Celery, the Potential Functional Food For the Prevention and Treatment of Diseases Associated with Oxidative Stress

By Kyle J. Norton

Scientists may have found a functional food for the prevention and treatment of the diseases associated with oxidative stress, according to the studies.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

Oxidative stress is a condition caused by long-term overexpression of free radicals in the body.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host.

Free radicals are unstable atoms with an unpaired electron in the outer ring. In order for them to become stable, they must either donate or steal an electron from the stable atoms. These actions lead to a chain reaction which can not be stopped until all free radicals outer ring electron is paired or inhibited by antioxidants.

Antioxidants are stable atoms which inhibited oxidation. there are 2 types of antioxidant in our body. The antioxidant enzymes which are produced by the host body and dietary antioxidants which is come from food intake.

Epidemiological studies strongly suggested that oxidative stress not only can cause damage to the proteins, lipid, and cells but also can alternate the cell DNA, leading to a number of chronic ailments, including cancers.

Diseases associated with oxidative stress are atherosclerosis, cancer, inflammatory joint disease, asthma, diabetes, senile dementia, and degenerative eye disease.

We can not stop free radical from entering into our body as they present in nature in different forms, including fried foods, alcohol, tobacco smoke, pesticides, air pollutants, and many more, however, we can neutralize them by eating a healthy diet with more antioxidants and less free radical products.

With an aim to find a natural ingredient or whole food for the prevention and treatment of oxidative stress, researchers investigated the effects of flavonoid extracts from celery on oxidative stress induced by dichlorvos (DIC) in male Wistar rats maintained on a normal diet.

The rats selected to the study were given DIC through intragastric administration by the dose of 7.2 mg/kg·body weight (BW)/day and additionally added 5% flavonoid extracts to the diet for 4 weeks continuously.

Before injecting flavonoid extract rats treated with DIC demonstrated a significant decrease of antioxidant enzymes produced by the host and increased oxidative stress markers.

Application of 5% flavonoid extracts increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST) and decreased the content of malondialdehyde (MDA) in livers of rats.

The activities of SOD, GST, and CAT in the DIC-treated group declined significantly when compared with the flavonoid extracts group and the DIC + flavonoid extracts group, respectively. 

These results suggested that the protective role of flavonoids in minimizing oxidative stress caused by the harmful effects of DIC during the exposure.

Futhermore, in order to understand the protective role of celery extract, researchers launched an investigation to assess the celery leaves and roots in the ether, chloroform, ethyl acetate, n-butanol and water against oxidative stress.

In vitro, crude methanol extracts displayed potential scavengers of free OH* and DPPH* radicals, as well as inhibitors of liposomal peroxidation (LPx).

In vivo experiments, the extract also improved the antioxidant systems (activities of GSHPx, GSHR, Px, CAT, XOD, GSH content and intensity of LPx) in the liver.

The extracts bioactive compound the n-butanol showed the highest protective effect.

Dr. Popović M, the lead author said, "The differences observed in the action of particular extracts are probably due to the different contents of flavonoids and some other antioxidant compound".

Taken altogether, celery with abundant bioactive compounds may be considered a functional food for the prevention and treatment of diseases associated with the oxidative stress.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References

(1) Antioxidant and antiproliferative activities of common vegetables by Chu YF1, Sun J, Wu X, Liu RH. (PubMed)
(2) Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats.
Cao J1, Zhang X, Wang Q, Jia L, Zhang Y, Zhao X.(PubMed)
(3) Effect of celery (Apium graveolens) extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride by Popović M1, Kaurinović B, Trivić S, Mimica-Dukić N, Bursać M.(PubMed)
(4) Essential oil composition and antiradical activity of the oil of Iraq plants by Kiralan M1, Bayrak A, Abdulaziz OF, Ozbucak T.(PubMed)

Ginger, The Potential Anti Breast Cancer Functional Remedy, Studies Found

By Kyle J. Norton

Ginger may be the next natural whole food for the prevention and treatment of breast cancer, without inducing any side effects, some scientists said.

Breast cancer is a medical condition caused by cell growth disorderly and irregularly in the breast tissue.

