* Carrot and Its Bioactive Chemical Compounds in Reduced Risk and Treatment of Colon Cancer

Kyle J. Norton, Master of Nutrition

Carrots may have a profound and positive effect in reduced risk, progression and treatment of colon cancer, some scientists suggested.

Colon cancer is a chronic condition characterized by irregular cell growth in the colon tissue. At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue and organs.

As of today, researchers do not know what cause colon cancer. However, certain risk factors, such as genetic mutations that induce healthy DNA change are associated to increase risk of cancer.

Some researchers suggested that unhealthy diet  and life style such as American diet  with high intake of red meat, low intake of fiber, low intake of calcium, cigarette smoking,.... and obesity are the prevalent risk factors of colon cancer(4).

And increase consumption of a wide variety of fruit and vegetable, particularly, dark-green leafy, cruciferous, a deep-yellow on tones, and fibre are convincing preventive factors(5).

Dr. Corrêa Lima MP, the lead author at the Mato Grosso Federal University said, " lifestyle modification including proper diet such as the ones rich in vegetable and poor in red meat and fat, regular physical activity and maintaining an appropriate body weight and avoiding the use of tobacco and alcohol may lead to reduce colorectal cancer risk"(5).

Patients in early stage colon cancer may experience gastrointestinal symptoms of changes in your bowel habits, constipation. diarrhea or alternating diarrhea and constipation. Some patients may also develop symptoms of  from rectal bleeding or blood in your stool, abdominal bloating,.... and cramps or discomfort.

Truly, some chronic conditions and medicine use for treatments also were found to increased risk of colon cancer, including diabetes, acromegaly, a growth hormone disorder, ,,, and radiation treatment for other cancers.

In US, colorectal cancer is the third most common cancer diagnosed in both men and women. 

According to statistic of American Cancer Society, in 2018, approximately, 97,220 new cases of colon cancer.and 43,030 new cases of rectal cancer.are diagnosed in US. Colorectal cancer also causes death of 50,630 during 2018(6).

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

According to the study to determine the anticancer activity of the pentane fraction (F1) and the 1:1 pentane:diethyl ether fraction (F2) isolated from Daucus Carota oil extract (DCOE) against human colon adenocarcinoma cell lines (HT-29 and Caco-2), application of various concentration of both extracts exerted significant inhibitory effect against proliferation and induced apoptosis through numbers of factors.

The observation by Western blot revealed that the activity of F1 and F2 constrict the tumors expansion through activation of caspase-3, the key protein facilitators with function to execute apoptosis or program cell death and PARP cleavage, with function in stimulated various pathological cell death processes.  

Further analysis also suggested that F1 and F2 inhibited the cell death processes through increased levels of Bax expression in initiated pro-apoptotsis involved in a wide variety of cellular activities and p53 in regulated cell cycle as a tumor suppressor.

Together, both injections also deceased levels of Bcl-2 with function in inhibited tumor cells apoptosis.

Moreover, treatment of HT-29 cells with either fraction markedly also induced cell adhesion, cell cycle progression, cell migration, cell apoptosis through decreased the levels of both phosphorylated Erk and Akt.

Activation of oncogenic signalling proteins AKT and ERK by phosphorylation has an established role in the development of certain types of cancer(7).

Additionally, in mice model, β-2-himachalen-6-ol (HC) isolated from the Daucus carota oil extract st the concentration of 1, 5, 10 and 25 μg/ml, were also found to inhibit numbers of cancers, including colon cell progression.

In SW1116 colon cancer cell lines, injection of β-2-himachalen-6-ol (HC) demonstrated a significantly inhibitory activity in a dose-dependent in decreased cell survival with an IC50 of 18 and 14.5 μg/ml after 24 and 48 h respectively.

According to the Flow cytometry analysis, at concentration of 10 μg/ml, HC increased the number of tumors cells undergoing necrosis of 18.05% and 58.01% and late apoptosis of 15.66% and 30.47%, respectively.

These results suggested that β-2-himachalen-6-ol (HC) induced cancer cell apoptosis and cancer growth restriction, linearly in doses dependent manner.

Additional differentiation also suggested the application exerted anti colon cancers cell line effect through similar proteins and pathways as mentioned in the first study.

Most importantly, β-2-himachalen-6-ol (HC) in inhibited colon cancer cell line through cytotoxicity in cell cycle arrested without causing harm to the nearby health cells.

The above illustration were also supported by the investigation of beta-carotene and lycopene, a bioactive phytochemical found in carrot in a modify luminal process relevant to colon carcinogenesis conducted by the Technical University of Munich.

According to the randomized cross-over trial of twenty-two healthy young men on a low-carotenoid diet consumed 330 ml tomato or carrot juice per d for 2 weeks, consumption of carrot juice led to a marked increase of beta-carotene and alpha-carotene in faecal water with high dose-dependent cytotoxic and anti-proliferative effects on colon adenocarcinoma cells (HT29).

Taken together, carrot and its bioactive compounds may be considered as function food in ameliorated risk and increased efficacy of conventional medicine for treatment of colon cancer.

