Phytochemical Piperine Cuts Off Energy Supply of Cancer Cells, Scientists Find

By Kyle J. Norton

Piperine, a phytochemical alkaloid in the class of organosulfur compound may have a significant effect in blocking the energy that is necessary for cancer cells proliferation and survival, some scientists suggested.

Angiogenesis is the formation of new blood vessels in the body for healing and reproduction.

However, in invasive cancers, the formation of a new blood vessel from pre-existing vessels stimulated by cancer chemicals may be deadly to the host.

These new blood vessels provide the nutrients and fluids for cancer growth and metastasis.

Cancer is a class of diseases, characterized by cell growth irregularly that starts in the surface of the inner lining of tissue or organs. Patients at the beginning of cancer onset do not experience any symptom.

At the later stage of the progression, the cancerous cell may travel a distance away from the primary site to infect other healthy tissue and organs. If cancer has grown large enough, it may affect other nearby healthy tissue and nerve cells, causing localized symptoms and persistently severe pain.

Angiogenesis occurred are totally depending on a net balance of angiogenic factors and antiangiogenic factors, which are secreted by both tumor cells and host-infiltrating cells. If the tumors angiogenic factors win, the new blood vessels are formed.

Some researchers suggested if we can produce a drug that cuts of the forming of the new blood vessel which supplies energy to cancer, we may cure cancer. 

However, according to the epidemiological studies, antiangiogenic therapy in the inhibition of the growth of the tumor works best in combination with conventional cytotoxic chemotherapy.

Dr. Roberta WC Pang, the lead author in the investigation "Clinical Implications of Angiogenesis in Cancers" wrote, "Recently, a monoclonal antibody against vascular endothelial growth factor, which is one of the most potent angiogenic factors, has been approved for clinical use in colorectal cancer patients after a clinical trial confirmed that combining the antibody with standard chemotherapy regimen could prolong patient survival".

We can only hope that in a distant future, a single miracle drug can have an antiangiogenic potency to block off all cancers proliferation.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

A research team at the Dalhousie University in the investigation of piperine, a major alkaloid constituent of black pepper physiological actions in inhibition of cancer cells proliferation including the killing of cancer cells launched a study to examine the angiogenetic effect of piperine in tumor progression.

Injection of piperine inhibited the proliferation and G(1)/S transition of human umbilical vein endothelial cells (HUVECs) without causing cell death.  

In vitro, piperine also inhibited HUVEC migration and tubule formation and collagen-induced angiogenic activity in rat aorta explants and breast cancer cell-induced angiogenesis in chick embryos.

Importantly, piperine inhibited phosphorylation of Ser 473 and Thr 308 residues of Akt (protein kinase B), which is a key regulator in the induction of cancer cells survival and angiogenetic proliferation.

The findings reconfirmed the function of piperine as an angiogenesis inhibitor for use in cancer treatment.

Additionally, in the finding of the phytochemical which processes a strong effect in improving the function of curcumin,  in the suppression of angiogenesis by inhibiting the curcumin lack of water solubility, and relatively low bioavailability.

After multiple approaches are being sought to overcome these limitations, researchers finally discovered natural curcumin analogs, namely piperine.

 Piperine in the co-administration with curcumin enhanced the functions of curcumin in the suppression of angiogenesis without reducing the antitumor activity.

Taken altogether, piperine may be considered a functional supplement used for the prevention of cancers and an adjunction therapy by cutting the supply of energy of cancer that is life and death for cancer colonization, depending to the further study of a large sample size and multi-center in human consumption.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Piperine, a dietary phytochemical, inhibits angiogenesis by Doucette CD, Hilchie AL, Liwski R, Hoskin DW.(PubMed)
(3) Clinical Implications of Angiogenesis in Cancers by Roberta WC Pang1 and Ronnie TP Poon. (PMC)

Herbal Butcher's broom Extract, The Potential Remedy for Treatment of Chronic Venous Insufficiency (CVI)

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole herb with the ability to treat chronic venous insufficiency without inducing side effects, some studies suggested.

