Green Tea, The Beverage Inhibits The Excessive Uric Acid That Cause Acute and Chronic Gout

By Kyle J. Norton, Master of Nutrition


Green tea may have a therapeutic and positive effect in blocking the onset and treatment of gout and recurrent gout, some scientists suggested.

Gout is a condition of recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by overexpression of purine in the body.

Gout is caused by an excess of uric acid in the blood, or hyperuricemia. Uric acid is a by-product that is produced during the digestive process in the breaking down of chemical ingredients purines.

Purines are natural nitrogen-containing compounds found in the cell DNA and RNA, including adenine (6-aminopurine) and guanine (2-amino, 6-oxypurine), is made inside the cells of the body.

exogenously, purines can come from foods containing purine.

Under normal condition, uric acid is eliminated by the kidney through urination. However, a high uric acid level can occur when the kidneys don't eliminate uric acid efficiently.  People with kidney deficiency are associated with high levels of uric acid if foods with high levels of purines are consumed in a large amount, including red meat, seafood, and mushroom.

Some researchers suggested that people who are obese, overweight with diabetes, long-term use of diuretics and excessive alcohol drinking are associated with the risk of high levels of uric acid in the blood.

Additionally, genetic mutation inherited from the parents such as Q141K polymorphism and CFTR ΔF508 certain medical conditions such as tumor lysis syndrome, hypothyroidism, and psoriasis are also some major risk factors to cause excessive levels of uric acid in the blood.

If you are currently taking long-term medications as maintenance therapy, to keep uric acid levels steady. Please make sure that you are aware of their side effects.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

According to the joint study led by the University of Nagasaki, green tea and its bioactive compounds Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reducing the vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for the formation of gout through expression of levels of uric acid.

The study also emphasized that green tea with high levels of antioxidant and function in the stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in the induced production of inflammatory cytokines to facilitate symptoms of inflammation.

The above differentiation was supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received a subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.

Truly, the application green tea EGCG decreased expression of gouty arthritis caused by injection of MSU-induced neutrophil infiltration with a function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.

The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in activated inflammatory response to optimize healing and reduce injury to the body but the proteins have been found to cause severe damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.

Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patients of chronic inflammatory disease, without limiting the function of the mediators in protect the infectious site against pathogens invasion.

More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.

Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."

Additionally, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited an antioxidant effect in reducing the pronounce of oxidative stress by their antioxidant properties.

Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reducing reactive oxygen species in the initiation of  oxidative stress that facilitates the inflammatory symptoms.

Taken all together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset and combined with conventional medicine for the treatment of gout with no adverse effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2. (PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1. (PubMed)

Fennel, the Best Functional Food to Normalizes Your Blood Cholesterol Quickly With No Side Effects

By Kyle J. Norton, Master of Nutrition

Scientists may have found a natural whole food with the potential to treat hyperlipidemia without inducing any side effects, some studies suggested.

Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.

The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have found to increase blood cholesterol, long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.

The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".

Hyperlipidemia is a lifelong condition which is treatable. 

Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".

Therefore by changing the diet pattern and engaging regular physical exercise are the fundamental 

options that not only can prevent the onset of the condition, particularly in people who are at the higher risk of hyperlipidemia and also treat high blood cholesterol in patients who already have the condition.

Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The plant has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS.

In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339 induced hyperlipidemia in mice.

Mice treated with the extract at different doses displays a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.

Further analysis, the application also increased the levels of  HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively

According to the Mashhad University of Medical Sciences which also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.

Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.

At the end of 3 months, blood profiled withdrawn from the women suggested

* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.

* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.

Additional differentiation of the process of the double-blind, randomized and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.  

These results indicated that intake of foods for treatment of conditions or diseases must be on a long-term basis. The times of 3 months may be too short for foods to exert their potential effects.

Taken all together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats by Amin KA1, Nagy M(PubMed)

Carrot, The Vegetable Which Promotes Weight Loss and Prevents the Onset of Obesity

Kyle J. Norton

Carrots may have a profound and positive effect in reducing weight loss in the obese population, some scientists suggested.

Weight loss is an intentional action referred by the medicine, health, or physical fitness communities as a reduction of the total body mass, including loss of fluid, body fat or adipose tissue or lean mass.

Obesity is a condition or disease characterized by extreme overweight. According to the Body Mass Index calculator, BMI between 25.0 to <30 is considered overweight and BMI of 30.0 or higher, is considered obese.