However, further data collection on large example size and multi centers studies performed with human consumption of the carrot and its bioactive phytochemicals, during the course of the disease will be necessary to complete the picture of their anti colon cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shebaby WN1, Bodman-Smith KB1, Mansour A2, Mroueh M3, Taleb RI4, El-Sibai M4, Daher CF4.(PubMed)
(2) Effects of carrot and tomato juice consumption on faecal markers relevant to coloncarcinogenesis in humans by Schnäbele K1, Briviba K, Bub A, Roser S, Pool-Zobel BL, Rechkemmer G.(PubMed)

(3) Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways by Daaboul HE1, Daher CF2, Bodman-Smith K1, Taleb RI2, Shebaby WN2, Boulos J2, Dagher C3, Mroueh MA4, El-Sibai M5.(PubMed)
(4) Lifestyle Factors and Their Combined Impact on the Risk of Colorectal Polyps by Zhenming Fu, Martha J. Shrubsole, Walter E. Smalley, Huiyun Wu, Zhi Chen, Yu Shyr, Reid M. Ness, and Wei Zheng(PMC)
(5) Colorectal cancer: lifestyle and dietary factors by Corrêa Lima MP1, Gomes-da-Silva MH(PubMed)
(6) Key Statistics for Colorectal Cancer by American Cancer Society
(7) ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing by Crosbie PA1, Crosbie EJ2, Aspinall-O'Dea M3, Walker M3, Harrison R4, Pernemalm M5, Shah R6, Joseph L7, Booton R8, Pierce A3, Whetton AD(PubMed)

* Surprise You? Learn How Traditional Chinese Medicine (TCM) Differentiate and Treat Bladder Cancer

Kyle J. Norton

Bladder cancer occurs when cells mass in the inner lining of the bladder form a malignant growth, or tumor. In other words, bladder cancer is a medical condition caused by irregular growth of cells in bladder tissue.

The seriousness of the condition is depending on the penetration of cancerous cells.. At the early stage, the cancerous only are found on the surface of the bladder.

However, at the later stage, the uncontrollable cells may travel a distance away  from the bladder to infect other healthy cells and tissue of other organs through bloods and fluids circulation, such as the prostate gland in men or uterus in women.

Symptoms(1)
1. Traditional Chinese medicine indicated that urinary with blood is one of the first symptom discovered by bladder cancer patient. Sometimes, red blood cells can be viewed by naked eyes but most of the times, it requires a blood test.
2. Back pain
3. Fluid retention in the kidney
4. Fever
5. Other symptoms are similar to the conventional medicine.
Most patient with early bladder cancer my experience blood in urine with no pain at all.

Risk Factors(1)
1. Occupation
Occupation required to contact with chemical toxins daily and over a prolonged period of time have a high risk of bladder cancer. Most workers do not experience any symptom of bladder cancer until later in their life. We are taking about the period over 30 years.

2. Smoking
Cigarette contains certain harmful chemicals which can cause cancer. In China, due to social culture difference, the risk of male and female with bladder cancer is 41%, 30% accordingly.

3. Age
The risk of bladder cancer increases with age. The older you are, the higher the risk.

4. Sex
The risk of bladder cancer of male is 4 time higher than women

5. Race
Certain race are high risk of bladder cancer

6. Chemicals tryptophan
By products of tryptophan such as 3-hydroxy-2-amino-acetophenone and 3-Hydroxyindazole
can promote the risk of bladder cancer due to reaction of β-glucuronidases.

7. Diet
Diet high in saturated fat increases the risk of bladder cancer.

8. Family history
Bladder cancer risk increase if a member of the direct family have bladder cancer.

9. Infection
Prolonged infection or frequent infection increase the risk of bladder cancer.

10. Medication
Certain types of medication can promote the forming of bladder cancer.


Causes of Bladder cancer in TCM
The traditional Chinese medicine defined bladder cancer is a health condition caused by
A. Heart Fire Shifting Downwards to the small intestine
Heart Fire is an excess problem, due to elevating yang or yang rise is out of control. Since heart is associated with the fire, excessive yang leading to fire and heat.

If heart fire with extra heat move downward to the small intestine, it affects the bladder in functioning of urinary secretion, causing blood in urine.

In other words, according to the article by TCM Shen Nong Shi,  bloody urine often indicates that the bladder meridian is over-heated, that can be a result of different internal disharmonies. Mental stress, improper diet or chronic health conditions bring about fire or heat pathogensby different organs, the pathogens irritate the urinary tract through the bladder meridian, and cause bleeding(2).

If left untreated, it can cause inflammation and bleeding, leading to bladder cancer.

1. Symptoms include(4)
1.a. Heart palpitations
1.b. Thirst
1.c. Feeling of heat
1.d. Urination with blood
1.e. Hot, dark urine
1.f. Bitter taste in the mouth
1.g. Frequent urination
1.h. Urgent need to urinate


2. Treatment with Chinese Herbs
2.1. Shui Niu Jiao (Bubalus bubalis)(3)
Shui Niu Jiao is also known as water buffalo horn. The salty, cold herb has been used in TCM as sedative, anti-inflammatory, anti-virus medicine and to shorten bleeding time, enhance quality of capillaries as it clears heat, relieve fire, cool blood, stop nosebleed, vomiting blood by enhancing the function of heart, liver, spleen, stomach channels.