Chronic venous insufficiency (CVI) is a medical condition charactered by decreased function of venous wall and/or valves in the leg veins, leading to reduced blood returning to the heart from the legs. As the results of some blood were pooled or collected in the veins, causing pain, swelling, and skin changes in the legs.

Chronic venous insufficiency, in some cases, may develop due to preposition of deep vein thrombosis (DVT).

There is no single cause of chronic venous insufficiency. Certain risk factors have been found epidemiologically associated with the early onset of the condition, including people with ages over 50, varicose veins, family history of varicose veins,  obesity, pregnancy, female, physical inactivity, an occupation that required extended periods of standing or sitting, smoking.

If you are experiencing some of the symptoms such as persistent swelling in legs and/or ankles, tight feeling calves or itchy painful legs,  pain during walking that stops with rest, brown-colored skin, particularly near the ankles, please check with your doctor to rule out the chronic venous insufficiency possibility.

Untreated CVI can lead to chronic life-threatening infections of the lower extremities. Pain, especially after ambulation, is a hallmark of the disease, said, Dr. Robert Weiss in the article "What is the disease course of untreated venous insufficiency?".

Butcher's broom is a low evergreen shrub, a species of Ruscus aculeatus, belonging to the family Asparagaceae, native to Eurasia.

The herb has been used in herbal medicine to treat reduce inflammation, peripheral vascular disease, hemorrhoids bronchial asthma, varicose veins, hypotension, jaundice, functional disorders of the heart, kidney disorder, venotonic and anti-oedematous properties, etc.


The Chemical Ingredients of Butcher's broom include rutin, sitosterol, sparteine, spirostanol saponins, steroidal sapogenins, sterols, stigmasterol, sulfated steroidal saponins, sweet broom, tetracosanoic acid, triterpenes, triterpenes, tyramine, etc.

In the study to confirm the efficacy of extracts from Butcher's broom rhizome (Ruscus aculeatus) used in the oral treatment of lower leg edema in patients with chronic venous insufficiency, researchers in Germany launched a multi-center, double-blind, randomized, placebo-controlled trial to confirm the safety of a ruscus extract. 

The study includes a total of 166 women suffering from chronic venous insufficiency (Widmer grade I and II, CEAP (Clinical signs, Etiological classification, Anatomic distribution, Pathophysiology) 3-4).

Only the data of 148 patients (30-89 years, 150-182 cm height, 49-97 kg body weight) were selected to the study with a mean disease duration of 14.6 years in the ruscus extract group and 15.1 years in the placebo group. 

Treatment groups demonstrated a significant improvement of the leg volume changes over 12 weeks AUB0-12 (-827 ml x day), the change of leg volume after 8 and 12 weeks of treatment (-16.5 ml and -20.5 ml), changes in ankle and leg circumferences after 8 and 12 weeks of treatment, and the changes in subjective symptoms, heavy tired legs and sensation of tension (week 12) compared to placebo group.

Furthermore, group treat with butcher broom also showed a reduction of symptoms of heavy lower legs, the sensation of tension, and tingling sensation, positively correlated with the changes in leg volume.

Dr. Vanscheidt W, the lead author said, " Considering the study duration of three months it is concluded, that ruscus extract, in the recommended daily dosage according to the German monograph, is a safe and effective treatment for patients suffering from chronic venous insufficiency".

Moreover, with an aim to reassess the effect of Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid (HMC-AA) on the quality of life (QoL) of patients suffering from chronic venous disorders (CVDs, the Cabinet de Phlébologie conducted an observational, multicentre and prospective study including 917 Mexican patients suffering from CVD.

After 12 weeks of treatment of R. aculeatus-HMC-AA, selected physicians then assessed the patients' symptoms and QoL using Short Form (SF-12) and Chronic Venous Insufficiency (CIVIQ) auto-questionnaires.

