Herbal Cat' claw, The Herb Which Balances the Levels of Free Radicals and Antioxidants in the Body

By Kyle J. Norton


Herbal Cat'claw may process a potential effect in balancing the ratio of free radicals and antioxidants in the body, some scientists suggested.

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.

They may have positive, negative or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.

Imbalance of the ratio of free radicals and antioxidants linking to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states or reduced levels of antioxidant enzymes in the human.

In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".

The results clearly indicated, if our body can not produce the levels of antioxidant to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from the foods, herbs and synthetic sources may be necessary.

Some researchers also suggested that antioxidants from the food and herbal sources have been found to exert the significant effect in stimulating the antioxidants produced by the host tissue.

Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.

The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In the aim to reaffirm the tradition use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavanols isolated from the herb.

In vitro, application of alkaloids and flavanols isolated from the herb demonstrated significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.

 The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.

Oral pretreatment for 3 d with UT protected against indomethcin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis. 

This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine 

Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of with 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).

The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.

In immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes over the control value along a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).

Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.


* The alcoholic preparations exerts higher antioxidant activity and total phenolic compounds compared
Although the alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.


Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for treatment of overexpression of oxidative stress-related diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

Herbal Catnip, the Natural Insect Repellent, Scientists Suggested

By Kyle J. Norton, Master of Nutrition

Scientists may have found a natural repellent which protects our skin against insect biting without inducing any side effects, some scientists suggested.

In the rating of products that work best against mosquitoes and ticks, the consumer report found that deet (N, N-diethyl-meta-toluamide) is one of the best to protect us against mosquitoes and ticks, Any products that contain 15 to 30 percent deep can provide long-lasting protection.

However, large oral doses of deep were found to induce symptoms of nausea, vomiting, bradycardia, and seizures. In serious cases, deet can cause cardiotoxicity. Contact exposure to deet also has the potential for dermal effects, leading to numbness and redness of the applied area, according to the study "Neurotoxicity and Mode of Action of N, N-diethyl-meta-toluamide (DEET)" by Dr. Daniel R. Swale.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The herb has bused use in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

In the study to evaluate the effects herbal Catnip as an effective mosquito repellent against several Aedes and Culex species, both topically and spatially, researchers launched a study of the essential oil of the herb in laboratory bioassays.

Catnip essential oil (at a dosage of 20 mg) resulted in average repellency rates of 96% against stable flies, Stomoxys calcitrans (L.) and 79% against houseflies, Musca domestica (L.), respectively.

Catnip oil use as a potential biting and nuisance insect repellent in urban settings was a moderate irritant with non-irritating to the eye.

Dr. Zhu JJ, at the final report, said, " In comparison with other U.S. Environmental Protection Agency-approved mosquito repellents (DEET, picaridin and p-menthane-3,8-diol), catnip oil can be considered a relatively safe repellent, which may cause minor skin irritation".

Additionally, in the findings of a safer fly control strategies, researchers at the U.S. Department of Agriculture (ARS-USDA) launched an investigation of the effectiveness of catnip (Nepeta cataria L.) oil and its constituent compounds, nepetalactones, as stable fly repellents.

Injection of essential oil of catnip reduced the feeding of stable flies by >96% in an in vitro bioassay system, compared with other sesquiterpene-rich plant oils.

Catnip oil demonstrated strong repellency, compared to others chemicals for repelling biting insects, including isolongifolenone, 2-methylpiperidinyl-3-cyclohexen-1-carboxamide and (1S,2'S)-2-methylpiperidinyl-3-cyclohexen-1-carboxamide.

After taking into account of co and confounders Dr.Zhu JJ, the lead author said, " In field trials, two formulations of catnip oil provided >95% protection and were effective for up to 6 h when tested on cattle. Catnip oil also acted as a strong oviposition repellent and reduced gravid stable fly oviposition by 98%".

Taken altogether, there is no doubt that Catnip essential oil can be considered an effective insect repellent natural remedy. 