According to the National Institue of Health, obese people are associated with numbers of diseases and conditions, including diseases of coronary heart disease, type 2 diabetes, certain types of cancer, stroke, gallbladder disease, liver disease, certain types of respiratory disease and infertility and conditions of high blood pressure, high total cholesterol or high levels of triglycerides, sleep apnea and osteoarthritis. 

Most researchers agreed that obesity is caused by a genetic mutation inherited from the parents, a longterm unhealthy diet with consumption of high amounts of energy foods, particularly fat and sugars and physical inactivity.

Other causable factors also include certain medical conditions such as hypothyroidism and Cushing's syndrome and a long-term use of certain medication such as corticosteroids and antidepressant.

The general belief also suggested that some smokers may gain weight if they quit smoking.

According to the study conducted by the J University of Georgia, using a combined approach to promote nutrition and physical activity policies and practices in the early care and education may reduce the risk of child obesity.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

 Estrogen-deficient animals with diet-induced obesity were examined in the study by the Obesity/Diabetes Center, Asan, Korea using black carrots to test the mechanisms of the long-term consumption of unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) or Aspergillus oryzae (BCAO) in the prevention of menopausal symptoms including impaired energy, glucose and lipid metabolism 

During the experiment, ovariectomized (OVX) rats were fed four different high-fat diets containing 2 % dextrin (OVX-control), 2 % BC, 2 % BCLP, or 2 % BCAO for 12 weeks. Sham rats were fed high-fat diets containing 2 % dextrin.

Fat mass and weight gain in tested mice were lower in descending order of OVX-control > BC and BCLP > BCAO due to increased energy expenditure and fat oxidation.

BC, BCLP and especially BCAO all normalized HOMA-IR, an indicator of insulin resistance and glucose intolerance.

Furthermore, BCAO markedly decreased hepatic triglyceride levels by increasing gene expressions of CPT-1 and PPAR-α, which are involved in fatty acid oxidation, and decreasing mRNA expressions of FAS and SREBP-1c, which are associated with fatty acid synthesis. 

More importantly, Cyanidin and malvidin markedly decreased fat accumulation in 3T3-L1 adipocytes by increasing CPT-1 and decreasing FAS expression in the liver fat metabolism and SREBP-1c expression in the regulation of the genes with the function of lipid metabolism in comparison with cyanidin-3-rutinoside, an anthocyanin, and malvidin-3,5-diglycosides, another anthocyanidin.

Where 3T3-L1 is a cell line derived from 3T3 cells used in biological research on adipose tissue.

These results suggested that unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) processed anti-obesity mechanism by preventing the exacerbation of lipid and glucose metabolism, the major's causes of weight gain.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrot's anti-weight gain possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid, and glucose metabolism in estrogen-deficient rats by AMPK activation by Park S1, Kang S, Jeong DY, Jeong SY, Park JJ, Yun HS. (PubMed)

Strawberry, the Delicious Fruit Which Processes Anti Colon Cancer Potential, Scientists Found

By Kyle J. Norton, Master of Nutrition

Strawberry, a delicious fruit may have a profound effect in the prevention and treatment of colon cancer, some studies suggested.

Colon cancer is a chronic and medical condition characterized by abnormal cell growth which starts in the lining of colonic tissue. At the advanced stage, the cancerous cells can travel a distance away to infect other healthy tissue and organ through blood and fluids circulation.

According to to the statistic provided by the American Cancer Society, colon cancer is the third most common cancer diagnosed in both men and women in the United States. In 2018, approximately, over 97,000 new cases the cancer are diagnosed, causing about 50,630 deaths.

Early diagnosed with colon cancer have an over  90%  of 5 years survival rate.

The exact causes of colon cancer are unknown. However, researchers suggested that chronic inflammation of the intestines such as ulcerative colitis and Crohn's disease and genetic mutation inherited from the parents are some prevalent major risk factors.

Furthermore, age, gender, people with polyps on the inner wall of the colon or rectum, personal and family history, poor diet, and unhealthy lifestyle are also associated to the increased risk of the onset of the disease.