Most cases of primary breast cancer start either in the cell on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the early stage, some women may experience,  lump (mass) in the breast or in the armpit (lymph nodes), nipple abnormal discharge, inverted or retracted nipple, scaly or pitted skin on the nipple and persistent tenderness of the breast.

Invasive primary breast cancer at the advanced stage, after penetrating deeper in the breast tissue, the malignant cells can travel a distance away to infect other healthy tissue and organs.

Metastatic breast cancer (also called stage IV) are mostly found in the liver, brain, bones, or lungs.

According to the World Health Organization, breast cancer is the most common cancer in women both in the developed and less developed world, causing the worldwide death of over 508 000 women in 2011.

In the US, In 2018, over 260,000 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with over 63,000 new cases of non-invasive (in situ) breast cancer.

The risk of an American woman diagnosed with breast cancer during her lifetime is 12.4%. 

Early diagnosed with breast cancer can increase the chance of survival. The 5 years survival rate of women diagnosed with stage 0 and I is 100%.

The exact causes of breast cancer are unknown. However, researchers do know that genetic preposition, obesity, unhealthy diet and lifestyle such as smoking, excessive alcohol consumption are some most prevalent risk factors of breast cancer.

Some researchers also suggested that long-term use of oral contraceptive and psychological stress and anxiety are associated with the increased risk of the disease.

Dr, Kathleen E. Malone, in the concerns of oral contraceptive use in risk of breast cancer said, " In recent years, a large number of studies have focused on breast cancer risk in women under age 45. Meirik and colleagues (1986) published the first report suggesting a dose-response relationship with duration of oral contraceptive use among young women: for use of 8 to 11 years, an RR of 1.4 was found; for 12 or more years of use, a 2.2-fold excess risk of breast cancer was found. Paul and colleagues (1986) reported an RR of 4.6 for use of 10 or more years among women aged 25–34. McPherson and coworkers (1987) found an increased RR of 1.8 for use exceeding 11 years among a group of British women through age 45".

These results clearly indicated the risk of breast cancer is increased linearly to the years of the use of oral contraceptive.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a nonexpensive natural ingredient and whole food for the prevention and treatment of breast cancer, researchers examine the anti-breast cancer effects of kombucha tea with or without ginger.

Selected BALB/c mice were given 2 types of kombucha tea with or without ginger before and after tumor challenge.

Administration of kombucha ginger tea demonstrated a significantly decreased catalase activity in the decomposition of hydrogen peroxide to water and oxygen and GSH and MDA level in tumor homogenate compared to kombucha without ginger.

Furthermore, mice group treated the combined products significant decrease in SOD activity and an increase in MDA quantity in the tumors.

Dr. Salafzoon S, the lead scientists said, " The consumption of kombucha prepared from ginger could exert minor antioxidant impacts by balancing multi-antioxidant factors in different tissues in the breast cancer models".

Moreover, in the investigation of [10]-gingerol anti-breast cancer activity, using human MDA-MB-231TNBC cells, compared to non-tumor MCF-10A breast cells, researchers suggested [10]-gingerol was able to inhibit cell adhesion, migration, invasion, and apoptosis more effectively in TNBC cells, without causing harm to the nearby healthy cells.

Additional analysis also found, [10] gingerol anti-breast cancer properties are associated with the apoptotic and genotoxic activity, through stimulating the free radicals overexpression in the induction of cancer cells cytotoxicity.

After taking into account co and confounders, the team said, " ...results found here are complementary to previous studies of group and others and demonstrate that additional mechanisms, besides apoptotic cell death, is used by [10]-gingerol to accomplish its antitumor and antimetastatic effects".