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent by Zhu JJ1, Zeng XP, Berkebile D, DU HJ, Tong Y, Qian K.(PubMed)
(2) Nepetalactones from essential oil of Nepeta cataria represent a stable fly feeding and oviposition repellent by Zhu JJ1, Berkebile DR, Dunlap CA, Zhang A, Boxler D, Tangtrakulwanich K, Behle RW, Baxendale F, Brewer G.(PubMed)

Manuka Honey, the Best for Tissue Regeneration

By Kyle J. Norton

Scientists may have found a whole food which processes a significant effect in stimulating the regeneration of tissue, some study suggested.

Tissue regeneration is an act of regrowing non-injured tissues from the remaining tissue. Cells in the non-injured tissues are naturally regenerated over time by replaying the cells that have gone through certain cycle division and die.
One example is the liver grows back to its original size, though not its original shape.

However, the action totally contrasts to wound healing due to injury, involving the closing up injury site with a scar.

In fact, certain amphibians such as salamanders can regenerate lost limbs; skates, rays, and phylum Annelida, such as worms can even grow into two new, separate worms if they're cut in half.

Human, on the other hand, process very limited regeneration abilities.

According to the article "Tissue Regeneration" by Bob Hirshon wrote, "By blocking the function of just two proteins, called Rb and ARF, Blau's team was able to make mouse muscle cells regenerate like new cells"

"However, the new muscle cells merged successfully with the old cells only if the researchers turned Rb back on. If they didn't, the new cells grew too much and interfered with the function of the old muscle cells. In other words, they became tumors. And in fact, the function of both Rb and ARF in mammals is to suppress the growth of tumors".

Therefore, many works needed to be done. Dr. Vincent Falanga, the lead author in the study "Stem Cells in Tissue Repair and Regeneration" said, "We should remain hopeful that true regeneration is possible in adult human tissues. Thus far, the evidence has not been very encouraging, except for fetal wound healing" and 

"We show Figure 1 to indicate the immense difficulties underlying chronic wounds. Regeneration of the tissue shown in the Figure would be extremely difficult, and would most likely first require complete removal of the non-healing and affected skin".

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient and whole food processed the tissue degenerative activity without inducing any side effects, researchers at the Tehran University of Medical Sciences and Khyber Medical University evaluated the effects of Manuka honey in wound healing, epithelial regeneration.

A joint study was conducted by searching the wide spectrum sources from Google Scholar, PubMed, and Scopus.

Studies included in the investigation all suggested that Manuka honey not only processes anti carcinogenesis by controlling different molecular processes, and progression of cancer cells but also engineers the tissue regeneration. 

The antibacterial property and tissue regeneration were attributed to the bioactive compound methylglyoxal (MGO) found abundantly in the honey.

After taking into account co and confounders, Dr. Niaz K wrote in the final report, "Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property".

In order to understand the action of Manuka honey in tissue regeneration, researchers examined the effect of a scaffold electrospun based on polyurethane (PU), grape seed oil, honey, and propolis.

The prepared PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold showed enhanced tissue regeneration through maintaining the thermal stability and reducing surface roughness compared to the control.

According to the hemolytic assay and cytocompatibility, the electrospun PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold promoted the tissue regeneration through enhancing the red blood cells (RBC) and human fibroblast cells (HDF).

These result clearly suggested that the newly developed scaffold electrospun might be used as an alternative candidate for bone tissue engineering applications, Dr. Chao CY suggested.