Application of R. aculeatus-HMC-AA. improved all symptoms and ankle circumferences over time, with increasing clinical, aetiological, anatomical and pathophysiological (CEAP) classes and body mass index (BMI).

The improved scores of all dimensions of the SF-12 indicated a significantly improved quality of life over time.

The results suggested that R. aculeatus-HMC-AA. significantly improved the symptoms and QoL of CVD patients.

Taken altogether, Herbal Butcher's broom extract may be considered adjunct therapy for treatment of

Chronic venous insufficiency without inducing adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Efficacy and safety of a Butcher's broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency BY Vanscheidt W, Jost V, Wolna P, Lücker PW, Müller A, Theurer C, Patz B, Grützner KI. (PubMed)
(2) Assessment of quality of life in Mexican patients suffering from chronicvenous disorder - impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment - 'QUALITY Study by Guex JJ, Enriquez Vega DM, Avril L, Boussetta S, Taïeb C.(PubMed)

Papaya, The Anti Cancer Functional Food Targeted by Chemotherapy and Pharmacology

Kyle J. Norton

Papaya extract may be the next potential pharmacological target to identify the ingredients for the treatment of cancers, some scientists suggested.

Cancer is the class of chronic conditions characterized by the abnormal cell growth caused by the alteration of healthy cell DNA which starts on the surface of the inner lining of the bodily organs.

At the advanced stage, after colonizing most of the tissue of the primary organ, the malignant cells travel a distance away through lymph and blood to infect other healthy tissue and organs.

Researchers do not know why people with similar health conditions, family history, and race, some are susceptible to cell alternation in the initiation of cancer while others do not.

There has not been much success in the debate over whether the cancerous state is originated in a single cell or whether it is a reflection of aberrant behavior on the part of a ‘society of cells’.

The tissue organization field theory (TOFT) suggested that cancer onset is a result of a breakdown of tissue organization involving many cells from different embryological layers. In other words, cancer is a tissue-based disease and that proliferation is the default state of all cells.

The cancer stem cell (CSC) theory hypothesized that cancers are the result of genetic and epigenetic changes that take place within single cells. In other words, cancer is driven by a rare subpopulation of cells, designated cancer stem cells (CSC).

Other researchers proposed that cancer is the rewiring of the cell’s protein interaction networks mediated by intrinsically disordered proteins (IDPs) that drives the tumorigenic process.

In other words, the disorders of signaling proteins and amino acid residues are the culprits which drive the onset of cancers and chronic diseases.

Regardless of the hypotheses, as of the today, the exact causes of cancer are still unknown. Certain risk factors are known to associate with the onset of cancers, including an increase in age, excessive alcohol drinking, cancer-causing chemicals, chronic inflammation, poor diet, hormones therapy, immunosuppression, and infectious pathogens, according to epidemiological studies.

According to the World center fund International, in 2012, there were 14.1 million cancer cases, affecting 7.4 million in men and 6.7 million in women. This number is expected to increase to 24 million by 2035.

Papaya, a species of Carica Papaya, belonging to the family Caricaceae, native to the tropics of the Americas.

The fruit has been used in traditional medicine as remedies for many various ailments, including gastric problems, inflammation, and cancer.

The major chemical constituents of papaya include ethanol extract including benzylisothiocyanate are said to exhibit immunomodulatory, anti-inflammatory, antihyperlipidemic, anti cellular oxidative stress, anti neural tube defect, etc. effects.

Aqueous extract, according to University of Tokyo, on various tumor cell lines, showed to inhibit significant growth activity, through immunomodulatory effects including, interleukin 12 (also known as natural killer cell stimulatory factor 2), IL-12p70(a heterodimer), IFN-gamma(regulation of immunologically relevant genes) and TNF-alpha(innate immune response against pathogenic infection).

