote, "Women in the highest quintile of vegetable intake had a statistically significantly lower endometrial cancer risk. Women with high adherence to the MD had a risk of endometrial cancer that was about half that of women with low adherence to the MD.

And, " high vegetable intake, adherence to the MD, and a low DII are related to lower endometrial cancer risk, with several putative connected biological mechanisms that strengthen the biological plausibility of this association".

These results strongly suggested the risk of endometrial cancer is reduced by many folds for women who follow a healthy diet with high fruits and vegetable and low saturated and trans fat, red meat and processed foods.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavones.

With an aim to find a natural ingredient for the treatment of endometrial cancer with no side effect, researchers at the Fujita Health University examined the ursolic acid, a pentacyclic triterpene acid, extracted from bearberry in the growth of endometrial cancer cell SNG-II.

Ursolic acid strongly inhibited the growth of SNG-II cells in a dose- and time-dependent manner.

The chemical compound induced cancer cells apoptosis through cell degradation.

At the At 25 and 50 microM strength, ursolic acid induced marked increases in caspase-3 activity associated with cells apoptosis to approximately 5-fold that of control cells in a time- and dose-dependent manner.

Ursolic acid treatment also resulted in cleavage of poly (ADP-ribose) polymerase, the enzyme involved in many functions of the cell, including the repair of DNA damage.

Interestingly, after ursolic acid treatment, the levels of proteins involved anti-apoptotic (Bcl-2 protein) was decreased and tumor suppression (Bax expression) was enhanced.

Dr. the lead scientist said, "ursolic acid induced apoptotic processes in the endometrial cancer SNG-II cell line through mechanisms involving mitochondrial pathways and Bcl-2 family proteins".

Additionally, the evaluated ursolic acid effect in the growth of HEC108 cells showed that ursolic acid induced cancer cells apoptosis through several mechanisms, including
* Inducing cancer cells degradation.

*Similar to that of endometrial cell SNG-II cells, ursolic acid-treated HEC108 cells showed that exposure at 50, 75 or 100 microM induced marked increases protein associated with the pro-apoptotic activity (after 24 h) to 5.00, 11.76 or 12.75 times that of control levels. These results indicated Levels of the pro-apoptotic activity (cleaved caspase-3) increased in a time- and dose-dependent manner.

* Similar to that of endometrial cell SNG-II cells, ursolic acid treatment also resulted in cleavage of poly(ADP-ribose) polymerase in a dose-dependent manner.

Finally, researchers also showed that after ursolic acid treatment, the levels of proteins involved anti-apoptotic (Bcl-2 protein) was decreased and tumor suppression (Bax expression) was enhanced similar to that of the SNG-II cells.

Taken together, Arctostaphylos uva-ursi processed high amount ursolic acid may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of endometrial cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells by Achiwa Y, Hasegawa K, Udagawa Y.(PubMed)
(2) Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells by Achiwa Y, Hasegawa K, Komiya T, Udagawa Y.(PubMed)
(3) Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk by Fulvio Ricceri,1,2 Maria Teresa Giraudo,3 Francesca Fasanelli,4 Dario Milanese,3Veronica Sciannameo,2 Laura Fiorini,4 and Carlotta Sacerdote. (PMC)

Herbal Arnica, Speed Up Wound Healing with No side Effects

By Kyle J. Norton

Scientists may have found a natural plant for speeding up wound healing with no side effects, according to studies.

Wound healing is a natural process to restore the damage of injured tissue.

There are number stages of wound healing. The first and second phases are to stop bleeding and protect the tissue against infection through proteins associated with the production of blood palettes to cover the wound and inflammatory cytokines to kill off all the invasive pathogens, respectively.

The third phase is the proliferation phase in which the wound is filled, the margin of the wound is reduced and the wound is completely covered.

The 4 phase is the maturation phase in which the new tissue slowly recover the strength and flexibility.

However, any interruption of the wound healing processes such as untreated overproduction of inflammatory cytokines, reduced or inadequate blood supply to the wound can lead to the formation of scars or chronic wound.

According to the statistic, in the US, 6.5 million people suffer from wounds that are not properly healing, Chronic wounds are more common in elderly people or people with high blood pressure, obesity, particularly in people with diabetes.

If you have a wound that does not heal in a specific time frame, please check with your doctor right the way.