Dr. Junga Lee, the lead scientist in the study "Diet and Lifestyle in Colorectal Cancer Survivors" wrote, "Lifestyle factors that include obesity, physical activity, and diet are emerging as potential critical elements in improving colorectal cancer survival outcomes". and "The association between colorectal cancer mortality and modifiable lifestyle factors is growing in evidence" and 

"Changes in individual health behaviors both before and after a diagnosis of colorectal cancer may improve outcomes of survivors. Several studies have indicated that maintaining a normal weight, participating in regular physical activity, and eating a healthy diet may be important preventative steps leading to improve survival outcomes".

These results suggested that a healthy diet accompanied by an active lifestyle not only can prevent the risk of colon cancer but also can increase the survival of people who already are infected by the disease. 

In the early onset of cancer, patients may not experience any symptoms. However, if you have symptoms of the change in your bowel habits that lasts longer than a month, accompanied by rectal bleeding or blood in your stool and persistent abdominal discomfort, please check with your doctor to rule out the possibility of colon cancer.

Strawberry is a genius of Fragaria × ananassa, belonging to the family Roseaceae. The fruits have been grown all over the world with a suitable climate for commercial profits and for health benefits.

Chemicals constituents
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

In the evaluate the recent discovery that ellagitannins (ETs), a class of hydrolyzable tannins found in some fruits and nuts, including strawberry may have beneficial effects against colon cancer, researchers at the University of Rhode Island launched an investigation to study whether, the efficacy of the ETs was a result from its function on ETs hydrolyzing the release ellagic acid (EA) and was converted by gut microbiota to urolithin A (UA; 3,8-dihydroxy-6H-dibenzopyran-6-one) type metabolites, which may persist in the colon through enterohepatic circulation.

On a human 293T cell line, using a luciferase reporter of canonical Wnt pathway-mediated transcriptional activation, researchers found that ETs isolated from strawberry= 20.5% GAE exerts a significant effect in inhibiting Wnt signaling in alternating healthy cells DNA transcript, the early sign of the onset of colon cancer.

These results suggested that strawberry with abundant bioactive compound ellagitannins (ETs) has a potential against colon carcinogenesis through gut microbiota.

On human colon cancer (CaCo-2) cells, according to the Scottish Crop Research Institute, strawberry extracts of EC 50 values in the range of 25-40 microg/(mL of phenols) demonstrated a strong activity against cancer cells proliferation.

Further analysis also found that The anthocyanin-rich fraction in the strawberry extract is considerably less effective than the original extract, whereas the antiproliferative activity is retained in the tannin-rich fraction. such ad ETs.

Additionally, in the examine the hypothesis of consumption of berry fruits, including strawberries ( Fragaria x ananassa Duch.), may have beneficial effects against oxidative stress-mediated diseases such as cancer, researchers found that all 10 phenolics compound isolated from strawberry ( cyanidin-3-glucoside ( 1), pelargonidin (2), pelargonidin-3-glucoside (3), pelargonidin-3-rutinoside (4), kaempferol (5), quercetin (6), kaempferol-3-(6'-coumaroyl)glucoside) (7), 3,4,5-trihydroxyphenyl-acrylic acid (8), glucose ester of ( E)- p-coumaric acid (9), and ellagic acid) display a significantly inhibitory activity against human colon cancer cell antiproliferation, by the Trolox equivalent antioxidant capacity (TEAC) and luminescent ATP cell viability assays, respectively, through the compounds antioxidant and antiproliferative activities.

Dr. Zhang Y, the lead researchers after taking into account co and confounders said, "This study adds to the growing body of data supporting the bioactivities of berry fruit phenolics and their potential impact on human health".

The findings suggested that people in the higher risk of colon cancer may want to add 1 or 2 portions of strawberry into their daily diet for preventive measure.

Taken all together, strawberry processed high levels of phenolics compound and ellagitannins (ETs) may be considered a functional food in reducing the risk and treatment of colon cancer.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of fruit ellagitannin extracts, ellagic acid, and their colonicmetabolite, urolithin A, on Wnt signaling by Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP. (PubMed)
(2) Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro by McDougall GJ, Ross HA, Ikeji M, Stewart D.(PubMed)
(3) Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(4) Diet and Lifestyle in Colorectal Cancer Survivors by Junga Lee,1 Justin Jeon,1 and Jeffrey A. Meyerhardt. (PMC)

Carrots, the Veggies with Anti Cancer Potential, Researchers Find

By Kyle J. Norton, Master of Nutrition

Carrot, the root veggie may have a potential and positive effect in blocking the proliferation of cancer cells, some scientists suggested.