Taken altogether, Manuka honey may be considered a functional food for speeding up wound healing and tissue regeneration, pending to the larger and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

(1) Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration by Niaz K1, Maqbool F1, Bahadar H2, Abdollahi M1.(PubMed)
(2) Engineering electrospun multicomponent polyurethane scaffolding platform comprising grapeseed oil and honey/propolis for bone tissue regeneration by Chao CY1, Mani MP2, Jaganathan SK3,4,5. (PubMed)
(2) Honey: an effective regenerative medicine product in wound management by Martinotti S1, Bucekova M2, Majtan J2, Ranzato E3. (PubMed)
(3) Tissue Regeneration by Bob Hirshon
(4) Stem Cells in Tissue Repair and Regeneration by Vincent Falanga, MD (PMC)

Ruscogenin Isolated from Herbal Butcher's broom, the Potential Anti Acute and Chronic Inflammatory Diseases Remedy, Scientists Say

By Kyle J. Norton, Master of Nutrition

Scientists may have found a potential herbal medicine's ingredient for the treatment of acute and chronic inflammation with no side effects, some studies suggested.

Inflammation is a systematic immune response during the acute phase of infection.

Macrophages, one the lymphocytes and the first line defense of the immune system after sensing the damage of localized tissue, stimulate the production of proinflammatory cytokines to the site to protect the body against invasion of potential pathogens.

However, in some cases, overexpression of proinflammatory cytokines can cause the death of nearby healthy cells, leading to abnormal skin healing and formation of irreversible scars.

Chronic inflammation is a result of a prolonged period of inflammation that lasts for several months and even years caused by the inability of the immune system to kill off all harmful microorganisms during the acute phase of infection.

Chronic inflammation can also be caused by an autoimmune disorder in which immune system continuously attacks normal and healthy tissue, by mistaking them for the causable pathogens.

Low-grade inflammation is a different type of chronic inflammation characterized by a production of the inflammatory cytokines in a low-grade state.

Epidemiological studies, linking chronic inflammation to certain diseases such as heart disease or stroke, has been under investigation in many scientistic communities. However, as of today, scientists still do not know why people with the same health conditions and family history, some are susceptible to the onset of chronic inflammation while others do not.

If you experience some of the symptoms such as persistent body pain, fatigue, and insomnia. depression, anxiety and mood disorders, gastrointestinal complications and frequent infection. Please check with your doctor to rule out the possibility of certain diseases.

Butcher's broom is a low evergreen shrub, a species of Ruscus aculeatus, belonging to the family Asparagaceae, native to Eurasia.

The herb has been used in herbal medicine to treat reduce inflammation, Peripheral vascular disease, Hemorrhoids Bronchial asthma, Varicose veins, Hypotension, Jaundice, functional disorders of the heart, kidney disorder, venotonic and anti-oedematous properties, etc..


The chemical ingredients include rutin, sitosterol, sparteine, spirostanol saponins, steroidal sapogenins, sterols, stigmasterol, sulfated steroidal saponins, sweet broom, tetracosanoic acid, triterpenes, triterpenes, and tyramine.

In the study to reaffirm traditional Chinese medicine use of Butcher's broom for the treatment of -inflammation and thrombosis, researchers at the China Pharmaceutical University, Nanjing launched an investigation to examine the anti-inflammatory and anti-thrombotic activities of Ruscogenin (RUS), isolated from Butcher's broom.

Application of ruscogenin demonstrated a remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) damage by the proinflammatory factor tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner, in vitro.

On leukocyte migration and celiac prostaglandin E(2) (PGE(2)) level induced by zymosan A in mice, injection of ruscogenin significantly suppressed zymosan A-evoked peritoneal total leukocyte migration in the initiation of inflammation, in mice in a dose-dependent manner, while the bioactive had no obvious effect on PGE(2) content in peritoneal exudate cells, participating in the forming of exudate during inflammation.

These results suggested that ruscogenin exerts a significant anti-inflammatory activity by inhibiting TNF-alpha and suppressing NF-kappaB activation in the inflammatory response during bacterial infection.

On the development of monocrotaline (MCT)-induced inflammation of pulmonary arterial hypertension (PAH). in rats, researchers found that

* Application of ruscogenin displays a strong effect on hemodynamics and pulmonary vascular inflammatory remodeling and preventing the development of PAH 3 weeks after injection of MCT.

