Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 3 January 2019

Herbal Andrographis, the Potential Anti-inflammation and Infection Functional Remedy

By Kyle J. Norton

Scientists may have found a herbal plant for the treatment of inflammatory diseases with no side effects, according to the studies.

Inflammation is a natural reaction of the immune system self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage of the body through activating the protein associated with the production of pro-inflammatory cytokines.

The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.

The immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness and fever.

Chronic inflammation is a serious condition caused by the immune system adapt to the new change due to its inability to kill all the invasion within a set of times.

Some researchers in the observation of the history of immune evolution suggested that immune system also try to adapt to the new environment such as chronic inflammation if, for whatever reasons, it can not fill all invasive pathogens within 3 to weeks, leading to the development of several diseases and conditions, including some cancers and rheumatoid arthritis.

Furthermore, chronic inflammation can also be caused by the autoimmune disorder, which involves your immune system mistakenly attacking healthy tissue, long-term exposure to irritants, such as industrial chemicals or polluted air.

Dr. Anne M. Minihane, the lead scientist in the study "Low-grade inflammation, diet composition, and health: current research evidence and its translation" wrote, "An unresolved inflammatory response is likely to be involved from the early stages of disease development" and " The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation–health/disease associations".

And. " Such approaches are likely to provide a more discriminating means of quantifying inflammation–health/disease associations, and the ability of diet to positively modulate inflammation and provide the much-needed evidence to develop research portfolios that will inform new product development and associated health claims".

The results clearly suggested that adding certain amounts of anti-inflammatory foods into your diet may be the best way to prevent chronic inflammatory diseases.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

With an aim to reaffirm the traditional use of Andrographis paniculata for treatment of infection and inflammation, researchers examined the effects of Andrograpanin, one of the diterpene lactones in A. paniculata in vivo and in vitro.

Application of Andrograpanin inhibited the NO and other 3 pro-inflammatory cytokines in a range from 5-90 microM at a dose-dependent manner.

The efficacy of anti-inflammatory activity of Andrograpanin was associated with the reduction of the expression of iNOS, enzymes in catalyzing the production of NO and pro-inflammatory cytokines gene (proteins) expression.

Furthermore, the anti-inflammatory effects were contributed by inhibiting the protein (p38) and (mitogen-activated protein kinase (MAPKs)) which are responsive to stress stimuli, p38 and stress response.

Dr. Liu J, after taking into account co and confounders wrote, "andrograpanin might be useful as a potential anti-inflammatory leading compound for inflammatory drug development".

Additional analysis of other major compound isolated from herbal Andrographis, researchers looked into Human β-defensin-2 (hBD-2), an inducible antimicrobial peptide that plays an important role in innate immunity.

As a prediction, according to the PCR and Western blot assays, injection of Andro (1.0-10 µmol/L) exhibits the expression of hBD-2 in a dose-dependent manner.

However, under the expression of SB203580 (an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK)), MG-132 (an inhibitor of nuclear factor κB (NF-κB)), and an NF-κB activator inhibitor, but not by an inhibitor of ERK (PD98059) or by an inhibitor of JNK(SP600125), the effects of hBD-2 mRNA and protein expression in responsive to andro were attenuated.

These results clearly suggested andro exert its antimicrobial effects by exhibiting the expression of hBD-2 through regulating the functions of the innate immune response against stress and stimuli.

Taken altogether, herbal Andrographis processed high levels of bioactive compounds may be considered a functional remedy against inflammation and infection.

