Asparagus, The Veggie Which Causes Cytotoxicity on Cancers

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole food with the potential to kill cancer cells before they can cause some serious effect on the human body, some studies suggested.

Cancer is the group of diseases characterized by cell growth disorderly and uncontrollably in some tissue and organs, due to the alternation of cell DNA.

At the advanced stage, most invasive cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs through the circulation of blood and fluid.

The causes of cancer are unknown, researchers do not why people with the same health conditions and family history, some are susceptible to the onset of the diseases while others do not.

However, they do know that smoking, radiation, viruses, cancer-causing chemicals (carcinogens), obesity, hormones, chronic inflammation and a lack of exercise are most risk factors associated to the early onset of cancers.

Furthermore, genes mutation such as BRCA1 and 2 inherited from the parents are one of the major risk factors that cause cancers.

Long-term excessive alcohol drinking is associated with a higher risk of liver cancer.

According to the World Cancer Research Fund, Eating 'fast foods' (such as chips and fried chicken) or other processed foods that are high in fat and sugar (like chocolate, crisps, and biscuits) can make you gain weight, and there is strong evidence that being overweight or obese is a cause of 12 types of cancer. And diets that are high in plant foods – such as fruit, vegetables, whole grains, and beans – can help you stay a healthy weight, and may also protect against certain cancers.

Moreover, Dr. Weiderpass E, in the study of "Lifestyle and cancer risk" wrote. "The main behavioral and environmental risk factors for cancer mortality in the world are related to diet and physical inactivity, use of addictive substances, sexual, and reproductive health, exposure to air pollution and use of contaminated needles".

Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.

Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

Its chemical constituents include essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin.


In the study of saponins from old stems of asparagus (SSA) potential inhibitory activity on tumor growth and metastasis conducted by the East China Normal University on the breast, colon and pancreatic cancer cell lines, researchers found that
* Injection of saponins displays a significant effect in the inhibition of all tested cancer cell lines in a concentration-dependent manner, with half-maximum inhibitory concentrations ranging from 809.42 to 1829.96 µg mL(-1).

* At the concentration of 400 µg mL(-1), SSA is more functional in blocking cell migration and invasion as compared with its cytotoxic effect.

* Furthermore, SSA markedly increased the activities of Cdc42, a protein with function involved in the regulation of the cell cycle. and Rac1 with function in stimulating the cytotoxicity activity and decreased the activity of RhoA that is associated with cytoskeleton regulation, in cancer cells.

These results suggested that SSA increased the levels and activities of reactive oxygen species in exerting cytotoxicity against the proliferation and migration of cancer cells.

Dr.Wang J, the lead scientist at the final report, said, "SSA inhibits tumor cell motility through modulating the Rho GTPase signaling pathway (in the regulation of diverse cellular functions), suggesting a promising use of SSA as a supplement in healthcare foods and natural drugs for cancer prevention and treatment".

Moreover, in the examine the function of a series of Sarsapogenin and Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum and Asparagus racemosus against cancers, researchers showed that the isolated compounds exert their ability to induce cell death and apoptosis of colon carcinoma cells. 

The carbohydrate moieties linked to the steroid backbones process the strong influence in the induction of cytotoxic activity and cell death mode (apoptosis or necrosis). 

Taken all together, asparagus containing high amounts of saponins and newly Sarsapogenin and Diosgenin derived steroidal constituents may be considered a functional food for the prevention and treatment of cancers.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Chemical constituents of Asparagus J. S. Negi, P. Singh, [...], and V. K. Bisht (PubMed)
(2) Saponins extracted from by-product of Asparagus officinalis L. suppress tumor cell migration and invasion through targeting Rho GTPase signaling pathway. by Wang J, Liu Y, Zhao J, Zhang W, Pang X.(PubMed)
(3) Apoptosis-inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus. by Bhutani KK, Paul AT, Fayad W, Linder S.(PubMed)

Green Tea Protects the Child Joints Against the Onset of Juvenile Arthritis

By Kyle J. Norton, Master of Nutrition


Green tea may have a therapeutic and positive effect in reducing risk, progression, and treatment of juvenile arthritis, some scientists suggested.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Juvenile Arthritis shares the common symptoms of adult arthritis, including pain, stiffness, swelling, fever, skin rash and in the serious case. The condition can also cause some complications such as pericarditis, hemolytic anemia, macrophage activation syndrome (MAS), and endarteritis

In the article "Juvenile Arthritis: Early Signs and Symptoms" By Susan Bernstein wrote, "Juvenile arthritis includes many different diseases, but one common thread between them is that they can have serious, even life-threatening impacts on a young child".
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

In the investigation of the effect of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, a model for human rheumatoid arthritis with daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days, researchers at the State University of Maringá, found that treatment group expressed a significant activity in reducing the protein and lipid damage in liver, brain, and plasma, caused by ROS expression in induction of oxidation which has been found with associated to the progression of arthritis.