2.2.  Lian Qiao (Fructus Forsythiae Suspensae)(5)
Lian Qiao is also known as forsythia fruit. The bitter, cool, and slightly acrid herb has been used in TCM as anti inflammatory medicine and to stop vomiting, promote blood circulation and urination as it helps to clears heat and toxin and expels externally wind heat by enhancing the function of heart, liver gall bladder channels.

2.3. Dan Zhu Ye (Herba Loaphatheri Gracilis)(7)
Dan Zhu ye is also known as bamboo leaves. The sweet, cold and bitter herb has been used in TCM to treat mouth sores and inflamed gums caused by heat, promotes urination and treat insomnia as it helps to clear damp heat, heart fire and stomach heat by enhancing the functions of heart, small intestine, stomach channels.

2.4. Lian Zi Xin (Lotus Plumule)(6)
Lian Zi Xin also known as Lotus Flower. The bitter and cold herb has been used in TCM as an astringent and to treat insomnia, irritability, stop bleeding and vomiting blood as it promotes the draining of heart fire and bind essence by enhancing the functions of heart and pericardium channels.



B. Damp heat moves downward to the bladder
It is caused by kidney inability to move fluid upward, resulting in fluid accumulated in the abdomen. Prolonged period of fluid accumulation promotes arise of heat, affecting the urinary secretion of the bladder, resulting of bleeding and damage the functioning of the bladder, leading to bladder cancer(8).

1. Symptoms include(8)
1.a. Frequent urination
1.b. Urgent need to urinate
1.c. Urinary pain, back pain, edema of lower limbs
1.d. Thirsty,
1.e. Difficult to go to sleep at night
1.f. Red tongue with yellow and greasy fur
1.g. Slippery and taut pulse

2. Treatment with Chinese Herbs
The function of the herbs are for diuresis, to eliminate dampness, clear heat, cool blood and stop bleeding.
2.1. Che Qian Zi (Semen Plantaginis)(9)
Che Qian Zi is also known as Plantain seed. The sweet and cold herb has been used in TCM as an antibiotic and to promote urination and to excret mucus of the bronchial tubes as it helps to clear Damp heat in the lower burner channel and damp heat cause of painful urinary, diarrhea , red eyes and sexual dysfunction by enhancing the functions of bladder, kidney, liver, lung channels.

2.2. Bian Xu (Herba Polygoni Avicularis)(10)
Bian Xu is also known as common knotgrass. The slight cold and bitter herb has been used in TCM to treat urinary infection, get rid of skin parasites and fuild and worms and stop itching as it drains damp heat in bladder, calms pain on urination by enhancing the function of bladder channel.

2.3.  Bo Ye (Cacumen Biotae Orientalis)(11)
Bo Ye or Ce Bai Ye is also known as biota leaves. The bitter, tart and slightly cold herb has been used in TCM to stops bleeding, harmonize blood, inhibit cough, anti-bacteria and anti-inflammation as it purifies and lowers the lung-Qi , clears heat and blood heat, eliminates phlegm by enhancing the function of heart, liver, large intestine and lung channels.

2.4. Yi Yi Ren (Semen coicis)(12)
Yi Yi Ren is also known as Coix Seed. The sweet, bland, slightly cool herb has been used in TCM to improve digestion, enhance the lung function, get rid of bacterial or fungal infection and treat neualgia, difficulty in urination, lung abscess as it drains water, strengthens the Spleen; eliminates obstruction and clears Heat by promoting the functions of spleen, stomach, lung channels.

2.5 Pu Gong Ying ( Herba Taraxaci Mongolici cum Radice)(13)
Pu Gong Ying also best known as Dandelion. The bitter, cold and sweet herb has been used in TCM as a diuretic and to promote bile secretion, protect the liver, inhibit staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa as it clears heat, expels toxins, drains Dampness by enhencing the function of liver and stomach channels.


C. Kidney and liver yin deficiency(14)
Kidney and liver yin deficiency cause of yang elevation, toxin accumulation and blood stagnation in the bladder that can lead to the forming of tumor.
This type is mostly seen at the advanced age, or chemotherapy or radiotherapy cause of heat reaction or complicated by infection.
1. Symptoms include(14)
1.a. Frequent urination, sometimes
1.b. Blood in the urine
1. c. Abdominal distension and pain
1.d. Back pain
1.e. Dry mouth but don't like to drink
1.f. Constipation
1.g. Light red tongue with little fur, or uncoated and smooth tongue
1. h. Thready pulse


2. Treatment with Chinese Herbs
The main functions of herb are to nourish yin, invigorate kidney, clear stagnation and detoxify.
2.1.  Mai Dong (Tuber Ophiopogonis Japonici)(15)
Mai Dong is also known as Ophiopogon Root. The sweet, slight bitter and cold herb has been used in TCM to improve contraction of heart muscles, recovery of cells of the pancreas and immune system, protect heart muscle, lower blood sugar and anti-arrhythmia as it
moistens the lungs, nourishes Lung-Yin, benefits the stomach and the heart, promotes generation of body fluids, clear heat by promoting the functions of heart, lung, stomach channels.