References
(2) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells BY He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD. (PubMed)
(3) Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells by Shao ZJ, Zheng XW, Feng T, Huang J, Chen J, Wu YY, Zhou LM, Tu WW, Li H.(PubMed).
(4) Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways by Liu J, Wang ZT, Ge BX.(PubMed)
(5) Low-grade inflammation, diet composition and health: current research evidence and its translation by Anne M. Minihane, 1 ,* Sophie Vinoy, 2 Wendy R. Russell, 3 Athanasia Baka, 4 Helen M. Roche,5 Kieran M. Tuohy, 6 Jessica L. Teeling, 7 Ellen E. Blaak, 8 Michael Fenech, 9 David Vauzour, 1Harry J. McArdle, 3 Bas H. A. Kremer, 10 Luc Sterkman, 11 Katerina Vafeiadou, 12Massimo Massi Benedetti, 13 Christine M. Williams, 14 and Philip C. Calder. (PMC)

Herbal Butterbur, the Potent Anti Somatoform Disorders Functional Remedy

By Kyle J. Norton

Scientists may have found a natural herbal medicine for the prevention and treatment of Somatoform disorders with no side effects, according to studies.

Somatoform disorders are a group of psychiatric disorders that trigger unexplained physical symptoms.

Researchers do not the exact cause of the disorders. However, genetic preposition and family history are the 2 most common risk factors associated with the onset of the condition.

Most common symptoms include persistent pain or fatigue, emotional distress and problems functioning.

The American Family Physician in the article Somatoform disorders suggested up to 50 percent of primary care patients present with physical symptoms that cannot be explained by a general medical condition. Some of these patients meet criteria for somatoform disorders.

Dr. Bener A, the lead scientist, in examining the gender effects on somatoform disorders in a sample size of 1689 patients, including 892 men and 797 women suggested
* The prevalence rate of somatoform disorders among the total screened sample was 23.9%.

* Housewives (43.5%) and men in administrative posts (37.9%) reported higher somatic symptoms compared to other professions.

* Prolonged depressive reaction was significantly higher in women compared to men.

* There was a significant gender difference in certain psychiatric diagnostic categories such as depressive episode, recurrent depressive disorder, dysthymia, and brief depressive reaction.

* Backache was the most commonly reported symptom in men, whereas a headache was more common in women.

These results clearly suggested being female is a risk factor of Somatoform disorders and symptoms of Somatoform disorders. Somatoform disorders affect the different aspects of the patient depending on gender.

Women with Somatoform disorders are more likely to experience psychological symptoms compared to male.

Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.

With an aim to find a natural formula for the treatment of Somatoform disorder with no side effects, researchers at the University Hospital Zurich examined the effects of mixed herbal drug combination with and without butterbur (Ze 185) on patients with somatoform disorders.

In a total of 182 patients randomized for a 3-arm trial (butterbur root, valerian root, passionflower herb, lemon balm leaf versus valerian root, passionflower herb, lemon balm leaf versus placebo) compared to a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders in a 2-week treatment in patients with somatization disorder (F45.0) and undifferentiated somatoform disorder (F45.1), researchers discovered the 4-combination was significantly superior to the 3-combination and placebo (4-combination > 3-combination > placebo) in all the primary and secondary parameters (PP-population).

The levels of anxiety and depression, according to the Anxiety (visual analog scale - VAS) and depression (Beck's Depression Inventory - BDI) are also decreased more in 4 combinations compared to others.

According to the Clinical Global Impression (CGI) rating scales, 4 combinations also showed reduced symptom severity and improved treatment response compared to 3 combinations.

The results are further reconfirmed by the ITT population analysis.

Where (ITT) analysis is a treatment in which patients enrolled and randomly allocated to treatment are included in the analysis and are analyzed in the groups to which they were randomized.

All tested subject expressed no serious adverse effects during the course of experiments.

These results suggested the herbal preparation (Ze185) may be an efficacious and safe short-term treatment in patients with somatoform disorders.

Taken altogether, herbal Butterbur used alone or combined with other herbal medicine may be considered a functional herbal for prevention and combined with the primary medicine for the treatment of Somatoform disorder with no serious side effects,

References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)

Herbal Aloe Vera, a Potent Mouth Wash for the Prevention and Treatment of Gingivitis with No Side Effects

By Kyle J. Norton

Scientists may have found a low-cost natural gel or mouthwash with no side effects, according to the studies.