Taken altogether, ginger with abundant bioactive compounds may be considered a functional food for the prevention and combined with other primary therapy for the treatment of breast cancer with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Evaluation of the antioxidant impact of ginger-based kombucha on the murine breast cancer model by Salafzoon S1, Mahmoodzadeh Hosseini H2, Halabian R. (PubMed)
(2) [10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDA-MB-231 Breast Tumor Cells by Fuzer AM1, Martin ACBM1, Becceneri AB1, da Silva JA2, Vieira PC3, Cominetti MR. (PubMed)
(3) [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo by Martin ACBM#1, Fuzer AM#1, Becceneri AB1, da Silva JA2, Tomasin R1, Denoyer D3, Kim SH4, McIntyre KA5, Pearson HB6, Yeo B7, Nagpal A7, Ling X4, Selistre-de-Araújo HS8, Vieira PC2, Cominetti MR#1, Pouliot. (PubMed)
(4) A. Oral Contraceptives and Breast Cancer: A Review of the Epidemiological Evidence with an Emphasis on Younger Women by Kathleen E. Malone. (NCBI)

Honey, the Anti Varicella Zoster Virus (VZV) Functional Food, According to Studies

By Kyle J. Norton

Honey may have a profound effect in reducing the risk and treatment of varicella-zoster virus (VZV), some scientists suggested.

Varicella-zoster virus is a member of the herpesviruses that cause chickenpox in children, teens, and young adults, and shingles and recurrent shingles in adults.

The disease has been found worldwide and is highly contagious.

Chickenpox usually caused by exposure either through direct contact with a skin lesion or airborne spread from respiratory droplets from infected patients.

In the initial stage of infection, the symptoms usually resolve within 7 to 10 days.

After initial infection, VZV establishes lifelong latency in cranial nerve and dorsal root ganglia and can reactivate years to decades later.

Reactivation of the dormant virus results in the later years can lead to painful dermatomal rash followed by pain in the distribution of the rash. 

In some cases, the diseases can cause infrequently complications of hepatitis, pancreatitis, pneumonitis, and encephalitis and be life-threatening.

However, some adults and children are more likely to develop such complications from primary infection

According to the statistic, in the US, more than 90% of adults acquired the disease in childhood, due to vaccinated with the live virus vaccine.

Dr. Maria A. Nagel and colleagues in the summary of the disease associated with the Varicella zoster virus (VZV), said, "With advancing age or immunosuppression, cell-mediated immunity to VZV declines and virus reactivates to cause zoster (shingles), which can occur anywhere on the body"

" Skin lesions resolve within 1-2 weeks, while complete cessation of pain usually takes 4-6 weeks" and "Zoster can be followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresis, meningoencephalitis, cerebellitis, myelopathy, multiple ocular disorders and vasculopathy that can mimic giant cell arteritis. All of the neurological and ocular disorders listed above may also develop without rash".

These results clearly suggested that the elderly due to the increase in age and weaken the immune system, are considered to be the risk group for the development of serious and even life-threatening complications.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient ]or whole food for the prevention and treatment of varicella-zoster virus (VZV) infection, researchers at the University of Colorado Denver evaluated the anti-viral effect of honey on varicella zoster virus in vitro.

The tested VZV  was obtained from a zoster vesicle.

Manuka and clover kinds of honey were used at concentrations ranging from 0-6% wt/vol in the study.

During the experiment, various concentrations of manuka and clover honey were added to the tissue culture medium of VZV-infected human malignant melanoma (MeWo) cell.

According to the assay, both types of honey demonstrate significantly antiviral activity against varicella-zoster virus with an approximate EC50 = 4.5 % (wt/vol).

At the final report, researchers suggested honey can be considered an anti-varicella-zoster virus agent, because it is an inexpensive product which can be bought at any grocery store and convenient for skin application.

Dr. Shahzad A, said, "honey may be an excellent remedy to treat zoster rash in developing countries where antiviral drugs are expensive or not easily available".

Taken altogether, honey may be used as a topical function food for the prevention of varicella zoster virus (VZV) infection and combined with primary therapy for the treatment of chickenpox in children and shingles and recurrent shingles in adults with no side effects.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of honey anti chickenpox and anti shingles possibilities.

.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles by Shahzad A1, Cohrs RJ. (PubMed)
(2) Varicella Zoster Complications by Maria A. Nagel, MDa and Don Gilden, MD. (PubMed)

Phytochemical Indole-3-carbinol (I3C), the Potent Anti Cervical Cancer Plant Base Agent

By Kyle J. Norton

Indole-3-carbinol may be the next pharmaceutical ingredient for the prevention and treatment of cervical cancer with no side effects, some studies suggested.