* Ruscogenin inhibits the lung inflammation by reducing expression of inflammatory cytokine and immune leukocyte infiltration by limiting the action of nuclear factor (NF)-κB in the activation of the immune response.

Additionally, ruscogenin also restores the function of pulmonary arterioles and prevent the death of endothelial cell induced by the injection of MCT.

Taken altogether, herbal Butcher's broom processes high amounts of bioactive ingredient ruscogenin may be considered an adjunct therapy or combined with conventional medicine for treatment of acute and chronic inflammatory diseases, pending to the large example size and multi-center studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB by Huang YL, Kou JP, Ma L, Song JX, Yu BY. (PubMed)
(2) Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats by Bi LQ, Zhu R, Kong H, Wu SL, Li N, Zuo XR, Zhou SM, Kou JP, Yu BY, Wang H, Xie WP. (PubMed)

Herbal Cayenne, the Anti Cancers Functional Food, Scientists Find

By Kyle J. Norton, Master of Nutrition

Scientists may have found a kitchen spice which processes a potential for reducing risk and treatment of cancers, some studies suggested.

Cancers are a class of chronic and medical conditions characterized by cells growth irregularly and disorderly.

Most cancers start on the surface of the inner lining of organ tissue. At this early stage, patients may not experience any symptoms.

At the later stage, most cancerous cells can travel a distance away from the original site to infect other healthy tissue via fluid and blood circulation.

As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, some are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.

There are many prevalent risk factors associated with the cancer onset, depending on the primary location, including an increase of age, excessive alcohol consumption, exposure to chemical toxins and sunlight, and infectious pathogens.

Noticeably, in the study of "Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals" conducted by the joint investigation lead by the Jordan University of Science and Technology, Dr. Omran S, the led author said, "Colorectal cancer (CRC) risk is expected to continue rising due to dietary patterns, sedentary lifestyle, and other practices" and "Data was collected using a self-report questionnaire measuring sociodemographic characteristics, dietary habits, physical activity, and lifestyle risk factors of CRC. The mean age of participants was 57.0 ± 8.56 years. The majority of participants were male (71.8 %) and with less than secondary school formal education (60.7 %). The commonest risk factors for CRC among the participants were overweight or obesity (76.1 %), lack of exercise (71.6 %), limited consumption of vegetables (70.8 %), smoking (60.6 %), over-consumption of red meat (56.3 %), and diabetes mellitus (24.1 %)".

These results suggested that by following a healthy diet with less saturated and trans fat, red meat and processed food and more in fruits and vegetables and lifestyle, the risk of cancers can be reduced substantially.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The spicy herb has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.


Chemical ingredients
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

In the study to examine whether Capsaicin, a pungent phytochemical in a variety of red peppers processes an anti-proliferative effect on numbers of cancer, researchers at the Changhua Christian Hospital, launched an investigation of cell proliferation/viability and cytotoxicity of KB cells exposed to capsaicin.

On the human KB cancer cells, application of capsaicin exerted a significant effect in reducing cancer cell proliferation/viability and induced cell death in a dose-dependent manner compared to untreated control.d t

In cell cycle analysis, capsaicin inhibits cancer cell division n in cell cycle arrest at G2/M phase of KB cells.

Further analysis suggested that capsaicin growth inhibition of KB cells was attributed mostly in the induction of cell apoptosis, through disrupting the pathway associated with cancer cellular response in differentiation, proliferation, and survival.

Interestingly, in the concerns that diet pattern and selection may be associated with the risk of cancer onset, researchers at the Inst. of Cytology and Preventive Oncology (ICMR) launched an investigation to examine the effects of Indian diet's many unique dietary constituents, including spices like chili pepper, cloves, black pepper and black cumin on the cancers' risk.

Application of pungent spice including red pepper extract exerted a cell antiproliferative activity against the TE-13 (esophageal squamous cell carcinoma) cell line.

All extracts showed cytotoxic activity, but aqueous extracts of red pepper were found to be more potent than alcoholic extracts.