Injection of green tea extract also enhanced the overexpression of antioxidant defenses, found in low levels in patients with arthritis through restoration of the glutathione (GSH) associated to the important function in preventing damage to important cellular components caused by reactive oxygen species and protein thiol levels in reducing cellular oxidation through chelative and detoxified activities and improved natural antioxidant enzymes, produced by the body.

Furthermore, green tea extract also inhibited the levels of glucose 6-phosphate dehydrogenase, which is increased in the liver in patients with arthritis, one of the major risk factor for the development of arthritis.

These results suggested that application of green tea exerted a significantly profound effect in the liver and brain of patients suffering from rheumatoid arthritis through reduced overexpression of oxidative stress in precipitated injury to lipids and proteins.

Some researchers suggested that by modifying the metabolic function in lipid and protein, green tea extract exhibited a strong protective effect in reducing the symptoms and progression of arthritis.

According to the study of University of Health System of green tea effect in patients with rheumatoid
arthritis, injection of green tea extract demonstrated a therapeutic effect in patient's synovial fibroblast of the lining tissue which surround the capsule of the joint by inhibiting the production of IL-1B, a prototypic proinflammatory cytokines in response to acute and chronic inflammation. Overexpression of IL-1B is associated with the contribution of joint damage.

Interestingly, in the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), researchers indicated that application of tea significant inhibits the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.

Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.

Due to the limitation of the study, Dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".

More importantly, in the examine some major factors in contributing juvenile arthritis, green tea rich in catechins (Healthy green tea) in animal study, green tea injection restored these biomarkers of cytokine genes (IL-1A, IL-2, IFN-alpha, FGF-alpha, TNF-alpha) to near normal levels, thus preventing or attenuating the development of a certain type of inflammatory arthritis.


Taken all together, green tea and its bioactive polyphenols may be considered a functional food for reduction of the early onset, progression and combined with standard therapy for treatment of juvenile and adult arthritis.

However, the intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM. (PubMed)
(2) (Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(3) Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver by Abe K1, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M.(PubMed)

Caffeinated Coffee, the Beverage Which Processes anti Hepatic Fibrosis Potency

By Kyle J. Norton, Master of Nutrition


Intake of coffee daily and regularly may be considered a functional beverage in blocking the onset and treating liver fibrosis, some scientist suggested.

Hepatic fibrosis is a condition characterized by overly exuberant wound healing causing excessive connective tissue builds up in the liver. In other words, hepatic fibrosis is a portion of the liver which was affected by scars formation.

The exact causes of liver fibrosis are unknown. However, certain risk factor such as repeated liver injury caused by virus infection, and a blockage in the bile ducts are found to elaborate the onset of liver fibrosis.

Long-term untreated liver fibrosis can lead to cirrhosis, a condition of the severe scarring of the liver and life-threatening liver disease.

The most common scale to grade the stage of liver fibrosis is the METAVIR scoring system. By examing the grade and stage of liver fibrosis of patients, their doctors can now determine the degree of severity to which patients liver is affected.

The severity of the grades range from A0 to A3:
A0: no activity
A1: mild activity
A2: moderate activity
A3: severe activity

and 

The severity of fibrosis stages range from F0 to F4:
F0: no fibrosis
F1: portal fibrosis without septa
F2: portal fibrosis with few septa
F3: numerous septa without cirrhosis
F4: cirrhosis, the most severe stage  of fibrosis

Coffee, the best popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In the examine 910 patients with chronic HCV infection, 98% male and 38% with advanced hepatic fibrosis, researchers filed the following results
* Intake of coffee is lower in the control group, compared to the advanced fibrosis.

* But caffeine intake of higher than 100 mg or more, daily from all sources was found in controls (66.0%) than patients with advanced fibrosis (57.9%).

* Caffeine intake of controls mostly come from the coffee intake.

*  Intake of average daily of 100 mg or more of caffeine (adjusted odds ratio, 0.71; 95% confidence interval, 0.53-0.95; P = .020) was associated with the increased liver protective effect.