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

Researchers do not know what causes cervical cancer. Neither they can explain that women with the same health condition, family history, some are susceptible to the disease while others do not.

Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. At this stage, most women with cervical cancer do not experience any symptoms.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients.

The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites.

Epidemiological also suggested that HPV infection, sexual activity, smoking, giving birth many times. Infection with the human immunodeficiency virus (HIV, history of sexually transmitted infections (STIs) and long-term use of oral contraceptives are some prevalent risk factors of cervical cancer.

However, most women with some of the risk factors have never developed cervical cancer.

According to the statistic, the 5-year survival rate for women with invasive cervical cancer is 92%. and approximately, 46% of women with cervical cancer are diagnosed at an early stage.

With an aim to find a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers investigated the anticancer effect of I3C and its major acid-catalyzed condensation product diindolylmethane (DIM), against the human cervical cancer cell lines.

In vitro, both I3C and DIM caused accumulation of DNA strand breaks and induction of apoptosis in three cervical cancer cell lines.

In C33A cervical cancer cells, DIM was more potent than I3C  and faster acting.

I3C reduced the expression of a protein associated with the cancer cell proliferation and survival in a time- and dose-dependent manner. 

Futhermore, I3C  also promoted the protein associated with the programming cancer cell death.

Moreover, Mice that express transgenes for human papillomavirus type 16 under a keratin 14 promoter (K14-HPV16 mice) induced cervical cancer by given 17beta-estradiol chronically, researchers found that indole-3-carbinol (I3C) administered at physiological doses, would prevent cervical-vaginal cancer promoted by high doses of estrogen.

Compared to mice fed a control diet with those fed a diet supplemented with 2000 ppm I3C, researchers surprisingly discovered that only 2 mice of 24 in the group fed the I3C supplemented diet developed cervical cancer. I3C also reduced dysplasia in the nontransgenic mice.

Dr. Jin L after taking into account co and confounders said, " I3C is a useful preventive for cervical-vaginal cancer and, possibly, other cancers with a papillomavirus component."

Also, in a cervical cancer cell line, application of 13C exhibited the genes associated with cancer suppression through a number of mechanisms, including cancer cell adhesion, spreading, and invasion.

These results reconfirmed that the diminished PTEN expression during the progression from low-grade to high-grade cervical dysplasia in humans and in a mouse model for cervical cancer.

Taken altogether, Indole-3-carbinol (I3C) may be used for the prevention and treatment of cervical cancer with no side effects, pending to large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(4) Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium by Chen DZ1, Qi M, Auborn KJ, Carter TH. (PubMed)
(5) Indole-3-carbinol prevents cervical cancer in human papillomavirus type 16 (HPV16) transgenic mice by Jin L1, Qi M, Chen DZ, Anderson A, Yang GY, Arbeit JM, Auborn KJ. (PubMed)
(6) Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo by Qi M1, Anderson AE, Chen DZ, Sun S, Auborn KJ.(PubMed)

Anacardic acids, the Anti Pituitary Adenomas Bioactive Ingredient

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of pituitary adenomas with no side effects, according to studies.

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

Pituitary adenomas are noncancerous tumors occurred in the pituitary gland.

A pituitary tumor has a negative and strong implication of the production of the thyroid-stimulating hormone, leading to a rare case of hyperthyroidism which normally induces the unintentional weight loss.

Most cases of the pituitary adenomas start in the cell of the inner lining of the tissue of the pituitary gland, due to the alternation of DNA. The tumor is well contained in the gland with no tendency of spreading.

At the early stage, patients with benign tumor do not experience any symptoms. However, when the tumor is growing larger, it may suppress the healthy tissue in the gland or nearby nerve cells, leading to symptoms of a headache, vision loss, and severe pain.

Epidemiological studies suggested that depending on the stage of the pituitary tumor, patients can experience hormone overproduction and hormone deficiency, leading to certain hormonal related diseases.

Depending on the size of the tumor and its effect on the patient's health, surgery may be the only option, if the tumor is pressing on the optic nerves or overproducing certain hormones.

In the concern of morbidity and complication of therapy in patients with pituitary adenomas, researchers examined the effect of Anacardic acids, a natural histone acetyltransferase inhibitor, on pituitary adenoma cells.