Dr. Krister Järbrink and colleagues in the examined the complications of chronic wounds wrote, " Complications of chronic wounds include infection such as cellulitis and infective venous eczema, gangrene, hemorrhage and lower-extremity amputations. Chronic wounds lead to disability and disability worsens wound outcomes resulting in a vicious cycle".

Herbal Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia. The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.

Besides helenalin as it main ingredient used as an anti-inflammatory agent, the herb also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

On finding the natural compound for the treatment of wound healing, researchers examined the composition of a herbal formula in topical formulations for the decrease of bruising and muscle pain in NIH 3T3 fibroblasts.

The ethanolic preparation contains the equal parts of Arnica montana 4x, Calendula officinalis 4x, Hypericum perforatum 4x and Symphytum officinale 6x (0712-2).

Preparation (0712-2) exerted a stimulating effect on fibroblast migration (31.9%) vs 14.7% with succussed solvent (0712-1) at 1:100 dilutions (p < 0.001).

Preparation (0712-2) at a dilution of 1:100 promoted in vitro wound closure by 59.5% and differed significantly (p < 0.001) from succussed solvent (0712-1), which caused 22.1% wound closure.

The findings suggested the formula exerts low potency in vitro wound closure potential in NIH 3T3 fibroblasts.

Furthermore, researchers at the Johann Wolfgang Goethe-Universität, Frankfur evaluated the Arnica D4 as efficacious as diclofenac in relation to symptoms and wound healing after foot surgery.

The randomized double-blinded, parallel-group study (GCP-standard), included Arnica D4 10 pillules (taken orally, 3 times per day) and diclofenac sodium, 50 mg (taken orally, 3 times per day) in 88 patients 4 days after hallux valgus surgery.

Arnica D4 and diclofenac were equivalent for wound irritation (lower margin of the 95% CI on day 4: 0.4729 for rubor; 0.3674 for swelling; 0.4106 for color) and patient mobility (0.4726).

Descriptive analysis showed the superiority of Arnica D4 with respect to patient mobility (p = 0.045). and pain, Arnica D4 was inferior to diclofenac (lower margin of the 95% CI 0.026).

These results indicated that the efficacy of Arnica is compared to that of conventional medicine for the treatment of wound healing without inducing side effects. However, Arnica D4 is 60% cheaper than diclofenac.

Taken altogether, herbal Arnica may be used for the treatment of wound healing orally without inducing any side effects, pending a large sample size and multicenter study.

References
(1) A homeopathic remedy from arnica, marigold, St. John's wort and comfrey accelerates in vitro wound scratch closure of NIH 3T3 fibroblasts by Hostanska K, Rostock M, Melzer J, Baumgartner S, Saller R.(PubMed)
(2) Efficacy of Arnica montana D4 for healing of wounds after Hallux valgus surgery compared to diclofenac by Karow JH, Abt HP, Fröhling M, Ackermann H.(PubMed)
(3) Effects of microcurrent application alone or in combination with topical Hypericum perforatum L. and Arnica montana L. on surgically induced wound healing in Wistar rats by Castro FC, Magre A, Cherpinski R, Zelante PM, Neves LM, Esquisatto MA, Mendonça FA, Santos GM. (PubMed)
(4) Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review by Krister Järbrink,1 Gao Ni,1 Henrik Sönnergren,2 Artur Schmidtchen,3 Caroline Pang,4Ram Bajpai,1 and Josip Car. (PMC)

Herbal Burdock, the Anti-Chronic Cough Functional Remedy

By Kyle J. Norton

herbal Burdock may have potential and positive effects on the treatment of chronic coughing, according to studies.

The antitussive effect is a cough-suppressive activity with the use of substances, including herb, medication.

Coughing is a natural defense of the human body by expelling mucus, microbes, and foreign particles from the respiratory tract, therefore protecting the lungs from infection and inflammation.

A chronic cough that lasts longer than a few weeks can be a result of a wide range of diseases from hay fever, common cold to bronchitis to pneumonia.

Some chronic cough is associated with some underlying diseases, including asthma gastroesophageal reflux disease, chronic bronchitis, bronchiectasis.

Some researchers suggested that long-term use of ACE inhibitors and smoking are 2 most common risk factors that have been found to associate with the onset of a chronic cough, epidemiologically.

Dr. Kiernan KE and colleagues in the examined the effect of smoking on the risk of a chronic cough, wrote, "The association of cough prevalence with current smoking habits and with lower respiratory tract illness in childhood found in the survey at age 20 was confirmed and in each instance appears to have increased in strength over the 5 years".