Fermented papaya, a traditional dish of many Southeast Asian cultures, processed antioxidan, and immune-modulating potentials, through the influence of signaling cascades associated with cell growth and survival, from epidemiological and in-vitro studies of patients with diabetes.

 In Azoxymethane (AOM) induced colon cancer in rats, papaya peel extract (PapPE), showed a significantly ameliorated the cytotoxic effects of AOM, through the potent antioxidant activities in the reduction of oxidative stress (glutathione depletion, lipid peroxidation).

In cultured human lung cancer H69 cell, Benzyl glucosinolate (BG) found in the pulp and the seed of papaya, inhibited cancer cell proliferation at a dose of 6.5 μmol, probably through its effect in superoxide generation and apoptosis induction.

Benzylisothiocyanate (BITC), another chemical constituent also mediated apoptosis of prostate and pancreases cancer cells through activation of both procaspase-8 pathways(initiation of apoptosis) and cell cycle arrest, inhibition of the advanced ovarian cancer cell lines through activation of caspase-3(activation in the apoptotic cell) and -9(activation of apoptotic process), and cleavage of PARP-1(repair of DNA damage) and breast cancer through generation of reactive oxygen species.

Dr/ Nguyen and the research team at The University of Queensland told PubMed "(The) extract-based or specific compound-based investigations and emphasize the aspects (of papaya) that warrant future research to explore the bioactives in C. papaya for their anticancer activities".

Taken altogether, fermented papaya containing major chemical constituents such as Benzyl glucosinolate (BG) and Benzylisothiocyanate (BITC) may be considered a functional food for the prevention and an adjunct therapy combined with the conventional medicine for the treatment of cancers, but further studies with large sample size and multi-centers are necessary to reaffirm papaya anti cancers possibility.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) #Healthy #Foods - Fruits - Papaya (Carica Papaya)(Better living and living health)
(2) Anticancer activity of Carica papaya: a review by Nguyen TT1, Shaw PN, Parat MO, Hewavitharana AK. (PubMed)
(3) Cancer statistics Worldwide(World center fund International)
(4) Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects by Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C.(PubMed)
(5) Diabetes as a risk factor to cancer: Functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer by Aruoma OI, Somanah J, Bourdon E, Rondeau P, Bahorun T. (PubMed)
(6) Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts by Waly MI, Al-Rawahi AS, Al Riyami M, Al-Kindi MA, Al-Issaei HK, Farooq SA, Al-Alawi A, Rahman MS.(PubMed)
(7) Content determination of benzyl glucosinolate and anti-cancer activity of its hydrolysis product in Carica papaya L, by Li ZY1, Wang Y, Shen WT, Zhou P.(PubMed)
(8) Papaya seed represents a rich source of biologically active isothiocyanate by Nakamura Y, Yoshimoto M, Murata Y, Shimoishi Y, Asai Y, Park EY, Sato K, Nakamura Y. (PubMed)
(9) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(10) Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro by Kalkunte S, Swamy N, Dizon DS, Brard L(PubMed)
(11) Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak by Xiao D1, Vogel V, Singh SV. (PubMed)
(12) Ficus carica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities by Mawa S, Husain K, Jantan I.(PubMed)

Herbal Butterbur, the Potent Anti Seasonal Allergic Rhinitis Functional Herb, Scientists Suggest

By Kyle J. Norton

Herbal Butterbur may be considered an adjunct therapy for the prevention and treatment of seasonal allergic rhinitis, some scientists suggested.

Seasonal allergic rhinitis is a condition of inflammation of the nasal passages as a result of seasonal allergic effects.

Most cases of rhinitis are caused by the immune system overreaction of pollen, mold, animal dander, or dust, the body releases chemicals.

Most people with acute allergic rhinitis are experiencing symptoms of sneezing, itchiness and a blocked or a runny nose.

However, some people may have chronic allergic rhinitis,  because they're sensitive to all seasonal allergens, including tree or grass pollen.