Cancer is a class of chronic and medical diseases characterized by irregular and disordered cell growth in one or some tissue and organs in the body.

Most cancers start from the inner lining of the tissue of the organs then slowly spread to the deeper parts of the infected organs. At the advanced stage, most malignant cancer cells can travel a distance away from the original site to infect other healthy tissue and organs.

Most cancer diagnosed in the early have a 100%  5 years survival rate.

According to the statistic provided by the Canadian public health service, during their lifetime, nearly 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease.

Lung, colorectal, breast and prostate cancers account for half of all cancers diagnosed in Canada and over 25% of all cancer deaths in Canada are due to lung cancer.

The causes of cancers are unknown, however, scientists in the world agreed that there are several risk factors such as gene mutations inherited from the parents and acquired gene mutations caused by smoking, radiation, viruses, chemicals carcinogens, obesity, hormones, chronic inflammation, and physical inactivity are associated to the early onset of cancer.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

In the investigation of the claim of Lebanese folk medicine that Daucus carota, also known as wild carrot has a potency for treatment of various types of cancer, researchers at the Lebanese American University, conducted an experience to identify the major compound responsible for the anti-cancer activity of DCOE.

β-2-himachalen-6-ol, a novel sesquiterpene unique to β-2-Himachalen-6-ol isolated from the Lebanese wild carrot demonstrated potent anti-cancer activity against B16F-10, Caco-2, MB-MDA-231, A549, and SF-268 cancer cells (IC50 13-4µg/ml; 58-18µM), and SF-268 cells.

Furthermore, the sesquiterpene was shown to induce cell death through apoptosis (flow cytometry), decrease 2D cell motility (wound healing assay) and 3D invasion, as well as increase cell adhesion in SF-268 cells.

Additionally, β-2-himachalen-6-ol showed very low toxicity.

These results suggested that wild carrot β-2-himachalen-6-ol may have a potential multi-mechanistic chemotherapeutic drug with high potency and safety.

Moreover, in the concerns of the mortality rate caused by gastric cancer, researchers at the Shahid Sadoughi University of Medical Sciences conducted a review by searching the multiple databases including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx to determine the relationship between carrot consumption and gastric cancer.

Out of 81 articles found in the databases, only 5 studies satisfied the medical guidelines and criteria were included in the review. after taking into account co and confounders, researchers found that

* Intake of carrot regularly reduced the risk of gastric cancer by 26%.

* There is an inverse relationship between the consumption of carrots and the risk of gastric cancer.

More interestingly, regarding the inconsistent results. associated with carrot intake and prostate cancer risk, researchers at the Zhejiang University also launched a review by searching the databases of PubMed, EMBASE, Scopus, Web of Science, the Cochrane register, and the Chinese National Knowledge Infrastructure to determine whether intake of carrot may reduce the risk of prostate cancer.

At the final report, researchers found that
* Intake of carrot is associated with a significantly decreased risk of prostate cancer with the odds ratio of 0.82 which is consistency with the Shahid Sadoughi University of Medical Sciences study.

* Forr each serving per week or 10 g per day increment of carrot intake, the odds ratio of the risk of prostate cancer was 0.95, according to the dose-response meta-analysis.

The findings indicated that intake of carrot may have a potential effect in reducing the risk of the onset of cancers. 

However, due to the limited number of cohort studies and substantial heterogeneity observed between studies in this meta-analysis, further well-designed prospective studies are warranted to confirm the findings from the studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1)β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot by Taleb RI1, Najm P2, Shebaby W2, Boulos JC2, Demirdjian S2, Hariri E2, El-Sibai M2, Daher C2, Mroueh M3(PubMed)
(2) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3.(PubMed)
(3) Dietary carrot consumption and the risk of prostate cancer. by Xu X1, Cheng Y, Li S, Zhu Y, Xu X, Zheng X, Mao Q, Xie L.(PubMed)

Green Tea and Its Bioactive Polyphenols Inhibit Alpha1-Antitrypsin (AAT) Deficiency Against the Onset of Fibromyalgia

By Kyle J. Norton, Master of Nutrition


Green tea may have a therapeutic and positive effect in reducing onset. progression and treatment of Alpha1-Antitrypsin (AAT) deficiency in the induced fibromyalgia, some scientists suggested.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people the in the US alone.