And, "The prevalence of a cough increased between the ages of 20 and 25 among those who smoked throughout or who started to smoke during this period".

These results strongly suggested if you expose your children with second-hand smoke and start to smoke at age of 20, you are at a higher risk to have a chronic cough.

Burdock is plant in the group of biennial thistles, genus Arctium,belonging to the family Asteraceae, native to the Euro.

The herbal plant has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.

The herb contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

With an aim to find a natural remedy for the treatment of coughing researchers investigated polysaccharide isolated from herbal Burdock influence on the experimentally induced cough.

The purified and/or modified polysaccharides from the flowers and plants exhibited statistically significant cough-suppressing activity higher than that of the non-narcotic drug used in clinical practice to treat coughing.

However, compared to the polysaccharide from marshmallow, the cough-suppressing activity of herbal Burdock was lower in the treatment of an acute cough.

Futhermore, in cat study to the examine the effect of a low-molecular-weight fructofuranan of the inulin-type isolated from the herb, researchers found that the fructan was found to be equally active as some non-narcotic, synthetic preparations used in clinical practice to treat coughing.

And, in mitogenic and comitogenic tests, the fructans biological response was comparable to that of the commercial Zymosan immunomodulator.

The finding clearly indicated herbal Burdock processes an antitussive effect similar to or better than that of commercial and over the counter medicine for the treatment of a cough.

Taken altogether, herbal Burdock may be considered a functional remedy for the prevention and treatment of cough with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The antitussive activity of polysaccharides from Althaea officinalis l., var. Robusta, Arctium lappa L., var. Herkules, and Prunus persica L., Batsch by Sutovska M, Nosalova G, Franova S, Kardosova A.(PubMed)
(2) A biologically active fructan from the roots of Arctium lappa L., var. Herkules. by Kardosová A, Ebringerová A, Alföldi J, Nosál'ová G, Franová S, Hríbalová V.(PubMed)
(3) Chronic cough in young adults in relation to smoking habits, childhood environment and chest illness by Kiernan KE, Colley JR, Douglas JW, Reid DD. (PubMed)

Saturday, 12 January 2019

Celery, the Potential Functional Food For the Prevention and Treatment of Diseases Associated with Oxidative Stress

By Kyle J. Norton

Scientists may have found a functional food for the prevention and treatment of the diseases associated with oxidative stress, according to the studies.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

Oxidative stress is a condition caused by long-term overexpression of free radicals in the body.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host.

Free radicals are unstable atoms with an unpaired electron in the outer ring. In order for them to become stable, they must either donate or steal an electron from the stable atoms. These actions lead to a chain reaction which can not be stopped until all free radicals outer ring electron is paired or inhibited by antioxidants.

Antioxidants are stable atoms which inhibited oxidation. there are 2 types of antioxidant in our body. The antioxidant enzymes which are produced by the host body and dietary antioxidants which is come from food intake.

Epidemiological studies strongly suggested that oxidative stress not only can cause damage to the proteins, lipid, and cells but also can alternate the cell DNA, leading to a number of chronic ailments, including cancers.

Diseases associated with oxidative stress are atherosclerosis, cancer, inflammatory joint disease, asthma, diabetes, senile dementia, and degenerative eye disease.

We can not stop free radical from entering into our body as they present in nature in different forms, including fried foods, alcohol, tobacco smoke, pesticides, air pollutants, and many more, however, we can neutralize them by eating a healthy diet with more antioxidants and less free radical products.

With an aim to find a natural ingredient or whole food for the prevention and treatment of oxidative stress, researchers investigated the effects of flavonoid extracts from celery on oxidative stress induced by dichlorvos (DIC) in male Wistar rats maintained on a normal diet.

The rats selected to the study were given DIC through intragastric administration by the dose of 7.2 mg/kg·body weight (BW)/day and additionally added 5% flavonoid extracts to the diet for 4 weeks continuously.

Before injecting flavonoid extract rats treated with DIC demonstrated a significant decrease of antioxidant enzymes produced by the host and increased oxidative stress markers.

Application of 5% flavonoid extracts increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST) and decreased the content of malondialdehyde (MDA) in livers of rats.

The activities of SOD, GST, and CAT in the DIC-treated group declined significantly when compared with the flavonoid extracts group and the DIC + flavonoid extracts group, respectively.