Most acute allergic rhinitis does not require medical attention, however, if your acute allergic rhinitis that lasts for several months and disrupts your daily activity, you may want to check with your doctor to rule out other possibilities.

Longterm untreated allergic rhinitis may induce complications of nasal polyps, sinusitis, and middle ear infections.  

Most cases of allergic rhinitis can be treated with over counter medicine, including non-sedating antihistamines and nasal passages spray with a salt water solution.

In a severe case, a stronger medication, such as a nasal spray containing corticosteroids can be helpful.

Please make sure that you know all the side effects of corticosteroids for preventive measure.

Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The plant has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.

The Chemical ingredients of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

In the study to re-examine the recent literature regarding the alternative therapies for the treatment of allergic rhinitis, Dr. Man LX, at the University of Pittsburgh School of Medicine, found that although there are several studies report beneficial effects of Butterbur for treating allergic rhinitis. additional insight into the mechanisms of action, short-term and long-term effects and adverse events are necessary before the herbal medicine can be integrated into the general treatment armamentarium of allergic rhinitis.

Dr. Guo R, the lead author in the study to investigate the efficacy of herbal medicines for the treatment of allergic rhinitis (AR) launched a search in the 5 electronic databases published before and on November 8, 2005.

The guideline and criteria were set to only include double-blind randomized clinical trials (RCTs), which tested a herbal medicine against placebo or an active comparator, in patients with AR, and evaluated clinically relevant outcomes.

Study selection, data extraction, and evaluation of methodological quality were performed independently by 2 reviewers.

16 eligible RCTs, testing 10 different herbal products against placebo or an active comparator, were included.

Out of 16 selected studies, Six RCTs studied suggested that Petasites hybridus (butterbur) extract is superior to placebo or similarly effective compared with nonsedative antihistamines for intermittent AR.

At the final report of the study, the doctors wrote, "There is encouraging evidence suggesting that P hybridus may be an effective herbal treatment for seasonal (intermittent) AR".

These results suggested that herbal Butterbur may be considered a functional herb for the prevention and treatment of seasonal allergic rhinitis without inducing serious side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Conventional, complementary, and alternative options for seasonal allergies by Moyad MA. (PubMed)
(2) Complementary and alternative medicine for allergic rhinitis by Man LX. (PubMed)
(3) Herbal medicines for the treatment of allergic rhinitis: a systematic review by Guo R, Pittler MH, Ernst E.(PubMed)

Strawberries, The Functional Food Which Inhibits the Risk Factors of the Onset of Atherosclerosis, Researchers Suggest

By Kyle J. Norton

Strawberries may be considered a functional food that blocks the plaque accumulated in the arteries, causing atherosclerosis, some scientists suggested.

Atherosclerosis is a medical condition of heart disease characterized by plaque building up in the inner wall of the arteries.

Where arteries are blood vessels that carry oxygen and nutrient-rich blood to the heart and other organs and tissue of the body and plaque is the substance made up mostly with fat, cholesterol, calcium.

According to the statistics, atherosclerosis causes 32% of deaths of heart disease. The prevalent rate of the disease onset among adults of 20 years and above is 13.8%.

Dr. Singh RB, the lead author in the assessment of diet and exercise and lifestyle on risk of atherosclerosis conducted a randomized, single-blind, controlled trial, 621 patients assigned either intervention diet A (group A, 310 patients) or control diet B (group B, 311 patients) for a period of 24 weeks.

Where participants of group A are received: (1) a diet with a higher percentage of calories from fruits and vegetables and complex carbohydrates; (2) a higher polyunsaturated/saturated fat ratio diet; and (3) a larger amount of soluble dietary fiber, antioxidant vitamins and minerals and low saturated fat and cholesterol than group fB. Group A patients also did more physical and yogic exercises than group B.