In morphological analysis, DAPI staining and DNA fragmentation assay, the aqueous extract of chili pepper at 300 μl/ml. demonstrated maximum cell death and apoptotic cell demise (88%) to occur within 24 hours compared to other pungent spicy extracts.

The finding suggested that herbal Cayenne containing a high amount of capsaicin may be considered a functional food and an adjunct therapy for reducing the risk of cancers with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Capsaicin induces cell cycle arrest and apoptosis in human KB cancercells by Lin CH, Lu WC, Wang CW, Chan YC, Chen MK. (PubMed)
(2) Cytotoxic potential of Indian spices (extracts) against esophageal squamous carcinoma cells. (PubMed)
(3) Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals by Omran S1, Barakat H2, Muliira JK3, McMillan S. (PubMed)

Chaste Tree Berry (Vitex agnus-castus), in the Prevention and Treatment of Cancers

By Kyle J. Norton, Master of Nutrition


Chaste tree berry may have a potential effect in reducing risk and treatment of cancers, some studies proposed.

Cancer is the class of medical and chronic disease characterized by the irregular cells growth, that starts on the cells on the surface of the inner lining of the organ tissue.

At the later stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue through DNA alternation visa fluid and blood circulation.

The exact causes of cancer are unknown. As of today, researchers do not know why people with the same health and family history, some are susceptible to the onset of the disease while others do not.

According to the statistic provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with some forms of cancer at some point during their lifetimes.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, causing 1,790 death.

Epidemiologically, depending on the primary onset of the disease, the most common risk factors of cancer are aging, tobacco, sun exposure, radiation exposure, chemicals, and toxic substances, certain hormones therapy, and family history,

However, excessive alcohol, poor diet, lack of physical activity, or being overweight also are considered some major acquired risks of cancer.

Dr. Karen Basen-Engquis, the lead author in the concerns of obesity in risk of cancer wrote, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%.".

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,

The queen herb has been used in herbal medicine for thousands of year as an anaphrodisiac herb. It is considered a Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time.

There was a report that chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria.

In the findings a natural extract which proceeds anti-cancer potency, researchers at the launched an investigation to examine the anticancer extract preparation ethanol from dried ripened Vitex agnus-castus fruits growing in Israel (Vitex extract) against human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

In the cell cultures, application of different concentration of Vitex extract after culture for 24 h (logarithmic growth phase) or 72 h (stationary growth phase), exerted a significant cytotoxic activity against all cell lines in logarithmic growth-phase cells, comp[ared to stationary growth-phase cells.

DNA fragmentation, an indication of cancer cells undergoing apoptosis was seen in SKOV-3, KATO-III, COLO 201, and Lu-134-A-H cells.

Furthermore, Vitex extract-treated KATO-III cells also inhibited the expression of heme oxygenase-1 and the active forms of caspases-3, -8 and -9 which play a critical role in the protection the cancer cell against cytotoxicity.

Dr. Ohyama K, the lead author, said, "(The) cytotoxic activity of Vitex extract may be attributed to the effect on cell growth, that cell death occurs through apoptosis, and that this apoptotic cell death may be attributed to increased intracellular oxidation by Vitex extract treatment".

In a human gastric signet ring carcinoma cell line, KATO-III. further analysis also suggested that application of ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) decrease the antioxidant enzyme produced by the cancer cells without affecting the levels of the level of GSSG, another indication of oxidative stress increased in the cancer cells.

The result indicated that, Vitex-induced apoptosis through intracellular oxidative stress and mitochondrial membrane damage through decreasing the antioxidant defense of the cancer cell lines.

Taken altogether, Chaste Tree Berry may be considered a functional food and adjunct therapy for the prevention and treatment of cancers, depending on the result of the large and multi-center studies in human consumption of the herb during the course of diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

Papaya, the Pharmacological Target Anti High Blood Cholesterol Functional Food

By Kyle J. Norton

Papaya may be considered a functional food of high blood cholesterol with inducing any side effects, some scientists suggested.