Gingivitis is a condition characterized by the inflammation of gum or gum disease.

Most causes of gingivitis in the general population are associated with long-term poor hygiene.

However, People who are smoking and chewing tobacco, having certain medical conditions such as diabetes or consuming oral contraceptives, steroids, anticonvulsants, calcium channel blockers are also at a higher risk of gingivitis.

Untreated gingivitis can lead to a serious infection of periodontitis, the major causes of tooth loss in adults, according to the American Dental Association.

Most cases of untreated gingivitis can also induce complications of bad breath, persistent gum bleeding, and receding gums.

Treatments of gingivitis are to control the infection and totally depending on the stages of the disease. However, regardless of the type of treatment, patients are all required to keep up good daily care at home.

People who smoke or tobacco chewing in some cases may be advised to quit or reduce the amount of intake per day.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

The herbal plant is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

With an aim to find a natural compound for the prevention and treatment of gingivitis with no side effects, researchers at the University of Fortaleza examined the effect of Aloe vera in a randomized, parallel and double-blind clinical trial.

The study included 30 participants randomly allocated to the test group (n=15) dentifrice containing Aloe vera - or the control group (n=15) - fluoridated dentifrice and participants were asked to brush their teeth with the control or test dentifrice, three times a day, during a 30-day period.

According to the Plaque index (PI) and gingival bleeding index (GBI) assessed at days 0 and 30, a significant reduction on plaque and gingivitis in both groups, but no statistically significant difference was observed among them.

The result suggested that the dentifrice containing Aloe vera exerted the similar effects as that of fluoridated dentifrice against plaque and gingivitis.

Furthermore, a total of 45 patients who were diagnosed with plaque-induced gingivitis included in the study. were divided into three groups with fifteen patients in each group to evaluate the effects of Aloe vera.

Group 1 was asked to rinse with 10 ml of aloe vera mouthwash twice daily for three months. Group 2 were treated with scaling only. Group 3 patients were asked to rinse with aloe vera mouthwash and scaling was done.

According to the data obtained at the baseline, end of the first month, and the end of the third month, all three groups showed a significant reduction in gingival inflammation. Aloe vera mouthwash showed the greatest effect compared to other groups.

The results were attributed to the Aloe vera anti-inflammatory activity.

Dr.Ajmera N, the lead scientist said, "it (Aloe vera) can be used as an adjunct to mechanical therapy for treating plaque-induced gingivitis".

Taken altogether, herbal Aloe vera may be used as a mouthwash for the prevention and treatment of gingivitis with on side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References

(3) Aloe vera: It's effect on gingivitis by Ajmera N, Chatterjee A, Goyal V.(PubMed)
(4) A randomized, double-blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse by Chandrahas B, Jayakumar A, Naveen A, Butchibabu K, Reddy PK, Muralikrishna T.(PubMed)
(5) Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans by de Oliveira SM, Torres TC, Pereira SL, Mota OM, Carlos MX.(PubMed)

Wednesday, 2 January 2019

Phytochemical Sulforaphane (Dithiolthiones), the Best for the Prevention and Treatment of Lung Diseases

By Kyle J. Norton

Scientists may have found a bioactive compound for the prevention and treatment of lung diseases with no side effects, according to studies.

Lung diseases are medical conditions, affecting the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.

People with lung diseases have breathing problems, preventing them to get enough oxygen for the body needs.

According to the statistic from the World Health Organization, respiratory diseases are leading causes of death and disability in the world. chronic obstructive pulmonary disease (COPD) and asthma are 2 of the most common respiratory disease in the world, affecting 65 million and 334 million people, respectively.

3 million people die from the chronic obstructive pulmonary disease (COPD) each year, making it the third leading cause of death worldwide. And 14% of 334 million people suffer from asthma are children.