The result demonstrated that moderately coffee and coffee caffeine intake of 100 mg may have a protective benefit against the risk of advanced hepatic fibrosis.

Additionally, in the study, using food-frequency instrument for dietary caffeine consumption to evaluate the relationship between caffeine intake and liver fibrosis in patients undergoing liver biopsy completed a detailed caffeine questionnaire on three occasions over a 6-month period, researchers at the National Institutes of Health (NIH), reported the results as follow
1. Daily caffeine consumption of 308 mg = approximately 2.25 cups of coffee equivalents was associated with reduced liver fibrosis.

2. The protective association persisted without changing even after taking into account other factors,

3. Compared to coffee caffeine, other sources of caffeine showed an insignificant effect in decreasing the risk of liver fibrosis.

After making the adjustment from all sources, Dr. Modi AA, the lead author said," A reliable tool for measurement of caffeine consumption demonstrated that caffeine consumption, particularly from regular coffee, above a threshold of approximately 2 coffee-cup equivalents per day, was associated with less severe hepatic fibrosis."

Promisingly, in the study of chronic HBV-infected patients underwent transient elastography examination in 2006-2008, questionnaire returned from among 1045 patients, 216 (20.7%) patients with advanced fibrosis., researchers also found the similar results, compared to other studies.

* The percentage of patients who drank ≥ 1 cup of coffee had advanced fibrosis was 95 (19.0%) , compared with 1.21 (22.2%) patients who drank < 1 cup (P = 0.21).

* Caffeine intake does not affect liver stiffness in chronic HBV-infected patients, compared to the coffee intake

Taking together, there is no doubt that coffee intake may have a profound effect in ameliorating the risk of hepatic fibrosis and advanced hepatic fibrosis regardless amount intake daily.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C by Khalaf N1, White D1, Kanwal F1, Ramsey D1, Mittal S1, Tavakoli-Tabasi S2, Kuzniarek J3, El-Serag HB4. (PubMed)
(2) Increased caffeine consumption is associated with reduced hepatic fibrosis by Modi AA1, Feld JJ, Park Y, Kleiner DE, Everhart JE, Liang TJ, Hoofnagle JH. (PubMed)
(3) The effect of caffeine and alcohol consumption on liver fibrosis - a study of 1045 Asian hepatitis B patients using transient elastography by Ong A1, Wong VW, Wong GL, Chan HL. (PubMed)

Strawberries, the Fruits That Kill 100% of Breast Cancer Cells in Vivo and Vitro, Scientists Say

By Kyle J. Norton, Master of Nutrition


Breast cancer (malignant breast neoplasm) is a type of irregular cell growth that starts either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk in the breast.

There are also rare cases, that breast cancer starts in other areas of the breast.

 In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone. The risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

The causes of breast cancer are unknown. Researchers do not know, people with the same health conditions and similar family history, some are more susceptible to the onset of the disease, while others do not.

However, an increase of aging, history with breast conditions, such as previous breast cancer, breast density, use of hormone estrogen therapy, overweight and obese and excessive alcohol consumption are some major risk factors which can elevate the development of breast cancer.

Furthermore, genetic mutation of certain inherited from the parent such as gene BRCA1 and BRCA2 are also the prevalent risk factors of breast cancer. There is an estimation that 33% of women who carry a harmful mutation in PALB2 will develop breast cancer by age 70 years.

According to the article posted by the National Institute of Health, " Several different tests are available. Some tests look for a specific harmful BRCA1 orBRCA2 gene mutation that has already been identified in another family member. Other tests check for all of the known harmful mutations in both genes. Multigene (panel) testing uses next-generation sequencing to look for harmful mutations in many genes that are associated with an increased risk of breast and ovarian cancer, including BRCA1 and BRCA2, at the same time".

If you have a family history of genetic mutation involved breast cancer, please make sure that you have them checked to rule out the possibility.

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae.

The fruit has been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

Epidemiological studies strong agree that consumption of berry fruits, including strawberries have beneficial effects on human health and reduce the risk of chronic diseases, including breast cancer.

According to the Indian Institute of Science which conducted the experiment to examine whether a methanolic extract of strawberry (MESB) fruits processes anticancer activity in leukemia (CEM) and breast cancer (T47D) cell lines ex vivo, and its cancer therapeutic and chemopreventive potential in mice models, 

*  Mice bearing breast adenocarcinoma with MESB treated by the extract blocked the proliferation of tumor cells in a time-dependent manner.