2.2.  Shi Hu (Herba Dendrobii)(16)
Shi Hu is also known as Dendrobium. The sweet, bland, slightly cold herb has been used in TCM to treat weakness after febrile diseases, thirsty, thromboangitis obliterans, chronic throat infection, blurry vision and weak lower back as it nourishes the stomach and yin, clear heat, promotes generation of body fluids by enhancing the lung and stomach channels.

2.3. Nu Zhen Zi (Fructus Ligustri Lucidi)(17)
Nu Zhen Zi is also known as Glossy Privet Fruit. The bitter, sweet and neutral herb has been used to promote immune system and circulatory system, anti inflammatory, anti cancer properties, lower blood sugar and protect the liver as it tonifies the liver and kidneys, clears heat and improves vision by soothing the functions of liver and kidney channels.

2.4. Long Kui (Herb Solani nigri)(18)
Long Kui is also known as wonderberry. The bitter, cold, slightly sweet and toxic herb has been used in TCM as diuretic and antipyretic and to treat acute kidney inflammation, chronic bronchitis, throat cancer, larynx Cancer, uterus cancer as it clears heat, eliminates toxin, improve urination by enhancing the function of liver, kidney and stomach channels.

2.5. Fu Ling (Sclerotium Poriae Cocos)(19)
Fu Ling is also known as Indian Bread. The sweet, bland, neutral herb has been used in TCM as a diuretics and to treat insomnia or forgetfulness, loss of appetite and inflammation of the uterus and chronic sinusitis as it eliminates water, strengthens the spleen, calms the mind, clear damp-heat by enhancing the function of heart, spleen, lung, kidney channels.


Treated Bladder Cancer with Foods in TCM
In traditional Chinese medicine, the herb, Ling Zhi (Reishi mushroom) is viewed to process substances with antibacteria, antivirus and antitumor properties.

 In general public, most mushrooms contain the same values but differing in volume.
1. Shiitake or Chinese black mushroom(20)
Shiitake contains protein, glutamic acid, low cholesterol, β-glucosidase and 18 amino acids. Some researchers found that shiitake mushroom may stimulate the immune system, possess antibacterial properties, reduce platelet aggregation, and possess antiviral properties, possibly through antiviral agents known as proteinase inhibitors.

Lentinan in Shiitake enhances the immune function and prevents our body against cancer. The substance of interferon inducer may be used to treat cancer(21).

2. Agaricus campestris
Agaricus campestris contains high amount of B vitamin and inorganic salts. In rat study, researchers found that Agaricus campestris inhibits the progression of cancer cells(22).

3. Hericium erinaceus

One of the favorite food in many Chinese expensive recipe, Hericium erinaceus may inhibit the growth of tumor. In China, Some of the pharmaceutical drug company have made them in form of Mushroom slices for use in preventing and treating stomach and Esophageal cancer(23).

4. Tremella(24)
Tremella contains high amount of fiber, protein, calcium, polysaccharides, etc. Researchers found that tremella enhances the immune system scavenging, T cells and B lymphocytes functions, thus preventing the progression of cancer cells.

5. Flammulina(25)
Beside it has been used in TCM to treat liver inflammation, ulcer and lower blood cholesterol, in 1982 study, researchers in Japan found that certain substances in flammulina help to protect our body against cells DNA mutation cause of cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Kyle J. Norton, Bladder Cancer
(2) Blood in Urine and Chinese Medicine by Shen-Nong-Shi
(3)Shui Niu Jiao (Bubalus bubalis) by American Dragon

(4) Heart Fire, The kind of Heat in your Heart you don't want! by Acupuncture Points
(5) Chinese Herbs – Lian Qiao (Fructus Forsythiae Suspensae) 
(6) Chinese Herbs -Lian Xin or Lian Zi Xin (Plumula Nelumbinis Nuciferae)
(7) Dan Zhu Ye (Lophatherum Stem and Leaves)
(8) Damp Heat Moving Down Ward to Bladder
(9) Che Qian Zi (Plantago Seed, Plantain Seed)
(10) Bian Xu (Herba Polygoni Avicularis)
(11) Chinese Herbs – Bo Ye (Cacumen Biotae Orientalis)
(12) Chinese Herbs - Yi Yi Ren (Semen Coicis Lachryma-Jobi)
(13) Pu Gong Ying (Dandelion)
(14) Liver and Kidney Yin Deficiency
(15) Chinese Herbs – Mai Dong or Mai Men Dong (Tuber Ophiopogonis Japonici)
(16) Chinese Herbs – Shi Hu (Herba Dendrobii)
(17) Chinese Herbs – Nu Zhen Zi (Fructus Ligustri Lucidi)
(18) Chinese Herbs– Long Kui (Herb Solani nigri)
(19) Chinese Herbs – Fu Ling (Sclerotium Poriae Cocos)
(20_ Recent developments in mushrooms as anti-cancer therapeutics: a review by Seema Patel1 and Arun Goyal(PMC)
(21) NCI Dictionary of Cancer Terms
(22) Medicinal Mushroom Extracts Possess Differential Antioxidant Activity and Cytotoxicity to Cancer Cells by Elbatrawy EN1, Ghonimy EA2, Alassar MM3, Wu FS(PubMed).
(23) Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers by Li G1, Yu K1, Li F1, Xu K1, Li J1, He S2, Cao S3, Tan G(PubMed)
(24) Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk by Han CK1, Chiang HC2, Lin CY3, Tang CH4, Lee H5,6,7,8, Huang DD3, Zeng YR3, Chuang TN3, Huang YL(PubMed)
(25) Treatment of cancer with mushroom products by Monro JA(PubMed).