Long-term smoking is considered one of the leading risk factor of lung diseases. Other risk factors associated with the onset of lung diseases include radon, Asbestos, second-hand smoke, and air pollution.

Depending on the are of the respiratory system effect. Lung diseases can be classified to

* Lung disease affecting the airway include asthma and COPD.

*Lung diseases affecting the air sac include pneumonia and tuberculosis.

* Lung diseases affecting the interstitium include interstitial lung disease.

* Lung diseases affecting the blood vessel include pulmonary embolism (PE).

* Lung diseases affecting the pleura include pleural effusion.

* Lung affecting the chest wall include obesity

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

With an aim to find a natural compound for the treatment of lung diseases researchers examined the effects of sulforaphane (SF) in the protein Nuclear factor-like 2 (Nrf2) in mice from arsenic-induced toxicity.
Where Nuclear factor-like 2 has been found to protect the body against a broad spectrum of diseases induced by environmental exposure to harmful substances through its detoxed activity.

Selected mice were exposed to 2 weeks of arsenic-containing dust. At the end of 2 weeks, tested mice showed pathological alterations, oxidative DNA damage, and mild apoptotic cell death in the lung.

Pretreatment of sulforaphane activated the expression of Nrf2 only blocked the alternation caused by arsenic-containing dust but also restored all the damages induced by the substances.

Furthermore, SF-mediated activation of Nrf2 also alleviated inflammatory responses by modulating cytokine production, thus reducing the oxidative stress in the tested mice.

These results clearly suggested that dietary intervention which targets the Nrf2 activation may have a significant effect in the reduction of adverse health effects associated with arsenic exposure.

In the mouse model, activation of NRF2 protein was also found to regulate the rhythmic expression of antioxidant genes involved in glutathione redox homeostasis in the mouse lung.

Moreover, in vivo bleomycin-induced lung fibrosis model, pretreatment of SF restored the lung function by blocking the phenotype caused by bleomycin.

According to the observation of the lungs of the arrhythmic Clock(Δ19) mice, SF increased the levels of NRF2 and glutathione, the antioxidants enzymes produced by the host mice.

The results suggested that NRF2 activated by SF not only inhibited the oxidative damage but also protect the tested mice lung against fibrositis.

Dr. Pekovic-Vaughan V, the lead scientist, after taking into account co and confounders, said, "Our findings reveal a pivotal role for the circadian control of the NRF2/glutathione pathway in combating oxidative/fibrotic lung damage, which might prompt new chronotherapeutic strategies for the treatment of human lung diseases, including idiopathic pulmonary fibrosis".

However, in wildtype neonatal mice exposed to hyperoxia. SF also found to activated Nrf2 activation through induced expression of anti-oxidant genes but did not attenuate alveolar growth arrest caused by exposure to hyperoxia.

These discovery strong suggested that activation of activated Nrf2 may have a certain limit in protecting the lung and lung tissues against alveolar growth exposed to an excess supply of oxygen (O2) or higher than the normal partial pressure of oxygen.

Taken altogether, depending on the types of lung diseases, bioactive compound sulforaphane may be used for the prevention and combined with the primary therapy for the treatment of lung diseases with no side effects.

References
(1) Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. by Zheng Y1, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. (PubMed)
(2) Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status by McGrath-Morrow SA1, Lauer T, Collaco JM, Lopez A, Malhotra D, Alekseyev YO, Neptune E, Wise R, Biswal S.(PubMed)
(3) The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis by Pekovic-Vaughan V1, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ.(PubMed)

Phytochemical Allicin, the Bioactive Compound with Anti Gastric Cancer Potential

By Kyle J. Norton

Scientists may have found a natural and single ingredient for the prevention and treatment of gastric cancer with no side effects, according to the studies.

Gastric cancer is a condition caused by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

At the later stage, liver cancer cells may travel a distance away from the liver to infect other healthy tissue, leading to secondary metastasis through blood and fluids circulation.