After 24 weeks of intervention, he wrote. " There was a significant decrease in serum total cholesterol (13.3%), low-density lipoprotein cholesterol (16.9%), triglycerides (19.2%), fasting blood glucose (19.5%) and blood pressures (11.5/6.2 mm Hg) in the intervention group compared with initial levels and changes in group B".

These result suggested that a healthy diet accompanied by moderate exercise are the major factors that can substantially reduce the risk of atherosclerosis. In other words, people who follow the Western diet with physical inactivity are at higher risk to the onset of the disease.

Strawberries are a genius of Fragaria × ananassa belonging to the family Roseaceae.

They have been grown all over the world in a suitable climate for commercial profits and health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Intake of strawberry daily to improve the potent antioxidants status in the body can reduce cardiovascular risk factors, such as elevated blood pressure, hyperglycemia, dyslipidemia, and inflammation in limited studies.

Dr. Basu A, the team leader at the Oklahoma State University, Stillwater study showed that freeze-dried strawberry supplementation improves blood pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome, thereby lowering cardiovascular risk factors in these subjects suggested.

The randomized controlled trial included 27 subjects with metabolic syndrome (2 males and 25 females; body mass index, 37.5 +/- 2.15 kg/m(2); age, 47.0 +/- 3.0 years [means +/- SE]) consumed 4 cups of freeze-dried strawberry beverage (50 g freeze-dried strawberries approximately 3 cups fresh strawberries) or equivalent amounts of fluids (controls, 4 cups of water) daily for 8 weeks.

Strawberry supplementation intake significantly decreased total and low-density lipoprotein cholesterol (5.8 +/- 0.2 to 5.2 +/- 0.2 mmol/L and 3.5 +/- 0.2 to 3.1 +/- 0.1 mmol/L, respectively [means +/- SE], P < .05) and low-density lipoprotein particles compared to controls at the week 8.

Furthermore, strawberry supplementation also decreased circulating levels of vascular cell adhesion molecule-1 vs controls at the end of the study.

The team at the final report said, "short-term freeze-dried strawberry supplementation improved selected atherosclerotic risk factors, including dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome".

In additional examing the therapeutic roles of strawberries, blueberries, and cranberries in metabolic syndrome, a prediabetic state characterized by several cardiovascular risk factors, Dr. Basu A said, "strawberries lowering total and LDL-cholesterol, but not triglycerides, and decreasing surrogate biomarkers of atherosclerosis (malondialdehyde and adhesion molecules)".

Strawberry also extended a lowering systolic and diastolic blood pressure and lipid oxidation and improving insulin resistance but in the lesser effect compared to the blueberry

Cranberry juice selectively decreasing biomarkers of lipid oxidation (oxidized LDL) and inflammation (adhesion molecules) in metabolic syndrome compared to lesser effect in those of strawberry.

The tested berries demonstrated a potential effect in up-regulation of endothelial nitric oxide synthase activity in the protection of the cardiovascular system, reduction of renal oxidative damage, and inhibition of the activity of carbohydrate digestive enzymes or angiotensin-converting enzyme in controling the blood pressure by regulating the volume of fluids in the blood.

Taken all together, strawberry may be considered a function\al food for the prevention of atherosclerosis and combined with the primary therapy for the treatment of the disease.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Reference
(1) The strawberry: composition, nutritional quality, and impact on human health. by Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M.(PubMed)
(2) Phenolic Composition of Strawberry Genotypes at Different Maturation Stages(ACS Publication)
(3) Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.
Basu A, Fu DX, Wilkinson M, Simmons B, Wu M, Betts NM, Du M, Lyons TJ.(PubMed)
(4) Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives.
Basu A, Lyons TJ.(PubMed)
(5) Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study by Singh RB1, Singh NK, Rastogi SS, Mani UV, Niaz MA. (PubMed)

Dried Pea, The Legume Which May Process Anti Colon Cancer Potency

By Kyle J. Norton

Dried peas with high of fiber may have a potential effect in the prevention and treatment of colon cancer.