These results suggested that the protective role of flavonoids in minimizing oxidative stress caused by the harmful effects of DIC during the exposure.

Futhermore, in order to understand the protective role of celery extract, researchers launched an investigation to assess the celery leaves and roots in the ether, chloroform, ethyl acetate, n-butanol and water against oxidative stress.

In vitro, crude methanol extracts displayed potential scavengers of free OH* and DPPH* radicals, as well as inhibitors of liposomal peroxidation (LPx).

In vivo experiments, the extract also improved the antioxidant systems (activities of GSHPx, GSHR, Px, CAT, XOD, GSH content and intensity of LPx) in the liver.

The extracts bioactive compound the n-butanol showed the highest protective effect.

Dr. Popović M, the lead author said, "The differences observed in the action of particular extracts are probably due to the different contents of flavonoids and some other antioxidant compound".

Taken altogether, celery with abundant bioactive compounds may be considered a functional food for the prevention and treatment of diseases associated with the oxidative stress.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References

(1) Antioxidant and antiproliferative activities of common vegetables by Chu YF1, Sun J, Wu X, Liu RH. (PubMed)
(2) Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats.
Cao J1, Zhang X, Wang Q, Jia L, Zhang Y, Zhao X.(PubMed)
(3) Effect of celery (Apium graveolens) extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride by Popović M1, Kaurinović B, Trivić S, Mimica-Dukić N, Bursać M.(PubMed)
(4) Essential oil composition and antiradical activity of the oil of Iraq plants by Kiralan M1, Bayrak A, Abdulaziz OF, Ozbucak T.(PubMed)

Ginger, The Potential Anti Breast Cancer Functional Remedy, Studies Found

By Kyle J. Norton

Ginger may be the next natural whole food for the prevention and treatment of breast cancer, without inducing any side effects, some scientists said.

Breast cancer is a medical condition caused by cell growth disorderly and irregularly in the breast tissue.

Most cases of primary breast cancer start either in the cell on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the early stage, some women may experience, lump (mass) in the breast or in the armpit (lymph nodes), nipple abnormal discharge, inverted or retracted nipple, scaly or pitted skin on the nipple and persistent tenderness of the breast.

Invasive primary breast cancer at the advanced stage, after penetrating deeper in the breast tissue, the malignant cells can travel a distance away to infect other healthy tissue and organs.

Metastatic breast cancer (also called stage IV) are mostly found in the liver, brain, bones, or lungs.

According to the World Health Organization, breast cancer is the most common cancer in women both in the developed and less developed world, causing the worldwide death of over 508 000 women in 2011.

In the US, In 2018, over 260,000 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with over 63,000 new cases of non-invasive (in situ) breast cancer.

The risk of an American woman diagnosed with breast cancer during her lifetime is 12.4%.

Early diagnosed with breast cancer can increase the chance of survival. The 5 years survival rate of women diagnosed with stage 0 and I is 100%.

The exact causes of breast cancer are unknown. However, researchers do know that genetic preposition, obesity, unhealthy diet and lifestyle such as smoking, excessive alcohol consumption are some most prevalent risk factors of breast cancer.

Some researchers also suggested that long-term use of oral contraceptive and psychological stress and anxiety are associated with the increased risk of the disease.

Dr, Kathleen E. Malone, in the concerns of oral contraceptive use in risk of breast cancer said, " In recent years, a large number of studies have focused on breast cancer risk in women under age 45. Meirik and colleagues (1986) published the first report suggesting a dose-response relationship with duration of oral contraceptive use among young women: for use of 8 to 11 years, an RR of 1.4 was found; for 12 or more years of use, a 2.2-fold excess risk of breast cancer was found. Paul and colleagues (1986) reported an RR of 4.6 for use of 10 or more years among women aged 25–34. McPherson and coworkers (1987) found an increased RR of 1.8 for use exceeding 11 years among a group of British women through age 45".

These results clearly indicated the risk of breast cancer is increased linearly to the years of the use of oral contraceptive.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a nonexpensive natural ingredient and whole food for the prevention and treatment of breast cancer, researchers examine the anti-breast cancer effects of kombucha tea with or without ginger.

Selected BALB/c mice were given 2 types of kombucha tea with or without ginger before and after tumor challenge.

Administration of kombucha ginger tea demonstrated a significantly decreased catalase activity in the decomposition of hydrogen peroxide to water and oxygen and GSH and MDA level in tumor homogenate compared to kombucha without ginger.