*Green Tea and It's Bioactive Epigallocatechin 3-gallate (EGCG) That Target Arthritis With No Side Effects, Scientists Suggested

By Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of arthritis, some scientists suggested.

Arthritis is a class of chronic condition characterized by painful inflammation and stiffness of the joints, usually seen in adults over the age of 65.

Others symptoms of arthritis also include redness, warmth, swelling, and decreased motion of the affected joints.

Rheumatoid Arthritis in severe cases can also effect the bone density, cause skin nodules, eye,...... and lung inflammation and scarring.

As of today. there are no cure of the disease. Depending to types of arthritis, analgesics and Nonsteroidal anti-inflammatory drugs (NSAIDs) are common use for treatment of pain and inflammation. However, in rheumatoid arthritis medicine, disease-modifying antirheumatic drugs (DMARDs) and Corticosteroids are the first line medicine use to suppress over active immune system in attacking its own joints.

Most arthritis are caused by wear and tear of the joints. However, long term infection or injury without proper treatment can elevate the natural breakdown of cartilage tissue of the joints.

According to CDC(5), in the years of 2013–2015, approximately 22.7% or 54.4 million are affected by the disease, with significantly higher age-adjusted prevalence in women (23.5%) than in men (18.1%).

Although, arthritis prevalence increases with age, physical inactivity is associated to higher risk of arthritis development.

Sadly, the CDC continued, "With the aging of the US population, the prevalence of doctor-diagnosed arthritis is expected to increase in the coming decades. By the year 2040, an estimated 78.4 million".

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

According to the College of Pharmacy, green tea epigallocatechin 3-gallate (EGCG) in preclinical studies displayed a significant effect in treatment of arthritic disease.

In vitro, application of green tea extract EGCG demonstrated activities in cartilage-preserving and chondroprotective action through reduced expression of proinflammatory IL-1β, TNFα, and IL-6
and modulated extracellular matrix (ECM) turnover induced changes of the biomechanical environment of chondrocytes and accelerate the degradation of cartilage as well driving the progression of the disease in the presence of inflammation.

Normal extracellular matrix (ECM) is a composed collagen type II with function to provide tensile support for the tissue.

Further analysis in expression of proinflamatory factors researchers found that the over expression of proinflammatory cytokines IL-1 and IL-6 were associated correlatively in knee joints in arthritis and inhibition of IL-1 snd IL-6 by green tea EGCG IL-1 showed to reduce joint damage.

Some researchers also suggested that Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading to chronic inflammation.

In expression of tumor necrosis factor (TNF), tumor necrosis factor alpha(TNFα, cachexin, or cachectin), application of green tea inhibited the levels of TNFα in induction of synovial fibroblast cytotoxicity.

Interestingly, in the study to evaluate the possible effects of the administration of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, researchers indicated that green tea daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days displays a strong effect in decreased symptoms of arthritis by ameliorated diminutions in protein and lipid damage in liver, brain and plasma, through antioxidant effect in reduced levels of ROS in stimulated free radical chain reaction to initiate production of pro inflammatory cytokines in precipitated chronic diseases.

Rats treated with green tea EGCG also showed a significant improvement in restored natural antioxidant glutathione (GSH) and protein thiol levels produced by the body, by exhibiting the activities of the antioxidant enzymes.

Moreover, green tea injection also normalized the activity of glucose 6-phosphate dehydrogenase, which is increased in the liver of arthritic patients and considered as a risk factor for the development of arthritis. Increased activity glucose 6-phosphate dehydrogenase was associated to reactive oxygen species (ROS) generated in oxidative metabolism in inflicted damage on all classes of macromolecules.

Additional differentiation of green tea EGCG immunomodulatory effects and mechanisms on experimental arthritis induced by collagen-induced arthritis (CIA) mice in compared to control received phosphate buffered saline (PBS), researchers found that application of green tea EGCG at dose of 10 mg/kg demonstrated a strong effect in ameliorated clinical symptoms and reduced histological scores, through modulated the immune activity by induced over expression of the Nrf-2 antioxidant pathway, a major mechanism in the cellular defense against oxidative or electrophilic stress through detoxication and elimination.

EGCG also ameliorated experimental arthritis in mice by eliciting indoleamine-2,3-dioxygenase (IDO) through inhibition of pro-inflammatory cytokine interferon-gamma, astrocytes and microglia in facilitated production of dendritic cells (DCs) that activate the immune system to attack the dendritic cell located on surface on the joint tissue.

Application of the EGCG also increased frequencies of T regs with a dominant role in suppression of autoimmune pathology.

Some researchers suggested that increased Treg number and/or function in model systems may have a significant effect in both prevented and reversed arthritis disease.

Taken together, green tea with abundant bioactive polyphenol epigallocatechin 3-gallate (EGCG) may be considered as a functional food for alleviated symptoms, reduced risk, and progression and treatment of arthritis.