Colon cancer is a chronic and medical condition characterized by cells growth uncontrollably and disorderly that start on the surface of the inner lining of colon tissue.

At the advanced stage, the cancerous cell can travel a distance away from the original site to affect other healthy tissue and organ through the circulation of blood and fluids.

The exact causes of colon cancer are unknown. However, researchers do know that unhealthy diet and lifestyle with physical inactivity are associated with a substantially increased risk of colon cancer.

Epidemiological studies agreed that the Western diet is associated with the increased risk and recurrent risk of colon cancer.

Ms. Marilisa Racco at the National Online Journalist, Smart Living Global News wrote "There’s more bad news for lovers of red meat and refined grains — also known as a Western diet — from cancer researchers. A new study has found that a pro-inflammatory diet that’s heavy in processed red and organ meat, refined grains, and sugary drinks, will significantly increase the risk of developing colorectal cancer in both men and women".

Furthermore, a higher intake of a Western dietary pattern after cancer diagnosis was also associated with recurrence and death in colon cancer patients.

Publish on the Public Medical Literature, the study includes a total of 1009 patients with stage III colon cancer.

Researchers said, "During a median follow-up of 5.3 years for the overall cohort, 324 patients had a cancer recurrence, 223 patients died with cancer recurrence, and 28 died without documented cancer recurrence".

These result suggested that genetic preposition and an unhealthy diet and lifestyle the major risk factors that associate to the onset of colon cancer and recurrent colon cancer.

Dried peas are the small but nutritionally mighty member of the legume family, the genus Pisum belonging to the family Fabaceae.

The bean has a healthy source of protein, fibers, vitamins, and minerals that are good for everyone diet.

Besides it main component of the polyphenolic compound, dried bean also contains saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols, cerebroside, etc.

In the study to reaffirm the polyphenolics and saponins effect in the stimulation of antioxidant enzymes in the host and anticarcinogenic activity, researchers launched an investigation to examine the naturally occurring plant protease inhibitors which have potential health-promoting properties within the mammalian gastrointestinal tract against the risk of colon cancer.

Bowman-Birk inhibitors (BBI) isolated from peas exerts anti-carcinogenic and anti-inflammatory properties in the large intestine by surviving from both acidic conditions and the action of proteolytic enzymes in the stomach and small intestine,

A recombinant form of TI1B (rTI1B), representing a major BBI isoinhibitor from pea also inhibited the growth of human colorectal HT29 cells in vitro.

The proliferation of HT29 colon cancer cells was significantly affected by the injection of rTI1B in a dose-dependent manner (IC50 = 31 (sd 7) μm), compared to the novel engineered mutant.

Interestingly, application of  rTI1B induced HT29 colon cancer cells apoptosis without affecting the nearby healthy cells.

Furthermore, the rTI1B proved to be active against trypsin and chymotrypsin in facilitating the colorectal carcinogenesis and promotes proliferation, invasion, and metastasis.

Proteases inhibitor isolated from the peas may process a potential chemopreventive effect during the early stages of colorectal carcinogenesis.

Adding 1 or 2 portions of dried peas into a daily diet in high colon cancer risk patients may reduce the incidence of colon cancer.

Taken all together, dried peas may be considered a function legume in the prevention and an adjunct therapy for the treatment of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the dried peas or its bioactive compounds during the course of the disease will be necessary to complete the picture of its anti-colon cancer possibilities.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Review of the health benefits of peas (Pisum sativum L. by Dahl WJ, Foster LM, Tyler RT. (PubMed)
(2) The anti-proliferative effect of TI1B, a major Bowman-Birk isoinhibitor from pea (Pisum sativum L.), on HT29 colon cancer cells is mediated through protease inhibition by Clemente A, Carmen Marín-Manzano M, Jiménez E, Carmen Arques M, Domoney C.(PubMed)
(3) Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer by Meyerhardt JA1, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS. (PubMed)

Avocado, the Fruit Which Kills Breast Cancer Cells in Vivo and Vitro, Scientists Say

By Kyle J, Norton

Avocado may be considered a potentially functional fruit for the prevention and treatment of breast cancer, some scientists suggested.