* Application of the extract also increases lifespan in the cancer-bearing animal model.

* MESB treatment affected tumor cell proliferation by activating apoptosis and did not result in any side effects

* Finally, MESB treatment also induce intrinsic pathway of apoptosis by activating p73 in breast cancer cells, caused by the mutation of tumor suppressor gene p53.

These results revealed that strawberry fruits possess both cancer preventive and therapeutic values. 

Additionally, in the study to test for anti-breast cancer activity in extracts of six popularly consumed berries--blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry conducted by the University of California, researchers found that strawberry and other berry extracts exert their ability to inhibit the growth of human breast cancer cell line MCF-7 at concentrations ranging from 25 to 200 micro g/mL.

Moreover, researchers also discovered the apoptosis rate of breast cancer cells killing are increased with increasing concentration of the extract. These findings suggested that strawberry extract may have a potential to kill 100% of the breast cancer cells in a dose-dependent manner.

In compared to other extracts, black raspberry and strawberry extracts showed the most significant pro-apoptotic effects against breast cell line.

However, due to the limitation of the above studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of strawberry anti-breast cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice, by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)

Maternal Coffee > 4 Cups/day or Coffee Caffeine > 2 Cups/day Intake in the Increased Risk of Spontaneous Abortion (SAB)

By Kyle J. Norton, Master of Nutrition

Risk of spontaneous abortion (SAB) is increased substantially in the excessive coffee women during pregnancy, some studies suggested.

Spontaneous abortion is a clinically recognized pregnancy loss within the 20 weeks of gestation.

According to the World Organization of Health, fetus expulsion or extraction, weighing 500 g or less. are considered spontaneous abortion.

Believe or not, spontaneous abortion happens quite common in the early stage of pregnancy and the risk is decreased substantially with increasing gestational age.

Genetically, the causes of spontaneous abortion (SAB) are associated with mutation of genes inherited from the parents. researchers found that genes that cause the alternation of intrauterine fetal demise, blighted ovum, partial and molar pregnancy are the most common forms of spontaneous abortion.

Externally, maternal age, poor diet, excessive use of alcohol, smoking, untreated thyroid disease uncontrolled diabetes, use of certain medication and the physical problem with reproductive organs are associated with a significant risk of the incidence.

Furthermore, women who have a family history and previous miscarriage are also at the higher risk of the onset of spontaneous abortion (SAB).

Coffee, one of the most popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In a case-controlled study conducted in Milan of 561 (72%) cases of spontaneous abortion and 877 (57%) controls, coffee drinking during the first trimester of the index pregnancy with healthy women who gave birth at term (> 37 weeks gestation) to healthy infants as control, researchers found that
* Coffee intake of 1, 2 or 3, and 4 or more cups of coffee per day, are associated to increase the risk of 1.2, 1.8 and 4.0, respectively in compared to nondrinkers.

* The risk of pregnancy loss also is associated to the duration in years of coffee drinking. The estimated multivariate odds ratios of spontaneous abortion were 1.1 compared to non-coffee intake group.

Furthermore, in the evaluated effect of caffeine in influence of miscarriage researchers at the Boston University School of Public Health, conducted a prospective cohort study included 5132 Danish women planning pregnancy, enrolled from 2007 to 2010, after carefully assessing the returned beverage consumption on questionnaires, researcher found that  spontaneous abortion (SAB) is 1.62 higher in women consumed more than 300 mg/day of caffeine per day, in compared to 1.09 in women who consume <100 mg/day.

Specifically, women with daily intake of caffeine of
*  <100 mg/day showed a materially associated with SAB risk of 1.09.

* 100-199mg/day showed a materially associated with SAB risk of 0,89.

* 200-299mg/day showed a materially associated with SAB risk of 1.33.


Interestingly, in prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009) with beverage intake assessed every 4 years using a validated questionnaire in case pregnancies lost spontaneously at <20 weeks gestation, total coffee intake had a positive, linear association with SAB.

Compared to non-pre-pregnancy coffee intake, the risk of SAB increased by 20% for women consuming ≥4 servings/day.

More importantly, Dr. Gaskins AJ, the lead author said, "Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with increased risk of SAB, particularly at weeks 8-19".


Taking together, there is no doubt that caffeinated coffee may contribute to a relative risk of spontaneous abortion (SAB) for women consuming more than 4 cups per day.