Furthermore, mice group treated the combined products significant decrease in SOD activity and an increase in MDA quantity in the tumors.

Dr. Salafzoon S, the lead scientists said, " The consumption of kombucha prepared from ginger could exert minor antioxidant impacts by balancing multi-antioxidant factors in different tissues in the breast cancer models".

Moreover, in the investigation of [10]-gingerol anti-breast cancer activity, using human MDA-MB-231TNBC cells, compared to non-tumor MCF-10A breast cells, researchers suggested [10]-gingerol was able to inhibit cell adhesion, migration, invasion, and apoptosis more effectively in TNBC cells, without causing harm to the nearby healthy cells.

Additional analysis also found, [10] gingerol anti-breast cancer properties are associated with the apoptotic and genotoxic activity, through stimulating the free radicals overexpression in the induction of cancer cells cytotoxicity.

After taking into account co and confounders, the team said, " ...results found here are complementary to previous studies of group and others and demonstrate that additional mechanisms, besides apoptotic cell death, is used by [10]-gingerol to accomplish its antitumor and antimetastatic effects".

Taken altogether, ginger with abundant bioactive compounds may be considered a functional food for the prevention and combined with other primary therapy for the treatment of breast cancer with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Evaluation of the antioxidant impact of ginger-based kombucha on the murine breast cancer model by Salafzoon S1, Mahmoodzadeh Hosseini H2, Halabian R. (PubMed)
(2) [10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDA-MB-231 Breast Tumor Cells by Fuzer AM1, Martin ACBM1, Becceneri AB1, da Silva JA2, Vieira PC3, Cominetti MR. (PubMed)
(3) [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo by Martin ACBM#1, Fuzer AM#1, Becceneri AB1, da Silva JA2, Tomasin R1, Denoyer D3, Kim SH4, McIntyre KA5, Pearson HB6, Yeo B7, Nagpal A7, Ling X4, Selistre-de-Araújo HS8, Vieira PC2, Cominetti MR#1, Pouliot. (PubMed)
(4) A. Oral Contraceptives and Breast Cancer: A Review of the Epidemiological Evidence with an Emphasis on Younger Women by Kathleen E. Malone. (NCBI)

Honey, the Anti Varicella Zoster Virus (VZV) Functional Food, According to Studies

By Kyle J. Norton

Honey may have a profound effect in reducing the risk and treatment of varicella-zoster virus (VZV), some scientists suggested.

Varicella-zoster virus is a member of the herpesviruses that cause chickenpox in children, teens, and young adults, and shingles and recurrent shingles in adults.

The disease has been found worldwide and is highly contagious.

Chickenpox usually caused by exposure either through direct contact with a skin lesion or airborne spread from respiratory droplets from infected patients.

In the initial stage of infection, the symptoms usually resolve within 7 to 10 days.

After initial infection, VZV establishes lifelong latency in cranial nerve and dorsal root ganglia and can reactivate years to decades later.

Reactivation of the dormant virus results in the later years can lead to painful dermatomal rash followed by pain in the distribution of the rash.

In some cases, the diseases can cause infrequently complications of hepatitis, pancreatitis, pneumonitis, and encephalitis and be life-threatening.

However, some adults and children are more likely to develop such complications from primary infection

According to the statistic, in the US, more than 90% of adults acquired the disease in childhood, due to vaccinated with the live virus vaccine.

Dr. Maria A. Nagel and colleagues in the summary of the disease associated with the Varicella zoster virus (VZV), said, "With advancing age or immunosuppression, cell-mediated immunity to VZV declines and virus reactivates to cause zoster (shingles), which can occur anywhere on the body"

" Skin lesions resolve within 1-2 weeks, while complete cessation of pain usually takes 4-6 weeks" and "Zoster can be followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresis, meningoencephalitis, cerebellitis, myelopathy, multiple ocular disorders and vasculopathy that can mimic giant cell arteritis. All of the neurological and ocular disorders listed above may also develop without rash".

These results clearly suggested that the elderly due to the increase in age and weaken the immune system, are considered to be the risk group for the development of serious and even life-threatening complications.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient ]or whole food for the prevention and treatment of varicella-zoster virus (VZV) infection, researchers at the University of Colorado Denver evaluated the anti-viral effect of honey on varicella zoster virus in vitro.

The tested VZV was obtained from a zoster vesicle.