Breast cancer is the medical condition that starts on the surface of the inner lining of breast tissue in the early stage. On this stage, a small lump may be found when touched.

The 5 years survival rate at this stage is 100%.

However, at the later stage, malignant cancers cell can travel a distance away from the original site to infect other healthy tissue and organs.

The lifetime risk for a woman to develop breast cancer is 1/8 in the US.

The epidemiological studies suggested that women who carry the mutated gene BRAC1 and 2 are associated with substantially increased risk of the disease onset.

Men who carry the mutated gene BRCA2 have a 7% lifetime risk of developing breast cancer.

Sadly, women who carry the abnormal BRCA1 orBRCA2 gene have about a 60% risk of being diagnosed with breast cancer during their lifetimes, compared to only 12.5%  for other women.

In a comment of the study published on June 20 in the Journal of the American Medical Association Dr. García-Closas, M.D., Dr.P.H., deputy director of NCI's Division of Cancer Epidemiology and Genetics, who was not involved in the research. said, “This study has confirmed estimates of the risk of developing cancer for women who are mutation carriers—that confirmation is reassuring for both women and the healthcare team who make important care decisions.”

Therefore, suggestions to these women may include intensive early surveillance, use of chemoprevention, and prophylactic surgery may be necessary for the prevention and treatment of breast cancer.

Avocados are a commercially valuable fruit and are cultivated in tropical climates throughout the world, it is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Chemical constituents of avocado include
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B.

Persin, the toxic chemical compound found in the fruits and leaves of avocado inhibited human breast cancer cell line, in the testing of synthetic analogs of the avocado-produced toxin persin by activated the program cells death pathway.

When using combined with tamoxifen, the small amounts of tamoxifen needed to perform similar chemo effects, thus reducing the toxicity to the healthy cells that normally killed by the presence of tamoxifen.

Futhermore, in the study to examine the anticancer properties of Persea declinata (Bl.) Kosterm bark methanolic crude extract (PDM), researchers at the University of Malaya launched an investigation to test the PDM in the exhibition of antiproliferative effect in MCF-7 human breast cancer cells.

Application of the PDM exhibited a potent antiproliferative effect in MCF-7 human breast cancer cells, with an IC50 value of 16.68 µg/mL after 48 h of treatment.

Injection of PDM caused cell cycle arrest and subsequent apoptosis in MCF-7 cells, as seen by increase population at the G0/G1 phase and, higher lactate dehydrogenase (LDH) release, and DNA fragmentation, the indications of cancer cells apoptosis.

Additional analysis suggested that PDM elevated the expression of ROS in the induction of cancer cell death through cytotoxicity observed by the perturbation of mitochondrial membrane potential, cell permeability, and activation of caspases-3/7, in the execution phase of apoptosis. 

The results of cancer cells apoptosis can be observed through the increased the expression of the proapoptotic molecule, Bax, but decreased the expression of prosurvival proteins, Bcl-2 and Bcl-xL, in a dose-dependent manner after PDM administration.

The finding strongly suggested that PDM isolated from avocado could inhibit proliferation in MCF-7 cells via cell cycle arrest and apoptosis induction.

Taken altogether, avocado may be considered a functional fruit for the prevention and an adjunct therapy combined with conventional medicine for the treatment of breast cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of the avocado anti-breast cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Leung's Encyclopedia of Natural Ingredients: Chemical Composition of Avocado
(1) Synthesis and in vitro evaluation of analogs of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG1, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ. (PubMed)
(2) Persin - the avocado toxin that kills breast cancer cells(Gavan Institution)
(3) Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation by Narrima P1, Paydar M1, Looi CY1, Wong YL1, Taha H2, Wong WF3, Ali Mohd M1, Hadi AH(PubMed).