Serum of alpha1-Antitrypsin (AAT) impregnated in most parts of body circulates in our body in high concentrations with function in the inhibition of the enzymes of inflammatory cells.

Alpha1-Antitrypsin (AAT) deficiency is a genetic disorder inherited from the parent characterized by of the inability of the body to produce a protein called alpha-1 anti-trypsin (AAT), leading to inflammation of fatty tissue under the skin (subcutaneous), and at other parts of the body, including the joints, the major cause of fibromyalgia.

Additionally, deficiency of AAT enynes also can cause the liver and lung damage, leading to poor function of the organ and increasing the risk of cirrhosis, COPD, liver and lung cancer. 

Although the deficiency is presented since birth, most patients with mutated gene do not experience any symptoms until the age of 50 or 60.

According to the statistic, AAT deficiency is one of the most common inherited disorders among Caucasian compared to other race groups. 

Approximately over 1% of patients diagnosed with chronic obstructive pulmonary disease (COPD)  processes the  alpha1-antitrypsin deficiency gene

In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.

Functional magnetic resonance imaging of these patients revealed a significantly greater activity in pain-sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.

Furthermore, patients with FM also were found to consist of abnormal profiles of inflammation markers in biopsies analysis.

The results suggested that these patients may have an imbalance level of pro-inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.

Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".

Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti-inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated proinflammatory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.

Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles but also stimulated the production of the body natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.

The evidence indicated that green tea EGCG may have a profound effect in reducing serum alpha1-Antitrypsin (AAT) deficiency in initiated the onset of fibromyalgia

The above differentiations were supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.

According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuating nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.

Dr. Helieh S. in the summary said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".

Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia. However, intake of green tea supplement should be taken with extreme care due to recent medical reports of acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC. (PubMed)
(3) Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)

Green Tea, The Beverage In the Alleviated Symptoms, Reduces Risk and Treatment of Polymyalgia Rheumatica (PMR)

By Kyle J. Norton, Master of Nutrition


Green tea may have a therapeutic and positive effect in reducing the symptoms, risk, progression, and treatment of polymyalgia rheumatica (PMR), some scientists suggested.


Polymyalgia rheumatica an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.

The exact causes of polymyalgia rheumatica are unknown. However, researchers do know that certain prevalent risk factors are associated with the onset of diseases, such as age, family history, gender, ethnicity and exposure to environmental weather.

Genetic mutations inherited from the parents are also the major risk factor for the development of polymyalgia arthritis such as ICAM-1 (intercellular adhesion molecule 1), RANTES (regulated upon activation, normal T cell expressed, and presumably secreted). 

It is important to know that Giant cell arteritis (GCA) (temporal arteritis) and polymyalgia rheumatica (PMR) share the common identity, frequently related conditions in people generally over 50 years of age, according to the Dr. Miguel A Gonzalez-Gay in the study of " Genetic epidemiology: Giant cell arteritis and polymyalgia rheumatica".

Symptoms of PMR are depending on the severity of the condition, including aches or pain shoulders,  neck, upper arms, buttocks, hips or thighs, and stiffness in affected areas.

People with PMR also experience pain in the morning or after being inactive for a time,  limited range of motion in the affected areas.

If you have some of the above symptoms, please check with your doctor to rule out the PMR possibility.

Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.


In an animal study of inflammatory diseases induced by injection of LPS, researchers found that application of green tea bioactive polyphenols EGCG improves antioxidant status of the host and decreases the production of inflammatory factors, including PMR through its antioxidant properties.

Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of immune system in the protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.

The bioactive compound also inhibited reactive oxygen species (ROS) in stimulating the production of inflammatory cytokines through stopping the free radicals chain reactions that facilitate inflammation and the precipitate skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue.

In fact, overproduction of ROS increased expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases can cause an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.

The further evaluation suggested that green tea EGCG also reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.

Long-term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complications of several chronic inflammatory diseases through the generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,

Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in the regulation of innate and adaptive immune functions and served as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor alpha (TNF-α) in promoting muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.

Importantly, application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.

These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.

Deficiency of glutathione levels was found to associate to the early onset of polymyalgia rheumatica, inducing symptoms of pain, stiffness, achiness, fatigue, and fever.

Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with the function to target pro-inflammation cytokines in the relieved stiffness and pain in patients with polymyalgia arthritis.

Taken all together, green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression and treatment of polymyalgia rheumatica(PMR).

However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3. (PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM. (PubMed)