Manuka and clover kinds of honey were used at concentrations ranging from 0-6% wt/vol in the study.

During the experiment, various concentrations of manuka and clover honey were added to the tissue culture medium of VZV-infected human malignant melanoma (MeWo) cell.

According to the assay, both types of honey demonstrate significantly antiviral activity against varicella-zoster virus with an approximate EC50 = 4.5 % (wt/vol).

At the final report, researchers suggested honey can be considered an anti-varicella-zoster virus agent, because it is an inexpensive product which can be bought at any grocery store and convenient for skin application.

Dr. Shahzad A, said, "honey may be an excellent remedy to treat zoster rash in developing countries where antiviral drugs are expensive or not easily available".

Taken altogether, honey may be used as a topical function food for the prevention of varicella zoster virus (VZV) infection and combined with primary therapy for the treatment of chickenpox in children and shingles and recurrent shingles in adults with no side effects.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of honey anti chickenpox and anti shingles possibilities.

Sources
(1) In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles by Shahzad A1, Cohrs RJ. (PubMed)
(2) Varicella Zoster Complications by Maria A. Nagel, MDa and Don Gilden, MD. (PubMed)

Friday, 11 January 2019

Phytochemical Indole-3-carbinol (I3C), the Potent Anti Cervical Cancer Plant Base Agent

By Kyle J. Norton

Indole-3-carbinol may be the next pharmaceutical ingredient for the prevention and treatment of cervical cancer with no side effects, some studies suggested.

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

Researchers do not know what causes cervical cancer. Neither they can explain that women with the same health condition, family history, some are susceptible to the disease while others do not.

Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. At this stage, most women with cervical cancer do not experience any symptoms.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients.

The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites.

Epidemiological also suggested that HPV infection, sexual activity, smoking, giving birth many times. Infection with the human immunodeficiency virus (HIV, history of sexually transmitted infections (STIs) and long-term use of oral contraceptives are some prevalent risk factors of cervical cancer.

However, most women with some of the risk factors have never developed cervical cancer.

According to the statistic, the 5-year survival rate for women with invasive cervical cancer is 92%. and approximately, 46% of women with cervical cancer are diagnosed at an early stage.

With an aim to find a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers investigated the anticancer effect of I3C and its major acid-catalyzed condensation product diindolylmethane (DIM), against the human cervical cancer cell lines.

In vitro, both I3C and DIM caused accumulation of DNA strand breaks and induction of apoptosis in three cervical cancer cell lines.

In C33A cervical cancer cells, DIM was more potent than I3C and faster acting.

I3C reduced the expression of a protein associated with the cancer cell proliferation and survival in a time- and dose-dependent manner.

Futhermore, I3C also promoted the protein associated with the programming cancer cell death.

Moreover, Mice that express transgenes for human papillomavirus type 16 under a keratin 14 promoter (K14-HPV16 mice) induced cervical cancer by given 17beta-estradiol chronically, researchers found that indole-3-carbinol (I3C) administered at physiological doses, would prevent cervical-vaginal cancer promoted by high doses of estrogen.

Compared to mice fed a control diet with those fed a diet supplemented with 2000 ppm I3C, researchers surprisingly discovered that only 2 mice of 24 in the group fed the I3C supplemented diet developed cervical cancer. I3C also reduced dysplasia in the nontransgenic mice.

Dr. Jin L after taking into account co and confounders said, " I3C is a useful preventive for cervical-vaginal cancer and, possibly, other cancers with a papillomavirus component."

Also, in a cervical cancer cell line, application of 13C exhibited the genes associated with cancer suppression through a number of mechanisms, including cancer cell adhesion, spreading, and invasion.

These results reconfirmed that the diminished PTEN expression during the progression from low-grade to high-grade cervical dysplasia in humans and in a mouse model for cervical cancer.

Taken altogether, Indole-3-carbinol (I3C) may be used for the prevention and treatment of cervical cancer with no side effects, pending to large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(4) Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium by Chen DZ1, Qi M, Auborn KJ, Carter TH. (PubMed)
(5) Indole-3-carbinol prevents cervical cancer in human papillomavirus type 16 (HPV16) transgenic mice by Jin L1, Qi M, Chen DZ, Anderson A, Yang GY, Arbeit JM, Auborn KJ. (PubMed)
(6) Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo by Qi M1, Anderson AE, Chen DZ, Sun S, Auborn KJ.(PubMed)