However, further data collection on large example size and multi centers studies performed with human consumption of the green tea and its bioactive polyphenol epigallocatechin 3-gallate (EGCG), during the course of the disease will be necessary to complete the picture of their anti arthritis possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S1,3, Kwon SR1,4, Vanarsa K1,3, Kim HY4, Davis LS#1, Mohan C(PubMed)
(3) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(4) Is IL-1 a good therapeutic target in the treatment of arthritis? by Burger D1, Dayer JM, Palmer G, Gabay C.(PubMed)
(5) National Statistics by CDC

*Topical Arnica Better than Ibuprofen in Alleviated Pain and Sped Up Muscle Healing, Scientists Say

By Kyle J. Norton

Arnica may have a profound and positive effect in reduced pain and numbness caused by inflammatory muscles, some scientists suggested.

The results were demonstrated in some research papers conducted by numbers of institutes, including the University of Exeter.

Muscle pain is a natural reaction of the human brain that protects our body against muscle damage and injures by the activated immune response in signaling systemic inflammation in the acute phase of infection.

However, overproduction of pro-inflammatory cytokines may cause damage to the nearby healthy cells and death of injuring cells in the area, leading to irreversible scars of the skin and tissue.

Most common causes of muscle pain are localized with tension, stress, overuse,...... and minor injuries. However Systemic muscle pain caused by infection and side effects of medication intake can induce pain throughout the entire body.

According to Safe Medicine, people who are taking medications that treat high blood cholesterol such as atorvastatin, pravastatin, simvastatin, pitavastatin, and rosuvastatin are likely to experience muscle pain.

Chronic muscle pain caused by complications of chronic diseases such as chronic exertional compartment syndrome, chronic fatigue syndrome, fibromyalgia,.... and claudication dermatomyositis are associated to increase psychological symptoms such as depression and physical symptoms of a sleep disorder such as insomnia and reduced quality of life.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.


The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the study to evaluate the arnica patch effect in a 55-year-old female patient with pain in the right hand and numbness in the fourth finger after cellulitis in the palmar area, after the failure of antibiotics to alleviated pain observed by reading the indication 0-to-10-point visual analog scale (VAS).

The pain symptoms remained at 7 points after injection of ibuprofen, the conventional pain medicine.

According to the result of the study topical administration after 3 days of Arnica patch stripped to cover all painful areas of the hand and applied them at night exerted a pain and numbness relief and reduced size of a tender nodule on the third metacarpal area.

The self-report pain scale reading of 1, also marked a significant reduction and efficacy of the topical herbal Arnica.

Furthermore, the tested patient was able to sleep through the night without being awakened by the pain.

Moreover, all symptoms declined even more during the next 2 days.

Dr. Barkey E, after taking into account co and confounders said, " after a relatively short period of time, the administration of the Arnica patch on the hand provided a marked reduction of pain and recovery of the functionality of the hand".

These results suggested that Arnica may have a therapeutic effect in inhibited particular pro inflammatory cytokines in the initiation of the persistence of pathologic pain by directly activating nociceptive sensory neurons without reducing the activities of immune activity in protected the body tissues against infectious microorganisms.

Some researchers suggested that these results may also be attributed to Arnica ability to inhibit overexpression of reactive oxygen species (ROS) induction of inflammation through its antioxidant bioactive phytochemicals and stimulation of the production of antioxidant defense in the host body and tissue.

Truly, by balancing the ratio of ROS and levels of antioxidants in the body, and inhibited production of pro-inflammatory factors, Arnica may have the potential effect to alleviate pain and numbness of infectious muscles, joints, and hands of the patients.

Interestingly, in a double-blind, randomized comparison of Arnica administration versus placebo of a total of 37 patients undergoing bilateral endoscopic carpal-tunnel release between June 1998 and January 2000 at the at the Queen Victoria NHS Trust. researchers found that there were no group differences on the primary outcome measures of grip strength or wrist circumference.

However, Arnica treatment group showed a significant reduction in pain experienced after 2 weeks in compared to control.

Although Arnica application displayed strong properties in reduced pain symptoms of the tested patients, due to the small size of the sample, Dr. Stevinson C, the lead scientist said, "The role of homeopathic and herbal agents for recovery after surgery merits further investigation".

Taken together, topical herbal Arnica may be considered as a potential secondary therapeutic treatment in alleviated pain and numbness, particularly, in the patient who experiences some intolerant adverse effect induced by intake of conventional medicine.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Homeopathic Arnica Patch for the Relief of Cellulitis-derived Pain and Numbness in the Hand by Barkey E1, Kaszkin-Bettag M.(PubMed)
(2) Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery by Stevinson C1, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E.(PubMed)
(3) Use of Arnica to relieve pain after carpal-tunnel release surgery by Jeffrey SL1, Belcher HJ.(PubMed)

Andrographis paniculata, The Herbal Medicine Stops Plaques Accumulated in Neurons and Production of Inmature Neurons That Cause Alzheimer's disease, Scientists Say

Kyle J. Norton, Master of Nutrition 

Herbal Andrographolide may process a neural protective effect in the prevention of early onset of Alzheimer's disease, a common type of dementia, a study suggested.