Cholesterol, a waxy substance produced by the liver or from the intake of dietary sources plays an important role in the building of cell membranes in transmitting information among cells and making steroid hormones, fat-soluble vitamins, and bile acids for digestive system need.

There are 2 major types of cholesterol, 

* Low-density lipoproteins (LDL) are also known as“bad” cholesterol. High levels of LDL cholesterol can block the arteries, causing heart disease. and

* High-density lipoproteins (HDL) are known as“good” cholesterol. HDL cholesterol removes bad cholesterol from other parts of your body and carries them back to the liver.

The healthy ratio of total cholesterol is 4 (bad cholesterol)/1(good cholesterol). If you total blood cholesterol is lower than 4, you are considered a have a healthy level of blood cholesterol.

The Mayo Clinic in the article talking about diet and lifestyle effect in high blood cholesterol wrote, "Poor diet. Eating saturated fat, found in animal products, and trans fats, found in some commercially baked cookies and crackers, can raise your cholesterol level. Foods that are high in cholesterol, such as red meat and full-fat dairy products, will also increase your total cholesterol".

Therefore, by change your diet pattern with more in fruits, whole grain and vegetables and less in saturated and trans fat, red meat and processed food, and following a healthy lifestyle with moderate exercise, you should be free of the syndrome of high blood cholesterol, regardless of your present conditions.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries


Chemical constituents of papaya include
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.

In the reaffirming of the traditional use of Ficus carica (papaya) for the treatment of several metabolic syndrome-related health problems, researchers at the University of Florida launched an investigation to examine the preventive effects of a Ficus carica (FC) leaf extract on hyperlipidemia in high-fat diet (HFD)-induced obese male rats.

Male Sprague-Dawley rats (180-200 g) were fed with a regular diet, HFD or a HFD + oral treatment of either 50 mg/kg or 100 mg/kg of FC or 30 mg/kg pioglitazone for six weeks.

At the final report, researchers found that
* Oral administration of FC exerts a significantly anti hyperlipidemia effect by lowered triglycerides (TG), interleukin-6 (IL-6) levels and elevated high-density lipoprotein cholesterol (HDL-C) in the tested animal.
* The effects of FC on lipid parameters are more pronounced in treated rats than those of the positive control pioglitazone.

* FC treatment group also significantly lowered atherogenic index (AI) and the coronary risk index (CRI). the indications of the decreased risk of atherosclerosis and coronary artery disease.

Dr. Joerin L, the lead author said, "preventive treatment with FC significantly improved the lipid profile and decreased adipogenic risk factors in HFD rats most likely mediated through an increase in HDL-C levels".

Additionally, in the evaluate the effects of the fruit and latex of papaya used in the folk medicine for treatment of hyperlipidemia, researchers conducted an experience to examine the anti-hyperlipidemic effect of the ether- and water-soluble fractions of C. papaya ethanol extract in olive oil-induced hyperlipidemic rats.

The extract and fractions were administered orally at doses of 200 and 400 mg/kg body weight in rats. Olive oil (5 mL/kg oral dose) was administered 30 min after treatment.

Oral administration of papaya extract in a dose-dependently inhibited the total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL) level, and significantly increased high-density lipoprotein (HDL) level.

Papaya also exerted a significant acute effect on HDL level and TC and TG elevation induced by olive oil.

These results suggested that papaya extract and water fraction showed protective action by increasing the HDL cholesterol level and lowering the levels of HDL level and TC and TG elevation in hyperlipidemic rats.

Taken all together, papaya may be considered a functional food for treatment of high blood cholesterol.

However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of papaya antihyperlipidemic possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(2) Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C by Joerin L1, Kauschka M, Bonnländer B, Pischel I, Benedek B, Butterweck V.(PubMed)
(3) Effect of ether- and water-soluble fractions of Carica papaya ethanol extract in experimentally induced hyperlipidemia in rats by Iyer D1, Sharma BK, Patil UK. (PubMed)