Epidemiological studies suggested that the progression of the benign pituitary tumor, if not treated, is a prevalent risk factor of the onset of malignant tumor pathogenesis.

Injection of anacardic acid exerted a significant anti antiproliferative and cytotoxic effect on pituitary adenoma cells.

According to the flow cytometry and Western blotting assays, anacardic acid inhibition of the tested cell line was associated with an increase the functions of the protein involved in a number of cellular processes in programming cell death and through cell cycle arrest on the G1 phase.

The marker used to detect cancer cell apoptosis, Annexin A5 (or annexin V), a cellular protein in the annexin group also increased after injecting the cancer cell with Anacardic acids. 

In vitro and in vivo researchers found that administration of a pan-caspase inhibitor that irreversibly inhibits enzymatic function and effective in blocking apoptosis in a variety of cell types under normal condition has failed to reverse anacardic acid-induced cell death. 

These results suggested that the bioactive induced cancer cell apoptosis through a possible nonclassical mechanism.

Furthermore, Anacardic acid the anti-cancer effect also suppressed the function of the survivin protein functions to exhibit negative regulation of apoptosis or programmed cell death and X-linked inhibitor of apoptosis protein (XIAP) associated with the anti-apoptotic function.

More importantly, the bioactive compound was found to deactivate the antiapoptotic proteins associated with cellular survival and radioresistance and radiosensitized pituitary adenoma cells.

The findings indicated that the chemical compound inhibited the onset and progression of pituitary adenomas through promoting cell cycle arrest, cancer apoptosis, programming cell death through some known and unknown mechanisms.

Taken all together, Anacardic acids may be used for the prevention and treatment of pituitary adenomas with no side effects, pending to the result of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells by Sukumari-Ramesh S, Singh N, Jensen MA, Dhandapani KM, Vender JR.(PubMed)

Phytochemical Allicin, the Natural Anti Hyper Cholesterol Bioactive Compound

By Kyle J. Norton

Allicin, the bioactive ingredient isolated from garlic may have a profound effect on the prevention and treatment of high blood cholesterol with no side effects, according to studies.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the bloodstream. In other words, the levels of low-density lipoprotein (LDL) are high compared to the high-density lipoprotein (LDL) in the blood.

The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).

Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.

Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.

Some researchers suggested that Diet high in trans fats, saturated fat, sugar, smoking, medical conditions such as diabetes or high blood pressure are associated with the increased risk of high blood cholesterol.

Epidemiological studies indicated a healthy diet that contains a high amount of fruits and vegetables and whole grain have a positive on blood cholesterol. In other words, hyperlipidemia can be prevented by a healthy diet.

Dr. Heather D. Mann, in the discussion of a healthy in the risk of hyperlipidemia, said, " Dietary modification is effective in achieving and maintaining improved serum lipid levels".

The finding clearly suggested that if you follow the diet with a high in saturated and trans fat, red meat and processed food and low in fruits and vegetables and whole grain, you are at the increased risk of high blood cholesterol.

High blood cholesterol does not cause symptoms, the American Heart Association recommends that all adults have their cholesterol checked every 4 to 6 years, starting at age 20, the age when cholesterol levels start to go up.

In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not in reducing blood cholesterol, triglycerides, and glucose levels, as well as lowering the hepatic cholesterol storage, but also decreasing appetite daily.

 Other in the study of the same but with rat fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats. These result showed that allicin may be considered as a potent agent in treating hyper cholesterol in the future.

On finding a natural ingredient for the prevention and treatment of high blood cholesterol, a widespread syndrome found in the Western world, researchers investigated the cholesterol-lowering properties of allicin, a bioactive compound isolated from garlic.

Hypercholesterolemia in male ICR mice selected for the study was given allicin, with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks.

After week 12, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively.

Allicin fed group also showed the most decrease in daily food consumption compared to control.

Furthermore, allicin showed a strong effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering hepatic cholesterol storage.

These results suggested that allicin is a potential value in a cholesterol-lowering candidate, and may be used for the protection against the onset of atherosclerosis.