Alzheimer's disease (AD) is a chronic neurodegenerative disease that is irreversible and starts slowly and worsens over time, affecting patients thinking ability and memory, correlated with major reductions of neurons to the respective target areas. The disease is named after German physician Alois Alzheimer.

Some researchers suggested that the disease is caused by a prolonged period of plaques excessive accumulation in the brain cells,  leading to brain cells degeneration and death.

People with Alzheimer's disease may experience the decline of cognitive and functional abilities, change of motions and moods and behavior, particularly, in reducing quality of life due to disability in physical activity.

According to the statistic provided by the Alzheimer.Net, approximately, 44 million people have Alzheimer’s or related dementia worldwide. The disease is most common in North America and Western Europe.

 Alzheimer’s disease is the 6th leading cause of death in the United States.

In the US, Alzheimer’s cost the United States taxpayer $259 billion in 2017.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

According to the joint study lead by the Pontificia Universidad Catolica de Chile, oral administrated natural product (Andrographolide, ANDRO) isolated from Andrographis paniculata in species Octodon degus (degu) exhibited the recovery of spatial memory and learning performance, through regulated phosphorylated tau protein and amyloid beta aggregate maturation in cell survival in inducing Alzheimer's disease.

Dr., the lead author in the joint study said, "(Andrographolide, ANDRO) inhibited) neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD"

Additionally, Andrographolide also displayed the inhibitory activity of against forming of amyloid beta (Aβ)42 through suppression of NF-κB, a protein that regulates cell survival and function of microglia in activated response to brain damage and immunological stimuli together with the reduction in the production of pro inflammatory cytokines.

In animal study, mice treated with Andrographolide increased neural progenitor cell proliferation and decreased the number of immature neurons in the hippocampus, compared to age-matched control mice.

Moreover, ANDRO increased the number of newborn dentate granule neurons in various parts of the brain.

The study also found that the efficacy that reduces symptoms and protects against the early onset of the AD is the results of the stimulation of neurogenesis in the hippocampus.

Taking together, Andrographis paniculata is surely consisted as a therapeutic potential to protect the development of Alzheimer's disease through various mechanisms, however, intake of large amount daily should be taken with care.

However, additional data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Andrographis paniculata anti-Alzheimer's disease possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.(PubMed)

*Aloe Vera, The Herbal Remedy That Delays Onset of Skin Aging Naturally, BioMedical Literature Reveal

Kyle J. Norton, Master of Nutrition


Aloe Vera or Aloe Vera supplement may be used to delay skin aging that causes expression of wrinkle, some scientists suggested.

Skin aging is a natural and biological process that change with age including wrinkles, age spots and dryness.

As we age, the skin also becomes thinner and loses fat, these conditions increase less plump and smooth. In case of injure, the skin also.takes longer to heal, too.

Wrinkle is a skin degenerative condition caused by the loss of dermis and subcutaneous fat layer underneath the skin, leading to a slight line or fold on the skin, particular in the face.

Unhealthy diet and life style also are major factors that increase early onset of skin aging.

Stacey Colino, a freelance Health & Wellness reporter at U.S. News, in the article of  "6 Surprising Factors That Can Accelerate the Aging of Your Skin" suggested that consuming lots of highly processed or sugary foods, always sleeping on the same side, being depressed, yo yo diet, long term intake of certain medicine such as corticosteroids, antibiotics, ACE inhibitors and diuretics and being a frequent flyer are also associated to prevalent risk factors of early aging(6).

Smoking causes over expression of free radicals that can damage skin cells in facilitated premature wrinkles.

Other causable factors such as stress, gravity, daily facial movement, obesity,..... and even sleep pattern may also have some effects in stimulated premature aging.

According to the University of Paris VI, free radical generation in the skin by UV light and from other sources, such as cellular infiltrations or the xanthine oxidase reaction also may contribute to at least retardation of premature cutaneous aging(4).

In the report of “Global Anti-Aging Market Research Report and Forecast to 2017-2022” published by OrbisResearch.com, the writer wrote, "The Global Anti-Aging Market was worth $250 billion in 2016 and estimated to be growing at a CAGR of 5.8%, to reach $331.41 billion by 2021" and "The future growth of anti-aging market is observed to rely on the advancement and technological development with enhanced efficacy and safety of anti-aging products"(5).

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan. een 

The plant is very popular for commercial cultivation due to its health benefits. Herbal Aloe Vera has used in traditional medicine to treat wound, burn healing, minor skin infections, sebaceous cysts, diabetes,....... and elevated of cholesterol.

According to the Food Ingredients & Technology Institute, daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin of that may reduce risk of skin wrinkle.

In a 12-week, randomized, double-blind, placebo-controlled study, in 48 apparently healthy men (age range: 30-59 years; average: 45 years), intake of oral Aloe sterol supplementation after 12 weeks showed a significant improvement of the skin elasticity index in comparison in the baseline value.

Dr. Tanaka M, the lead author said, "Aloe sterol ingestion increased skin elasticity in the photodamaged skin of men aged <46 years, and "No Aloe sterol intake-dependent harmful phenomenon was observed during the intake period".