According to the American Cancer Society, every year, approximately 26,000 cases of stomach cancer will be diagnosed (16,000 in men and 9,000 in women). The cancer causes the death of over10,000 people, including 6,000 men and 4,000 women).

The cause of gastric cancer is a result of the alternation of cell DNA in the stomach. Researchers do not know what causes the cell DNA alternation, but they do know certain risk factors such as smoking, family history, genetic preposition, certain diseases associated with the stomach and previous stomach surgery are involved the onset of the disease.

However, some researchers suggested that infection caused by Helicobacter pylori is the most important risk factor for gastric cancer.

Dr. Lydia E. Wroblewski, the lead author examined the effects of Helicobacter pylori in the risk of gastric cancer wrote, "Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer".

And, "Infection with H. pylori is the strongest known risk factor for gastric cancer, which is the second leading cause of cancer-related deaths worldwide".

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find the natural compound for the treatment of gastric cancer with no side effects, researchers evaluated the allicin, an active compound derived from garlic anti-cancer effects.

Allicin injection reduced cell viability in a dose- and time-dependent manner, partly through induction of apoptosis in gastric cancer cells.

At the molecular level, allicin induced cancer death through degradation of cancer cells through activation of the proteins associated with the stimulation of cell apoptosis, including the caspase-3, -8, and -9 and Bax and fas expression.

Allicin treatment also inhibited proliferation and induced apoptosis in SGC-7901 cancer cells.

Dr. the lead researcher said, "Data from the current study demonstrated that allicin should be further investigated as a novel cancer preventive or therapeutic agent in control of gastric cancer, with potential uses in other tumor types".

In a total of patients with progressive gastric adenocarcinoma, whose diagnosis was by gastroscopy and pathological examination assigned to 2 groups, 40 in each group, researchers examined the effects of local application of allicin via gastroscopy on progressive gastric carcinoma.

Allicin group showed the cell apoptosis rate of 9.60 +/- 1.52%, the percentage of cell in G0/G1 phase of 72.12 +/- 8.35%, in G2/M phase 9.54 +/- 3.20%, and PI 27.80 +/- 8.35, compared to the rate of 2.20 +/- 0.58%, 69.56 +/- 5.15%, 13.20 +/- 3.05%, and 30.40 +/- 5.15 in control.

The efficacy of allicin was attributed to the inhibition of the function of a protein (gene Bcl-2) associated with cancer cell anti-apoptosis and exhibition of the function of proteins (gene Bax and Fas) associated with the pro-apoptosis.

These results suggested that local application of allicin via gastroscopy can inhibit the cell growth and proliferation of progressive gastric carcinoma, and can also promote gastric carcinoma cell apoptosis, according to the final report by Fourth Affiliated Hospital of Hebei Medical University.

Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with the primary medicine for the treatment of gastric cancer

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
(3) Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk by Lydia E. Wroblewski,1,* Richard M. Peek, Jr.,1,2,3 and Keith T. Wilson. (PMC)

Phytochemicals Phytic Acid, the Anti Prostate cancers Bioactive Compound

By Kyle J. Norton

Phytochemicals phytic acid may be the next generation natural ingredient for the prevention and treatment of prostate cancer, some scientists found.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body.

As cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cell can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction.

Symptoms which are not found in enlarged prostate include blood in the urine and blood in the seminal fluid.

If you are experiencing some of the above symptoms, please check with your doctor to rule out the possibility of prostate cancer

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome and genetic proposition are some risks actors associated with the onset of the disease.

Some researchers suggested that a poor diet is one of the major risk factor found in patients with the disease.

Dr. Amir Bagher, the lead scientist evaluated the dietary patterns and risk of prostate cancer wrote, "After adjustment for potential confounders, a healthy dietary pattern was associated with decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81; trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037)".

And, "an unhealthy dietary pattern was associated with an increased risk of prostate cancer. However, a healthy dietary pattern was associated with a decreased risk of prostate cancer".