Moreover, in the evaluation of the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, triglyceride, glucose, protein, and systolic blood pressure in rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks, and control rats were fed a normal diet researchers found that

* Rats fed with a high cholesterol diet mixed with garlic powder demonstrate a significant reduction in their serum cholesterol levels compared to the control group.

* Serum triglyceride levels were also significantly lowered by garlic powder when compared to control and high cholesterol diet group rats.

* The blood pressure of the high cholesterol diet animals was significantly higher compared to the animals receiving the control diet.

* The blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to the high cholesterol and control diet group.

Once again, garlic with high amounts of allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats.

Taken altogether, allicin on the garlic may be used daily for the prevention or treatment of high blood cholesterol with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
(3) Diet Modification for Hyperlipidemia. Individual approach to diet planning and education by Heather D. Mann and Pamela Piotrowski. (PMC)

Avocado-Soybean Unsaponifiables (ASUs), A Natural Treatment of Osteoarthritis, with No side Effects, Studies Showed

By Kyle J. Norton

Avocado may be considered a functional food for the prevention and treatment of osteoarthritis, some scientists suggested.

Avocado is commercially valuable fruit cultivated in tropical climates throughout the world.

The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.

According to the statistic, osteoarthritis (OA) is the most common joint disorder in the US, affecting over 10% men and 13% in women aged 60 years or older. The disease can also affect the younger population, after a traumatic injury.

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Epidemiological studies suggested that symptoms progress slowly and contribute to workplace disability and reduced quality of life.

Dr. Hofmann S, the lead scientist in the team of arthritis in the examine the mechanical causes of osteoarthritis in young adults suggested that that certain conditions such as femoroacetabular impingement (a condition in which extra bone grows along one or both of the bones that form the hip joint) are a very common cause of secondary osteoarthritis (OA) in the young adults" and "

It is an important co-factor in the better recognized pre-arthritic deformities such as residual hip dysplasia (RHD), Perthes disease and slipped capital femoral epiphysis (SCFE)".

These results clearly indicated genetic mutation and mechanical deformity are major causes of osteoarthritis in the younger adult besides athletic injury.

Some scientists proposed that the development of femoroacetabular impingement may be a result of a repetitive injury to the proximal femoral physis occurs during a critical period of development.

With an aim to find a natural ingredient for the prevention and treatment of osteoarthritis, a disease associated with the progressive denegation of joints, researchers at the Universities of Exeter and Plymouth assessed the anti-OA of the compounds Avocado/soybean unsaponifiables (ASU) which have shown some promise for OA.

By searching the database of medical literature, researchers found 4 randomized, placebo-controlled, double-blind trials of ASU.satisified the guideline and criteria.

The doses per day in the 4 studies are in the range between 300 mg and with 600 mg.

3 out 4 studies suggest that ASU is effective for the symptomatic treatment of OA.

Furthermore, the Hôpital Léopold Bellan launched a follow-up study to investigate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients in the hip, included 163 patients, 102 men and 61 women (mean age 63.2 +/- 8.7 years).

Participants in the study are patients with regular painful primary OA of the hip (European League Against Rheumatism 1980 criteria) and a joint space still > or = 1 mm were selected entered a prospective, multicenter, randomized, parallel group, double-blind, placebo-controlled trial of 2 years duration. 

ASU treatment group showed a lesser joint space loss compared to the significantly greater loss in the placebo group.

The clinical parameters in the 2 groups did not differ significantly throughout the study.

These results indicated a significant effect of ASU against the progression of joint loss in OA patients.

Dr,. the lead scientists said, "SU significantly reduced the progression of joint space loss as compared with placebo in the subgroup of patients with advanced joint space narrowing".

Taken altogether, avocado-soybean unsaponifiables (ASUs) may have a profound effect in reducing the symptoms and progression of osteoarthritis.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review by Ernst E.(PubMed)
(2) Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(3) Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip by Lequesne M1, Maheu E, Cadet C, Dreiser RL. (PubMed)
(4) Mechanical causes of osteoarthritis in young adults by Hofmann S, Tschauner Ch, Graf R.(PubMed)
(5) The etiology of primary femoroacetabular impingement: genetics or acquired deformity? by Jonathan D. Packer and Marc R. Safran. (PMC)