Furthermore, in vitro, Aloe sterols increased production of collagen and hyaluronic acid, natural substance in skin response to connective, epithelial, and neural tissues. approximately two-fold and 1.5-fold, and promoted gene expression levels in human dermal fibroblasts.

In fact, daily oral Aloe sterol-containing Aloe vera gel powder (AVGP) significantly reduced facial wrinkles in women aged ≥40 years as well as stimulated collagen and hyaluronic acid production by human dermal fibroblasts.

In support of the above evaluation, intake of Aloe Vera gel enhanced healthy skin through promoting elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores and skin fatigue area F3,the Food Ingredients and Technology Institute 12 weeks study suggested.

Taking altogether, there is no doubt that oral administration of Aloe Vera or Aloe Vera supplements may improve skin condition including wrinkle, caused by skin aging, but quality of amount intake should only be prescribed by related field specialist. 

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women by Tanaka M1, Misawa E1, Yamauchi K1, Abe F1, Ishizaki C2.(PubMed)
(2) Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial by Tanaka M1, Yamamoto Y, Misawa E, Nabeshima K, Saito M, Yamauchi K, Abe F, Furukawa F.(PubMed)
(3) Aloe sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial by Tanaka M1, Yamamoto Y2, Misawa E1, Nabeshima K1, Saito M1, Yamauchi K1, Abe F1, Furukawa F2.(PubMed)

(4) Free radicals and aging of the skin by Emerit I(PubMed)

(5) Global Anti-Aging Market 2017 is Growing Rapidly and Expected to Reach $331.41 billion by 2021 – Orbis Research
(6) Stacey Colino, a freelance Health & Wellness reporter at U.S. News, in the article of  "6 Surprising Factors That Can Accelerate the Aging of Your Skin"

*Asparagus, the Antidepressant Natural Whole Food, Biomedical Literature Suggested

By Kyle J. Norton, Master of Nutrition

Scientists may have found a dietary vegetable that processes a strong and profound impact in ameliorated psychological depression, recent study suggested.

Depression is a commonly psychological disease that affects your normal feeling, thinking and reacting to events that occur daily in your life.

People with depression may feel ashamed or afraid to ask for help. others suffer in silence.

According to the statistic of the World Health Organization, 300 million people around the world have depression. The numbers of  Americans suffer from depression are increasing at an alarming rate. As of today, 16.2 million adults in the United States or 6.7% of all adults have depression in the country.

Women are more susceptible to develop depression than men and fewer than half of those affected by depression in the world are seeking professional treatment. 

The disease is the leading cause of disability worldwide, and  a major contributor to the overall global burden of diseases.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million

Contrary to some misconceptions, depression can be treated and avoidable.

What cause depression? is debatable, however, genetic predisposition, personality, stress and brain chemistry are found to associate to the onset of the disease.

Chronic medical conditions also can trigger the development of depression. According to the study by the Shanghai University of Sport in the review of 60 articles with a total of 4311 patients, chronic diseases are highly correlated to the expression of depression and reduced quality of life(5).

The study also suggested that increasing SF-36 physical function subscale in such patients in short and long term may have a profound and positive effect in ameliorated depression and improved quality of life.

Use of antidepressants by conventional medicine,  may be effective. However, they can induce side effects of upset stomach, insomnia, sexual problems, anxiety, dizziness,..... and fatigue.

In severe cases, intake of anti depressant may cause serotonin syndrome, seizures, irregular heartbeat and unconsciousness and some people in the group of under the age of 25 may experience suicidal thoughts, according to the BBC report By Lesley Ashmall(6).

Asparagus is a flowering plant, belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and Western Asia.

The vegetable has been used from early times as a food and medicine, because of its delicate flavour and diuretic properties.

In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200 and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST) in mice, researchers found that application of the extract decreases immobility in FST and increases avoidance response in learned helplessness test (LH), an indication of antidepressant activity.

Dr. Singh GK, the lead author said, " MAR had insignificant effect on l-DOPA-induced aggressive behavior indicating absence of activity on dopaminergic system" and  "MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems and augmentation of antioxidant defenses".

Furthermore, the injection of extracts of Asparagus cochinchinensis (AC) also expressed anti depressive effects, through inhibited oxidative stress that cause of neuro cell damage and improve cell signal reponse and signal transmitting.

Total saponin isolated from AC significantly is found ti inhibit free radical of H2O2 in induction of cell death in cultured cortical neurons.

Additional analysis suggested that AC antidepressant-like and neuroprotective (reducing infarct size) effects are associated to the activation of Shp-2 pathways which are associated to inhibition of depression in animal model.

Some researchers suggested that antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system....

Moreover, the study also showed that AR may be used as food and have potential drug-drug, drug-food and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending message between neuro cells, induced protective activities against development of depression.

These results suggested that asparagus ameliorated depression is it's neuroprotective effect by inhibited free radical that cause neuro cells damage and improved cell signal response.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti depression possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
(5) Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials by Wang X1,2, Pi Y3, Chen B1, Chen P1, Liu Y4, Wang R4, Li X1, Zhu Y5, Yang Y6, Niu Z(PubMed)
(6) The 'extreme' side-effects of antidepressants By Lesley Ashmall