The results strongly suggested that by following a healthy diet pattern, one can substantially reduce the risk of prostate cancer.

Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

On finding a natural ingredient for the treatment of prostate cancer with no side effects, researchers assessed the effects of phytic acid (inositol hexakisphosphate (IP6)) on the activation of phosphoinositide 3-kinase (PI3K)-Akt pathway in promoting survival, proliferation, and angiogenesis in human prostate cancer cells.

In invasive human prostate cancer, PC-3 and C4-2B cells, IP6 treatment of cells suppressed proliferation, induced apoptosis through protein associated with the apoptotic and cell death programming pathways.

Phytic acid also inhibited cancer cells through protein associated with cancer cell growth, proliferation, differentiation, motility.

Furthermore, IP6 inhibited transcription and cell migration. through cell cycle arrest at the G1 phase.

Dr. Gu M, the lead scientist, after taking into account co and confounders said, " IP6 suppresses cell survival, proliferation, and angiogenesis but induces death in prostate cancer cells, which might have translational potential in preventing and controlling the growth of advanced and aggressive prostate cancer for which conventional chemotherapy is not effective".

In advanced and androgen-independent human PCa PC-3, Treatment of PC-3 cells with 2 mM IP6 strongly inhibited both growth and proliferation and decreased cell viability; similar effects were also observed in other human PCa DU145 and LNCaP cells.

IP6 also caused a strong apoptotic death of PC-3 cells through proteins associated with the activation of cell death programming and induced apoptosis.

The inhibition of PC-3 cancer cell line by IP6 also is associated with the inhibition of the protein involved cells proliferation, differentiation, similar to that of the above study.

Interestingly, researchers also discovered that IP6 also inhibited the transcription factor activity in promoting cancer cell growth and reproduction and regeneration

Where a transcription factor (TF) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA.

Taken altogether, phytochemicals phytic acid may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of prostate cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target by Gu M, Roy S, Raina K, Agarwal C, Agarwal R.(PubMed)
(2) Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells. by Gu M, Raina K, Agarwal C, Agarwal R.(PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, Seyed Mostafa Nachvak, Mansour Rezaei, 3 Mozhgan Moravridzade, Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

Tuesday, 1 January 2019

Chinese Celery, the Prominent Post Stroke Treatment Functional Food

By Kyle J. Norton

Scientists may have found a whole food for the treatment and improvement of the quality of life of post-stroke patients and without inducing any side effects, according to studies.

Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.

In other words, stroke can either be results of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain with inducing permanent damage.

Depending on the parts of the neuron being damage, patients may experience different symptoms. However, most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking and persistent headache.

Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, ethnicity are some prevalent risk factors of stroke.

Out of many risk factors, people who have hypertension, particularly untreated hypertension and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.

In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat and processed foods have been found in the high percentage, compared to the traditional diet.

Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in risk of stoke wrote, " adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".

The statement clearly suggested that a healthy diet rich in fruits and vegetable and whole grain and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

On finding a natural ingredient with no side effect for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.

The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of onset of ischemic stroke in China.

Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.

After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement than 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).

Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.

According to Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.

Furthermore, on a stroke induced by the middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), researchers compared the results of the pre-treatment of NBP administered to SHR and WKY daily for two months prior to MCAO and post-treatment of NBP given daily for seven consecutive days after MCAO.

In SHR, NBP pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area compared to oil-vehicle treated controls.

In other words, NBP pre- and post-treatment reduced the potential damage penumbra area through its neuroprotective activity.

However, in WKY, these beneficial effects were observed only in the post-treatment group, compared to SHR.

Dr. Zhang L, at the end of the experiment, wrote, "NBP could exert both preventive and therapeutic effects on ischemic stroke in SHR, but only exerted a therapeutic effect in WKY".

Taken altogether, Chinese celery processed high amounts of Dl-3-n-butylphthalide (NBP) may be considered a functional food for the post-treatment of patients with stroke.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(2) DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT.(PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)