Women who are pregnant between 12 to 20 weeks of gestation with excessive coffee intake habit are recommended to consult with their doctors.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation by Parazzini F1, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G, Fedele L, Benzi G.(PubMed)
(2) Caffeine and caffeinated beverage consumption and risk of spontaneous abortion by Hahn KA1, Wise LA2, Rothman KJ3, Mikkelsen EM4, Brogly SB5, Sørensen HT6, Riis AH4, Hatch EE5.(PubMed)
(3) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion by Gaskins AJ1,2, Rich-Edwards JW3,4,5, Williams PL3,6, Toth TL7, Missmer SA3,4,8,9, Chavarro JE10,3,4.(PubMed)

Green Tea, The Beverage Inhibits The Excessive Uric Acid That Cause Acute and Chronic Gout

By Kyle J. Norton, Master of Nutrition


Green tea may have a therapeutic and positive effect in blocking the onset and treatment of gout and recurrent gout, some scientists suggested.

Gout is a condition of recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by overexpression of purine in the body.

Gout is caused by an excess of uric acid in the blood, or hyperuricemia. Uric acid is a by-product that is produced during the digestive process in the breaking down of chemical ingredients purines.

Purines are natural nitrogen-containing compounds found in the cell DNA and RNA, including adenine (6-aminopurine) and guanine (2-amino, 6-oxypurine), is made inside the cells of the body.

exogenously, purines can come from foods containing purine.

Under normal condition, uric acid is eliminated by the kidney through urination. However, a high uric acid level can occur when the kidneys don't eliminate uric acid efficiently.  People with kidney deficiency are associated with high levels of uric acid if foods with high levels of purines are consumed in a large amount, including red meat, seafood, and mushroom.

Some researchers suggested that people who are obese, overweight with diabetes, long-term use of diuretics and excessive alcohol drinking are associated with the risk of high levels of uric acid in the blood.

Additionally, genetic mutation inherited from the parents such as Q141K polymorphism and CFTR ΔF508 certain medical conditions such as tumor lysis syndrome, hypothyroidism, and psoriasis are also some major risk factors to cause excessive levels of uric acid in the blood.

If you are currently taking long-term medications as maintenance therapy, to keep uric acid levels steady. Please make sure that you are aware of their side effects.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

According to the joint study led by the University of Nagasaki, green tea and its bioactive compounds Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reducing the vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for the formation of gout through expression of levels of uric acid.

The study also emphasized that green tea with high levels of antioxidant and function in the stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in the induced production of inflammatory cytokines to facilitate symptoms of inflammation.

The above differentiation was supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received a subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.

Truly, the application green tea EGCG decreased expression of gouty arthritis caused by injection of MSU-induced neutrophil infiltration with a function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.

The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in activated inflammatory response to optimize healing and reduce injury to the body but the proteins have been found to cause severe damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.

Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patients of chronic inflammatory disease, without limiting the function of the mediators in protect the infectious site against pathogens invasion.

More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.

Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."

Additionally, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited an antioxidant effect in reducing the pronounce of oxidative stress by their antioxidant properties.

Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reducing reactive oxygen species in the initiation of  oxidative stress that facilitates the inflammatory symptoms.

Taken all together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset and combined with conventional medicine for the treatment of gout with no adverse effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2. (PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1. (PubMed)

Fennel, the Best Functional Food to Normalizes Your Blood Cholesterol Quickly With No Side Effects

By Kyle J. Norton, Master of Nutrition

Scientists may have found a natural whole food with the potential to treat hyperlipidemia without inducing any side effects, some studies suggested.

Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.

The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have found to increase blood cholesterol, long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.

The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".

Hyperlipidemia is a lifelong condition which is treatable. 

Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".

Therefore by changing the diet pattern and engaging regular physical exercise are the fundamental 

options that not only can prevent the onset of the condition, particularly in people who are at the higher risk of hyperlipidemia and also treat high blood cholesterol in patients who already have the condition.

Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The plant has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS.

In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339 induced hyperlipidemia in mice.

Mice treated with the extract at different doses displays a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.

Further analysis, the application also increased the levels of  HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively

According to the Mashhad University of Medical Sciences which also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.

Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.

At the end of 3 months, blood profiled withdrawn from the women suggested

* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.

* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.

Additional differentiation of the process of the double-blind, randomized and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.  

These results indicated that intake of foods for treatment of conditions or diseases must be on a long-term basis. The times of 3 months may be too short for foods to exert their potential effects.

Taken all together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats by Amin KA1, Nagy M(PubMed)